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Potential Of Legume Seeds From The Leguminosae Family As Material Source Of Food And Medicine : A Literature Review, Ni Made Ayu Gangga Dewi, Nina Dewi Oktaviyanti, Aurapa Sakulpanich, Kartini Kartini

Pharmaceutical Sciences and Research

Leguminosae, also known as Fabaceae, is the third largest plant family after Orchidaceae and Asteraceae. This review aimed to explore the potential of several legume species indigenous to Indonesia, from the Leguminosae family, as sources of food and medicine. The data used for the analysis were collected from various online databases such as PubMed, ScienceDirect, and Google Scholar. The results showed that there were 13 species of Leguminosae family plants found easily in Indonesia including Cajanus cajan, Canavalia ensiformis, Mucuna pruriens, Arachis hypogaea, Vigna subterranea, Glycine max, Phaseolus vulgaris, Phaseolus lunatus, Vigna radiata, Vigna unguiculata subsp. unguiculata, Vigna angularis, Vigna …

Indian Cosmology And Archaeoastronomy Of The Khmer Stone Temples In Sakon Nakhon-Thailand, Duangden Boonpok

International Review of Humanities Studies

This article is multidisciplinary study of cosmology, archaeology and astronomy of the Khmer stone temples in Sakon Nakhon. The study investigates of the temple’s architectural structure and environmental geography which related to the astronomical knowledge. The result of study found that the plan and structure of temples is influenced by the concept of Indian cosmology which has Mount Meru as the central axis. Buildings is signified as mountain or heaven with high and multi-layered base. The main building is symbolically important as the origin of power for the whole temple. The objects and positions are the transforming of cosmology concept …

Investigating The Determinants Of Influenza Entry And Spread In Human Airway Cells Using Fluorescence Microscopy, Zijian Guo

McKelvey School of Engineering Graduate Student Theses & Dissertations

Influenza A virus (IAV) remains a significant global health challenge. IAV utilizes the receptor binding protein hemagglutinin (HA) and the receptor destroying protein neuraminidase (NA) to facilitate infection. The activities of these proteins affect multiple steps in IAV life cycle. However, it remains unclear how these IAV factors influence infection dynamics in the context of a complex cellular environment encountered in the respiratory tract. In this work, we use fluorescence microscopy and human airway epithelial cells to study influenza biology at the single-cell and single-virion level, revealing key insights into viral binding, entry, and spread. First, we focused on the …

Network Intelligence For Next-Generation Wireless Networks: Advancing Distribution And Coordination, Yonatan Melese Worku

Electrical and Computer Engineering ETDs

Next-generation wireless networks, encompassing 6G and beyond, face rigorous demands for ultra-low latency, ubiquitous connectivity, exceptionally high data rates, and robust security, necessitating innovative approaches to resource optimization and network protection. This dissertation proposes a pioneering framework that synergizes advanced methodologies—deep reinforcement learning, deep learning, blockchain, and multi-agent systems—to address these challenges. Distributed architectures, underpinned by AI-driven multi-agent systems, form the backbone of this framework, enabling seamless integration and intelligent orchestration across diverse domains. The research advances IoT-based systems leveraging machine learning for resource efficiency in healthcare applications, develops reinforcement learning-driven frameworks to optimize energy and coverage for Unmanned Aerial …

Finite Element Investigation Of Blast Load Responses In Nuclear Power Plant Containment Structures, Janak Raj Awasthi

Civil Engineering ETDs

Some significant incidents like the Chernobyl disaster (1986), the Fukushima Daiichi hydrogen explosion (2011), and some frequent military and terror threats to the nuclear Power plant structures have led to studying the capacity of power plant structures to withstand blast loadings. From this research, even one-third of the loss of the coolant is enough to damage the power plant structure. Crack starts from the wall and propagates toward the top of the dome and the foundation. The external blast shows high damage symptoms near the foundation area. Most of the steel members, including the rebars, Liner, and Tendons, showed high …

Predicting Leakage From Nuclear Material Containers At Los Alamos National Laboratory Through Drop Testing, Leak Testing, Finite Element Analysis And Digital Image Correlation, Jude M. Oka, Yu-Lin Shen, Osman Anderoglu, Pankaj Kumar, Rajendra Vaidya

Mechanical Engineering ETDs

Los Alamos National Laboratory (LANL) relies on containment vessels to safely manage special nuclear material. These containers are subject to rigorous testing—such as drop, fire, and water ingress testing—to ensure integrity under adverse conditions. While elastomer-based seals are well studied, metal-to-metal sealing mechanisms remain under investigation, particularly under dynamic loading. This research focuses on the relationship between container mating surfaces and impact loading through drop testing. Finite Element Analysis (FEA) models were developed and validated using Digital Image Correlation (DIC) to measure strain during impact. Drop tests at varying heights showed strong correlation between FEA and DIC results, confirming the …

Networked Systems: Synchronization, Decomposition And Transient Dynamics, Amirhossein Nazerian

Mechanical Engineering ETDs

This dissertation investigates synchronization, transient dynamics, control, and signal amplification in networked dynamical systems. First, it examines complete and cluster synchronization, including cases with large parametric mismatches, in both natural (e.g., brain networks, fireflies) and technological systems (e.g., power grids, robotics). Second, it studies transient dynamics in consensus processes, designing synchronization strategies that link reactivity, contraction theory, and Lyapunov exponents. Third, it addresses the computational limits of Model Predictive Control (MPC) for large networks by introducing an algebraic decomposition method that enables parallel online computation of smaller subproblems, enhancing MPC performance under hardware constraints. Finally, it analyzes the structural role …

Instability Analysis In Cylindrical Thin Film–Compliant Core Structures: Numerical Simulations And Effects Of Inelastic Deformation, Md Al Rifat Anan

Mechanical Engineering ETDs

When a thin film bonded to a thick compliant substrate is subject to in-plane compression, wrinkles can develop if the critical state for instability is reached. In various applications the film/substrate system may also take the form of cylindrical fibers, where an axial compressive loading can trigger axisymmetric wrinkles. A straightforward computational approach to simulate such wrinkling behavior is needed for material design, to either prevent wrinkling or to exploit its benefits for flexible device applications. In this work a comprehensive numerical study is undertaken by employing the finite element method. The embedded imperfection approach used previously for planar structures …

Multiscale And Multi-Model Studies Of Metal Plasticity, Luo Li

Mechanical Engineering ETDs

Plastic deformation is the process in which the material deforms permanently due to external effects. Twinning and slip are two main mechanisms of plastic deformation in metallic materials. The prominent mechanism of plastic deformation in metals that have FCC crystal structures is slip or gliding movement of dislocations, which is mainly focused on here. In the current study, frameworks for investigating plasticity phenomena of metals at different scales ranging from microscale to macroscale are demonstrated. Specifically, the macroscale modeling of plastic response of metallic materials induced by indentations are emulated by nonlinear FEA simulations. Simulation results of macroscale modeling are …

Phase Nanoscopy With Correlated Frequency Combs, Xiaobing Zhu

Optical Science and Engineering ETDs

In this dissertation a sensing method applying to any physical quantity that modifies optical phase is developed. Two pulses are produced inside a synchronously pumped Optical Parametric Oscillator, generating two identical, undistinguishable frequency combs. The physical quantity to be measured applies a small phase shift/round trip to one of the pulses, resulting in a frequency shift of the corresponding comb. The latter frequency is measured as a beat by interfering the two combs on a detector. A world record resolution, close to the quantum limit, of 0.033 nanoradian (corresponding to 0.006 fm in displacement) is achieved. A detailed analysis of …

Advancing Diamond Quantum Sensors: Isotropic Flux Concentrators And Phase Noise Mitigation, Maziar Saleh Ziabari

Optical Science and Engineering ETDs

Two methods for improving the sensitivity of nitrogen vacancy quantum sensors in diamond are explored. First, by passively concentrating the magnetic flux, three orthogonally oriented ferrite truncated cone pairs amplify the field isotropically by 19 times, allowing measurement of Earth's field without a bias field and increasing sensitivity. Through thorough analysis, modeling and tuning a novel 3-dimensional flux concentrator system, we achieve a fractional standard deviation of less than 1% anisotropy and quantify minimal deadzones and ambient temperature-limited variations below 40 nT/hour. Second, we characterize, model and calculate phase noise in NV experiments, which in NV sensors is effectively indistinguishable …

A Systematic Approach To The Characterization Of Liquid-Vapor Coexistence In Platinum, Meghan K. Lentz

Physics & Astronomy ETDs

Platinum is a material standard used in high pressure and shock compression experiments at Sandia National Laboratories. During experiments, materials are subjected to a very large range of thermodynamic conditions, during which materials regularly enter the liquid-vapor coexistence region. Despite its status as a standard, the region around the liquid-vapor critical point is poorly understood for platinum, with reported critical temperatures spanning approximately 7000 K. In this dissertation we conduct density functional theory based molecular dynamics (DFTMD) simulations for platinum for a range of temperatures and densities near liquid-vapor coexistence. The phase diagram for platinum is refined near the critical …

Understanding The Metallic And Oxide Phases In Platinum-Based Bimetallic Heterogeneous Catalysts After High-Temperature Oxidation, Stephen John Porter Jr

Nanoscience and Microsystems ETDs

Platinum (Pt) and palladium (Pd) are critical components in diesel emission control systems, enabling the conversion of harmful pollutants under demanding conditions. However, Pt’s effectiveness is hindered by sintering under high-temperature oxidizing environments. This dissertation investigates how Pt and Pd evolve under oxidizing conditions at 800°C, highlighting their distinct thermodynamic behaviors and interactions. Using TEM, EDS, EELS, XRF, XRD, and EXAFS, we show that Pd suppresses Pt sintering by reducing the volatility of PtO₂, leading to the formation of stable particles. Both Pt and Pd are present in metallic and oxide states, forming biphasic 'Janus' particles with conjoined metal and …

A Mutational Analysis Of Thatisin: How Single Point Mutations Impact The Biosynthetic Process Of A Group 16 Graspetide, John F. Boynton Jr

Chemistry and Chemical Biology ETDs

Abstract:

Graspetides are a family of Ribosomally synthesized and Post-translationally modified Peptide (RiPP) natural products named for their ATP Grasp Macrocyclases. We identified several Graspetide Biosynthetic Gene Clusters containing common double glycine cleavage motifs and attempted characterization of the mature Graspetides. One of the resulting peptides, Thatisin, has a topology with two interlocking macrolactones installed by a single ATP Grasp Ligase named ThtC. Here we use single and double point mutations to observe the impact or variation on the installation of these macrocycles. Alanine scan mutagenesis is used to assess leader peptide residues in the precursor peptide ThtA to determine …

Improving Infiltration Model Performance In Arid And Urban Regions, Samuel Stephen Coulter

Civil Engineering ETDs

Flooding in arid regions is infrequent but damaging and limited historical data makes flood modeling an important tool for flood infrastructure design. This study improves flood modeling guidance by using plot-scale tests to determine the impact of slope, compaction, gravel mulch and landscape fabric on infiltration and runoff rates in sandy soil types. This data will be used as guidance for the linear and constant model. The performance of this model was compared with the curve number model for a hypothetical 100-year design storm. Results showed that gravel mulch increased infiltration rates by 66% and reduced erosion on steep and …

Health Impacts, Air Pollution And Electric Vehicles In California, Pufan Qi

Economics ETDs

This research examines the impact of electric vehicles (EVs) on air quality in California over the period from 2010 to 2021, as well as the implications of air pollution for respiratory health, organized into five chapters. The initial chapter provides background information and outlines the objectives, findings, and contributions. The second chapter examines the relationship between air quality and electric vehicles by utilizing fixed effect panel regression models. The third chapter employs panel regressions with Poisson control models to assess the correlation between changes in air quality resulting from electric vehicles and the prevalence of respiratory diseases. The fourth chapter …

College Football Or Abortion Education? An Examination Of The University Of Arizona’S 1974 Stadium Bonds Bill, Emma Masterson

History ETDs

In 1974 the University of Arizona renovated their football stadium through a bonds bill passed by the state legislature. The renovations allowed the university to increase the stadium’s capacity by 17,000 seats. While in the state house, an Arizona Congressman attached a rider to the bonds bill banning the university’s medical school from performing abortions in most circumstances, effectively barring the university from teaching the medical students how to perform the procedure as well. This thesis seeks to position the University of Arizona football stadium renovations and abortion ban within the larger histories of American higher education and Arizona. This …

Exploration, Expansion, And Optimization Of Bacteriophage Virus-Like Particle Vaccines, Andzoa N. Jamus

Biomedical Sciences ETDs

Bacteriophage virus-like particles are highly immunogenic, self-assembling platforms used for various vaccines. This work shows efforts to explore new vaccine candidates against Chlamydia trachomatis, targeting proteins that play critical roles in attachment and entry into the host cell, as well as in pathogenesis and bacteria proliferation. This work also shows the optimization of previously identified candidates, by investigating how altering routes of immunization can change the antibody profiles elicited, both systemically and locally. Finally, this work shows the establishment of various Chlamydia infection models in an effort to expand the ways in which vaccine efficacy can be investigated, particularly …

Advancements In Microarray Manufacturing Enable Emerging Technologies, Kendall Hoff

Biomedical Engineering ETDs

Significant advances in manufacturing technologies have enabled the production of new DNA microarrays for use in emergent technology. Photolithography, wafer scale manufacturing, and improvements in synthesis chemistry and design enable high-throughput production of extremely high-quality arrays. These new arrays offer extremely high oligonucleotide densities, in the range of tens of thousands of oligonucleotides per square micron. They also offer smaller features sizes, with millions of features per square centimeter. Furthermore, they can be manufactured with the DNA tethered at either end to the surface, leaving either the 5’ or 3’ end free and available for use in enzymatic reactions; and …

Toward Simulating 2d Cell Surfaces In A Disk, Myriam Allred

Mathematics & Statistics ETDs

Certain evolution models of cell surfaces (treated in two-dimensions) involve the solution of the Helmholtz equation with jump conditions enforced on an immersed closed curve. This thesis presents a sparse, modal spectral method for solving such Helmholtz problems. The solution is required to be continuous across the curve, but with a jump discontinuity in the normal derivative proportional to the planar curvature. The method relies on classical Fourier-Chebyshev basis functions, with the application of modal Chebyshev integration matrices to achieve sparse, banded approximations of the Helmholtz equation. The method achieves spectral convergence, despite the inherent low regularity of the relevant …

Derivation Of Adjoint Based Error Estimates For Nonlinear Ordinary Differential Equations With Application To Multistage Sir Models With Demographics, Daniel Alcala

Mathematics & Statistics ETDs

Ordinary Differential Equations (ODEs) are central to the mathematical modeling of various real-world phenomena, from mechanical systems governed by Newton’s laws to epidemic dynamics described by SIR-type ODEs. Since many ODEs do not admit closed-form analytic solutions, we approximate them numerically (e.g., with Euler’s, Runge–Kutta, or other such methods). This raises the key question: How accurate are these numerical solutions? In particular, reliably estimating the error in some quantity of interest (QoI) at time T without having an exact solution is of great scientific interest.

The first main contribution of this thesis is the development and analysis of adjoint-based error …

Transforming Cancer Care: A Narrative Review On Leveraging Artificial Intelligence To Advance Immunotherapy In Underserved Communities, Victor M. Vasquez Jr., Molly Mccabe, Jack C. Mckee, Sharon Siby, Usman Hussain, Farah Faizuddin, Aadil Sheikh, Subramanian Dhandayuthapani, Shrikanth Gadad, Jessica Chacon

School of Medicine Publications

Purpose: Cancer immunotherapy has transformed oncology, but underserved populations face persistent disparities in access and outcomes. This review explores how artificial intelligence (AI) can help mitigate these barriers. Methods: We conducted a narrative review based on peer-reviewed literature selected for relevance to artificial intelligence, cancer immunotherapy, and healthcare challenges, without restrictions on publication date. We searched three major electronic databases: PubMed, IEEE Xplore, and arXiv, covering both biomedical and computational literature. The search included publications from January 2015 through April 2024 to capture contemporary developments in AI and cancer immunotherapy. Results: AI tools such as machine learning, …

Staff Education To Increase The Number Of Continuous Glucose Monitors (Cgms) Prescribed At An Adult Primary Care Clinic For Individuals With Type 2 Diabetes., Josephine Opara

Walden Dissertations and Doctoral Studies

This quality improvement project focused on increasing the use of continuous glucose monitors (CGMs) in primary care for patients with type 2 diabetes. Its goal was to enhance providers' ability to prescribe and manage CGMs effectively. A review of existing literature and a provider survey identified key barriers, such as limited time and insufficient provider education on CGMs. The survey emphasized educational needs related to initiating and prescribing CGMs. Educational materials, including a PowerPoint presentation on prescribing, monitoring, and management, were developed and shared with clinic staff. Consequently, CGM prescriptions increased over the three-month period. The project aimed to improve …

Understanding Black American Pastors' Leadership Role And Interaction With Public Health During Covid-19, Stacy L. Tolbert

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic tested the leadership, response, and resilience of Black American pastors and their communities. These pastors played a crucial role in supporting their communities to lessen the impact the virus had on underlying health conditions and socioeconomic hardships that were exacerbated by the pandemic. Despite their efforts, Black American pastors frequently encountered challenges helping their community. The current research sought to understand the lived experiences of Black American pastors during the pandemic and their interactions with public health institutions to secure resources for their communities through Interpretative Phenomenological Analysis (IPA). The study was guided by the research question, …

Effective Strategies That Marketing Leaders Use To Increase Fan Base, Denise Leslie Rosa

Walden Dissertations and Doctoral Studies

Despite its growth and potential, the Women’s National Basketball Association (WNBA) consistently struggles to generate profit, remaining unprofitable in its 28th (2024) season and heading into its 29th (2025) season. The inability of women’s professional basketball marketing leaders to generate increased revenue and fan engagement has limited the sport’s growth and visibility. Grounded in McCarthy’s four Ps of marketing concept that includes product, price, place, and promotion, the purpose of the qualitative pragmatic inquiry project was to identify and explore effective and innovative marketing strategies that marketing leaders use to increase the revenue of women’s professional basketball teams and their …

Experiences Of Women In K–12 Educational Technology Leadership Positions, Natalie M. Johnson

Walden Dissertations and Doctoral Studies

The problem addressed in this study was the lack of women in K–12 educational technology leadership positions in the United States. The purpose of this basic qualitative study was to explore the experiences of women in K–12 educational technology leadership regarding the challenges and successes they encountered in achieving and maintaining their positions. Feminist standpoint theory formed the framework for this study. Semistructured interviews were conducted with 10 women who were active or former K–12 educational technology leaders in public schools across the country. Open and pattern coding were used to support thematic analysis. An overarching theme of gender bias …

Guardian Perceptions Of Living In Group Homes Versus Family Homes For Individuals With Intellectual Disabilties, Gail Roberts Williams

Walden Dissertations and Doctoral Studies

The living environment of group homes and family homes offer different qualities of life for individuals with intellectual disabilities. Guardian perceptions may shed light on how individuals with intellectual disabilities perceive their experiences, environments, and daily lives. Exploring and examining this social problem may positively impact policies, processes, and procedures, and have an impact on the lives of parents, families, and individuals with intellectual disabilities while driving positive social change. The purpose of this qualitative study using narrative inquiry was to explore, examine, and better understand guardian perceptions. The quality-of-life theoretical framework and Saldana’s process of color coding were used …

Effects Of Neoadjuvant Immunotherapy On Hearing In Patients With Head And Neck Squamous Cell Carcinoma, Bryce Hambach, Anhelina Bilokon, John Lee, L. Noelle Allemang, Jennifer Chisholm, Chris K. Zalewski, Julie Christensen, Carmen C. Brewer, James L. Gulley, Clint T. Allen, Lisa L. Cunningham, Katharine A. Fernandez

SKMC Student Presentations and Publications

Immune checkpoint blockade (ICB) is a commonly used treatment modality for cancer with a growing list of oncologic indications. Ototoxicity is a potential immune-related adverse event of ICB treatment, but the risk of hearing loss after ICB remains unknown. This retrospective chart review sought to identify individuals who received ICB and had available audiometric data before and after treatment in order to identify clinically meaningful changes in hearing. This single center, institutional chart review examined hearing function data in patients who underwent audiometry before and after ICB treatment. Measures included pure tone thresholds, distortion product otoacoustic emissions (DPOAEs), tympanometry, and …

Optimization And Acceleration Of Puf Design Through Reduced Order Standard Cell Modeling, Ian Z. Wilcox

Electrical and Computer Engineering ETDs

Application Specific Integrated Circuit (ASIC) designs continue to scale with ever increasing complexity and device counts in the billions. Demand for scalable high-fidelity simulations of these systems drives the need for the development of novel modeling capabilities. This research formulates a non-intrusive model order reduc-tion (MOR) framework, called PUF-ROMS, to accelerate and optimize the design and analysis of physical unclonable functions (PUFs) on ASICs. The primary goals of PUF-ROMS are to estimate entropy and temperature-voltage noise (TV-noise) of circuit structures used in the design in an accelerated evaluation environment to enable designers to explore architecture options with the goal of …

Xpert Mtb/Rif Ultra Assay For Pulmonary Tuberculosis And Rifampicin Resistance In Adults And Adolescents, Elizabeth Chandler Church, Jonah S Kreniske, Alexander W Kay, Katie Scandrett, Karen R Steingart, Yemisi Takwoingi

Faculty, Staff and Students Publications

Background: Xpert MTB/RIF Ultra (Xpert Ultra) is a molecular World Health Organization (WHO)-recommended rapid diagnostic test that simultaneously detects tuberculosis and rifampicin resistance. This review updates a comparative accuracy Cochrane review of Xpert MTB/RIF and Xpert Ultra as Xpert Ultra has replaced Xpert MTB/RIF.

Objectives: To determine the diagnostic accuracy of Xpert MTB/RIF Ultra (Xpert Ultra) for detecting pulmonary tuberculosis and rifampicin resistance in adults and adolescents with presumptive tuberculosis based on signs or symptoms or with an abnormal chest x-ray suggestive of tuberculosis.

Search methods: We searched seven databases including CENTRAL, MEDLINE, and Embase, plus two trial registers (ClinicalTrials.gov …