Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 43441 - 43470 of 1114568

Full-Text Articles in Entire DC Network

Exploring The Socio-Cultural Dynamics Of Nocturnal Urban Landscapes: A Case Study, Jie Kong Aug 2025

Exploring The Socio-Cultural Dynamics Of Nocturnal Urban Landscapes: A Case Study, Jie Kong

All Dissertations

This dissertation explores nighttime social leisure activities in public parks within urban working- and middle-class communities. As cities confront climate change, shifting work schedules, and post-pandemic lifestyles, neighborhood parks have gained renewed importance after dark, especially in areas where households have limited private space. These non-commercial nighttime uses are often overlooked in planning, design, and built environment studies, yet they play a vital role in fostering cultural identity, social connection, and community well-being.

Focusing on Williamsburg and Bushwick in Brooklyn, New York, this research investigates how public parks are used at night, by whom, and for what purposes. New York …


Online Multiobjective Optimization, Kristen Joyce Aug 2025

Online Multiobjective Optimization, Kristen Joyce

All Dissertations

Online optimization (OO) is an iterative process of decision making under uncertainty. At every step, a decision is made before the outcome of this decision is known. For the online optimization model, the objective function is unknown at the time the decision is being made. It is very likely that the taken decision is not optimal, so the decision maker incurs a loss, called regret, in every iteration. The goal of the online optimization algorithm is to compute a decision at every step so that the overall regret cost is minimized. In particular, the average regret produced by an ideal …


Flipping The Script?: The Development And Validation Of A Qualitative Framework For Identifying Key Cognitive And Attitudinal Components Of Conflict-Based Problem Representations, Kyle Christenson Aug 2025

Flipping The Script?: The Development And Validation Of A Qualitative Framework For Identifying Key Cognitive And Attitudinal Components Of Conflict-Based Problem Representations, Kyle Christenson

All Dissertations

When people work together, disagreements are inevitable. How someone understands a given conflict, specifically whether they see it as a shared problem or not, can shape how they respond and whether they look to resolve it collaboratively. Researchers have studied many aspects of conflict, like what causes it and the strategies people use to manage it. But we know much less about how people think about conflict in the first place and how those thoughts affect efforts to manage conflict. This research developed a tool to study how people describe conflicts in writing. It identifies key ideas and attitudes that …


From Cities To Ranches: Assessing Public Support For Jaguar (Panthera Onca) Conservation And Livestock Predation In Colombia, Luz Angelica Solano Aug 2025

From Cities To Ranches: Assessing Public Support For Jaguar (Panthera Onca) Conservation And Livestock Predation In Colombia, Luz Angelica Solano

All Dissertations

Jaguars are among the most emblematic large carnivores worldwide. Nonetheless, the species has declined by 25% in less than 25 years and their range has been reduced by 55%, approximately, primarily due to habitat loss from increasing agricultural development, retaliatory killings from human-jaguar conflict, and overhunting of their natural prey. Given the anthropogenic nature of these threats, developing effective coexistence strategies and public support for jaguar conservation are increasingly urgent for the continued persistence of this species. I conducted a scoping review to assess trends and gaps in the existing peer-reviewed literature, grey literature, and news articles related to human-jaguar …


Studies On The Effects Of Operator Fatigue On Performance, Trust, And Workload Demand In Human-In-The-Loop Ai-Enabled Drone Systems, Snowil Lopes Aug 2025

Studies On The Effects Of Operator Fatigue On Performance, Trust, And Workload Demand In Human-In-The-Loop Ai-Enabled Drone Systems, Snowil Lopes

All Dissertations

Civil infrastructure must be regularly inspected to ensure its safety and reliability. Traditionally, risk engineers performed these inspections manually and in person. However, with the introduction of drones equipped with artificial intelligence (AI), inspections of civil infrastructure can now be conducted remotely. These AI-enabled drones capture and analyze images, helping engineers monitor large and complex structures from a distance. However, working with integrated systems consisting of multiple drones, especially those with varying levels of reliability, can be challenging. Operators must divide their attention, determine how much to trust each drone, and manage mental workload, which can affect their performance. Another …


Empowering Employability: Voices Of Black Women Leveraging Community Cultural Wealth In An Undergraduate Agricultural Program, Rose Marie Somers Aug 2025

Empowering Employability: Voices Of Black Women Leveraging Community Cultural Wealth In An Undergraduate Agricultural Program, Rose Marie Somers

All Dissertations

Across the nation, agricultural industry professionals have bemoaned the shortage of qualified professionals, expressing an expanding need for graduates with a blend of discipline-specific and employability skills to advance the sector. Research indicates that the future of the US agriculture sector hinges on a diverse and skilled workforce. Yet, a paucity of literature exists on Black women's enduring legacy, experiences, and how they understand and develop 21st-century critical transferable professional competencies needed to address complex challenges in modern agriculture. Black women have a long tradition in agriculture and a wealth of cultural knowledge, skills and innovations that are untapped. This …


Improved Rumen Microbiome Interpretation Via Empirical Filtration Derived From Known Mock Microbiomes, Wesley A. Tom Aug 2025

Improved Rumen Microbiome Interpretation Via Empirical Filtration Derived From Known Mock Microbiomes, Wesley A. Tom

School of Biological Sciences: Dissertations, Theses, and Student Research

The rumen microbiome plays a critical role in ruminant health and performance. As a consequence, many studies investigate microbial community composition using 16S rDNA based sequencing. As such, data quality and data filtering are critical to accurately identify microbial community composition. In this study we use mock communities to empirically select data filtering parameters to reduce artifact populations and compared the effect of filtering using different bioinformatic pipelines using rumen bacterial community data. The filtering parameters identified provides consistent estimates of rumen microbial diversity, regardless of bioinformatic pipeline utilized and provides a more accurate view of microbiome structure and composition. …


Student Supports For Achieving College And Career Readiness, Edward C. Fletcher Jr., Turhan K. Carroll, Bo Hyun Lee, Carrie Burggraf Aug 2025

Student Supports For Achieving College And Career Readiness, Edward C. Fletcher Jr., Turhan K. Carroll, Bo Hyun Lee, Carrie Burggraf

Journal of College Access

School community members help to foster students’ college-going mindsets by creating and facilitating a college-going culture within the school. Based on our findings of a school district composed of a majority ethnically and racially diverse student body, we found the district to be successful in promoting social capital by way of a school stakeholder community. The school stakeholders leveraged social capital to promote a college and career going culture within the context of career pathway programs. This culture promoted a sense of belonging where students felt supported in achieving their goals of being college and career ready. Most notably, the …


Principal Self-Efficacy: A Qualitative Study, Vance E. Self Aug 2025

Principal Self-Efficacy: A Qualitative Study, Vance E. Self

Electronic Theses and Dissertations

This qualitative study explored elementary principals’ perspectives on the importance of selfefficacy in relation to management responsibilities, instructional leadership, and moral leadership as they impact student achievement measured by the STAAR in a Central Texas school district. The research addressed the growing challenges principals face in high-accountability environments, focusing on how their beliefs in their leadership abilities affect school performance and student outcomes. The purpose was to examine principals’ views on selfefficacy across three domains and to consider implications for leadership preparation, district support, and policy. The study was grounded in a constructivist paradigm and employed a qualitative case study …


Enhancing The Value Of Satellite Earth Observations For Coastal Management: Tools For Collaboration And Co-Development, Nicole Dejeet Bartlett Aug 2025

Enhancing The Value Of Satellite Earth Observations For Coastal Management: Tools For Collaboration And Co-Development, Nicole Dejeet Bartlett

Graduate Doctoral Dissertations

Despite unprecedented satellite Earth observation (EO) capabilities and free data availability, widespread adoption in coastal management remains limited due to persistent communication barriers between satellite experts and coastal practitioners. This dissertation addresses the fundamental challenge of translating satellite EO technical capabilities into management-relevant applications. Through synthesis of literature, stakeholder interviews, and two multi-year co-development case studies in Virginia's Middle Peninsula and Cape Cod, Massachusetts, this research identifies systematic barriers to satellite EO adoption and develops innovative frameworks for overcoming them.

The work argues for a common language between satellite product developers and coastal managers, identifying communication barriers spanning technical, institutional, …


From The Battlefield To The Archive: Tracing Testimony In Holocaust Memory, Tiana M. Taliep Aug 2025

From The Battlefield To The Archive: Tracing Testimony In Holocaust Memory, Tiana M. Taliep

War, Diplomacy, and Society (MA) Theses

This thesis portfolio examines the evolving role of testimony in shaping public memory of World War II and the Holocaust. As the last generation of eyewitnesses passes, societies increasingly rely on preserved, mediated forms of testimony to understand and remember traumatic pasts. Testimony, whether handwritten, oral, visual, or digital, is not a neutral historical record but an interpretive act shaped by cultural, political, and technological forces. This portfolio argues that testimony functions as evidence and expression: it transmits trauma across generations while simultaneously reflecting the changing frameworks through which war and genocide are remembered.

The portfolio explores testimony in personal, …


Effects Of Emotional Intelligence In Enhancing Team Collaboration And Conflict Resolution In Agile Project Management, Shaikh Muhammad Sinan Aug 2025

Effects Of Emotional Intelligence In Enhancing Team Collaboration And Conflict Resolution In Agile Project Management, Shaikh Muhammad Sinan

Harrisburg University Dissertations and Theses

In this study, I explored the use of emotional intelligence (EI) in enhancing team collaboration and conflict resolution within agile project management environments. Though agile methodologies have gained more popularity, most projects still suffer from interpersonal conflicts and communication failures that detract from project performance. Though the literature is particular to the dynamics of agile project management, little is known about the emotional and interpersonal dynamics that influence team effectiveness. I examined how EI skills such as self-awareness, self-regulation, empathy, and social skills influence team dynamics and project success. Guided by Daniel Goleman's Emotional Intelligence Framework, in this qualitative study, …


Sugar Functionalized Collagen Material For Local Modulation Of Innate Immunity, John Otto Martinez, Silvia Minardi, Laura Pandolfi, Xing Wang, Ennio Tasciotti, Kavindra V Singh, Cesar A Arias, Bruna Corradetti Aug 2025

Sugar Functionalized Collagen Material For Local Modulation Of Innate Immunity, John Otto Martinez, Silvia Minardi, Laura Pandolfi, Xing Wang, Ennio Tasciotti, Kavindra V Singh, Cesar A Arias, Bruna Corradetti

Faculty, Staff and Students Publications

Small alterations during the early stages of the innate immune response to an implant can drive large changes in adaptive immunity. Biomaterials for regenerative purposes can be engineered to modulate this immune response in beneficial ways. This study presents an innovative patch designed and functionalized to target the innate immunity at the implant site. Mannose moieties are incorporated into collagen patches, resulting in a technology called Local Immunotuning Patch (LIP), designed to directly interact with antigen presenting cells through their mannose receptor. In vitro, LIP shows anti-inflammatory effects on bone marrow-derived macrophages and inhibitory properties even on methicillin-resistant bacterial strains. …


Indoor Air Quality Conditions And Respiratory Virus Detections In Elementary Schools—Kansas City, Missouri, February–March 2023, Olivia M. Almendares, Jasmine D. Ruffin, Luke Gard, Rangaraj Selvarangan, Anjana Sasidharan, Dithi Banerjee, Nibha Sagar, Amanda Hayes, Sydnie Petty, Brian R. Lee, Chris T. Young, Janelle Potter, Shannon Tilsworth, Jennifer Goldman, Jennifer E. Schuster, Hannah L. Kirking Aug 2025

Indoor Air Quality Conditions And Respiratory Virus Detections In Elementary Schools—Kansas City, Missouri, February–March 2023, Olivia M. Almendares, Jasmine D. Ruffin, Luke Gard, Rangaraj Selvarangan, Anjana Sasidharan, Dithi Banerjee, Nibha Sagar, Amanda Hayes, Sydnie Petty, Brian R. Lee, Chris T. Young, Janelle Potter, Shannon Tilsworth, Jennifer Goldman, Jennifer E. Schuster, Hannah L. Kirking

Manuscripts, Articles, Book Chapters and Other Papers

Background/Objectives: Respiratory viruses circulate year-round and can spread indoors via inhalation of airborne particles. Effective ventilation and filtration may reduce transmission, particularly in school settings where children and staff spend significant time. This study examines the impact of indoor air quality (IAQ) and ventilation in schools on respiratory virus detection.

Methods: During February 27 to March 30, 2023, we assessed the relationship between IAQ and respiratory viruses in two Kansas City, Missouri, elementary schools by collecting bioaerosol samples, student and staff nasal swabs, and monitoring IAQ across 10 rooms (six classrooms, two common spaces, and two nurses’ offices). We calculated …


Impact Of Biodegradation On The Mechanical And Fatigue Properties Of 3d-Printed Pla Bone Scaffolds, Hamed Bakhtiari, Alireza Nouri, Muhammad Aamir, Mohadeseh Najafi, Majid Tolouei-Rad Aug 2025

Impact Of Biodegradation On The Mechanical And Fatigue Properties Of 3d-Printed Pla Bone Scaffolds, Hamed Bakhtiari, Alireza Nouri, Muhammad Aamir, Mohadeseh Najafi, Majid Tolouei-Rad

Research outputs 2022 to 2026

A proper degradation rate of bone scaffolds ensures optimal mechanical support and effective tissue regeneration. The present study examines the degradation effects of simulated body fluids (SBF) on the compressive and fatigue strength of 3D-printed PLA bone scaffolds. Scaffolds with varying surface-to-volume (S/V) ratios and identical porosity (60 %) were immersed in Hanks' solution for a maximum period of 30 days. Static and dynamic compression tests were performed at different immersion times to assess how S/V ratio influences the degradation process. CT images showed that scaffold pore structure remained interconnected after biodegradation, with no significant change in strut thickness or …


The Influence Of Surface Textural Properties And Adsorption Temperature On H2 Adsorption And Storage Performance Of Mil-88b(Fe) Mofs, Tawanda Matamba, Samira Sadeghi, Hussein Rasool Abid, Masoumeh Zargar, Alireza Keshavarz, Stefan Iglauer Aug 2025

The Influence Of Surface Textural Properties And Adsorption Temperature On H2 Adsorption And Storage Performance Of Mil-88b(Fe) Mofs, Tawanda Matamba, Samira Sadeghi, Hussein Rasool Abid, Masoumeh Zargar, Alireza Keshavarz, Stefan Iglauer

Research outputs 2022 to 2026

To advance the establishment of a stable H2 economy we need to solve the issue regarding its storage. The physicochemical properties of Metal Organic Frameworks (MOFs) make them suitable for H2 storage. Therefore, here, we synthesized two Iron-based MOFs (12-MIL-88 B(Fe), 24-MIL-88 B(Fe) at different reaction times (12 h and 24 h), to investigate the relationship between adsorption temperature and pressure with the material's surface textural properties towards H2 storage (at 30 °C, 0 °C, −78.5 °C, and −196.15 °C and from vacuum pressure to 55 bar). Results showed that at 30 °C and 0 °C adsorption temperature, H2 adsorption …


Advancement Of Biocarbon Materials In Sustainable Thermal And Electrochemical Energy Storage With Future Outlooks, Md Shahriar Mohtasim, Barun K. Das Aug 2025

Advancement Of Biocarbon Materials In Sustainable Thermal And Electrochemical Energy Storage With Future Outlooks, Md Shahriar Mohtasim, Barun K. Das

Research outputs 2022 to 2026

Biocarbon exhibits significant potential in thermal and electrochemical energy storage owing to its higher surface area, flexible porosity, and superior thermal stability, facilitating effective energy absorption, storage, and conversion. Additionally, its sustainable and cost-effective nature, derived from renewable biomass, aligns with the growing demand for eco-friendly solutions. There is not enough review work that offers comprehensive details on the unique properties of biocarbon (both animal and plant-derived), synthesis and characterization methods, the root level mechanism of biocarbon's interaction with phase change materials (PCMs) matrix, the generalization of thermal and electrochemical regulation with an emphasis on the benefits to the environment …


Impact Of Geometrical Dimensions On The Shear Behaviour Of Uhpc Deep Beams Reinforced With Steel And Synthetic Fibres, Hossein Mirzaaghabeik, Nuha S. Mashaan, Sanjay Kumar Shukla Aug 2025

Impact Of Geometrical Dimensions On The Shear Behaviour Of Uhpc Deep Beams Reinforced With Steel And Synthetic Fibres, Hossein Mirzaaghabeik, Nuha S. Mashaan, Sanjay Kumar Shukla

Research outputs 2022 to 2026

Ultra-high-performance concrete (UHPC) is recognized for its exceptional strength, durability, and versatility in engineering applications, making it a reliable composite in the construction industry. The incorporation of fibres into UHPC enhances its mechanical properties. Non-metallic fibres offer a promising alternative to steel fibres due to their resistance to corrosion. While much research has focused on the shear behaviour of UHPC reinforced with steel fibres, there is a notable gap in understanding the impact of non-metallic fibres. This study aims to address this gap by comparing the influence of synthetic fibres to steel fibres on the shear behaviour of UHPC through …


New Insights Into The Beliefs Of Secondary Pre-Service Teachers About Mathematics, Vesife Hatisaru, Olivia Johnston, Julia Collins, Benjamin Rott Aug 2025

New Insights Into The Beliefs Of Secondary Pre-Service Teachers About Mathematics, Vesife Hatisaru, Olivia Johnston, Julia Collins, Benjamin Rott

Research outputs 2022 to 2026

Teachers’ beliefs about mathematics can shape how they approach teaching, learning, and assessment in mathematics classrooms. This study examined Australian pre-service teachers’ (PSTs’) epistemological beliefs about mathematics. A total of 18 PSTs enrolled in Bachelor of Education and Master of Teaching (secondary mathematics) programs participated in the study by answering prompt questions in an open-ended questionnaire. The participants’ responses were content analyzed by categorizing the views evident in the responses into four pre-defined mathematical orientations: formalism-related, scheme-related, process-related, and application-related. Findings have shown that the dominant beliefs for the participants reflected process- or application- related orientations to mathematics. These findings …


Lithium Slag As A Supplementary Cementitious Material For Sustainable Concrete: A Review, Sajad Razzazan, Nuha S. Mashaan, Themelina Paraskeva Aug 2025

Lithium Slag As A Supplementary Cementitious Material For Sustainable Concrete: A Review, Sajad Razzazan, Nuha S. Mashaan, Themelina Paraskeva

Research outputs 2022 to 2026

The global cement industry remains a significant contributor to carbon dioxide (CO2) emissions, prompting substantial research efforts toward sustainable construction materials. Lithium slag (LS), a by-product of lithium extraction, has attracted attention as a supplementary cementitious material (SCM). This review synthesizes experimental findings on LS replacement levels, fresh-state behavior, mechanical performance (compressive, tensile, and flexural strengths), time-dependent deformation (shrinkage and creep), and durability (sulfate, acid, abrasion, and thermal) of LS-modified concretes. Statistical analysis identifies an optimal LS dosage of 20–30% (average 24%) for maximizing compressive strength and long-term durability, with 40% as a practical upper limit for tensile and flexural …


Mxenes At The Forefront: Advances In Energy Storage And Nanofluidic Applications, Zafar Said, Maham Aslam Sohail, Hassina Tabassum, Imran Haider Sajid, Hafiz Muhammad Ali, Furqan Jamil, Yogendra Kumar Mishra, A. K. Pandey Aug 2025

Mxenes At The Forefront: Advances In Energy Storage And Nanofluidic Applications, Zafar Said, Maham Aslam Sohail, Hassina Tabassum, Imran Haider Sajid, Hafiz Muhammad Ali, Furqan Jamil, Yogendra Kumar Mishra, A. K. Pandey

Research outputs 2022 to 2026

This review summarizes recent studies on MXenes and their composites regarding energy storage and nanofluidic devices. MXenes are a new family of two-dimensional transition metal carbides and nitrides that have gained much attention in recent times due to their excellent physicochemical properties, such as its exceptionally high electrical conductivity, even more than that of metals, thermal stability, hydrophilicity, high energy and power densities, tunable structures, and large surface area along with abundant electrocatalytically active sites. These features, along with larger interlayer gaps compared with graphene, point to the emergence of MXenes as energy storage alternatives. Synthesis, properties, and applications of …


Understanding The Role Of Sports Injury Management By Australian Osteopaths: A Cross Sectional Survey Of 992 Practitioners, Brett Vaughan, Jon Adams, Wenbo Peng, Lauren V. Fortington, Michael Fleischmann, Kylie Fitzgerald, Amie Steel, David Sibritt Aug 2025

Understanding The Role Of Sports Injury Management By Australian Osteopaths: A Cross Sectional Survey Of 992 Practitioners, Brett Vaughan, Jon Adams, Wenbo Peng, Lauren V. Fortington, Michael Fleischmann, Kylie Fitzgerald, Amie Steel, David Sibritt

Research outputs 2022 to 2026

Sport-related injuries are common presentations to primary care and hospital settings. Australian osteopaths practice mainly in private clinical settings in which the frequency of sport-related injury presentations, and how these injuries are managed, is unknown. The objective of the study was to describe the demographic, practice, and clinical management characteristics of Australian osteopaths who report often treating sport-related injuries. The study is a secondary analysis of data derived from the Australian osteopathy practice-based research network. Respondents indicated the frequency treating sports-related injuries in addition to other demographic, practice, and patient management characteristics. Backward logistic regression identified significant characteristics associated with …


Welding Fume In The Western Australian Mining Industry: Impact Of A Change To The Workplace Exposure Standard, Matthew Oosthuizen, Kerry Staples, Adelle Liebenberg, Kiam Padamsey, Marcus Cattani, Andy Mccarthy, Jacques Oosthuizen Aug 2025

Welding Fume In The Western Australian Mining Industry: Impact Of A Change To The Workplace Exposure Standard, Matthew Oosthuizen, Kerry Staples, Adelle Liebenberg, Kiam Padamsey, Marcus Cattani, Andy Mccarthy, Jacques Oosthuizen

Research outputs 2022 to 2026

The aim of this study was to analyse the Western Australian (WA) Safety Regulatory System (SRS) database to assess compliance of the WA mining sector regarding workers exposure to welding fumes and to identify trends over time. De-identified data analysed to assess the impact of reducing workplace exposure standards (WES) for general welding fumes on industry compliance. Historical trend analysis shows a shift from 100% compliance to 100% non-compliance, based on mean values and 95% confidence intervals, with exposure levels remaining consistent over time. These findings highlight the need for current, innovative engineering solutions, and raise questions about the validity …


Mining Waste In Asphalt Pavements: A Critical Review Of Waste Rock And Tailings Applications, Adeel Iqbal, Nuha S. Mashaan, Themelina Paraskeva Aug 2025

Mining Waste In Asphalt Pavements: A Critical Review Of Waste Rock And Tailings Applications, Adeel Iqbal, Nuha S. Mashaan, Themelina Paraskeva

Research outputs 2022 to 2026

This paper presents a critical and comprehensive review of the application of mining waste, specifically waste rock and tailings, in asphalt pavements, with the aim of synthesizing performance outcomes and identifying key research gaps. A systematic literature search yielded a final dataset of 41 peer-reviewed articles for detailed analysis. Bibliometric analysis indicates a notable upward trend in annual publications, reflecting growing academic and practical interest in this field. Performance-based evaluations demonstrate that mining wastes, particularly iron and copper tailings, have the potential to enhance the high-temperature performance (i.e., rutting resistance) of asphalt binders and mixtures when utilized as fillers or …


Behaviour Change Design For Reducing Plastic Usage By Perceived Similarity Nudge, Quentin Ehkirch, Ferdi Raharja, Udari Samaranayake, Ken Ichi Sawai, Akane Matsumae Aug 2025

Behaviour Change Design For Reducing Plastic Usage By Perceived Similarity Nudge, Quentin Ehkirch, Ferdi Raharja, Udari Samaranayake, Ken Ichi Sawai, Akane Matsumae

Research outputs 2022 to 2026

This study explores the influence of perceived similarity on pro-environmental behavior, focusing on plastic reduction. Participants' daily plastic use and reduction were tracked over 30 days via online chat software, with controlled nudges from an agent. Each group included two examinees and one agent. Behavioral data were analyzed to evaluate predictability from various perspectives and its relationship with behavioral change. Results showed significant differences in predictability based on perceived similarity, particularly during the first 10 days. Furthermore, nudges, consumption levels, and behavioral changes significantly affected predictability within the first 20 days. These findings contribute to understanding how perceived similarity can …


Crispr-Cas9 Engineering Of Human T Regulatory Cells – Design And Optimization Of A Manufacturing Process, Aiden L Moser, Clifford C Dacso, Yosi Gilad, David M Lonard, Bert W O'Malley Aug 2025

Crispr-Cas9 Engineering Of Human T Regulatory Cells – Design And Optimization Of A Manufacturing Process, Aiden L Moser, Clifford C Dacso, Yosi Gilad, David M Lonard, Bert W O'Malley

Faculty, Staff and Students Publications

Regulatory T cells (Tregs) are a subset of CD4 + T cells that comprise 5-10 % of the total CD4 + T cell population. Tregs, which are critically important for the maintenance of immune tolerance and immune homeostasis, are distinguished from other subtypes of CD4 + T cells by the expression of the transcription factor FOXP3. Because of the centrality to immunoregulation, Tregs have gained increasing attention as promising targets for clinical applications in autoimmune diseases, transplant rejection and graft-versus-host disease (GvHD). However, the essential role of Tregs in the complex network of the immune system implies their targeting as …


Biomarkers Of Cellular Senescence In Type 2 Diabetes Mellitus, Thomas A White, Elizabeth J Atkinson, Amanda Tweed, Allyson K Palmer, Nathan K Lebrasseur, Jad G Sfeir, Sundeep Khosla Aug 2025

Biomarkers Of Cellular Senescence In Type 2 Diabetes Mellitus, Thomas A White, Elizabeth J Atkinson, Amanda Tweed, Allyson K Palmer, Nathan K Lebrasseur, Jad G Sfeir, Sundeep Khosla

Faculty, Staff and Students Publications

Although animal studies have linked cellular senescence to the pathogenesis and complications of type 2 diabetes mellitus (T2DM), there is a paucity of corroborating data in humans. Thus, we measured a previously validated marker for senescent cell burden in humans, T‐cell expression of p16 mRNA, along with additional biomarkers, to compare the senescence phenotypes of postmenopausal control (lean, N = 37) and T2DM (N = 27) participants. To control for effects of obesity alone, we included a third group of obese but non‐diabetic women (N = 29) who were matched for body mass index to the T2DM participants. …


Data-Driven Approach To Dynamic Resting State Functional Connectivity In Post-Traumatic Stress Disorder: An Enigma-Pgc Ptsd Study, Courtney C Haswell, Chadi G Abdallah, Michael Angstadt, Justin T Baker, Hannah Berg, Jennifer U Blackford, Josh Cisler, Andrew S Cotton, Judith K Daniels, Nicholas D Davenport, Richard J Davidson, Terri A Deroon-Cassini, Seth G Disner, Wissam El Hage, Negar Fani, Jessie L Frijling, Evan M Gordon, Daniel W Grupe, Xiaofu He, Ryan Herringa, David Hofmann, Ashley A Huggins, Ahmed Hussain, Jonathan Ipser, Neda Jahanshad, Tanja Jovanovic, Milissa L Kaufman, Yoojean Kim, Anthony King, Saskia B J Koch, Sheri Koopowitz, Amit Lazarov, Lauren A M Lebois, Isreal Liberzon, Shmuel Lissek, Antje Manthey, Geoffrey May, Katie A Mclaughlin, Laura Nawijn, Steven M Nelson, Yuval Neria, Jack B Nitschke, Bunmi O Olatunji, Miranda Olff, Matthew Peverill, Yann Quidé, Orren Ravid, Kerry Ressler, Marisa Ross, Lauren E Salminen, Kelly Sambrook, Chiahao Shih, Anika Sierk, Scott R Sponheim, Dan J Stein, Jennifer Stevens, Thomas Straube, Benjamin Suarez-Jimenez, Paul M Thompson, Nic J A Van Der Wee, Steven J A Van Der Werff, Sanne J H Van Rooij, Mirjam Van Zuiden, Dick J Veltman, Robert R J M Vermeiren, Henrik Walter, Xin Wang, Hong Xie, Xi Zhu, Sigal Zilcha-Mano, Christine L Larson, Rajendra Morey Aug 2025

Data-Driven Approach To Dynamic Resting State Functional Connectivity In Post-Traumatic Stress Disorder: An Enigma-Pgc Ptsd Study, Courtney C Haswell, Chadi G Abdallah, Michael Angstadt, Justin T Baker, Hannah Berg, Jennifer U Blackford, Josh Cisler, Andrew S Cotton, Judith K Daniels, Nicholas D Davenport, Richard J Davidson, Terri A Deroon-Cassini, Seth G Disner, Wissam El Hage, Negar Fani, Jessie L Frijling, Evan M Gordon, Daniel W Grupe, Xiaofu He, Ryan Herringa, David Hofmann, Ashley A Huggins, Ahmed Hussain, Jonathan Ipser, Neda Jahanshad, Tanja Jovanovic, Milissa L Kaufman, Yoojean Kim, Anthony King, Saskia B J Koch, Sheri Koopowitz, Amit Lazarov, Lauren A M Lebois, Isreal Liberzon, Shmuel Lissek, Antje Manthey, Geoffrey May, Katie A Mclaughlin, Laura Nawijn, Steven M Nelson, Yuval Neria, Jack B Nitschke, Bunmi O Olatunji, Miranda Olff, Matthew Peverill, Yann Quidé, Orren Ravid, Kerry Ressler, Marisa Ross, Lauren E Salminen, Kelly Sambrook, Chiahao Shih, Anika Sierk, Scott R Sponheim, Dan J Stein, Jennifer Stevens, Thomas Straube, Benjamin Suarez-Jimenez, Paul M Thompson, Nic J A Van Der Wee, Steven J A Van Der Werff, Sanne J H Van Rooij, Mirjam Van Zuiden, Dick J Veltman, Robert R J M Vermeiren, Henrik Walter, Xin Wang, Hong Xie, Xi Zhu, Sigal Zilcha-Mano, Christine L Larson, Rajendra Morey

Faculty, Staff and Students Publications

Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven …


The Influence Of Ultra-Wide Field Fluorescein Angiography On The Diagnosis And Management Of Diabetic Retinopathy, Joelle A Hallak, Rawan Allozi, Aziz A Khanifar, Thanos D Papakostas, Christina Y Weng, Ronald C Gentile, J Peter Campbell, Jessica G Lee, Gennady Landa, Felix Y Chau, William F Mieler, Meenakashi Gupta, Amani A Fawzi, Judy E Kim, Jennifer I Lim, Robison Vernon Paul Chan Aug 2025

The Influence Of Ultra-Wide Field Fluorescein Angiography On The Diagnosis And Management Of Diabetic Retinopathy, Joelle A Hallak, Rawan Allozi, Aziz A Khanifar, Thanos D Papakostas, Christina Y Weng, Ronald C Gentile, J Peter Campbell, Jessica G Lee, Gennady Landa, Felix Y Chau, William F Mieler, Meenakashi Gupta, Amani A Fawzi, Judy E Kim, Jennifer I Lim, Robison Vernon Paul Chan

Faculty, Staff and Students Publications

Purpose: To study the influence of ultra-widefield fluorescein angiography (FA) on the diagnosis and management of diabetic retinopathy (DR).

Methods: Ten experts in DR completed an online survey in which they were asked to diagnose and manage DR cases using different imaging modalities. Experts independently reviewed 20 cases of DR and provided a diagnosis and management plan for each case, first based on ultra-widefield color-free and red-free images alone and again with the corresponding ultra-widefield FA images. Experts were polled on their diagnostic confidence, use of FA in clinical practice, and opinions on the value of ultra-widefield FA. Based on …


Integrated Stem Education For In-Service K-5 Elementary Teachers: Definitions, Self-Efficacy, And Teaching Practices, Amani Alhassan Aug 2025

Integrated Stem Education For In-Service K-5 Elementary Teachers: Definitions, Self-Efficacy, And Teaching Practices, Amani Alhassan

Electronic Theses and Dissertations

Increasing interest has been evident in implementing integrated science, technology, engineering, and mathematics (STEM) teaching in public schools. However, teachers need to be professionally prepared and increase self-efficacy in teaching integrated STEM in their classrooms. Little is known about how teachers' self-efficacy in teaching integrated STEM is related to teachers' practices around STEM integration, particularly in K-5 classrooms.

This convergent mixed-methods study involved surveys with open- and close-ended questions to determine the integrated STEM perceptions, definitions, classroom teaching practices, and self-efficacy level in teaching integrated STEM for 79 northeast Tennessee K-5 teachers. The study also investigated the relationship between teachers' …