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Articles 25951 - 25980 of 1105838
Full-Text Articles in Entire DC Network
Synthetic Contact Zones: Meeting Nature And Animals In Video Games, Sarah C. Mcpherson
Synthetic Contact Zones: Meeting Nature And Animals In Video Games, Sarah C. Mcpherson
English Theses
Due to economic and environmental barriers, encounters with animals and nature have become increasingly inaccessible for many people, while video games have emerged as a common site for simulated environmental interaction. This thesis conceptualizes video games as synthetic contact zones, or digital spaces where representations of humans, animals, and environments interact, conflict, and shape one another. Drawing on the theories of Mary Louise Pratt, Donna Haraway, and Alenda Y. Chang, this project analyzes how video games model relationships between players, animals, and ecological systems through interactive mechanics and environmental storytelling. Explorations of Red Dead Redemption 2, Blair Witch, …
Enhancing The User Experience Of Colorado Bend State Park Through The Implementation Of Cultural Landscape Analysis, Hunter C. Lynch
Enhancing The User Experience Of Colorado Bend State Park Through The Implementation Of Cultural Landscape Analysis, Hunter C. Lynch
Landscape Architecture Masters & Design Theses
This design thesis investigates how landscape character and sense of place can be more clearly expressed through a cultural landscape approach to design at Colorado Bend State Park, a state park in Texas, with a focus on guiding future trail and campsite development in the currently undeveloped eastern portion of the park.The park’s dramatic canyons, limestone bluffs, spring-fed systems, and upland prairies form a series of distinct, yet interconnected landscape conditions shaped by the interaction of physical structure, ecological systems, and cultural associations. While these characteristics define the site's identity and are reflected in portions of the existing park, they …
Voice And Student Engagement With Writing: Integrating Perspective, Personality, And Style, Sara S. Martin
Voice And Student Engagement With Writing: Integrating Perspective, Personality, And Style, Sara S. Martin
English Dissertations
The rise of generative AI has many teachers worried about the future of writing classes and students’ desire to learn. However, instructors can motivate students to write by valuing what AI can never replace: their voices. Previous definitions of voice took the concept for granted and left it either vague or reductive, unhelpful for structured lessons. I propose a new, more teachable definition of voice as perspective, personality, and style. Perspective takes priority because it belongs solely to the individual and the unrepeatable moment of composition. Personality infuses passages with emotion, forming a bond between author and reader. Style, the …
Enhancing The Performance Of Disk-Based Key-Value Stores: From Learned Index Acceleration To I/O-Efficient Hybrid Caching, Sujit Maharjan
Enhancing The Performance Of Disk-Based Key-Value Stores: From Learned Index Acceleration To I/O-Efficient Hybrid Caching, Sujit Maharjan
Computer Science and Engineering Dissertations - Archive
The exponential growth of data in modern computing environments has rendered the efficient extraction of information from massive datasets a critical systemic requirement. Key-value (KV) storage systems serve as the backbone for these operations; however, their performance is consistently bottlenecked by two primary functional requirements: identifying the data's location and managing the physical cost of accessing the storage device. Data locations are typically identified via an index, while disk I/O is minimized through caching. This dissertation presents LearnedStore, TurboIndex, and ReadBooster, which break these performance bottlenecks by introducing architectural modifications to the index and cache. LearnedStore accelerates operations by adapting …
Adaptive Synchronization In Digital Twin–Enabled Iot Systems: A Unified Framework For Energy, Fidelity, And Latency Trade-Offs, Uzma Zehra
Computer Science and Engineering Theses
Digital twin technology has emerged as a foundational paradigm for enabling real-time monitoring, analysis, and control in Internet of Things (IoT) systems by maintaining virtual representations of physical processes. Its effectiveness, however, critically depends on timely and accurate synchronization between distributed sensing devices and their corresponding digital counterparts. Frequent synchronization improves reconstruction fidelity and system responsiveness but incurs significant communication energy consumption and network latency. In contrast, infrequent synchronization conserves communication resources but can lead to stale or inaccurate digital twin states, particularly in environments with rapidly changing dynamics. These opposing effects give rise to a fundamental trade-off among energy …
Performance Evaluation Of Modified Moisture Barrier For Subgrade Stabilization Of Pavements On Expansive Soils, Md Tamim Shahriar
Performance Evaluation Of Modified Moisture Barrier For Subgrade Stabilization Of Pavements On Expansive Soils, Md Tamim Shahriar
Civil Engineering Theses
Expansive soils inflict an estimated nine to fifteen billion dollars in annual damage to infrastructure across the United States, surpassing the combined losses from earthquakes, floods, hurricanes, and tornadoes (Nelson and Miller, 1997; Jones and Jefferson, 2012). In Texas, eighteen of twenty-five TxDOT districts contend with pavement failure rooted in moisture-driven volume change of subgrade clay, consuming roughly twenty-five percent of the agency's annual budget for maintenance and repair (Sebesta, 2002; Wanyan et al., 2010). Conventional remediation approaches, including soil replacement, chemical stabilization with lime or cement, and prewetting, are either prohibitively expensive, unsuitable for high-sulfate soils, or confined to …
Ai Literacy Frameworks In Secondary Cte: Supporting The Next Generation Of The Workforce, Reagan Kaylee Montross
Ai Literacy Frameworks In Secondary Cte: Supporting The Next Generation Of The Workforce, Reagan Kaylee Montross
All Electronic Theses and Dissertations
The purpose of this literature review is to understand how generative AI (GenAI) is impacting the future employment of high school students at the forefront of the most significant technological, cultural, and educational shift of this generation. It examines five AI literacy frameworks relating to secondary education. These frameworks each emphasize the importance of educating students in AI literacy and provide educators with a structure for integrating AI skills. Among the frameworks reviewed, those published by the United States Department of Labor and the OECD place greater emphasis on applied practices, while the AI4K12 and KAT frameworks emphasize how AI …
Generative Imaging For Computational Pathology, Md Jillur Rahman Saurav
Generative Imaging For Computational Pathology, Md Jillur Rahman Saurav
Computer Science and Engineering Dissertations
Hematoxylin and eosin (H&E) staining remains central to cancer diagnosis, providing morphological information essential for pathological assessment. Immunohistochemistry (IHC) and newer multiplexed imaging technologies complement H&E by revealing molecular information critical for accurate tumor subtyping and treatment decisions. In practice, however, H&E and IHC are obtained from different consecutive sections that are not spatially aligned, comprehensive multiplexed panels are expensive and tissue-consumptive, and not all stains are available at every clinical site, limiting comprehensive molecular profiling and the full diagnostic potential of these technologies in clinical practice. This dissertation addresses these gaps through three complementary generative deep learning studies in …
Density And Fiber Alignment Of The Fibrous Extracellular Matrix In Ovarian Cancer Metastases, Rachel Glantzberg, Aditi Singh, Mohammad Asghar Qanit
Density And Fiber Alignment Of The Fibrous Extracellular Matrix In Ovarian Cancer Metastases, Rachel Glantzberg, Aditi Singh, Mohammad Asghar Qanit
Wetterhahn Science Symposium Posters
The primary aim of this project is to improve and justify biophotonic approaches to label-free, non-invasive cancer detection, particularly within the context of peritoneal metastases from ovarian cancer. Ovarian cancer often metastasizes to the peritoneum, resulting in microanatomical changes in collagen and elastin fiber direction and density. While prior research has provided insights regarding collagen density changes in other types of cancer, peritoneal metastases from ovarian cancer remain minimally characterized, particularly in regards to elastin fibers. Preliminary results suggest that there is a difference in the elastin and collagen contents of healthy and cancerous tissues and that these contents differ …
Preliminary Observations From The Relativistic Electron Atmospheric Loss (Real) Satellite Mission, Evzen Selvon, Robyn Millan
Preliminary Observations From The Relativistic Electron Atmospheric Loss (Real) Satellite Mission, Evzen Selvon, Robyn Millan
Wetterhahn Science Symposium Posters
The Relativistic Electron Atmospheric Loss (REAL) spacecraft (launched in July 2025) is a 3U cubesat designed to measure the precise energies (1 keV – 2MeV) and pitch angles of electrons entering the Earth’s ionosphere. The mission involves Dartmouth, BU, JHUAPL, MSU, and NASA. REAL carries three particle sensors measuring low, medium, and high energies. This work is focused on the ElectroStatic Analyzer (ESA) instrument, designed to measure lower energy electrons (1-40 keV) in the directions parallel and perpendicular to the Earth’s magnetic field. This research aims to identify notable events observed by the REAL spacecraft for future analysis.
When Machines Collude: Rebooting Antitrust Law For The Age Of Algorithmic Markets, William K. Knight
When Machines Collude: Rebooting Antitrust Law For The Age Of Algorithmic Markets, William K. Knight
Emory Law Journal
Increasingly, our lives are being dominated by algorithms. From social media feeds to credit scoring, algorithms play a major role in our day-to-day lives, whether we recognize it or not. An emerging issue in the modern technology landscape is the potential for algorithms to cause anticompetitive harm to free markets. As pricing algorithms become more advanced and more widespread, they could facilitate collusive arrangements in a manner that bypasses antitrust laws, thereby adversely impacting consumers through higher prices. American competition law, primarily governed by the Sherman Antitrust Act, suffers from glaring deficiencies and ambiguities that remain unresolved, leaving it manifestly …
Predicting Next-Day Eur/Usd Direction Using News Sentiment And Technical Indicators With Finbert And Xgboost, Darshan Sanjaybhai Khunt
Predicting Next-Day Eur/Usd Direction Using News Sentiment And Technical Indicators With Finbert And Xgboost, Darshan Sanjaybhai Khunt
Selected Full-Text Master Theses 2021-
Forecasting exchange-rate movements is a challenging task because currency prices are influenced not only by macroeconomic and financial variables but also by market sentiment reflected in financial news. This thesis examines whether financial news headlines can be used to predict the next-day directional movement of the EUR/USD exchange rate by applying finance-specific natural language processing and machine learning techniques.
The study uses a dataset of approximately 466,000 finance-related English-language news headlines collected between 2021 and 2025, aligned with daily EUR/USD closing prices. After preprocessing and temporal alignment, the data are used to construct a binary classification task in which the …
Co-Encapsulation Of Microalgae Haematococcus Pluvialis And Lactic Acid Bacteria Lacticaseibacillus Casei Via Filamentous Fungi Scaffolds Improved Probiotic Viability In Simulated Gastro-Intestinal Conditions, Suvro Talukdar, Tyler J. Barzee
Co-Encapsulation Of Microalgae Haematococcus Pluvialis And Lactic Acid Bacteria Lacticaseibacillus Casei Via Filamentous Fungi Scaffolds Improved Probiotic Viability In Simulated Gastro-Intestinal Conditions, Suvro Talukdar, Tyler J. Barzee
Biosystems and Agricultural Engineering Faculty Publications
Fungal-assisted cell immobilization has emerged as a promising approach for food, energy and environmental applications, utilizing the hyphal network of filamentous fungi to encapsulate microorganisms. Co-encapsulation of multiple microorganisms within fungal pellets enables the development of food delivery systems that combine complementary functional and nutritional properties, including enhanced probiotic protection and delivery of bioactive compounds. This study used edible filamentous fungus Aspergillus awamori to encapsulate Haematococcus pluvialis microalgae and Lacticaseibacillus casei lactic acid bacteria (LAB) for probiotic delivery. Both active and heat-deactivated pellets successfully co-encapsulated microalgae and LAB, although low shear conditions were required for inactive fungal states. Under in-vitro …
Exploring Relational Farming Futures For Responsible Innovation In Precision Agriculture Through Q-Method And Speculative Design, Bhavna Joshi, Maaz Gardezi, Edward Prutzer, Awais Hameed Khan, Asim Zia, Benjamin E. K. Ryan, Ali Dadkhah, Donna M. Rizzo, John T. Mcmaine, David Clay
Exploring Relational Farming Futures For Responsible Innovation In Precision Agriculture Through Q-Method And Speculative Design, Bhavna Joshi, Maaz Gardezi, Edward Prutzer, Awais Hameed Khan, Asim Zia, Benjamin E. K. Ryan, Ali Dadkhah, Donna M. Rizzo, John T. Mcmaine, David Clay
Biosystems and Agricultural Engineering Faculty Publications
This article draws on concepts of speculative design and responsible innovation to examine the possible impacts of data-driven precision agriculture on farmers and farm work. We use an innovative mixed-method approach to research design. Using artistic depiction of futures of precision agriculture in design workshop and in-depth semistructured interviews conducted with the farmers in Vermont and South Dakota, we explain how farmers perceive different futures of precision agriculture. Specifically, in our design workshop, we combined visual arts and social science methods, namely Q-method, to explore existing and new relationships between humans, technologies, and environment in the design, deployment, and use …
Improving Data Collection And Analysis For Development Of An Ai Powered Video Based Autism Screening Tool, Angelica Sanyal, Ziteng Wang
Improving Data Collection And Analysis For Development Of An Ai Powered Video Based Autism Screening Tool, Angelica Sanyal, Ziteng Wang
CURE Proceedings
No abstract provided.
Dim Light At Night Impacts Circadian Rhythms And Alzheimer’S Disease-Like Neuroinf Lammation And Neuropathology In Humanized App Saa Knock-In Mice, Marilyn J. Duncan, Margaret R. Hawkins, Leke Bytyqi, Haleigh R. Whitlock, Savannah M. Shepard, Makayla F. Cox, Esther G. Drinkard, Teresa Macheda, Kelly N. Roberts, Katharina Kohler, Mary-Claire Schmidt, Carrie E. Johnson, Sridhar Sunderam, Bruce F. O'Hara, Michael Paul Murphy, Adam D. Bachstetter
Dim Light At Night Impacts Circadian Rhythms And Alzheimer’S Disease-Like Neuroinf Lammation And Neuropathology In Humanized App Saa Knock-In Mice, Marilyn J. Duncan, Margaret R. Hawkins, Leke Bytyqi, Haleigh R. Whitlock, Savannah M. Shepard, Makayla F. Cox, Esther G. Drinkard, Teresa Macheda, Kelly N. Roberts, Katharina Kohler, Mary-Claire Schmidt, Carrie E. Johnson, Sridhar Sunderam, Bruce F. O'Hara, Michael Paul Murphy, Adam D. Bachstetter
Neuroscience Faculty Publications
Artificial light at night (light pollution) is widespread but understudied in the context of Alzheimer’s disease (AD). Sleep and circadian disruption have been linked to amyloid-β (Aβ) accumulation and neuroinflammation, but whether dim light at night (dLAN) modifies these processes remains unclear. We tested whether chronic dLAN exposure (8 lux during the dark phase, 8 weeks) alters circadian rhythms, amyloid pathology, and neuroinflammation in 12–13 month-old humanized APP knock-in (KI) mice. hAPPSAA KI mice, which develop plaques, were compared with hAPPWT KI controls carrying only a humanized APP sequence. dLAN reduced circadian rhythm amplitude and stability while increasing …
Forecasting Precipitation In Cuba Using Graph Based Deep Learning, Taufiqul Islam
Forecasting Precipitation In Cuba Using Graph Based Deep Learning, Taufiqul Islam
Earth & Environmental Sciences Theses
Daily precipitation forecasting remained a challenging problem in regions characterized by strong spatial heterogeneity, nonlinear atmospheric dynamics, and intermittent rainfall behavior. Cuba represented a particularly complex case due to the combined influence of tropical cyclones, easterly waves, mesoscale convective systems, and orographic effects, which produced highly variable rainfall patterns in both space and time. Conventional statistical and machine-learning models typically treated stations independently and therefore overlooked spatial dependencies that strongly influenced rainfall variability across the island.
This study developed a spatiotemporal deep-learning framework for daily precipitation forecasting across 40 spatial nodes in Cuba using data from 1979 to 2023. The …
Charge‐Governed Mechanistic Evaluation Of Aav2 Clarification Via Functionalized Flat Sheet And Hollow Fiber Deconstructed Depth Filters, Mara Baughman‐Leach, Mattie Brock, Malgorzata Chwatko, Dibakar Bhattacharyya
Charge‐Governed Mechanistic Evaluation Of Aav2 Clarification Via Functionalized Flat Sheet And Hollow Fiber Deconstructed Depth Filters, Mara Baughman‐Leach, Mattie Brock, Malgorzata Chwatko, Dibakar Bhattacharyya
Chemical and Materials Engineering Faculty Publications
The expansion of adeno-associated virus (AAV)-based therapeutics has increased the demand for efficient clarification. In this study, a functionalized deconstructed depth filtration platform was developed to dissect how membrane–virus charge, modulated by pH, influences separation. Three charge regimes, positive (pH 4), neutral (pH 6), and negative (pH 8) between the membranes and AAVs, were examined. The flat-sheet system, composed of sequential 1.2, 0.8, 0.45, and 0.1 µm membranes, enabled the first layer-by-layer analysis of depth filtration behavior. This revealed that Stage 1 and Stage 4 dominate clarification. Remarkably, substantial DNA capture (> 75%) was observed even in the largest-pore stage, …
Creep-Recovery Behavior Of Copper Springs At Low Stresses, Ming-Yen Tsai, Shou-Yi Chang, Yi-Chia Chou, Jyun-Lin Hu, Yulin Zhang, Fuqian Yang, Sanboh Lee
Creep-Recovery Behavior Of Copper Springs At Low Stresses, Ming-Yen Tsai, Shou-Yi Chang, Yi-Chia Chou, Jyun-Lin Hu, Yulin Zhang, Fuqian Yang, Sanboh Lee
Chemical and Materials Engineering Faculty Publications
Copper springs, unlike conventional wires, endure complex stress states such as torsion and bending under sustained thermal and mechanical loads. This study examines the time-dependent creep-recovery behavior of copper springs under low tensile forces at temperatures ranging from 523 K to 623 K, focusing on springs with spring indexes (ratio of mean spring diameter to wire diameter) of 6.4, 8.5, and 9.6. The non-linear Burgers model with a Kelvin solid effectively captures the deformation response and mirrors dislocation nucleation and annihilation kinetics. SEM and TEM imaging reveal that low-angle grain boundaries (LAGBs) act as both dislocation sources and sinks. The …
Candidate Interaction Partners Of Calpain-5 Suggest Clues To Its Involvement In Neovascular Inflammatory Vitreoretinopathy, Jozsef Gal, Vimala Bondada, Rachel Crasta, Dorothy E. Croall, Calvin P. Vary, James W. Geddes
Candidate Interaction Partners Of Calpain-5 Suggest Clues To Its Involvement In Neovascular Inflammatory Vitreoretinopathy, Jozsef Gal, Vimala Bondada, Rachel Crasta, Dorothy E. Croall, Calvin P. Vary, James W. Geddes
Spinal Cord and Brain Injury Research Center Faculty Publications
Although calpain-5/CAPN5 is widely expressed in mammals, little is known regarding its functions. Pathogenic mutations of CAPN5 are causal for a devastating autoimmune eye disease, neovascular inflammatory vitreoretinopathy (NIV). To provide insight into both the physiological and pathological roles of CAPN5, it is essential to identify candidate interaction partners and possible substrates. Human SH-SY5Y neuroblastoma cells, transfected with full-length catalytically dead (Cys81Ala) CAPN5-3×FLAG, were used for anti-FLAG co-immunoprecipitation (co-IP) and quantitative proteomics using Sequential Window Acquisition of all THeoretical mass spectra (SWATH-MS). Fifty-one proteins were enriched at least four-fold, p < 0.01, relative to cells transfected with an empty FLAG vector. A high proportion (24/51) of candidate CAPN5 interaction partners are associated with protein quality control, including components of the chaperonin, chaperone, and ubiquitin–proteasome systems. Additional candidate interactors include tubulins, kinases, phosphatases, G proteins, and mitochondrial proteins. CAPN5 interactions for 14 of the candidate proteins were confirmed by co-IP and immunoblotting. Of these 14 proteins, 11 exhibited in vitro calcium-induced proteolysis following co-IP with WT CAPN5-3×FLAG. Impaired calcium-induced proteolysis of co-IP proteins was observed for the pathogenic CAPN5 variants R243L and R289W. Further studies are needed to validate the association of candidate CAPN5 interactors with proteins and complexes suggested by the SWATH-MS and co-IP results, and the possible role of CAPN5 within such complexes. The possible involvement of CAPN5 in protein quality control is relevant to NIV, as defects in protein quality control have been implicated in inherited retinal disorders. Proteomic data are available via ProteomeXchange with identifier PXD068008.
Developing Curcumin Analogues For Treating Breast Cancer, Tulasi Laxmi Nutalapati
Developing Curcumin Analogues For Treating Breast Cancer, Tulasi Laxmi Nutalapati
Theses, Dissertations and Capstones
Breast cancer is still one of the most common types of cancer and one of the most common causes of cancer-related deaths in women around the world. Despite significant advances in early detection and treatment strategies, drug resistance, systemic toxicity, and poor outcomes in aggressive subtypes continue to limit the overall effectiveness of cancer therapy. Natural compounds have become promising anticancer agents because they can target many different things and are not very toxic. Curcumin has shown promise as an anticancer drug, but it cannot be used in the clinic because it does not absorb well, breaks down quickly, and …
Dino-Lg: Enhancing Vision Transformers With Label Guidance For Coronary Artery Calcium Detection, Mahmut Selman Gokmen, Caner Ozcan, Moneera N. Haque, Steve W. Leung, Seth Parker, Brent Seales, Cody Bumgardner
Dino-Lg: Enhancing Vision Transformers With Label Guidance For Coronary Artery Calcium Detection, Mahmut Selman Gokmen, Caner Ozcan, Moneera N. Haque, Steve W. Leung, Seth Parker, Brent Seales, Cody Bumgardner
Biomedical Engineering Faculty Publications
Coronary artery disease (CAD), one of the leading causes of mortality worldwide, necessitates effective risk assessment strategies, with coronary artery calcium (CAC) scoring via computed tomography (CT) being a key method for prevention. Traditional methods, primarily based on UNET architectures implemented on pre-built models, face challenges like the scarcity of annotated CT scans containing CAC and imbalanced datasets, leading to reduced performance in segmentation and scoring tasks. In this study, we address these limitations by introducing DINO-LG, a novel label-guided extension of DINO (self-distillation with no labels) that incorporates targeted augmentation on annotated calcified regions during self-supervised pre-training. Our three-stage …
Validity And Reliability Of Force Insoles To Measure Center Of Pressure During Return-To-Sport Testing, Delaney Mcneese, Charles Eisner, Rachel Todd, Brian W. Noehren, Meredith K. Owen
Validity And Reliability Of Force Insoles To Measure Center Of Pressure During Return-To-Sport Testing, Delaney Mcneese, Charles Eisner, Rachel Todd, Brian W. Noehren, Meredith K. Owen
Biomedical Engineering Faculty Publications
Center of pressure is a valuable biomechanical variable, predicting joint loading contributions during movement and giving insight into compensatory patterns. The purpose of this study was to assess the validity and reliability of force insoles in calculating vertical ground reaction force and center of pressure during return-to-sport jump testing. Ten healthy individuals performed double- and single-leg vertical and horizontal jumps on an instrumented treadmill while wearing instrumented force insoles. Vertical ground reaction force and anterior–posterior and medial–lateral center of pressure were collected at peak vertical ground reaction force from both devices. Repeat testing occurred 7 ± 5 days following the …
Non-Contact Optical Spectroscopy For Metabolic And Vascular Characterizations Of Orthotopic Tongue Cancer Models In Vivo, Md Zahid Hasan, Jing Yan, Sumit Sarker, Pranto Soumik Saha, Caigang Zhu
Non-Contact Optical Spectroscopy For Metabolic And Vascular Characterizations Of Orthotopic Tongue Cancer Models In Vivo, Md Zahid Hasan, Jing Yan, Sumit Sarker, Pranto Soumik Saha, Caigang Zhu
Biomedical Engineering Faculty Publications
Most tissue optical spectroscopy platforms use a fiber probe for light delivery and collection, while the inconsistent probe-sample contact could induce significant distortions in the measured optical signals, which consequently bring analysis errors. Moreover, it will be practically difficult to use a fiber probe for measurements in some cases such as oral cancer investigations using small animal models. To address the critical challenge, we report a portable, lens-based, optical spectroscopy device capable of quantifying key vascular and metabolic parameters in vivo without probe-sample contact. We combined lenses based diffuse reflectance and fluorescence spectroscopy into one portable platform to enable multi-parametric …
Combined Autofluorescence And Diffuse Reflectance Spectroscopy For Rapid Metabolic And Vascular Characterizations Of Orthotopic Tongue Tumors In Vivo, Pranto Soumik Saha, Jing Yan, Sumit Sarker, Zahid Hasan, Caigang Zhu
Combined Autofluorescence And Diffuse Reflectance Spectroscopy For Rapid Metabolic And Vascular Characterizations Of Orthotopic Tongue Tumors In Vivo, Pranto Soumik Saha, Jing Yan, Sumit Sarker, Zahid Hasan, Caigang Zhu
Biomedical Engineering Faculty Publications
Precise label-free quantification of tissue metabolic and vascular dynamics in vivo represents a critical challenge for cancer therapy prediction and longitudinal treatment assessment. In this study, we demonstrated a portable autofluorescence and diffuse reflectance spectroscopy device along with novel spectroscopic algorithms to quantify tissue vascular and metabolic parameters of orthotopic head and neck cancer models in vivo. Tissue-mimicking phantom studies were used to verify the dual-modal optical spectroscopy and easy-to-use spectroscopic algorithms for rapid and accurate estimation of tissue oxygen saturation, total hemoglobin contents, and intrinsic optical redox ratio. Animal studies were conducted to demonstrate the feasibility of our …
Noninvasive Diffuse Optical Monitoring Of Cerebral Blood Flow And Oxygenation Responses To Intermittent Hypoxia In Neonatal Rats, Pegah Safavi, Mehrana Mohtasebi, Chowdhury Azimul Haque, Faezeh Akbari, Xuhui Liu, Yiqi Yuan, Li Chen, Lei Chen, Guoqiang Yu
Noninvasive Diffuse Optical Monitoring Of Cerebral Blood Flow And Oxygenation Responses To Intermittent Hypoxia In Neonatal Rats, Pegah Safavi, Mehrana Mohtasebi, Chowdhury Azimul Haque, Faezeh Akbari, Xuhui Liu, Yiqi Yuan, Li Chen, Lei Chen, Guoqiang Yu
Biomedical Engineering Faculty Publications
Significance: Intermittent hypoxia (IH) is common in preterm neonates and can cause hypoxic–ischemic brain injury. Simultaneous monitoring of cerebral blood flow (CBF) and oxygenation is essential to detect oxygen delivery-extraction mismatches and guide intervention.
Aim: We aimed to adapt and test an innovative diffuse speckle contrast flow oximetry (DSCFO) system for continuous monitoring of cerebral hemodynamics during IH in neonatal rats, a model approximating human neonates.
Approach: Two compact laser diodes and a miniature CMOS camera were integrated into a fiber-free probe for continuous monitoring of changes in relative CBF (rCBF) and oxy- and deoxy-hemoglobin concentrations (Δ[HbO2] and …
Comparative Evaluation Of R134a And Hfo‐1234ze Cryogen Spray Cooling Using A Mouse Model With Controllable Epidermal Pigmentation, Wangcun Jia, Yurie Jeong, Crystal Huynh, Oswald Lai, Emily Nguyen, Grant Swajian, Jade Niu, Ayana Kashikar, Joshua Khaw, Hong Pu, Bernard Choi, John August D'Orazio, J. Stuart Nelson, Bahman Anvari
Comparative Evaluation Of R134a And Hfo‐1234ze Cryogen Spray Cooling Using A Mouse Model With Controllable Epidermal Pigmentation, Wangcun Jia, Yurie Jeong, Crystal Huynh, Oswald Lai, Emily Nguyen, Grant Swajian, Jade Niu, Ayana Kashikar, Joshua Khaw, Hong Pu, Bernard Choi, John August D'Orazio, J. Stuart Nelson, Bahman Anvari
Pediatrics Faculty Publications
Objectives: Cryogen spray cooling (CSC) is critical for protecting the epidermis during laser dermatologic procedures. The widely used cryogen, R134a, has a high global warming potential (GWP), motivating interest in environmentally favorable alternatives such as HFO-1234ze. This study evaluated whether HFO-1234ze provides epidermal protection comparable to R134a during laser exposure and investigated the mechanistic basis underlying any differences in cooling performance.
Methods: Laser-induced epidermal injury in conjunction with two cryogens was assessed in K14-SCF Mc1re/e mice with pharmacologically controllable interfollicular epidermal pigmentation. Laser treatment sites were assigned fluences relative to baseline skin lightness (L*) to span subthreshold …
Buzzes Over Burrows: Bats And Black-Tailed Prairie Dogs In Western Kansas, Patrick L. Geyer
Buzzes Over Burrows: Bats And Black-Tailed Prairie Dogs In Western Kansas, Patrick L. Geyer
Master's Theses or Doctor of Nursing Practice
The native grasslands of the Great Plains and the organisms that inhabit them are threatened by the anthropogenic disturbance of land-use change; prairie dogs (Genus Cynomys) are one such example. These mammals are considered ecosystem engineers due to their behaviors that physically modify the areas they inhabit, directly affecting the resources available to surrounding organisms. Much research exists on established or potential relationships between black-tailed prairie dogs (Cynomys ludovicianus) and other taxa; until recently, one taxon group absent from mentions of an association with black-tailed prairie dogs was bats (Order Chiroptera). Results of acoustic studies in eastern …
Simulation And Characterization Of Fuel Cell System Incorporated Internet Of Things, Ahmad N. Alhjouj
Simulation And Characterization Of Fuel Cell System Incorporated Internet Of Things, Ahmad N. Alhjouj
Mechanical Engineering Theses
Small air-cooled proton exchange membrane fuel cell (PEMFC) systems are increasingly relevant for portable and distributed applications, yet practical modeling and monitoring methods remain limited: high-fidelity physics-based models are too costly for real-time use, while purely data-driven models discard physical interpretability. This thesis develops an experimentally grounded gray-box framework for the characterization, reduced-order modeling, and IoT-enabled monitoring of a small hydrogen PEMFC system. A low-order nonlinear state-space model couples an electrochemical voltage layer to a lumped thermal layer, with parameters identified in stages using self-adaptive differential evolution. Identifiability analysis shows that static loss parameters are well constrained, while dynamic parameters …
Barriers To Creativity: Addressing Anxiety And Self-Doubt In Secondary Visual Arts Students, Wenlai Fang
Barriers To Creativity: Addressing Anxiety And Self-Doubt In Secondary Visual Arts Students, Wenlai Fang
All Electronic Theses and Dissertations
Adolescence is a crucial stage for self-development and creativity development. During this period, middle school students will experience creative anxiety and self-doubt about creative expression in multiple dimensions. To help students manage the uncertainties inherent in the creative process and build confidence and resilience, this study, based on Rhodes' (1961) 4P creativity framework (Person, Process, Press, and Product), systematically investigated the obstacles to the development of adolescent creativity and identified teaching intervention measures for fostering a supportive creativity ecosystem.
This study demonstrated that the development of adolescent creativity is a result of multi-faceted and multi-dimensional interactions from the 4P creativity …