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Sailors And Scholars: The History Of The U.S. Naval War College, 1884–2009, Vol. 1, John Hattendorf, B. Mitchell Simpson Iii, John R. Wadleigh Nov 2025

Sailors And Scholars: The History Of The U.S. Naval War College, 1884–2009, Vol. 1, John Hattendorf, B. Mitchell Simpson Iii, John R. Wadleigh

Sailors and Scholars, Second Edition

Volume I, 1884–1984: The First Century, covers from the Naval War College’s founding during the era of Luce and Mahan through its centennial anniversary during the Cold War, detailing how the College came to be widely acclaimed as the premier center of professional naval education and thought.


A Convolutional Neural Network Approach To Breast Cancer Tumor Boundary Detection, James Leah Matlosz Nov 2025

A Convolutional Neural Network Approach To Breast Cancer Tumor Boundary Detection, James Leah Matlosz

Master's Theses

Breast cancer is the second most common form of cancer and often goes undetected in its initial stages due to its subtle symptoms. As the tumors grow, they become more difficult to surgically remove with clean borders. To minimize the chance of recurrence, a 2D convolutional neural network is developed in this work for delineating tumor boundaries. Specifically, the U-shaped network model is trained, validated, and tested with longitudinal MRI scans of patients diagnosed with breast cancer and undergoing neoadjuvant therapy. For training, image masks were generated as ground truths using signal enhancement ratio segmentation, thresholding, and contour detection. The …


Up Los Baños Journal, Volume 23 - Frontiers In Industrial Engineering Nov 2025

Up Los Baños Journal, Volume 23 - Frontiers In Industrial Engineering

U.P. Los Baños Journal

Editorial Note

The University Publications Office is honored to present the UP Los Baños Journal, Volume XXIII Special Issue: “Frontiers in Industrial Engineering. The special issue marks a significant milestone for the Department of Industrial Engineering as its celebrates their 25th Anniversary.

We commend the Department for navigating the challenges of rapid technological change, global uncertainty, and the urgent call for sustainable development. With its strong academic foundation and commitment to societal impact, the Department is well positioned to continue to lead in the transformative efforts in the field.

We are grateful to the Department of Industrial Engineering for its …


Managing The Personalization Paradox: Lessons From Spotify’S Ai Dj, Anirban Mukherjee, Hannah H. Chang, Jonathan Wibowo Nov 2025

Managing The Personalization Paradox: Lessons From Spotify’S Ai Dj, Anirban Mukherjee, Hannah H. Chang, Jonathan Wibowo

Research Collection Lee Kong Chian School Of Business

This case study uses Spotify’s AI DJ to examine the “personalization paradox,” where product features designed to deepen user connection can instead cause alienation. An analysis of over 1,400 user comments identifies three core frictions: a perceived loss of user agency, mismanaged expectations for the human-like AI, and a scalability bottleneck that led to repetitive content. Students are placed in the role of a product manager tasked with developing a prioritized roadmap to address these issues, forcing them to grapple with the critical trade-offs between technological capability and user psychology.


The Moderating Role Of Affective Engagement On The Relationship Between Learning Autonomy And Cognitive Engagement, Neal Nikko D. Espejo Nov 2025

The Moderating Role Of Affective Engagement On The Relationship Between Learning Autonomy And Cognitive Engagement, Neal Nikko D. Espejo

Ateneo Institute for The Science and Art of Learning and Teaching

The study explores the moderating role of affective engagement on the relationship between learning autonomy and cognitive engagement among university students. Grounded in Self-Determination Theory, the research examines how affective engagement, characterized by emotional connection and enjoyment in learning, influences the effect of learning autonomy on cognitive engagement. The sample consisted of 178 business and information management students from a university in the Philippines, selected through purposive sampling. Using validated scales for learning autonomy, affective engagement, and cognitive engagement, data was analyzed through moderation techniques and simple slope analysis. The findings reveal that while both learning autonomy and affective engagement …


Stress-Relaxation And Failure Properties Of Spinal Ligaments In Pigs With And Without Scoliosis-Like Deformity, Christian D'Andrea, Mattan Orbach, Dogerno Norceide, Madeline Boyes, Axel Moore, Jacob Jordan, Thomas Schaer, Anita Singh, Patrick Cahill, Edward Vresilovic, Brian Snyder, Sriram Balasubramanian Nov 2025

Stress-Relaxation And Failure Properties Of Spinal Ligaments In Pigs With And Without Scoliosis-Like Deformity, Christian D'Andrea, Mattan Orbach, Dogerno Norceide, Madeline Boyes, Axel Moore, Jacob Jordan, Thomas Schaer, Anita Singh, Patrick Cahill, Edward Vresilovic, Brian Snyder, Sriram Balasubramanian

Student Papers, Posters & Projects

This study addresses the need for accurate tissue material properties in computational models of the spine. Fundamental to functional spinal unit (FSU) biomechanics are the stress-relaxation and failure properties of the interspinous and intertransverse ligaments (ISL and ITL, respectively). These were measured and compared in normative and scoliotic spines using a Yorkshire pig model. Skeletally immature female pig spines were posterolaterally tethered to induce scoliosis. 23 ISLs and 17 ITLs excised from normative and scoliotic spine segments underwent stress-relaxation and failure tests. Group comparisons tested the effects of scoliosis (magnitude, convexity versus concavity), spinal level (thoracic, lumbar), and pig age. …


Broadening Workforce Participation In Transportation: Challenges And Strategies, Jodi Godfrey, Stephanie Ivey Nov 2025

Broadening Workforce Participation In Transportation: Challenges And Strategies, Jodi Godfrey, Stephanie Ivey

Mineta Transportation Institute

Attracting and retaining a diverse, skilled workforce remains one of the most pressing challenges in the transportation industry. A new MTI-led California State University Transportation Consortium report examines why workforce participation gaps persist and identifies practical strategies organizations can implement to address them. Drawing on an extensive literature review, a nationwide industry survey with 996 respondents, and in-depth interviews with 15 transportation professionals, the study highlights both the barriers and the solutions to workforce participation. The findings emphasize that open dialogue, intentional investment, and inclusive workplace policies can help transform industry culture, making transportation careers more appealing to a broader …


Providing Spatial Support During A Major Cholera Outbreak In Port-Au-Prince, Haiti: Creative Mapping Solutions In A Challenging Data Poor Environment, Andrew Curtis, Jayakrishnan Ajayakumar Nov 2025

Providing Spatial Support During A Major Cholera Outbreak In Port-Au-Prince, Haiti: Creative Mapping Solutions In A Challenging Data Poor Environment, Andrew Curtis, Jayakrishnan Ajayakumar

Faculty Scholarship

In this paper we describe the spatial data challenges faced in terms of providing accurate and timely analysis for a clinic during a cholera epidemic that spread through Port au Prince, Haiti in late 2022. This “triage” spatial epidemiology involved developing a bespoke geocoder that allowed for weekly maps of spread to be created in near real time. Resulting case data were also analyzed using a novel grid heatmapping approach which considers the epidemiological curve for each neighborhood. Adding further complexity during this period to both the data generation, and explaining cholera amplification and spread patterns, was a rising gang …


Neonatal Unit Human Resources: Coverage For Six Cadres And Trends For Staff-To-Baby Ratios In 65 Neonatal Units Implementing With Nest360 In Kenya, Malawi, Nigeria, And Tanzania, Rebecca Penzias, Eric Ohuma, Opeyemi Odedere, Olabisi Dosunmu, George Okello, Hannah Mwaniki, Robert Tillya, Josephine Shabani, Vincent Ochieng, Ekran Rashid, William Macharia Nov 2025

Neonatal Unit Human Resources: Coverage For Six Cadres And Trends For Staff-To-Baby Ratios In 65 Neonatal Units Implementing With Nest360 In Kenya, Malawi, Nigeria, And Tanzania, Rebecca Penzias, Eric Ohuma, Opeyemi Odedere, Olabisi Dosunmu, George Okello, Hannah Mwaniki, Robert Tillya, Josephine Shabani, Vincent Ochieng, Ekran Rashid, William Macharia

Paediatrics and Child Health, East Africa

Background: Implementing small and sick newborn care (SSNC) requires skilled health workers; however, there is a shortage, adversely impacting patient outcomes and health worker wellbeing. There are limited data and no cur‑ rent World Health Organization (WHO) standards for staftobaby ratios in neonatal units in low and middleincome countries (LMICs) to inform policy, planning, and investment.

Methods: In 65 neonatal units (36 in Malawi, 13 in Kenya, 7 in Tanzania, and 9 in Nigeria), a health facility assessment (HFA) for SSNC and governmentled quality improvement (QI) processes were implemented. Stafng data were col‑ lated from baseline HFA (Sept 2019–March 2021) …


Provost's Scholarly Dissemination Report: October 2025, Une Office Of The Provost, Sonya Durney Nov 2025

Provost's Scholarly Dissemination Report: October 2025, Une Office Of The Provost, Sonya Durney

UNE Provost's Reports

Scholarly dissemination report of UNE-authored publications during the period of May through October, 2025. Prepared for the Academic, Student, and Research Affairs Committee Report November 2025.


Gamma Sigma Delta, Nebraska Chapter Newsletter, Issue #68 November 2025 Nov 2025

Gamma Sigma Delta, Nebraska Chapter Newsletter, Issue #68 November 2025

Gamma Sigma Delta, Nebraska Chapter: Newsletters

President's message, Deb VanOverbeke
Membership Information
2025 Outstanding Graduate Student Award Nomination Solicitation
2025 Teaching Award nomination solicitation
2025 Research Award nomination solicitation
2025 Extension Award nomination solicitation
2025 Award of Merit nomination solicitation
Gamma Sigma Delta Committees 2025
Annual Dues Notice
Membership Info and Dues
Student Award Fund solicitation
In Memoriam: Wayne W. Oberg (September 8, 1948 - February 21, 2025); Robert M. "Bob" Scriven (June 26, 1936 - August 29, 2025)
Pledge and Honor Cords
Save the Date: Initiation and Awards Reception


Collaborative Opportunity: Growing A Community Around Integrated Engineering, Rebecca Bates, Emanuela Tilley, Jenna Carpenter, Susan Lord Nov 2025

Collaborative Opportunity: Growing A Community Around Integrated Engineering, Rebecca Bates, Emanuela Tilley, Jenna Carpenter, Susan Lord

Integrated Engineering Department Publications

Integrated Engineering is emerging across the world. One commonality among programs is a desire to innovate in ways not seen as possible within traditional engineering disciplines. The inclusive pedagogical approaches seen in integrated engineering programs offer promise for truly transforming engineering education. These student-centered approaches align with caring pedagogies and provide sustainable infrastructure for supporting diverse student experiences. Innovation in engineering education can be challenging to implement and can be challenging to sustain. Community support can make a positive difference. Building on a series of community conversations at multiple international conferences as well as an international symposium in London during …


Finding Better Solutions: How Algorithms Tackle Complex Problems, Mahmoud El-Hashash Nov 2025

Finding Better Solutions: How Algorithms Tackle Complex Problems, Mahmoud El-Hashash

Bridgewater Review

Have you ever tried to solve a puzzle, only to realize that every time you got close, you ended up stuck in the same dead end? Mathematicians and scientists face a similar challenge when trying to solve optimization problems, finding the “best” solution among countless possibilities. These problems arise everywhere, from designing airplanes to training artificial intelligence systems.


Retrofitting Through The Facade: An Integrated Architectural Retrofit Assesment, Marie Danielle Danso Nov 2025

Retrofitting Through The Facade: An Integrated Architectural Retrofit Assesment, Marie Danielle Danso

2025 Fall Honors Capstones Projects - Archive

Dynamic façades can be used as architectural tools to reduce heat gain in a building. This kinetic design reforms energy efficiency and can improve user comfort. Dynamic façades change their form and appearance in response to the environment. They can reduce stress on heating and cooling systems by mitigating the amount of solar radiation a building receives. Additionally, this architectural approach can control internal heating and cooling loads by managing the intake of sunlight. This study investigates a dynamic façade as an architectural tool to substantially reduce the heat gain of the Engineering Research Building on the campus of The …


Scaling Up Biomedical Vision-Language Models: Fine-Tuning, Instruction Tuning, And Multi-Modal Learning, Cheng Peng, Kai Zhang, Mengxian Lyu, Hongfang Liu, Lichao Sun, Yonghui Wu Nov 2025

Scaling Up Biomedical Vision-Language Models: Fine-Tuning, Instruction Tuning, And Multi-Modal Learning, Cheng Peng, Kai Zhang, Mengxian Lyu, Hongfang Liu, Lichao Sun, Yonghui Wu

Faculty, Staff and Student Publications

Objective: To advance biomedical vision language model capabilities through scaling up, fine-tuning, and instruction tuning, develop vision-language models with improved performance in handling long text, explore strategies to efficiently adopt vision language models for diverse multi-modal biomedical tasks, and examine the zero-shot learning performance.

Methods: We developed two biomedical vision language models, BiomedGPT-Large and BiomedGPT-XLarge, based on an encoder-decoder-based transformer architecture. We fine-tuned the two models on 23 benchmark datasets from 6 multi-modal biomedical tasks, including one image-only task (image classification), three language-only tasks (text understanding, text summarization, and question answering), and two vision-language tasks (visual question answering and image …


Temporal And Heterogeneous Graph Neural Network For Remaining Useful Life Prediction, Zhihao Wen, Yuan Fang, Pengcheng Wei, Fayao Liu, Zhenghua Chen, Min Wu Nov 2025

Temporal And Heterogeneous Graph Neural Network For Remaining Useful Life Prediction, Zhihao Wen, Yuan Fang, Pengcheng Wei, Fayao Liu, Zhenghua Chen, Min Wu

Research Collection School Of Computing and Information Systems

Predicting remaining useful life (RUL) plays a crucial role in the prognostics and health management of industrial systems that involve a variety of interrelated sensors. Given a constant stream of time-series sensory data from such systems, deep learning (DL) models have risen to prominence at identifying complex, nonlinear temporal dependencies in these data. In addition to the temporal dependencies of individual sensors, spatial dependencies emerge as important correlations among these sensors, which can be naturally modeled by a temporal graph that describes time-varying spatial relationships. However, the majority of existing studies have relied on capturing discrete snapshots of this temporal …


Seeing The Humanity In Each Object: Finding Justice Amid The Law, Gideon Taylor, Ruth J. Weinberger Nov 2025

Seeing The Humanity In Each Object: Finding Justice Amid The Law, Gideon Taylor, Ruth J. Weinberger

Fordham Law Review

The restitution of Nazi-looted cultural and religious property remains an important aspect of providing a measure of justice for Holocaust victims and their heirs. The United States has played a leading role, from early postwar restitution efforts to shaping international principles, such as the Washington Conference Principles on Nazi-Confiscated Art (the “Washington Conference Principles”), the Terezin Declaration, and the recent Best Practices for the Washington Conference Principles. Yet restitution within the United States continues to rely largely on litigation, with varying outcomes and limited provenance research compared to some European countries. The following Essay examines America’s contributions and challenges and …


Correctional System Involvement And Health Outcomes, Sarah Mason Eck ,Ph.D Nov 2025

Correctional System Involvement And Health Outcomes, Sarah Mason Eck ,Ph.D

All Materials

The Institute for Health Policy and Practice (IHPP) at the University System of New Hampshire commissioned Scientific Health to conduct an evidence-based review of the relationship between criminal justice system involvement and health outcomes. This research synthesized findings from recently published, peer-reviewed academic literature and relevant reports to examine how correctional system involvement affects physical health, mental health, and overall well-being among incarcerated individuals, their families, and communities. The review identified common themes related to behavioral health, chronic conditions, and systemic impacts, providing insight into the broader health implications of mass incarceration and deinstitutionalization. These findings aim to inform policy …


Multiscale 3d Whole Joint Cellular And Molecular Mapping Reveals Disease-Specific Neurovascular Plasticity Underlying The Structure-Pain Relationship, Peng Chen, Jiaxin Chai, Abirami Soundararajan, R. Glenn Hepfer, Benjamin Kheyfets, Jiaxin Hu, Ishraq Alshanqiti, Swarnalakshmi Raman, Ikue Tosa, Jun Tae Huh, Matthew Yee, Brooke J. Damon, Shangping Wang, Yu Shin Kim, Man-Kyo Chung, Mildred C. Embree, Janice S. Lee, Tong Ye, Hai Yao Nov 2025

Multiscale 3d Whole Joint Cellular And Molecular Mapping Reveals Disease-Specific Neurovascular Plasticity Underlying The Structure-Pain Relationship, Peng Chen, Jiaxin Chai, Abirami Soundararajan, R. Glenn Hepfer, Benjamin Kheyfets, Jiaxin Hu, Ishraq Alshanqiti, Swarnalakshmi Raman, Ikue Tosa, Jun Tae Huh, Matthew Yee, Brooke J. Damon, Shangping Wang, Yu Shin Kim, Man-Kyo Chung, Mildred C. Embree, Janice S. Lee, Tong Ye, Hai Yao

Publications

Understanding musculoskeletal joints from a 3D multiscale perspective, from molecular to anatomical levels, is essential for resolving the confounding relationships between structure and pain, elucidating mechanisms regulating joint health and diseases, and developing new treatment strategies. Here, a musculoskeletal joint immunostaining and clearing (MUSIC) method specifically developed to overcome key challenges of immunostaining and optical clearing of intact joints are introduced. Coupled with large-field light sheet microscopy, this approach achieves 3D high-resolution, microscale neurovascular mapping within the context of whole-joint anatomy without the need for image coregistration across various joints, including temporomandibular joints, knees, and spines, and multiple species, including …


Harnessing Electrochemical Hydrogen Evolution In Α-Fe2o3/2h–Mos2 Heterojunction: A Theoretical And Experimental Study On Electronic Modulation And Basal Plane Activation, Mohamed Sayed, Ossama Metwalli, Sameh O. Abdellatif, Kai Yin, Mohamed Saber, Ahmed Khalil, Hossam Abdelwahan Nov 2025

Harnessing Electrochemical Hydrogen Evolution In Α-Fe2o3/2h–Mos2 Heterojunction: A Theoretical And Experimental Study On Electronic Modulation And Basal Plane Activation, Mohamed Sayed, Ossama Metwalli, Sameh O. Abdellatif, Kai Yin, Mohamed Saber, Ahmed Khalil, Hossam Abdelwahan

Electrical Engineering

Hydrogen production through water electrolysis is a promising method for storing renewable energy and reducing greenhouse gas emissions. However, the efficiency and stability of hydrogen production electrodes remain challenging issues. In this study, we present a rationally designed α-Fe2O3/2H–MoS2 heterojunction that unlocks the electrocatalytic potential of the inert basal plane of the semiconducting 2H–MoS2 phase. The heterostructure, synthesized via a facile hydrothermal method, features α-Fe2O3 nanocubes anchored onto flowerlike 2H–MoS2 nanosheets. The electrochemical performance of the α-Fe2O3/2H–MoS2 heterojunction electrode was evaluated by linear sweep voltammetry, Tafel polarization, and electrochemical impedance spectroscopy. The results showed that the α-Fe2O3/2H–MoS2 electrode exhibited lower …


Photochemical And Electrochemical Assessment Of Uio-66-Nh₂/G-C₃N₄ Thin-Film Heterostructures As Potential Candidates For Hydrogen Evolution: An Experimental Study Augmented By Dft Insights, Nour Abouseada, Maryam Galal, Sameh O. Abdellatif, Khaled Kirah Nov 2025

Photochemical And Electrochemical Assessment Of Uio-66-Nh₂/G-C₃N₄ Thin-Film Heterostructures As Potential Candidates For Hydrogen Evolution: An Experimental Study Augmented By Dft Insights, Nour Abouseada, Maryam Galal, Sameh O. Abdellatif, Khaled Kirah

Electrical Engineering

The global shift towards carbon-neutral energy systems has catalyzed an intensified focus on sustainable hydrogen production, with photo and electrochemical water splitting emerging as a particularly promising pathway. This study elucidates the design, simulation, and synthesis of advanced photo and electrocatalytic materials tailored for the hydrogen evolution reaction (HER), concentrating on heterostructures formed by zirconium-based metal-organic frameworks (MOFs)— specifically, UiO-66 and its amine-functionalized derivative, UiO-66-NH₂—in conjunction with graphitic carbon nitride (g-C₃N₄). Employing density functional theory (DFT) simulations, we pre-screened the electronic properties of the MOFs, revealing that amine functionalization significantly narrows the bandgap and optimizes band alignment, thereby enhancing photocatalytic …


Transformative Solidarity: Confronting Neoliberal Hegemony In Urban Schools With Constructivism And Critical Pedagogy, Ryan J. Lundell, Pedro Nava, Jonathan Montoya Nov 2025

Transformative Solidarity: Confronting Neoliberal Hegemony In Urban Schools With Constructivism And Critical Pedagogy, Ryan J. Lundell, Pedro Nava, Jonathan Montoya

Educational Leadership

Neoliberalism is more than a bundle of economic policies; it is a hegemonic ideology that permeates institutions and relationships, creating isolation and inequality (Brown, Undoing the demos: Neoliberalism’s stealth revolution, Zone Books, 2017; Han, Psychopolitics: Neoliberalism and new technologies of power, Verso, 2017). Neoliberal hegemony in urban schools limits student learning and propagates the purpose of education as the creation of human capital, not a socially aware citizenry (Brown, Undoing the demos: Neoliberalism’s stealth revolution, Zone Books, 2017); this creates a depoliticized labor force that strives for self-optimization rather than solidarity (Han, Psychopolitics: Neoliberalism and new technologies of power, Verso, …


Une Library Services Quarterly Report November 2025, Une Library Services Nov 2025

Une Library Services Quarterly Report November 2025, Une Library Services

Quarterly Reports

Highlights of accomplishments of the University of New England's Library Services department.


Sailors And Scholars: The History Of The U.S. Naval War College, 1884–2009, Vol. 2, John Hattendorf Nov 2025

Sailors And Scholars: The History Of The U.S. Naval War College, 1884–2009, Vol. 2, John Hattendorf

Sailors and Scholars, Second Edition

Volume II, 1984–2009, brings this history of the Naval War College into the modern era. For over 125 years, the institution has left its mark on maritime strategy and the naval profession in the United States. This volume contains chronological appendices listing significant events, College leaders, and distinguished graduates.


Truck Drivers And Autonomous Trucks: A Topic Modeling Analysis Of Truck Driver Posts, Noah Britt, Amy M. Schuster, Shubham Agrawal, Chu-Hsiang Chang, Jenna A. Van Fossen, Elizabeth A. Mack, Sheila R. Cotten Nov 2025

Truck Drivers And Autonomous Trucks: A Topic Modeling Analysis Of Truck Driver Posts, Noah Britt, Amy M. Schuster, Shubham Agrawal, Chu-Hsiang Chang, Jenna A. Van Fossen, Elizabeth A. Mack, Sheila R. Cotten

Publications

Social media provides a rich, alternative data source to interviews or survey-based research to study hard-to-reach populations (e.g., truck drivers, because of their transient work structure and unique subculture). This study uses public social media posts from the largest trucking forum in the United States to examine truck drivers’ views on autonomous trucks (ATs), which are poised to transform the trucking industry. We expand on traditional qualitative strategies of analyzing social media data by combining newer methods, including BERT-based topic modeling, sentiment analysis, stance detection, emotion analysis, topic similarity, and location analysis through a social interaction network, to analyze a …


Bridging The (U)Rban And (I)Ndividual To Transform Cities, Lily Kong Nov 2025

Bridging The (U)Rban And (I)Ndividual To Transform Cities, Lily Kong

Asian Management Insights

Urban transformation efforts are often focused on infrastructure and technology issues, overlooking how the individual experiences the city. An interview with SMU President Professor Lily Kong.


Delivering Urban Transformation For The Individual, Havovi Joshi Nov 2025

Delivering Urban Transformation For The Individual, Havovi Joshi

Asian Management Insights

The call for urban transformation has never been more pressing.


Modernizing Family Courts: How Technology-Driven Triage Improves Access To Justice For Self- Represented Litigants And Enhances Efficiency For Lawyers, Ayyoub Ajmi, Alicia Davis Nov 2025

Modernizing Family Courts: How Technology-Driven Triage Improves Access To Justice For Self- Represented Litigants And Enhances Efficiency For Lawyers, Ayyoub Ajmi, Alicia Davis

Faculty Works

Family courts are overwhelmed by rising caseloads, increasing parental conflict, and limited judicial resources. With 80–90% of litigants self-represented (SRLs), case delays and inefficiencies affect all parties, including those with private counsel. High-conflict cases make up 10–30% of dockets, consuming judicial time and worsening outcomes for families, especially children. This article explores the Family Court Services Portal, a technology-driven triage tool designed to streamline family case processing, improve access to justice, and help courts allocate re- sources effectively. The portal integrates pre-screening triage automation, guiding parties through structured issue identification to support proportional judicial intervention and informed case management. Developed …


From Human To Mouse And Back Again: Genetic And Genomic Ta(I)Les Of Islet Dysfunction In Type 2 Diabetes., Romy Kursawe, Khushdeep Bandesh, Sai Nivedita Krishnan, Kevin S Liu, Redwan M Bhuiyan, Michael L. Stitzel Nov 2025

From Human To Mouse And Back Again: Genetic And Genomic Ta(I)Les Of Islet Dysfunction In Type 2 Diabetes., Romy Kursawe, Khushdeep Bandesh, Sai Nivedita Krishnan, Kevin S Liu, Redwan M Bhuiyan, Michael L. Stitzel

Faculty Research 2025

Type 2 diabetes (T2D) is a complex genetic disease with substantial environmental inputs leading to glucose homeostasis defects. Insulin production is central to proper glucose control, and islet cell dysfunction and death lie at the nexus of T2D genetics and pathophysiology. Comprehensive identification of genes and pathways contributing to these processes is essential for mechanistic understanding and therapeutic targeting. Here, we summarize the latest human and mouse T2D genetic and genomic studies and assess how these parallel variant-to-function efforts and associated data contribute convergent or complementary insights and new opportunities to dissect T2D islet (dys)function. We distill mechanistic and phenotypic …


Neurometabolic And Vascular Dysfunction As An Early Diagnostic For Alzheimer's Disease And Related Dementias., Juan Antonio K Chong Chie, Scott A Persohn, Ravi S Pandey, Gregory W. Carter, Olivia R Simcox, Paul Salama, Paul R Territo, The Alzheimer’S Disease Neuroimaging Initiative Nov 2025

Neurometabolic And Vascular Dysfunction As An Early Diagnostic For Alzheimer's Disease And Related Dementias., Juan Antonio K Chong Chie, Scott A Persohn, Ravi S Pandey, Gregory W. Carter, Olivia R Simcox, Paul Salama, Paul R Territo, The Alzheimer’S Disease Neuroimaging Initiative

Faculty Research 2025

INTRODUCTION: Recent studies suggest that the brain undergoes anatomical and functional restructuring, resulting in neurometabolic and vascular dysregulation (MVD) prior to amyloid beta accumulation, which begins at an early age and leads to the onset of Alzheimer's disease (AD).

METHODS: Using a retrospective clinical population (n = 403) from the Alzheimer's Disease Neuroimaging Initiative, cerebral perfusion and metabolism changes across 59 brain regions were evaluated from clinical studies. Results were verified by transcriptomic signatures and clinical cognitive assessments.

RESULTS: Our findings suggest that disease progression follows a stage-dependent MVD pattern that can identify at-risk regions. Although each region progresses at …