Digital Commons Network^™

The Influence Of Ultra-Wide Field Fluorescein Angiography On The Diagnosis And Management Of Diabetic Retinopathy, Joelle A Hallak, Rawan Allozi, Aziz A Khanifar, Thanos D Papakostas, Christina Y Weng, Ronald C Gentile, J Peter Campbell, Jessica G Lee, Gennady Landa, Felix Y Chau, William F Mieler, Meenakashi Gupta, Amani A Fawzi, Judy E Kim, Jennifer I Lim, Robison Vernon Paul Chan

Faculty, Staff and Students Publications

Purpose: To study the influence of ultra-widefield fluorescein angiography (FA) on the diagnosis and management of diabetic retinopathy (DR).

Methods: Ten experts in DR completed an online survey in which they were asked to diagnose and manage DR cases using different imaging modalities. Experts independently reviewed 20 cases of DR and provided a diagnosis and management plan for each case, first based on ultra-widefield color-free and red-free images alone and again with the corresponding ultra-widefield FA images. Experts were polled on their diagnostic confidence, use of FA in clinical practice, and opinions on the value of ultra-widefield FA. Based on …

Dissemination And Implementation Of A Telehealth-Enabled Program For Providing Infectious Disease Expertise In Rural Settings, Robin L P Jump, Jason P Burnham, Et Al.

2020-Current year OA Pubs

BACKGROUND: Telehealth can facilitate improving antibiotic use and related antimicrobial stewardship activities in facilities underserved by infectious diseases (IDs) expertise. We describe implementation of the Department of Veterans Affairs (VA) videoconference antimicrobial stewardship team (VAST) to connect multidisciplinary teams from rural VA medical centers (VAMCs) with geographically distant ID experts.

METHODS: We implemented VASTs at 10 rural VAMCs from September 2021 to February 2024. VASTs consisted of regular meetings between rural VAMCs and an off-site ID expert who met by videoconference to discuss clinical cases, emphasizing recommendations for antibiotic prescribing. The VA Corporate Data Warehouse was used to collect information …

The Microrna Mir-30a Blocks Adipose Tissue Fibrosis Accumulation In Obesity, Pradip K Saha, Robert Sharp, Aaron R. Cox, Rabie Habib, Michael J. Bolt, Jessica B. Felix, Claudia E. Ramirez Bustamante, Xin Li, Sung Yun Jung, Kang Ho Kim, Kai Sun, Huaizhu Wu, Samuel Klein, Sean M. Hartig

2020-Current year OA Pubs

White adipose tissue (WAT) fibrosis occurring in obesity contributes to the inflammatory and metabolic comorbidities of insulin resistance and type 2 diabetes, yet the mechanisms involved remain poorly understood. Here, we report a role for the broadly conserved miRNA miR-30a as a regulator of WAT fibrosis and systemic glucose metabolism. Mice modified to express miR-30a at elevated levels in adipose tissues maintain insulin sensitivity coupled with reduced fatty liver disease when fed a high-fat diet. These effects were attributable to cell-autonomous functions of miR-30a that potently increase expression of adipocyte-specific genes. Proteomic screening revealed miR-30a limits profibrotic programs in subcutaneous …

Quantum Dot Light Emitting Diodes As A Light Source For Photodynamic Therapy, Hamid El Hamidi

Graduate Doctoral Dissertations

ABSTRACT:

QUANTUM DOT LIGHT EMITTING DIODES AS A LIGHT SOURCE FOR PHOTODYNAMIC THERAPY

Photodynamic therapy is a cancer treatment modality that involves the accumulation of a photosensitizer, exposure to visible light, and the presence of oxygen, resulting in the formation of highly reactive and cytotoxic singlet oxygen. PDT has been shown to be more effective as the fluence rate decreases due to oxygen availability and the absence of photobleaching. On the other hand, Quantum Dot Light Emitting Diodes QLEDs- a new form of light source based on nanoparticles (quantum dots)- emerge as a potentially advantageous light source for certain types …

Organizational Health Literacy In Pediatric Cardiovascular Programs, Eva Gomez

Graduate Doctoral Dissertations

Health literacy refers to a person’s ability to access, understand and use health-related information in order to effectively manage one's health and navigate healthcare experiences. This responsibility does not rest solely upon the individual; healthcare organizations also have a vital role in assisting individuals in accessing, understanding and using health information through their interactions with the healthcare system. Organizational health literacy (OHL) can serve as a strategy to ensure that all individuals have equitable access to health information and services. The Ten Attributes of a Health Literate Healthcare Organization established the foundational principles of organizational health literacy. The present study …

The Evolution Of The High Redshift Quiescent Population In Cosmos-Web, Carter B. Flayhart

Theses

Understanding the quiescent galaxy population is incredibly important in the context of galaxy evolution. These galaxies are defined as having a low star formation rate, and their evolved stellar populations makes them identifiable by their redder colors in both the observed and rest-frame. Since their rest-frame optical emission lies in the infrared (IR) regime, observations of these galaxies at high redshifts were quite difficult prior to the launch of the James Webb Space Telescope (JWST). Recent observations of this high redshift population conflict with galaxy formation and evolution models that existed prior, with quiescent galaxies being detected more frequently than …

Gender-Diverse Individuals' Mathematics Self-Efficacy, Aliya Halterman

All Graduate Theses and Dissertations, Fall 2023 to Present

Many factors influence how well someone learns and achieve in school and daily living, with motivation being especially important. One key part of motivation is something called self-efficacy, which refers to how much someone believes they can successfully do a specific task (Bandura, 1986; 1997). Research has shown that self-efficacy plays a major role in how well people do, and the quality of their efforts (Pintrich & Schrauben, 1992; Weinstein & Mayer, 1986; Zimmermann, 2000). Additionally, mathematics skills are tied to better outcomes in school, careers, and in daily life. Mathematics also has also had a complex history when it …

Graph-Based Machine Learning: Higher-Order Interactions, Guided Generation, And Knowledge-Graph Tools, Thomas J. Kerby

All Graduate Theses and Dissertations, Fall 2023 to Present

This dissertation brings the power of graph thinking to three key challenges in modern AI, making complex data more transparent, generative design more controllable, and scholarly exploration more intuitive. First, we introduce Local CorEx, a new machine learning technique that uncovers hidden relationships among variables, making it easier to understand complex datasets without heavy computation. Next, we show how to guide the creation of new molecules by viewing the generation process itself as a walk through a "state graph," letting researchers steer outcomes toward desired chemical properties—without any extra model training. Finally, we deliver an open-source toolkit that builds interactive …

Risk Perceptions And Water Governance: Experiences Of Irrigation Companies In The Great Salt Lake Basin Of Northern Utah, United States, Bailey M. Holdaway

All Graduate Theses and Dissertations, Fall 2023 to Present

Irrigation companies are important water management entities in the Western US. However, these companies often face barriers when managing water. Particularly as the state of Utah grows and water resources are drying, there is much finger pointing at those in irrigation and agriculture for better water management. However, pointing fingers without the participation of these companies often does not lead to effective water management outcomes. Therefore, it is important to understand the role of these irrigation companies, and particularly how they are approaching water management.

I set out to understand the role of these irrigation companies, specifically in the Great …

Examining The Development Of Collective Classroom Efficacy At The Secondary Level, Bradley K. Dutson

All Graduate Theses and Dissertations, Fall 2023 to Present

How can educators develop cohesive and productive learning communities at the secondary level? Prior research has investigated how classrooms develop collective classroom efficacy (CCE) or the shared belief that, as a classroom, they can achieve their learning goals together as a community. Previous studies suggest that CCE at the elementary level is developed with a teacher acting in the role of a community organizer. The teacher employs social and academic practices which incorporate the use of relevance, relationship, and responsibility. These help to establish four key elements of developing CCE which include: 1) a positive classroom environment, (2) persistence and …

Linearized Rigid-Body Dynamics Of Asymmetric Aircraft, Troy A. Abraham

All Graduate Theses and Dissertations, Fall 2023 to Present

Most aircraft are symmetric about their mid-plane, which permits simplifying assumptions when modeling their aerodynamic and mass properties, as well as estimating their dynamic modes. This work considers methods for modeling asymmetric aircraft, including capturing the dynamic mode characteristics that result from their asymmetric properties. While the primary focus of this work is on the dynamic mode properties of these aircraft, a significant portion of the dissertation is dedicated to modeling their aerodynamic, mass, and trimmed flight characteristics. The linearized rigid-body aircraft equations of motion used for dynamic mode estimates are developed to include the effects of asymmetries in both …

Exploring Methods For Quantifying Uncertainty In Neural Network-Based Turbulence Closures, Cody Grogan

All Graduate Theses and Dissertations, Fall 2023 to Present

Machine Learning (ML) is a very promising field for data-driven modeling of different phenomena. In the field of Computational Fluid Dynamics (CFD), ML is an enticing alternative to traditional methods to improve the accuracy and computational efficiency of simulations. However, many ML models, like Neural Networks, don’t quantify their uncertainty or indicate their confidence in a prediction to those who wish to use them. This is especially important because the use of inaccurate ML predictions in a CFD simulation can greatly impact the validity of a simulation. However, with uncertainty quantification, an ML model can indicate to a modeler the …

Evaluating The Impact Of Maximum Aero-Thermal Heating On A High-Speed Fixed-Wing Atmospheric Aircraft Optimum Trajectory, Benjamin M. Ford

All Graduate Theses and Dissertations, Fall 2023 to Present

This study explores how extreme heating affects the flight paths of hypersonic aircraft—vehicles that travel at speeds many times faster than sound. Analyzing how to fly a high-speed aircraft without overheating it can prevent structural failure while operating at maximum possible performance. The results shown in this section indicate that it is possible to operate at very high speeds in an aircraft while keeping peak vehicle temperature below our limits while saving fuel.

Optimization Of The Root Zone In Controlled Environment Agriculture, Brendan Fatzinger

All Graduate Theses and Dissertations, Fall 2023 to Present

Controlled environment agriculture (CEA) helps grow plants in spaces where resources like water and nutrients are limited, such as deserts or spacecraft. Effective management of water in the root zone, the area where plant roots grow, is vital to keeping plants healthy, especially in closed-loop systems where water cannot be wasted, as will be necessary for long-duration space missions.

An improved automated watering system designed for use in space-like environments was developed over several trials. Early designs using suction to draw water through tubes faced problems with uneven watering and roots blocking the tubes. Switching to a system that pushed …

Evaluating Cyanotoxins In Surface Water And Aerosols Near Utah Lake, Dylan R. Mcpeake

All Graduate Theses and Dissertations, Fall 2023 to Present

Utah Lake is a freshwater lake in Utah County near Provo, Utah. It is the third- largest lake in Utah and is important for recreation and local businesses. However, from June to October, the lake often has cyanobacteria harmful algal blooms (cHABs), which contain a toxin called cyanotoxin. These toxins can be dangerous to people who come into contact with the water. Government agencies regularly check for cHABs and warn people when the water is unsafe for activities like swimming. Collecting water samples to test for cHABs can be risky because it can possibly result in direct contact with the …

An Optimization Study Of Multi-Orifice Synthetic Jets, Rhett T. Parry

All Graduate Theses and Dissertations, Fall 2023 to Present

From the mixing of creamer into coffee, to the dynamics of a dust storm, or smoke rising from a chimney—everything is driven by turbulent fluid motion. Experimentalists bring the complex driving mechanism that is turbulence into a laboratory setting to fundamentally understand its behavior in response to certain test parameters. Researchers may choose various drivers, or “actuators”, of fluid motion to start the turbulent regime for their applications. However, in building an entire experimental apparatus, they miss the step of ensuring that an individual driver is performing as best as possible. A common actuator used in experimental studies is a …

Optimal Distributed Energy Resource Control And Scheduling In A Microgrid Framework, Timothy M. Dodge

All Graduate Theses and Dissertations, Fall 2023 to Present

As we use more renewable energy, such as solar power, and add new devices, such as electric vehicle chargers and battery storage, to our buildings, the management of electricity becomes more complex. These local energy sources and devices can form small "microgrids" that need careful coordination to work efficiently with the main power grid. The system figures out the best times to use, store or charge different devices (such as batteries and EVs) to avoid costly, high electricity demand spikes and help stabilize the main power grid, especially when asked by the utility company. A major part of this work …

Analysis Of Thrust Performance And Noise Generation Of Uam Composite Propellers Fabricated Using Composite-Based Additive Manufacturing, Samiul Alam

All Graduate Theses and Dissertations, Fall 2023 to Present

Urban air mobility (UAM) is an emerging transportation concept that uses lightweight, efficient aircraft for transporting goods and passengers and performing other logistical activities. One of the biggest challenges in developing UAM from a structural perspective is manufacturing strong and reliable propellers that are lightweight and durable. Traditional manufacturing methods for composite propellers are expensive, time-consuming, and difficult to scale. This study explores a new approach using Composite-Based Additive Manufacturing (CBAM) to produce high-performance propellers more efficiently. CBAM allows for the fabrication of strong, lightweight composite propellers using short manufacturing lead times. However, one challenge with this technique is that …

"Why Does Coach Do That?" Exploring Influences Of Coach Behavior In Non-Elite Women's Artistic Gymnastics, Katherine Vernay Adams

All Graduate Theses and Dissertations, Fall 2023 to Present

This two study dissertation explores coaching in women's artistic gymnastics, as the sport has been criticized for harsh and controlling coaching methods. The first study investigated whether coaches who experienced mistreatment as young gymnasts were more likely to adopt controlling coaching practices. While there was no direct link, those with a history of mistreatment tended to struggle more with managing their emotions. The second study tested whether coaches view controlling coaching as more acceptable for younger or more advanced gymnasts. The results showed that neither age nor skill level made a difference—controlling coaching was generally viewed as unacceptable, while supportive …

Metaheuristic Planning For Vehicle Fleets With Kinematic, Uncertain, And Battery Constraints, James Swedeen

All Graduate Theses and Dissertations, Fall 2023 to Present

The planning of vehicle actions and movements is becoming increasingly important in daily life. With the growing list of potential and current applications of autonomous planning, the field is faced with an ever-growing list of complications. These complications make the task of producing efficient plans increasingly difficult. This research studies and develops solutions for a few of the most important vehicle planning applications in recent years.

First, there is the planning of vehicle motion while considering the physical limitations of the vehicle. For many vehicles, for example, cars, airplanes, and boats, the biggest limitation is the inability to pan directly …

An Ant-Colony Approach To Scheduling Charging Sessions Of Electric Vehicle Fleets With Heterogeneous Scheduling Constraints, Derek D. Redmond

All Graduate Theses and Dissertations, Fall 2023 to Present

Electric vehicles and electric-vehicle fleets are gaining widespread usage. A major challenge of managing an electric-vehicle fleet is scheduling when the vehicles can charge and when the vehicles can complete their tasks. Finding smart ways to schedule electric-vehicle charging reduces both the cost of charging vehicles and increases the health of the grid and the environment. This best-of-both-worlds outcome is because of the pricing structure that electric utility companies use. When minimizing the cost of charging the vehicles, it is important to consider that vehicle fleets have constraints on when they can charge. Vehicles are usually limited by the tasks …

Precision Agriculture Applications In Tart Cherries: Yield Mapping Technologies And Remote Sensing For Water Stress Estimation, Anderson Luiz Dos Santos Safre

All Graduate Theses and Dissertations, Fall 2023 to Present

Tart cherry is an important specialty crop in the United States, particularly in Utah where the area dedicated to tart cherry cultivation is larger than any other fruit grown in the state. However, growers face increasing challenges due to rising land prices, limited water availability, and extreme weather events. These factors make it essential to adopt new technologies that improve efficiency and sustainability. Precision agriculture, which uses data-driven tools to manage crops more effectively, can help address these challenges. However, most tart cherry orchards still rely on traditional practices due to a lack of specialized technologies for this crop. This …

From Supercomputers To Desktops: An Interactive And Portable System For Particle In Cell Simulation And Visualization Using Commodity Hardware, Kim Peterson

All Graduate Theses and Dissertations, Fall 2023 to Present

Generating and analyzing visual representations of simulation data in real time (i.e., during execution), has become increasingly important for handling the complexity and scale of modern computational models. Traditionally, this approach has been limited to High-Performance Computing (HPC) environments, leaving some researchers, students and educators without resources to explore cutting-edge simulations and analyses. This work attempts to show that powerful scientific simulations and real-time analysis can be made available by using more easily obtained commodity hardware. This approach may enable a broader participation in the scientific computing discovery process.

In this paper, we explore how advanced simulation and visualization frameworks …

Exploring Biotic And Abiotic Drivers Of Ecosystem Properties: The Influence Of Waterbirds And Photodegradation On Wetland Ecosystems, Lindsay Miller

All Graduate Theses and Dissertations, Fall 2023 to Present

Wetlands provide a wide range of valuable ecosystem services: these are benefits from the environment that support human well-being, such as water filtration, fish and bird habitat, and shoreline protection. Despite their importance, wetlands are among the most threatened ecosystems, facing increasing pressure from natural and human activities. To better predict the future of wetlands and guide effective management and restoration practices, we need to understand the various forces shaping their ecological properties. In this thesis, we examined the influence of two forces: waterbirds and photodegradation (the process by which sunlight breaks down plant material). To explore each of these …

A Focus On Student Education: Determining Student Attitudes Towards Transparent Autograding And Developing Artificially Intelligent Tools To Help Students Succeed, Andra Rice

All Graduate Theses and Dissertations, Fall 2023 to Present

This thesis is composed of two parts both relating to helping students succeed. First, the focus is on determining how we can help students feel more comfortable using an AI tool that can provide them immediate feedback. Second, machine learning algorithms are explored in relation to tracking student tasks to encourage healthy study habits.

The development of effective autograders is key for scaling assessment and feedback. While AI based autograding systems for open-ended response questions have been found to be beneficial for providing immediate feedback, autograders are not always liked, understood, or trusted by students. Our research tested the effect …

Temperature Effects On Fruit Doubling And Bloom Prediction In Tart Cherry, Josette M. Moon

All Graduate Theses and Dissertations, Fall 2023 to Present

Tart cherry (Prunus cerasus) is a key horticultural crop in Utah. Extreme summer heat and cold weather in late spring are challenges to tart cherry production causing economic losses. These problematic weather conditions are influenced by the local landscape and are exacerbated by changing climate. This research explores (1) the impact of summer heat stress on fruit deformities, and (2) the accuracy of temperature-based predictions of spring bud development. High temperatures and water stress after harvest are known to cause a deformity known as twin or double fruits, resulting in unmarketable fruit. This disorder has been studied in …

Population Analysis Of Cyanobacteria In Rotating Algal Biofilm Reactors, Eric H. Matthews

All Graduate Theses and Dissertations, Fall 2023 to Present

Algal biofilms have numerous applications in wastewater treatment and bioproduct production. The Sustainable Waste-to-Bioproducts Engineering Center at Utah State University is working to develop rotating algal biofilm reactors (RABRs) to remove excess nitrogen and phosphorus from wastewater effluent while producing biomass for downstream production.

Genetic analysis of algal biofilms on various RABRs was performed to gain improved understanding of the biofilm populations. This analysis focuses on a pilot-scale RABR and how it compares to several other RABRs. Additionally, old methods of genetic analysis filtered out important cyanobacterial populations. A new method was developed to identify the cyanobacteria within the biofilms. …

Assessing Public Satisfaction And Transportation Choices During Winter Road Maintenance: A Case Study Of Utah, Shailendra Khanal

All Graduate Theses and Dissertations, Fall 2023 to Present

Winter road maintenance is essential to keeping people safe and mobile during snowstorms. In Utah, where winter weather is a regular part of life, the Utah Department of Transportation (UDOT) plays a vital role in keeping roads clear and functional. While much attention is given to how roads are plowed and managed, there has been less focus on how the public experiences these efforts—and how the decisions to travel during storms are shaped by personal circumstances and perceptions.

This research sets out to understand two things: how satisfied people are with winter road maintenance, and what influences their transportation decisions …

A Computational Study On Impact Performance Of Concrete Barriers For Protecting Transportation Assets, Ashesh Pokhrel

All Graduate Theses and Dissertations, Fall 2023 to Present

Highway safety is a major concern as roads accommodate increasing numbers of vehicles, including large trucks and tractor-trailers. Concrete barriers are commonly used along highways and bridges to prevent accidents by redirecting vehicles and protecting important structures like bridge piers. However, their effectiveness depends on how well they withstand vehicle impacts, how they perform after being damaged in previous crashes, and how they protect bridge piers when space is limited. This research examines these issues using advanced computer simulations to better understand barrier performance and improve roadway safety.

The first part of this study reviews how researchers and engineers use …

Too Many Mergers? The Golden Parachute As A Driver Of M&A Activity In The 21st Century, Jeffrey N. Gordon

Faculty Scholarship

This Article argues that the corporate governance regime in the United States has produced a level of mergers and acquisition activity greater than the social optimum because of the current version of the “golden parachute,” a super-bonus payoff to a target CEO. In the late nineteenth through the twentieth century, M&A activity was characterized by “waves” that reflected adaptations to changing external environment, whether the efficient production frontier, regulatory constraints, or capital market developments. Economically-motivated parties saw the opportunities in changing the boundaries of the firm; successful first-movers spawned imitators, hence a wave, which eventually subsided, often alongside deteriorating capital …