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Spartan Daily, September 18, 2025, San Jose State University, School Of Journalism And Mass Communications Sep 2025

Spartan Daily, September 18, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 12


Ws-Fall: Fall Detection Attention-Based Approach Using Wifi And Inertial Data Modalities, Alaa Elmor, Bilal Arain Sep 2025

Ws-Fall: Fall Detection Attention-Based Approach Using Wifi And Inertial Data Modalities, Alaa Elmor, Bilal Arain

Sustainable Machine Intelligence Journal

According to the World Health Organization, 37 million falls occur every year which leads to sever injuries that require medical intervention. In addition, more than 600,000 people end up dying due to falls making them the second cause of accidental injury fatalities worldwide. Specifically, the elderly are more prone to fatal falls. Therefore, fall detection systems are needed to allow medical professionals to intervene in such cases. Various wearable and non-contact fall detection devices have been developed recently. Since non-contact Wi-Fi-based methods are widely available and non-intrusive, they are gaining popularity. In this paper, we propose a state-of-the-art fall detection …


Editorial: Wearable Technology: The New Ornament Of Network Physiology, Ankita Srivastava, Santosh Kumar Yadav Sep 2025

Editorial: Wearable Technology: The New Ornament Of Network Physiology, Ankita Srivastava, Santosh Kumar Yadav

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Introduction: The landscape of personal health monitoring is rapidly transforming, driven by advances in wearable technology. These devices, designed to be worn comfortably on the body, can capture real-time physiological data often difficult to obtain in traditional clinical settings. What began as a simple device for activity trackers for walking steps, heart rate, and blood oxygen saturation has evolved to play a crucial role in monitoring more complex physiological parameters critical for chronic disease management and preventative health.

The integration of artificial intelligence (AI) is further expanding the potential of wearable devices, enabling deeper analysis and predictive modeling of the …


Research On Real-Time Cgf Maneuvering State Generation Method Based On Random Finite Set, Xiaoyan Zhang, Ge Li, Peng Wang Sep 2025

Research On Real-Time Cgf Maneuvering State Generation Method Based On Random Finite Set, Xiaoyan Zhang, Ge Li, Peng Wang

Journal of System Simulation

Abstract: With the rapid development of sensor networks and other technologies, the acquisition of measurement data in the real physical space has become easier. How to utilize the measurement data from the real battlefield space to improve the accuracy and credibility of CGF simulation is the key issue to realize the CGF simulation combining virtual and real. The method is studied of using real measurement data to generate CGF model maneuvering state data in real time, in order to realize the virtual-real synchronization and real-time mapping between the real battlefield and CGF simulation system, and to provide environmental inputs for …


Benefit Distribution Optimization Model And Simulation For Multi-Mode Operation Of Industrial Software Platforms, Rongyu Guo, Xiaobin Li, Pei Jiang, Chuanjiang Li, Shanhui Liu, Jun Ma Sep 2025

Benefit Distribution Optimization Model And Simulation For Multi-Mode Operation Of Industrial Software Platforms, Rongyu Guo, Xiaobin Li, Pei Jiang, Chuanjiang Li, Shanhui Liu, Jun Ma

Journal of System Simulation

Abstract: Industrial software service platforms, characterized by low-cost investment, customized services, and rapid application deployment, have been widely adopted in small and medium-sized industrial clusters. The benefit distribution mechanism under multi-mode operation is crucial to the sustainable development of such platforms. To address the current challenges of single-operation models and the difficulty in adapting to diverse service scenarios, this study focuses on two core stakeholders that users and software developers to analyze the core service components and cooperation mechanisms of industrial software service platforms in a multi-mode operational environment. By integrating the function point method, a multi-mode user demand quantification …


Ai Test Modeling For Computer Vision System—A Case Study, Jerry Gao, Radhika Agarwal Sep 2025

Ai Test Modeling For Computer Vision System—A Case Study, Jerry Gao, Radhika Agarwal

Faculty Research, Scholarly, and Creative Activity

This paper presents an intelligent AI test modeling framework for computer vision systems, focused on image-based systems. A three-dimensional (3D) model using decision tables enables model-based function testing, automated test data generation, and comprehensive coverage analysis. A case study using the Seek by iNaturalist application demonstrates the framework’s applicability to real-world CV tasks. It effectively identifies species and non-species under varying image conditions such as distance, blur, brightness, and grayscale. This study contributes a structured methodology that advances our academic understanding of model-based CV testing while offering practical tools for improving the robustness and reliability of AI-driven vision applications.


Socio-Economic Risk Of Rising Compound Precipitation-Wind Extremes In San Francisco Bay Area, Nikhil Kumar, Gregory Brian Pasternack, Yufang Jin, Serena Alexander, Zhihao Wang, Costanza Rampini, Rune Storesund, Chris Lim, Stephanie Moreno, Igor Lacan Sep 2025

Socio-Economic Risk Of Rising Compound Precipitation-Wind Extremes In San Francisco Bay Area, Nikhil Kumar, Gregory Brian Pasternack, Yufang Jin, Serena Alexander, Zhihao Wang, Costanza Rampini, Rune Storesund, Chris Lim, Stephanie Moreno, Igor Lacan

Faculty Research, Scholarly, and Creative Activity

Compound precipitation-wind extremes (CPWEs) pose significant socio-economic challenges in urban areas, with the most severe impacts often felt by vulnerable populations. While CPWE studies have often focused on large-scale assessments, localised urban contexts, at a scale of a city and its suburban surroundings, remain understudied, particularly in terms of how CPWEs might differentially impact different socio-economic communities. This study aims to advance understanding of how CPWEs interact with social vulnerability at a localised scale, using the San Francisco Bay Area (SFBA)—a global hotspot for CPWEs with diverse climates, physiography, and socio-economic factors—as a test case. Daily precipitation and wind speed …


September 2025 Academic Affairs Minutes, University Of Nebraska At Kearney Academic Affairs Committee Sep 2025

September 2025 Academic Affairs Minutes, University Of Nebraska At Kearney Academic Affairs Committee

Academic Affairs Committee Minutes

No abstract provided.


Connecting Innovation And Trust Through Translational Sciences – A Need For A Community Focus And Effective Education Strategiess, Filipa Godoy-Vitorino, Michelle Borrero, Josué Pérez-Santiago, Rubén García-García, Candelaria Gomez-Manzano Sep 2025

Connecting Innovation And Trust Through Translational Sciences – A Need For A Community Focus And Effective Education Strategiess, Filipa Godoy-Vitorino, Michelle Borrero, Josué Pérez-Santiago, Rubén García-García, Candelaria Gomez-Manzano

Faculty, Staff and Student Publications

Report of a conference held in Puerto Rico, this article highlights how interdisciplinary translational science-anchored in education, public trust, and equity-can accelerate innovation in cancer therapy while empowering underserved communities through inclusive training, collaboration, and research participation.


Semilunar Valve Replacement With A Telescoping Arterial Trunk Valve, Edo Bedzra, Herra Javed, James E. O'Brien, Taufiek Konrad Rajab Sep 2025

Semilunar Valve Replacement With A Telescoping Arterial Trunk Valve, Edo Bedzra, Herra Javed, James E. O'Brien, Taufiek Konrad Rajab

Manuscripts, Articles, Book Chapters and Other Papers

A bicuspid aortic valve, from autologous tissue, with growth potential can be constructed using the simple, and reproducible telescoping arterial trunk technique.


A Growing Threat Of Multi-Hazard Cascades Highlighted By The Birch Glacier Collapse And Blatten Landslide In The Swiss Alps, Nazimul Islam, Jonathan L. Carrivick, Tom Coulthard, Matthew Westoby, Stuart Dunning, Saskia Gindraux Sep 2025

A Growing Threat Of Multi-Hazard Cascades Highlighted By The Birch Glacier Collapse And Blatten Landslide In The Swiss Alps, Nazimul Islam, Jonathan L. Carrivick, Tom Coulthard, Matthew Westoby, Stuart Dunning, Saskia Gindraux

School of Geography, Earth and Environmental Sciences

Rapid atmospheric warming, especially at high altitude, leads to alpine mountain landscapes becoming more vulnerable to mass movements and consequently unstable. For example, decay of mountain permafrost contributes to rockfalls, landslides and debris flows; glaciers are retreating and losing mass at alarming rates, exposing unstable slopes that are more likely to fail; and meltwater, which collects in a growing number of glacial lakes, can pose an outburst flood hazard, putting communities and infrastructure downstream at risk of damage. Occurring now with increasing frequency, these natural phenomena often combine to create complex multi-hazard cascades that are more powerful and have a …


Gc-Ms-Based Metabolomics For Understanding The Metabolite Profile Of Mopane Worm (Gonimbrasia Belina) And Sorghum (Sorghum Bicolor L), Mpho Sebabiki Maleke, Tumisi Beiri Jeremiah Molelekoa, Jonathan Wilkin, Xi Feng, Moira Ledbetter, Oluwafemi Ayodeji Adebo Sep 2025

Gc-Ms-Based Metabolomics For Understanding The Metabolite Profile Of Mopane Worm (Gonimbrasia Belina) And Sorghum (Sorghum Bicolor L), Mpho Sebabiki Maleke, Tumisi Beiri Jeremiah Molelekoa, Jonathan Wilkin, Xi Feng, Moira Ledbetter, Oluwafemi Ayodeji Adebo

Faculty Research, Scholarly, and Creative Activity

Edible insects are nutritious, having high levels of protein, essential amino acids, healthy fats, vitamins, and minerals. In areas where sorghum is a primary crop, mixing this gluten-free grain with protein-rich insect powder provides a novel approach to making nutrient-rich products. Understanding the sorghum and mopane worm flours' metabolomic changes during bioprocessing can however, enhance their nutritional value and food safety. The research investigated metabolite compounds that are found in raw and processed (fermented, malted (sorghum), and ultrasonicated) mopane worms and sorghum. In the study, sorghum grains were traditionally fermented and malted at 35°C for 48 h and ultrasonicated for …


Uav-Based Transport Management For Smart Cities Using Machine Learning, Sweekruthi Balivada, Jerry Gao, Yuting Sha, Manisha Lagisetty, Damini Vichare Sep 2025

Uav-Based Transport Management For Smart Cities Using Machine Learning, Sweekruthi Balivada, Jerry Gao, Yuting Sha, Manisha Lagisetty, Damini Vichare

Faculty Research, Scholarly, and Creative Activity

Highlights: What are the main findings? A smart transport management system based on UAV data integrating advanced machine learning and deep learning techniques is proposed to enhance road anomaly detection and severity classification. The system employs a comprehensive multi-stage framework, integrating a high-precision obstacle detection model, six specialized severity classification models, and an aggregation model to deliver accurate anomaly assessment, enabling strategic, data-driven road maintenance and enhanced transportation safety. What is the implication of the main finding? A scalable and efficient solution is proposed to enhance road safety and optimize transportation management through intelligent anomaly detection and severity assessment. This …


September 2025 Cafe Newsletter, Elizabeth Reardon Sep 2025

September 2025 Cafe Newsletter, Elizabeth Reardon

CAFE Faculty Newsletters

Center for Advancing Faculty Excellence (CAFE) newsletter Sept. 2025.


Allosteric Control Overcomes Steric Limitations For Neutralizing Antibodies Targeting Conserved Binding Epitopes Of The Sars-Cov-2 Spike Protein: Exploring The Intersection Of Binding, Allostery, And Immune Escape With A Multimodal Computational Approach, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker Sep 2025

Allosteric Control Overcomes Steric Limitations For Neutralizing Antibodies Targeting Conserved Binding Epitopes Of The Sars-Cov-2 Spike Protein: Exploring The Intersection Of Binding, Allostery, And Immune Escape With A Multimodal Computational Approach, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Understanding the atomistic basis of multi-layer mechanisms employed by broadly reactive neutralizing antibodies of the SARS-CoV-2 spike protein without directly blocking receptor engagement remains an important challenge in coronavirus immunology. Class 4 antibodies represent an intriguing case: they target a deeply conserved, cryptic epitope on the receptor-binding domain yet exhibit variable neutralization potency across subgroups F1 (CR3022, EY6A, COVA1-16), F2 (DH1047), and F3 (S2X259). The molecular basis for this variability is not fully understood. Here, we employed a multi-modal computational approach integrating atomistic and coarse-grained molecular dynamics simulations, binding free energy calculations, mutational scanning, and dynamic network analysis to elucidate …


Rat Somatic Genome Editing Enables Er+ Breast Cancer Modeling, Wen Bu, Tobie Lee, Meenakshi Anurag, Yunfeng Ding, Ruixin Xu, Lillian He, Alexandria Z Bu, Chandandeep Nagi, Carolina Gutierrez, Susan Hilsenbeck, Chonghui Cheng, Bing Zhang, Shixia Huang, Jianming Xu, C Kent Osborne, Arun Sreekumar, Eric Chang, Chad J Creighton, Xiang Zhang, Yi Li Sep 2025

Rat Somatic Genome Editing Enables Er+ Breast Cancer Modeling, Wen Bu, Tobie Lee, Meenakshi Anurag, Yunfeng Ding, Ruixin Xu, Lillian He, Alexandria Z Bu, Chandandeep Nagi, Carolina Gutierrez, Susan Hilsenbeck, Chonghui Cheng, Bing Zhang, Shixia Huang, Jianming Xu, C Kent Osborne, Arun Sreekumar, Eric Chang, Chad J Creighton, Xiang Zhang, Yi Li

Faculty, Staff and Students Publications

Genetically engineered mouse models have advanced cancer research but often fail to capture key features of certain human tumors. Rats, with distinct physiology and tumor biology, offer a powerful alternative, yet their use has been constrained by technical barriers to genome editing. Here, we report efficient somatic genome editing in rats, enabling both Indel and substitution mutations. We then apply this approach to model estrogen receptor (ER)-positive breast cancer, which accounts for ~70% of human cases but remains poorly represented in mice. The resulting rat tumors reproduce hallmarks of human ER+ breast cancer, including ductal histology, hormone responsiveness, and immune-microenvironmental …


Artificial Intelligence And Collaborative Learning: Impacts On Creativity, Critical Thinking, And Problem-Solving, Abderrahim Agnaou, Hayat El Asri Sep 2025

Artificial Intelligence And Collaborative Learning: Impacts On Creativity, Critical Thinking, And Problem-Solving, Abderrahim Agnaou, Hayat El Asri

Journal of Educational Research and Practice

The rapid development of large anguage models (LLMs) has sparked growing interest in their potential to transform education. This study explores how LLMs influence collaborative learning, focusing on student creativity, critical thinking, problem-solving, and collective intelligence. Specifically, it investigates whether artificial intelligence (AI)–assisted group work enhances or hinders these aspects of the learning process. We used a mixed-methods approach, combining quantitative and qualitative data from surveys, structured interviews, and analysis of student project outputs. We collected data from 102 undergraduate students via questionnaires and 15 follow-up interviews, which offered deeper insight into their experiences using LLMs in team-based projects. The …


Seeing Google At 25, Paul A. Soukup S.J. Sep 2025

Seeing Google At 25, Paul A. Soukup S.J.

Communication Research Trends

Seeing Google at 25

1. History . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

A. Fits and starts to dominating the world . . . . . 5

2. Google in the Eyes of Scholars: Google Services 8

A. Digital library . . . . . . . . . . . . . . . . . . . . . . . . . 8

B. Google Earth and Google Maps . …


Evaluating User Engagement In A Research Information Management System At A Large Research-Intensive University, Rachel Miles, Emily Mazure, Mengyu Yin, Ben Greenwald Sep 2025

Evaluating User Engagement In A Research Information Management System At A Large Research-Intensive University, Rachel Miles, Emily Mazure, Mengyu Yin, Ben Greenwald

International Forum on Expert Finder Systems

At the heart of a valued research information management (RIM) service is a well-curated set of easily accessible and trustworthy data that describe an institution's research activity. The cultivation of those data into beneficial use cases requires ongoing collaboration among myriad stakeholders from within the research development community (librarians, faculty administrators, communications specialists, technology licensing agents, facility and equipment managers, IT personnel, etc.).

This presentation will explore the social interoperability involved in nurturing the library-managed RIM services at two major midwestern research universities—from the partnerships involved in unifying previously siloed sources of data to the use cases supported in each …


Managing Digital Visibility, Ben Medeiros Sep 2025

Managing Digital Visibility, Ben Medeiros

Communication Research Trends

No abstract provided.


Charting A Constellation Of Rims Social Interoperability: Stakeholder Engagement At Two Midwestern Universities, Mark Zulauf, Elizabeth Schwartz Sep 2025

Charting A Constellation Of Rims Social Interoperability: Stakeholder Engagement At Two Midwestern Universities, Mark Zulauf, Elizabeth Schwartz

International Forum on Expert Finder Systems

At the heart of a valued research information management (RIM) service is a well-curated set of easily accessible and trustworthy data that describe an institution's research activity. The cultivation of those data into beneficial use cases requires ongoing collaboration among myriad stakeholders from within the research development community (librarians, faculty administrators, communications specialists, technology licensing agents, facility and equipment managers, IT personnel, etc.).

This presentation will explore the social interoperability involved in nurturing the library-managed RIM services at two major midwestern research universities—from the partnerships involved in unifying previously siloed sources of data to the use cases supported in each …


Promoting The Value Of Research With An Efs: Nsf Tip Project, Randy Love Sep 2025

Promoting The Value Of Research With An Efs: Nsf Tip Project, Randy Love

International Forum on Expert Finder Systems

At a time of dramatic change, many universities, medical facilities, and government labs are searching for ways to meet the goals and objectives placed upon them. Being able to demonstrate to funders, politicians, and the public the direct impact research has on the world in which we live becomes a critical necessity. This session will provide a quick overview of how Expert Finders Systems can help meet the specific goals as provided to the White House Office of Science and Technology Policy (OSTP) and share an overview of how one funder, NSF TIP, has partnered with Elsevier to help meet …


Toward An Understanding Of Tax Complexity, Daniel Schaffa Sep 2025

Toward An Understanding Of Tax Complexity, Daniel Schaffa

Florida Tax Review

The study of tax complexity has reached consensus on two things. First, complexity pervades the U.S. tax system. And second, it is not always clear what tax complexity means. Indeed, it is common practice for tax complexity scholarship to note the absence of a universal tax complexity definition and then conduct its inquiry without one. A universal definition of tax complexity has proven elusive because tax complexity means many different (although often related) things. This has made the tax policy analysis of complexity challenging. As an alternative to a definition, this Article proposes a framework with four elements for considering …


Do Tax Judges Favor The Tax Authority?, Orli Oren-Kolbinger Sep 2025

Do Tax Judges Favor The Tax Authority?, Orli Oren-Kolbinger

Florida Tax Review

Judges and judicial systems have become more specialized in response to increasing legal complexity. While the theoretical literature has discussed judicial specialization extensively, deliberating its pros and cons and its implications—arguably an appealing background for empirical investigation—few empirical studies have attempted to quantify the relationship between judicial specialization and case outcomes. This Article fills that lacuna. It analyzes a hand-coded dataset of tax cases in which rulings were made by both specialized tax judges and generalist judges in Israeli District Courts. Its main finding is that specialized tax judges are more inclined than generalist judges toward the Tax Authority. It …


Stream Temperature Responses To Summer Urban Rain Events Along The Savannah River, Joseph E. Wermter, Vivian L. Turner, Max K. Appelbaum, James M. Shepherd, Jacob Z. Lott Sep 2025

Stream Temperature Responses To Summer Urban Rain Events Along The Savannah River, Joseph E. Wermter, Vivian L. Turner, Max K. Appelbaum, James M. Shepherd, Jacob Z. Lott

Journal of South Carolina Water Resources

The hydrological urban heat island (HUHI) is a recent facet of the urban heat island (UHI), describing thermal enhancement of bodies of water in response to urbanization. Although the forefront of this work has been studied for large Metropolitan areas, this effect on developing cities is currently unknown. To locally measure and quantify HUHI effects in a developing city, we utilized Multi-Radar Multi Sensor (MRMS) radar-derived rainfall data to estimate rainfall in the Augusta Metropolitan Area (AMA) and the Savannah Metropolitan Area (SMA), two developing communities adjacent to the Savannah River. We analyzed mean temperature trends of two stream gauges …


Contextual Analysis Of Physical-Tactical Match Performance Demands In Elite U21 Soccer Players, Craig Davies, Christian Vassallo, Ben Ryan, Piotr Zmijewski, Rafael Oliveria, José E. Teixeira, Alexandre Moreira, Ryland Morgans Sep 2025

Contextual Analysis Of Physical-Tactical Match Performance Demands In Elite U21 Soccer Players, Craig Davies, Christian Vassallo, Ben Ryan, Piotr Zmijewski, Rafael Oliveria, José E. Teixeira, Alexandre Moreira, Ryland Morgans

Baltic Journal of Health and Physical Activity

Background: Soccer matches include physical and tactical factors, yet limited research has integrated physical-tactical variables involving U21 soccer players. This study examined how different phases of play influence physical intensity in elite U21 soccer players. Materials and Methods: Twelve professional development league matches involving 29 male U21 soccer players (106 observations) were analysed. Players wore 10 Hz GPS units to derive relative (m/min) physical metrics during six phases of play. Phases and positions were compared using repeated‑measures ANOVA and one‑way ANOVA. Results: Players covered significantly greater high-speed running per minute (HSR/min) during the final third compared to build-up (p …


Beyond Description: Interrogating Narrative Elements In Archival Finding Aids, David J. Williams, Richard Kearney Sep 2025

Beyond Description: Interrogating Narrative Elements In Archival Finding Aids, David J. Williams, Richard Kearney

Journal of Contemporary Archival Studies

As the archival profession evolves, attention is increasingly paid to the usability of its resources and services. User Experience, or UX, is a contemporary design practice gaining prominence among archivists interested in addressing usability. Information design, the process of organizing and presenting information for efficient and effective use, is a component of UX incorporating both the presentation and content of communication instruments, with plain language writing guidelines applied toward achieving this goal. A prominent information artifact produced by archivists is the finding aid, describing and inventorying archival collections. Those components of finding aids providing “access points” into collections—communicating the …


Between Foreignization And Domestication: A Corpus-Based Study Of The Translation Of Food-Related Cultural References In The Arabic Subtitling Of 90 Hollywood Films, Eisa Ahmad Saeed Asiri Sep 2025

Between Foreignization And Domestication: A Corpus-Based Study Of The Translation Of Food-Related Cultural References In The Arabic Subtitling Of 90 Hollywood Films, Eisa Ahmad Saeed Asiri

UB Journal for Humanities

This paper explores the translation of food-related cultural references (FCRs) from spoken English into Arabic subtitles based on analysis of a corpus-driven mixed-method of 90 Hollywood films. Using the AVT-FoodCorpus90, a 1.4-million-word English-Arabic parallel corpus, the study examines how subtitlers work to balance foreignization and domestication in the process of translating culturally specific food items. The results reveal that the most popular strategy is that which relies on foreignization through transference (29.8%), followed by literal translation (25.1%) and intratextual glosses (15.4%), creating a new trend in Arabic subtitling that promotes cultural visibility and creates intercultural interaction. However, domestication remains necessary, …


Precision Nanomedicine For Anxiety: Challenges, Opportunities, And Future Directions In Targeted Drug Delivery, Sehrabpreet Singh, Amanpreet Singh, Shruti Chittu, Shailesh Sharma Sep 2025

Precision Nanomedicine For Anxiety: Challenges, Opportunities, And Future Directions In Targeted Drug Delivery, Sehrabpreet Singh, Amanpreet Singh, Shruti Chittu, Shailesh Sharma

Journal of Food and Drug Analysis

Nanoparticle-based drug delivery system represents one of the challenging strategies suggested to improve anxietydisorder therapeutic approaches, clinic challenges of delayed action, side effect-free designing and poor patientcompliance. Traditional pharmacological agents can increase drug bioavailability and target specific brain regions,whereas nanoparticle-mediated controlled release offers enhanced precision and sustained action. The others in thisreview concentrate on several kinds of nanoparticle, including lipid-based, polymeric-metallic, and responsive nano-particles, their use in anxiety medication. In addition, emphasis is placed on precision medicine that pertain the delivery of treatment based on an individual's genetic, environmental and lifestyle aspects. Also, it is looked into how artificial intelligence …


Targeted Nanosponge-Based Treatment For Pulmonary Hypertension: A Novel Approach, Jashanpreet Kaur, Gursimran Kaur, Chamanpreet Kaur, Sandeep Kumar Sep 2025

Targeted Nanosponge-Based Treatment For Pulmonary Hypertension: A Novel Approach, Jashanpreet Kaur, Gursimran Kaur, Chamanpreet Kaur, Sandeep Kumar

Journal of Food and Drug Analysis

Pulmonary Hypertension (PH) is a progressive and potentially fatal condition marked by high pulmonary arterypressure, resulting in heart failure and reduced oxygenation. Despite advancements in treatments, therapeutic optionsfor PH remain limited, particularly in cases resistant to conventional therapies. In biomedical research, nanotechnologyhas become a potential area of study, presenting novel approaches to drug delivery and tissue targeting. Nanosponges, aclass of nanoparticles with porous structures, have gained attention for their ability to encapsulate therapeutic agents,enhance drug stability, and provide controlled release. Nanosponges can be engineered to deliver vasodilators, anti-inflammatory drugs, and gene therapies directly to the pulmonary vasculature, minimizing systemic side …