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Towards Robust Autonomous Systems: Handling Multi-Modal Uncertainties In Gps-Denied Environments, Vivya Kalidindi Nov 2025

Towards Robust Autonomous Systems: Handling Multi-Modal Uncertainties In Gps-Denied Environments, Vivya Kalidindi

Doctoral Dissertations

This dissertation focuses on designing a robust and uncertainty-aware framework for autonomous systems operating in GPS-denied environments, such as indoor infrastructures, underground tunnels, and lunar surfaces. The proposed framework addresses the challenges posed by multi-modal uncertainties, including sensor noise, distributional shifts under adverse conditions, and conflicting decision-making preferences. These challenges compromise the reliability and adaptability of autonomous platforms. To overcome these challenges, the proposed framework adopts a layered architecture that integrates advanced methodologies across the sensing, perception, and decision-making layers. At the sensing layer, an Edge-Kalman Filter combined with a density ratio-based update mechanism is employed to reduce aleatoric uncertainty …

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Investigation Of Electrochemical Corrosion Fatigue Mitigation Strategies For Mild Carbon Steel, Joel Andrew Hudson Nov 2025

Investigation Of Electrochemical Corrosion Fatigue Mitigation Strategies For Mild Carbon Steel, Joel Andrew Hudson

Doctoral Dissertations

Corrosion fatigue remains a critical durability challenge for steels used in boiler tubes and other safety-critical components, where the interaction of cyclic stresses and corrosive environments accelerates material degradation. This dissertation comprises three experimental studies aimed at advancing mitigation strategies and test methodologies: (1) enhancing corrosion resistance through electrodeposited Fe-Ni anodic coatings, (2) inducing synthetic crack closure to suppress fatigue crack growth, and (3) developing an accessible, low-cost, automated testing system to investigate environmentally assisted cracking (EAC) under controlled laboratory conditions. The first study examined the corrosion behavior of Fe and Fe-Ni electrodeposits synthesized from sulfate-based baths and applied to …

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Development Of New Design Criteria For Coastal Highway Embankment Under Wave-Induced Loading, Udaya Bilas Panta Nov 2025

Development Of New Design Criteria For Coastal Highway Embankment Under Wave-Induced Loading, Udaya Bilas Panta

Master's Theses

In the face of intensifying hurricanes and rising sea levels, Louisiana’s coastal highways, lifelines for communities and commerce, stand increasingly vulnerable. This thesis introduces a pioneering methodology for designing geosynthetic-reinforced highway embankments capable of withstanding wave-induced loading and rapid drawdown scenarios, the most critical failure condition identified in coastal environments. By integrating statistical wave modeling, advanced numerical simulations using SEEP/W and SLOPE/W, and a comprehensive parametric analysis, the study develops a novel hybrid regression formula that accurately predicts optimal reinforcement lengths based on site-specific geotechnical and hydraulic parameters. Validated against Hurricane Katrina data and real-world soil profiles from Cameron Parish, …

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The Potential Co-Occurrence Of Perfectionism, Food Insecurity, And Gpa With Orthorexia Nervosa Risk, Samantha Kay Gould Nov 2025

The Potential Co-Occurrence Of Perfectionism, Food Insecurity, And Gpa With Orthorexia Nervosa Risk, Samantha Kay Gould

Master's Theses

There are indeterminate risk, prevalence, and correlation data on orthorexia nervosa (ON) as shown by current literature on disordered eating (Rodgers et al., 2021). As a roughly defined disordered eating pattern, ON may be better understood after identifying associations among other attributes in a college student sample (Abdullah et al., 2020; Mavrandrea & Gonidakis, 2023; Parra-Fernández, 2019; Rogowska et al., 2021). A cooccurrence and influence of perfectionism, food insecurity, and grade point average (GPA) with ON risk was hypothesized since current literature suggests college students exhibit each of these characteristics independently (Abdullah et al., 2020; Ambwani et al., 2019; Caferoglu …

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Exploring The Effectiveness Of Virtual Reality Learning Through Use Of Visual Eye-Tracking Analytics (Veta) And Biological Measurements, Mckinley Anne Sherman Nov 2025

Exploring The Effectiveness Of Virtual Reality Learning Through Use Of Visual Eye-Tracking Analytics (Veta) And Biological Measurements, Mckinley Anne Sherman

Master's Theses

Virtual Reality (VR) offers an immersive and interactive platform for experiential learning. The purpose of this thesis was to evaluate the relationship between physiological responses and cognitive workload within a VR learning environment and to explore VR as an effective instructional tool. This research compared participant engagement, stress, and learning performance within a 6th-grade science module developed in VR by incorporating biometric data collected via Polar H10 heart rate monitor and Varjo Areo VR headset eye-tracking. Thirty-three participants completed a pre-lesson demographic survey, post-lesson survey, VR sickness questionnaire, and the NASA Task Load Index (NASA-TLX). While completing the lesson, the …

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Rethinking Schedule Quality Risk Assessment, Michael E. Oliver, Patrick T. Rodjom Nov 2025

Rethinking Schedule Quality Risk Assessment, Michael E. Oliver, Patrick T. Rodjom

Beyond the Project Horizon: Journal of the Center for Project Management Innovation

Critical Path Method schedule reliability is dependent on exhibition of specific qualities. Failure to exhibit these qualities (i.e., schedule defects) increases project risk exposure. Although current schedule quality assessment methods provide diagnostic remediation insights, they do not provide a meaningful singular assessment value that characterizes the nature and magnitude of schedule quality risk nor do they enable parity when comparing schedule quality across multiple schedules of disparate size (e.g., number of tasks) or complexity (e.g., number of concurrent paths, degree of merge bias). This study employed a design science research approach to address current schedule quality assessment practice dilemmas through …

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Reviving Pan-Africanism For The 21st Century: A Framework For Youth-Led Continental Governance Reform, Ugochukwu Mercy Prince-Ifoh Nov 2025

Reviving Pan-Africanism For The 21st Century: A Framework For Youth-Led Continental Governance Reform, Ugochukwu Mercy Prince-Ifoh

Young African Leaders Journal of Development

This paper explores the historical trajectory, current stagnation, and potential revival of PanAfricanism with a strong emphasis on youth leadership as the engine of governance reform across the African continent. By tracing the intellectual and political contributions of renowned leaders such as Kwame Nkrumah, Julius Nyerere, and Thomas Sankara, the study identifies foundational principles of unity, sovereignty, and collective progress. The paper critically evaluates the Agenda 2063 of the African Union (AU), highlighting opportunities and limitations for youth participation. It also conducts a comparative analysis of regional youth governance structures and proposes practical frameworks to institutionalize youth-led reforms. The paper …

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Interpretable Machine Learning Frameworks For Detecting And Characterizing Adaptive Processes In Genomic Data, Md Ruhul Amin Nov 2025

Interpretable Machine Learning Frameworks For Detecting And Characterizing Adaptive Processes In Genomic Data, Md Ruhul Amin

Electronic Theses and Dissertations 2020 - Present

Detecting genomic regions influenced by adaptive processes is fundamental to understanding adaptation and its connection to modern human traits. Traditional summary-statistic and likelihood methods capture only simple evolutionary scenarios, while deep learning models such as convolutional neural networks, though powerful, often lose spatial information and lack interpretability. This dissertation introduces three complementary frameworks that overcome these limitations by integrating interpretable machine learning with spatially structured genomic data. The first framework, T-REx employs tensor decomposition to extract informative features from haplotype alignment images, enabling accurate classification of selective sweeps with classical learning models. The second framework, α-DAWG applies wavelet and curvelet …

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Advances In The Discovery Of Active Natural Products By Large Fragment Cloning, Dandan Zeng, Jiayu Chen, Tianlu Mo Nov 2025

Advances In The Discovery Of Active Natural Products By Large Fragment Cloning, Dandan Zeng, Jiayu Chen, Tianlu Mo

Journal of Food Science and Biotechnology

Active natural products have diverse structures and activities and can be a major source of small molecule drugs.Given the emergence of multi-drug resistant bacteria and superbacteria,there is an urgent need to develop new active natural products.Large fragment cloning has been an important tool for the discovery of active natural products in recent years,and it has demonstrated obvious advantages in obtaining the biosynthetic gene clusters of active natural products.This approach,combined with efficient cluster-targeted screening methods,has significantly accelerated the discovery of active natural products.This review summarizes a wide variety of active natural products.Furthermore,this paper elaborates on the principles and applications of several …

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Preparation And Application Of A Polyclonal Antibody To Chlamydomonas Reinhardtii Rsp 10, Chan Lu, Yuanyuan Zhang, Ye Tao, Zhenchuan Fan, Yanxia Liu Nov 2025

Preparation And Application Of A Polyclonal Antibody To Chlamydomonas Reinhardtii Rsp 10, Chan Lu, Yuanyuan Zhang, Ye Tao, Zhenchuan Fan, Yanxia Liu

Journal of Food Science and Biotechnology

[Objective ] This study aims to explore the cilium assembly of the radial spoke protein RSP 10 and develop a highly specific polyclonal antibody to RSP 10.[Method ] Firstly,the prokaryotic expression vector pMal-C 2X-rsp10 was constructed,and the expression of MBP-labeled RSP 10 was induced in Escherichia coli BL21 (DE3).After the fusion protein was purified,and the MBP label was excised.The obtained protein was used to immunize New Zealand male white rabbits,and the antibody titer in the anti-serum was determined by indirect ELISA.[Result ] The rabbit anti- Chlamydomonas reinhardtii RSP 10 antibody with high specificity and high sensitivity was obtained after purification …

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Fabrication And Antioxidant Property Characterization Of Caffeic Acid Phenethyl Ester-Loaded Nanoparticles, Yaqiong Chen, Yumeng Li, Hui Wu, Hongdong Song, Xiao Guan Nov 2025

Fabrication And Antioxidant Property Characterization Of Caffeic Acid Phenethyl Ester-Loaded Nanoparticles, Yaqiong Chen, Yumeng Li, Hui Wu, Hongdong Song, Xiao Guan

Journal of Food Science and Biotechnology

[Objective ] This study aims to improve the dispersion and utilization of caffeic acid phenethyl ester (CAPE ) in aqueous solutions.[Method ] CAPE-loaded hordein (CAPE-HD ) nanoparticles were constructed via an anti-solvent precipitation method.The physicochemical properties of the nanoparticles were characterized,and the antioxidant properties of the nanoparticles within Caco- 2 cells were investigated.[Result ] The components within the CAPE-HD nanoparticles interacted through non-covalent bonds,such as hydrogen bonding,resulting in an altered state of CAPE upon nanoparticle formation.The CAPE-HD nanoparticles exhibited near-spherical morphology with an average particle size of 193.93 nm,an average polydispersity index (PDI) of 0.26,and average Zeta potential of 14.50 …

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Bacterial Diversity In Milk And Traditionally Fermented Dairy Products In Balin Right Banner, Lijuan Liu, Gaowa Bai, Jinghe Yu, Fang Wang, Youyi Zhang, Li Zhu, Dalai Wuyun Nov 2025

Bacterial Diversity In Milk And Traditionally Fermented Dairy Products In Balin Right Banner, Lijuan Liu, Gaowa Bai, Jinghe Yu, Fang Wang, Youyi Zhang, Li Zhu, Dalai Wuyun

Journal of Food Science and Biotechnology

[Objective ] This study explored the bacterial diversity in milk and traditional fermented dairy products in Balin Right Banner,aiming to lay a foundation for the development and utilization of bacterial resources in the milk and traditional fermented dairy products in this region.[Method ] A total of 32 samples of cow milk,milk tofu,and sour fermentation supernatant of milk tofu were collected from Balin Right Banner,and their bacterial diversity was analyzed by 16S rRNA high-throughput sequencing.[Result ] The diversity and abundance of bacterial communities varied among the milk and traditional fermented dairy products in Balin Right Banner.The dominant bacterial phyla were Firmicutes …

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A Zif- 8 Electrode Immobilizing Enzyme For Detection Of Glucose Solution In Food, Tingmei Ma, Shouxin Tang, Wenpan Shi, Yuchen Ma, Haijun Du Nov 2025

A Zif- 8 Electrode Immobilizing Enzyme For Detection Of Glucose Solution In Food, Tingmei Ma, Shouxin Tang, Wenpan Shi, Yuchen Ma, Haijun Du

Journal of Food Science and Biotechnology

[Objective ] The aim was to construct an electrochemical sensor based on a metal-organic framework-modified electrode for the highly sensitive detection of glucose solution in beverages.[Method ] An electrochemical sensor based on ZIF- 8 composite carbon nanotubes and immobilizing glucose oxidase (GOx ) was prepared by in-situ synthesis and immobilized enzyme technology.The microstructure and morphology of the material were characterized by X-ray diffraction (XRD ),scanning electron microscopy (SEM ),UV-Vis spectroscopy,and infrared spectrometry (IR).The electrochemical performance of the electrode immobilizing enzyme was tested by electrochemical workstation.[Result ] The prepared electrode immobilizing enzyme showed excellent detection performance for glucose solution,with a limit …

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Establishment Of A Molecularly Imprinted Electrochemical Sensor Nh 2-Mwcnts@ 4-Fpba For The Detection Of Epidermal Growth Factor In Dairy Products, Ruyue Zhang, Yiwei Wang, Hongxiu Zeng, Bini Wang, Fuxin Zhang, Zhenquan Huo, Yufang Liu Nov 2025

Establishment Of A Molecularly Imprinted Electrochemical Sensor Nh 2-Mwcnts@ 4-Fpba For The Detection Of Epidermal Growth Factor In Dairy Products, Ruyue Zhang, Yiwei Wang, Hongxiu Zeng, Bini Wang, Fuxin Zhang, Zhenquan Huo, Yufang Liu

Journal of Food Science and Biotechnology

[Objective ] This study aims to develop a rapid and accurate method for detecting epidermal growth factor (EGF ).[Method ] 4-Formylphenylboronic acid (4-FPBA ) was covalently anchored to the surface of aminocarbon nanotubes (NH 2-MWCNTs ) to synthesize nanocomposites (NH 2-MWCNTs@ 4-FPBA ),and NH 2-MWCNTs@ 4-FPBA was modified on a glassy carbon electrode.When EGF was present,4-FPBA captured the EGF template through benzaldehyde,and then the electrode was immersed in pyrrole solution to electropolymerize to form a pyrrole molecularly imprinted layer.Finally,after dissociation and removal of the EGF template in an acidic solution,a three-dimensional cavity complementary to the EGF template was formed.[Result ] …

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Comparison Of The Bioactivities Of Ziziphus Jujuba Polysaccharide And Its Degradation Products, Chunling Zhou, Xiaoyan Huang, Xuan Zheng, Ju Zhang Nov 2025

Comparison Of The Bioactivities Of Ziziphus Jujuba Polysaccharide And Its Degradation Products, Chunling Zhou, Xiaoyan Huang, Xuan Zheng, Ju Zhang

Journal of Food Science and Biotechnology

[Objective ] This study aims to compare Ziziphus jujuba polysaccharide (ZJP) and its degradation products in terms of their chemical composition and bioactivities.[Method ] ZJP was degraded by α-L-rhamnosidase,cellulase,snail enzyme,and trifluoroacetic acid to prepare different degradation products (ZJP-R,ZJP-C,ZJP-S,and ZJP-T ),and the chemical composition and degradation effects were compared.On the basis of in vitro antioxidant and probiotic activities,the in vivo antioxidant,anti-aging,anti-stress,and neuroprotective activities of ZJP and its degradation products were compared with Caenorhabditis elegans as a model system.[Result ] The mass fraction of reducing sugar and average degree of polymerization of ZJP showed significant variations among different degradation treatments.In addition,Sephadex G- …

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Effects Of Α-Amylase Addition On The Characteristics Of Infant Rice Flour, Huihui Liu, Zhiyong Dai, Mengyi Li, Jiao Peng, Xing Meng, Luyan Liao, Rongbin Zhang Nov 2025

Effects Of Α-Amylase Addition On The Characteristics Of Infant Rice Flour, Huihui Liu, Zhiyong Dai, Mengyi Li, Jiao Peng, Xing Meng, Luyan Liao, Rongbin Zhang

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the effects of α-amylase addition on the characteristics of infant rice flour.[Method ] Infant rice flour samples with different α-amylase addition were prepared.The basic composition,relative molecular mass of starch,gelatinization properties,hydration properties,texture properties,in vitro digestion characteristics,and microstructure of infant rice flour were determined.Furthermore,the correlations between the physicochemical characteristics and quality characteristics of infant rice flour were analyzed.[Result ] The weight-averaged molecular weight and the number-averaged molecular weight of starch in infant rice flour decreased with the increase in α-amylase addition.The gelatinization curve of infant rice flour with α-amylase addition was relatively gentle,and the gelatinization …

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Effects Of Spices On Microbial Community Structure And Volatile Flavor Components Of Fuling Pickled Mustard Tuber, Ting Ren, Yuling Liu, Zhiping Zhao, Xiaoyong Chen, Yumei Peng, Hong Tao, Yuanli Luo Nov 2025

Effects Of Spices On Microbial Community Structure And Volatile Flavor Components Of Fuling Pickled Mustard Tuber, Ting Ren, Yuling Liu, Zhiping Zhao, Xiaoyong Chen, Yumei Peng, Hong Tao, Yuanli Luo

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the effects of spices on the microbial community structure and volatile flavor compounds of Fuling pickled mustard tuber and explore the correlations between dominant microbial genera and volatile components.[Method ] The effects of spices on microbial community structure and volatile flavor components of Fuling pickled mustard tuber were investigated by high-throughput sequencing and headspace solid-phase microextraction (HS-SPME ) coupled with gas chromatography-mass spectrometry (GC-MS ).Pearson correlation coefficients were calculated to reveal the correlations between dominant microbial genera and volatile components.The mass fractions of total acids,nitrite,and reducing sugar were determined.[Result ] The dominant microbial …

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Effects And Mechanisms Of Phytosterol-Oil Bodies Emulsion On Lipid Metabolism Of Caenorhabditis Elegans, Jie Sun, Mengyuan Yuan, Yifei Liu, Fuyao Zhang, Zhuofan Yang, Guoyou Yin Nov 2025

Effects And Mechanisms Of Phytosterol-Oil Bodies Emulsion On Lipid Metabolism Of Caenorhabditis Elegans, Jie Sun, Mengyuan Yuan, Yifei Liu, Fuyao Zhang, Zhuofan Yang, Guoyou Yin

Journal of Food Science and Biotechnology

[Objective ] This study aims to explore the lipid-lowering effects of the phytosterol-oil bodies emulsion (POE ).[Method ] Caenorhabditis elegans was taken as a model to evaluate the effects of POE on lipid metabolism,physiological indexes,and expression of genes associated with oxidative stress and fat metabolism.[Result ] Compared with the control group,different mass concentrations of POE reduced the mass fraction of fat (P<0.01) and the relative content of triglycerides (P<0.05),without toxicity to the growth and development of C.elegans (P<0.01).At the same time,it significantly reduced the level of reactive oxygen species and increased the levels of antioxidant enzymes.In addition,POE affected the expression levels of genes related to fat metabolism.qPCR results showed that POE up-regulated the mRNA level of sbp-1,while down-regulating the mRNA levels of fat-2,nhr-80,and fat-5 (P<0.05).[Conclusion ] POE may improve lipid metabolism by slowing fat deposition,regulating the fat peroxidation pathway,and alleviating oxidative stress in C.elegans.

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Optimization Of The Fermentation Medium Of Aneurinibacillus Jxn- 1 For Caproic Acid Production, Guangdong Gan, Chunlin Zhang, Ting Huang, Junjun He, Chun Pu, Wei Shi, Mingye Peng, Tengfei Zhao Nov 2025

Optimization Of The Fermentation Medium Of Aneurinibacillus Jxn- 1 For Caproic Acid Production, Guangdong Gan, Chunlin Zhang, Ting Huang, Junjun He, Chun Pu, Wei Shi, Mingye Peng, Tengfei Zhao

Journal of Food Science and Biotechnology

[Objective ] This study aims to increase the caproic acid yield of Aneurinibacillus JXN- 1.[Method ] First,a Plackett-Burman design was employed to screen the significant factors affecting caproic acid yield from eight medium components.Subsequently,the path of steepest ascent method was used to determine the optimal concentration ranges of these significant factors.Finally,a Box-Behnken design was utilized to establish a quadratic polynomial regression model,and the interactions among the significant factors were analyzed to predict the optimal medium composition.[Result ] The Plackett-Burman design identified the mass concentration s of sodium acetate and calcium folinate and the volume fraction of ethanol as significant influencing …

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Decoding The Future: African Parliaments, The 4ir, And The Ai Revolution, Bravin Onditi, Immanuel Mwendwa Kiilu Nov 2025

Decoding The Future: African Parliaments, The 4ir, And The Ai Revolution, Bravin Onditi, Immanuel Mwendwa Kiilu

Young African Leaders Journal of Development

The Fourth Industrial Revolution (41R), propelled by advancements in Artificial Intelligence (AI), is ushering in a profound transformation across Africa's economies, governance systems, and societies. For African parliaments, there is an incredible challenge on the governance front, but the opportunities are unprecedented. This paper examines the range of biases, data insecurities, and inequalities the democracies of the continent face, while detailing how African legislatures can instate frameworks to govern and design AI function within the democracies of the continent. As seen in the examples of Rwanda, Kenya, South Africa, and Nigeria, this paper outlines the disparity between the astounding rates …

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An Investigative Analysis Of How African Youth Can Drive Economic Integration By Taking Up Agriculture As A Means Of Economic Livelihood, Gerald Kihara Muchiri Nov 2025

An Investigative Analysis Of How African Youth Can Drive Economic Integration By Taking Up Agriculture As A Means Of Economic Livelihood, Gerald Kihara Muchiri

Young African Leaders Journal of Development

The paper explores how African youth can drive economic integration by using agriculture as an economic means of livelihood. Despite being Africa's most vital asset, African youth remain underrepresented in continental development initiatives and continue to stagnate as they face structural challenges such as perennial unemployment. The recent promulgation of the African Continental Free Trade Area and the Comprehensive Africa Agricultural Development Programme hold immense promise to improve the lives of millions of African youths if leveraged appropriately. This paper concludes that Africa's youth could be the continent's engine to propel sustainable economic growth if their potential is harnessed appropriately, …

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Coup-Proofing As A Tool For Authoritarian Survival In Central Africa: A Comparative Study Of Teodoro Obiang In Equatorial Guinea And Paul Biya In Cameroon, Prince Ifoh Nov 2025

Coup-Proofing As A Tool For Authoritarian Survival In Central Africa: A Comparative Study Of Teodoro Obiang In Equatorial Guinea And Paul Biya In Cameroon, Prince Ifoh

Young African Leaders Journal of Development

For many African leaders, the most serious threat to their rule does not come from elections or public protests but from the people closest to them—the military and ruling elites. This paper examines how Teodoro Obiang Nguema of Equatorial Guinea and Paul Biya of Cameroon have remained in power for more than four decades by carefully reshaping their security institutions in ways that minimize coup risks. Drawing on established theories of authoritarian survival and a comparative analysis of both regimes, the research shows that they rely on a deliberate set of coup-proofing tactics, including the placement of trusted allies in …

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Robotics In Agriculture: Challenges And Opportunities For Net-Zero – A Case For Africa, Oluwafemi Royal Aliu Nov 2025

Robotics In Agriculture: Challenges And Opportunities For Net-Zero – A Case For Africa, Oluwafemi Royal Aliu

Young African Leaders Journal of Development

Evidence of robotics and artificial intelligence (AI) are set to reposition the practice and process of agriculture. This study addressed vital issues in agriculture such as the need for a 70% increase in food production by 2050 because of population growth, technology, and other issues sweeping human livelihood, and are challenges of food insecurity which is currently affecting more than 820 million people globally. Emphasis was placed on the potential of robotics and artificial intelligence (AI) in curbing agricultural challenges in facts such as climate change, water scarcity, and pest management. The study identifies collaboration between different fields such as …

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Inverse Design For Generating Initial Conditions In Scientific Simulations, Leslie Horace, Christin Whitton, Vanessa Job, William Jones, Nathan A. Debardeleben Nov 2025

Inverse Design For Generating Initial Conditions In Scientific Simulations, Leslie Horace, Christin Whitton, Vanessa Job, William Jones, Nathan A. Debardeleben

Computing Sciences

We propose a conditional normalizing flow (CNF) surrogate model to solve generative, many-to-one inverse problems in scientific simulations governed by partial differential equations (PDEs) with time-evolving interactions between heterogeneous materials. We present two case studies: electrostatic potential and heat diffusion, which serve as proxy simulations for generating diverse sets of initial conditions that can reproduce an observed output state (transient or steady). Finally, we provide a comprehensive overview of the synthetic datasets, the model specification, each stage of the experimental workflow, evaluation of training performance, and uncertainty quantification for the generated samples.

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Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3, Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner Nov 2025

Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3, Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner

2020-Current year OA Pubs

Genomic studies of neurodevelopmental disorders (NDDs) have identified several relevant genomic variants. EBF3 is a gene with an excess of protein-coding de novo variants and underlies Hypotonia, Ataxia, and Delayed Development Syndrome. We previously identified noncoding de novo variants in an enhancer of EBF3 and further found enrichment of deletions of this enhancer in NDDs. In this study, we generated a novel mouse line that deletes the highly conserved, orthologous mouse region within the Rr169617 regulatory region, and characterized the molecular and phenotypic aspects of this mouse model. We found a deviation from Mendelian expectation (P=0.02) with significant depletion of …

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A Magnesium Alloy With High Corrosion Resistance, Hardness And Elastic Modulus Enabled By Elemental Synergy, Alexander Helmer, Manoj V. Mugale, Tushar Borkar, Rajeev K. Gupta Nov 2025

A Magnesium Alloy With High Corrosion Resistance, Hardness And Elastic Modulus Enabled By Elemental Synergy, Alexander Helmer, Manoj V. Mugale, Tushar Borkar, Rajeev K. Gupta

Mechanical Engineering Faculty Publications

A magnesium alloy containing Ca, Ti, Zn, and In was synthesized via high-energy ball milling of elemental powders followed by spark plasma sintering. X-ray diffraction and scanning electron microscopy revealed a homogeneous matrix with dispersed Mg-rich phases and intermetallics. Potentiodynamic polarization tests revealed low corrosion current density (9.6 f 2.1 mu A/cm2), a noble corrosion potential (-1197 f 4 mVSCE), and a clear passive region, indicating excellent corrosion resistance. Nanoindentation tests showed high hardness (2.61 f 0.21 GPa) and elastic modulus (55.35 f 5.47 GPa), exceeding those of commercial Mg alloys.

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Connected-Component Labeling Using Hls For High-Energy Particle Physics Instruments, Nick Song, Marion Sudvarg, Roger Chamberlain Nov 2025

Connected-Component Labeling Using Hls For High-Energy Particle Physics Instruments, Nick Song, Marion Sudvarg, Roger Chamberlain

Computer Science Faculty Research & Creative Works

Many instruments used in high-energy particle physics observations, e.g., gamma-ray telescopes, use FPGAs for front-end signal processing of raw sensor data. The use of high-level synthesis (HLS) to express the signal processing algorithms has the potential to significantly reduce development time for new instruments of this type. We describe our experience with one of the computational stages in the signal processing pipeline, island detection, exploring its implementation across multiple configurations: 1D versus 2D islands, and 4-way versus 8-way connected-component labeling (CCL) in the 2D configuration. We report resource usage and performance for both configurations of 2D island detection, including the …

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Modular Architecture For High-Performance And Low Overhead Data Transfers, Rasman Mubtasim Swargo, Engin Arslan, Md Arifuzzaman Nov 2025

Modular Architecture For High-Performance And Low Overhead Data Transfers, Rasman Mubtasim Swargo, Engin Arslan, Md Arifuzzaman

Computer Science Faculty Research & Creative Works

High-performance applications necessitate rapid and dependable transfer of massive datasets across geographically dispersed locations. Traditional file transfer tools often suffer from resource underutilization and instability due to fixed configurations or monolithic optimization methods. We propose AutoMDT, a novel Modular Data Transfer Architecture, to address these issues by employing a deep reinforcement learning agent to simultaneously optimize concurrency levels for read, network, and write operations. This solution incorporates a lightweight network-system simulator, enabling offline training of a Proximal Policy Optimization (PPO) agent in approximately 45 minutes on average, thereby overcoming the impracticality of lengthy online training in production networks. AutoMDT's modular …

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The Transitional Human Being: Literary, Journalistic, And Cinematographic Representations Of The Twentieth- And The Twenty-First-Centuries Italy, Ron Kubati Nov 2025

The Transitional Human Being: Literary, Journalistic, And Cinematographic Representations Of The Twentieth- And The Twenty-First-Centuries Italy, Ron Kubati

Purdue Studies in Romance Literatures

This book analyzes the crisis of the idea of human being based on timeless notions, in the Euroamerican context, as seen primarily through literature and cinema. It focuses on Italy, which has been and remains a crossroads for diverse cultural and political currents—open to Mediterranean cultural influences while remaining within a typically Western cultural context. The “new man,” defined by Corrado Alvaro during his trip in Russia in 1934 as “transitional,” implies a human being with a fundamental need for change. Instead of the “new man,” Italo Calvino in the 1960 preface to his I nostri antenati wrote about the …

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Modeling And Optimizing Real-Time Telescope Interaction For Multi-Wavelength Observation Of Gamma-Ray Bursts, Ye Htet, Marion Sudvarg, Honghao Yang, Jeremy Buhler, Roger Chamberlain, James Buckley Nov 2025

Modeling And Optimizing Real-Time Telescope Interaction For Multi-Wavelength Observation Of Gamma-Ray Bursts, Ye Htet, Marion Sudvarg, Honghao Yang, Jeremy Buhler, Roger Chamberlain, James Buckley

Computer Science Faculty Research & Creative Works

Multi-wavelength observation of gamma-ray bursts (GRBs) requires real-time interaction among multiple telescopes. A gamma-ray telescope detects and localizes a GRB in the sky and must then communicate with an optical telescope to direct the latter toward the GRB as quickly as possible. We previously developed software for ADAPT, a suborbital gamma-ray telescope, to localize GRBs in real time, on a timescale shorter than that of the GRB itself. This work therefore studies progressive localization, in which ADAPT computes a series of increasingly accurate location estimates during a GRB to enable a partner instrument to more rapidly find it. We describe …

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