Digital Commons Network^™

Gboost-Ctl: A Novel Method In Multi-Tissue Transcriptome-Wide Associations Studies In Cross-Tissue Learner Incorporating Gwas Information, Md Mutasim Billah, Hairong Wei, Fengzhu Sun, Kui Zhang

Michigan Tech Publications

Genome-wide association studies (GWAS) have uncovered numerous genetic variants linked to complex human diseases, yet linking these variants to transcripts and tissues that drive pathology remains difficult. Multi-tissue transcriptome-wide association studies (TWAS) offer a powerful bridge, but existing analytical methods have some limitations, either by discarding important signals by separately analyzing and then aggregating results across tissues, implying imputation models in individual tissues, or fusing them with weights that ignore how much GWAS signal each tissue actually carries. Therefore, most of the existing methods do not work uniformly across different GWAS cohorts. Here, we propose GBoost-CTL - a GWAS-boosted cross-tissue …

Divergent Prefrontal Cortex Circuits Regulate Cued Food Seeking Under Distinct Metabolic Or Emotional States, Xu O Zhang, Guillermo Aquino-Miranda, Claire E Cho, Yongzhe Wang, Duy Hoang Ha, Nikita Elinson-Watson, Allen Dong, Caleb Kemere, Fabricio H Do-Monte

Faculty, Staff and Student Publications

Flexibly adjusting food-seeking behaviour in response to food-associated cues and internal states is crucial for animals' survival. However, the neural mechanisms that modulate cued food-seeking behaviour during varying metabolic (i.e., hungry vs. satiated) and emotional (i.e., safe vs. threatened) states remain elusive. Here, we show that the encoding of metabolic or threat states in projection-defined neurons in the prelimbic cortex (PL) mediates cued food-seeking responses in rats. Using microendoscopic imaging, we demonstrate that neural population dynamics in PL consistently represent food cues, task-relevant behaviours, and internal state changes by recruiting distinct subsets of cue-responsive neurons at each state. Single-unit recording …

Field Canals Improvement Projects Duration Prediction: A Comparative Analysis Of Machine Learning Models, Hania Ghouse, Ukaegbu Chinonso Ishmael, Edgar Dario Obando-Paredes, Hashem Shafik Shakir, Ali Al-Bayaty

Electrical and Computer Engineering Faculty Publications and Presentations

There are several essential elements in project construction management to be studied appropriately, and priority to these elements, such as cost and duration, is predominantly interesting to be investigated. In this research, the duration of field canal improvement projects (DFCIP) was predicted using two relatively new machine learning (ML) models - the Multivariate Adaptive Regression Spline (MARS) and Extreme Learning Machine (ELM). The targeted DFCIP was calculated using other dependent parameters, such as the length of the pipe, years of construction, the geographical zone of the network, the supplied area with water, and finally the actual cost of the field …

Harnessing Hyperspectral Imaging And Deep Learning For Terrestrial Habitat Mapping In Arid Landscapes: A Case Study In Saudi Arabia, Ali Elgendy, Hesham Morgan, Brandon Tran, Rejoice Thomas, Tamer Ismail, Yehya Kh. Shehadeh, Ahmed Elgharib, Ahmed Abdullah Al-Dughairi, Ali El Muburak, Khaled Allam Harhash, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

Arid ecosystems remain under-mapped at actionable scales despite their ecological importance. Decision makers lack reliable, high-resolution habitat maps in drylands to prioritize protection and target restoration. This research integrates spaceborne hyperspectral imaging from the Environmental Mapping and Analysis Program (EnMAP) with deep learning semantic segmentation models to produce an updated level of habitat classification based on the International Union for Conservation of Nature (IUCN) for part of the Imam Turki bin Abdullah Royal Reserve, Saudi Arabia. Using ground control points and the full EnMAP spectral cube without band selection, U-Net and DeepLabV3+ architectures were each implemented with VGG19 and ResNet-101 …

Yolo-Based Marine Search And Rescue Using Uav Multi-Dataset In Challenging Weather Conditions, Aysha Alshebli

Thesis/ Dissertation Defenses

Object detection models, powered by deep learning and computer vision, are revolutionizing marine search and rescue (SAR). By analyzing aerial imagery and live drone footage, these systems automatically identify critical targets like survivors, life rafts, and debris across vast and treacherous ocean areas. This capability enhances operational efficiency by reducing human workload and accelerating response times, even in challenging conditions such as poor light, high seas, or cluttered backgrounds. The result is continuous monitoring, faster decision-making, and a significantly improved probability of successful rescue.

Departing from prior methodologies, YOLO introduced a paradigm shift through its single-shot architecture, which concurrently predicts …

Investigate The Performance And Airtightness Of Short Carbon Fiber Reinforced Polypropylene Pressure Vessel Fabricated Via Fdm 3d Printing, Trad Abdallah Abualbandora

Thesis/ Dissertation Defenses

This work offers a thorough investigation into the performance of 3D-printed, short carbon fiber-reinforced polypropylene pressure vessels, specifically designed for gas storage in demanding sectors like aerospace, drones, and medical equipment, operating within a pressure range of 0-10 bar. A key challenge in FDM additive manufacturing of pressure vessels is achieving airtightness due to the inherent porosity and micro-gaps resulting from the printing process. To address this, the fabricated vessel models were coated with various commercially available materials to effectively fill these microscopic imperfections and ensure the necessary tightness. Spray coating and adhesion coating materials were applied to the outer …

Computer Problems? Must Have Been The Sun How Solar Particles And Cosmic Rays Affect The Future Of Computing, Ned Markham

Osmosis Magazine

Imagine playing your favorite video game, when suddenly, your character teleports to the top of the level. One may be quick to blame the software for faulty code, clueless that this error may have originated from an unlikely source: the sun. That’s right, during a speed run of Nintendo’s Super Mario 64, one stray cosmic ray flipped a single bit (a bit is the most basic unit of information inside a computer, storing one of only two possible values of 0 and 1), causing a streamer’s character to glitch in front of him and a live audience. This phenomenon, however, …

A Journey Into The Mysterious Quantum Realm, Kien Bui

Osmosis Magazine

Toward the end of the 18th century, many scientists believed that all the fundamental laws of physics had already been discovered. Falling apples obeyed Newton’s laws of motion, spinning compasses were explained by Maxwell’s unification of electricity and magnetism, and steam engines drove the first industrial revolution through the rise of thermodynamics. Lord Kelvin stated, “[t]here is nothing new to be discovered in physics now, all that remains is more and more precise measurement.” Only “two small clouds,” he warned, were the two remaining mysteries: black-body radiation and the theory of light. These small clouds, however, turned out to be …

My Roman Empire: The Mystery Of Roman Concrete, Lilly Cashen

Osmosis Magazine

After the fall of an empire and millennia of conflict and decay, most structures crumble. Yet the monumental dome of the Pantheon, the towering ruins of the Colosseum, and the sprawling miles of aqueducts still stand today, two thousand years later, as testaments to Roman engineering brilliance. The survival of these ancient structures was made possible by one of Rome’s greatest innovations: Roman concrete, or opus caementicium.

Stem Cells: Potent Potential For Disease Treatment, Natalie Small

Osmosis Magazine

Different cells in the body serve a variety of functions. Cardiac muscle cells contract to pump blood through the heart. Nerve cells transmit electrical and chemical signals throughout the body. Lymphocytes play a role in the immune system to fight infections (Mostafa, 2022). But how do these different cell types arise? The answer is a special type of cell: stem cells.

The Math That Keeps Your Money Safe: Why A Few Extra Characters Could Save You, Joanna Petridi

Osmosis Magazine

Imagine a cracker (yes—that is what malicious hackers are named) sitting behind a screen. Their computer is trying millions of password combinations every minute. Your bank account password, just eight characters long, is the only thing standing between them and your savings. The difference between a password that takes a week to crack and one that would take longer than the universe has existed isn’t magic or luck. It’s simply math.

Osmosis.

Osmosis Magazine

Science Magazine

Coe Presents: Puerto Rico, College Of Engineering

International Education Week

A vibrant event celebrating Puerto Rican culture through snacks, music, and interactive experiences that capture the island’s energy.

Notes For Contributors, Editors Space And Defense

Space and Defense

No abstract provided.

Review Article: International Relations: State Of The Field. Paul R. Viotti’S Kenneth Waltz: An Intellectual Biography (Ny: Columbia University Press, 2023)., Damon Coletta

Space and Defense

In this review essay, Damon Coletta examines Paul R. Viotti’s Kenneth Waltz: An Intellectual Biography (Columbia University Press, 2023), positioning it as both a tribute to and a reexamination of one of International Relations’ most influential theorists. Viotti, a former student of Waltz, reconstructs the intellectual development of structural realism—tracing its philosophical and methodological roots from Man, the State, and War (1959) to Theory of International Politics (1979)—while situating Waltz’s scholarship within the geopolitical and academic transformations of the Cold War era. Coletta highlights Viotti’s skillful balance between biography and disciplinary analysis, showing how Waltz’s systemic approach to international politics …

Review Article: Monetary Power And National Security. A 10th Anniversary Review Of Paul R. Viotti’S The Dollar And National Security: The Monetary Component Of Hard Power (Stanford, Ca: Stanford University Press, 2014), Ricardo Crespo

Space and Defense

In this ten-year retrospective, Ricardo A. Crespo reassesses Paul R. Viotti’s The Dollar and National Security (2014) as a foundational text bridging the fields of monetary policy and national security. Viotti’s central thesis—that military power ultimately depends on a stable and privileged monetary foundation—has only grown more relevant amid today’s weaponization of finance and the geopolitics of sanctions. Crespo highlights Viotti’s argument that sustaining the U.S. dollar’s global dominance requires cooperative security and international consensus, noting how historical parallels—from the sterling gold standard to Bretton Woods—illustrate the fragility of monetary hegemony under fiscal mismanagement or political fragmentation. The review situates …

Plan To Fail By Failing To Plan: Deterring Prc Nuclear Force Expansion, Mark Tang, Grace Buettner

Space and Defense

This article argues that the United States must adapt its nuclear deterrence strategy to counter the People’s Republic of China’s (PRC) accelerating nuclear force expansion. As Beijing seeks to achieve nuclear parity with Washington—projecting up to 1,500 warheads by 2035—the authors contend that U.S. strategy must evolve from Cold War-era models to meet the Indo-Pacific’s unique strategic challenges. They propose the establishment of a Pacific Air Forces (PACAF) A-10 Strategic Deterrence and Nuclear Integration Division, modeled after its European counterpart, to enhance regional nuclear planning, integration, and allied assurance. The paper emphasizes the concept of escalation domination, arguing …

Earth’S Orbital Prison: Codifying Customary Law To Prevent Environmental Catastrophe In Space, Jacob Cook

Space and Defense

This article argues that the accelerating proliferation of space debris in low Earth orbit (LEO) poses an existential threat to the sustainability of the orbital environment—one comparable in strategic gravity to nuclear deterrence during the Cold War. Drawing on liberal internationalist theory and the concept of Mutually Assured Destruction (MAD), the paper asserts that deliberate satellite destruction through anti-satellite (ASAT) testing and negligent debris generation risk triggering a self-sustaining cascade of collisions known as the Kessler Syndrome. Existing treaties, including the Outer Space Treaty and the Artemis Accords, lack enforceable mechanisms to prevent such catastrophic harm. To fill this …

Enabling The Decisive Advantage, Mallory Stewart

Space and Defense

In her keynote address at the 2025 USSPACECOM Legal Conference, former Assistant Secretary of State Mallory Stewart argues that law, norms, and international cooperation are central to maintaining the United States’ “decisive advantage” in outer space. She emphasizes that rules and standards—far from constraining innovation or strategic flexibility—enhance predictability, reduce risk, and empower responsible competition. Stewart highlights the success of initiatives such as the Artemis Accords, the U.S. commitment to forgo destructive direct-ascent anti-satellite (ASAT) tests, and the global expansion of Space Situational Awareness (SSA) agreements as examples of how legal and normative frameworks reinforce stability and collaboration. She …

Space, Law, And National Security, Stephen Whiting

Space and Defense

In his address to the 2025 USSPACECOM Legal Conference, General Stephen Whiting underscores the indispensable role of legal professionals in shaping the future of military space operations and maintaining the rules-based international order in an increasingly contested domain. He outlines the rapid transformation of the space environment driven by commercial innovation, technological proliferation, and the accelerating threat landscape posed by adversaries such as China and Russia. The speech highlights U.S. Space Command’s three “moral responsibilities”: ensuring the delivery of space capabilities to the joint force and allies, protecting and defending critical space assets, and safeguarding the joint force from space-enabled …

Allied Abandonment And Nuclear Proliferation: Lessons From South Korea’S Secret Nuclear Program, Joseph W. Brown

Space and Defense

This article examines South Korea’s clandestine nuclear weapons program of the 1970s as a historical case study for understanding how perceptions of allied abandonment can drive nuclear proliferation. Drawing on alliance theory and archival evidence, the paper situates Seoul’s nuclear ambitions within the context of U.S. burden-shifting under the Nixon Doctrine, subsequent troop withdrawals, and diplomatic retrenchment across East Asia. Despite the continued U.S. military presence, South Korean leaders interpreted American rhetoric and policy actions as signaling a waning commitment to the alliance, prompting the initiation of a secret weapons program under President Park Chung-hee. The study identifies two enduring …

In Defense Of Space Offense, Alexander R. Kleitz

Space and Defense

This article argues that in the unique physical and operational environment of outer space, offensive operations hold intrinsic advantages over defensive ones. Drawing upon classical military theorists such as Clausewitz and Corbett, the author contends that the traditional dominance of the defensive form of war—rooted in terrestrial conditions—does not extend to celestial conflict. The transparency and remoteness of the space domain neutralize key defensive benefits, such as proximity to supply bases, concealment, and fortified positions, while also diminishing the factors that typically cause terrestrial offensives to culminate. Consequently, space conflict favors the side that seizes and maintains the initiative through …

Raising Public Awareness On Space Themes: Analysis Of Brazilian Space Policy Using Data From Google Trends, Andrea Felippe Cabello, Michele Melo

Space and Defense

This study examines whether Brazil’s national space policy goal of increasing public awareness of space activities has been met, using Google Trends data as a proxy for public interest. While public perception surveys are scarce outside the United States, web-based data provide a cost-effective and timely alternative for gauging public engagement. The authors analyzed two decades (2004–2024) of Brazilian search activity related to space topics, institutions, technologies, companies, and missions. Results show no clear upward trend in public interest, suggesting that Brazil’s stated policy objectives of raising awareness have not yet translated into measurable outcomes. Although searches related to government …

Costly Signals In Space: Increasing Credibility Via Strategic Disclosure, Wendy N. Whitman Cobb

Space and Defense

As space becomes an increasingly vital domain for national security, debates persist about how much secrecy should surround U.S. military space programs. This article argues that the strategic declassification and disclosure of selected space capabilities can strengthen U.S. deterrence by enhancing the credibility of deterrent threats. Drawing from theories of costly signaling and audience costs, the paper introduces strategic disclosure as a novel form of costly signal. Such disclosure imposes bureaucratic and operational costs while exposing capabilities to potential adversary countermeasures—thereby demonstrating resolve and seriousness of intent. In tandem, greater public transparency about space programs cultivates informed domestic audiences capable …

Space And Defense Vol. 16 No. 2 Editor's Note, Damon Coletta

Space and Defense

No abstract provided.

Space And Defense Vol. 16 No. 2 Table Of Contents, Editors Space And Defense

Space and Defense

No abstract provided.

Space And Defense Vol. 16 No. 2 Front Matter, Editors Space And Defense

Space and Defense

No abstract provided.

Space & Defense Volume 16 Issue 2 Fall 2025 (Whole Issue), Editors Space And Defense

Space and Defense

No abstract provided.

Hidrotuango: Understanding The Reach Of Cascading Risk, Juan Guevara, Rob Shields

Fast Capitalism

No abstract provided.

“This Is Not Normal”: The Global Academy’S Resistance To Authoritarianism And Academic Capitalism, Catherine A. Labrenz, Christian Adeleke, Maria Lúcia T. Garcia, Aline Pandolfi, Mara Mattioni, Fabíola Xavier Leal, Marcela Nava

Fast Capitalism

Summary: In the wake of rising authoritarianism and neoliberal retrenchment, academic institutions across the globe are increasingly pressured to suppress dissent, sanitize curricula, and deprioritize justice-based scholarship. Drawing from responses to political repression in Brazil and Argentina, this paper connects present-day U.S. conditions to transnational histories of academic resistance.

Findings: We locate today’s institutional silencing within the broader logics of academic capitalism and authoritarian governance, emphasizing how compliance, rather than critical engagement, is becoming the new normal.

Applications: Drawing on radical traditions of academic and professional resistance from the Americas, we present lessons learned and action steps …