Digital Commons Network^™

Rare Variants In Kdr, Encoding Vegf Receptor 2, Are Associated With Tetralogy Of Fallot., Doris Škorić-Milosavljević, Najim Lahrouchi, Fernanda M. Bosada, Gregor Dombrowsky, Simon G. Williams, Robert Lesurf, Fleur V Y Tjong, Roddy Walsh, Ihssane El Bouchikhi, Jeroen Breckpot, Enrique Audain, Aho Ilgun, Leander Beekman, Ilham Ratbi, Alanna Strong, Maximilian Muenke, Solveig Heide, Alison M. Muir, Mariam Hababa, Laura A. Cross, Dihong Zhou, T Pastinen, German Competence Network For Congenital Heart Defects, Elaine Zackai, Samir Atmani, Karim Ouldim, Najlae Adadi, Katharina Steindl, Anita Rauch, David Brook, Anna Wilsdon, Irene Kuipers, Nico A. Blom, Barbara J. Mulder, Heather C. Mefford, Boris Keren, Pascal Joset, Paul Kruszka, Isabelle Thiffault, Sarah E. Sheppard, Amy Roberts, Elisabeth M. Lodder, Bernard D. Keavney, Sally-Ann B. Clur, Seema Mital, Marc-Philip Hitz, Vincent M. Christoffels, Alex V. Postma, Connie R. Bezzina

Manuscripts, Articles, Book Chapters and Other Papers

Purpose: Rare genetic variants in KDR, encoding the vascular endothelial growth factor receptor 2 (VEGFR2), have been reported in patients with tetralogy of Fallot (TOF). However, their role in disease causality and pathogenesis remains unclear.

Methods: We conducted exome sequencing in a familial case of TOF and large-scale genetic studies, including burden testing, in >1,500 patients with TOF. We studied gene-targeted mice and conducted cell-based assays to explore the role of KDR genetic variation in the etiology of TOF.

Results: Exome sequencing in a family with two siblings affected by TOF revealed biallelic missense variants in KDR. Studies in knock-in …

Applying Heidegger To Case Study Research In The Medical And Social Sciences, Patrick Whitehead

The Qualitative Report

In this article, I introduce an approach to the case-study method which is based on the work of German philosopher Martin Heidegger (1889-1976). Heidegger’s insights have been applied by philosophers and scholars to the social and health sciences, and this application has increased noticeably over the last decade. This article has been written so that non philosophers may benefit from Heidegger’s insights and apply them to their own research and practice. I begin with a description and overview of the shift in perspective that Heidegger has advocated, and how this shift has turned upside down the fields to which it …

Osha’S Comprehensive Failure To Protect Workers During The Covid-19 Pandemic, Nancy M. Modesitt

All Faculty Scholarship

Under the Trump Administration, the Occupational Safety and Health Administration (“OSHA”), failed to protect workers from COVID-19, which has led to deadly workplace outbreaks of the virus. OSHA’s failures began when it refused to produce legally-binding rules, known as emergency temporary standards, that would mandate the most basic step of requiring masks in the workplace to protect workers from the risks of infection on the job. In addition, while OSHA did produce non-binding guidance for employers, that guidance was unclear and fundamentally deficient in failing to require masks in all workplaces and failing to require recordkeeping that would identify potential …

Exploring Performance In Air Force Science And Technology Programs, Eric A. Plack, Jonathan D. Ritschel, Edward D. White, Clay M. Koschnick

Faculty Publications

Science and technology (S&T) programs serve an important function in the defense acquisition process as the initial phase leading to discovery and development of warfighting technology. The results of these programs impact the larger major defense acquisition programs, which integrate the technologies in subsequent phases of the life cycle. Despite this important role, little prior research has examined the performance of S&T programs. In this study, the authors investigate the impact of technological maturation as a critical success factor in Air Force S&T programs. The results suggest that S&T programs with mature technologies are more likely to experience above average …

A Systematic Review Of The Use Of St John's Wort For Smoking Cessation In Adults

Faculty, Staff and Students Publications

St. John's wort (SJW) has been researched and clinically used for treating various psychiatric disorders, including depression. Few clinical trials have studied its use in smoking cessation. This systematic review provides comprehensive evidence of the studies conducted to date. Five databases were searched for randomized controlled trials (RCTs) that evaluated the effectiveness of SJW for smoking cessation in adults. The trials included the use of SJW alone, or along with nicotine replacement therapy, chromium, or behavioral therapies. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used to report this systematic review. Overall, four RCTs met the eligibility …

Preparing Nursing Homes For A Second Wave Of Coronavirus Disease 2019 (Covid-19), A Rekha Murthy, Hilary Babcock, Et Al.

2020-Current year OA Pubs

No abstract provided.

A Human Ipsc-Derived Inducible Neuronal Model Of Niemann-Pick Disease, Type C1, Anika V Prabhu, Insung Kang, Raffaella De Pace, Christopher A Wassif, Hideji Fujiwara, Pamela Kell, Xuntian Jiang, Daniel S Ory, Juan S Bonifacino, Michael E Ward, Forbes D Porter

2020-Current year OA Pubs

BACKGROUND: Niemann-Pick disease, type C (NPC) is a childhood-onset, lethal, neurodegenerative disorder caused by autosomal recessive mutations in the genes NPC1 or NPC2 and characterized by impaired cholesterol homeostasis, a lipid essential for cellular function. Cellular cholesterol levels are tightly regulated, and mutations in either NPC1 or NPC2 lead to deficient transport and accumulation of unesterified cholesterol in the late endosome/lysosome compartment, and progressive neurodegeneration in affected individuals. Previous cell-based studies to understand the NPC cellular pathophysiology and screen for therapeutic agents have mainly used patient fibroblasts. However, these do not allow modeling the neurodegenerative aspect of NPC disease, highlighting …

Experimental Analysis Of Indoor Air Quality For Human Comfort In Vehicle Cabin / Siti Nor' Ain Mokhtar, Mokhtar Siti Nor'ain

Student Works (2020-2029)

In present time more people spend a relatively longer time inside their vehicles. However, the microenvironment of a vehicle cabin is vulnerable to exposure of air contaminants such as carbon dioxide, Carbon Dioxide (CO2) and Particulate Matter PM10 originated from the surrounding and vehicle operation. Carbon Dioxide would cause acidosis, which is particularly harmful to the cells of the brain. Even at low-to-moderate, CO2 (>800ppm) has been found to be associated with headache, fatigue, kidney failure and reduce cognitive ability in humans. Exposure to Particulate Matter10 affects the lungs and heart, leading to health complication such as nonfatal heart …

Learning To Value My Ideas And Take Control Of My Education, Kundala G. Shankar

Teaching and Learning Together in Higher Education

No abstract provided.

Virtual Piano Instruction For The College Learner, Gena Greher, Dominique Haughton, Jacob Hiser, Brandon Vaccaro

Journal of the Association for Technology in Music Instruction

This article investigates the affordability and feasibility of conducting virtual piano lessons for the college level learner. It proposes an approach that works well and requires equipment costing approximately $300 per student. We outline the pros and cons of conducting virtual piano lessons online. The main benefit is overcoming geographical distances, whereas limitations include challenges such as the instructor being able to check issues such as fingerings or dynamics. Latency is not a major problem as long as only one person is playing at any given time, as found in past work. The process of teaching and learning online requires …

Twisted Buildings: Concepts And Approaches, Amani Marmar, Sally Zouia, Sahar Ismail, Ahmad Hallik

Architecture and Planning Journal (APJ)

With the emerging of new technologies, the look for more sustainable towers appears. Through designing twisted towers, an aerodynamic and energy efficient structure can be made to reduce materials and wind loads towards it. By definition, a twisted building is one that has gradually rotating floor plates along its height. The problem here rises due to the risk of structural failure and lack of load transfer and unorganized interior function. Thus, this research aims to detect the design solutions used to execute the twisted buildings achieving stability, safety, and withstanding climatic effects. In order to accomplish the mentioned aim, the …

The Preterite, Steven Gillies

Floodwall Magazine

No abstract provided.

Long-Lasting Nanotherapeutics For The Treatment Of Eye Diseases, Qingguo Xu

Amgen Seminar Series in Chemical Engineering

Blindness represents a substantial burden to the healthcare system. However, delivering therapeutics to the eye is a challenge on multiple levels. Rapid clearance of medications in eye drops requires that they be applied frequently, but patient compliance with eye drop regimens is poor (e.g., glaucoma patients only take roughly one-half of their doses correctly). In addition, drug penetration to the back of the eye following topical administration is limited due to multiple ocular barriers. On the other hand, the blood-retinal barrier limits the delivery of drugs into the eye following systemic administration. In this talk, I will present a long-lasting …

Exploring A New Urban Strategy To Organize The Informal Settlements In Tripoli, Ayman Wehbe

Architecture and Planning Journal (APJ)

A dynamic urban form can be defined as emerging in the planning, and development of urban centers as a city where there is a defined perimeter, inside which lies a population that is self-sufficient supporting by the technologies and economy within the city fully employs the population, the services, and cultural infrastructure within the city are sufficient to supply for the population in the cities. One of the most significant driving forces of change in any urban system is population development. This randomness in growth causes an imbalance in the civil system through environmental problems on the life system that …

التخطيط الإقليمي مدخل لمواجهة المخاطر المرتبطة بالتغير المناخي لأقاليم الساحل الشمالي في مصر, Mahmoud Aly Ahmed Mohammed

Architecture and Planning Journal (APJ)

تعد التغيرات المناخية من أهم المعضلات التي تواجة العالم خاصةً في ظل القضايا الشائكة من الاحتباس الحراري وتزايد ارتفاع درجة حرارة الأرض، وذوبان الصفائح الجليدية وارتفاع منسوب مياه البحار والمحيطات، مما دفع منظمة الأمم المتحدة لإبرام إتفاقية التغيرات المناخية وبروتوكول كيوتو، اللذان يهدفان لخفض هذه الانبعاثات، وأعلنت الهيئة الحكومية الدولية المعنية بتغير المناخ أن دلتا النيل في مصر من بين المناطق الثلاث الأولى على كوكب الأرض الأكثر عرضة لارتفاع مستوى سطح البحر، وأشار تقرير البنك الدولي انه يوجد فى مصر عدة مناطق أوشكت على الغرق تشمل هذه المناطق شديدة الخطورة أجزاء من محافظات الدلتاوالإسكندرية ومحافظات البحيرة وبورسعيد ومحافظات دمياط ومحافظة …

An Exploration Of Crime Prevention Through Environmental Design (Cpted) Principles For Enhancing Safety And Security In The Design Of Adamawa State University Students’ Hostel, Mubi, Benjamin Moral, Mudashir Gafar

Architecture and Planning Journal (APJ)

People across the world face growing insecurity, violent conflict spreading and intensifying and the natural systems on which human life depends on, is in jeopardy. Also, today the security condition of student hostel has become one of the major challenges facing Nigerian institutions, with continual media coverage of the state of insecurity of the students’ hostel, level of theft, burglary, abductions, and kidnappings. This research set out to proffer solutions to the rising insecurity challenges in the students’ hostel. This was achieved through the development of a framework from CPTED, on architectural strategies used to deter crime from thriving in …

Potentials Of Containers In Creating Modular Architectural Spaces, Karim Al-Khatib, Jinan Makkawi, Ali Kobeissi

Architecture and Planning Journal (APJ)

Containers are currently considered as one of the inventive trends of framing architectural objects. Container architecture is defined as the type of architecture that is characterised by the usage of steel containers as a structural elements and architectural envelope that can be presented as a part of architecture or a function that an activity can happen in it. Due to the specific dimensions that the container has, architects tend to use it to obtain modularity in their projects and the modular design strategies refer to using the containers as a standard unit to carry out the process, these containers are …

Power Of Cantilever Design In The Contemporary Architecture, Karen Hassan Beydoun, Jana Hussein, Ahmad Salame

Architecture and Planning Journal (APJ)

Cantilever is a structural form that extends horizontally and is supported by one end and free on the other while the load is distributed equally, initiated by the use of bridges and balconies in the buildings. The power of Cantilevers with its different designs is spreading throughout the world via various perspectives since it increases the ability of design creativity and gives proper solutions. However, from that point forward, a research gap that has been found missing relating the structural challenges and how it affects the design and the decisions taken by the clients/ owners paying budgets on such type …

Understanding Informed Design Through Trade-Off Decisions With An Empirically-Based Protocol For Students And Design Educators, Molly H. Goldstein, Robin S. Adams, Senay Purzer

Journal of Pre-College Engineering Education Research (J-PEER)

Trade-off decisions, which necessitate striking a balance between two or more desirable but competing features, are a crucial part of design practice. However, they are known to be difficult for student designers to make. While designers, educators, and researchers have numerous methods to assess the quality of design artifacts, these methods are not necessarily easy to use, nor do they indicate design competency. Moreover, they are not grounded in a definition of engineering design. The objectives of this study were twofold. First, we developed a protocol to depict design artifact quality through the lens of design trade-off decisions. We aimed …

Enhancing Engineering Identity Among Boys Of Color, Jerrod Henderson, Virginia Snodgrass Rangel, James Holly Jr, Rick Greer, Mariam Manuel

Journal of Pre-College Engineering Education Research (J-PEER)

Black and Brown men continue to be underrepresented in engineering. One explanation for the dearth of Black and Latino men in engineering is that engineering (and STEM) identity often is not inclusive of People of Color. As a result, Black and Brown boys may be less likely to become interested in STEM subjects. The purpose of this study, then, was to investigate how the components of one afterschool engineering program tap into engineering identity formation among fourth- and fifth-grade Black and Brown boys. Leveraging research on the STEM and engineering identity, we argue that the program and its key components …

Socio-Ecological Analysis Of Artisanal Gold Mining In West Africa: A Case Study Of Ghana, Richard Takyi, Rasha Hassan, Badr El Mahrad, Richard Adade

Journal of Sustainable Mining

The surge in artisanal gold mining (AGM) activities and the associated environmental impact in Ghana have elicited several stakeholders' attempts to curb the problem. However, due to little understanding of the underlying issues, these efforts have been ineffective. This study aims to use a socio-ecological framework to analyze drivers of AGM activities, the environmental pressures, the state change, their impact on human welfare, and the management response as measures (DAPSI(W)R(M)) to the problem. Evaluate AGM's impact on Ghana's ability to achieve the United Nations Sustainable Development Goals (SDGs). Data were collected from relevant literature on the subject and analyzed with …

Discovery Of The Jussi Björling Copenhagen Tape, John H. Haley

Journal of the Jussi Björling Societies of the USA & UK

As Society members know by now, a new Society-sponsored CD is due out in the coming weeks that presents a recently discovered Jussi Björling live concert in Copenhagen on October 15, 1959, less than a year before Björling passed away from escalating heart trouble. I discovered this tape, which I own, and working together with Society members and expert audio restoration engineer Seth B. Winner, we put this project together, which is being released by JSP Records in London.

An Homage To Enrique Gilardoni (Celebrating His 80th Birthday), Bertil Bengtsson

Journal of the Jussi Björling Societies of the USA & UK

For many years I’ve had a firm belief that one sure sign of Jussi Björling’s greatness as a performing artist is the ability to join together people from all walks of life, irrespective of ethnicity, political affiliation, religion or country. Over the more than 30 years that I’ve studied, researched and lectured about Jussi I’ve had the great pleasure of making friends with fellow “Jussicologists”, both in Sweden and abroad. Many of them have become very close friends. One of the most highly treasured friendships is the one I’ve established with the foremost Jussicologist in South America, Enrique Gilardoni, whom …

The History Of An Autographed Photo, Enrique Gilardoni

Journal of the Jussi Björling Societies of the USA & UK

On that cold morning of February 23, Otniel Sobek woke with a strong idea in his mind. He had collected autographed photos of the main singers who appeared in the Vienna State Opera, but lacked the one of that young Swedish tenor that had already been presented there the year before singing Il trovatore, Aida and La bohème. Such was his success (despite he sang his roles in Swedish while the rest of the cast did it in German), that in 1937 he was again hired to sing nothing less than eight operas: La bohème, Il trovatore, Madama Butterfl y, …

Internet Of Things Software And Hardware Architectures And Their Impacts On Forensic Investigations: Current Approaches And Challenges, Abel Alex Boozer, Arun John, Tathagata Mukherjee

Journal of Digital Forensics, Security and Law

The never-before-seen proliferation of interconnected low-power computing devices, patently dubbed the Internet of Things (IoT), is revolutionizing how people, organizations, and malicious actors interact with one another and the Internet. Many of these devices collect data in different forms, be it audio, location data, or user commands. In civil or criminal nature investigations, the data collected can act as evidence for the prosecution or the defense. This data can also be used as a component of cybersecurity efforts. When data is extracted from these devices, investigators are expected to do so using proven methods. Still, unfortunately, given the heterogeneity in …

The Survey On Cross-Border Collection Of Digital Evidence By Representatives From Polish Prosecutors’ Offices And Judicial Authorities, Paweł Olber Dr

Journal of Digital Forensics, Security and Law

Dynamic development of IT technology poses new challenges related to the cross-border collection of electronic evidence from the cloud. Many times investigators need to secure data stored on foreign servers directly and then look for solutions on how to turn the data into a legitimate source of evidence. To study the situation and propose solutions, I conducted a survey among Polish representatives of public prosecutors' offices and courts. This paper presents information from digital evidence collection practices across multiple jurisdictions. I stated that representatives from the prosecution and the judiciary in Poland are aware of the issues associated with cross-border …

آليّات تعزيز المسؤوليّة الاجتماعيّة في مؤسّسات القطاع الخاص الفلسطيني, سمير مصطفى أبو مدللة استاذ مشارك, محمود حسين عيسى ماجستير

Journal of Al-Azhar University – Gaza (Humanities)

ملخص:

تكمن أهميّة الدّراسة في أنّها تتعرّض لمفهوم المسؤوليّة الاجتماعيّة، وهو مفهوم حديث البحث، فرضته فلسفة الإبداع الاجتماعي، وتطوّر الفكر الإداري والاقتصادي، وأصبح معياراً هامّاً من معايير نجاح مؤسّسات الأعمال.

هدفت الدّراسة إلى وضع تصوّر للآليّات والإجراءات الّتي من شأنها تعزيز وتفعيل المسؤوليّة الاجتماعيّة في مؤسّسات القطاع الخاص الفلسطيني.

تطرّقت الدّراسة إلى مفهوم المسؤوليّة الاجتماعيّة، وأبعادها، وأهميّتها، ونطاق ممارساتها، كما تناولت بالتحليل واقع المسؤوليّة الاجتماعيّة في مؤسّسات القطاع الخاص الفلسطيني، والتّحدّيات الّتي تواجه تلك المؤسّسات، ومن ثمّ استعراض الآليّات الكفيلة بتعزيز الممارسة الاجتماعيّة في مؤسّسات القطاع الخاص الفلسطيني.

استخدم الباحثان في التحليل المنهجين الوصفي والتّحليلي، لتوصيف مفاهيم الدّراسة، وتحليل العلاقة …

Justification Of The Main Parameters And Operating Modes Of The Crushers-Shredders Of Coarse Feed, K.D. Astanakulov, F.U. Karshiev, Sh.Kh. Gapparov

Irrigation and Melioration

The article presents the results of research on the justification of the parameters of the working bodies and operating modes of the mini crushers-shredders of coarse feed. On the basis of experimental research to study the effect of the rotor parameters Mini Crusher its qualitative performance indicators. According to the teachings found that rational parametres and operating modes-Crusher are: rotor length 350 mm; rotor diameter 550 mm; rotor speed 1290 min-1; the number of hammers 20 pcs; angle of rotation of the hammers 60.

Plan Dimensions Of The Flow Confinited By Cross Dams, On Rivers With Non-Symmetric Flooring, M.R. Bakiev, U.A. Kahhorov, A.А. Jakhonov

Irrigation and Melioration

Improving methods and technologies for calculating and designing floodplain transverse dams, taking into account the interaction of floodplain and riverbed flows to protect the banks from erosion and regulate riverbeds is one of the most important tasks. At the same time, the priority remains the transverse blind dams made of local soil with the attachment of their head. Their construction on rivers with two-sided asymmetric floodplains has its own characteristics, which consist in the need to take into account the morphology, the different roughness of the floodplain and the channel, the interaction of floodplain and channel flows, the asymmetry of …

Study Of Performance Of Vertical Drainage Well Construction From Polymer Materials, I.A. Akhmedov, Z.K. Mirkhasilova

Irrigation and Melioration

The article is devoted to the reconstruction and construction of vertical drainage wells. The use of vertical drainage wells is characterized by a decrease in the level of groundwater. The article presents data and typical regions of the use of vertical drainage wells.Also presented are mechanical, physical and chemical methods of well cleaning in practice. The information on the design and construction of vertical drainage wells is described. The analysis of corrosion resistance of vertical drainage well materials and their service life has been carried out. It is known that polymeric materials are resistant to corrosive environments. Using filters made …