Digital Commons Network^™

Taming Psoriatic Inflammation: Targeting The Inos–Oxidative Stress–Necroptosis Axis For Precision Therapy, Tolulope Omotope Omolekan, Tithi Roy, Jean Christopher Chamcheu

Faculty Publications

Necroptosis is increasingly recognized as a central driver of psoriatic inflammation, promoting keratinocyte death and sustaining immune activation. Recent evidence shows that inducible nitric oxide synthase (iNOS) deficiency and exogenous nitric oxide (NO) supplementation ameliorate psoriasis-like dermatitis in mice by reducing oxidative stress and constraining necroptotic signaling. These findings identify iNOS-derived NO as both a mediator of reduction–oxidation (redox) imbalance and a key regulator of necroptosis, thereby advancing mechanistic insight into psoriatic pathogenesis. Importantly, they highlight the iNOS–oxidative stress–necroptosis axis as a translationally actionable therapeutic target. Modulating necroptotic cell death through NO-based interventions may restore epidermal homeostasis and improve clinical …

Conserved Chromatin Programs Orchestrate Cardiac Cell States In Health And Disease And Drive Cardiomyocyte Proliferation After Injury, Xiaoxiao Geng

ETDs from 2020-2029

Chromatin structure is a central regulator of gene expression and cellular identity, yet the chromatin structural factors driving cardiac disease and regeneration remain incompletely defined. This dissertation investigates how modulation of chromatin architecture shapes pathological and regenerative cardiac phenotypes through integrated single-cell transcriptomic, epigenomic, and functional analyses. To determine whether chromatin structural regulators distinguish healthy from diseased cardiac states, we curated a comprehensive list of chromatin structural genes and applied it to single-nuclei RNA sequencing datasets from human hearts with and without dilated cardiomyopathy (DCM). Chromatin structural gene expression effectively stratified cardiomyocyte and fibroblast populations by disease status. Diseased cardiomyocytes …

Effects Of Hydro- And Nano-Priming Treatments On Seed Germination And Metabolism In Sugar Beet (Beta Vulgaris L.), Sarah Jorjani, Ömer Can Ünüvar, Songül Gürel, Ekrem Gürel

Turkish Journal of Botany

This study examined the effects of hydropriming and nanopriming on the germination and physiological parameters of sugar beet seeds. Seeds were treated with distilled water as a traditional method and with TiO2 nanoparticle solutions at concentrations of 5, 10, and 15 ppm as an advanced method. Seeds were soaked for 3, 6, and 9 h, followed by postpriming maintenance for 10 and 45 days. T he results indicated no statistically significant differences in germination rates between the control and primed groups. Both priming methods markedly increased alpha-amylase activity and chlorophyll content, indicating improved metabolic and photosynthetic potential. Notably, nanopriming for …

Modeling Global Ecological Niche Shifts Of Osyris Spp. Under Climate Change Scenarios: Conservation Priorities For A Threatened Genus, Meng Ting-Yao, Han Shun-Long, He Xiang-Tian, Wu Ya-Ni, Fengjuan Mou

Turkish Journal of Botany

The genus Osyris L. comprises ecologically and economically important evergreen shrubs or small trees, with particular African species currently threatened by unsustainable exploitation. This study projected potential ecological niche shifts for Osyris under four Shared Socioeconomic Pathways (SSPs) using digitized herbarium specimen localities and 20 environmental variables. The genus currently occupies a broad range between 41.32°N–34.85°S latitude and 9.27°W–109.03°E longitude, at elevations from 0 to 3900 m. High-suitability areas cluster primarily in the European-Mediterranean region, eastern/southern Africa, western South America, and Southeast Asia. Projections indicate a significant decline in high-suitability area under all SSP scenarios (SSP126, SSP245, SSP370, SSP585) compared …

Taxonomic Significance Of Stem And Leaf Anatomy And Pollen And Seed Micromorphological Characters In The Papaver (Poppy) Sect. Rhoeadium From Türkiye, Esengül Özkaymakoğlu, Osman Tugay, Yavuz Bülent Köse, Deni̇z Ulukuş, Bayram Atasagun, Meti̇n Armağan, Ferhat Celep

Turkish Journal of Botany

The poppy (Papaver) has beautiful flowers that attract the attention of not only taxonomists but also the public. However, it also presents several taxonomic problems. This study examines 13 taxa of Papaver sect. Rhoeadium, including the following species native to Türkiye: P. purpureomarginatum, P. dubium subsp. dubium, P. dubium subsp. laevigatum, P. arachnoideum, P. arenarium, P. commutatum subsp. euxinum, P. guerlekense, P. rhopalothece, P. stylatum, P. clavatum, P. syriacum, P. rhoeas, and P. postii. Plant specimens were collected from natural populations, and anatomical investigations were carried out on stem and leaf cross-sections. Pollen and seed features were examined using both …

Psychologists’ Attitudes On Capital Punishment And Interpretation Of The American Psychological Association’S Ethics Code, Darya Baugh-Ruschman

Walden Dissertations and Doctoral Studies

When defendants are sentenced to death due to the nature of the crime, psychologists may be asked to participate in these cases, performing tasks such as conducting competency evaluations. Because the American Psychological Association (APA) Ethics Code states that psychologists cannot participate in activities that violate human rights, an ethical debate has emerged regarding whether they should participate in capital cases. The present study examined psychologists’ opinions on capital punishment and their interpretation of the APA Ethics Code, which does not specifically define what constitutes a violation of human rights. The theoretical framework for the study is the ethical decision-making …

The Risc-V Fpga (Rvfpga) Teaching Package, Daniel Chaver, Sarah Harris, Luis Pinuel, Olof Kindgren, Zubair Kakakhel, Chris Owen, Roy Kravitz, Jose I. Gomez-Perez, Fernando Castro, Katzalin Olcoz, Multiple Additional Authors

Electrical and Computer Engineering Faculty Publications and Presentations

RISC-V is a free and open-standard ISA based on RISC principles, allowing anyone to design, manufacture, and sell RISC-V chips and software. Its flexibility and growing ecosystem have made it popular in research, education, and industry, increasing the need for educational materials. This paper provides an in-depth description of the RVfpga course, which offers a solid introduction to computer architecture using the RISC-V instruction set and FPGA technology. It focuses on providing hands-on experience with real-world RISC-V cores, the VeeR EH1 and EL2 cores, developed by Western Digital and hosted by ChipsAlliance. The course targets students and educators in computing-related …

Black Hole Spectroscopy And Tests Of General Relativity With Gw250114, The Ligo Scientific Collaboration, The Virgo Collaboration, The Kagra Collaboration

Department of Physics and Astronomy Faculty Scholarship and Creative Works

The binary black hole signal GW250114, the loudest gravitational wave detected to date, offers a unique opportunity to test Einstein’s general relativity (GR) in the high-velocity, strong-gravity regime and probe whether the remnant conforms to the Kerr metric. Upon perturbation, black holes emit a spectrum of damped sinusoids with specific, complex frequencies. Our analysis of the postmerger signal shows that at least two quasinormal modes are required to explain the data, with the most damped remaining statistically significant for about one cycle. We probe the remnant’s Kerr nature by constraining the spectroscopic pattern of the dominant quadrupolar (ℓ =𝑚 =2) …

The Joy Above All Joys: Roland D. Sawyer’S Socialism For The Working Class, Maggie R. Buglino

Roland D. Sawyer Scholarship Papers

Following the Industrial Revolution, Americans were required to adapt to the nation's new capitalistic society. Witnessing the subsequent struggle of working-class families, 20th century Christian socialist Roland D. Sawyer was resolved to advocate for a reformed economic structure. This paper is dependent entirely on primary sources in the Roland D. Sawyer Collection, available in the University of New Hampshire's Milne Special Collections. Studying Sawyer's autobiography and various socialist writings illustrates his idea of a good life for the American working-class and how they were to achieve it through the adoption of a socialist doctrine. Throughout his activism, he encouraged Americans …

Updating Misev: When, What, How, And Why?, Naveed Akbar, Dylan Burger, Benedetta Bussolati, Edit Buzás, Randy Carney, Young-Eun Cho, Tom Driedonks, Juan Manuel Falcon-Perez, Yu Fujita, Deborah Goberdhan, An Hendrix, Yiyao Huang, Suresh Mathivanan, Mỹ Mahoney, Sujata Mohanty, Andreas Möller, Nicole Noren Hooten, Stefano Pluchino, Carlos Salomon, Ana Claudia Torrecilhas, Sara Veiga, Kenneth Witwer

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

No abstract provided.

Combined Glycoprotein Mutations In Rabies Virus Promote Astrocyte Tropism And Protective Cns Immunity In Mice, Mirjam Anna Rita Bertoune, Corinna Kolbe, Ann-Cathrin Werner, Maren Steinmetz, Bernhard Dietzschold, Eberhard Weihe

Department of Microbiology and Immunology Faculty Papers

Rabies virus (RABV) causes fatal encephalitis once it invades the central nervous system (CNS), and treatment options are extremely limited at this stage. We investigated the recombinant RABV variants SPBN, SPBNGA (glycoprotein substitution R333E), SPBNGAK (R333E plus N194K), SPBNGAS (R333E plus N194S), and TriGAS (three copies of the R333E/N194S glycoprotein). We evaluated their cellular tropism and immune activation in an intracerebral mouse infection model using immunohistochemistry and confocal immunofluorescence. SPBNGAK (R333E/N194K) resulted in mixed neuronal and astrocytic infection and lethal disease. In contrast, the R333E/N194S mutations in the GAS variants were associated with reduced neuronal infection and apparent astrocyte-restricted infection …

Structural Empowerment And The Work Environment Of Nursing Home Care Workers In China, Yawen Ou

Lingnan Theses (MPhil & PhD)

China is experiencing a profound demographic transformation as its population ages rapidly, driven by declining fertility, increased longevity, and long-term effects of the One- Child policy. Traditional family-based elderly care has become increasingly unsustainable due to the pressures of the “4-2-1” family structure and the rising prevalence of empty-nest households. In this context, there is an increasing trend in institutionalized elderly care, accompanied by a growing demand for Nursing Home Care Workers (NHCWs). In spite of their vital importance, NHCWs often face heavy workloads, poor compensation, low recognition, and limited professional autonomy. This study explores the work environment and structural …

Oncofetal Reprogramming: A New Frontier In Cancer Therapy Resistance, Anh Nguyen, Molly Lausten, Bruce M. Boman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Oncofetal reprogramming has recently emerged as a critical concept in translational cancer research, particularly for its role in driving therapeutic resistance across a variety of malignancies. This biological process refers to a pattern of gene expression that is restricted to embryogenesis, but becomes expressed again in a subpopulation of cancer cells. These genes are typically suppressed after embryogenesis, and their aberrant re-expression in tumors endows cancer cells with stem-like properties and enhanced adaptability. The goal of this review is the following: (i) comprehensively examine the multifaceted nature of oncofetal reprogramming; (ii) elucidate its underlying molecular mechanisms, including its regulators and …

Black Hole Spectroscopy And Tests Of General Relativity With Gw250114, A. G. Abac, I. Abouelfettouh, Teviet Creighton, Mario C. Diaz, Raul Alberto Espinosa Perez, J. Lawrence, Francisco Llamas Villarreal, Soma Mukherjee, Volker Quetschke, Miriam Ramos Arevalo, Wenhui Wang

Physics & Astronomy Faculty Publications

The binary black hole signal GW250114, the loudest gravitational wave detected to date, offers a unique opportunity to test Einstein’s general relativity (GR) in the high-velocity, strong-gravity regime and probe whether the remnant conforms to the Kerr metric. Upon perturbation, black holes emit a spectrum of damped sinusoids with specific, complex frequencies. Our analysis of the postmerger signal shows that at least two quasinormal modes are required to explain the data, with the most damped remaining statistically significant for about one cycle. We probe the remnant’s Kerr nature by constraining the spectroscopic pattern of the dominant quadrupolar (ℓ =𝑚 =2) …

Risk Awareness Of Alcohol Related Car Fatalities In Whatcom County, Tayler Wilson

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement

My goal to address alcohol-related traffic fatalities in Whatcom County is to reduce the prevalence of these fatalities by 20% over two years through preventative community education and targeted enforcement programs to decrease high-risk drinking behaviors in college-age youth.

Significant Findings

There has been a significant rise in alcohol-related traffic fatalities within Whatcom County, upwards of 50% of fatal car accidents in 2024 involving alcohol; 67.8% higher than the national average (CDC, 2024; Starks et al.,2025). The population most impacted by this public health risk is 21-24 year-olds, especially young men, who are four times more likely to …

The Origin Of Hepatocellular Carcinoma Depends On Metabolic Zonation, Jason Guo, Roger Liang, Andrew Chung, Zhijie Li, Boyuan Li, Eric Chen, Lin Li, Jingjing Wang, Meng-Hsiung Hsieh, Ivy Xiangyi Fang, Benjamin Kroger, Yunguan Wang, Min Zhu, Xiongzhao Ren, Greg Mannino, Yuemeng Jia, Yonglong Wei, Stephen Moore, Daniel J Siegwart, Stephen S Chung, Zixi Wang, Tripti Sharma, Suman Komjeti, Yi Han, Purva Gopal, Guanghua Xiao, Tao Wang, Hao Zhu

Faculty, Staff and Student Publications

The origin of cancer is poorly understood because premalignant cells are rarely followed in their native environments. Although the spatial compartmentalization of metabolic functions is critical for proper liver function, it is unknown whether cancers arise from some zones but not others and whether there are metabolic determinants of cancer risk. Zone-specific, mosaic introduction of Ctnnb1 (catenin beta 1) and Arid2 (AT-rich interaction domain 2) mutations, commonly co-mutated genes in hepatocellular carcinoma (HCC), in mouse models showed that position and metabolic context determine clone fates. Ctnnb1/Arid2-driven cancers were much more likely to arise in zone 3. The …

Modes Of Liability For Ai-Enabled Crimes In International Criminal Law, Antonio Coco

International Law Studies

As artificial intelligence (AI) technologies become increasingly embedded in human activity, the question of individual accountability for AI-enabled international crimes grows more pressing. This article examines how established doctrines of individual criminal responsibility under international criminal law—particularly the modes of liability recognized in the Statute of the International Criminal Court and in the jurisprudence of international criminal tribunals—may be applied to human actors who interact with AI systems in the commission of core international crimes. Through four hypothetical scenarios, the article explores varying forms of human involvement—from programming to deployment—and assesses whether existing modes of liability, such as perpetration, instigation, …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Faculty Senate Minutes, Georgia Southern University, Faculty Senate

Faculty Senate Minutes

No abstract provided.

Geometric Modeling Through Multiple Implicit Functions, Yiwen Ju

McKelvey School of Engineering Graduate Student Theses & Dissertations

Implicit representations have become a dominant paradigm in computational settings ranging from learning-based geometry generation to advanced manufacturing. While treating geometry as the level set of a black-box function provides significant modeling flexibility, converting these representations into explicit surface meshes remains a major challenge. Standard volumetric extraction methods are fundamentally designed for smooth manifolds and therefore struggle to capture sharp geometric features such as creases, corners, and non-manifold junctions that are critical for high-fidelity industrial design and engineering tasks. Many of these intricate features arise from modeling multiple implicit functions. Examples include Constructive Solid Geometry (CSG), material interfaces, and more …

Spartan Daily, January 29, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 4

Artificial Intelligence In Higher Education, Opportunities, And Challenges: A Review, Sharifa Alblooshi

All Works

Artificial intelligence (AI) is a growing force of change in higher education, providing assistance to students, teachers, and administrators in teaching, learning, and administration. As AI technologies advance rapidly, they present a combination of significant opportunities and complex challenges. In this study, we examine the role of AI in higher education, highlighting both its positive and negative impacts, as well as current policy gaps and issues arising from its deployment. The literature on the topic was reviewed to determine how AI decisively impacts teaching and learning, the role of AI in assessments and academic integrity, as well as ethics, psychological …

The Impact Of Ai-Powered Mobile Money System On Supply Chain: Multi-Cases From Smes In The Global South, Mostafa Mohamad, Michael Nii Laryeafio, Ebimoboere Koroye, Derick Nyame, Samuel Ayertey, Adelina Emini

All Works

This study explores the effects of adopting an artificial intelligence (AI)-powered mobile money system (AI-MMS) on supply chain operations among small and medium-sized enter-prises (SMEs) in the Global South. The authors developed a new version of Rogers’ Diffusion of Innovation model (DoI) that considers the geopolitical context and environmental fac-tors, including regulatory framework, trust, risk and complexity, to help understand how AI-MMS can enhance transactional efficiency in SMEs and bridge the financial inclusion gap. Using qualitative methods, we conducted 40 semi-structured interviews with SME owners in Abuja, Lagos, Kaduna, Kano and Port Harcourt and found that AI-MMS enhanced their logistics …

A High-Resolution Daily Precipitation Fusion Framework Integrating Radar, Satellite, And Nwp Data Using Machine Learning Over South Korea, Hyoju Park, Hiroyuki Miyazaki, Menas Kafatos, Seung Hee Kim, Yangwon Lee

Institute for ECHO Articles and Research

Accurate precipitation mapping is essential for effective disaster management; however, individual radar, satellite, and numerical weather prediction products often struggle in the topographically complex terrain of South Korea. This study proposes a high-resolution (~500 m) daily precipitation fusion framework that integrates Korea Meteorological Administration (KMA) radar, Global Precipitation Measurement (GPM) Integrated Multi-Satellite Retrievals for GPM (IMERG), and Local Data Assimilation and Prediction System (LDAPS) data. The framework employs a Random Forest model augmented with a monthly Empirical Cumulative Distribution Function (ECDF) correction. Auxiliary predictors are incorporated to enhance physical interpretability and stability, including terrain attributes to represent orographic effects, land-cover …

An Application-Based Ontological Knowledge Base Of Medications To Support Health Literacy And Adherence For The Consumer Population: An Aging Population Use Case, Clifford Chen, Muhammad Amith, Kirk Roberts, Rebecca Mauldin, Renata Komalasari, Cui Tao

Faculty, Staff and Student Publications

No abstract provided.

Modelling Land Use Land Cover Change In Banyumas Regency Using Remote Sensing Data For Tourism Policy Evaluation, Revi Hernina, Arif Wicaksono, Adi Wibowo, Astrid Damayanti

Jurnal Geografi Lingkungan Tropik (Journal of Geography of Tropical Environments)

Tourism is essentially a geographical phenomenon, encompassing the movement and flow of people and spatial distribution patterns relating to land use consumption. The impacts of tourism on LUCC must track and monitor regrading effected to environment and human side. For decades, Banyumas Regency has been known for its famous tourist destinations such Baturaden District and numerous waterfalls. However, the development of tourism infrastructures within its vicinity has sparked complaints from communities, particularly damaged roads and decreasing tourist visits. From environmental perspective, excessive tourism development might cause decreasing natural carrying capacity. Therefore, to provide deeper analysis regarding the current tourism development, …

A Strengths, Weaknesses, Opportunities, And Threats (Swot) Analysis Of Chatgpt In Academic Help-Seeking, Fan Yang

International Journal of Teaching and Learning in Higher Education

This study explores the use of ChatGPT as a help-seeking tool in educational contexts, examining both its potential benefits and costs through a SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis. The purpose is to provide a comprehensive understanding of the various internal and external factors that either promote or hinder the use of ChatGPT for academic help-seeking. The strengths of ChatGPT, such as its 24/7 availability to provide immediate responses, non-judgmental tone, and the ability to provide personalized help based on specific prompts, position itself as a valuable resource for help-seekers. However, the low quality of the responses generated by …

Seizing The "Organic" Moment: Cuba's Agricultural Crossroads And Certified Organic Export Potential, Wesley J. Hevia, Michael T. Olexa, Thomas T. Ankersen, William A. Messina Jr.

Florida Journal of International Law

Cuba has been referred to as "the world's first national experiment in sustainable agriculture." Given the critical shortages in chemical inputs to Cuba's agricultural sector following the loss of Soviet economic support and subsidization, this may well be a fitting description. Cuba's use of the term "organic" to describe some of its agricultural production can be misleading. Not all of Cuba's "organic" products would satisfy the organic certification requirements for most developed countries. That being said, Cuba is shipping certified organic fresh citrus and citrus juices into EU markets. With proper investments and implementation of the appropriate procedures and protocols, …

Exploring Cuba's New Role In The World Economy: Paths And Perils, Wentong Zheng

Florida Journal of International Law

With the normalization of relations with the United States and other countries, Cuba is ushering in a new era with unprecedented opportunities in a globalized world. Participating in the world economy, however, is a risky proposition. It requires policymakers to carefully weigh the pros and cons of each development path and choose the one that best suits Cuba. It also requires policymakers to be prepared for the perils, both economic and legal, that may arise from Cuba's participation in the world economy. This Article explores Cuba's new role in the world economy and the perils that accompany this new role. …

The Meaning Of "Equal": Evolution Of Racial Equality In The United States, Jon L. Mills

Florida Journal of International Law

The focus of this paper is the 1954 U.S. Supreme Court case, Brown vs. Board of Education, the spark that reignited the long-time quest for racial equality and that challenged the United States to live up to its constitutionally-expressed principles. The case—and the judges and lawyers who made it happen—changed society and the law. For us, the case provides the quintessential example of how the rule of law can work in the United States to the benefit of the people. After all, the courts have the final word on the meaning of the Constitution.