Digital Commons Network^™

Adopting A Risk-Intelligent Approach To Digital Transformation: Four Traits Of Digitally Mature Organisations, Clarence Goh, Gary Pan, Poh Sun Seow, Yuanto Kusnadi, Seah Gek Choo, Cheryl Lim

Research Collection School Of Accountancy

Our objective is to understand how digitally mature organisations are managing the GRC aspects of their digital transformation programmes, and identify any traits or behaviours that could inform the development of best practices.

Tracking The Evolution Of Stare Decisis, Sam C. Ehrlich, Ryan M. Rodenberg

Management Faculty Publications and Presentations

At the United States Supreme Court, what is old is new again. In a series of recent opinions,1 the justices have repeatedly offered differing views on how stare decisis should be positioned when tasked with justifying or rejecting existing precedent. Indeed, in three recent Supreme Court decisions the justices have wrestled with the effect of stare decisis on future decisions. Reversing a decision, according to Justice Kagan, “demand[s] a ‘special justification.’” In contrast, Justice Thomas posited that “[w]hen faced with demonstrably erroneous precedent, my rule is simple: We should not follow it.” Chief Justice Roberts, in explaining his switch in …

Role Of Estrogen In Regulating Diet-Induced Obesity In Females, Ahmed Aladhami

Theses and Dissertations

Menopause puts a female at risk for several chronic diseases, including an increased risk of obesity. Estrogens are major sex hormones of females that dramatically decrease during menopause. Several murine studies have established the crucial role of estrogen and estrogen receptor alpha (ERα) on energy homeostasis, glucose metabolism, and insulin action. However, previous works have produced contradicting findings, hence, further work is needed to optimize better outcomes. Therefore, my dissertation focuses on optimizing and characterizing different estrogen-deficient models, as well as using novel double transgenic inducible and tissue-specific models that overexpress aromatase (estrogen producing enzyme) and estrogen receptor isomers alpha …

From The Surface To The Reactor: Identifying The Active Sites For Propane Dehydrogenation On Platinum-Based Catalysts Through Density Functional Theory, Experimental Data, And Uncertainty Quantification, Charles Henry Fricke

Theses and Dissertations

Propane dehydrogenation is a critical process of producing propylene, an important feedstock for the chemical industrial. There are multiple key processes to produce propylene in this manner, but one of the largest processes involves non-oxidative dehydrogenation on a platinum-tin alloy based catalyst. In general, these reactions and catalytic particles are complex, with many dehydrogenation, cracking, and reforming reactions taking place during these processes on multiple surfaces. With this in mind, ab initio computational catalysis models are used to generate further insight into these catalytic processes. In this dissertation, there are three aims to be solved: identifying the most likely active …

The Effect Of Low Dose Penicillin On Tumor Development In ApcMin/+ Mice, Kinsey Ann Sierra Meggett

Theses and Dissertations

Antibiotics have been our most effective weapon against bacterial infections since their discovery in the early 1900s. Their use has been critical in reducing mortality rate from infectious diseases. However, in the last few decades, the overuse of antibiotics, beginning at an early age and into adulthood, has become a growing concern globally. Penicillin is one of many extensively used antibiotics in early childhood that has been used to treat childhood infections. Recent studies showed that exposure to low dose penicillin can have adverse effects leading to chronic illness such as diabetes, allergies, inflammation, and susceptibility to obesity, with the …

Age-Dependent Increase In Tyrosine Level Depletes Tyrosyl-Trna Synthetase And Causes Neuronal Oxidative Dna Damage In Alzheimer’S Disease, Megha Jhanji

Theses and Dissertations

Alzheimer’s disease (AD) is the most common form of dementia, and it currently affects more than 50 million people worldwide. Much of the population develop late-onset AD after 65 and constitute more than 95% of the cases. Currently, there is no definitive cure or way to slow down the progression of this disease that addresses the neurodegeneration and loss of cognitive functions. Although the underlying cause of AD is still unknown, the “amyloid cascade hypothesis” attributed it to the aggregation of amyloid beta (AU+03B2) peptides and has been the focus for targeting most disease-modifying drugs in clinical trials. However, emerging …

Impact Of Acetylcholine On Internal Pathways To Basal Amygdala Pyramidal Neurons, Tyler Daniel Anderson-Sieg

Theses and Dissertations

The basolateral nuclear complex of the amygdala (BNC) – consisting of the lateral (LA), basolateral (BL), and basomedial nuclei (BM) – detects salient environmental stimuli (cue-detection) and motivates appropriate behavioral responses to their implied meaning (cue-guided behavior) via a precise pattern of internal circuitry. Glutamatergic signals representing environmental stimuli enter the LA and split into parallel streams that activate pyramidal neurons (PNs) in the anterior and posterior BL (BLa and BLp), which putatively mediate negative and positive emotions, respectively. The BL is the most densely innervated target of the cholinergic basal forebrain (CBF) and ACh transients (phasic ACh) in cortex …

Recent Advances In Catalytic Ethylene Epoxidation: Synthesis, Characterization, And Evaluation, Benjamin Thomas Egelske

Theses and Dissertations

First synthesized in 1859 by French chemist Charles-Adolphe Wurtz, ethylene oxide (EO) is produced from the direct epoxidation of ethylene and molecular oxygen over a low surface area α-Al₂O₃ supported silver (Ag) catalyst [1-6]. With a production capacity over 35 Mt/year, EO is the largest chemical by volume synthesized from a heterogeneously catalyzed process and is used in the production of ethylene glycol, ethoxylates, and ethanolamines [6, 7]. State-of-the-art catalyst formulations contain high loadings of Ag, typically 12-30wt%, required to recover activity in the presence of promoter elements which increase EO selectivity from ~75% for unsupported Ag to 80% for …

Operating Strategies And Disturbance Characterization For Dc Microgrids, Miles Leonard-Albert

Theses and Dissertations

The present state of the electrical grid is unable to meet the demands of transmission. Digital twin technology provides a promising solution to this problem by allowing for analysis and control of distributed energy resources. This thesis presents initial work towards development of a digital twin for a DC power system. Two versions of the DC power system are created and evaluated against randomly generated load profiles. System performance is evaluated on the basis of the quantity of the load that is unserviced by the generation and energy storage. Energy storage operating strategies that modify the model to prioritize different …

Impaired Metabolic Flexibility In A Mouse Model Of Leigh Syndrome, Richard Sterling Mccain Jr

Theses and Dissertations

Metabolic dysfunction burdens tissues with high energy demands, particularly the brain. Leigh syndrome is a mitochondrial encephalopathy stemming from genetic defects in the electron transport chain. Leigh syndrome patients develop lactic acidosis, ataxia, bilateral necrotizing lesions in the brainstem and basal ganglia, lesion microgliosis, and eventually death due to respiratory failure. The NADH dehydrogenase [ubiquinone] iron-sulfur protein 4 (NDUFS4) knockout mouse is an established model of Leigh syndrome due to impaired assembly of mitochondrial Complex I that develops motoric deficits and necrotizing lesions in the brainstem vestibular nuclei and olfactory bulb. In addition to the Complex I-derived bioenergetics defect, altered …

Structure And Stability Of Ag-Ir Bimetallic Catalysts Prepared By Electroless Deposition And Synthesis And Performance Of High Selectivity Movnbsbteox Mixed Oxides For Oxidative Dehydrogenation Of Ethane, Mozhdeh Parizad

Theses and Dissertations

Improvements in industrial thermal conversions can be realized through comprehensive catalytic studies, where enhanced catalyst stability and activity are desired. Catalyst performance can be greatly affected by structural changes at high temperatures. In the case of supported Ag-Ir particles, the surface free energy (SFE) can determine preferred arrangement of the component metals. The well-established methods of strong electrostatic adsorption (SEA) and electroless deposition (ED) have been used to synthesize highly-dispersed Ag/Ir on different alumina supports (δ,θ-Al2O3 and γ-Al2O3). Surface thermodynamics dictate that the Ir-Ag system should conform to minimize free energy resulting in a low SFE Ag layer localized on …

The Immune Modulatory Role Of Endocannabinoid Anandamide To Suppress Inflammation Through Regulation Of Microrna And Microbiome, Muthanna Ali Sultan

Theses and Dissertations

Cannabinoids are group of compounds that exerts their anti-inflammatory action through activation of CB1 and CB2 receptors and other minor receptors. In the current study, we investigated the effect of Anandamide (AEA) on Acute Respiratory Distress Syndrome (ARDS) induced by exposure to Staphylococcus Enterotoxin B (SEB) intranasally. We found that C57BL/6 mice treated with AEA showed improvement in the clinical functions of the lungs, accompanied by a decrease in the infiltration of inflammatory cells in the lung tissue, and a decrease in the secretion of pro-inflammatory cytokines. Furthermore, AEA regulated the miRNA profile of the mononuclear cells in the lungs …

Predicting Pavement Structural Condition Using Machine Learning Methods, Nazmus Sakib Ahmed

Theses and Dissertations

State departments of transportation recognize the need to incorporate pavement structural condition in their pavement performance models and/or decision processes used to select candidate projects for preservation, rehabilitation, or reconstruction at the network level. However, pavement structural condition data are costly to obtain. To this end, this paper develops and evaluates the effectiveness of two machine learning methods, Random Forest (RF) and eXtreme Gradient Boosting (XGBoost), for predicting a flexible pavement’s structural condition. The aim is to be able to predict whether a pavement section’s structural condition is poor or not based on Annual Average Daily Traffic (AADT), truck percentage, …

Identification Of Structural Signature Responses From Response Time Histories Using B-Spline Impulse Response Techniques, Shadhan Ahmed Al Kharusi

Theses and Dissertations

Structure Health Monitoring (SHM) is an essential practice for ensuring the safety of people and the structures itself. For this purpose, variety of global and local damage detection methods have been used to investigate damages. Global damage detection focus on identifying damage in early stages while local damage detection related to damage location, severity, and prediction of the remaining of the structure. Any damage in structure leads to a change to the properties and characteristics of the dynamic response.

Existing methods uses modal-based and response-based for damage detection. Both have several shortcoming associate with sensitivity of the damage and measurement …

The Role Of The School-Based Speech-Language Pathologist In The Identification, Assessment, And Remediation Of Dyslexia In Secondary Students, Lisa Marie Alves

Theses and Dissertations

The purpose of this mixed methods action research study was to increase the awareness and knowledge of secondary school professionals on dyslexia, including the role of the school-based speech-language pathologist. Two research questions guiding the quantitative data collection centered on the impact of a PowerPoint dyslexia training on the participants' knowledge and attitudes about dyslexia in the schools. In addition, two qualitative research questions guided the study involving the participants’ perceptions of the role of speech-language pathologists in a dyslexia protocol, and how to implement a dyslexia protocol in secondary-level schools. The results of the study indicate that the training …

Shedding Light On The Coupling Dynamics In Hybrid Nanostructures, Saba Arash

Theses and Dissertations

Here we present all-optical investigations of two hybrid nanostructures. In the first hybrid system, we study Janus-type nanofibers consisting of two hemi-cylinders of ferroelectric barium titanate and ferrimagnetic cobalt ferrite. Using the magnetic field-dependent polarization-resolved second harmonic generation technique, we observe a strong magnetoelectric coupling between the two ferroic constituents at room temperature. Corroborating these results by X-ray diffraction, we can also extract repeatable memory-dependent behaviors in these biphasic nanofibers. In the second hybrid system, we study the interaction between the semiconductor indium/gallium arsenide quantum dots and surface plasmon supporting silver structures in the weak coupling regime. When quantum dots …

Clemson Trustees Minutes, 2021 October 1, Clemson University Board Of Trustees

Minutes

No abstract provided.

Leveraging Digital Transformation To Build The Technology Of Tomorrow Using Yesterday’S Equipment, Evan Barnett

Theses and Dissertations

Today’s industry sectors are filled with machines developed years ago. Healthcare, manufacturing, sustainment operations, and many others have equipment that may be reliable, but lacks certain capabilities that the newest technology delivers. The digital environment is becoming a necessity for users who want greater insights into how to improve their processes. A solution to this problem would be to purchase the newest equipment that contains robust measures to generate, collect, and analyze data. However, this solution may not be financially feasible for some and for others may sacrifice machine downtime and reliability. To combat these issues, this research focuses on …

How Can Equity-Focused Inquiry Uncover The Causes For The Opportunity Gaps Our Students Of Color Experience?, Stephanie Becks

Theses and Dissertations

The purpose of this study was to determine how equity-focused inquiry could uncover gaps in opportunity for our students of color and determine root causes for those gaps. Through Inquiry as Stance and Critical Race Theory (CRT) as the driving frameworks, this study used practitioner inquiry to understand what gaps, if any, were present for students of color within our school. If gaps in opportunity were present, this study also aimed to discover what school level factors were contributing to the gaps. Three cycles of inquiry were used to help answer the following questions: (1) What common gaps in opportunity …

Implementing An Application Programming Interface For Promis Measures At Three Medical Centers, Michael Bass, Christian Oncken, Allison W. Mcintyre, Chris Dasilva, Joshua Spuhl, Nan E. Rothrock

2020-Current year OA Pubs

BACKGROUND: There is an increasing body of literature advocating for the collection of patient-reported outcomes (PROs) in clinical care. Unfortunately, there are many barriers to integrating PRO measures, particularly computer adaptive tests (CATs), within electronic health records (EHRs), thereby limiting access to advances in PRO measures in clinical care settings.

OBJECTIVE: To address this obstacle, we created and evaluated a software integration of an Application Programming Interface (API) service for administering and scoring Patient-Reported Outcomes Measurement Information System (PROMIS) measures with the EHR system.

METHODS: We created a RESTful API and evaluated the technical feasibility and impact on clinical workflow …

Friends And Foes: Extracellular Vesicles In Aging And Rejuvenation, Brian V Lananna, Shin-Ichiro Imai

2020-Current year OA Pubs

Extracellular vesicles (EVs) are released by many different cell types throughout the body and play a role in a diverse range of biological processes. EVs circulating in blood as well as in other body fluids undergo dramatic alterations over an organism's lifespan that are only beginning to be elucidated. The exact nature of these changes is an area of active and intense investigation, but lacks clear consensus due to the substantial heterogeneity in EV subpopulations and insufficiencies in current technologies. Nonetheless, emerging evidence suggests that EVs regulate systemic aging as well as the pathophysiology of age-related diseases. Here, we review …

Gendered Complications Of Covid-19: Towards A Feminist Recovery Plan, Naomi Cahn, Linda C. Mcclain

Faculty Scholarship

COVID-19 exposed the limitations in the current economic system on public and private support for gender equity and the intersecting impact of gender, race, and class in that lack of support. Women of color, particularly those who are Black, Latina, or Native American, were at the intersection of the inequities in the pandemic economy. The catalogue of COVID-19’s impact covers all aspects of women’s lives: work, family, education, health, reproduction, mental and physical well-being, and leisure. This Article argues that COVID-19 has complex implications for gender equality and gender equity as state and local governments, the federal government, and private …

Nudging Humans, Brett Frischmann

Faculty Publications

Behavioral data can and should inform the design of private and public choice architectures. Choice architects should steer people toward outcomes that make them better off (according to their own interests, not the choice architects’) but leave it to the people being nudged to choose for themselves. Libertarian paternalism can and should provide ethical constraints on choice architects. These are the foundational principles of nudging, the ascendant social engineering agenda pioneered by Nobel Prize winning economist Richard Thaler and Harvard law professor Cass Sunstein.

The foundation bears tremendous weight. Nudging permeates private and public institutions worldwide. It creeps into the …

Assessment Of Online Water-Soluble Brown Carbon Measuring Systems For Aircraft Sampling, Linghan Zeng, Amy P. Sullivan, Rebecca A. Washenfelder, Jack E. Dibb, Eric Scheuer, Teresa L. Campos, Joseph M. Katich, Ezra Levin, Michael A. Robinson, Rodney J. Weber

Faculty Publications

Brown carbon (BrC) consists of particulate organic species that preferentially absorb light at visible and ultraviolet wavelengths. Ambient studies show that as a component of aerosol particles, BrC affects photochemical reaction rates and regional to global climate. Some organic chromophores are especially toxic, linking BrC to adverse health effects. The lack of direct measurements of BrC has limited our understanding of its prevalence, sources, evolution, and impacts. We describe the first direct, online measurements of water-soluble BrC on research aircraft by three separate instruments. Each instrument measured light absorption over a broad wavelength range using a liquid waveguide capillary cell …

Teaching With Quantitative Data In The Social Sciences At The University Of New Hampshire: An Ithaka S+R Local Report, Patricia Condon, Eleta Exline, Louise Buckley

Faculty Publications

This exploratory study investigated the teaching practices of social science instructors at the University of New Hampshire who engage with undergraduate students using quantitative data in the classroom. The participants interviewed teach both general and discipline-specific data concepts as academic, work, and life skills. Primary challenges discussed by the participants that students face in engaging with these topics are understanding math and statistical concepts, learning new software and computing skills, limited prior exposure to data, and lack of retention of content from earlier courses. Participants addressed challenges in several ways in order to lower barriers to learning, including finding, vetting, …

High-Order Deterministic Sensitivity Analysis And Uncertainty Quantification: Review And New Developments, Dan Gabriel Cacuci

Faculty Publications

This work reviews the state-of-the-art methodologies for the deterministic sensitivity analysis of nonlinear systems and deterministic quantification of uncertainties induced in model responses by uncertainties in the model parameters. The need for computing high-order sensitivities is underscored by presenting an analytically solvable model of neutron scattering in a hydrogenous medium, for which all of the response’s relative sensitivities have the same absolute value of unity. It is shown that the wider the distribution of model parameters, the higher the order of sensitivities needed to achieve a desired level of accuracy in representing the response and in computing the response’s expectation, …

Why Are You Here? Modeling Illicit Massage Business Location Characteristics With Machine Learning, Anna White, Seth Guikema, Bridgette Carr

Articles

Illicit massage businesses are a venue for sex and labor trafficking in the United States. Though many of their locations are made publicly available through online advertising, little is known about why they choose to locate where they do. In this work, we use inferential modeling to better understand the spatial distribution of illicit massage businesses within the U.S. Based on addresses web-scraped weekly from online advertisements over 6 months, we modeled illicit massage business prevalence at the census tract and county levels. We used publicly available data to characterize census tracts and counties, finding that the state in which …

Infrastructure Risk Reduction: The Case Of Drinking Water Emergencies, Mark Paine

Dissertations

Public water systems are an integral part of community infrastructure. Drinking water contamination or service disruptions have the potential to cause economic losses, limit fire suppression capability, and result in human illnesses. Until 2016, the United States federal government had not issued a disaster declaration due to contaminated water. The first federal drinking water disaster declaration due to contaminated water serves as a sentinel event demonstrating the need to increase focus on public water systems during all phases of emergency management: mitigation, preparation, response, and recovery. Previous studies evaluating risks to vulnerable populations associated with drinking water primarily utilized qualitative …

The Extension Newsletter, Issue 107, Fall 2021, Wright State University Retirees Association

The Extension Newsletter

An eight page newsletter from the Wright State University's Retirees Association.

Temperature Characterization Of Unipolar-Doped Electroluminescence In Vertical Gan/Aln Heterostructures, Weidong Zhang, Tyler A. Growden, Paul R. Berger, David F. Storm, David J. Meyer, Elliott R. Brown

Physics Faculty Publications

An electroluminescence (EL) phenomenon in unipolar-doped GaN/AlN/GaN double-barrier heterostructures—without any p-type contacts—was investigated from 4.2 K to 300 K. In the range of 200–300 K, the extracted peak photon energies agree with the Monemar formula. In the range of 30 to 200 K, the photon energies are consistent with A-exciton emission. At 4.2 K, the exciton type likely transforms into B-exciton. These studies confirm that the EL emission comes from a cross-bandgap (or band-to-band) electron-hole radiative recombination and is excitonic. The excitons are formed by the holes generated through interband tunneling and the electrons injected into the GaN emitter region …