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Jmasm 55: Matlab Algorithms And Source Codes Of 'Cbnet' Function For Univariate Time Series Modeling With Neural Networks (Matlab), Cagatay Bal, Serdar Demir Sep 2021

Jmasm 55: Matlab Algorithms And Source Codes Of 'Cbnet' Function For Univariate Time Series Modeling With Neural Networks (Matlab), Cagatay Bal, Serdar Demir

Journal of Modern Applied Statistical Methods

Artificial Neural Networks (ANN) can be designed as a nonparametric tool for time series modeling. MATLAB serves as a powerful environment for ANN modeling. Although Neural Network Time Series Tool (ntstool) is useful for modeling time series, more detailed functions could be more useful in order to get more detailed and comprehensive analysis results. For these purposes, cbnet function with properties such as input lag generator, step-ahead forecaster, trial-error based network selection strategy, alternative network selection with various performance measure and global repetition feature to obtain more alternative network has been developed, and MATLAB algorithms and source codes has been …


Supporting Big Data Research At Case Western Reserve University, Jen Green, Ben Gorham, Roger Zender, Lee Zickel, Em Dragowsky Sep 2021

Supporting Big Data Research At Case Western Reserve University, Jen Green, Ben Gorham, Roger Zender, Lee Zickel, Em Dragowsky

Researchers, Instructors, & Staff Scholarship

This report is an investigation of the research practices of faculty and research staff who utilize or support data science or big data methodologies at Case Western Reserve University (CWRU). The study was conducted by librarians and library staff within the Kelvin Smith Library (KSL) in collaboration with staff within CWRU University Technology ([U]tech), and was part of national selection of parallel studies occurring at public and private academic institutions throughout North America.


September 28, 2021 Ereporter, University Of Alabama At Birmingham Sep 2021

September 28, 2021 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


The Ephb2 Receptor Uses Homotypic, Head-To-Tail Interactions Within Its Ectodomain As An Autoinhibitory Control Mechanism, Yan Xu, Dorothea Robev, Nayanendu Saha, Bingcheng Wang, Matthew B. Dalva, Kai Xu, Juha P. Himanen, Dimitar B. Nikolov Sep 2021

The Ephb2 Receptor Uses Homotypic, Head-To-Tail Interactions Within Its Ectodomain As An Autoinhibitory Control Mechanism, Yan Xu, Dorothea Robev, Nayanendu Saha, Bingcheng Wang, Matthew B. Dalva, Kai Xu, Juha P. Himanen, Dimitar B. Nikolov

Department of Neuroscience Faculty Papers

The Eph receptor tyrosine kinases and their ephrin ligands direct axon pathfinding and neuronal cell migration, as well as mediate many other cell–cell communication events. Their dysfunctional signaling has been shown to lead to various diseases, including cancer. The Ephs and ephrins both localize to the plasma membrane and, upon cell–cell contact, form extensive signaling assemblies at the contact sites. The Ephs and the ephrins are divided into A and B subclasses based on their sequence conservation and affinities for each other. The molecular details of Eph–ephrin recognition have been previously revealed and it has been documented that ephrin binding …


Three-Dimensional Geometric Modeling Of Tomato Morphology Based On Representation Of Few Parameters, Liu Ying, Wang Man-Sheng, Qu Wen-Juan, Ma Hai-Le, Pan Zhong-Li, Jiang Qun-Hui Sep 2021

Three-Dimensional Geometric Modeling Of Tomato Morphology Based On Representation Of Few Parameters, Liu Ying, Wang Man-Sheng, Qu Wen-Juan, Ma Hai-Le, Pan Zhong-Li, Jiang Qun-Hui

Food and Machinery

Objective: This study aimed to realizing the three-dimensional visual simulation of the morphological structure of tomatoes. Methods: A new tomato shape equation was derived, which took the radius as a function and included size parameters and shape description coefficients. By calculating the geometric model description coefficients (a, b, c1, c2) based on the measured values of the main size parameters of the tomatoes, a three-dimensional geometric model of tomatoes was developed and established their correlation with the weight and height of the tomatoes. Moreover, the accuracy of the model was verified by comparing the measured and …


Evolution Of Powder, Master Batch And Film Structure Of Starch In The Process Of Extrusion Blowing, Zhu Jie, Cui Bo, Gao Wei, Wang Kun, Jia Si-Qiang Sep 2021

Evolution Of Powder, Master Batch And Film Structure Of Starch In The Process Of Extrusion Blowing, Zhu Jie, Cui Bo, Gao Wei, Wang Kun, Jia Si-Qiang

Food and Machinery

Objective: In order to study the structure evolution of three states of powder, masterbatch and film of starch during extrusion blowing. Methods: Using hydroxypropyl distarch phosphate as raw material, starch film was prepared by extrusion blow molding. Using Fourier Infrared Spectroscopy-Attenuated Total Reflectance (FTIR-ATR), X-ray Diffraction (XRD), Thermal Stability Analyzer (TGA), Gel Permeation Chromatography (GPC) and other technical means, crystal structure, thermal stability and molecular structure changes of the starch were analyzed in powder state, masterbatch state and film state. Results: After extrusion, the starch crystal form changed from powder state A to masterbatch state and film state V, and …


Study On The Variation Of Volatile Components Of Ready-To-Eat Pacific Saury (Cololabis Saira) During Processing, Wu Li-Xiang, Zhang Wen, Tong Qiu-Xia, Ni Li Sep 2021

Study On The Variation Of Volatile Components Of Ready-To-Eat Pacific Saury (Cololabis Saira) During Processing, Wu Li-Xiang, Zhang Wen, Tong Qiu-Xia, Ni Li

Food and Machinery

Objective: Headspace solid-phasemicroextraction combined with gas chromatography-mass spectrometry (HS-SPME-GC-MS) was used to separate and identify the volatile components of Pacific saury. Methods: The odor threshold was used to calculate the relative odor activity value (ROAV) to determine the critical aroma component of the samples under different processing stages. Principal components analysis and variable importance for the projection (VIP) values were used to determine characteristic flavor compounds at different stages. Results: The results showed that 63 volatile components were detected in Pacific saury samples, and aldehydes were the main flavor substances. (E, Z)-2,6-nonadienal, Octanal, Methional, (Z)-4-heptenal, (E, E)-2,6 nonadienal and 1-octene-3 …


Comparison Of Emulsification Cross-Linking Method And Solvent Evaporating Technique For Preparation Of Microsphere Encapsulating Lemon Essential Oil, Chang Xiang-Yu, Li Hui-Qing, Cao Ye-Xia, Zhang Xin-Rui Sep 2021

Comparison Of Emulsification Cross-Linking Method And Solvent Evaporating Technique For Preparation Of Microsphere Encapsulating Lemon Essential Oil, Chang Xiang-Yu, Li Hui-Qing, Cao Ye-Xia, Zhang Xin-Rui

Food and Machinery

Objective: In order to overcome the disadvantageous volatility and degradability of essential oil, microsphere was prepared with polymer as wall material to encapsulate essential oil for sustaining release. Methods: The Lemon essential oil was extracted from the steam distillation, the essential oil microspheres were prepared by emulsion cross-linking method taking sodium alginate/gelatin used as the wall material, and solvent evaporating technique Polylactic acid-Glycolic Acid copolymer (PLGA) as the wall material. The properties of the microspheres were compared by yield rate, entrapment efficiency and slow release behavior, and their thermal stability was tested by thermogravimetric analysis. Results: The diameter of the …


Pulsed Vacuum Drying Characteristics And Multi-Objective Optimization Of Poria Cubes, Zhang Wei-Peng, Chen Hao-Ran, Fan Xiao-Zhi, Xiao Hong-Wei, Zheng Zhi-An, Ju Hao-Yu Sep 2021

Pulsed Vacuum Drying Characteristics And Multi-Objective Optimization Of Poria Cubes, Zhang Wei-Peng, Chen Hao-Ran, Fan Xiao-Zhi, Xiao Hong-Wei, Zheng Zhi-An, Ju Hao-Yu

Food and Machinery

Objective: In order to explore the effects of drying temperature, vacuum duration, atmospheric duration and their interactions on drying time, specific energy consumption, polysaccharide content and broken ratio of Poria cubes in pulsed vacuum drying process, so as to obtain better drying parameters and improve the drying efficiency and quality of Poria cocos cubes. Methods: the drying temperature (55~95 ℃), vacuum duration (0~20 min) and atmospheric duration (0~8 min) were selected as independent variables, and central composite design of response surface method was used to analyze the drying process; The quadratic regression model of drying time, specific energy consumption, polysaccharide …


Research On Performance Of Nh3/Co2 Cascade Refrigeration System With Variable Rotation Speed, Ye Meng-Ying, Gu Zhong, Xie Jing Sep 2021

Research On Performance Of Nh3/Co2 Cascade Refrigeration System With Variable Rotation Speed, Ye Meng-Ying, Gu Zhong, Xie Jing

Food and Machinery

Objective: This study aimed to research the influence of different rotation speed of high-temperature compressor on the performance of NH3/CO2 cascade refrigeration system under various seasons and evaporation temperature of 25 ℃. Methods: The NH3/CO2 cascade refrigeration system model was established and its reliability was verified in this paper. The relationship between the rotation speed of high-temperature compressor and the evaporation temperature, the discharge temperature, the intermediate temperature, high-temperature compressor power, cooling capacity, Coefficient of Performance (COP) of cascade refrigeration system was calculated and analyzed. Results: The relative error of the simulation model for …


Interactive System Design Of English Ordering Robot Based On Deep Coding Network, Mu Bin-Bin, Wang Ping Sep 2021

Interactive System Design Of English Ordering Robot Based On Deep Coding Network, Mu Bin-Bin, Wang Ping

Food and Machinery

Objective: This paper studies the design ideas and concepts of the emotional interaction of the ordering robot, so as to design the human-based intelligent emotional interaction method of the ordering robot. Methods: Firstly, BLSTM network was used to construct the English semantic parameter coding network, then put forward thrust type attention model, this model can extract data by means of weighting, after that, the constrained SeqGAN network architecture is designed to complete the decoding, so as to adjust the parameters of the generating device and narrow the gap between the generated ordering language and human English emotional interaction response. Results: …


Prediction Of Sugar Content In Apple Based On Near-Infrared Spectroscopy Of Ssa-Elm, Qiao Zheng-Ming, Zhan Cheng Sep 2021

Prediction Of Sugar Content In Apple Based On Near-Infrared Spectroscopy Of Ssa-Elm, Qiao Zheng-Ming, Zhan Cheng

Food and Machinery

Objective: In order to eliminate a large amount of redundant information in near infrared spectrum, and improve the accuracy of sugar degree in apple of the prediction model, a method for fast and non-destructive testing of the sugar content of apples was established. Methods: A prediction model of apple sugar content based on wavelet packet transform and bottle ascidian algorithm was proposed. Firstly, according to the characteristics of apple spectral data with high and complex dimensions, the spectral data was reduced, and the characteristic wavelength screening method was determined by comparing the results of full band and partial least squares …


Nondestructive Detection Of Moisture Content In Fresh Fruit Corn Based On Hyperspectral Technology, Lian Meng-Ru, Zhang Shu-Juan, Ren Rui, Chi Jiang-Tao, Mu Bing-Yu, Sun Shuang-Shuang Sep 2021

Nondestructive Detection Of Moisture Content In Fresh Fruit Corn Based On Hyperspectral Technology, Lian Meng-Ru, Zhang Shu-Juan, Ren Rui, Chi Jiang-Tao, Mu Bing-Yu, Sun Shuang-Shuang

Food and Machinery

Objective: In order to realize the fast and accurate prediction of moisture content of fresh fruit corn. Methods: Hyperspectral technology was used to collect and extract the spectral data of fresh fruit and corn. The effects to the accuracy of model were studied by comparing the data from Standard Normalized Variate (SNV), Multiplicative Scatter Correction (MSC), Savitzky-Golay smooth (SG) and Moving Average (MA), etc. MSC was selected for preprocessing. Based on the data preprocessed by MSC, successive projections algorithm (SPA), Competitive Adaptive Reweighted Sampling(CARS)and random frog (RF) were selected to optimize the characteristic wavelength for the prediction of moisture content …


Research On Separation System Of Potato Processing Raw Materials Based On Machine Vision, Li Ming, Wang Run-Tao, Jiang Wei Sep 2021

Research On Separation System Of Potato Processing Raw Materials Based On Machine Vision, Li Ming, Wang Run-Tao, Jiang Wei

Food and Machinery

Objective: Taking raw potatoes as the objects, an automatic sorting system was designed to realize the automatic identification of potato under the set standard, which provided technical support for the processing and production of potato products. Methods: The control flows of sorting system and sorting algorithms were constructed. Images of two sides of a potato were acquired automatically through automatic transmission, machine vision acquisition and suction pressure turning. The image restoration algorithms were used to eliminate motion blur and the detection algorithms of area ratio, length diameter and bulge were designed to detect potatoes deformity, germination and size of potatoes. …


Effects Of Ultra-Fine Green Tea Powder On Noodle Quality And Optimization Of Green Tea Noodle Formula, Cai Xi-Xi, Chen Xu, Chen Xuan, Chen Meng-Shi, Gao Xue-Ling, Wang Shao-Yun Sep 2021

Effects Of Ultra-Fine Green Tea Powder On Noodle Quality And Optimization Of Green Tea Noodle Formula, Cai Xi-Xi, Chen Xu, Chen Xuan, Chen Meng-Shi, Gao Xue-Ling, Wang Shao-Yun

Food and Machinery

Objective: The study aimed to explore the effect of ultra-fine green-tea powder on the quality of noodles, and develop a kind of noodles rich in superfine powder of green tea. Methods: The effects of ultra-fine green tea powder on the texture characteristics, water migration and sensory flavor of noodles were comprehensively analyzed, and the formula of ultra-fine green tea noodles was optimized by response surface design. Results: The addition of ultra-fine green-tea powder had adverse effect on the cooking characteristics of noodles. Adding 2%~4% superfine green tea powder could improve the sensory and texture properties of noodles, including hardness, chewability …


Analysis Of Edible Areca Products Based On Electronic Tongue Technology, Chao Yu-Zhou, Liu Yi, Zhao Zhi-You, Xia Yan-Bin Sep 2021

Analysis Of Edible Areca Products Based On Electronic Tongue Technology, Chao Yu-Zhou, Liu Yi, Zhao Zhi-You, Xia Yan-Bin

Food and Machinery

Objective: Electronic tongue technology was used to analyze the taste of edible areca and compared with sensory evaluation to provide a more objective and accurate evaluation method. Methods: The taste of 12 different areca products from 8 enterprises was analyzed using electronic tongue, sensory evaluation, and multivariate statistical methods. Results: There were significant differences in the areca taste index between different brands; the samples were divided into three groups by principal component analysis, factor analysis and cluster analysis, and each cluster had its unique taste characteristics. Combined with the electronic tongue and sensory evaluation, the results were consistent except for …


Effects Of The Addition Of Pumpkin Powder On The Quality Characteristics Of Fresh Noodles, Tan Yu-Heng, Li Liang-Yi, Ma Yan, Luo Ao-Jie, Hu Han, Zhou Wen-Hua Sep 2021

Effects Of The Addition Of Pumpkin Powder On The Quality Characteristics Of Fresh Noodles, Tan Yu-Heng, Li Liang-Yi, Ma Yan, Luo Ao-Jie, Hu Han, Zhou Wen-Hua

Food and Machinery

Objective: This study focuses on the effect of different additions of pumpkin powder on the quality characteristics of fresh pumpkin noodles. Methods: The color, cooking characteristics, texture characteristics and sensory evaluation scores of fresh noodles with different additions of pumpkin powder were determined, and the comprehensive evaluation was carried out by correlation analysis and principal component analysis. Results: With the increase in the amount of pumpkin powder added, the brightness of the fresh noodles decreased and the color changed from bright yellow to orange yellow. The 5% pumpkin powder fresh noodles had the lowest breakage rate and loss rate, and …


Research Progress On Management Of Athletes’ Dietary Nutrition, Jing Xi-Min Sep 2021

Research Progress On Management Of Athletes’ Dietary Nutrition, Jing Xi-Min

Food and Machinery

By systematically selecting, combing and analyzing the published papers on the literature retrieval websites, such as SCI、CNKI, etc., this review summarized the current research progress of foreign and domestic sports dietary nutrition of athletes, and explored the metabolic laws and nutrition management strategies of energy, carbohydrates, protein and fat, in order to provide some references for theoretical development of sports nutrition and the research and manufacturing of sports nutrition food in China.


Hunan Cold Chain: Cold Chain Traceability System Based On Blockchain, Pan Hui-Ping, Li Bao-An, Lu Xue-Qiang, Jiang Yang, Li Guo-Lin, Zhang Le Sep 2021

Hunan Cold Chain: Cold Chain Traceability System Based On Blockchain, Pan Hui-Ping, Li Bao-An, Lu Xue-Qiang, Jiang Yang, Li Guo-Lin, Zhang Le

Food and Machinery

Objective: In order to solve the problem that traditional traceability system cannot guarantee the reliability and integrity of data, and strengthen the protection and monitoring of cold chain food. Methods: Based on the trustworthiness and traceability of blockchain technology, the Hunan Provincial Market Supervision and Administration Bureau had built a traceability system for the Hunan Cold Chain. Hunan Cold Chain adopt a storage method that could read and write separation, and used a cache system to improve the efficiency of the blockchain system to read and write status data. Results: Thereby achieving data sharing in the traceability link of the …


Research Progress On The Mechanism Of Dietary Polyphenols In Improving Inflammatory Bowel Disease, Lin Peng-Cheng, Cao Jun-Han, Xie Wan-Cui Sep 2021

Research Progress On The Mechanism Of Dietary Polyphenols In Improving Inflammatory Bowel Disease, Lin Peng-Cheng, Cao Jun-Han, Xie Wan-Cui

Food and Machinery

This article summarizes the mechanism by which dietary polyphenols improve inflammatory bowel disease by regulating oxidative stress, protecting the intestinal mucosal barrier, regulating intestinal flora and metabolites, highlights the regulatory effect of dietary polyphenols on inflammatory bowel disease inflammatory signaling pathways, and prospects to the research direction of dietary polyphenols in the nutritional intervention field of inflammatory bowel disease and other diseases.


Pharmacological Effects Of Ex Vivo Mesenchymal Stem Cell Immunotherapy In Patients With Acute Kidney Injury And Underlying Systemic Inflammation, Madhav Swaminathan, Nelson Kopyt, Mohamed G. Atta, Jai Radhakrishnan, Kausik Umanath, Sunny Nguyen, Brian O'Rourke, Ashley Allen, Natalie Vaninov, Arno Tilles, Elizabeth Lapointe, Andrew Blair, Chris Gemmiti, Brian Miller, Biju Parekkadan, Rita N. Barcia Sep 2021

Pharmacological Effects Of Ex Vivo Mesenchymal Stem Cell Immunotherapy In Patients With Acute Kidney Injury And Underlying Systemic Inflammation, Madhav Swaminathan, Nelson Kopyt, Mohamed G. Atta, Jai Radhakrishnan, Kausik Umanath, Sunny Nguyen, Brian O'Rourke, Ashley Allen, Natalie Vaninov, Arno Tilles, Elizabeth Lapointe, Andrew Blair, Chris Gemmiti, Brian Miller, Biju Parekkadan, Rita N. Barcia

Nephrology Articles

Mesenchymal stem cells (MSCs) have natural immunoregulatory functions that have been explored for medicinal use as a cell therapy with limited success. A phase Ib study was conducted to evaluate the safety and immunoregulatory mechanism of action of MSCs using a novel ex vivo product (SBI-101) to preserve cell activity in patients with severe acute kidney injury. Pharmacological data demonstrated MSC-secreted factor activity that was associated with anti-inflammatory signatures in the molecular and cellular profiling of patient blood. Systems biology analysis captured multicompartment effects consistent with immune reprogramming and kidney tissue repair. Although the study was not powered for clinical …


Delivery Optimization And Evaluation Of Biomechanics Of An Injectable Nucleus Pulposus Replacement Device, Zachary Rustin Brown Sep 2021

Delivery Optimization And Evaluation Of Biomechanics Of An Injectable Nucleus Pulposus Replacement Device, Zachary Rustin Brown

Theses and Dissertations

Lower back pain effects up to 80% of people at some point in their life, a majority of cases being the result of degenerative disc disease. Treatment options for degenerative disc disease are limited, jumping from physical therapy to major spinal fusion and total disc replacement surgery with little to no approaches in between. Furthermore, surgical treatments have not shown to be more effective than conservative treatments and reducing pain and disability over the long term. Hydrogels have shown promise as a potential nucleus pulposus replacement device. Their properties are controllable and can be implanted into the body through minimally …


Ascending Leader, Brooks Payette Sep 2021

Ascending Leader, Brooks Payette

UNH Today Archive

No abstract provided.


Periodically Disturbing The Spatial Structure Of Biofilms Can Affect The Production Of An Essential Virulence Factor In Pseudomonas Aeruginosa, Rebecca J. Quinn, Ivana Barraza, Laura García-Diéguez, Camryn Pajon, Lauren E. Krausfeldt, Kerollos Ibrahim, Laura A. Enzinna, Morgan E. Thorn, Omar Tonsi Eldakar, Travis J. A. Craddock, Robert P. Smith Sep 2021

Periodically Disturbing The Spatial Structure Of Biofilms Can Affect The Production Of An Essential Virulence Factor In Pseudomonas Aeruginosa, Rebecca J. Quinn, Ivana Barraza, Laura García-Diéguez, Camryn Pajon, Lauren E. Krausfeldt, Kerollos Ibrahim, Laura A. Enzinna, Morgan E. Thorn, Omar Tonsi Eldakar, Travis J. A. Craddock, Robert P. Smith

Biology Faculty Articles

Understanding the environmental factors that affect the production of virulence factors has major implications in evolution and medicine. While spatial structure is important in virulence factor production, observations of this relationship have occurred in undisturbed or continuously disturbed environments. However, natural environments are subject to periodic fluctuations, including changes in physical forces, which could alter the spatial structure of bacterial populations and impact virulence factor production. Using Pseudomonas aeruginosa PA14, we periodically applied a physical force to biofilms and examined production of pyoverdine. Intermediate frequencies of disturbance reduced the amount of pyoverdine produced compared to undisturbed or frequently disturbed conditions. …


Managing The Energy Trilemma In The Philippines, Josef Teofisto T. Yap, Aaron Joseph P. Gabriola, Chrysogonus F. Herrera Sep 2021

Managing The Energy Trilemma In The Philippines, Josef Teofisto T. Yap, Aaron Joseph P. Gabriola, Chrysogonus F. Herrera

Ateneo School of Government Publications

Background

The transition to an energy mix with lower carbon emissions is hampered by the existence of the so-called Energy Trilemma. The primary consequence is a trade-off between various objectives of energy policy, e.g., equity and sustainability. This conflict can lead to policy gridlock if policymakers are unable to prioritize the goals. This paper proposes a framework and methodology to manage the trilemma by applying methods related to multi-criteria decision-making in order to assign weights to the various components of the trilemma.

Results

Following the International Energy Agency (IEA), an expanded concept of energy security is adopted and translates to …


Design And Statics Analysis Of A Novel Under-Actuated Robot Hand, Jiang Rui-Bing, Zuo Cui, Huang Long, Li Zuo-Kui, Liu Bo-Hai Sep 2021

Design And Statics Analysis Of A Novel Under-Actuated Robot Hand, Jiang Rui-Bing, Zuo Cui, Huang Long, Li Zuo-Kui, Liu Bo-Hai

Food and Machinery

Objective: Here in this study, we focus on solving the pick-and-place problem of the food packaging boxes in different positions. Methods: A novel design of under-actuated robotic hand was proposed, and two motion patterns of the robotic hand were realized based on cable-pulley transmission, which were parallel gripping and adaptive gripping between the fingers. On this basis, the statics of the robotic hand was analyzed through the principle of virtual work, and the gripping forces between the fingers were obtained. Results: The force between the fingers can ensure the effective gripping of the packaging box no matter whether the box …


Cellular And Molecular Alterations Associated With Ovarian And Renal Cancer Pathophysiology, Ravneet Kaur Chhabra Sep 2021

Cellular And Molecular Alterations Associated With Ovarian And Renal Cancer Pathophysiology, Ravneet Kaur Chhabra

USF Tampa Graduate Theses and Dissertations

Elucidating molecular alterations underlying tumor development and chemoresistance are critical to expand our understanding of the disease pathophysiology. This dissertation is focused on analyzing the cellular and molecular alterations associated with LPA-induced chemoresistance in clear cell renal cell carcinoma (ccRCC) cells and chronic iron-induced deregulation of miRNA expression in fallopian tube secretory epithelial cells (FTSECs).

Kidney cancer is one of the ten most common cancers worldwide with <15% survival rate at advanced stage (American Cancer Society). ccRCC is the most common type of kidney cancer and is described as a metabolic disease characterized by deregulated lipid metabolism leading to increased intracellular lipid droplets [9, 10]. The current molecular-targeted treatment strategies involve VEGF/VEGFR and mTOR inhibition [9, 12]. However, there are limitations to these approaches leading to the reduced efficacy and/or increased resistance in ccRCC cells [13, 14]. Therefore, it is important to decipher the factors involved in compromising the chemosensitivity in these cells.

Lysophosphatidic acid (LPA), a bioactive phospholipid, was previously reported to increase resistance against Sunitinib (VEGFR/PDGFR inhibitor) in ccRCC cells and to increase migration and invasion in various tumors [15-17]. In Chapter 3 of …


Newsroom, Georgia Southern University Sep 2021

Newsroom, Georgia Southern University

Newsroom (2006-2023)

  • Georgia Southern celebrates ‘40 Under 40’ Class of 2021


Development Of Carbon And Silicon Carbide Based Microelectrode Implantable Neural Interfaces, Chenyin Feng Sep 2021

Development Of Carbon And Silicon Carbide Based Microelectrode Implantable Neural Interfaces, Chenyin Feng

USF Tampa Graduate Theses and Dissertations

The use of neural modulation techniques to treat nervous system disorders, as well as neural recording to study brain function, continues to be of intense interest around the world. Due to the need to treat diseases such as Parkinson’s, dementia, depression and return normal function to patients suffering from nervous system damage and trauma, neural implants continue to be developed globally. One of these devices, the microelectrode implantable neural interface (mINI), has been rapidly developed, thanks to advanced semiconductor fabrication processes. However, the long-term reliability of present-day devices has still to be demonstrated and is delaying the application of this …


Metal Alloy Core-Shell Nanoparticles And Related Methods, Lauren F. Greenlee, Prashant Acharya Sep 2021

Metal Alloy Core-Shell Nanoparticles And Related Methods, Lauren F. Greenlee, Prashant Acharya

Patents Granted

Metallic nanoparticles and related methods of making and using the same are described herein. An aqueous synthesis method is used to create nanoparticle cores comprising alloys of two or more metals at varying metal:metal molar ratios. In some embodiments, the nanoparticle cores described herein form a homogeneous metal alloy. Alternatively, the nanoparticle cores form a heterogeneous metal alloy. The synthesis method can further comprise forming mixed metal oxide shells on the nanoparticle cores.