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Nih Funding Ud Engineers' Mission To Better Detect Pediatric Lung Nodules, University Of Dayton

News Releases

University of Dayton researchers are helping Cincinnati Children's Hospital Medical Center by developing artificial intelligence to better detect lung nodules in CT scans of children. To date, no pediatric-specific systems have been developed or tested.

Correction: Magnetized Chitosan Hydrogel And Silk Fibroin, Reinforced With Pva: A Novel Nanobiocomposite For Biomedical And Hyperthermia Applications, Reza Eivazzadeh-Keihan, Zeinab Pajoum, Hooman Aghamirza Moghim Aliabadi, Adibeh Mohammadi, Amir Kashtiaray, Milad Salimi Bani, Banafshe Pishva, Ali Maleki, Majid M. Heravi, Mohammad Mahdavi, Elaheh Ziaei Ziabari

Rothman Institute Papers

The authors regret that they omitted a citation to ref. 1 in their original article. This citation should be included in Section 3 (Result and discussion) before Section 3.1 (FT-IR spectroscopy and XRD analysis). The authors wish to add the following paragraphs to the discussion section of the original article, to be read in Section 3 (Result and discussion) before Section 3.1 (FT-IR spectroscopy and XRD analysis), after the sentence “.Finally, hyperthermia application was appraised and all results were evaluated.” in order to clarify the novelty of this work over ref. 1. In the previous work, we developed a multifunctional …

Chitosan Nanofibrous Dressing Increased Angiogenesis And Anti-Inflammatory Response In An Acute Wound Model In Rats: A Comparative Study, Yury Salkovskiy, Mahboubeh Ghanbari, Carlos P Jara, Sara Cartwright, Pinaki Mondal, Colman Freel, Sayed Ahmadreza Razian, Jason Mactaggart, Mark A. Carlson

Journal Articles

Purpose

Chitosan-based materials are promising for wound healing because of their antibacterial efficacy, biocompatibility, and biodegradability, though their healing mechanisms remain unclear. This study explores the cellular and molecular mechanisms of wound healing with chitosan nanofibrous dressings.

Methods

Thirty-nine Sprague Dawley rats were divided into three groups based on the type of dressings administered: (1) chitosan nanofibrous dressing + transparent film, (2) commercial scaffold + transparent film, and (3) transparent film alone (control). Full-thickness wounds (2 cm × 2 cm) were created on the dorsum, splinted, and covered with dressings. Evaluations at 7, 14, and 21 days included histological analysis, …

Breaking Barriers In Biomanufacturing: A Novel End-To-End Continuous Processing Line, Martin Lobedann, Thomas Kruse

Integrated Continuous Biomanufacturing VII (ICB VII)

Please click Additional Files below to see the full abstract

Multimodal Reprogramming Of The Tumor Microenvironment By Mmr And Dual Checkpoint Blockade In Hepatocellular Carcinoma Models, Mulu Z. Tesfay, Aleksandra Cios, Khandoker Usran Ferdous, Randal S. Shelton, Bahaa Mustafa, Camila C. Simoes, Murat Gokden, Isabelle R. Miousse, Kimberly J. Krager, Marjan Boerma, Alicja Urbaniak, Anuradha Kunthur, Sri Obulareddy, Joshua M. Eichhorn, Steven R. Post, Jean Christopher Chamcheu, Omeed Moaven, Chiswili Y. Chabu, Dan G. Duda, Matteo Conti, Bruno Nardo, Rang Govindarajan, Martin E. Fernandez-Zapico, Lewis R. Roberts, Mitesh J. Borad, Martin J. Cannon, Alexei G. Basnakian, Bolni M. Nagalo

School of Graduate Studies Faculty Publications

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, thus, there is an urgent need to develop more effective therapeutic options for this dismal condition. Tumor-infiltrating lymphocytes (TILs) are associated with improved response to immune checkpoint blockade in HCC, but their low abundance in most cases limits their therapeutic efficacy. Here, we demonstrate, in mice, that low-dose intratumoral immunovirotherapy with the trivalent measles, mumps, and rubella vaccine (MMR) induces superior tumor-growth delay and extended host survival compared to individually administered vaccines for measles, mumps, or rubella viruses. Further, our results show that MMR therapy synergizes with PD-1 and …

Synthetically Expressive: Evaluating Gesture And Voice For Emotion And Empathy In Vr And 2d Scenarios, Haoyang Du, Kiran Chhatre, Christopher Peters, Brian Keegan, Rachel Mcdonnell, Cathy Ennis

Research Outputs: 2025-Present

The creation of virtual humans increasingly leverages automated synthesis of speech and gestures, enabling expressive, adaptable agents that effectively engage users. However, the independent development of voice and gesture generation technologies, alongside the growing popularity of virtual reality (VR), presents significant questions about the integration of these signals and their ability to convey emotional detail in immersive environments. In this paper, we evaluate the influence of real and synthetic gestures and speech, alongside varying levels of immersion (VR vs. 2D displays) and emotional contexts (positive, neutral, negative) on user perceptions. We investigate how immersion affects the perceived match between gestures …

Apostel-R Recommendations For Reporting Retinal Optical Coherence Tomography Studies In Rodents, Frederike Cosima Oertel, Delia Cabrera Debuc, Peter A. Calabresi, Mei Chen, Christian Cordano, Michael Dietrich, Nicolas Feltgen, Oliver Gramlich, Ari J. Green, Janos Groh, Su-Chun Huang, Benjamin Knier, Thomas Korn, Letizia Leocani, Anat Loewenstein, Christian Van Oterendorp, Tunde Peto, Sven Schippling, Leopold Schmetterer, Steffen Schmitz-Valckenberg, Mathias W. Seeliger, Kenneth S. Shindler, Joel Schuman, Mustafa Sindi, Adnan Tufail, Jui-Kai Wang, Sebastian Wolf, Yuyi You, Martin Zinkernagel, Wolf Lagrèze, Philipp Albrecht

Department of Medicine Faculty Papers

BACKGROUND AND OBJECTIVES: Retinal optical coherence tomography (OCT) in rodent models has been used to longitudinally image retinal changes, to define end points for more costly or time-consuming experiments, and to better understand the pathophysiology underlying OCT findings in human diseases. No standardization of rodent OCT reporting currently exists. Here, we aim to establish consensus recommendation for reporting results from retinal OCT studies in rodents.

METHODS: Initial recommendations were developed based on the APOSTEL criteria for quantitative OCT reporting in humans by a core team. Using a modified Delphi process, an expert panel of rodent OCT researchers (N = 31) …

Comparing The Consistency Between Age Estimations Across Various Three-Dimensional Model Creation Methods In An Attempt To Find A Practical Proxy For Physical Remains, Jeanne R. Wood

LSU Master's Theses

The purpose of this study is to determine whether digital three-dimensional models can serve as a viable alternative to physical human remains to allow continued research on fragile physical specimens. As digital three-dimensional models have become increasingly prevalent in anthropological and archaeological research, it is essential to assess their limitations and capabilities, particularly for subjective assessments that rely heavily on visual interpretation (Remondino & El-Hakim, 2006). While previous studies have focused on the use of digital three-dimensional models for quantitative measurements, their effectiveness for subjective analyses remains unclear (Cooper et al., 2003; Sholts et al., 2010; Stull et al., 2014; …

Introductory Chemistry Student Success: Investigating Study Strategies And Evaluating An Informative Utility Value Intervention, Pallavi Nayyar

USF Tampa Graduate Theses and Dissertations

Improving retention in STEM (science, technology, engineering, and mathematics) programs is essential to meet the growing demand for skilled professionals in the domestic workforce. To achieve this, it is critical to understand and address the factors that influence student persistence in STEM degrees. Gateway courses such as general chemistry often serve as early barriers to STEM degree completion, with high rates of attrition that impact not only individual students but also institutions and society. Therefore, the aim of this work was to examine and influence the factors that contribute to student withdrawal from introductory chemistry courses in order to promote …

2025-10-08 Budgets, Boba And Brand New Pricing, Valery Martinez

The Spectator Online

No abstract provided.

Mechanistic Study Of Pexidartinib-Induced Toxicity In Human Hepatic Cells, Si Chen, Yuxi Li, Xilin Li, Nan Mei, Xiaobo He, Matthew S Bryant, Xuan Qin, Feng Li, Lei Guo

Faculty, Staff and Students Publications

Pexidartinib, a tyrosine kinase inhibitor, was approved by the U.S. Food and Drug Administration in 2019 for treating adult patients with symptomatic tenosynovial giant cell tumors. Because of its hepatotoxicity risks, pexidartinib received a boxed warning; however, mechanistic studies on this hepatotoxicity remain limited. In this study, we demonstrate that pexidartinib decreases cell viability in primary human hepatocytes and hepatic HepG2 cells. A 24-h treatment with pexidartinib led to apoptosis in HepG2 cells, as evidenced by increased caspase 3/7 activity and the induction of cleaved PARP and γ-H2A.X. Pexidartinib-induced endoplasmic reticulum (ER) stress was observed at early time points of …

Spartan Daily, October 8, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 20

Re: Butte Priority Soil Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 177 – North Alice Culvert, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Synthetically Expressive: Evaluating Gesture And Voice For Emotion And Empathy In Vr And 2d Scenarios, Haoyang Du, Kiran Chhatre, Christopher Peters, Brian Keegan, Rachel Mcdonnell, Cathy Ennis

Conference papers

The creation of virtual humans increasingly leverages automated synthesis of speech and gestures, enabling expressive, adaptable agents that effectively engage users. However, the independent development of voice and gesture generation technologies, alongside the growing popularity of virtual reality (VR), presents significant questions about the integration of these signals and their ability to convey emotional detail in immersive environments. In this paper, we evaluate the influence of real and synthetic gestures and speech, alongside varying levels of immersion (VR vs. 2D displays) and emotional contexts (positive, neutral, negative) on user perceptions. We investigate how immersion affects the perceived match between gestures …

Messages From The Provost, Georgia Southern University

Messages from the Provost

• Message from the Provost

• GS professor awarded NSF grant to advance protein imaging research

• GS students partner with NASA to develop tech for deep-space missions

• GS post-baccalaureate program helps next generation of coastal scientists wade into research

• Fashion Merchandising student tailors her future following Tyler Perry Studios internship

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Ur- 19 – Butte, Anaconda & Pacific Railway From Montana Street To South Arizona Avenue – Montana Street Adjacent Parcel (Dated August 13, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Bacillus Sp. Sw14 Isolated From Arid Mangroves Sediments Enhances Tomato Plant Growth: Insights From Genome Analysis And Greenhouse Evaluation, Balamurugan Sadaiappan, Qurban Ali, Mahideen Afridi, Munawwar Ali Khan, Sunil Mundra

All Works

Mangroves grow in arid regions with high temperatures, low precipitation, and evaporation. Despite low humidity and high salt concentration, these arid mangroves support diverse microorganisms, including salt-and temperature tolerant. The bacteria isolated from these arid mangroves have potential applications in arid agronomy, which alleviate plant stress and enhance plant growth. In this study, we characterize the genome of previously reported PGP and stress-tolerating bacteria, Bacillus sp. SW14, isolated from mangrove sediments of Umm Al Quwain, United Arab Emirates. Further, we investigated its effects on tomato seed germination and plant growth. Genome size of the strain SW14 is 4.25 MB, with …

Investigation Of Flow Field Near A Type-A Piano Key Weir, S. Hussain, M. S. Quamar, Z. Ahmad

4th International Workshop on Labyrinth and Piano Key Weirs

Piano Key Weirs (PKWs) enhance spillway capacity and induce complex flow patterns around their inlet and outlet keys. This study investigates the flow near a Type-A PKW using Computational Fluid Dynamics (CFD). Velocity fields in the vicinity of the PKW keys were analyzed for different discharges and validated with the experimental results. As flow approaches the inlet key, the streamwise, vertical, and lateral velocity components increase significantly, with the highest velocities near the inlet key. However, near the outlet key the streamwise velocity decreases while the vertical and lateral components increase. For all the discharges, the maximum velocity was observed …

Key Width Ratio Influence On Discharge Coefficients Of Trapezoidal Piano Key Weirs Via Openfoam Simulations, Lisa Lüddecke, Mario Oertel

4th International Workshop on Labyrinth and Piano Key Weirs

Piano key weirs are characterized by complex three-dimensional flow structures with multiple parameters describing their geometry. The variation of these parameters can affect several flow characteristics such as efficiency, energy dissipation and air entrainment. Identifying the optimal geometry for enhanced hydraulic performance represents a significant challenge. Physical or numerical modeling of multiple geometric variants is necessary to identify the relevant optimal parameters. The key width ratio (between an inlet and an outlet key) represents one of the parameters that influences the hydraulic behavior of the piano key weir. In particular, it affects the discharge coefficient, which in turn affects the …

Experimental And Numerical Investigation Of A-Type Rectangular Side Piano Key Weir, Sabir Hussain, Zulfequar Ahmad

4th International Workshop on Labyrinth and Piano Key Weirs

A side weir is a structure installed along the side wall of a channel, serving multiple purposes, such as raising water levels for irrigation and drainage and diverting excess flow from rivers or channels during floods. Most studies have focused so far on linear rectangular and labyrinth side weirs, with relatively limited research conducted on side Piano key weirs. In this paper, an experimental and numerical simulation was performed on an A-type rectangular side piano key weir and a rectangular sharp-crested side weir. The diversion discharge of Piano key side weirs was within the range of ± 10% with numerical …

Sensitivity Analysis Of Piano-Key Weirs Design: Optimizing Discharge Performance Through Cfd Modeling And Empirical Insights, Fatna Oukaili, Yvan Bercovitz, Thomas Fonty, Benoit Blancher, Julien Vermeulen

4th International Workshop on Labyrinth and Piano Key Weirs

Piano-key weirs (PKWs) are widely recognized for their efficiency in enhancing spillway discharge capacity while maintaining a compact footprint. This study focuses on a parametric and sensitivity analysis of PKW discharge performance, exploring the influence of key design parameters on hydraulic behavior. By integrating experimental data with advanced computational fluid dynamics (CFD) modeling using the open-source code_saturne software, we aim to refine predictive capabilities and establish guidelines for effective PKW design. The analysis emphasizes understanding the interplay between PKW geometry and flow characteristics. The analysis considers a range of geometrical configurations, including variations in key width ratios, and inlet-to-outlet dimensions, …

An Innovative Use Of Piano Key Weirs Or Labyrinth Weirs For Long Dams In Plains, Michel Ho Ta Khanh

4th International Workshop on Labyrinth and Piano Key Weirs

Piano Key Weirs (PKW) are labyrinth type weirs but with upstream and/or downstream overhangs which allow them to have a reduced footprint at their base. The new solution of a combination of gates and PKW (or labyrinth weir) for a long dams has many advantages of costs for investment, operation and safety during high floods. If a new dam is built on a broad river where a large footprint is possible, the choice between a PKW and a labyrinth weir can arise as the difference of specific discharges of the two alternatives are relatively small and the construction of the …

Whose Histories Will A Genai Tool Generate? Prompting Chatgpt-4 For Diverse History Lesson Plans For The Cold War Space Race, Robert W. Maloy, Sai Gattupalli, Torrey Trust

The Councilor: A National Journal of the Social Studies

This paper explores strategies for teachers to use in prompting ChatGPT-4 to develop diverse history lesson plans for the Cold War Space Race. Prior research showed that when given a single, broadly phrased “design a lesson plan” prompt, chatbots are less likely to generate material about experiences of African Americans, women, and other historically marginalized groups. We tried two alternative prompting strategies: a) Change the wording of the prompt to incorporate James Banks’ Levels of Multicultural Content Model, and b) Change the source of the content for the prompt by using teacher-curated materials from an open online wikispace, resourcesforhistoryteachers that …

Tackling Mississippi’S Brain Drain: A Problem-Based Geographic Inquiry Approach For Social Studies Educators, James B. Howell, Lamont E. Maddox, J.O. Joby Bass, Benjamin H. Austin, Skye Morgan

The Councilor: A National Journal of the Social Studies

This paper offers an overview of brain drain as a social problem and shares insights on integrating problem-based geographic inquiry (PBGI) into classrooms. It aims to help social studies teachers: 1) understand brain drain and its geographic relevance, 2) explore how brain drain serves as an engaging public policy issue for PBGI, and 3) identify resources to support problem-based learning. Additionally, the paper provides practical recommendations on designing effective PBGI units, selecting relevant resources, and utilizing geographic tools to foster civic and geographic reasoning skills. Investigating human migration associated with brain drain using a public policy lens should help students …

An Innovative Association Of Fusegate And Pk-Weir, F. Lempérière, A. Chapuis, F. Del Rey, C. Bessière

4th International Workshop on Labyrinth and Piano Key Weirs

The combination on the same dam of Piano Key weir (PK-Weir) and fusible structures offers a highly effective passive solution for managing flood discharges. This concept first introduced by Hydrocoop in 2015 as « Innovative Associated Spillways » can leverage the strength of each system. More than 30 years after its first application, the returns of experience of the Hydroplus Fusegate® system applications on more than 80 dams in 25 different countries have confirmed their reliability in terms of sequentially overturning on the downstream side for the correct design flood. With their high discharge capacity at low head, PK-Weirs optimize …

Enhancing The Hydraulic Efficiency Of Piano Key Weir (Pkw) — Some Research Achievements, James Yang, Shicheng Li, Anders Ansell, Erik Skepparkrans, Chen Lin

4th International Workshop on Labyrinth and Piano Key Weirs

As an effective flood control structure, the piano key weir (PKW) typically features a rectangular planform for its overhangs. However, this design offers room for improvement. To enhance hydraulic efficiency, two modified PKW layouts are proposed. In the first, the floor of each key is lowered with a semicircular cross-section, forming an elliptical planform and crest. In the second, the floor is lowered with an isosceles triangular prism, creating an equilateral triangular overhang. Both modified PKW models, manufactured by 3D printing, were tested in a large-scale experimental setup. Compared to the reference weir, the elliptical-overhang PKW increases the developed crest …

Theoretical And Experimental Studies Of Non-Rectilinear Weirs -From Labyrinth To Pk-Weir, Ahmed Ouamane, François Lempérière

4th International Workshop on Labyrinth and Piano Key Weirs

Free-flow rectilinear spillways, while simpler and safer than gated or shaft spillways, have a low specific discharge, requiring a significant water head and resulting in a storage loss of more than 20% for some small reservoirs. To overcome this drawback, labyrinth weirs provide an effective alternative, allowing high discharge under a reduced head while maintaining lower construction and maintenance costs. For several decades, global research has focused on optimizing their design. In this context, a research project was initiated in 1995 at the University of Biskra to enhance the understanding of the hydraulic behavior of these structures. This project was …

2023 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Physical Model Investigations On Nappe Instabilities At Labyrinth Weirs, Michael Gebhardt, Fabian Belzner

4th International Workshop on Labyrinth and Piano Key Weirs

Free overflow hydraulic structures operating at low heads tend to develop nappe instabilities when there is no ventilation. A detailed investigation has been undertaken with a relatively large-scale labyrinth weir in the hydraulic laboratory of the BAW. A quarter-round crest was selected, because nappe instabilities mainly occur at sharp-crested weirs, which favor the development of an air pocket behind the nappe. The headwater ratios for which nappe instabilities could be observed were determined. Pressure fluctuations were measured and the frequencies determined. Adding splitters to the crest is one way to vent the air pocket and to avoid vibrations. Another possibility …

Review Of Morganeering, Or The Triumph Of The Trust: A Satirical Burlesque On The Worship Of Wealth, Jonathan Baldwin

Communal Societies

No abstract provided.