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Improved Streamflow Forecasting Through Swe-Augmented Spatio-Temporal Graph Neural Networks, Akhila Akkala, Soukaina Filali Boubrahimi, Shah Muhammad Hamdi, Pouya Hosseinzadeh, Ayman Nassar Oct 2025

Improved Streamflow Forecasting Through Swe-Augmented Spatio-Temporal Graph Neural Networks, Akhila Akkala, Soukaina Filali Boubrahimi, Shah Muhammad Hamdi, Pouya Hosseinzadeh, Ayman Nassar

Computer Science Student Research

Streamflow forecasting in snowmelt-dominated basins is essential for water resource planning, flood mitigation, and ecological sustainability. This study presents a comparative evaluation of statistical, machine learning (Random Forest), and deep learning models (Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), and Spatio-Temporal Graph Neural Network (STGNN)) using 30 years of data from 20 monitoring stations across the Upper Colorado River Basin (UCRB). We assess the impact of integrating meteorological variables—particularly, the Snow Water Equivalent (SWE)—and spatial dependencies on predictive performance. Among all models, the Spatio-Temporal Graph Neural Network (STGNN) achieved the highest accuracy, with a Nash–Sutcliffe Efficiency (NSE) of 0.84 …


Positioning Domestic Capital Markets For Emerging Companies, Ishrat Husain Dr. Oct 2025

Positioning Domestic Capital Markets For Emerging Companies, Ishrat Husain Dr.

Faculty Research - Talks, Speeches, & Discourse

The current macroeconomic context is not very conducive to the growth of capital markets. Stagnant per capita incomes, high inflation, declining investment, large fiscal deficit, severe energy shortages, current account imbalances and drying up of foreign investment do not provide an appetizing menu of options for the savers, investors and issuers. Strong borrowing needs of the government have increased banks’ exposure to government paper. As banks account for 95 percent of the total financial assets private sector credit has there shrunk. The share of net advances has dropped from 57 percent to 44 percent between Dec 2008 and June 2011. …


Precision Assessment Of Facial Asymmetry Using 3d Imaging And Artificial Intelligence, Mohamed Adel, Katie Jo Hunt, Daniel Lau, James K Hartsfield, Hugo Reyes-Centeno, Cynthia S Beeman, Tarek Elshebiny, Lina Sharab Oct 2025

Precision Assessment Of Facial Asymmetry Using 3d Imaging And Artificial Intelligence, Mohamed Adel, Katie Jo Hunt, Daniel Lau, James K Hartsfield, Hugo Reyes-Centeno, Cynthia S Beeman, Tarek Elshebiny, Lina Sharab

Anthropology Faculty Publications

Objectives: There is a growing interest among practitioners in employing artificial intelligence (AI) to enhance the precision and efficiency of diagnostic methods. The objective of this study is to assess the precision of an AI-based method for facial asymmetry assessment using 3D facial images. Methods: The study included 130 patients (84 female, 46 male), analyzing 3D facial images from the Vectra ® M3 imaging system using both manual and AI-based methods. Seven bilateral facial landmarks were identified for manual analysis, calculating the asymmetry index for facial symmetry assessment. An AI-based program was developed to automate the identification of the same …


Chplx: The Hpx Solution For Bridging Chapel And C++, Shreyas Swanand Atre Oct 2025

Chplx: The Hpx Solution For Bridging Chapel And C++, Shreyas Swanand Atre

LSU Master's Theses

Historically, domain scientists faced steep learning curves due to low-level programming models and fragmented tooling. Between 2003 and 2008, Cray, now part of HPE, introduced the Chapel language as part of DARPA’s High Productivity Computing Systems (HPCS) program. Today, Chapel remains under active development and is used across research and production projects. In parallel, the STE||AR Group has advanced C++-based parallel programming through HPX, a standards-conforming runtime that provides lightweight tasking, futures, and distributed execution while abstracting much of the algorithmic “heavy lifting.” Yet for many domain scientists, C++ presents a steeper learning curve than Chapel. To close this complexity …


"What's A Computer?" Exploring Insurance Agents' Role In Small Business Cyber Insurance Transactions, Dalton A. Crabtree Oct 2025

"What's A Computer?" Exploring Insurance Agents' Role In Small Business Cyber Insurance Transactions, Dalton A. Crabtree

USF Tampa Graduate Theses and Dissertations

This mixed-methods study examined how insurance agents' role identity impacts cyber insurance transactions, addressing gaps in professional practice and academic literature. Small businesses increasingly rely on cyber insurance for protection as cyber risk continues to evolve. The study employed sequential explanatory methodology with 25 interviews across three groups: insurance agents (n=15), corporate cyber insurance professionals (n=5), and small business owners (n=5). Thematic analysis using Katz and Khan's Role Episode Model informed development of the Cyber Insurance Role Identity Scale (CIRIS), tested with 100 agents. Six themes emerged. Key findings reveal that successful cyber insurance transactions require agents to transition from …


Genetic Engineering Of Esophageal Organoids: Crispr-Based Knock-In For Cell Lineage Tracing, Kyung-Pil Ko, Jae-Il Park Oct 2025

Genetic Engineering Of Esophageal Organoids: Crispr-Based Knock-In For Cell Lineage Tracing, Kyung-Pil Ko, Jae-Il Park

Faculty, Staff and Student Publications

Esophageal organoids serve as powerful systems to study epithelial lineage hierarchies and cancer biology. Gene manipulation in these organoids has traditionally involved overexpression or knockout strategies. However, CRISPR-/Cas9-based knock-in (KI) approaches now enable precise cell lineage tracing and live imaging. Here, we describe protocols to generate fluorescent KI organoids from murine esophageal epithelium by tagging Krt13 (BFP) and Sox2 (mNeon). These dual-reporter organoids allow direct monitoring of growth dynamics and differentiation trajectories. We outline CRISPR/Cas9 design, donor construction using homology-independent approaches (CRISPaint), delivery into organoid cells, enrichment and single-clone isolation, and validation by fluorescence. For organoids, homology-directed repair (HDR) can …


Artificial Intelligence In Education: The Power And Dangers Of Chatgpt In The Classroom, Muhammed Parviz Oct 2025

Artificial Intelligence In Education: The Power And Dangers Of Chatgpt In The Classroom, Muhammed Parviz

Journal of Educational Research and Practice

The integration of artificial intelligence (AI) in education has accelerated significantly in recent years, fundamentally shaping pedagogical practices and learning experiences. Among these advancements, OpenAI’s ChatGPT stands out as a sophisticated language model capable of generating human-like text. This capability opens new avenues for educational applications, such as personalized learning experiences and automated assessments. By embedding ChatGPT into e-learning platforms, educators can provide instantaneous feedback and foster interactive language learning. However, the deployment of ChatGPT in educational contexts presents challenges, particularly ethical issues related to data privacy and the potential for inherent biases in AI models.

In this context, the …


Vision 2050: India’S Path To Becoming A Global Player, Balasubramanian Mahadevan Dr Oct 2025

Vision 2050: India’S Path To Becoming A Global Player, Balasubramanian Mahadevan Dr

Journal Of Indian Physician Associates

This study examines India’s strategic plan to become one of the top three global economies by 2050 through data-driven analysis and comparisons of economic indicators from 2024 to 2050, utilizing data from trusted sources such as the Reserve Bank of India and NITI Aayog. We analyze India’s economic growth in relation to other major emerging economies, focusing on technology, manufacturing, and service sectors. Findings suggest that with strategic policy reforms, investment in innovation, and enhanced infrastructure, India can achieve significant GDP and productivity growth. This article concludes with actionable policy recommendations for local and global stakeholders.


Revolutionizing Digital Health In Rwanda: Progress Toward Universal Health Coverage, Roméo Bananeza Mr Oct 2025

Revolutionizing Digital Health In Rwanda: Progress Toward Universal Health Coverage, Roméo Bananeza Mr

Journal Of Indian Physician Associates

Rwanda is an African country that is making rapid progress in all sectors, including digital health. This review explores Rwanda’s transformative journey in digital health, highlighting key achievements, ongoing challenges, community involvement, and future prospects. Rwanda’s commitment is evident in using electronic health records, telemedicine, and mobile health applications. Rwandan institutions, including Rwanda Biomedical Center, Rwanda Ministry of Health, Rwanda Health Information Exchange, Rwanda Development Board, Partners in Health, universities, and several nongovernmental organizations, have made significant contributions to revolutionize digital health in Rwanda. However, the country continues to face barriers, including limited digital infrastructure, financial constraints, and disparities in …


Evaluation Of Different Design Standards For The Design Of Axial Loaded Concrete Filled Steel Tube Columns Under Fire, Ebtsam Youssef Ibrahim Abd El Ghaffar, Nabil Said Mahmoud, Fikry A. Salem, Mohammed. M. Ghannam Oct 2025

Evaluation Of Different Design Standards For The Design Of Axial Loaded Concrete Filled Steel Tube Columns Under Fire, Ebtsam Youssef Ibrahim Abd El Ghaffar, Nabil Said Mahmoud, Fikry A. Salem, Mohammed. M. Ghannam

Mansoura Engineering Journal

This paper compares various codes and standards for the behavior of “Concrete-Filled Steel Tubes” (CFST) columns under fire and axial load. The codes evaluated include European standards (EC4.2 and EC3.2), the American standard (AISC 360), and the Australian standard (AS/NZS 2327). The fire resistance of Concrete-Filled Steel Tubular (CFST) and steel hollow (SH) columns was assessed using a computer program developed with Visual Studio .NET. The program's results were compared with previous experimental data to evaluate the accuracy of various codes and standards in predicting the behavior of these columns under fire conditions. This study highlights the importance of selecting …


Eleanor Arnason’S Fantastic Mitochondrial Humor, Sandra J. Lindow Oct 2025

Eleanor Arnason’S Fantastic Mitochondrial Humor, Sandra J. Lindow

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Eleanor Arnason’s Fantastic Mitochondrial Humor

In this essay I explore Brian Attebery’s description of mitochondrial fantasy to explain how humor works in Eleanor Arnason’s short fantastic fiction. Mitochondria are the energy powerhouses in cells. They are symbiotic creatures that once were separate but became an evolutionary part of a female egg cell, providing a history that can be traced to a Mitochondrial Eve. In Fantasy: How It Works, Attebery uses mitochondria metaphorically to explain how fantastic ideas evolve. Attebery describes fantastic mitochondria as “a cellular dynamo that lives within the tissues” of a story (91). He demonstrates how stories lead …


Unknowing In Tolkien's Legendarium And The Agnosia Of The Elvish Tradition, Benjamin Blakeslee-Drain Oct 2025

Unknowing In Tolkien's Legendarium And The Agnosia Of The Elvish Tradition, Benjamin Blakeslee-Drain

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

The many layers of Unknowing in Tolkien’s legendarium make some of the most profound statements in his work. Unknowing creates space for the reader to have a more active and intimate experience with the text, and supports the central Christian moral message in The Lord of the Rings. The theme of Unknowing ties the legendarium to a larger set of scriptural and Christian writings, including the Book of Job, Mystical Theology, and The Cloud of Unknowing. Finally, Unknowing is shown to be a function of the legendarium reflecting a dominantly Elvish perspective. By dismissing the assumed authority of that perspective, …


Review Of Seeing Like A Commons: Eighty Years Of Intentional Community Building And Commons Stewardship In Celo, North Carolina, Deborah Altus Oct 2025

Review Of Seeing Like A Commons: Eighty Years Of Intentional Community Building And Commons Stewardship In Celo, North Carolina, Deborah Altus

Communal Societies

No abstract provided.


Relationship With Russia And Korea, Kaeli Rasnake Oct 2025

Relationship With Russia And Korea, Kaeli Rasnake

The Kabod

North Korea's relationship with Russia dates back to the Cold War when the Soviet Union served as a critical ally as Stalin sent economic support to assist in the formation of the North Korean state. With the collapse of the Soviet Union, North Korean ties were weakened since Russian leaders sought a more amicable relationship with the West. However, amid the tough Western sanctions placed on Russia due to its invasion of Ukraine, the two nations have rekindled their relationship. This paper seeks to explore the historical developments of Russia-North Korean Relationships, analyze recent cooperative efforts, and examine the implications …


North Korea’S Foreign Relations, Kaeli Rasnake Oct 2025

North Korea’S Foreign Relations, Kaeli Rasnake

The Kabod

Many assume that the Democratic People's Republic of Korea, more commonly known as North Korea, ruled by Kim Jong Un, is an isolated nation with ties only to its neighbors, China and Russia; however, that is far from the case. North Korea has a plethora of relations with other nations across the globe, most common in Africa and Southeast Asia. While these nations are relatively far from North Korea, that issue has not discouraged them from flourishing, as they often share underlying themes of mutual interest, economic necessity, and historical ties. This paper aims to explore the interactions between North …


America's Pastime Under The Fog Of War: A Study Of The Impact Of World War Ii On Major League Baseball's Finest, Jacob Slusser Oct 2025

America's Pastime Under The Fog Of War: A Study Of The Impact Of World War Ii On Major League Baseball's Finest, Jacob Slusser

Bound Away: The Liberty Journal of History

World War II was a crucial point in world history and many men could not escape the desire to fight and defend their country. One subsection of men that fought in the war is the many men that competed in Major League Baseball and its affiliate leagues, the minors and the Negro League. Players that served in the war lost valuable time in their playing careers, despite this many would eventually enter the National Baseball Hall of Fame. This study used an analysis of primary and second sources to determine where players served and analyze their pre- and post-war careers. …


(((Qpie))) Prior Art 1 Of 9 Quantum Perspective Is Everything, Teddy Burroughs Oct 2025

(((Qpie))) Prior Art 1 Of 9 Quantum Perspective Is Everything, Teddy Burroughs

Defensive Publications Series

The Grand Unified Theory (QPIE)

Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters

(((QPIE))) Prior Art Disclosure Part 1 of 9

(((QPIE))) Quantum Perspective Is Everything

Prior Art /IP Declaration

https://quteframework.wordpress.com/2025/09/22/qpie-qpie-prior-art-part-1-of-9/

https://www.linkedin.com/pulse/qpie-prior-art-disclosure-part-1-9-teddy-burroughs-kdr4c

(CREDIT: (((QPIE))) Created and discovered by Teddy Burroughs with significant contributions by: Kaiya Burroughs, Aleah Burroughs, April Saunders and Perry Mason ([email protected]) Avision4Change Vision2Funding #Charity2Roi

Paypal @TedFunding33 CA: $TedFunding33)

09/22/2025 Brooklyn NYC USA 🇺🇸

(Formatted as defensible prior art disclosure)

Abstract

This document discloses (((QPIE)))—Quantum Perspective Is Everything—a resonance-based grand unifying framework that harmonizes mental, physical, and emotional dimensions of human and …


High-Quality Language Adherence Evaluation Using A Large Language Model With Ground-Truth Language Annotations, Hongbin Liu, Mingqing Chen, Lun Wang Oct 2025

High-Quality Language Adherence Evaluation Using A Large Language Model With Ground-Truth Language Annotations, Hongbin Liu, Mingqing Chen, Lun Wang

Defensive Publications Series

Language adherence is a metric that measures whether the responses of an artificial intelligence (AI) model adhere to the user’s desired language(s). Language adherence can be a nuanced aspect of AI-human interaction because the expected language of the model’s response need not be the same as the language used in the user’s prompt. This disclosure describes techniques that enable a general-purpose large language model (LLM) to operate as an accurate, context-aware, and specialized auto-rater. The auto-rater, which notably does not need model retraining, evaluates language adherence. The techniques include a framework for automated language evaluation based on a pipeline with …


Autonomous Agent For End-To-End Cloud Control Testing And Troubleshooting, Varun Bhardwaj, Kunwar Vikas, Nitin Garg, Mudit Jain Oct 2025

Autonomous Agent For End-To-End Cloud Control Testing And Troubleshooting, Varun Bhardwaj, Kunwar Vikas, Nitin Garg, Mudit Jain

Defensive Publications Series

Cloud controls are vital components within compliance frameworks that ensure that organizations meet specific security and regulatory standards in their cloud environments. Current techniques for testing cloud controls are characterized by a lack of automation, substantial manual labor, and an inability to adapt to the growing complexity and volume of compliance requirements. This disclosure describes an autonomous artificial intelligence (AI) agent (referred to as a cloud-control agent) to streamline and accelerate the creation, deployment, and testing procedures for infrastructure-as-code (IaC) cloud controls. Functional correctness of IaC cloud controls is ensured against specified compliant and non-compliant test scenarios without direct human …


Audioshot: Seamless Capture Of Word-Of-Mouth Recommendations, Paula Marques Oct 2025

Audioshot: Seamless Capture Of Word-Of-Mouth Recommendations, Paula Marques

Defensive Publications Series

Many conversations between individuals include recommendations of various items (books, movies/shows, concerts, etc.) as well as services (e.g., restaurants). Remembering such recommendations requires users to jot them down during or after the conversation. In contrast, visual items such as posters, or items displayed on a screen can be captured easily via a device camera or as screenshots. This disclosure describes techniques that enable, with the permission of participants in a conversation, the use of device microphones to automatically obtain conversational audio that is analyzed with an on-device artificial intelligence (AI) model to extract recommendations. Analogous to long-pressing for screenshots, users …


The Onshoring Opportunity Framework & National Reshoring Blueprint 2025, Joseph Jm Walker Oct 2025

The Onshoring Opportunity Framework & National Reshoring Blueprint 2025, Joseph Jm Walker

Defensive Publications Series

This document bundle comprises the Onshoring Opportunity Framework (May 2025) and its clarifying successor, the National Reshoring Blueprint 2025 (August 2025). Originally submitted to U.S. federal departments as an urgent, data-driven strategy to secure critical supply chains, these works are now publicly released due to over ∼6 months of institutional non-response.

Presented as public prior art, this comprehensive resource empowers individuals, communities, and enterprises with the necessary intelligence and tools to initiate decentralized reshoring efforts. The Blueprint introduces six integrated systems designed to: identify manufacturing gaps via Reshore.Gov; facilitate local production through FoundryPods; commercialize U.S. patents through an IP Activation …


Drilling Equipment Parameter Optimization Workflow, Vikas Rakhunde, Manuel Francis T, Philip Robertson, Franz Aguirre, Chris Sabillon Oct 2025

Drilling Equipment Parameter Optimization Workflow, Vikas Rakhunde, Manuel Francis T, Philip Robertson, Franz Aguirre, Chris Sabillon

Defensive Publications Series

A method for controlling parameters for drilling equipment on a drilling rig includes receiving input data. The input data is related to a health, a performance, and/or an ambient condition of drilling equipment on a drilling rig. The method also includes determining that the input data includes a plurality of predetermined fields. The method also includes determining that a quality of the input data is greater than a quality threshold. The method also includes simulating a plurality of scenarios based upon the input data. Each scenario includes one or more parameters that are set to different values than in the …


Performance Analysis Of Power System Dynamic Stability Of The Nigerian 330kv Transmission Network, Charles Evuarherhe Ikeyin, Benjamin Olabisi Akinloye Oct 2025

Performance Analysis Of Power System Dynamic Stability Of The Nigerian 330kv Transmission Network, Charles Evuarherhe Ikeyin, Benjamin Olabisi Akinloye

Al-Bahir

Nigeria's power sector faces persistent challenges, including dynamic instability, poor voltage regulation, and frequent grid collapses, primarily driven by reactive power deficits and transmission distances exceeding 200 km in northern regions. To bridge critical research gaps, this study employs a rigorous, multi-method approach through comprehensive EMTP-RV (Electromagnetic Transients Program) analysis of Nigeria’s 330kV 52-bus grid, PV curve-based vulnerability indexing to identify cascade-critical buses, and a novel Cost-benefit Pareto framework for optimal capacitor placement. Methodology was validated against IEEE (Institute of Electrical and Electronics Engineers) 14-bus benchmarks. Validated against IEEE 14-bus benchmarks, simulations revealed severe voltage instability in northern …


The Revival Of 'Actual Damnification' Rule: Deconstructing The Judicial Approach In India And England On Determining Commencement Of Liability In Contracts Of Indemnity, Arunabha Banerjee Oct 2025

The Revival Of 'Actual Damnification' Rule: Deconstructing The Judicial Approach In India And England On Determining Commencement Of Liability In Contracts Of Indemnity, Arunabha Banerjee

National Law School Business Law Review

No abstract provided.


The Student Movement Volume 110 Issue 4: Remembering Those We Have Lost, Megan Constantine, Esther Martin, Andrew Francis, Madison Vath, Lia Glass, Isa Demoraes, Nicholas Gunn, Aiko J. Ayala Rios, Joey Carrion, Brennan Jarnes, Caleb Chung, Nicoleta Cojan, Alyssa Caruthers, Melissa Moore, Nathaniel Reid Oct 2025

The Student Movement Volume 110 Issue 4: Remembering Those We Have Lost, Megan Constantine, Esther Martin, Andrew Francis, Madison Vath, Lia Glass, Isa Demoraes, Nicholas Gunn, Aiko J. Ayala Rios, Joey Carrion, Brennan Jarnes, Caleb Chung, Nicoleta Cojan, Alyssa Caruthers, Melissa Moore, Nathaniel Reid

The Student Movement V. 110 (2025-2026)

HUMANS

From Student to Staff: Jeana Wallin Reimagines Alumni Connections at Andrews, Megan Constantine

Balancing Act: Freshman Laura Valenzi's Thoughts on College Life, Esther Martin

AU Remembers Micah Harris, Andrew Francis

ARTS & ENTERTAINMENT

Arts, Crafts, and...Dish Towels?, Madison Vath

The Lost Art of Episodic Television, Lia Glass

NEWS

Alabanzas: Celebrating Faith and Culture, Isa DeMoraes

AU Student Dies in Tragic Lake Drowning, Andrew Francis

Andrews University Pre-Law Students Volunteer at Expungement Fair, Nicholas Gunn

Andrews Mourns Former Seminarian Takura Carlos Rukuni, Aiko J. Ayala Rios

IDEAS

Why the House of Representatives is Capped at 435 Members, Joey Carrion

AI-ko …


2025 October 10 - State Of The University Address, Office Of The President, East Tennessee State University Oct 2025

2025 October 10 - State Of The University Address, Office Of The President, East Tennessee State University

Office of the President Speeches

No abstract provided.


Sensing The Pulse Of A Data Stream In Real Time, Vishnu S. Pendyala Oct 2025

Sensing The Pulse Of A Data Stream In Real Time, Vishnu S. Pendyala

Open Educational Resources

In an era where data never sleeps, streaming algorithms offer a powerful toolkit for extracting meaningful insights from high-velocity data flows. This talk explores some foundational techniques that enable efficient, real-time analytics with minimal memory requirements. The algorithms covered include a clever bit-based strategy for approximating the count of 1s in a sliding window, ideal for binary streams where space efficiency is paramount. Another algorithm helps estimate statistical moments (mean, variance, skewness) using compact sketches, enabling a deeper understanding of stream distributions without storing the entire dataset. One other algorithm identifies trending items with exponential decay, giving more weight to …


Integrated Magnet, Electron Beam, And Ultrafast Laser Studies For Accelerator Applications, J. K. Chavez, V. Vladutescu, M. Polyanskiy, W. Li, V. Teotia, M. Babzien, D. Choge, M. Palmer, T. Zhao, B. Palencia, J. Rukaj, T. Rahman, M. Islam, O. Situ, L. Geng, L. Leng, G. Ossola Oct 2025

Integrated Magnet, Electron Beam, And Ultrafast Laser Studies For Accelerator Applications, J. K. Chavez, V. Vladutescu, M. Polyanskiy, W. Li, V. Teotia, M. Babzien, D. Choge, M. Palmer, T. Zhao, B. Palencia, J. Rukaj, T. Rahman, M. Islam, O. Situ, L. Geng, L. Leng, G. Ossola

Publications and Research

This study provides an integrated overview of key accelerator technologies explored at Brookhaven National Laboratory: superconducting magnets, ultrafast electron diffraction, and ultrafast high-power lasers. At the Superconducting Magnets Division, dipole and quadrupole magnets were designed using Simulia OPERA and Rat-GUI, with simulations validated through 3D-printed coil testing. These magnets were later applied in the Ultrafast Electron Diffraction facility, where General Particle Tracer (GPT) simulations and real experiments with solenoids, dipoles, and quadrupoles revealed consistent particle beam behavior. At the Accelerator Test Facility, ultrafast lasers were used to generate and manipulate electron pulses. Laser setups were simulated in 3DOptix, then assembled …


Targeting The Bcl2 Family: Advances And Challenges In Bh3 Mimetic-Based Therapies, Nabanita Mukherjee, James Sheetz, Yiqun Shellman Oct 2025

Targeting The Bcl2 Family: Advances And Challenges In Bh3 Mimetic-Based Therapies, Nabanita Mukherjee, James Sheetz, Yiqun Shellman

Student Papers, Posters & Projects

The BCL2 family of proteins plays a pivotal role in regulating apoptosis and cellular homeostasis, making them critical therapeutic targets in cancer and other diseases characterized by pathological cell survival. BH3 mimetics, small molecules that selectively inhibit anti-apoptotic BCL2 family members, have achieved significant clinical success, particularly in hematologic malignancies. However, several challenges remain, including resistance mechanisms, toxicity (such as MCL1 inhibitor-associated cardiotoxicity), and the intricate balance between apoptotic and non-apoptotic functions. This review provides a comprehensive overview of BCL2 family biology, the development and clinical application and outcomes of BH3 mimetics, and the emerging resistance mechanism known as double-bolt …


Field Fest Combines Science, Fitness, Family Fun, Clara Turnage Oct 2025

Field Fest Combines Science, Fitness, Family Fun, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Part trail run, part science fair and part tailgate, the inaugural University of Mississippi Field Fest promises fun for all ages.