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Integral Boundary Layer Methods In Python, Malachi Joseph Edland Aug 2021

Integral Boundary Layer Methods In Python, Malachi Joseph Edland

Master's Theses

This thesis presents a modern approach to two Integral Boundary Layer methods implemented in the Python programming language. This work is based on two 2D boundary layer methods: Thwaites' method for laminar boundary layer flows and Head's method for turbulent boundary layer flows. Several novel enhancements improve the quality and usability of the results. These improvements include: a common ordinary differential equation (ODE) integration framework that generalizes computational implementations of Integral Boundary Layer methods; the use of a dense output Runge-Kutta ODE solver that allows for querying of simulation results at any point with accuracy to the same order as …


High Voltage Dc-Dc Converter Design For Submarine Application, Oscar Ambriz Aug 2021

High Voltage Dc-Dc Converter Design For Submarine Application, Oscar Ambriz

Master's Theses

In this work a proof of concept for a step-down DC-DC converter used in a high voltage submarine application is presented. The purpose of the converter is to step down a 5000V-6000V input to a 24V output which can serve as an input to a submarine sensor. The completed system consists of two stages where the first stage is an unregulated switched capacitor converter to step down the initial input to a voltage range more appropriate for the selected second stage. The second stage is a regulated flyback converter topology which regulates the final output to the desired 24V. Performance …


Parent Involvement And Student Achievement: Effects Of Indirect Parent Involvement On Student Achievement In Mathematics, Sarah Ann Myers Aug 2021

Parent Involvement And Student Achievement: Effects Of Indirect Parent Involvement On Student Achievement In Mathematics, Sarah Ann Myers

Electronic Theses, Projects, and Dissertations

Parents are often seen through a deficit lens despite all that they do for their children. Parents want to do all they can to help their children be successful in school and in math specifically. This can be challenging due to the increasing pressure for students to perform well in math, the current methods for teaching math, and the math work students bring home. This quantitative study investigates how home-based parent involvement strategies predict student's math grade point average (GPA). The data in this study was derived from 23,503 participants within the High School Longitudinal Study of 2009 (HSLS:09). With …


Implementing Technology Into Classroom Instructional Practices, Mark B. Christopher Aug 2021

Implementing Technology Into Classroom Instructional Practices, Mark B. Christopher

College of Education

As the presence of technology increases within classrooms, teachers are evolving in their instruction; however, teacher utilization of technology within classroom instructional practice is not consistently applied for the educational benefit of students. The acquisition and implementation of classroom technology across rural and non-rural schools are not equitable due to a lack of financial resources and infrastructure (Sundeen & Sundeen, 2013). This mixed-method research study, with an emphasis on quantitative data, utilized a Likert-scale survey examining the thoughts, perceptions, and opinions of 667 K-12 teachers on technology access, support, and professional development along with a questionnaire of nine elementary and …


Effects Of Professional Development Delivered In A Blended Format On General Education Elementary Teachers' Knowledge Of The Response To Intervention Process, Laura Jensen Aug 2021

Effects Of Professional Development Delivered In A Blended Format On General Education Elementary Teachers' Knowledge Of The Response To Intervention Process, Laura Jensen

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Research within the last decade suggests that in-service general education elementary teachers’ understanding of and skills in administering Response to Intervention (RtI) practices are limited. A review of literature revealed a shortage of professional publications investigating the effects of RtI training for these teachers on their knowledge and skills. This project examined the effects of professional development delivered in a blended format on elementary general education teachers’ knowledge of the response to intervention process. Participants included female general education teachers with a current teaching assignment in grades one or two with a range of teaching experience from preschool through sixth …


Teaching In The Digital Age: Creating A Student-Centered Classroom, Becca Huber-Jackson Aug 2021

Teaching In The Digital Age: Creating A Student-Centered Classroom, Becca Huber-Jackson

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

This portfolio compiles the work of the author during her time as a student in the Master of Second Language Teaching (MSLT) program at Utah State University (USU). It highlights her personal pedagogy as well as provides supporting research. The different components of this portfolio are separated into two sections: teaching perspectives and research perspectives.

In the teaching perspectives section, she introduces her desired professional environment, outlines her teaching philosophy statement, and provides an analysis based on teaching observations. Research perspectives consist of two research papers and an annotated bibliography written throughout the course of the program that support the …


The Effects Of Ceria Loading On Three-Way Catalysts For Passive Scr Operation, Calvin R. Thomas, Josh A. Pihl, Vitaly Y. Prikhodko, Michelle K. Kidder, Jochen A. Lauterbach, Todd J. Toops Aug 2021

The Effects Of Ceria Loading On Three-Way Catalysts For Passive Scr Operation, Calvin R. Thomas, Josh A. Pihl, Vitaly Y. Prikhodko, Michelle K. Kidder, Jochen A. Lauterbach, Todd J. Toops

Faculty Publications

Passive SCR systems, which employ both a three-way catalyst and SCR catalyst, are effective for the reduction of nitrogen oxide (NOx) emissions from lean burn gasoline engines. However, questions remain regarding the effect of three-way catalyst formulations on their performance in these systems. Here, Pd/CeOx/Al2O3 catalysts with variable CeOx loading were synthesized, characterized, and evaluated to determine the effects of CeOx on catalyst performance. While a small amount of ceria was beneficial for promoting essential reactions, excess ceria was detrimental due to the increase in oxygen storage capacity. Additionally, insights into potential reaction pathways for NH3 production were determined.


Microstructure And Microchemistry Of Laser Welds Of Irradiated Austenitic Steels, Yaqiao Wu, Megha Dubey Aug 2021

Microstructure And Microchemistry Of Laser Welds Of Irradiated Austenitic Steels, Yaqiao Wu, Megha Dubey

Materials Science and Engineering Faculty Publications and Presentations

This article investigates the integrity of laser welds on neutron irradiated, He-containing steels. Life extension of the current fleet of light water reactors could necessitate repair of cracks on irreplaceable internal components, but heat input of weld repairs exacerbates the problem by initiating He-induced cracking. Laser welding is a promising low-heat-input technology thought to limit the extent of He-induced cracking. In this study, we produce laser welds in a hot cell on AISI 304L stainless steel plates previously irradiated in the Experimental Breeder Reactor (EBR)-II. We select a systematic set of three specimens spanning fluences ~1–28 displacements per atom (dpa) …


N Y State Dent J August-September 2021 Aug 2021

N Y State Dent J August-September 2021

The New York State Dental Journal

The New York State Dental Journal (NYSDJ) is produced by the New York State Dental Association (NYSDA) six times a year, in January, March, April, July, September and November. Each issue features clinical and scientific articles written by researchers and practitioners from around the globe and is subject to review by a panel of specialists convened by the Editor.

Issues include cover and feature articles alongside regular columns with regional news impacting the New York membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.


Polycyclic Aromatic Hydrocarbons And The Microbiomes Of Two Benthic Species, Samantha Ells Aug 2021

Polycyclic Aromatic Hydrocarbons And The Microbiomes Of Two Benthic Species, Samantha Ells

Master's Theses

The presence of oil has been shown to affect the microbiomes of the water column, sediments, and organisms, both by altering the diversity and the composition of those microbial communities. If the microbiome is altered it may no longer provide benefits to its host organism, impacting its ability to survive. Thus, it is important to understand the effects of large-scale contamination events including the Deepwater Horizon oil spill. This study set out to examine the effects of oil exposure on the microbiome of two benthic species, southern flounder (Paralichthys lethostigma) and eastern oysters (Crassostrea virginica) to further understand the effects …


Exploring The Influence Of Diurnal Forcing On Tidal Inlet Exchange And The Impact On The Movement Of Oxygen Depleted Waters In The Mississippi Sound And Bight Region, Courtney Bouchard Aug 2021

Exploring The Influence Of Diurnal Forcing On Tidal Inlet Exchange And The Impact On The Movement Of Oxygen Depleted Waters In The Mississippi Sound And Bight Region, Courtney Bouchard

Master's Theses

A small yet notable hypoxic event manifests east of the Birdfoot Delta in the Mississippi Sound and Bight (MSAB). The shallow shelf environment of the MSAB is affected by a host of complex physical interactions and separating the influences of each process is difficult to accomplish with in-situ data alone. A physical model using high-resolution atmospheric forcing has been developed which provides insights into the physical interactions in this coastal marine system heavily influenced by freshwater plumes and diurnal wind forcing. Twin experiments using a high temporal (hourly) and spatial (0.01 deg) resolution meteorological analysis product, along with a temporally …


Population Parameter Estimation And Stable Isotope Analysis Of Gulf Sturgeon (Acipenser Oxyrinchus Desotoi) In The Pascagoula River, Alfonso Cohuo Aug 2021

Population Parameter Estimation And Stable Isotope Analysis Of Gulf Sturgeon (Acipenser Oxyrinchus Desotoi) In The Pascagoula River, Alfonso Cohuo

Master's Theses

Gulf Sturgeon (GS), Acipenser oxyrinchus desotoi, are a threatened, anadromous fish species in the northern Gulf of Mexico. Their range is from the Pearl River, LA, in the west to the Suwannee River, FL, in the east with a longitudinal divide at Mobile Bay, AL, creating a western population unit (WPU) and an eastern population unit (EPU). Sturgeon belonging to the WPU exhibit lower abundances, higher mortality rates, and are overall less studied than their EPU counterparts. Notable data gaps for the WPU includes the absence of recent population parameter estimations and confirmed feeding habitat. My thesis aims to …


Spatial And Seasonal Patterns Of Above- And Belowground Vegetation Biomass And Potential Drivers In The Pascagoula River Delta, Ms, Evan Grimes Aug 2021

Spatial And Seasonal Patterns Of Above- And Belowground Vegetation Biomass And Potential Drivers In The Pascagoula River Delta, Ms, Evan Grimes

Master's Theses

Coastal wetlands provide a valuable wealth of services to the greater coastal ecosystem and human communities. However, threats such as sea level rise and conservation projects, such as freshwater diversions, have the potential to alter coastal wetlands in different ways. In this thesis, I describe the effects of inundation and nitrogen on vegetation productivity using a field-sampling approach and an in situ controlled mesocosm experiment, called a marsh organ. The West Channel of the Pascagoula River contained significantly higher belowground biomass than the East Channel, which is more anthropogenically modified. Vertical distribution of belowground biomass did not strongly vary between …


Assessing The Rates Of Post-Depositional Change Within 2004 Indian Ocean Sediments: Implications For Long-Term Records Of Paleotsunamis, Lillian Pearson Aug 2021

Assessing The Rates Of Post-Depositional Change Within 2004 Indian Ocean Sediments: Implications For Long-Term Records Of Paleotsunamis, Lillian Pearson

Master's Theses

Foraminifera are commonly used to examine patterns of tsunami inundation occurring over centennial to millennial timescales, but the impacts of post-depositional change on geologic reconstructions are unknown. In Sumatra, the taphonomic character (i.e., test surface condition) of a foraminifer can deteriorate over time, rendering them unidentifiable, and even dissolve them entirely. Here I investigate the rates of post-depositional change of foraminiferal assemblages found within the 2004 Indian Ocean Tsunami (IOT) deposit over a 15-year time interval in Aceh, Indonesia in a vegetated open coastal plain (Site 1: Pulot) and an unvegetated protected coastal cave (Site 2). I identified two zones …


Design, Synthesis, And Characterization Of Glycodendrons Through Small Molecule And Linear Polymer Models, Molly Jones Aug 2021

Design, Synthesis, And Characterization Of Glycodendrons Through Small Molecule And Linear Polymer Models, Molly Jones

Master's Theses

This thesis focuses on the design, synthesis, and characterization of glycopolymer-dendron thiol-ene coupling reactions with the long-term goal of increasing biocompatibility of near infrared (NIR) fluorophores for bioimaging applications. A design of experiments was used with small molecule model compounds to determine the parameters for successful thiol-ene click reactions that would lead to success of more complicated amphipathic polymer-polymer coupling reactions. The first chapter provides an introductory overview of the importance and applications of glycopolymers, bioimaging, and Janus dendrimersomes. The second chapter presents the synthetic methods for creating a glucose-functionalized glycopolymer with an acrylamide backbone, the exploration of thiol-ene coupling …


Effect Of Additional Weight On Stability Of Human Squat Exercise, Jose De Jesus Galarza Lozano Aug 2021

Effect Of Additional Weight On Stability Of Human Squat Exercise, Jose De Jesus Galarza Lozano

Theses and Dissertations

The main focus of the study is to analyze the stability of the squat exercise. The squat is a common exercise that persons do for exercise. The study analyze the time series of the normal component of the ground reaction forces and each coordinate of the center of pressure. Theses time series are used to estimate the Lyapunov Exponents using Rosenstein method. MATLAB from Mathworks is used to calculate the graphs and program the methods. We compare this result with the literature and previous experiments. This work gives more information relating the safety of the squat exercise when …


Fabrication And Characterization Of Polyvinylidene Fluoride Nanofibers For Energy Harvesting Applications, Jui Vitthal Kharade Aug 2021

Fabrication And Characterization Of Polyvinylidene Fluoride Nanofibers For Energy Harvesting Applications, Jui Vitthal Kharade

Theses and Dissertations

Miniaturization of portable devices demand a power source that does not require recharging or replacement. Piezoelectric energy harvesters are devices that harvest mechanical energy from environment and convert it into electrical energy thus being an ideal candidate for replacing batteries in small devices. Objective of this thesis is to fabricate an energy harvester with efficient energy conversion. In this thesis, the effect of fabricating mechanisms, solvents, and composites on polyvinylidene nanofibers are analysed in order to improve the piezoelectric response of the nanofibers. These nanofibers are then used for fabricating an energy harvester. The energy harvester is implemented in a …


The Role Of Sense Of Community On Knowledge Sharing Behavior In Makerspaces, Eduardo Jose Millet Aug 2021

The Role Of Sense Of Community On Knowledge Sharing Behavior In Makerspaces, Eduardo Jose Millet

Theses and Dissertations

Using the Sense of Community Theory and the Knowledge Sharing Behavior this study explores the motivation of members of makerspaces to share technical and non-technical knowledge in this type of creative spaces. In makerspaces, individuals are expected to share what they know with others to solve design and fabrication problems. Most of the sharing occurs when experienced makers transfer knowledge to the novice makers. This behavior is what motivates this dissertation. Unlike traditional knowledge sharing that happens in formal organizations, makerspace participants engage in the knowledge sharing behavior differently; they share in an informal manner creating value for makerspaces and …


In-Situ Alloying Of Cucrfenitial High Entropy Alloy Using Spark Plasma Sintering, Yash P. Patil Aug 2021

In-Situ Alloying Of Cucrfenitial High Entropy Alloy Using Spark Plasma Sintering, Yash P. Patil

Theses and Dissertations

Primary objective of this research was to study the correlation between energy parameters (temperature, time and pressure) of spark plasma sintering (SPS) and design/structural properties (uniform distribution of elements, sever lattice distortion, density), indirectly proving consolidation of a stable High-entropy alloy (HEA) that consists of minimum of five elements. Therefore, powders of five principal elements (CuCrFeNiTi) and one minor element (Al) in near equimolar ratios were used for HEA consolidation using SPS but without mechanical alloying. Overall results demonstrated that the HEA was not generated using heterogenous solution of CuCrFeNiTiAl using SPS. This suggests that the mechanical alloying of CuCrFeNiTiAl …


Production And Characterization Of Polyurethane Fibers By Forcespinning Method And Incorporation Of Luminiscense Nanoparticles, Sunanda Kumar Saha Aug 2021

Production And Characterization Of Polyurethane Fibers By Forcespinning Method And Incorporation Of Luminiscense Nanoparticles, Sunanda Kumar Saha

Theses and Dissertations

In this work, Polyurethane (PU) fine fiber nonwoven mats are generated using the Forcespinning® method. A detailed study focusing on the effect of PU concentration within solutions of N, N Dimethylformamide and the effect of relative humidity (RH) on fiber average diameter and fiber yield is presented. Solutions were prepared with 4 different concentrations, 14, 15, 16 and 17 wt% of PU. It was observed that as concentration of PU increases, average diameter shows a tendency to increase. Production of fibers with RH varying from X to X was analyzed. It was shown that higher RH is convenient for PU …


Vortex-Oriented Ferroelectric Domains In Snte/Pbte Monolayer Lateral Heterostructures, Kai Chang, John W. D. Villanova, Jing-Rong Ji, Souvik Das, Felix Kuster, Salvador Barraza-Lopez, Paolo Sessi, Stuart S. P. Parkin Aug 2021

Vortex-Oriented Ferroelectric Domains In Snte/Pbte Monolayer Lateral Heterostructures, Kai Chang, John W. D. Villanova, Jing-Rong Ji, Souvik Das, Felix Kuster, Salvador Barraza-Lopez, Paolo Sessi, Stuart S. P. Parkin

Physics Faculty Publications and Presentations

Heterostructures formed from interfaces between materials with complementary properties often display unconventional physics. Of especial interest are heterostructures formed with ferroelectric materials. These are mostly formed by combining thin layers in vertical stacks. Here the first in situ molecular beam epitaxial growth and scanning tunneling microscopy characterization of atomically sharp lateral heterostructures between a ferroelectric SnTe monolayer and a paraelectric PbTe monolayer are reported. The bias voltage dependence of the apparent heights of SnTe and PbTe monolayers, which are closely related to the type-II band alignment of the heterostructure, is investigated. Remarkably, it is discovered that the ferroelectric domains in …


Milk Exosomes: Nature's Abundant Nanoplatform For Theranostic Applications, Benilde Adriano, Nycol Cotto, Neeraj Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu Aug 2021

Milk Exosomes: Nature's Abundant Nanoplatform For Theranostic Applications, Benilde Adriano, Nycol Cotto, Neeraj Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications

Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles. Exosomes have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, and disseminating long-distance intercellular communications in various biological processes. Among various cell-line or biological fluid derived exosomes, milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications. To be an effective delivery carrier for their clinical translation, exosomes must inbuilt loading, release, targeting, and imaging/tracking characteristics. Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus the …


Knn Based Piezo-Triboelectric Lead-Free Hybrid Energy Films, Abu Masa Abdullah, Muhtasim Ul Karim Sadaf, Farzana Tasnim, Horacio Vasquez, Karen Lozano, M. Jasim Uddin Aug 2021

Knn Based Piezo-Triboelectric Lead-Free Hybrid Energy Films, Abu Masa Abdullah, Muhtasim Ul Karim Sadaf, Farzana Tasnim, Horacio Vasquez, Karen Lozano, M. Jasim Uddin

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

In recent times, the triboelectric and piezoelectric effects have garnered significant attention towards developing advanced material composites for energy harvesting and sensory applications. In this work, potassium sodium niobate (KNN) based energy films (EF) have been developed to utilize mechanical energy while simultaneously taking advantage of triboelectric and piezoelectric mechanisms. The KNN particles were synthesized using a wet ball milling technique and then incorporated into a polyvinylidene difluoride (PVDF) matrix together with addition of multi wall carbon nanotubes (MWCNT). The film was used to develop a piezoelectric nanogenerator (PENG) fitted with copper electrodes. The piezoelectric output of the film was …


Differences In Erosion Rates And Elevation Among Natural, Living And Hardened Shorelines In Mississippi, And Alabama, Brittany Juneau Aug 2021

Differences In Erosion Rates And Elevation Among Natural, Living And Hardened Shorelines In Mississippi, And Alabama, Brittany Juneau

Honors Theses

Shoreline erosion is a phenomenon that currently threatens both natural ecosystems and human settlements along the coast. With trends showing gradual sea level rise as a result of climate change, erosion is becoming an increasing threat to these communities. This research aims to provide more insight into the relationship between shoreline morphology and three shoreline protection techniques: natural marsh, living shoreline, and hardened structures. Six sites along the Alabama and Mississippi coast that had all three shoreline types were evaluated to determine what the average erosion rate and slope was for each shoreline. Erosion rates were calculated by image analysis …


Unveiling Global Roles Of G-Quadruplexes And G4-22 In Human Genetics, Ruth Barros De Paula Aug 2021

Unveiling Global Roles Of G-Quadruplexes And G4-22 In Human Genetics, Ruth Barros De Paula

Dissertations and Theses (Open Access)

G-quadruplexes are non-B DNA structures formed by four or more runs of repeated guanines that confer unique features to living organism’s genomes. These sequences are enriched in regulatory regions, such as promoters and 5’ UTRs, and have distinct regulatory roles in both health and disease states. Even though previous studies showed the impact of G4 in gene expression, none of them summarized the location-specific effect of G4. Also, there is no broad understanding about the most common G4 repeat in the human genome, named here as G4-22, and how it links to the evolution of mammals and their biology. In …


Development Of Quantitative Molecular Photoacoustic Imaging For Noninvasive Cancer Diagnostics, Cayla Zandbergen Aug 2021

Development Of Quantitative Molecular Photoacoustic Imaging For Noninvasive Cancer Diagnostics, Cayla Zandbergen

Dissertations and Theses (Open Access)

Traditional diagnostic imaging provides clinicians with anatomical information that guides both diagnosis and treatment planning; however, once a tumor has progressed enough to be visible, it has often reached an advanced stage. Molecular imaging techniques allow for real-time visualization of chemical and biological processes via imaging of specific biomarkers, which can facilitate detection of malignancies before they become visible. One biomarker of interest is blood oxygen saturation (SO2) due to its correlation with hypoxia, which is associated with increased tumor malignancy; some studies have also established SO2 as an independent biomarker of disease progression. Additionally, because cancerous …


Understanding The Pathogenesis Of Renal Medullary Carcinoma, Melinda Soeung Aug 2021

Understanding The Pathogenesis Of Renal Medullary Carcinoma, Melinda Soeung

Dissertations and Theses (Open Access)

Renal medullary carcinoma (RMC) is a lethal cancer that predominantly affects young individuals with sickle cell trait (SCT). It is not currently understood why RMC only affects certain individuals with SCT. We found that patients with RMC more frequently participated in high-intensity exercise than matched controls. Using mouse models of SCT, we demonstrated the significant increase of renal hypoxia in the right kidney following high- but not moderate-intensity exercise. We also demonstrated in cell culture studies that SMARCB1 is ubiquitinated for proteasome-mediated degradation in hypoxia, and the re-expression of SMARCB1 leads to compromised proliferation in renal cells specifically in the …


Dissecting The Mechanisms Of Venetoclax Resistance In Myelodysplastic Syndromes, Shuaitong Chen Aug 2021

Dissecting The Mechanisms Of Venetoclax Resistance In Myelodysplastic Syndromes, Shuaitong Chen

Dissertations and Theses (Open Access)

Myelodysplastic syndromes (MDS) are a class of heterogeneous clonal hematopoietic disorders. The current standard of care for MDS is the hypomethylating agent (HMA)-based therapy. However, only 50 percent of the patients respond, with transient effects and no approved second-line treatment options after their diseases progress to acute myeloid leukemia (AML). The mechanisms that govern HMA failure are unknown. Recently, we unveiled that MDS are maintained and propagated by two different immunophenotypically distinct hierarchical cellular organizations of MDS hematopoietic stem and progenitor cells (HSPCs) through the upregulation of specific survival pathways. This finding allowed us to potentially stratify MDS patients into …


Dissecting Tumor Heterogeneity In Lung Cancer, Aparna Padhye Aug 2021

Dissecting Tumor Heterogeneity In Lung Cancer, Aparna Padhye

Dissertations and Theses (Open Access)

Lung cancer is a heterogeneous disease composed of genetically and phenotypically distinct tumor cells as well as a heterogeneous microenvironment consisting of non-cancer cells and extracellular matrix. Constant interactions among these components ultimately leads to a complex tumor tissue that is ever evolving and poses a therapeutic challenge for sustained benefit. Strategies for targeting lung cancers are largely guided by the genetic alterations identified in the tumor specimens. However, in order to gain a better understanding of lung cancer progression and develop effective treatment modalities, studying tumor in context of its microenvironment is crucial. The first aim of this project …


Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment Of Genital Hpv Tumors, Gloria Sierra Aug 2021

Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment Of Genital Hpv Tumors, Gloria Sierra

Dissertations and Theses (Open Access)

Human Papillomavirus (HPV) induced cancers continue to affect millions of women worldwide, with the five year survival rate hovering just under 60% in some demographics. Therefore there is an unmet need to develop effective, yet, easily administered therapies to treat established HPV genital lesions. Even though immune checkpoint therapy (ICT) is a promising treatment option in some HPV+ cancers, the high cost and associated toxicities are still major concerns for their widespread application. HPV cancers are textbook candidates for therapeutic vaccination intervention because they’re driven by the expression of viral oncoproteins E6 and E7, which serve as ideal tumor specific …