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P-15 Peptide Enhanced Bone Graft Improves Time To Fusion In Transforaminal Lumbar Interbody Fusion: A Randomized, Controlled, Investigational Device Exemption Study, James S. Harrop, Michael P. Steinmetz, John E. O'Toole, Christopher D Chaput, Rick C. Sasso, K. Brandon Strenge, Greg Maislin, Jeffrey P. Mullin, Thomas B. Freeman, Anthony Guanciale, Howard Lantner, Michael E. Janssen, David G. Schwartz, John M. Small, Wellington K. Hsu, Paul M. Arnold

Department of Neurosurgery Faculty Papers

STUDY DESIGN: Prospective, multicenter, single-blind, randomized, and controlled pivotal study.

OBJECTIVE: Compare time-to-fusion in patients treated with P-15L (PearlMatrix TM P-15 peptide enhanced bone graft) versus local autograft over 24 months and evaluate changes in pain and quality of life at 24 months relative to baseline.

SUMMARY OF BACKGROUND DATA: P-15L, an FDA-designated breakthrough device, is a composite bone graft with P-15, a 15-amino acid polypeptide that promotes cellular adhesion, proliferation, and differentiation to support bone formation.

METHODS: Patients (22-80 y) with degenerative disc disease were randomized to the investigational (P-15L) or control (local autograft) group during single-level transforaminal lumbar …

Amp: Single-Shot Ultra-Wide Fisheye-To-Cubemap Pnp Pose Estimation, Ryan M. Raettig, Richard R. Nyquist, Scott L. Nykl, Clark N. Taylor, Christine M. Schubert Kabban

Faculty Publications

Estimating the position and orientation of a rigid object from an image is critical for situational awareness in robotics and autonomous systems. This study explores relative pose estimation using an ultra-wide fisheye camera for unmanned aircraft inspection vehicles. Ultra-wide fisheye lenses introduce radial distortion and capture features beyond the rectilinear image plane, rendering rectilinear Perspective-n-Point (PnP) algorithms inadequate. Designing a bespoke ultra-wide fisheye localization algorithm requires consideration of both the feature detection method and the pose estimator itself. This study proposes a novel method that combines (1) a fisheye-to-cubemap reprojection, (2) a You Only Look Once (YOLO) convolutional neural network …

Adaptive Neuromodulation Dialogues: Navigating Current Challenges And Emerging Innovations In Neuromodulation System Development, Frederik Lampert, Matthew R Baker, Michael A Jensen, Amir H Ayyoubi, Christian Bentler, Jessica L Bowersock, Rosana Esteller, Jeffrey A Herron, Graham W Johnson, Daryl R Kipke, Christopher K Kovach, Vaclav Kremen, Filip Mivalt, Joseph S Neimat, Theoden I Netoff, Enrico Opri, Alexander Rockhill, Joshua M Rosenow, Kristin K Sellers, Nathan P Staff, Chandra Prakash Swamy, Ashwin Viswanathan, Gerwin Schalk, Timothy Denison, Dora Hermes, Nuri F Ince, Peter Brunner, Gregory A Worrell, Kai J Miller

Faculty, Staff and Students Publications

Adaptive neuromodulation systems and implantable brain-computer interfaces have made notable strides in recent years, translating experimental prototypes into clinical applications and garnering substantial attention from the public. This surge in interest is accompanied by increased scrutiny related to the safety, efficacy, and ethical implications of these systems, all of which must be directly addressed as we introduce new neurotechnologies. In response, we have synthesized the insights resulting from discussions between groups of experts in the field and summarized them into five key domains essential to therapeutic device development: (1) analyzing current landscape of neuromodulation devices and translational platforms (2) identifying …

Integrating Traditional Ecological Knowledge And Environmental Science For Sustainable Lake Conservation: Danu Kerthi In Bali, Ni Kadek Surpi, Si Luh Nyoman Seriadi, Ni Wayan Jemiwi Jero

Journal of Environmental Science and Sustainable Development

This study investigates how the Danu Kerthi philosophy operates as a framework that integrates Traditional Ecological Knowledge (TEK) with environmental science to support sustainable lake conservation in three upstream lakes in Bali: Beratan, Buyan, and Tamblingan. While previous scholarship has largely focused on the normative and symbolic dimensions of Sad Kerthi, empirical evidence on its ecological effectiveness remains limited. To address this gap, the study adopts a multi-site qualitative design involving participatory observation, document analysis, and semi-structured interviews with 30 participants representing traditional leaders, Hindu priests, tourism managers, village officials, and local residents. Thematic analysis shows that Danu Kerthi continues …

Investigate The Role Of Tgfβ3 In Regulating Irf6 And Δnp63 In Periderm Desquamation, Nam Ha

Theses & Dissertations

Introduction: Failure in palatal fusion during palate development results in cleft palate, one of the most common birth defects in the US. During the final phases of palatogenesis, the palatal periderm (a protective cell layer that prevents premature fusion and adhesion with oral epithelium) must be removed, also known as desquamation. This process is a prerequisite for establishing the midline seam in the fused palate. Previous studies have shown that transforming growth factor-β3 (TGFβ3) plays an irreplaceable role in palate development in mice. Our previously published mechanistic models outline the role of TGFβ3 and its downstream signaling cascade involving proteins …

Assessment Of Polymeric Chloroquine Formulations For Targeted Therapy Of Ulcerative Colitis And Metastatic Colorectal Cancer, Neha Kumari

Theses & Dissertations

Effective targeted drug delivery is a critical unmet need in the management of both ulcerative colitis and metastatic colorectal cancer, where conventional systemic therapies may be hindered by suboptimal efficacy and significant side effects. This thesis explores the development and preclinical assessment of polymeric chloroquine (PCQ)-based nanotherapeutics, leveraging stimuli-responsive designs for disease-specific delivery and action.

For ulcerative colitis, a reactive oxygen species (ROS)-responsive nanogel system was engineered to release PCQ, a macromolecular derivative of hydroxychloroquine, specifically in the inflamed areas within the colon. Nanogels with well-defined size and positive surface charge were synthesized via reversible fragmentation chain transfer (RAFT) polymerization …

Role Of Nadph Oxidase 4 In Murine Cancer-Associated Fibroblast, Faith M. Gomez

Theses & Dissertations

Breast cancer is the second leading cause of cancer deaths in women in the United States. Frontline hormone therapies for breast cancer prove ineffective in triple negative breast cancer tumors wherein the hormones estrogen, progesterone, and HER2 are downregulated or absent; therefore, patients diagnosed with triple negative breast cancer are primarily limited to chemotherapies which carry a higher failure and resistance rate. Here we target cancer associated fibroblasts as potential drivers of chemoresistance in triple negative breast cancer. We investigated the mechanism by which Nox4 regulates the YAP/TAZ pathway in modulating DTX sensitivity and sought to determine if targeting Nox4 …

Optimal Sizing Of Battery Energy Storage Systems For Peak Shaving And Demand Response Using A Degradation-Aware Bayesian Optimization-Mixed-Integer Linear Programming Framework, Jiwei Yao, Blake Billings, Tao Gao, John Hedengren, Kody M. Powell

Faculty Publications

The increasing integration of renewable energy and rising electricity demand highlight the importance of battery energy storage systems for peak shaving and demand response. Unlike prior approaches that overlook operational impacts on degradation, this study proposes a Bayesian Optimization–Mixed Integer Linear Programming framework for optimal battery energy storage system sizing. In this framework, Mixed Integer Linear Programming determines short-term scheduling while a calibrated electrochemical model iteratively evaluates degradation. The central hypothesis is that the framework can efficiently identify optimal sizes that yield realistic and economically robust outcomes. The method is tested across three scenarios: peak shaving, peak shaving with energy-reduction …

Socrates And Early Buddhist Medical Ethics: Foundations Of Moral Reasoning In The Care Of Body And Mind, Chandima Gangodawila

Budhi: A Journal of Ideas and Culture

While Buddhist traditions articulate a parallel moral vision in the early discourses of the Pāli Canon, Western traditions usually locate the roots of ethical reasoning in Socratic inquiry. Especially in their approaches to bodily care, spiritual well - being, and moral responsibility, this article contends that both Socratic and Early Buddhist ideas converge on fundamental principles in medical ethics. Through a comparative textual and philosophical study, the paper examines how Socratic dialectics and the Buddha's diagnostic approach to dissatisfa ction/ suffering (dukkha) both produce frameworks for ethical healthcare anchored in the development of virtue, wisdom, and care for the integrity …

Inclusive Stem Education In Nigerian Schools:An Emerging Pathway For Substainable Development, Oginni Aderonke Margaret Dr., Awobodu Victoria Yetunde Dr., Olusegun Bisola Esther Miss

Journal of Educational Research and Practice

Inclusive STEM (science, technology, engineering, and mathematics) education plays a vital role in promoting equitable learning opportunities and fostering sustainable development. However, in Nigeria, many marginalized student groups face barriers that hinder their full participation in STEM fields. This study examines the factors impeding inclusivity in STEM education and their effects on students’ motivation, academic performance, and awareness of sustainable development in Lagos State. Employing a survey research design, data were gathered from 550 students selected through simple random sampling across 21 secondary schools in Education Districts I, III, and V. A researcher-developed questionnaire was used for data collection. To …

Black Women And Latinas In Stem: A Systematic Review Of Literature, Karin Moore

The Scholarship Without Borders Journal

This systematic review of literature examines scholarly studies conducted on Black women and Latinas in STEM fields and in STEM higher education. Women are underrepresented in STEM, and on average they comprise 27% of the STEM population (National Science Foundation, 2017). Black women and Latinas are even further underrepresented in STEM by making up only 14.58 % and 3% of the employees in STEM industries (Hispanic Heritage Foundation, 2020; National Science Foundation, 2021). Barriers for all women are the focus of much of the body of literature in STEM (Beach et al., 2024; Moore, 2024). Isolating specific challenges Black women …

Equity And Effectiveness In Advanced Mathematics Education: A Literature Review Of Ap Calculus, Cambridge Aice, And Ib Curricula, Jinhee Lee

The Scholarship Without Borders Journal

This literature review investigates equity and effectiveness of three globally recognized advanced high school mathematics programs: AP Calculus, Cambridge International Advanced International Certification of Education (AICE) Advanced Level (A-Level) Mathematics, and International Baccalaureate (IB) Mathematics High Level. Access to advanced mathematics is unequally distributed, impacting underprivileged students (Bressoud, 2021). This review examines curriculum content, teaching methods, and assessment strategies in alignment with college admissions, depth of conceptual understanding, inclusion of diverse approaches, and assessment accessibility. Findings will contribute to informed curriculum choices for students and inform equitable practices for educators.

New Irs Procedures For Handling Joint Committee Cases, Donald C. Alexander

Tax Adviser

No abstract provided.

Internet Technology's Impact On Intentional Communities: A Case Study Of Acorn Community, Jade Aguilar

Communal Societies

No abstract provided.

Marie Ogden And The Home Of Truth: A Millennial Prophet And The Life And Decline Of Her Community, Bradley C. Whitsel

Communal Societies

No abstract provided.

The Communal Wanderings Of August Jacobi, Peter Hoehnle

Communal Societies

No abstract provided.

Community Sustainability: The Challenge Of Intergenerational Change, Peter H. Cock

Communal Societies

No abstract provided.

Challenges In Addressing Cyberharassment Of Domestic Violence Victims Within The Council Of Europe Instruments, Gulnaz Alasgarova

Widener Commonwealth Law Review

No abstract provided.

Burden Of Light: The Emissary Of Divine Light Myth System As A Unifying Community Force, Sandy Brown Jensen

Communal Societies

No abstract provided.

Becoming "Two-In-One:" Imaginary Space And Androgyny In Koreshan Universology, Kathryn Turner

Communal Societies

No abstract provided.

“Mud, Mud, Mud To The Right Of Us”: How Canadian Reconnaissance Regiments Adapted To The Terrain Of The Scheldt Estuary, Victoria Sotvedt

Canadian Military History

During the Battle of the Scheldt, Canadian reconnaissance regiments played a crucial role in gathering information for their attached divisions and participating in combat operations. To be effective in this role, these regiments needed to maintain a high level of mobility and be adept at operating at or beyond the divisional front. As First Canadian Army moved into the Scheldt Estuary in autumn 1944, the reconnaissance regiments’ mobility and efficiency were challenged by the difficult terrain. These regiments therefore developed new techniques to allow them to continue fulfilling their role despite these challenges, including the adoption of new weaponry and …

A Clash Of Conflicting Priorities: Why Did The Battle For The Beveland Causeway Last Almost Three Weeks? 7 October - 24 October 1944, Robert W. Catsburg

Canadian Military History

This article examines the 2nd Canadian Division’s nearly three-week campaign to drive German forces from the Beveland Causeway, a key part of the Battle of the Scheldt. Despite having superior numbers, the Canadians—led by Brigadier Holley Keefler—were unable to break through the enemy lines at Woensdrecht. In the secondary literature, high praise is given to the skill of the German battle group, at the expense of Canadian combat effectiveness. Drawing on primary sources, this article highlights the aggravating factors that contributed to this unexpected stalemate. It shows that, independent of the courage and ability of the soldiers on the ground, …

The Clear-Up: The Anglo-American Experience In Southeastern Italy, 1943–1946, Amy Muschamp

Canadian Military History

As Allied forces gradually ascended Italy in the arduous Italian Campaign, the newly liberated country was left in chaos. Focusing on the often-overlooked experiences of Southeastern Italy, and in particular the area known today as the region of Molise, this article presents an analysis of the Allied clear-up operation within this tumultuous situation. The mass movement of people southwards has been described as the “real drama” of the war for those living in Molise and the experiences of the people here are representative of many in the rural south. Moreover, knowledge gained by Allied forces here would impact future operations …

Lieutenant-Colonel Donald Mackenzie And The 48th Highlanders Of Canada: A Study In Battalion Command And Officer Progression, Tyler Wentzell

Canadian Military History

Lieutenant-Colonel Donald Mackenzie was the commanding officer of the 48th Highlanders of Canada from June 1944 until his death in April 1945. He had been a lieutenant in the militia when the war broke out. His chain of command quickly made him a company commander, then sent him away from the unit to gain valuable staff training and experience. Although lacking combat leadership experience, he rejoined the 48th Highlanders in Italy, became the battalion’s second-in-command, and, after only five months, took over as the commanding officer at the age of twenty-nine. Mackenzie’s experience provides valuable insight into the challenges faced …

From The Archives: Bringing Air To The Sea: Four Competing Paths To Developing U.S. Naval Aviation And Their Lessons, Sam J. Tangredi

Naval War College Review

No abstract provided.

Sea Power And The American Interest: From The Civil War To The Great War, Ryan Wadle, John Fass Morton

Naval War College Review

No abstract provided.

Winning Without Fighting: Irregular Warfare And Strategic Competition In The 21st Century, Kevin D. Stringer, Rebecca Patterson

Naval War College Review

No abstract provided.

Sg Radar In The Solomon Islands Campaign—Assumptions, Perceptions, Reality, Leonard R. Heinz

Naval War College Review

Radar made its appearance in Pacific night combat in August 1942, but initial attempts to use the new technology in surface actions proved disappointing, leading to the development of a standardized combat information center organization on warships to gather, synthesize, analyze, and report information to commanders in real time.

Neither Confirm Nor Deny—The U.S. Navy’S Declaratory Policy On Nuclear Weapons, Jeffrey A. Larsen, James J. Wirtz

Naval War College Review

The reintroduction of the submarine-launched nuclear cruise missile into the U.S. Navy’s arsenal signals a shift in U.S. nuclear policy, challenging long-standing declaratory norms and public statements such as the “neither confirm nor deny” stance on the presence of nuclear weapons on warships.

Floating Fortresses—American Carriers’ Extraordinary Resilience To Battle Damage, Walker Gargagliano

Naval War College Review

On the basis of Cold War–era munitions accidents and World War II combat experience, U.S. carriers of today are far more resistant to battle damage than commonly believed.