Digital Commons Network^™

Precision Medicine And Beyond: Evolving Roles Of Targeted Therapy, Immunotherapy, And Artificial Intelligence In Oncology, Linwei Li, Anika Doppalapudi, Jennifer Escamilla, Annu Karithara, Christine Pham, Angel Phillip, Sriya Gullapalli, Lois Baldado, Arjun Bellamkonda, Daniela Gonzalez, Amin Ibrahim, David Sta. Maria, Kaitlyn Ybanez, Hugo Zamarron, Shizue Mito

School of Medicine Publications

Precision medicine in oncology is an evolving therapeutic approach that leverages genetic, clinical, and biomarker data to tailor treatments to individual patients. This review explores the three core pillars of modern precision oncology: targeted therapy, immunotherapy, and the integration of artificial intelligence (AI) into clinical practice. Targeted therapies, including monoclonal antibodies and antibody-drug conjugates, selectively inhibit molecular pathways involved in tumor growth. While conventional chemotherapy remains the backbone of treatment and has improved remission rates, its cytotoxic nature limits broader applicability and increases the risk of comorbidities. Immunotherapies, particularly immune checkpoint inhibitors and chimeric antigen receptor T-cell therapies, have transformed …

University Of Dayton Adds Seven Trustees, Welcomes New Board Chair, University Of Dayton

News Releases

The University of Dayton added seven highly accomplished members to its 2025-26 board of trustees, including significant contributors to its record-breaking "We Soar" campaign, senior business executives, a young legal standout and two Marianists with decades of service in the Society of Mary.

Penggunaan Preposisi Tetap Bahasa Belanda Oleh Mahasiswa Program Studi Belanda Semester 3 Dan 5 Tahun Ajar 2024/2025, Caesi Rosprianti, Eliza Gustinelly

Multikultura

This study examines the use of fixed prepositions in Dutch by third- and fifth-semester students of the Dutch Studies Program in the academic year 2024/2025. The topic of this research is related to linguistics, specifically grammar and vocabulary. The theoretical framework used in this study is the meaning of fixed prepositions by Van den Toorn, Willy Vandeweghe, and Walter Haeseryn. et al. This research employs a descriptive method with a quantitative approach to analyze the extent of third- and fifth-semester students' ability in answering questions related to the use of fixed prepositions, classified according to their association with verbs, adjectives, …

Effects Of Long-Term Exposure On Composite Manufactured Marine Propellor Blades In Pure Distilled Water And Artificial Seawater, Jacob Brady

The Plymouth Student Scientist

The aim of this research was to establish the feasibility and investigate the mechanical challenges of the use of composite materials for a marine propellor. Focusing on the major challenge of hygroscopic swelling and the effect this has on material dimensions and properties. Flax-epoxy and carbon-epoxy samples were manufactured and tested in distilled water and artificial seawater to establish the effects of hygroscopic ageing over long-term exposure. Accelerated ageing at 60°C was used to minimise experimental duration whilst observing long-term effects. The research also identified proposed values for the co-efficient of hygroscopic expansion in three planes of 2x2 twill weave …

Women Empowerment Through Food Production Project In A Peri-Urban Landscape, Riyanto Adji

ASEAN Journal of Community Engagement

The paper discusses a community project related to local food production by a group of women in an idle peri-urban landscape. Instead of positioning women solely as homemakers within the house, this project views them as active participants of a peri- urban community. On the other hand, the availability of idle land in the peri-urban context can be utilized, allowing it to be transformed into an active space for growing food. Responding to the idea, a community project was conducted with a group of women farmers in a housing complex situated near the Bubulak Village, Bogor, Indonesia. They utilized an …

From Affordance To Passive Flow: Unveiling The Mechanisms Behind Young Adults' Unplanned Use Of Short Video Platforms, Shishi Wu

Graduate Doctoral Dissertations

Unplanned usage of short video platforms has become a widespread behavioral pattern, especially among young users who often spend more time on these platforms than they intend to. This phenomenon cannot be fully explained by addiction or self-control failure. This study introduces the construct of Passive Flow, a non-volitional immersion state shaped by platform design. Passive Flow includes three experiential features: users engage without clear goals, gradually lose self-awareness, and experience time distortion. These states are not initiated by deliberate choice but are triggered by algorithmic and interface-level features. To examine this mechanism, the study adopts a two-phase design. The …

Utilization Of Biomass From Kerai Payung Trees And Waste Paper Through Pyrolysis Technology To Support The Zero-Waste Concept, Anggita Putri Indadari, Nurfa Anisa, Asih Budi Santoso

Journal of Mechanical Engineering Science and Technology (JMEST)

Wisnuwardhana University is a private institution with a green campus environment surrounded by Kerai Payung trees. This environment produces organic waste from trees and inorganic waste such as used paper from campus activities. This study aims to achieve zero-waste processing by using pyrolysis technology to process campus waste, ensuring minimal residue. The experimental method involves comparing waste processing outcomes between conventional combustion and pyrolysis, the data was analyzed by comparing the results of pyrolysis with conventional combustion. The results of biochar from the pyrolysis process of used paper, Kerai Payung leaves, and nagging Kerai Payung tree are 76 g, 250 …

Exploring Open Pedagogy Principles: A Qualitative Study Of Undergraduate Experiences, Staci Gilpin, Stephanie Rollag Yoon, Virginia Clinton-Lisell

Education, Health & Behavior Studies Faculty Publications

Open pedagogy, characterisedby students creating or co-creating artefacts that others may use, offers transformative opportunities for students to move beyond passive learning into active content creation. This qualitative study examines the experiences of 25 undergraduate students who engage with open pedagogy principles, including creation-centred learning, collaboration, audience engagement, and the integration of Open Educational Resources (OER) and Creative Commons (CC) licensing. Using surveys and interviews, we identified three key themes: the importance of real audiences, authentic connections over prescribed collaborations, and rethinking the role of Creative Commons. Findings suggest that open pedagogy enhances student engagement and provides meaningful, real-world applications …

2020-10-06 Leadership Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2021-01-26 Leadership Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

2021-05-11 Leadership Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

Predicted Inelastic Response Of Conventional And Ductile Steel Concentrically Braced Frame Buildings Under Wind Loads, Conrad Hamblin Belshe

Theses and Dissertations

The inelastic response of three-story steel concentrically braced frame buildings under wind loads was simulated to determine the applicability of ductile braced frame design to wind load applications. This study examined three types of steel concentrically braced frames: a conventional braced frame, a ductile braced frame, and a ductile braced frame with a reduced beam requirement. Braced frames were designed for four design wind speeds (220 mph, 156 mph, 127 mph, and 110 mph), for a total of nine unique braced frame designs. Nonlinear static pushover analysis was used to determine system overstrength and ductility under wind loads. Eigenvalue vibration …

Ctnna3 Deficiency Promotes Heart Regeneration By Enhancing Cardiomyocyte Proliferation In Neonatal Mice, Sha Zou, Wuhou Dai, Wufan Tao, Jifen Li, Zeyi Cheng, Hongyan Wang

Department of Medicine Faculty Papers

Background: Heart regeneration requires renewal of lost cardiomyocytes. However, the mammalian heart loses its proliferative capacity soon after birth, and the molecular signaling underlying the loss of cardiac proliferation postnatally is not fully understood.

Purpose: This study aimed to investigate the role of Catenin alpha 3 (Ctnna3), coding for alpha T catenin (αT-catenin) protein in regulating cardiomyocyte proliferation and heart regeneration during the neonatal period.

Methods: Here we report that ablation of Ctnna3 and highly expressed in hearts, accelerated heart regeneration following heart apex resection in neonatal mice.

Results: Our results show that Ctnna3 deficiency enhances cardiomyocyte proliferation …

Data-Driven Approach To Dynamic Resting State Functional Connectivity In Post-Traumatic Stress Disorder: An Enigma-Pgc Ptsd Study, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven …

The Processes That Contribute To Readiness To Learn For An Accelerated Nursing Graduate: A Grounded Theory Study, Kaye A.L. Whyte

Theses & Dissertations

The worldwide nursing shortage has led to maintaining an adequate nursing workforce as a global challenge. Increased recruitment efforts have fostered changes to some educational programs, giving rise to the proliferation of Accelerated Nursing Programs (ACCEL). These accelerated nursing programs are a highly successful way of educating future registered nurses, leading to concerns by registered nurses, hospital administrators, and nursing faculty who question the transitional competence of graduates from Accelerated Nursing Programs. The purpose of this study was to understand the transition processes for accelerated nursing graduates. The intended impact of this research was important to nursing for two reasons: …

Protective Multi-Stressor Interactions In The Anthropocene: Key Considerations For Investigating Cross-Tolerance In A Conservation Context, Essie M Rodgers, Simone Baldanzi, Michael Collins, W Wesley Dowd, Lauric Feugere, Giovanna Mottola, Fanny Vermandele, Daniel F Gomez Isaza

School of Biological and Marine Sciences

In the Anthropocene, species are increasingly faced with multiple stressors that are more severe and less predictable than before. While multiple stressors often interact to affect organisms negatively, sometimes these interactions can be beneficial, enhancing resilience through cross-protection. Cross-protection interactions occur when exposure to one stressor, such as elevated temperature, enhances an organism’s tolerance to a different stressor, like hypoxia, through shared protective mechanisms or signaling pathways. Understanding the potential for cross-protection to combat rapid and diverse environmental change is crucial for conservation, as it potentially alters the predicted consequences of such change. Here, we outline 10 key considerations for …

Foreword From Editor - 17th Edition: Empowering Stakeholders: Reinventing Dialogues And Collaborations, Yandi Andri Yatmo, Kristanti Dewi Paramita, Rini Suryantini

ASEAN Journal of Community Engagement

This edition of AJCE examines the various frameworks and dialogues between stakeholders within their community engagement programs that aim to activate the structures and systems of society. This issue comprises three research articles that highlight the importance of community involvement in supporting programs with diverse objectives, including nature protection, rural development, and learning aid initiatives. In addition, this issue features three case-based articles that aim to discuss how community programs generate different ways of responding to societal issues, creating space for reflection and collaboration. The contributors to this study came from diverse backgrounds and fields of study, including forestry, architecture, …

Live-In Tajuk: Role-Play Model In The Co-Creation Of Community-Based Design Practices, Resza Riskiyanto, Nurul Syala Abdul Latip, Maheswara Rizky Pasopati, Brandi Orbita Imagi Putri Agung

ASEAN Journal of Community Engagement

This article examines a collaborative project that involves diverse actors in the co-creation of community-based design within an agricultural context. This study focuses on the implementation of the role-playing model as a practice that cultivates empathy, reflexivity, and collective agency among actors. The model is implemented through several methods, including collective reading of the context, dynamic role shifting, and the negotiation of architectural program. As part of community service, this seven-day program involved four groups, each consisting of four local students and two international students, four lecturers and design practitioners, and four household units, to participate in the role-playing and …

Revisiting The Post-Tsunami Aceh School: A Community-Based Evaluation Framework For Improving Build Back Better Projects, Muhammad Naufal Fadhil, Aji Sofiana Putri, Muhammad Fadli Muslimin

ASEAN Journal of Community Engagement

This study proposes a community-based evaluation framework to assess and improve the existing conditions of post-tsunami schools based on the occupants’ evaluations. Rapid, donor-driven reconstruction often defaults to ‘fit-for-all’ solutions that bypass community needs, resulting in facilities that are misaligned with local contexts. This project focused on Lampageu State Elementary School in Banda Aceh, Indonesia, which was reconstructed in 2009 by a German NGO after the 2004 tsunami. The project began by observing the school’s physical condition through the community engagement team, followed by a review and exploration of the school’s design needs with the school community. The community-based evaluation …

From Concept To Community: Phased Modularity In A Participatory Public Space Design, Bramasta Putra Redyantanu, Aris Budhiyanto, Agus Dwi Hariyanto

ASEAN Journal of Community Engagement

This paper examines the idea of modularity as an extensive framework within the participatory design approach. Modularity is explored not only as a design and construction method but also as a collaboration framework that allows architecture to evolve through collaboration. In exploring the idea, this paper elaborates modularity through a community service design project at Alun-Alun Cemara Miagan, an open space in Miagan Mojoagung, Indonesia, emphasizing a participatory approach that involved local stakeholders and architects in developing a multifunctional public space. Due to the phased funding from the government, the project adopted modular strategies to enable flexible, incremental development aligned …

Learning From Conditional Data Distributions, Jizhou Huang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Traditional machine learning paradigms often rely on a single global model trained on an entire dataset, aiming for broad generalization across all instances. However, in many real-world applications, the underlying data distribution is heterogeneous, and meaningful predictions often require models that focus on specific subpopulations rather than treating the data as a whole. This motivates the study of learning from conditional distributions, a framework where predictive models are designed to capture the structure and properties of restricted subsets of the data, leading to improved accuracy, fairness, and interpretability. This dissertation explores three key subproblems that exemplify different aspects of learning …

Beyond Memorization: Developing Three-Dimensional Assessments For Earth Science Through The Carbon Cycle Unit, Stephanie Kay

Masters Projects

This Master's project addresses the critical need for improved assessment strategies in science education, particularly within the context of the Next Generation Science Standards (NGSS). Traditional summative assessments, often relying on multiple-choice or fill-in-the-blank questions, frequently fail to evaluate students' higher-level thinking and comprehensive understanding as required by the NGSS's three-dimensional learning framework (science and engineering practices, crosscutting concepts, and disciplinary core ideas). This disconnect can hinder accurate student knowledge evaluation and limit the development of essential 21st-century skills like critical thinking, problem-solving, and collaboration. The project aims to enhance effective assessment by developing a high school Earth Science unit …

Investigation Into Intraocular Pressure Distribution Via Computer Aided Engineering (Cae), Madison Maureen Hinman

Masters Theses

The leading cause for irreversible blindness and vision loss is glaucoma - an eye condition associated with elevated intraocular pressure (IOP). Increased IOP is also seen during other pathological conditions like spaceflight-associated neuro-ocular syndrome (SANS), and non-pathological conditions as when playing a wind instrument. The study aimed to describe the influence of different vitreous cavity size as well as vitreous fluid viscosity on the IOP as measured at the back of the eye on the retina. Improved understanding of eye pressure transmission can aid in a better understanding of eye diseases. The experiment conducted included cavities of varying size and …

New Kid On The Block: An Evaluation Of Web-Scale Discovery Services, Anita Winger, Blair Booker

Publications

Web-scale discovery systems emerged in 2007 as a new product in library search and retrieval. Libraries have different platforms to choose from and do so based on how well they integrate with the existing Integrated Library System. Each platform offers features, such as relevancy ranking systems, citation trails, and link resolvers, to enhance the search experience and manage electronic resources effectively.

The Constellation Of American Voters: Understanding Americans Who Live In And Out Of American Municipalities, Jordan Duffin Wong

Arts & Sciences Graduate Student Theses and Dissertations

More than 130 million Americans live in unincorporated areas, or the spaces outside the boundaries of cities, towns, and villages. Despite this, relatively little attention has been paid to whether, how, and why residents of unincorporated areas differ from their municipality-dwelling counterparts. In this dissertation, I explore the answers to these questions by establishing a new theoretical framework that rigorously defines, bounds, and partitions unincorporated space. Drawing on the near-universe of American voters, I illustrate, with unparalleled precision, where and how Americans have sorted into and out of municipalities, and show that different mechanisms drive these phenomena. Furthermore, I explore …

Effect Of Various Canopy Shapes On The Drag Coefficient Of Pickup Trucks, Khairil Anwar, Muhammad Syaiful Fadly, Muhammad Wahyu Hermanto

Journal of Mechanical Engineering Science and Technology (JMEST)

The aerodynamic performance of light commercial vehicles, such as the Suzuki Carry, plays a crucial role in their fuel economy and road stability. One typical add-on, a canopy, often changes that airflow and, as a result, alters the drag acting on the vehicle. In this study, three different canopy shapes, flat, curved, and triangular, were examined to understand how each one affects the drag coefficient (Cd). To investigate this, both wind tunnel trials and CFD runs were conducted to track the airflow and measure any changes in drag with greater detail. For reference, the exact vehicle without a canopy was …

Influence Of Different Nanoparticles On Thermophysical Properties And Wear Resistance Of Corn Oil-Based Cutting Fluid In Mql-Cnc Milling Machining, M Nuril Anwar Habiby, Poppy Puspitasari, Aminnudin Aminnudin, Diki Dwi Pramono, Ahmad Atif Fikri, Mariyam Jameelah Ghazali

Journal of Mechanical Engineering Science and Technology (JMEST)

Vegetable oil-based cutting fluids have emerged as a promising innovation in machining operations, supporting the advancement of sustainable and eco-friendly manufacturing practices. This study delves into the development of a biolubricant derived from corn oil, enriched with 0.15% mass fractions of various nanoparticles, including calcium carbonate (CaCO3), copper oxide (CuO), and multi-walled carbon nanotubes (MWCNT). These nano-cutting fluids were applied through the Minimum Quantity Lubrication (MQL) method during CNC milling of AISI 1045 steel. The investigation focused on evaluating thermophysical properties, including density, thermal conductivity, and dynamic viscosity, as well as tool wear performance. The results demonstrated that CuO nanoparticles …

Steam Supply Evaluation For Carbon Capture And Storage In A Subcritical Coal-Fired Power Plant, Veri Hendrayawan, Anggit Raksajati, Sanggono Adisasmito, Firman Bagja Juangsa

Journal of Mechanical Engineering Science and Technology (JMEST)

The aim of this study is to analyze the implementation of carbon capture and storage (CCS) in coal-fired power plants (CFPP) in Indonesia by determining the reboiler energy demand through steam source analysis. The study uses a representative 3×330 MW subcritical coal-fired power plant (CFPP), with an emission intensity of 1.02 tCO₂/MWh and flue gas CO₂ concentration of 13.8%. CCS modeling shows the reboiler requires about 2.9×10⁹ kJ/h energy, supplied by steam extracted from the plant’s steam cycle. A steam cycle model was developed to evaluate the impact of steam extraction. Potential tapping points analyzed include main steam, cold reheat, …

Advancing Interactive Web Cartography Through Designing And Developing An Open-Source, Data-Driven Framework For Accessible Geovisualization Of Geospatial (Big) Data, Sarigai Sarigai

Geography ETDs

The growth of geospatial big data has intensified the demand for open-source, accessible tools for interactive spatial exploration. This dissertation introduces a modular web mapping framework and details its design, extension, and evaluation to advance geovisualization through user-centered, transferable design. The first study presents the original framework, named dciWebMapper, establishing foundational cartographic and information visualization principles, with a focus on modularity and extensibility. The second study extends dciWebMapper with advanced capabilities—such as diverse map types, bivariate visualizations, temporal filtering, spatial querying, and hotspot analysis—and demonstrates its broad transferability across domains. The third study offers a structured usability evaluation of …

Cultivating The Wild: Strategies For Entrepreneurs Navigating Niche And Specialty Food Markets, Trey Malone, Courtney F. Cooper

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Introduction Consumer demand for authenticity and sustainability in food systems is growing, creating both opportunities and challenges for entrepreneurs in niche and specialty markets. While wild-foraged and hunted foods are often perceived as more "natural" and sustainable, attempts to scale these products through farming may compromise their perceived authenticity.Methods To explore these dynamics, we conducted discrete choice experiments with a nationally representative sample of 1,039 U.S. consumers. Participants evaluated their willingness to pay (WTP) for salmon, venison, and morel mushrooms, presented in both wild-foraged/hunted and farm-raised forms.Results Consumers exhibited strong preferences for wild versions of all three products, with average …