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Articles 21421 - 21450 of 1103983
Full-Text Articles in Entire DC Network
Underground Space Economy: Industrial Foundation And Strategic Path Under Connotative Development Background, Rong Yi, Lina Zhang
Underground Space Economy: Industrial Foundation And Strategic Path Under Connotative Development Background, Rong Yi, Lina Zhang
Bulletin of Chinese Academy of Sciences (Chinese Version)
In the new stage of China’s urban development from large-scale incremental expansion to stock improvement and efficiency improvement, underground space, as an important land space resource, has become increasingly prominent because of its strategic value and potential. Promoting the transformation of underground space development and utilization from engineering construction orientation to system governance and comprehensive utilization is an important apprach to implement the requirements of urban connotative development and improve the efficiency of resource and space utilization. The large-scale development of underground space development and utilization drives the agglomeration and systematic development of underground space related industries, which lays a …
Development Pathways And Strategies For Enhancing Resilience Of Underground Space In China’S Megacities, Xiangsheng Chen, Dong Su, Zezhou Wu, Kaihang Han, Xingtao Lin, Xiangpeng Cao, Weibin Chen
Development Pathways And Strategies For Enhancing Resilience Of Underground Space In China’S Megacities, Xiangsheng Chen, Dong Su, Zezhou Wu, Kaihang Han, Xingtao Lin, Xiangpeng Cao, Weibin Chen
Bulletin of Chinese Academy of Sciences (Chinese Version)
As China’s urbanization enters the phase of enhancing quality and efficiency of existing assets, megacities are facing dual pressures of resource constraints and safety risks. Underground space, as a key carrier for urban resilience, holds urgent strategic significance for high-quality development. This study systematically analyzes the current status, challenges, and future trends of underground space development in China’s megacities, focusing on two core issues: “resilience enhancement of existing underground space” and “resilience-oriented development of deep underground space”. It proposes a systematic development path covering “digital base–intelligent platform–key technologies–collaborative governance”. The study emphasizes the need to comprehensively enhance the disaster prevention, …
Strategic Path For High-Quality Development Of Urban Underground Space In The Yangtze River Delta Region Under Geological Safety Constraints, Weiya Ge, Rui Wang, Yunfeng Li, Jian Hua, Yang Yang
Strategic Path For High-Quality Development Of Urban Underground Space In The Yangtze River Delta Region Under Geological Safety Constraints, Weiya Ge, Rui Wang, Yunfeng Li, Jian Hua, Yang Yang
Bulletin of Chinese Academy of Sciences (Chinese Version)
As one of China’s most dynamic economic regions, the Yangtze River Delta (YRD) has approached the upper limit of surface land development, making underground space a critical strategic resource for urban renewal, compact spatial restructuring, and resilient city construction. Nevertheless, rapid expansion of underground development, combined with increasingly tight surface constraints, has led to the superposition of multiple geological hazards, which has become a key bottleneck restricting high-quality underground space utilization in the YRD. Based on comprehensive geological safety assessments of YRD cities, this study identifies six major geological risks, namely, land subsidence, karst collapse, landslides and debris flows, mining-induced …
Suggestions On Development And Industry Layout Of Special Underground Space In Western China, Shishu Zhang, Xinjian Liu, Meng Wang, Shihan Shan, Congyan Ran, Weitao Chen, Xiaoping Zhao, Siyun Li
Suggestions On Development And Industry Layout Of Special Underground Space In Western China, Shishu Zhang, Xinjian Liu, Meng Wang, Shihan Shan, Congyan Ran, Weitao Chen, Xiaoping Zhao, Siyun Li
Bulletin of Chinese Academy of Sciences (Chinese Version)
Western China has abundant resources and takes an important strategic position. Facing the dual pressure of scarce surface space and ecological protection constraints, special underground space becomes the core carrier for releasing development potential, such as space used for energy storage, material storage, and strategic repository. This research conducts a systematic comparative analysis of the underground space function of the Eastern China and the Western China based on the differential positioning in national strategic perspective. The utilization of underground space in the eastern region focuses on urban underground infrastructure while that in the western region focuses on special underground space …
Opportunities And Development Path Of Underground Space Industry For Urban Renewal And Energy Transition, Bo Zhang, Hongzhi Yao
Opportunities And Development Path Of Underground Space Industry For Urban Renewal And Energy Transition, Bo Zhang, Hongzhi Yao
Bulletin of Chinese Academy of Sciences (Chinese Version)
Driven by the two strategic opportunities of urban renewal and energy transition, the underground space industry is set to experience a new round of development boom. This study focuses on the improvement and efficiency enhancement of underground space during the urban renewal process and the utilization of underground space resource for the new energy system construction, and sorts out the key development directions of the industry. Based on the layout principle of “tailoring measures to local conditions and cities”, and in combination with the social and economic conditions and resource endowment of each region across the country, differentiated regional industrial …
Study And Reflection On Undergroundization Of Critical Infrastructure In Megacities From Perspective Of National Strategy, Kaiguo Jia, Baohua Huang, Lina Ye, Tengfei Guo, Rong Yi
Study And Reflection On Undergroundization Of Critical Infrastructure In Megacities From Perspective Of National Strategy, Kaiguo Jia, Baohua Huang, Lina Ye, Tengfei Guo, Rong Yi
Bulletin of Chinese Academy of Sciences (Chinese Version)
Critical infrastructures are vital strategic resources, directly impacting national security and the operation of economy and society. Twenty-two megacities and large cities in China, due to the concentration of resources and poorly concealed distribution of critical infrastructure, face multiple risks such as warfare attack, natural disaster, and facilitiy aging. Incorporating the undergroundization of critical infrastructure into national strategy is an imperative choice for national security, resilient city, and high-quality growth. International practices have proven the advantages of underground development in terms of protection and space optimization. During the 15th Five-Year Plan period, it is recommended to adopt strategies such as …
Practice And Multidimensional-Coupling Planning Methods Of Underground Space Utilization Of Megalopolis, Xiaodong Shi, Kejie Wu, Yiting Zhao
Practice And Multidimensional-Coupling Planning Methods Of Underground Space Utilization Of Megalopolis, Xiaodong Shi, Kejie Wu, Yiting Zhao
Bulletin of Chinese Academy of Sciences (Chinese Version)
As megacities enter a phase of stock improvement as well as intensive and efficient development, underground space planning has evolved from an engineering issue into a strategic topic concerning territorial security, resource allocation efficiency, and urban resilience. The establishment of a clear hierarchical underground space planning system and the improvement of underground space control methods are the important prerequisites for ensuring the sustainable utilization of underground space resources. In line with the territorial spatial planning system, the systematic planning and control methods have been explored from the perspective of strictly adhering to the ecological bottom line, coordinating functional facilities, and …
Strategic Research On Rebco High-Temperature Superconducting Tapes, Tianping Ying, Dongliang Wang, Pengtao Yang, Lin Zhao, Zhongtang Xu, Ziyi Liu, Chao Yao, Yanwei Ma, Xingjiang Zhou, Jinguang Cheng, Zhong Fang
Strategic Research On Rebco High-Temperature Superconducting Tapes, Tianping Ying, Dongliang Wang, Pengtao Yang, Lin Zhao, Zhongtang Xu, Ziyi Liu, Chao Yao, Yanwei Ma, Xingjiang Zhou, Jinguang Cheng, Zhong Fang
Bulletin of Chinese Academy of Sciences (Chinese Version)
High-temperature superconducting materials, represented by REBCO (REBa2Cu3O7-δ, where RE denotes rare-earth elements), are of significant strategic importance in fields such as energy, healthcare, and large-scale scientific facilities due to their excellent performance in the liquid nitrogen temperature range. However, they still face severe challenges in long-tape uniformity, production cost, and engineering reliability. Future development must shift toward a “material-processing-application” collaborative innovation model, aiming at enhancing flux pinning, optimizing the interfaces and mechanical properties of the multilayer structure, and integrating scalable and intelligent fabrication technologies to promote the low-cost and stable production of high-performance tapes. This study analyzes the core application …
Opportunities And Challenges In Synthetic Biology For Manufacture Of Bulk Chemicals, Xiaolin Shen, Qipeng Yuan
Opportunities And Challenges In Synthetic Biology For Manufacture Of Bulk Chemicals, Xiaolin Shen, Qipeng Yuan
Bulletin of Chinese Academy of Sciences (Chinese Version)
Traditional chemical manufacturing, reliant on fossil resources, meets material demands but faces challenges such as resource depletion, environmental pollution, and carbon emissions. This underscores the urgent need for a shift towards green and sustainable production methods. Biomanufacturing, which uses renewable resources to produce chemicals, offers a promising pathway for the chemical industry’s green transition. In recent years, biomanufacturing has emerged as a key area of global attention. Through synthetic biology, bulk chemicals like 1,3-propanediol have been successfully produced. Nevertheless, biomanufacturing of bulk chemicals still faces significant challenges, including high costs, low efficiency, and limited scalability. This is particularly true for …
Promoting Water Security Of South-To-North Water Diversion Project For National Water Network, Quanfa Zhang, Guihua Liu, Chesheng Zhan, Xiaobo Ren
Promoting Water Security Of South-To-North Water Diversion Project For National Water Network, Quanfa Zhang, Guihua Liu, Chesheng Zhan, Xiaobo Ren
Bulletin of Chinese Academy of Sciences (Chinese Version)
The South-to-North Water Diversion Project is a crucial infrastructure initiative aiming at optimizing nation-wide distribution of water resources, meanwhile fostering sustainable economic and social development, and ensuring the well-being of the people. The project, with its extensive scope and high technical complexity, particularly in the middle and west routes located in biodiversity hotspots such as the Qinling Mountains and the Qinghai-Xizang Plateau, may alter local microclimates, potentially triggering meteorological disasters such as droughts, thunderstorms, and hail, along with secondary hazards. The implementation of the project may also disrupt the local hydrological conditions, disturb the balance of the existing atmospheric-vegetation-soil system, …
Doc 2026-09 Sapc Report On Credit For Prior Learning, University Of Dayton. Student Academic Policies Committee
Doc 2026-09 Sapc Report On Credit For Prior Learning, University Of Dayton. Student Academic Policies Committee
Senate Documents
SAPC Report on Credit for Prior Learning
Unraveling Patch Size Effects In Vision Transformers: Adversarial Robustness In Hyperspectral Image Classification, Shashi Kiran Chandrappa, Sidike Paheding, Abel A. Reyes-Angulo
Unraveling Patch Size Effects In Vision Transformers: Adversarial Robustness In Hyperspectral Image Classification, Shashi Kiran Chandrappa, Sidike Paheding, Abel A. Reyes-Angulo
Michigan Tech Publications
Highlights: This work investigates the effect of spatial patch size on the classification accuracy and adversarial robustness of Vision Transformer-based architectures for hyperspectral image analysis. What are the main findings? Smaller patch sizes generally exhibit stronger adversarial robustness while maintaining comparable clean classification performance. Larger patch sizes tend to reduce robustness by increasing sensitivity to localized adversarial perturbations, with some dataset-dependent variations. What are the implications of the main findings? Spatial patch size is an important design consideration when applying Vision Transformers to hyperspectral image classification tasks. The findings provide practical guidance for informed patch-size selection in robust, deployment-aware transformer-based …
Project Score Program Manual, M. Barnard, T. Johnson, A. Ford-Wade, M. Godfrey, C. Compretta, E. Dehon, S. Nasruddin, B. Wade, W. Sparkmon, M. Presley, A. Jones-White, W. Qualen
Project Score Program Manual, M. Barnard, T. Johnson, A. Ford-Wade, M. Godfrey, C. Compretta, E. Dehon, S. Nasruddin, B. Wade, W. Sparkmon, M. Presley, A. Jones-White, W. Qualen
Faculty and Student Publications
Project SCORE (student-centered outcomes research experience) is an NIH-funded year-long informal public health education program and mentored research experience utilizing a youth participatory action research (YPAR) approach and near-peer mentors (NPMs) to increase science engagement, interest in college participation, and contribute to a diverse and community-engaged health sciences pipeline.
Human Microglia In Brain Assembloids Display Region-Specific Diversity And Respond To Hyperexcitable Neurons Carrying, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A Deming, Yue Shu, Akila D Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C Skarnes, Zhong-Yin Zhang, Jean-Christophe Rochet, Long-Jun Wu, Yang Yang
Human Microglia In Brain Assembloids Display Region-Specific Diversity And Respond To Hyperexcitable Neurons Carrying, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A Deming, Yue Shu, Akila D Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C Skarnes, Zhong-Yin Zhang, Jean-Christophe Rochet, Long-Jun Wu, Yang Yang
Faculty Research 2026
Microglia critically shape neuronal circuit development and function, yet their region-specific properties and roles in distinct circuits of the human brain remain poorly understood. In this study, we generated region-specific brain organoids (cortical, striatal, and midbrain), each integrated with human microglia, to fill this critical gap. Single-cell RNA sequencing uncovered six distinct microglial subtypes exhibiting unique regional signatures, including a subtype highly enriched for the GABAB receptor gene within striatal organoids. To investigate the contributions of microglia to neural circuitry, we created microglia-incorporated midbrain-striatal assembloids, modeling a core circuit node for many neuropsychiatric disorders, including autism. Using chemogenetics to …
Human Microglia In Brain Assembloids Display Region-Specific Diversity And Respond To Hyperexcitable Neurons Carrying, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A Deming, Yue Shu, Akila D Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C Skarnes, Zhong-Yin Zhang, Jean-Christophe Rochet, Long-Jun Wu, Yang Yang
Human Microglia In Brain Assembloids Display Region-Specific Diversity And Respond To Hyperexcitable Neurons Carrying, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A Deming, Yue Shu, Akila D Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C Skarnes, Zhong-Yin Zhang, Jean-Christophe Rochet, Long-Jun Wu, Yang Yang
Faculty Research 2026
Microglia critically shape neuronal circuit development and function, yet their region-specific properties and roles in distinct circuits of the human brain remain poorly understood. In this study, we generated region-specific brain organoids (cortical, striatal, and midbrain), each integrated with human microglia, to fill this critical gap. Single-cell RNA sequencing uncovered six distinct microglial subtypes exhibiting unique regional signatures, including a subtype highly enriched for the GABAB receptor gene within striatal organoids. To investigate the contributions of microglia to neural circuitry, we created microglia-incorporated midbrain-striatal assembloids, modeling a core circuit node for many neuropsychiatric disorders, including autism. Using chemogenetics to …
D. The Michael Hofmann Seismic Sections -Part A, Michael H. Hofmann
D. The Michael Hofmann Seismic Sections -Part A, Michael H. Hofmann
1980 Flathead Lake Seismic Survey
A description of the process for constructing the full-length seismic sections from sets of scans of the paper field records made in the early 2000s by then PhD candidate Michael Hofmann. Images of the full seismic sections follow the narrative by Robert W. Lankston. This set of images relates to those lines labeled on the track map in Figure 4C of the Kogan (1981) thesis.
Digital Twin Enabled Robot Collision Detection Using Time Series Forecasting, Fadi El Kalach, Mojaba A. Farahani, Philip Samaha, Thorsten Wuest, Ramy Harik
Digital Twin Enabled Robot Collision Detection Using Time Series Forecasting, Fadi El Kalach, Mojaba A. Farahani, Philip Samaha, Thorsten Wuest, Ramy Harik
Faculty Publications
The advent of Industry 4.0 has reshaped modern manufacturing, driven by breakthroughs in cutting-edge technologies. A key example is the widespread deployment of sensors, which capture and transmit large volumes of operational data. This data surge has fueled the development of advanced Artificial Intelligence (AI) applications, enhancing manufacturing intelligence and efficiency. A key enabler of such intelligence is Time-Series Forecasting (TSF), which leverages historical data to predict future trends and events, thereby providing actionable insights for proactive decision-making. In parallel, Digital Twin (DT) technology has gained significant prominence due to its capacity for bidirectional communication with physical manufacturing systems, enabling …
Approaching Lower Bound Of Lattice Thermal Conductivity By Simultaneously Suppressing Diagonal And Off-Diagonal Phonon Contributions, Alejandro David Rodriguez, Riccardo Rurali, Changpeng Lin, Joshua Ojih, Mohammed Al-Fahdi, G. Jeffrey Snyder, Ming Hu
Approaching Lower Bound Of Lattice Thermal Conductivity By Simultaneously Suppressing Diagonal And Off-Diagonal Phonon Contributions, Alejandro David Rodriguez, Riccardo Rurali, Changpeng Lin, Joshua Ojih, Mohammed Al-Fahdi, G. Jeffrey Snyder, Ming Hu
Faculty Publications
Pushing the intrinsic lattice thermal conductivity (LTC) in crystalline materials to lower bounds is crucial for fundamental materials research towards emerging technologies including thermoelectric energy conversion and thermal management in both hypersonic aircraft and next-generation turbine systems. However, in the ultralow LTC regime ( < 1 Wm-1K-1), the competition between propagative (particle-like) and coherent phonons—arising from off-diagonal components—poses a significant challenge in further reducing LTC. We perform quantitative analysis of 4700 materials using density functional theory (DFT), spanning all crystallographic groups, to elucidate the interplay between diagonal and off-diagonal phonon contributions. We identify a critical balance between these transport mechanisms, where intermediate phonon lifetimes ( ~ 1 ps) and slow group velocities ( ~ 1 km/s) collectively suppress both contributions, enabling ultralow LTC. Results from a large dataset of 31,058 structures by machine learning models strongly resemble the DFT trends of two-channel phonon transport. Leveraging these models, we screen 25,882 additional materials and confirm their properties with DFT, identifying 12 candidates with ultralow room-temperature LTC—including a record-low value of 0.132 Wm-1K-1. Our large-scale analysis reveals fundamental insights into dual-channel phonon transport, enabling rational design of ultralow LTC materials and accelerating the discovery of advanced phononic crystals with tailored thermal transport properties.
Psychological Safety And Prosocial Rule Breaking Within Leader–Member Exchanges In A State Government Agency, Larry Standfield
Psychological Safety And Prosocial Rule Breaking Within Leader–Member Exchanges In A State Government Agency, Larry Standfield
Walden Dissertations and Doctoral Studies
Psychological safety is often insufficiently supported in organizations, leading to strained leader-member exchanges (LMXs), reduced employee well-being, and diminished overall organizational performance. Government agency leaders need to understand this concern as a primary indicator of job satisfaction and organizational effectiveness. The purpose of this qualitative descriptive study was to explore how employees of a state government agency described leader support of psychological safety and prosocial rule breaking in their LMXs and how these LMX exchanges influenced their psychological safety and organizational performance. Psychosocial safety climate theory and LMX theory provided the grounding for this study. The participants consisted of 10 …
Fsec Meeting Minutes February 20, 2026, University Of Rhode Island Faculty Senate
Fsec Meeting Minutes February 20, 2026, University Of Rhode Island Faculty Senate
Faculty Senate Executive Committee Minutes
No abstract provided.
The Role Of 15-Minute Cities In Promoting Sustainable Urban Development: A Stakeholder-Centered Project Management Approach, Pamela O. Nkwantabisah
The Role Of 15-Minute Cities In Promoting Sustainable Urban Development: A Stakeholder-Centered Project Management Approach, Pamela O. Nkwantabisah
Harrisburg University Dissertations and Theses
The 15-minute city is an innovative urban planning approach that aims to enhance sustainability, accessibility, and quality of life by placing essential services within a 15-minute walk or cycle radius. Despite its popularity globally, the majority of projects fail to realize their objective due to ineffective stakeholder engagement, competing priorities, and inadequate communication throughout the project procedure. This study addresses the urgent problem of limited stakeholder involvement in 15-minute city planning and implementation. The purpose of the study is to determine challenges of stakeholder engagement and develop a stakeholder-centric approach rooted in project management best practices. Guided by the Stakeholder …
Exploring The Impact Of Team Culture In High-Pressure Jobs, Such As Investment Banking And Consulting, And How Project Management Can Be Applied, Mayavathi Lal
Harrisburg University Dissertations and Theses
Toxic team cultures remain a pressing issue in high-pressure environments such as investment banking and consulting, where long hours, and hierarchical norms often undermine employee well-being and compromise project delivery. Previous studies have documented how workplace stress, exclusionary leadership, and cultural rigidity fuel burnout and turnover. However, limited research has explicitly examined these cultural dynamics through the lens of project management frameworks such as resource management, stakeholder engagement, and agile practices. This study employs a qualitative research approach by leveraging semi-structured interviews with analysts and associates, to capture the lived experiences of culture and its impact on team coordination and …
Quality Improvement Project: Effectiveness Of Staff Education On Fall Prevention, Theresa Oahre Okoyomo
Quality Improvement Project: Effectiveness Of Staff Education On Fall Prevention, Theresa Oahre Okoyomo
Doctor of Nursing Practice Projects
Falls increase injury and mortality rates and decrease patients' quality of life. Hospital falls also incur enormous financial burdens on hospitals. In 2008, the Centers for Medicare & Medicaid Services (CMS) stopped reimbursing hospitals for fall-related injuries. The problem addressed in this quality improvement project was staff confidence in fall prevention and hospital fall rates. The purpose is to improve staff confidence and reduce fall rates by 95 % within six weeks. The 2025 CDC/STEADI Algorithm for Fall Risk Screening, Assessment, and Intervention was the program of choice because it aligns with the hospital's fall-prevention policy. This project design is …
Analytical Review Of Current Educational Public Policy For California Department Of Education Common Core Curriculum Guidelines Pertaining To Law-Related Education For Grades K–12, Aubray Mcpherson
Walden Dissertations and Doctoral Studies
The problem addressed in this study was the lack of a mandated statewide law-related education (LRE) requirement within the California K–12 curriculum. Existing research linked structured LRE exposure to greater civic knowledge, stronger legal understanding, increased social responsibility, and reduced delinquency risk among disadvantaged youth. However, a gap exists due to the absence of integrated qualitative analyses combining prior LRE research with stakeholder perceptions. The purpose of this qualitative study was to examine the potential social, emotional, and economic implications associated with implementing a statewide LRE public policy. Guided by the conceptual framework consisting of new public administration and the …
A Holistic Modelling Framework For Functionally Safe Software Architectures In Embedded Control Systems, Thomas Barth
A Holistic Modelling Framework For Functionally Safe Software Architectures In Embedded Control Systems, Thomas Barth
Doctoral
Embedded control systems are integral to most modern electrified products and an essential backbone of ongoing digitalisation [1]. In this context, these systems increasingly perform safety-critical functions where failures can lead to severe personal injury, environmental damage, or significant economic loss [2]. Consequently, they fall more often within the scope of regulation such as IEC 61508 and its derivatives [3]. At the same time, driven by hardware evolution and market demands, embedded control systems continue to grow in both integration density and functional complexity [4]. These demands necessitate structured development methods that balance compliance with cost-efficiency and development agility. A …
Journey To A Heart Safe Community, Mary Mccormack, Carole Zarcone, Kendra Hoepper, Dorothy Veron
Journey To A Heart Safe Community, Mary Mccormack, Carole Zarcone, Kendra Hoepper, Dorothy Veron
Creating Healthy Work Environments (CHWE)
The sudden loss of life is a traumatic event inflicting devastating and lasting impacts on families and communities. It has been estimated that more than 350,000 episodes of out-of-hospital cardiac arrest (OHCA) occur annually in the United States (Virani et al., 2021); however, being that there is no nationwide mandatory reporting system, this number may be a gross underrepresentation of reality. The majority of OHCA occur residential homes and in the community setting. Survival rates are heavily dependent upon provision of immediate cardiopulmonary resuscitation (CPR) and defibrillation with neurologic damage occurring within 5 minutes (Brooks et al., 2022).
Unfortunately, the …
Human Microglia In Brain Assembloids Display Region-Specific Diversity And Respond To Hyperexcitable Neurons Carrying Scn2a Mutation, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A Deming, Yue Shu, Akila D Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C Skarnes, Zhong-Yin Zhang, Jean-Christophe Rochet, Long-Jun Wu, Yang Yang
Human Microglia In Brain Assembloids Display Region-Specific Diversity And Respond To Hyperexcitable Neurons Carrying Scn2a Mutation, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A Deming, Yue Shu, Akila D Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C Skarnes, Zhong-Yin Zhang, Jean-Christophe Rochet, Long-Jun Wu, Yang Yang
The Brown Foundation: Institute of Molecular Medicine
Microglia critically shape neuronal circuit development and function, yet their region-specific properties and roles in distinct circuits of the human brain remain poorly understood. In this study, we generated region-specific brain organoids (cortical, striatal, and midbrain), each integrated with human microglia, to fill this critical gap. Single-cell RNA sequencing uncovered six distinct microglial subtypes exhibiting unique regional signatures, including a subtype highly enriched for the GABAB receptor gene within striatal organoids. To investigate the contributions of microglia to neural circuitry, we created microglia-incorporated midbrain-striatal assembloids, modeling a core circuit node for many neuropsychiatric disorders, including autism. Using chemogenetics to activate …
From Waitlist To Activation: Exploring Patient Barriers And Team Interactions In Kidney Transplant Readiness, Judith I. Eguzoikpe
From Waitlist To Activation: Exploring Patient Barriers And Team Interactions In Kidney Transplant Readiness, Judith I. Eguzoikpe
Harrisburg University Dissertations and Theses
Kidney transplant candidates frequently experience prolonged inactive waitlist status due to incomplete readiness requirements, yet limited understanding exists regarding how patient barriers and team interactions intersect to influence activation timelines. This transcendental-phenomenological study explored how patient barriers and team dynamics contribute to delays in kidney transplant readiness, guided by Team Theory. Semi-structured interviews were conducted with 16 participants (8 patients, 8 healthcare professionals) between December 2025 and February 2026. Data were analyzed using systematic phenomenological methods to identify patterns that address patient barriers, team interaction effects, and the teamwork improvements needed for earlier activation. Five interconnected themes emerged: Navigating a …
Enhancing Risk Governance In Agile Settings: Toward An Integrated Agile Framework For Strategic Risk Alignment, Mohammed Shaik
Enhancing Risk Governance In Agile Settings: Toward An Integrated Agile Framework For Strategic Risk Alignment, Mohammed Shaik
Harrisburg University Dissertations and Theses
Agile project management is widely used in dynamic and regulated environments because of its adaptability and iterative delivery (Beck et al., 2001). However, Agile teams often rely on informal risk practices that may limit visibility into enterprise-level risks (Stare, 2014). In contrast, Enterprise Risk Management (ERM) frameworks provide structured oversight aligned with strategic objectives (Committee of Sponsoring Organizations of the Treadway Commission [COSO], 2017), yet they are frequently viewed as fast-paced project settings. This misalignment creates governance challenges for organizations operating in complex environments.
This study examined how Agile practices can be integrated with ERM frameworks to strengthen strategic risk …
The Role Of Stakeholder Management In The Adaptive Reuse Of Historic Buildings: Balancing Social, Economic, And Community Interests, Karina G. Iavarone
The Role Of Stakeholder Management In The Adaptive Reuse Of Historic Buildings: Balancing Social, Economic, And Community Interests, Karina G. Iavarone
Harrisburg University Dissertations and Theses
The adaptive reuse of historic buildings has emerged as a vital strategy for sustainable urban development. While such projects can preserve cultural heritage, revitalize communities, and stimulate economic growth, they often face significant challenges due to competing stakeholder priorities. The central problem addressed in this study is the lack of effective stakeholder management in adaptive reuse initiatives, which can result in project delays, inflated costs, and outcomes that overlook social sustainability.
The purpose of this qualitative, descriptive study was to explore how stakeholder management practices influence the success of adaptive reuse projects by balancing social, economic, and community interests. Three …