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Lysosomal Lrrc8 Complex Impacts Lysosomal Ph, Morphology, And Systemic Glucose Metabolism, Ashutosh Kumar, Yonghui Zhao, Litao Xie, Rahul Chadda, John D Tranter, Ryan T Mikami, Nihil Abraham, Juan Hong, Ethan Feng, David R Rawnsley, Haiyan Liu, Gretchen Meyer, Abhinav Diwan, Rajan Sah, Et Al.

2020-Current year OA Pubs

The lysosome integrates anabolic signaling and nutrient sensing to regulate intracellular growth pathways. The leucine-rich repeat-containing 8 (LRRC8) channel complex forms a lysosomal anion channel and regulates PI3K-AKT-mTOR signaling, skeletal muscle differentiation, growth, and systemic glucose metabolism. Here, we define the endogenous LRRC8 subunits localized to a subset of lysosomes in differentiated myotubes. We show that LRRC8A affects leucine-stimulated mTOR; lysosome size; number; pH; expression of lysosomal proteins LAMP2, P62, and LC3B; and lysosomal function. Mutating an LRRC8A lysosomal targeting dileucine motif sequence (LRRC8A-L706A;L707A) in myotubes recapitulates the abnormal AKT signaling and altered lysosomal morphology and pH observed in LRRC8A …

Naming Chemicals: From Fear To Flourishing, Carl P. Fictorie

Faculty Work Comprehensive List

"A closer look at the structure of chemical names will invite us into a deeper understanding of the chemical aspect of creation and enable us to be better stewards of creation."

Posting about the benefits of scientific knowledge from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Naming Chemicals

The Addition Of Chinese Herbal Medicines Is Effective As A Prophylactic Treatment Against Dental Diseases For Sjögren’S Syndrome Patients: Insight From Real-World Database, Ching-Ya Juan, Wei-Jen Chen, Hanoch Livneh, Ming-Chi Lu, Tzung-Yi Tsai

Leadership, Learning and Counseling Faculty Publications and Presentations

Background and Objectives:

Sjögren’s syndrome (SS) is a chronic autoimmune disease that affects the salivary glands and increases the risk of developing dental diseases (DDs). Chinese herbal medicines (CHMs) represent a promising alternative strategy for SS treatment; however, the association between CHMs and DD risk has not been confirmed. In this retrospective, cohort-based, nested case-control study, we explored whether or not combining CHMs with routine treatments for SS can reduce the chance of DDs.

Materials and Methods:

In the beginning, we recruited subjects aged 20–80 years with newly diagnosed SS who were free of DDs between 2001 and …

Carbonated High-Al Steel Slag As Supplementary Cementitious Material: Synergy Of Carbonation At Elevated Temperature And Addition Of Gypsum, Nannan Zhang, Gao Deng, Wenyu Liao, Chuanlin Hu, Lingyu Chi, Hongyan Ma

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

High-Al steel slags, such as ladle metallurgy furnace (LMF) slag, substantially retard the early hydration of cement when incorporated into cement pastes, primarily due to the high mayenite content. In this study, carbonation of slag at elevated temperatures of 60°C and 80°C, combined with gypsum addition, was proposed to synergistically mitigate the retardation effect and enhance the early-age strength of cement pastes. The physical and chemical properties of slags carbonated at various temperatures were analyzed to elucidate their impact on cement performance as a supplementary cementitious material. The results indicate that higher temperatures enhance carbonation reactivity, accelerating the carbonation of …

Common Ground Newsletter Fall 2025, Missouri University Of Science And Technology

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Use Of Artificial Intelligence (Ai) In Academic Contexts

Academic Affairs Policies

This policy establishes guidance for the responsible, ethical, and transparent use of Artificial Intelligence (AI) tools at Georgia Southern University (University) including in teaching, learning, assessment, classroom activities, University community service, research, creative activity, scholarly communication, and administrative activities, while encouraging innovation, academic freedom, and appropriate autonomy while maintaining compliance with all data security and privacy regulations. This policy ensures that the University complies with Board of Regents (BOR) Policy 6.28 Artificial Intelligence in Academic Context; federal, state, and international laws; and industry standards and best practices.

Leading Through Times Of Financial Uncertainty In Nonprofit Organizations, Lakisha A. Dent-Gordon

Walden Dissertations and Doctoral Studies

This macro analysis examines the leadership effectiveness of a CEO within a nonprofit re-entry organization dedicated to reducing the 36% recidivism rate in a Southwestern U.S. state. The organization serves up to 50 clients recently released from the state prison system, offering housing and support services. The organizations leadership faced imminent closure due to a financial crisis driven by limited funding, high employee turnover, and a lack of community partnerships, allowing for an examination of the CEO’s response to the crisis. The quantitative study includes a review of peer-reviewed literature, assessments based on the Baldrige Framework of Excellence, and interviews …

Strategies To Improve The Financial Success For Minority And Small Business Owners, Kimberly D. Stone

Walden Dissertations and Doctoral Studies

Although minority small business owners have a substantial influence on the U.S. economy, they often face significant financial obstacles. Minority small business owners are concerned with the history of unfair lending practices in the United States, as access to adequate capital is crucial to achieving business success. Grounded in Donaldson’s pecking order theory, the purpose of this qualitative pragmatic inquiry was to explore effective financial strategies that some minority small business owners used to sustain their businesses. The project participants were six minority small business leaders who had more than 5 years of experience from various industries in South Florida. …

Women Clergy Members' Perceptions Of Mentorship Strategies For Leader Development, Linda Ann Brady

Walden Dissertations and Doctoral Studies

According to recent studies, women were underrepresented in senior leadership in the global Christian church, and leadership pathways for the development of women were often lacking. The local problem within the International Christian Church (ICC) was a lack of understanding of holistic mentoring strategies that support the development of women clergy members, which could help fill the current leadership gap. Guided by Dahlvig and Longman’s model of women’s leadership development, the purpose of this basic qualitative study was to explore the perceptions of women clergy regarding holistic mentoring strategies that might increase the number of women in leadership within the …

Using Drone And Ai To Map Leaf Water Potential And Stem Water Potential For Water Stress Management In Commercial Vineyards, Alfonso F. Torres-Rua

Funded Research Records

No abstract provided.

Identifying The Big Questions In Paleontology: A Community-Driven Project, Tracy Aze

School of Biological and Marine Sciences

Paleontology provides insights into the history of the planet, from the origins of life billions of years ago to the biotic changes of the Recent. The scope of paleontological research is as vast as it is varied, and the field is constantly evolving. In an effort to identify “Big Questions” in paleontology, experts from around the world came together to build a list of priority questions the field can address in the years ahead. The 89 questions presented herein (grouped within 11 themes) represent contributions from nearly 200 international scientists. These questions touch on common themes including biodiversity drivers and …

Space: The Final Frontier (For State Power): The History Of The East India Company And The Future Of Outer Space, Richard Culbert

International Law Studies

Outer space may be the last domain where States largely lack the capability to use coercive force as an instrument of State control. In all areas of the globe, major powers have militaries and police forces that far exceed the capability of even the largest corporations. As corporations take an increasingly large role in outer space commerce it is likely that these private actors will develop a capacity to use force that quickly surpasses even the most powerful States.

To date there has been little analysis of this future phenomenon by legal scholars. Perhaps as a result, the current international …

Cfd Modeling Of Lateral Spillway Flow In End-Of-Bridge Deck Drainage, Serox Sukupayo

Electronic Theses and Dissertations Archive

The Tennessee Department of Transportation (TDOT) has established a new standard for bridge-deck drainage, which features a side-inlet positioned at the end of the bridge adjacent to the roadway. This inlet serves as a lateral weir or spillway, connecting to a riprap-lined flume or chute that extends down the embankment. The hydraulic performance of this standard - encompassing capture efficiency, bypassed flow, water spreads and depths on the pavement, flow depths and velocities in the flume, and the potential for embankment erosion - must be evaluated across a variety of bridge conditions, including longitudinal and cross slopes, as well as …

Distinct Intrinsic And Extrinsic Factors Differentially Regulate Skeletal Stem Cells In Calvaria Versus Long Bones During Bone Regeneration, Jea Solidum, Kohei Yamasaki, Youngjae Jeong, Laura Ortinau, Francisco Heralde, Dongsu Park

Faculty, Staff and Students Publications

Calvarial suture skeletal stem cells (Su-SSCs) are a distinct stem cell population for craniofacial bone formation by intramembranous ossification, compared to long bone periosteal SSCs (LB-PSSCs) with endochondral (osteochondrogenic) ossification. However, whether SSC intrinsic or extrinsic factors affect their differentiation process has not been well elucidated. Here, using an inducible Prx1-CreER-EGFP+/−;Rosa26-tdTomato mouse model, we observed that endogenous Prx1+ Su-SSCs and their orthotopic transplantation into calvarial injury do not form cartilage intermediates at the injury sites, while the transplantation of Prx1+ LB-PSSCs into LB injury induces osteochondrogenic differentiation, respectively. However, the heterotopic transplantation of Prx1+ Su-SSCs (Su-SSCs …

Aggrebots: Configuring Ciliabots Through Guided, Modular Tissue Aggregation, Dhruv Bhattaram, Kian Golestan, Xuanshuo Zhang, Shihong Yang, Zhuowei Gong, Steven L Brody, Amjad Horani, Victoria A Webster-Wood, Amir Barati Farimani, Xi Ren

2020-Current year OA Pubs

Ciliated biobots (CiliaBots) are engineered tissues capable of self-actuated propulsion via exterior motile cilia. While correlations have been observed between CiliaBot motility and morphology, direct control of morphological features to deliver desired motility outcomes remains unexplored. Here, we describe the engineering of aggregated CiliaBots (AggreBots) to augment control over CiliaBot structural parameters and, consequently, motility patterns through guided, modular aggregation of human airway epithelial spheroids [referred to as CiliaBot building blocks (CBBs)]. Multi-CBB aggregation generated rod-, triangle-, and diamond-shaped AggreBots, altering tissue geometry without sacrificing surface cilia density or inter-CBB boundary fidelity. The further introduction of

Microstructure Densification In Cement Pastes Enabled By Novel Graphene Types, Sahil Surehali, Taihao Han, Ranjith Divigalpitiya, Aditya Kumar, Narayanan Neithalath

Materials Science and Engineering Faculty Research & Creative Works

The primary barriers hindering graphene's widespread adoption as a performance-enhancing additive in cement-based systems have traditionally been its prohibitive cost and the sustainability concerns associated with conventional manufacturing processes. However, these impediments have recently been mitigated by advancements in detonation synthesis techniques, enabling scalable, cost-effective, and environmentally favorable production of novel graphene types—specifically fractal graphene (FG) and reactive graphene (RG). This paper explores the influence of ultra-low dosages of FG and RG (≤ 0.04 % by mass of cement, which results in ∼20 % increase in compressive strengths) on the pore-structure features of cement pastes. Compared to the control paste, …

Warpage-Resistant, Under-Extrusion-Free, High-Surface-Quality Additive Manufacturing Process For Polyethylene-Based Composite Radiation Shielding Material, Duo Xu, Volodymyr Korolovych, You Lyu, Jacqueline Aslarus, Domingo R. Flores-Hernandez, Simo Pajovic, William T. Heller, Lembit Sihver, Svetlana V. Boriskina

Informatics and Engineering Systems Faculty Publications

Polyethylene (PE) is one of the best shielding materials for primary space radiation due to its high hydrogen content. For effective secondary neutron shielding, boron-rich fillers are incorporated to enhance performance. The semicrystalline nature and high thermal expansion coefficient of PE impede its adoption for in situ additive manufacture in space via the fused deposition modeling (FDM) 3D printing. We developed an optimized PE blend to mitigate the effects of under-extrusion and warpage. Guided by studies on extrusion and warpage, we developed an optimal set of printing parameters for the proposed PE blend. The optimum PE blend─both in its pure …

Board Of Trustees Meeting Minutes 2025-09-26, Bowling Green State University

Board of Trustees Meeting Minutes

The official meeting minutes of Bowling Green State University's Board of Trustees.

Polymorphism Crystal Structure Prediction With Adaptive Space Group Diversity Control, Sadman Saadeed Omee, Lai Wei, Jianjun Hu

Faculty Publications

Crystalline materials can form different structural arrangements (i.e., polymorphs) with the same chemical composition, exhibiting distinct physical properties depending on how they are synthesized or the conditions under which they operate. For example, carbon can exist as graphite (soft, conductive) or diamond (hard, insulating). Computational methods that can predict these polymorphs are vital in materials science, which help understand stability relationships, guide synthesis efforts, and discover new materials with desired properties without extensive trial-and-error experimentation. However, effective crystal structure prediction (CSP) algorithms for inorganic polymorph structures remain limited. ParetoCSP2 is proposed, a multi-objective genetic algorithm for polymorphism CSP that incorporates …

The Emerging Role Of Osteopathic Manipulative Medicine In Enhancing Quality Of Life For Palliative And End-Of-Life Patients: A Narrative Review, Ambrose Loc T. Ngo, Linda Nguyen, Cynthia Shahbandeh, Jared W. Nichols

Student Publications

Palliative and end-of-life care aim to minimize suffering and optimize the quality of life for individuals nearing the end of their lives. Osteopathic manipulative medicine (OMM) represents a potentially valuable nonpharmacological approach within this integrative care framework. Emerging evidence from clinical observations, small-scale studies, and foundational osteopathic principles suggests that OMM may help support patient comfort, alleviate certain symptoms, and contribute to dignity in care. Techniques such as myofascial release, cranial manipulation, and lymphatic drainage have been reported to improve comfort and emotional well-being; however, these findings are based primarily on limited and heterogeneous studies. This narrative review synthesizes current …

Pendant Micro-Droplet Evaporation Fabricates Fiber-Optic Mof Gas Sensor In Seconds, Abhishek Prakash Hungund, Bohong Zhang, Narasimman Subramaniyam, Thomas Spudich, Ryan O'Malley, Farhan Mumtaz, Rex E. Gerald, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

The development of photonic-based gas sensors using metal–organic frameworks (MOFs) and other microporous solids is often a multistep, complex process, typically involving MOF synthesis, purification, and attachment of microcrystals to an optical fiber end face. This study introduces a one-step method that integrates MOF synthesis and sensor head fabrication directly onto the fiber end face, forming an extrinsic Fabry–Perot interferometer (EFPI) with a thin film of MOF microcrystals. The resulting film, only 3–10-μm-thick, enhances sensor response by enabling rapid gas detection within seconds. Utilizing a pendant micro-droplet evaporation technique, this method forms a microporous MOF layer in situ, allowing unreacted …

Magnesium Sulfate Attack Of Alite Paste And Mitigation By Surface Carbonation: Monitoring And Comparison Using Novel Portable Fiber-Optic Raman Probe, Bohong Zhang, Gao Deng, Hongyan Ma, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

Sulfate attack on cement matrix is still a "confused world" especially when magnesium sulfate (MgSO₄) is the sulfate source. Accurate assessment of sulfate attack is essential for evaluating the structural integrity and durability of concrete in relevant environments. This study presents a portable fiber-optic Raman probe approach with 125 μm spatial resolution, designed for depth-resolved sulfate ingress monitoring in tricalcium silicate (C₃S, Alite) pastes. The probe is also used to evaluate the effectiveness of surface carbonation in mitigating sulfate attack. The results demonstrate a strong correlation between sulfate penetration depth and Raman spectral intensity ratios of sulfate-related vibrational …

Improvement Of Lithium-Metal Electrode All-Solid-State Batteries Performance By Shot Peening And Magnetron Sputtering, Atsuro Okumura, Manabu Kodama

15th International Conference on Shot Peening

To enable fast charging in lithium-metal anode all-solid-state batteries, suppressing lithium dendrite formation at the solid electrolyte (SE) interface is critical. Increasing fracture toughness via shot peening (SP) and improving interfacial contact with Au sputtering can inhibit dendrite growth. However, conventional sputtering may reduce toughness due to localized thermal damage. This study investigated magnetron sputtering as a low-damage, plasma-based Au deposition method. SEs with and without SP were fabricated and coated via normal and magnetron sputtering. Critical current density (CCD) and fracture toughness were evaluated. Without SP, CCD improvement was limited regardless of sputtering method due to poor bonding. With …

Hydrogen Embrittlement In Shot-Peened Steel, Jia-Huei Tien, David R. Johnson, David Bahr

15th International Conference on Shot Peening

This work investigates the role of shot peening on hydrogen embrittlement resistance in quenched and tempered 1070 steel. Thermal desorption spectroscopy results revealed that shot-peened specimens contained nearly twice the hydrogen (H) content of unpeened samples when charged under the same electrochemical conditions, suggesting the introduction of additional trapping sites occur during peening. The mechanism underlying this behavior can be associated with increased dislocation density and is more consistent with the HELP mechanism. Residual stress measurements show a significant relaxation of compressive stresses in shot-peened specimen after H charging, indicating H enhanced dislocation rearrangement. Both unpeened and peened specimens exhibited …

Investigation Of Topography Changes Of Blasted Surfaces: An Experimental Perspective Using Fiducial Markers, Stefanie Stoeckel, Sophie Groeger

15th International Conference on Shot Peening

Abrasive blasting is a process that intentionally modifies surface topography to meet specific functional requirements. The blast media is accelerated and interacts directly with the surface through impact. It is evident that the number of impacts and the overlap increase with time. This study aims to investigate these alterations to surface topography through repeated examinations of the same location. A methodology has been developed that employs the use of fiducial markers, which are protected during blasting by a custom 3D-printed cover. This method was used to observe changes in the topography of smooth and rough initial surfaces that had been …

Anisotropic Residual Stress Measurements In Additively Manufactured 316 Stainless Steel Parts, Rajeshree Varma, Donovan Stumpf, Paul R. Mort

15th International Conference on Shot Peening

Additive manufacturing (AM) using laser powder bed fusion (L-PBF) is increasingly used to produce complex parts for industries like aerospace and medical devices. The intrinsic characteristics of AM – layer-wise deposition and rapid thermal cycling – generate significant, anisotropic, residual stresses that can compromise part quality and performance. Recent studies highlight how these stresses are strongly influenced by process parameters and build orientation. X-ray diffraction (XRD) techniques, including sin²ψ and advanced two-dimensional approaches, have become the preferred methods for non-destructive, directionally resolved measurement of residual stress in AM metals. This review surveys advancements in XRD residual stress methods with a …

From Strain To Stress: Stress Map Testing Of Almen Strips, Donovan Stumpf, Rajeshree Varma, Paul R. Mort

15th International Conference on Shot Peening

Almen strips have long been used to evaluate shot peening intensity, with arc height serving as a proxy for compressive residual stress. Stress mapping tests (SMT) in this work involve the controlled flattening of an Almen test strip onto a spatial pressure sensor, acting as an inferential measurement for the net bending moment caused by the relaxation of the peened strip. This work explores how stress mapping tests add insight into the stress state of Almen strips, potentially offering a fast and practical alternative to residual stress depth profiling. SMT data analysis provides a framework for relating Almen gauge height …

A Novel Scaffold-Based Model For Stage Ii Pressure Injury Simulation: Protocol Development And Future Directions In Tissue Engineering, Skyler B. Wrubleski

Undergraduate Research and Scholarship Symposium

This study developed a 3D tissue-engineered scaffold to mimic human sacral skin for modeling pressure injuries. The scaffold consisted of a composite hydrogel of sodium alginate, gelatin, and tannic acid, crosslinked with calcium chloride. Swelling tests showed moderate hydration capacity, while wound mimic formation using a custom 3D-printed apparatus produced consistent morphology and dimensions comparable to human dermal tissue. The scaffold maintained structural integrity under prolonged compressive forces, demonstrating viability for pressure injury studies. Future work will incorporate a bilayer model with keratinocytes and fibroblasts and introduce elastin to enhance elasticity and mechanical properties. This approach aims to improve in …

Fourier Analyses Of Optical Profilometry As An Inferential Measurement For Impact Coverage., Langdon Feltner, Paul Mort

15th International Conference on Shot Peening

A critical consideration in peening process design is achieving sufficient impact coverage. Conventional methods for assessing coverage rely on manual inspection, which is time-consuming and poorly suited for automated control. In this work, we investigate the use of frequency-domain analysis to quantify surface modification in peened samples using optical profilometry (OP) data. Three-dimensional surface maps of Almen strips were acquired using a high-resolution OP system and analyzed via fast Fourier transform (FFT) to compute spatial power spectral densities (PSDs). PSD maps and radially averaged profiles reveal consistent amplification of harmonic components similar to the nominal particle size, with increasing intensity …

Artificial Intelligence, Age, And Dynamic Ticket Pricing: A Mixed-Methods Study In Professional Sports, Joshua Greer, Nicholas Zoroya

Global Sport Business Journal

Abstract

This study investigates how age moderates fan perceptions of artificial intelligence (AI) and dynamic ticket pricing (DTP) in professional sports. Using a mixed-method design, data was collected from a self-administered online survey (N = 57) and triangulated with secondary sources, including industry reports and academic literature. Survey participants were divided into four generational cohorts and responses were analyzed across three constructs: perceived fairness, accessibility, and willingness to pay. A one-way ANOVA revealed a statistically significant difference in willingness to pay across age groups, F(3, 53) = 3.41, p = .015, with the most pronounced disparity between the youngest and …