Digital Commons Network^™

Local Government Standing As State Standing, Katharine Cooney, Katherine Mims Crocker

Faculty Scholarship

It is increasingly common, and controversial, for local governments to bring lawsuits as plaintiffs in federal court. Many questions about this practice raise matters that sound in policy. But some, including the issue of standing to sue, also raise issues of constitutional law. How local governments fit into standing rules should reflect how they fit into the U.S. constitutional system more broadly. As the Supreme Court put it in the famous (and infamous) 1907 case Hunter v. City of Pittsburgh, "[m]unicipal corporations are political subdivisions of the State, created as convenient agencies for exercising such of the governmental powers of …

Ai And The Fine Print Disruption Of Copyright, Nancy Kim

Penn State Law Review (2003 - Present)

No abstract provided.

After Amgen: Examining The Supreme Court's Impact On Patents For Therapeutic Antibodies, Noah Pollio

Penn State Law Review (2003 - Present)

No abstract provided.

A Novel Microfluidic Approach To Quantify Pore-Scale Mineral Dissolution In Porous Media, Rafid Musabbir Rahman, Elliott Niemur, Gianluca Blois, Farzan Kazemifar, Myeongsub Kim, Yaofa Li

Faculty Research, Scholarly, and Creative Activity

Mineral dissolution in porous media coupled with single- and/or multi-phase flows is pervasive in natural and engineering systems. Dissolution modifies the physical, hydrological, and geochemical properties of the solid matrix, resulting in a complex coupling between local dissolution rate and pore-scale flow. The work reports a microfluidic approach that includes 2D reactive porous media and advanced pore flow diagnostics for the study of pore-scale dissolution in porous media with unprecedented details. The 2D microfluidic porous media, called micromodels, were fabricated in calcite by combining photolithography and wet etching, which not only offers precise control over the structural and chemical properties, …

Plasma Metabolomic And Proteomic Signatures Of Blood Pressure Management After Bariatric Surgery Among Adolescents, Shudi Pan, Zhenjiang Li, Juan Pablo Lewinger, Jesse A Goodrich, Hongxu Wang, Sarah Rock, Carmen Chen, Todd M Jenkins, Stephanie Sisley, Stephen R Daniels, Douglas I Walker, Max T Aung, Erika Garcia, Rob Mcconnell, Sandrah P Eckel, Michele A La Merrill, Tanya L Alderete, Zhuanghua Chen, Frank D Gilliland, Thomas H Inge, David V Conti, Justin R Ryder, Lida Chatzi

Faculty, Staff and Students Publications

Background: Emerging omics approaches, including metabolomics and proteomics, can be integrated into obesity treatment for better blood pressure management. We tested whether preoperative metabolomic and proteomic profiles predict long-term elevated blood pressure (EBP) changes better than known risk factors in adolescents undergoing bariatric surgery.

Methods: We included 108 participants from the Teen-LABS (Teen-Longitudinal Assessment of Bariatric Surgery). Plasma untargeted metabolomics (via liquid chromatography with high-resolution mass spectrometry) and Olink proteomics were assessed pre surgery. An elastic net model with stability selection was used to identify features predictive of EBP reductions 5 years post surgery. Models including identified metabolites, proteins, and …

Genetic And Environmental Determinants Of Streaming And Aggregation In Myxococcus Xanthus, Trosporsha T. Khan, Patrick Murphy, Jiangguo Zhang, Oleg A. Igoshin, Roy D. Welch

Faculty Research, Scholarly, and Creative Activity

Under starvation conditions, a spot of a few million Myxococcus xanthus cells on agar will migrate inward to form aggregates that mature into dome-shaped fruiting bodies. This migration is thought to occur within structures called ‘streams,’ which are considered crucial for initiating aggregation. The prevailing traffic jam model hypothesizes that intersections of streams cause cell crowding and ‘jamming,’ thereby initiating the process of aggregate formation. However, this hypothesis has not been rigorously tested, in part due to the lack of a standardized, quantifiable definition of streams. To address this gap, we captured time-lapse movies and conducted fluorescent cell tracking experiments …

Bypassing Cisplatin Resistance In Nrf2 Hyperactivated Head And Neck Cancer Through Effective Pi3kinase Targeting, Pedram Yadollahi, Kelli A Mccord, Yang Li, Hussam Dayoub, Kalil Saab, Fonma Essien, Sean Hyslop, Emerald Kan, Kazi M Ahmed, Parker R Kirby, Vasanta Putluri, Chandra Shekar R Ambati, Karthik Reddy Kami Reddy, Patricia Castro, Heath D Skinner, Cristian Coarfa, William K Decker, Abdullah A Osman, Rutulkumar Patel, Jeffrey N Myers, Stephen Y Lai, Nagireddy Putluri, Faye M Johnson, Mitchell J Frederick, William H Hudson, Vlad C Sandulache

Faculty, Staff and Students Publications

Background: For patients with head and neck squamous cell carcinoma (HNSCC), failure of definitive radiation combined with cisplatin nearly universally results in death. Although hyperactivation of the Nrf2 pathway can drive radiation and cisplatin resistance along with suppressed anti-tumor immunity, treatment-refractory HNSCC tumors may retain sensitivity to targeted agents secondary to synergistic lethality with other oncogenic drivers (e.g., NOTCH1 mutations).

Methods: Using state of the science mechanistic, metabolomic and spatial transcriptomic approaches combined with preclinical models of HNSCC, we tested whether a novel PI3K inhibitor, gedatolisib, can bypass hyperactivation of the Nrf2 pathway.

Results: The PI3K pathway is activated in …

Method For Generation And Ex Vivo Expansion Of Genetically Edited Mouse Tregs, Yosef Gilad, Adam M Dean, Yan Xia, Sang Jun Han, David M Lonard, Bert W O'Malley

Faculty, Staff and Students Publications

Regulatory T cells (Tregs) play a crucial role in the immune system, and their dysfunction can lead to the development of autoimmune conditions. In cancer, tumors frequently hijack the immunosuppressive function of Tregs to evade immune responses. Due to their central role in key pathological processes, Tregs have gained increasing attention as promising targets for various clinical applications. However, their relative scarcity (∼5% to 10% of CD4+ T cells) and instability presents a technical challenge for research and therapeutic development. In congenic animal models used to investigate autologous cell transfer-based therapies, this challenge is even greater, as Treg donor animals …

Predictive Factors Of Academic Success During Transition To Undergraduate Studies In Stem Programs In Kansas, Elizabeth L. Butler

Electronic Theses and Dissertations

In tThis dissertation the researcher exploreds the correlations between high school GPA, ACT Math, ACT cComposite scores, and first -semester GPA for first-time freshmen at a mid-sized university in the Midwest. This quantitative correlational study uses multiple regression analysis to discover correlations that may exist between these interval variables. Data for this study was collected through a request to the study site’s oOffice of pPlanning and aAnalysiss at the university and was all archival data at a record level for the students. Data had been collected through the admissions process and was stored in Banner and SLATE, both data management …

The Impact Of Career Development Education In Rural Communities: A Program Evaluation, Hayden S. Austin

Electronic Theses and Dissertations

This study examined the impact of a regional career development education program using a post-test-only, exploratory descriptive design with middle and high school students from rural and urban school districts in West Central Texas. Students who participated in the Career and Education Outreach (CEO) program received four classroom sessions focused on labor market information, high-demand industries, employability skills, and career pathways. The purpose of this research was to explore whether students’ perceptions of the value of career development education differed based on geographic region, economic level, educational level, ethnic composition of the district, and the students’ own demographic characteristics. A …

Community College Student Admissions Experiences, Jeremy D. Loy

Electronic Theses and Dissertations

Community college students have always faced barriers to going to college and getting their degrees. Much of the research centers on the completion of their degrees. The purpose of this qualitative, phenomenological study was to understand the experiences of community college students during enrollment. To understand how community college students experience the enrollment process, the study used phenomenology to hear the experiences of students through semistructured interviews. Findings showed that three broad themes emerged from this research. First, students felt both nervous and uncertain about college, but they also recognized the importance of college to improve their lives. Second, students …

The 4-Day School Week: Impacts On Rural Texas School Districts, Geoffery Bowdoin

Electronic Theses and Dissertations

This study examined how school administrators, teachers, and parents in rural Texas districts view the effects of the 4-day school week. Across Texas, a growing number of districts have adopted shorter calendars to address teacher shortages, boost morale, and manage tight budgets. The goal of this research was to gain a clearer understanding of how this schedule shift influences student performance, district finances, and teacher recruitment and retention. The study followed a qualitative descriptive approach. Data were collected through two means. Semistructured interviews were conducted with 12 school administrators, while 29 teachers and 42 parents completed surveys. Research participants came …

Streams Guidelines: Standards For Technical Reporting In Environmental And Host-Associated Microbiome Studies, Julia M. Kelliher, Chloe Mirzayi, Sarah R. Bordenstein, Aaron Oliver, Christina A. Kellogg, Eneida L. Hatcher, Maureen Berg, Petr Baldrian, Mashael Aljumaah, Cassandra Maria Luz Miller, Christopher Mungall, Vlastimil Novak, Alexis Palucki, Ethan Smith, Nazifa Tabassum, Gregory Bonito, J. Rodney Brister, Patrick S. Chain, Mingfei Chen, Samuel Degregori, Xuefeng Peng, Et. Al.

Faculty Publications

The interdisciplinary nature of microbiome research, coupled with the generation of complex multi-omics data, makes knowledge sharing challenging. The Strengthening the Organization and Reporting of Microbiome Studies (STORMS) guidelines provide a checklist for the reporting of study information, experimental design and analytical methods within a scientific manuscript on human microbiome research. Here, in this Consensus Statement, we present the standards for technical reporting in environmental and host-associated microbiome studies (STREAMS) guidelines. The guidelines expand on STORMS and include 67 items to support the reporting and review of environmental (for example, terrestrial, aquatic, atmospheric and engineered), synthetic and non-human host-associated microbiome …

Extreme Bandgap Recessed-Gate Metal Oxide Semiconductor Heterostructure Field Effect Transistors With Drain Current 0.28 A Mm−1 And Threshold Voltage −1.5 V, Abdullah Al Mamun Mazumder, Abdullah Mamun, Kenneth Stephenson, Kamal Hussain, Tariq Jamil, Grigory Simin, Asif Khan

Faculty Publications

Herein, the first demonstration of hybrid high-k oxide (ZrO2-Al2O3) incorporation into extreme bandgap (EBG) Al_0.87Ga_0.13N/Al_0.64Ga_0.36N metal-oxide-semiconductor heterostructure field-effect transistors (MOSHFETs) is presented, with both planar and recessed-gate designs on the same AlN/sapphire template with a state-of-the-art low contact resistance of 1.4 Ω mm (contact resistivity, ρc ≈ 5.7 × 10−6 Ω cm2). The recessed-gate MOSHFETs achieve a threshold voltage shift of ΔVTH = 5.8 V, highlighting improved channel control. Static output measurements reveal a peak drain current (IDS) of 340 mA mm⁻¹ for the planar …

Computational Study On Protein Docking With Vascular Disease Application, Lohitha Reddy Shanigaram

Master's Theses

This thesis investigates how computational methods can help us understand protein docking and vascular diseases by integrating machine learning. The main goal of this research is to develop a system that can predict whether variants in the SOX17 gene are associated to Pulmonary Arterial Hypertension (PAH), a significant vascular condition. To do this, a dataset of 1,063 SOX17 variants was created using publicly available sources such as ClinVar, gnomAD, LOVD, and Ensembl. The study included cleaning and structuring the dataset, encoding genomic data and training a Random Forest classifier to classify variants as positive, negative, or unknown for disease association. …

Rethinking The Performance Evaluation, Jason C. Crowley

Electronic Theses, Projects, and Dissertations

This paper delves into the complexities of performance evaluations within community college settings, aiming to inform a more effective approach specific to the unique characteristics of staff attracted to this work. Grounded in the understanding of validity in psychometric measurement and management theories, it seeks to identify evaluation criteria that prioritize enhancing the working environment which is known to impact overall organizational performance over traditional results-driven metrics to measure individual staff performance. Key theoretical underpinnings include discussions on validity, highlighting that measuring validity against the underlying goal of the performance evaluation (i.e., increased organizational performance) has been largely ignored in …

Property Management System, Abbas Kurnool

Electronic Theses, Projects, and Dissertations

The real estate industry generates and manages large amounts of data, including tenant information, lease agreements, property maintenance schedules, and financial transactions. Reliance on traditional manual methods often results in inefficiencies, fragmented data, and delays in decision-making. To overcome these challenges, this project presents the design and implementation of a Real Estate Property Management System (REMS) for Future Properties, a company aiming to optimize its operations through digital transformation.

The proposed system is developed on Microsoft Dynamics 365 as the core platform, integrated with the Microsoft Power Platform tools (Power Apps, Power Automate, and Power Pages). This integrated framework provides …

A Comparative-Correlational Study On The Mental Health And Well-Being Of First-Generation Students At A Historically Black College And University, Shedred Jackson

Electronic Theses and Dissertations

The purpose of this study was to investigate the mental health and well-being of first-generation college students (FGCS) in comparison to non-first-generation college students (NFGCS) at a private Historically Black College and University (HBCU) in the Southeast. This study was undertaken to investigate students' mental health and well-being, as well as their use of, access to, and the availability of mental health services. A comparative-correlational research design was employed to collect and analyze the data. The study used a sample size of 388 responses from undergraduate college students enrolled at the private HBCU. Of the 388 students in the sample, …

A Leslie System For A Demographic Simulation: From An Actuarial Point Of View, David Kings

Electronic Theses and Dissertations

This thesis develops a discrete stochastic linear systems interpretation of age–stage demographic evolution grounded in Leslie operators and realized in a discrete-event simulation implemented with salabim. The central claim is that one annual cycle of the simulation constitutes a cone-preserving, stochastic affine transformation on a high- dimensional population state vector indexed by age, sex, marital status, household type, employment, and education, and that the composition of yearly operators yields a random matrix product whose top Lyapunov exponent is the stochastic counterpart of the Perron–Frobenius growth rate (Caswell, 2001; Tuljapurkar, 1997)[1, 2]. The actuarial bridge is constructed by mapping simulated survival …

Complementary Color Laser Illumination For Perceptual Contrast Enhancement In Structurally Colored Samples, Tomoshree Dash

All Theses

Structural color, a phenomenon arising from nanoscale interaction between light and materials, has the potential to unveil biological, chemical, physical, and mechanical characteristics of the sample. It enables direct visualization of the sample by human users with high spatiotemporal resolution. However, its impact is often constrained by challenges in the perceptual differentiation of subtle color variations. This thesis introduces complementary color laser illumination (C²LI) as an imaging technique that enhances color perception of the Human Visual System (HVS) by accessing the psychophysical non-linearities in chromatic color perception. C²LI offers a platform optimized for the HVS by …

The Influence Of High School Art Courses On Graphic Communications Students, Mackenzie Crawford

All Theses

This study examines the influence of high school art courses on students’ pursuing a degree in graphic communications (GC) at Clemson University. The purpose is to explore how prior high school art courses impact students’ major choice, preparedness, and academic success within GC. While creativity is central to the field, limited research addresses how early exposure to art integration shapes students’ readiness for college-level technical and design programs.

Grounded in theories of experiential learning and career development, this study builds upon the research by Moss, Benus, and Tucker (2018), who found that school-based arts programs enhance executive function and academic …

Measurement-Based Dynamic Load Model Parameterization Via A Stacked Long Short-Term Memory - Deep Neural Network, Zach H. Smith

All Theses

Increases in distributed generation and changes to predominate load types in modern power systems are driving the need for updated or newly developed dynamic load models. Accurate load modeling is necessary for transmission planning and operation, post-mortem analysis, and inter-regional transfer studies. The most widely used dynamic load model is the WECC Composite Load (CMLD). The CMLD model is an aggregation of substation impedance, under voltage and frequency controls, dynamic motor loads, and static loads. Parameterizing dynamic load models, especially composite models with high parameter counts like the CMLD, is can be difficult. This work proposes a measurement-based, machine learning …

Digital Solutions For Bridging Language Barriers: Designing And Testing An App For Construction Spanish Safety Communication On Construction Jobsites, Adrian Cappella

All Theses

Language barriers between English-speaking supervisors and Spanish-speaking workers create safety risks on U.S. construction jobsites. Hispanic workers face higher injury and fatality rates, with miscommunication being a major contributing factor. Existing translation tools lack the accuracy, cultural context, and jobsite relevance needed for effective safety communication.

In this study a mobile application with construction-specific safety phrases in English and Spanish was designed and field tested. The research included a literature review, phrase collection and validation with industry experts, application development and design with a computer science collaborator, and usability testing with supervisors and workers. Surveys and field trials measured navigation, …

Process Optimization And Cost Reduction For Cellulose Nanocrystals For Metal Removal From Rendered Fat, Sheikh Abdur Rehman

All Theses

Cellulose nanocrystals (CNCs) coupled with polymers featuring a high density of amine functional groups, such as polyethylenimine (PEI), exhibit significant metal-capturing capabilities. Rendered animal fat has applications in a vast number of industries, with the potential to be used as a feedstock for the biodiesel/renewable diesel industries. Nevertheless, rendered fat samples occasionally contain concentrations of metals/inorganic contaminants above the suitable threshold for use in this application. Thus, a cost-effective solution to remove light metal/inorganic contaminants from rendered fat samples is desirable.

To address this problem, a cellulose nanocrystal coupled with polyethylenimine, i.e., CNC-f-PEI, was developed by previous …

Experimental And Numerical Study On The Influence Of Carbon Fiber Reinforcement On The In-Plane Compressive Properties Of 3d Printed Hexagonal Honeycomb Core Structures, Deon Wallace

All Theses

There is difficulty with numerically replicating the behavior of composite honeycomb core structures numerically due to the trouble of gathering material properties from a hollow structure. Also, complex part geometries and carbon fiber reinforcement strategies can lead to unwanted structural weaknesses and variance in material properties that may not be reflected in numerical analysis when the part is additively manufactured. In this study, edgewise compressive testing is used to characterize the mechanical behavior and performance characteristics of these structures. The experimental results indicate an increase in the Young’s moduli of the honeycomb core structures as carbon fiber concentration increases. However, …

Capillary Imbibition Of Shear-Thinning Xanthan Gum Solutions, Aimee Sayster

All Theses

Capillary rise in confined geometries plays a critical role in numerous natural and industrial processes. While classical models such as the Lucas–Washburn equation accurately describe the dynamics of Newtonian fluids, they fail to capture the complex behavior of shear-thinning, non- Newtonian fluids whose viscosity varies with shear rate. This research investigates the capillary rise dynamics of shear-thinning xanthan gum polymer solutions in capillary tubes. The rheological behavior of each fluid is characterized using the Ellis model, which accounts for shear-thinning effects through three key parameters: zero-shear viscosity μ0, characteristic shear stress τ1/2 and viscosity index α. Experimental data was collected …

Cross-Modal Prompting For Multi-Class Visual Anomaly Localization, Duncan F. Mccain

All Theses

Visual anomaly detection is a technology that uses computer vision to automatically identify defects or irregularities in images, such as cracks, scratches, or discolorations on manufactured products. Unsupervised visual anomaly detection does this without needing examples of those defects during the training process. This "unsupervised" approach is crucial in industries like manufacturing, automotive, electronics, and pharmaceuticals, where ensuring product quality is essential for safety, reliability, and cost efficiency. For instance, it helps spot flaws in circuit boards, fabrics, or medical pills during production lines, preventing faulty items from reaching consumers. By reducing manual inspections, it saves time and resources, benefiting …

Study On The Knock Resistance Offered By Thermally Stratifying Water Injections In A Single Cylinder Spark Ignition Engine, Aditya Datar

All Theses

Stochastic end-gas autoignition in SI engines, commonly called ‘knock’, limits attainable engine efficiencies. Multiple pathways to extend SI engine operation into knock-limited regions have been studied, including direct water injection (DWI). This study employs single-cylinder engine experiments and modeling to investigate the knock resistance offered by compression stroke water injections, which have shown to thermally stratify the cylinder in HCCI. In SI, thermally stratifying injections are expected to forcibly widen the cylinder temperature distribution by preferentially cooling the cylinder periphery. The end-gas is in the cylinder periphery; therefore, a cooler end-gas would result in longer ignition delays, thus providing knock …

Tradespace Exploration For Multiple Collaborative Vehicles, Mrunal Deshmukh

All Theses

Modern military operations demand systems that adapt to uncertain, rapidly changing missions across diverse terrains. Traditional single-platform vehicle design is insufficient for such complexity. This research introduces a hierarchical tradespace exploration framework for designing and evaluating families of heterogeneous ground vehicles under a System-of-Systems (SoS) architecture. The framework treats vehicle design as a co-optimization problem, where a “parent” vehicle (e.g., a Squad Multipurpose Equipment Transport) coordinates specialized “child” vehicles for reconnaissance, amphibious tasks, terrain traversal, and stealth missions. Unlike conventional approaches that optimize vehicles individually, this study emphasizes collaborative performance, resource sharing, and adaptability at the family level. Central to …

Comparison Of The Recent Icrp Occupational Intakes Of Rradionuclides Series To Annual Limits On Intake (Ali) In The United States For Select Radionuclides, Aidan B. Barker

All Theses

Dose coefficients (DCs) and secondary limit values (such as the annual limit on intake [ALI] and derived air concentration [DAC]) are useful and convenient quantities in radiation protection (RP) for estimation of radiological dose and the practical application of dose limits. DCs link radioactivity intake to dose while secondary limit values express a dose limit in terms of the type and extent of exposure. The International Commission on Radiological Protection (ICRP), an international organization which provides guidance and recommendations for RP, calculates, tabulates, and updates DCs following new findings and updated knowledge relevant to dose determination (e.g. improved human biokinetics, …