Digital Commons Network^™

An Optimization-Driven Approach For Accurate Prediction Of Diabetes Mellitus, H El Bouhissi, Sb Xu, John H Wang

Department of Information Management and Business Analytics Faculty Scholarship and Creative Works

Diabetes mellitus is a progressive metabolic disorder requiring timely identification to prevent severe complications and reduce healthcare burdens. This paper proposes an optimization-driven deep learning framework for accurate diabetes prediction, integrating Long Short-Term Memory selection and hyperparameter tuning. The framework is conceptualized as a decision-support system embedded within electronic health records and clinical workflows, supporting physicians, nurses, case workflow integration, governance, and privacy-are addressed to ensure alignment with real-world organizational contexts. The results demonstrate both technical feasibility and practical relevance, linking predictive analytics capability with human-AI collaboration, adoption factors, and operational decision-making in healthcare organizations.

Investigation Of Genx Exposure To Pathways Associated With Colorectal Cancer Risk, Emily J. Ferguson

Theses and Dissertations--Toxicology and Cancer Biology

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants widely detected in drinking water and food sources, resulting in chronic human exposure. Among these compounds, hexafluoropropylene oxide dimer acid (HFPO-DA), commonly known as GenX, has been introduced as a short-chain replacement for legacy PFAS such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Although GenX is believed to be a safer alternative, emerging research suggests it can still affect human health.

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related death in the United States, highlighting the need to better understand environmental …

Uncovering The Mechanism Of Reep2-Mediated Emt-Driven Membrane Trafficking In Lung Adenocarcinoma, Kevin Fulp

Theses and Dissertations--Toxicology and Cancer Biology

Membrane trafficking is frequently disrupted during cancer progression, and the underlying mechanisms remain largely unknown. Currently, no effective drugs target dysregulated membrane trafficking for cancer treatment. Recent evidence has demonstrated that epithelial-to-mesenchymal transition (EMT) in lung adenocarcinoma (LUAD) employs a membrane trafficking program to coordinate cancer cell invasion and immunosuppression. To further dissect the pro-tumorigenic membrane trafficking program, we initiated an in vivo CRISPRi screen to assess more than 2,000 membrane trafficking-related genes in a syngeneic mouse LUAD model. We identified REEP2, an endoplasmic reticulum (ER) shaping protein, as a novel regulator of EMT-driven membrane trafficking. High REEP2 expression is …

Reep2-Driven Pro-Metastatic Secretion Promotes Lung Cancer Progression, Oluwafunminiyi E. Obaleye

Theses and Dissertations--Toxicology and Cancer Biology

Membrane trafficking plays a critical role in cellular function and is frequently dysregulated in cancer to promote metastasis. In lung adenocarcinoma (LUAD), the epithelial-to-mesenchymal transition (EMT) activating transcription factor, ZEB1, drives a pro-metastatic membrane trafficking program; however, the underlying molecular mechanisms remain poorly understood. Using a CRISPR interference (CRISPRi) in vivo screen of 2,099 membrane trafficking regulators in a syngeneic mouse model of EMT-driven LUAD, we identified REEP2 — an endoplasmic reticulum (ER) shaping protein — as a critical regulator of tumor progression. REEP2 mRNA expression correlates with poor prognosis, EMT signatures, and an immunosuppressive tumor microenvironment in LUAD patients. …

Public Schools: The Battleground Between Church And State, Brian Boggs

Western New England Law Review

Over the course of the last 50 years, specific jurisprudence has been developed relating to First Amendment rights in schools. Specifically, there have been several cases that set rules for religious freedoms and practices in schools—a  trinity of rights made up of the Establishment Clause, Free Exercise Clause, and Free Speech Clause—that form a framework to guide jurists and educational practitioners. However, the U.S. Supreme Court has drastically changed their course over the last several years, and the standards of review related to these cases. This trend is likely to continue. This paper provides a historical overview of the development …

The Ones Who Watched: Technology, Proxy Warfare, And The Testing Ground Hypothesis, Sean J. Oliver

Graduate Theses/Dissertations

Great powers need laboratories for war. This thesis argues that great powers find these laboratories in proxy forces. Proxy warfare is not just a tool for strategic influence. It is a machine for experimentation. This study posits a central testing-ground hypothesis. It contends that great powers deliberately use surrogates to vet emerging technologies, doctrines, and mobilization schemes under the pressure of real combat. The analytical methodology is historical. It traces patterns from the ancient world's proxy forces and the innovations of the Crusades to the Cold War and the digital age. The thesis examines enduring patterns, including the tension between …

Stopping The Buck: What Made The Truman Committee Uniquely Successful In Its Oversight Of World War Two Military Contracts, Victoria Kelley-Chiarelli

Graduate Theses/Dissertations

During World War Two, Harry S. Truman led the Senate Select Committee to Investigate the National Defense Program, also known as the Truman Committee, in its oversight of military contracts and the war effort. The Truman Committee saved the U.S. government billions by identifying and discouraging waste, fraud, and abuse, and saved many armed forces personnel’s lives through identifying defective products. Truman’s background in World War One service and his time as a local official in Missouri show signs of the integrity and commitment to good governance that made the Truman Committee so successful. The Truman Committee’s membership, staff, principles, …

Heterogeneous Robots Cooperation Via Multi-Agent Reinforcement Learning, Rehab Uddin Shawon

Graduate Theses/Dissertations

Enabling heterogeneous robots with diverse capabilities, roles, and task responsibilities to coordinate effectively in complex, dynamic environments remains a fundamental challenge in autonomous multi-robot systems. Multi-Agent Reinforcement Learning (MARL) provides a promising framework for decentralized cooperation. However, most existing MARL approaches assume homogeneous agents or fixed single-task settings and suffer significant performance degradation as the number of robot and task types increases. This thesis presents a scalable shared-policy MARL framework that allows heterogeneous robots to learn specialized behaviors for individual, sequential, and collaborative tasks involving temporal and spatial dependencies through a single neural policy. I first embed robot identity directly …

Europe In The Indo-Pacific - Implications For The United States, Joshua G. Zinicola

Graduate Theses/Dissertations

Within the last five years the Indo-Pacific has become a region of increasing interest to European NATO members. In particular, the United Kingdom, France, and Italy have assigned strategic importance for their national security to the region, signing cooperative agreements with regional allies of the United States and deploying significant forces to the region. These agreements include commitments to jointly develop new technologies and combat systems for employment in both Europe and the Indo-Pacific, such as the Global Combat Air Programme (GCAP), and the Trilateral security partnership between Australia, the United Kingdom, and the United States (AUKUS). They also include …

Lsu General Catalog 2026-2027, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students

From Sediment To Mangrove: Tissue-Specific Metal Accumulation In Red Mangroves Of Southeastern Florida, Sophie Welch

Honors Theses

Coastal wetlands near industrialized waterways face increasingly heavy‐metal contamination, posing risks to benthic communities and food webs. Mangroves can influence metal cycling through sediment trapping, root‐zone sequestration, and internal physiological regulation, yet their effectiveness in urbanized systems remains debated. This study quantified concentrations of 17 heavy metals in sediments and mangrove tissues from four sites near Port Everglades, Florida, examined tissue‐specific partitioning, spatial and temporal contamination patterns, and examined the mangroves’ role in mediating metal loads. Ecological risk metrics identified STB as a contaminant hotspot with exceedances of TEL values across multiple elements (Ni, Pb, and Zn) as well as …

A Taxonomy-Driven Modular Defense Against Non-Canonical Language In Vision-Language-Action Models, Viraj Samson

Electronic Theses and Dissertations

Vision-Language-Action (VLA) models have recently achieved strong performance across manipulation benchmarks, but these benchmarks rely on highly templated instructions on which the models are typically fine-tuned, leaving their behavior under realistic language-side perturbation unclear. It remains an open question whether the linguistic flexibility inherited from vision-language pretraining survives this fine-tuning, or whether the resulting policies become narrowly tuned to benchmark phrasing and brittle to the intent-preserving language variation that real users naturally produce. We address this gap with a systematic study of VLA robustness under non-canonical instructions, comprising three components: a structured taxonomy of intent-preserving variations spanning linguistic, orthographic, and …

Data-Driven Optimization Of Memory Effects And Critical Components In Cascading Failure Interaction Networks, Md Farhan Tanvir

Electronic Theses and Dissertations

Cascading failures are a major concern for modern power systems‚ where a small failure can cascade through the network to create a large blackout. Because such an event could have catastrophic economic and social costs it is important to understand cascading failures‚ how to model them‚ and the possibility of reducing them. In this thesis‚ we develop a data-driven framework based on actual utility outage data to model and reduce cascading failures. The proposed methodology is based on generation-dependent interaction models and in this study interaction matrices obtained from historical outage events are used to describe the interaction between generations. …

Computational Modeling Of Biophysical Transport: Respiratory Drug Delivery And Tissue-Level Physics, Md Tariqul Hossain

Electronic Theses and Dissertations

The nasopharynx, the upper part of the pharynx located at the back of the nose serves as a critical hotspot for initial respiratory infections via inhaled transmission, largely due to the presence of specific surface receptors that pathogens can exploit for cell invasion, combined with a relatively sparse local mucociliary substrate. To enhance the therapeutic efficacy against certain pathogens, such as the SARS and Influenza viruses, it is therefore essential to improve the targeted delivery of drugs to the nasopharynx. This study explores the use of intranasal sprays as a method for drug administration and models the transport of sprayed …

Numerical Investigation Of Injector Location And Equivalence Ratio In A Flame‐Holder Cavity Scramjet, Matthew Sorenson

Electronic Theses and Dissertations

This thesis presents a CFD-based parametric study of injector location and fuel rate in an ethylene-fueled flame-holder cavity scramjet using STAR-CCM+. Simulations are performed for three injector locations (x/D = 18, 36, and 54) and nine equivalence ratios spanning from ϕ = 0.2 to 1.0 in 0.1 increments. The study aims to determine how injector placement and fueling level alter scramjet performance across a broad operating sweep. The results show a clear regime change between ϕ = 0.2 and ϕ ≥ 0.3. At ϕ = 0.2, combustor behavior is weakly sensitive to injector location compared to the higher-fueling cases. For …

Cyber Security Related To Agricultural Data Encryption Using Edge Computing Devices, Mohammad Ashik Alahe

Electronic Theses and Dissertations

Smart Agriculture increasingly relies on image-based sensing, edge computing, and artificial intelligence to support data-driven decision-making in modern farming systems. While these technologies improve productivity and resource efficiency, they also introduce significant cybersecurity risks, particularly agricultural images transmitted and processed in real-time on resource-constrained edge devices. Unauthorized access, data manipulation, and interception of image data can lead to incorrect agronomic decisions and severe economic consequences. Despite this risk, efficient and practical cybersecurity solutions for real-time agricultural imaging remain limited. This study addresses these challenges by developing and evaluating encryption-based cybersecurity frameworks tailored for real-time agricultural image protection on edge computing …

Access Resource Guide For Bay Area Cultural Arts Organizations Developed In Collaboration With People With Intellectual And Developmental Disabilities, Clarissa Junio

Occupational Therapy | OTD Capstone Projects

Background: Hidden access barriers persist within cultural arts organizations. As a result, people with IDD continue to experience reduced levels of community participation, limiting the associated benefits to health, well-being, and quality of life. Organizational-level occupational therapy (OT) consultation can address barriers and expand organizational capacity to meet the needs of people with IDD.

Purpose: The project aimed to strengthen organizational capacity of Bay Area cultural arts organizations and expand existing accessibility resources by co-developing a resource guide centered on lived experience to maximize community social participation for people with IDD. The guide was disseminated to cultural arts …

Challenging Stem Learning Spaces: The Paradigm Of Contemplative Traditions As The Bedrock Of Creativity And Healing, Raaghav Pandya, Christopher Emdin

Publications and Research

As the post-pandemic classroom and pedagogy evolve to remedy oppressive norms, young people’s mental health and alienation has taken front stage (Rahmani & Zitouni, 2022). Traditional STEM learning spaces often teach inquiry as a linear, non-deviated approach to problems about self and nature (Hrisa & Psillos, 2022). Furthermore, because our classrooms often strip students and educators of their inherent creative abilities through constant assessments, improvement scales, and market-driven expectations, classrooms cease to become places of healing (Pandya, 2021). Eastern wisdom traditions and their associated philosophies provide a unique pedagogical lens that emphasizes a deep inquiry into self, empathy, and creativity …

Ancient Wisdom & Its Cultural Relevance: Reimagining Deeper Learning In Science Classrooms Through The Lens Of Yoga And Vedānta, Raaghav Pandya

Publications and Research

Contemporary calls to reconceptualize how science is taught and understood have brought deeper learning to the forefront of education at-large for its emphasis on critical perspectives, creativity, and student-centered inquiry. Yet this paper argues that its prevailing framework remains constrained by Cartesian dualism, a materialist foundation that disassociates the individual from self, other, and nature, and falls short of addressing the mental health, environmental, and cultural challenges facing youth today. To address this limitation, this paper proposes a complementary convergence between deeper learning and the contemplative traditions of Yoga and Vedānta, whose ancient paradigms of self-inquiry, interconnectedness, and well-being offer …

Impact Of Foreign Direct Investment On Employment In The Metropolitan Statistical Areas Of North Carolina, Matthew Y. Xiong

Doctor of Business Administration Dissertations

Foreign direct investment (FDI) is widely recognized as a catalyst for regional economic development; however, limited research has examined its relationship with employment growth at the metropolitan level within individual U.S. states. This study examined the relationship between FDI and employment growth across fifteen North Carolina Metropolitan Statistical Areas (MSAs) from 2010 to 2019. Guided by Dunning's Eclectic (OLI) Paradigm (1988), Endogenous Growth Theory, the Human Capital/Absorptive Capacity Framework, and Institutional Capacity Theory, this quantitative study employed a balanced panel dataset of 150 MSA-year observations. Fixed-effects panel regression models with cluster-robust standard errors were used to examine the effects of …

Examining The Causes And Consequences Of Diverse Agricultural Management Practices On Land Carbon Dynamics In Eastern South Dakota, Khushboo Jain

Dissertations and Theses

Climate-smart agricultural practices such as conservation tillage, increased crop residue cover, and cover cropping play a critical role in improving soil health, enhancing climate resilience, and reducing carbon losses from croplands. However, their spatial distribution, long-term impacts on land–atmosphere carbon fluxes, and the ability to monitor them efficiently at regional scales remain insufficiently understood. This dissertation addresses these gaps through an integrated remote sensing, machine learning, and modeling framework applied across eastern South Dakota. Firstly, I developed a satellite-based approach to map tillage practices and detect cover crop presence using multisource spectral indices and environmental drivers. A machine learning classifier …

Virginia Commonwealth University Professional Bulletin (2026), Virginia Commonwealth University

VCU Bulletins

Professional programs bulletin for Virginia Commonwealth University for the academic year 2026-2027. It includes information on academic regulations, degree requirements, course offerings, faculty, academic calendar, and tuition and expenses.

Virginia Commonwealth University Courses (2026), Virginia Commonwealth University

VCU Bulletins

Listing of courses for the 2026-2027 year.

Virginia Commonwealth University Undergraduate Bulletin (2026), Virginia Commonwealth University

VCU Bulletins

Undergraduate bulletin for Virginia Commonwealth University for the academic year 2026-2027. It includes information on academic regulations, degree requirements, course offerings, faculty, academic calendar, and tuition and expenses for undergraduate programs

Virginia Commonwealth University Graduate Bulletin (2026), Virginia Commonwealth University

VCU Bulletins

Listing of courses for the 2026-2027 year.

Preceptor Preparedness And Its Effect On Newly Hired Nurse Retention, Nena Theresa Hatchett

West Chester University Graduate Theses, Dissertations, and Final Projects

Abstract

The transition from nursing student to professional practice is a high-risk period for newly graduated registered nurses (NGRNs), often associated with role strain, limited clinical confidence, and high turnover. Structured preceptor mentorship programs have been identified as critical interventions to support both preceptors and NGRNs, enhancing job satisfaction, instruction competence, and workforce retention. This Doctor of Nursing Practice (DNP) project employed a quality improvement design guided by Lewin’s Change Theory to evaluate the impact of a structured preceptor mentorship program in a mid-sized acute care hospital. Five preceptors and twelve NGRNs participated in an eight-week intervention that included mentor …

Wearable Biosensors For Continuous Monitoring Of Chronic Kidney Disease: Materials, Biofluids, And Digital Health Integration, Anupamaa Sivasubramanian, Shankara Narayanan, Gymama Slaughter

Center for Bioelectronics Publications

Chronic kidney disease (CKD) is a progressive and irreversible disorder affecting over 850 million individuals globally and is associated with significant morbidity, mortality, and healthcare burden. Conventional diagnostic approaches rely on intermittent laboratory measurements, including serum creatinine, estimated glomerular filtration rate (eGFR), and urinary albumin, which provide limited temporal resolution and fail to capture dynamic physiological changes. Recent advances in wearable biosensing technologies offer new opportunities for continuous, non-invasive monitoring of biochemical and physiological markers relevant to renal function. This review provides a comprehensive analysis of wearable biosensors for CKD monitoring, focusing on sensing mechanisms (electrochemical, optical, and field-effect transistor), …

Ai-Assisted Surface-Enhanced Raman Spectroscopy For Cardiovascular Diagnostics: From Plasmonic Materials To Clinical Translation, Anju Joshi, Gymama Slaughter

Center for Bioelectronics Publications

Raman spectroscopy (SERS) has emerged as a powerful analytical technique, offering molecular fingerprint specificity and ultrasensitive detection of cardiac biomarkers. Recent advances in plasmonic nanostructures, surface functionalization strategies, and flexible sensing platforms have significantly improved the analytical performance of SERS-based biosensors. In parallel, the integration of artificial intelligence (AI) and machine learning has enabled robust interpretation of complex spectral datasets, facilitating automated biomarker classification and improved diagnostic accuracy in heterogeneous biological environments. Despite these advances, the field remains fragmented, with limited integration between nanomaterial design, biomarker selection, and data-driven analysis, and persistent challenges related to reproducibility, standardization, and clinical validation. …

Modulation Of Prussian Blue Redox Signaling By Molecular Imprinting For Reagent-Free Electrochemical Detection Of Emtricitabine, Abdellatif Ait Lahcen, Gymama Slaughter

Center for Bioelectronics Publications

Reagent-free electrochemical sensors offer significant benefits for rapid, affordable point-of-care drug testing. In this study, we introduce a novel, reagent-free electrochemical sensor based on a molecularly imprinted polymer (MIP) specifically designed for the selective detection of Emtricitabine (FTC), a common antiretroviral used in HIV therapy. The sensor uses laser-induced graphene (LIG) electrodes, renowned for their high conductivity and porosity, ideal for electrochemical sensing. To enable reagent-free operation, the LIG surface was electrochemically coated with Prussian Blue, serving as a redox-active layer. Next, an MIP-PPy film was electropolymerized onto the Prussian Blue surface in the presence of FTC as a template, …

Ion-Imprinted Polymer-Based Sensors For Toxic Metal-Ion Detection In Water: Coordination Chemistry, Transduction Strategies, And Environmental Applications, Ghita Yammouri, Gymama Slaughter

Center for Bioelectronics Publications

Toxic metal contamination in aquatic environments remains a persistent threat to human health and ecosystems. Yet, the high cost, infrastructure demands, and centralized nature of conventional analytical methods constrain routine monitoring. Ion-imprinted polymers (IIPs), a subclass of molecularly imprinted polymers, have emerged as promising synthetic recognition materials for metal-ion sensing because they generate coordination-defined binding sites with high selectivity, chemical stability, low cost, and reusability. This review summarizes recent advances in Ion-imprinted polymer (IIP)-based sensing technologies for toxic metal-ion detection in water from 2016 to 2026. It examines the fundamental recognition chemistry of IIPs, major synthesis strategies used to generate …