Digital Commons Network^™

Immunosuppressive Formulations For Immunological Defense Against Traumatic Brain Injury, Abhirami Thumsi, Abhinav P. Acharya, Jeffrey Capadona, Sanmoy Pathak, Taravat Khodaei, Madan Mohan Chandra Sekhar Jaggarapu, Abhirami P. Suresh

Faculty Scholarship

Traumatic brain injury (TBI) and subsequent neurodegeneration is partially driven by chronic inflammation both locally and systemically. Yet, current clinical intervention strategies do not mitigate inflammation sequelae necessitating the development of innovative approaches to reduce inflammation and minimize deleterious effects of TBI. Herein, a subcutaneous formulation based on polymer of alpha-ketoglutarate (paKG) delivering glycolytic inhibitor PFK15 (PFKFB3 inhibitor, a rate limiting step in glycolysis), alpha-ketoglutarate (to fuel Krebs cycle) and peptide antigen from myelin proteolipid protein (PLP139-151) is utilized as the prophylactic immunosuppressive formulation in a mouse model of TBI. In vitro, the paKG(PFK15+PLP) formulation stimulates proliferation of immunosuppressive regulatory …

Logic Enriched Over A Quantale, Alexander Kurz

Engineering Faculty Articles and Research

Many-valued logics have a long history in mathematical logic as well as in applications to the semantics of programming languages and to engineering more generally. Typically these logics are rich with features motivated by the particular applications they stem from. In his 1973 article "Metric Spaces, Generalized Logic, and Closed Categories", Lawvere argued that any quantale Ω gives rise to a generalized Ω-valued logic that has as its models the categories enriched over the quantale. This suggests developing a uniform framework for many-valued logics parameterized in a quantale. In this talk we will review some previous and ongoing work in …

07.28.2025 Ored Connect, Liz Williamson

ORED Newsletter

On-demand training courses released

• Mentoring
• My Project Was Funded, Now What?

Notice of Funding Opportunity SMART Act Accelerate Initiative

Memo Regarding Contact from Federal Agencies

“Silent Is Not Actually Silent”: An Investigation Of Toxicity On Bug Report Discussion, Mia Mohammad Imran, Jaydeb Sarker

Computer Science Faculty Research & Creative Works

Toxicity in bug report discussions poses significant challenges to the collaborative dynamics of open-source software development. Bug reports are crucial for identifying and resolving defects, yet their inherently problem-focused nature and emotionally charged context make them susceptible to toxic interactions. This study explores toxicity in GitHub bug reports through a qualitative analysis of 203 bug threads, including 81 toxic ones. Our findings reveal that toxicity frequently arises from misaligned perceptions of bug severity and priority, unresolved frustrations with tools, and lapses in professional communication. These toxic interactions not only derail productive discussions but also reduce the likelihood of actionable outcomes, …

Llput: Investigating Large Language Models For Bug Report-Based Input Generation, Alif Al Hasan, Subarna Saha, Mia Mohammad Imran, Tarannum Shaila Zaman

Computer Science Faculty Research & Creative Works

Failure-inducing inputs play a crucial role in diagnosing and analyzing software bugs. Bug reports typically contain these inputs, which developers extract to facilitate debugging. Since bug reports are written in natural language, prior research has leveraged various Natural Language Processing (NLP) techniques for automated input extraction. With the advent of Large Language Models (LLMs), an important research question arises: how effectively can generative LLMs extract failure-inducing inputs from bug reports? In this paper, we propose LLPut, a technique to empirically evaluate the performance of three open-source generative LLMs-LLaMA, Qwen, and Qwen-Coder-in extracting relevant inputs from bug reports. We conduct an …

Selenium Nanoparticles Synthesized By Pulsed Laser Ablation In Liquids For Antimicrobial Applications, Tina Hesabizadeh

Theses and Dissertations

This study aimed to synthesize selenium nanoparticles (Se NPs) by Pulsed Laser Ablation in Liquids (PLAL) and investigate their antibacterial and biological effects, particularly their impact on cell viability and related biological responses. Spherical amorphous Se NPs were produced by irradiating a selenium target using a combination of bottom- and top-ablation protocols. After autoclaving, the amorphous Se NPs were converted into trigonal Se NPs. Se NPs were characterized by using Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Fourier Transform Infrared Spectroscopy (FTIR). The biological effects of Se NPs were quantitatively assessed through evaluations of cell viability and associated …

Bold New Bioweapons: Part 2 — Bold Bolstering Of Deterrence And Defense, James Giordano

Strategic Insights

This commentary, Pt. 2 of the Bold New Bioweapons series, argues that modern biological threats demand a proactive transformation of deterrence and defense strategies. Building on earlier analysis of detection and attribution challenges, Dr. Giordano asserts that emerging life sciences and related technologies, such as synthetic biology, gene editing, and AI-driven bioengineering blur distinctions between legitimate research and weaponizable capabilities. This undermines traditional deterrence frameworks. To address these complexities, the article proposes adaptive, interoperable, and ethical approaches that integrate advanced biosurveillance, precision bioinformatics, AI-enabled threat modeling, and global collaborative governance. It emphasizes the need for robust international norms and resilient …

Flight Instructor Enhanced Qualification Training Program, Brendan Aug

Aviation Student Publications

Due to December 2024 regulatory changes made to 14 CFR Part 61.195(h)— Qualifications to provide ground or flight training to initial flight instructor applicants—a new training program, titled the Flight Instructor Enhanced Qualification Training Program (FIEQTP), must be developed under 61.195(h)(3).

The purpose of this packet is, in response to regulatory changes, to conduct a thorough training needs analysis, and utilizing its conclusions, develop a new 14 CFR Part 141 course and assessment plan that meets the requirements of Part 61.195(h)(3) Flight instructor enhanced qualification training program.

Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma

College of Pharmacy Faculty Papers

Bacteria-mediated cancer therapy represents a novel and promising strategy for targeted drug delivery to solid tumors. Multiple studies have demonstrated that various Bifidobacterium species can selectively colonize the hypoxic microenvironments characteristic of solid tumors. Leveraging this property, Bifidobacterium has been explored as a delivery vector for a range of anti-cancer approaches such as immunotherapy, nanoformulated chemothera- peutics, and gene therapy. Notably, anti-angiogenic genes such as endostatin and tumstatin have been successfully delivered to colorectal tumors using Bifidobacterium infantis and Bifidobacterium longum, respectively. Additionally, Bifidobacterium bifidum has been employed to transport doxorubicin and paclitaxel nanoparticles to breast and lung tumor …

Secure Frameworks For User Motion Data In Virtual Reality, Jayasri Sai Nikitha Guthula

Theses and Dissertations

Virtual Reality is an innovative technology transforming industries such as gaming, healthcare, and remote collaboration. The increasing deployment of these systems results in the continuous collection of telemetry data, including motion patterns, hand gestures, and spatial interactions. This data is valuable for enhancing user experiences and optimizing system performance. However, it also introduces significant privacy risks. Unlike traditional digital footprints, motion data captures fine-grained physical behaviors that can be linked to individual users, making anonymization ineffective in preventing re-identification.This research introduces secure frameworks for user motion data in virtual reality, each proposed framework addressing privacy preservation from a different angle. …

Magnetic Macro Pendulum Design And Real-Time Control Application: Simulation And Experiment, Hüseyi̇n Yildiz, Serdar Yilmaz, Yasemi̇n Poyraz Koçak, Erol Uzal

Turkish Journal of Electrical Engineering and Computer Sciences

Over the last decade, the number of studies in the field of magnetic micro robots has significantly increased due to expectations of performing microsurgery, drug delivery, and similar medical procedures. Magnetic micro robots have advantages over other types of micro robots in terms of having independent designs for rotor and stator structures. Magnetic micro robots can be controlled by magnetic fields and can be programmed to move in certain directions and to perform various functions. This paper implements the computer-aided real-time control of a single-arm micro-pendulum structure to (eventually) perform cell manipulation tasks. The mechanical structure, mathematical model, control circuit …

Intouch Week Of July 28, 2025, New York Medical College

InTouch

• NYMC SOM Student Senate Sets the Tone for the Year Ahead
• Mitchell Cairo, M.D., Engineers Hope to Cure Childhood Cancer
• Menopause Reshapes Skin Health from Hair Loss to Acne
• TCDM Welcomes Class of 2029
• Student Spotlight: Comfort Williams Advances Pulmonary Vascular Research on a Global Stage
• Alumni Spotlight: Maksat Idris, M.D. ’25, Carries the Torch of Medicine Across Generations and Borders

Analysis Of A Saline Dust Storm From The Aralkum Desert – Part 2: Atmospheric Flow Precursors In The Euro-Atlantic Region, Xin Xi

Michigan Tech Publications

Wind-blown dust emissions from the man-made Aralkum Desert pose significant environment and human health risks across Central Asia. Yet, little is known about the atmospheric circulation patterns favoring dust outbreaks from the region. This study examines the role of upstream atmospheric blocking and recurrent transient Rossby wave packets (RWPs) in initiating a severe dust storm from the Aralkum Desert in May 2018. Results show that the dust event was triggered by an unusual early-summer cold air outbreak and attendant postfrontal northerly winds reaching 24–31 m/s. The compound cold air and dust outbreaks were preceded by repeated meridional flow amplification linked …

Enhancing Public Transit By Integrating On-Demand And Fixed Route Transit Services: A Focus On Implementation, Adaption, Equity, And Acceptance, Avani Aravind

Electronic Theses and Dissertations Archive

As cities seek to build inclusive, efficient, and sustainable transportation systems, the integration of on-demand mobility services with traditional fixed-route transit (FRT) offers a promising solution to enhance coverage and connectivity. However, challenges persist in evaluating the cost-effectiveness, accessibility, and user acceptance of such integrated systems. This dissertation presents a comprehensive, three-part framework that addresses these gaps by (1) developing a simulation-based, pre-implementation cost evaluation model, (2) assessing the accessibility and equity outcomes of integrated systems, and (3) exploring the effectiveness of behavioral nudges in influencing transit adoption. The first study introduces an agent-based simulation model to evaluate generalized system …

Dosimetric Effects Of Pinnacle³ Version 18.0 Advanced Auto-Planning Settings In Oropharyngeal Vmat Optimization, Emily Sanden

Masters Projects

This study evaluated the impact of Pinnacle³ version 18.0 auto-planning advanced settings modulation amount, monitor unit (MU) level, and dose fall-off priority on volumetric modulated arc therapy (VMAT) plan quality for bilateral oropharyngeal cancer. A total of 64 plans were generated using all possible combinations of low, medium, high, and very high settings for each parameter. A standardized base of tongue case was optimized once per plan using a single-time point approach, with planned target volume 1 (PTV1) (6996 cGy) and planned target volume 2 (PTV2) (5412 cGy) coverage evaluated. Each parotid gland, the spinal cord, brainstem, and the oral …

Effect Of Parental Support On Learning Engagement In Mathematics Online Learning Environment: The Mediating Role Of Online Self-Regulated Learning Strategies, Malathi Letchumanan, Sharifah Kartini Said Husain, Ahmad Fauzi Mohd Ayub

Higher Learning Research Communications

This study examines the effects of parental support on learning engagement and the mediating roles of self-regulated learning (SRL) in mathematics online learning environments. A sample of 112 undergraduate students from the mathematics departments of two public universities in Malaysia participated in the study. We analyzed the data using descriptive analysis and partial least squares structural equation modeling (PLS-SEM), and the study findings indicate that parental support significantly predicts online self-regulated learning (OSRL). In addition, OSRL is a significant predictor of students’ engagement. The results also suggest that OSRL fully mediates the relationship between parental support and learning engagement. However, …

The Nature Of Anthropogenically Driven River Drying: Spatiotemporal Causes And Consequences, Eliza Inez Gilbert

Biology ETDs

Streambed drying naturally occurs in over 60% of rivers and streams worldwide. Climate change and human regulation of surface and groundwater have increased drying in naturally intermittent systems and caused perennial systems to transition to intermittency, impacting water security, water quality, and biodiversity. To understand human-induced drying dynamics, we used 12 years of daily drying data along a 154-km regulated reach of the Rio Grande. We conceptualized river drying as a regime analogous to the natural flow regime paradigm and quantified drying magnitude, rate of change, and duration. Although linear models predicting drying magnitude and rate of change were uninterpretable, …

Ionic Liquid Enhanced Proton Transfer For Neutral Oxygen Evolution Reaction, Ming-Xing Chen, Nian Liu, Zi-He Dua, Jing Qi, Rui Cao

Journal of Electrochemistry

The development of highly active catalyst in pH-neutral media for oxygen evolution reaction (OER) is critical in the field of renewable energy storage and conversion. Nevertheless, the slow kinetics of proton-coupled electron transfer (PCET) hinders the overall OER efficiency. Herein, we report an ionic liquid (IL) modified CoSn(OH)₆ nanocubes (denoted as CoSn(OH)₆-IL), which could be prepared through a facile strategy. The modified IL would not change the structural characteristics of CoSn(OH)₆, but could effectively regulate the local proton activity near the active sites. The CoSn(OH)₆-IL exhibited higher intrinsic OER performances than the pristine …

Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Bacteria-mediated cancer therapy represents a novel and promising strategy for targeted drug delivery to solid tumors. Multiple studies have demonstrated that various Bifidobacterium species can selectively colonize the hypoxic microenvironments characteristic of solid tumors. Leveraging this property, Bifidobacterium has been explored as a delivery vector for a range of anti-cancer approaches such as immunotherapy, nanoformulated chemotherapeutics, and gene therapy. Notably, anti-angiogenic genes such as endostatin and tumstatin have been successfully delivered to colorectal tumors using Bifidobacterium infantis and Bifidobacterium longum, respectively. Additionally, Bifidobacterium bifidum has been employed to transport doxorubicin and paclitaxel nanoparticles to breast and lung tumor sites. …

Characterization Of The Role Of Rsd-6, A Tudor Domain Protein, In Antiviral Rnai Pathway In Caenorhabditis Elegans, Krishna Prasad Dahal

LSU Doctoral Dissertations

RNA interference (RNAi) triggered by virus produced dsRNA intermediate offers robust innate immunity against invading viruses in plants, insects and animals. Caenorhabditis elegans has been extensively used as a model organism to study host virus interaction. Recently, a forward genetic screen identified RNAi spreading deficient-6 (RSD-6), a Tudor domain protein, as a key component in antiviral RNAi pathway against Orsay virus in C. elegans but its contribution in the pathway remained unclear. Here, we generated a rsd-6 null allele using CRISPR-Cas9 genome editing, crossed it with other known RNAi mutants and analyzed Orsay virus replication in them and in combination …

Cultural Worldview And Rural Consumer Preferences For Genetically Modified Foods, Nathan P. Kemper

Agricultural Economics and Agribusiness Faculty Publications and Presentations

The consumer acceptance of genetically modified (GM) foods varies widely based on personal values and social context. This study investigates how cultural worldviews—measured through the Individualism–Communitarianism and Hierarchical–Egalitarianism dimensions—affect willingness to pay (WTP) for food labeling attributes related to GM content. We surveyed 932 U.S. primary grocery shoppers and conducted a discrete choice experiment (DCE) with poultry product options. Using a Mixed Logit model and supplemental cognitive data from Query Theory, we find that rural individualists are more accepting of GM-labeled products. At the same time, urban communitarians show a stronger preference for non-GM labels. These results offer insight into …

Ai-Based Object Detection And Risk Identification For Enhanced Construction Site Safety, Mahdi Bonyaniakbarabadi

LSU Master's Theses

Recent advancements in computer vision for construction site safety have encountered significant hurdles, especially in the nuanced tasks of object detection and the identification of unsafe worker behaviors. These challenges are often exacerbated by complex and cluttered backgrounds, wide variations in object scale, and inconsistent image quality. While existing methodologies have utilized attention mechanisms to analyze spatial and temporal features, they frequently neglect the benefits of adaptive sampling and channel-wise feature adjustments, thereby failing to exploit potential spatiotemporal redundancies. This thesis introduces a two-pronged approach to address these limitations. First, we propose the Optimized-Position Network (OP-Net), a novel architecture for …

The Impact Of Non-Athletic, Flat-Soled Sneakers On Gait Kinematics: A Comparative Analysis With Socks, Aaron Aguilar, Kharen Bautista, Juan Claros, Raquel Dimaano, Ciara Franke, Mason Huber, Evan Kurishige, Anton Lam, Kevin Le, Alohi Sheung, Raj Kumar Chauhan, Sivakumar Rajagopal, Seong Hyun Moon, Michael Shiraishi, Rahul Soangra

Physical Therapy Faculty Articles and Research

This study investigates the kinematic effects of non-athletic, flat-soled sneakers on lower extremity joints during walking. Ten healthy gym-goers (24.4 ± 1.7 years) underwent treadmill gait analysis under two conditions: wearing non-athletic sneakers and walking with only socks. Gait was captured using the Gait Real-time Analysis and Interactive Lab (GRAIL). Dependent variables included cadence, support times, and stride length. Walking with socks significantly increased cadence (p <  .0001) and single support time (p = .0103), and decreased initial (p = .018), terminal (p = .0056), and total double support times (p = .0092). No significant difference in stride length was observed. These …

Comparative Designs Reveal Preferences For Human-Generated Rather Than Ai-Generated Art, Oliver Jacobs, Farid Pazhoohi, Grayson Mullen, Alan Kingstone

School of Psychology

The evaluation of AI-generated art has seen increased interest after widespread access to AI-generated art (e.g., DALL-E or Stable Diffusion). While previous studies have suggested that there are preferences for human-generated art, the research remains far from robust with numerous contradictory findings. One potential reason for this discrepancy is differing experimental designs employing comparative or non-comparative methods. To shed light on this problem, two experiments were conducted: one using a Likert scale (N = 250) and another using a 2-alternative forced choice design (N = 102). Our conflicting results between the two designs suggest that traditional Likert-based art appraisals in …

Cyber Attacks On Government-Managed Systems: A Social Epistemology Perspective, Aurelia Bunga Anggun Putri Romavella, Fristian Hadinata

International Review of Humanities Studies

This article examines cyberattacks on government-managed systems from the perspective of social epistemology. The development of information technology, particularly the internet, has changed the way governments operate and interact with the public. However, these changes have also created new vulnerabilities to cyberattacks that can disrupt public services, undermine public trust and threaten national security. Social epistemology, with its focus on how knowledge and beliefs are constructed and disseminated in society, provides a useful analytical framework for understanding these cyberattack dynamics. This article examines how cyberattacks affect the production, distribution and validation of knowledge in the context of governance. By analyzing …

The Establishment Of Jakarta International Schoolin Indonesia As A Reflection Of Globalisation Through Education, Brandon Cahyadhuha Rusdy, Linda Sunarti

International Review of Humanities Studies

"This article examines the establishment of Jakarta International School (JIS) within the context of the globalisation of Indonesia. Established in 1951 under the name International School of Djakarta by Antoinette Stepanek, an educator from the United States, it was the first school to provide an English-language education for the children of expatriates in Jakarta, Indonesia. The school underwent several name changes throughout its history. In 1965, the school was renamed to Joint Embassy School to reflect the support from a coalition of embassies, consisting of the United States, United Kingdom, Australia and Yugoslavia. In 1978, the school was renamed again …

The Middle Class, The Youth, The Highways: Production Of Space And Urban Memory In Blok M, Jakarta, Bimana Novantara, Yudi Bachrioktora, Lilawati Kurnia

International Review of Humanities Studies

This paper examines the historical and contemporary dynamics of the Blok M area in Jakarta as a public space undergoing a process of spatial, cultural, and symbolic transformation. Using Henri Lefebvre’s theory of the production of space and then relating it to the discourse of urban memory according to Abidin Kusno, this study traces how Blok M developed from the modernist urban planning of Kebayoran Baru after independence to be the epicenter of youth festivity, then declined until it rose again through a place that utilized the memory of this area in the past. This study highlights how the politics …

Regulating The Amount Of Graphene Oxide For Enhanced Capacitive Energy Storage Of Mof Derived Materials, Yong-Ji Qin, Jing-Quan Yang, Hao Wang, Mei-Ling Lian, Pei-Pei Jia, Jun Luo, Xi-Jun Liu, Jun-Feng Liu

Journal of Electrochemistry

In pursuit of more efficient and stable electrochemical energy storage materials, composite materials consisting of metal oxides and graphene oxide have garnered significant attention due to their unique structures and exceptional properties. Graphene oxide (GO), a two-dimensional material with an extremely high specific surface area and excellent conductivity, offers new possibilities for enhancing the electrochemical performance of metal oxides. In this work, we synthesized metal- organic framework (MOF) and GO composites by regulating the amount of GO, and successfully prepared composites of metal oxides supported by nitrogen-doped carbon frameworks and GO through a simple one-step calcination process. Based on the …

Use Of A Shoulder-Mounted Wearable Sensor Prototype Designed To Detect Opioid-Related Overdose: A Qualitative User Experience Study, Alexis M. Roth, Ally K. D'Angelo, David Gordon, Benjamin Cocchiaro, Anush Lingamoorthy, Rose Laurano, Matthew Salzman, Jacob S. Brenner, Cameron Baston

SKMC Student Presentations and Publications

BACKGROUND: For over a decade, drug overdose has been the leading cause of injury and accidental death in the United States. Most fatal overdoses involve opioids and occur during solitary drug use events when no one is available to initiate lifesaving responses (eg, naloxone). While there is a growing interest in devices providing early overdose detection and automated responses, little research has engaged end users in a device design process.

OBJECTIVE: This study aimed to describe user experience, perceived harms and benefits, and the acceptability of a shoulder-mounted wearable sensor among people who inject drugs who wore a device prototype …

2025 Deerfield Fair 4-H Building Project Premium Book, Extension

UNH Cooperative Extension

No abstract provided.