Digital Commons Network^™

Transcompartmental Sodium Imaging In Brain Cancer, Muhammad Khan

Yale Graduate School of Arts and Sciences Dissertations

According to the World Health Organization (WHO), cancers are the second-leading cause of death in the United States, next to cardiovascular disease. Although treatments of some solid tumors with high mortality are showing promise, there is one exception: glioblastoma multiforme (GBM). Even with advanced therapies, median survival rate for GBM patients is dismal because most are not diagnosed early enough. A hallmark of normal physiology is maintenance of large ion gradients across the cell membrane, mainly for sodium (Na + ) and potassium (K + ) ions. Under normal conditions, high and low Na + in extracellular (Na + ) …

Practicality Of Quantum Random Access Memory, Connor Hann

Yale Graduate School of Arts and Sciences Dissertations

Quantum computers are expected to revolutionize the world of computing, but major challenges remain to be addressed before this potential can be realized. One such challenge is the so-called data-input bottleneck: Even though quantum computers can quickly solve certain problems by rapidly analyzing large data sets, it can be difficult to load this data into a quantum computer in the first place. In order to quickly load large data sets into quantum states, a highly-specialized device called a Quantum Random Access Memory (QRAM) is required. Building a large-scale QRAM is a daunting engineering challenge, however, and concerns about QRAM’s practicality …

The Rheology Of Striated Muscles, Khoi Dac Nguyen

Yale Graduate School of Arts and Sciences Dissertations

Striated muscles are actuators of animal bodies. They are responsible for several biomechanical functions critical to survival and these include powering the cardiovascular system and modulating the mechanical interactions the body has with its surroundings. Nearly two centuries of active research on muscle phenomena has led to detailed insights into its microscopic composition, but accurate predictive models of muscle at larger scales remain elusive. This thesis reports on efforts to accurately capture the mechanical properties of striated muscles based on current knowledge of actomyosin dynamics. Specifically, this thesis derives the rheology of striated muscles from the dynamics. Muscle rheology is …

Pairwise Hydrodynamic Interactions Of Permeable Particles And Flow-Induced Structuring In Dilute Suspensions, Rodrigo Bento Reboucas

Yale Graduate School of Arts and Sciences Dissertations

The study of particle-level interactions in suspension flows enables a better understanding and control of systems where suspensions play a key role. Examples include the physiology of blood flow microcirculation, flow-induced segregation of polydisperse suspensions, particle aggregation in marine environments, and filtration processes, to name a few. In these systems, a detailed description of the hydrodynamic interactions between the particles and between the particles and fluid boundaries characterize the evolution of the suspension microstructure. Typically, the characteristic size of the particles is small compared to the imposed flow length scale, and hence low-Reynolds-number conditions usually apply. In the dilute regime, …

A Hybrid Sdn-Based Architecture For Wireless Networks, Qiaofeng Qin

Yale Graduate School of Arts and Sciences Dissertations

With new possibilities brought by the Internet of Things (IoT) and edge computing, the traffic demand of wireless networks increases dramatically. A more sophisticated network management framework is required to handle the flow routing and resource allocation for different users and services. By separating the network control and data planes, Software-defined Networking (SDN) brings flexible and programmable network control, which is considered as an appropriate solution in this scenario.Although SDN has been applied in traditional networks such as data centers with great successes, several unique challenges exist in the wireless environment. Compared with wired networks, wireless links have limited capacity. …

Social Control And Incarceration In Lesotho: A History Of Strategies, 1850-1970, Samuel John Severson

Yale Graduate School of Arts and Sciences Dissertations

This dissertation explores how technologies and infrastructures for promoting control and cohesion have interfaced with the social and political history of Lesotho over the longue durée. This approach allows for tracing lines of historical continuity and change during a period spanning the coalescing of the nation from communities on the Southern African Highveld in the early-19th century, the onset and grinding realities of British colonial rule and the rise of a local economy dependent on labor migration to South Africa, and the unravelling of empire and the challenges of governance in the years following official national liberation in 1966. I …

Proteome-Wide Screening For Mitogen-Activated Protein Kinase Docking Motifs And Interactors, Guangda Shi

Yale Graduate School of Arts and Sciences Dissertations

AbstractProteome-wide screening for mitogen-activated protein kinase docking motifs and interactors Guangda Shi 2021 Kinases catalyze the transfer of phosphate to substrates, a reaction critical for many cellular events. Mitogen-activated protein kinases (MAPKs), including ERK, p38, and JNK, phosphorylate hundreds of substrates, and each plays a pivotal role in distinct processes such as cell growth, survival, differentiation, and apoptosis. To correctly respond to external stimuli, MAPKs use several mechanisms to achieve a high degree of selectivity for their target substrates. A critical aspect of MAPK specificity comes from docking interactions occurring between sites distal from the site of catalysis and short …

On The Role Of Stability In Animal Morphology And Neural Control, Neelima Sharma

Yale Graduate School of Arts and Sciences Dissertations

Mechanical stability is vital for the fitness and survival of animals and is a crucial aspect of robot design and control. Stability depends on multiple factors, including the body's intrinsic mechanical response and feedback control. But feedback control is more fragile than the body's innate mechanical response or open-loop control strategies because of sensory noise and time-delays in feedback. This thesis examines the overarching hypothesis that stability demands have played a crucial role in how animal form and function arise through natural selection and motor learning. In two examples, finger contact and overall body stability, we investigated the relationship between …

Development Of Diverse Bifunctional Molecules For Interrogating Dcps, Her3, Brachyury, And Phosphorylation-Driven Diseases Towards Therapeutic Applications, Jake Charles Swartzel

Yale Graduate School of Arts and Sciences Dissertations

Technologies that hijack cellular pathways using bifunctional small molecules have recently risen to the forefront of the drug discovery world. The first targeted protein degradation (TPD) technology to be developed, PROteolysis Targeting Chimeras (PROTACs), were disclosed two decades ago. The recent successes of AR and ER-degrading PROTACs in pioneering clinical trials has propelled interest in developing novel platforms to further expand the druggable proteome and the arsenal of strategies that are available for therapeutic intervention. This thesis is focused on the development of novel bifunctional molecules that enable interrogation of diseases driven by traditionally challenging protein targets. The first chapter …

Three Essays In Environmental And Transportation Economics, Stephanie Margalit Weber

Yale Graduate School of Arts and Sciences Dissertations

The transportation sector contributes around 30% of US greenhouse gas emissions, and reducing these emissions is an important part of any large-scale climate policy. This dissertation examines three questions about policies and programs designed to reduce emissions from heavy-duty trucks and cars, using a range of economic data and methodologies.The first chapter considers the recent federal fuel efficiency standards for heavy-duty trucks, which mandated that the average fuel efficiency of trucks sold by each manufacturer reach certain levels. To estimate the welfare implications of the policy, I develop a model of supply and demand in the sector using detailed data …

Electrochemical Hydrogen Peroxide Generation With Anthraquinone Chemistry For Advanced Oxidation Process, Qianhong Zhu

Yale Graduate School of Arts and Sciences Dissertations

Hydrogen peroxide plays a critical role in many industrial applications, including chemical synthesis and environmental remediation. For example, in advanced oxidation process of water treatment, hydrogen peroxide is activated to hydroxyl radical by catalysts or UV light for non-selective and rapid degradation of non-biodegradable, toxic, recalcitrant organic micropollutants. Industrial anthraquinone process, which synthesizes hydrogen peroxide from hydrogen and oxygen gas in organic phase, requires intensive capital investment, expensive reactants, high energy inputs, and raises many environmental concerns. Electrochemical production of hydrogen peroxide with air, water and electricity as inputs has emerged as a promising alternative method because it is low-cost, …

The Path To Extreme Precision Radial Velocity With Expres, Lily Ling Zhao

Yale Graduate School of Arts and Sciences Dissertations

The field of exoplanets is currently poised to benefit hugely from improved radial velocity (RV) precision. Extreme precision radial-velocity (EPRV) measurements, capable of detecting planetary signals on the order of 10-30 cm/s, will deliver integral planetary parameters, be sensitive to a missing category of lower-mass planets, grant a deeper understanding of multi-planet architectures, and support both current and future space missions such as TESS and JWST. The ability of EPRV to deliver mass estimates is essential for comprehensively characterizing planets, understanding formation histories, and interpreting atmospheric spectra. Until recently, RV precision had stalled at around 1 m/s, i.e. signals with …

Fitting Women To Their Work: The Vocational Vision Of Helen M. Bennett, Lisa R. Lindell

Hilton M. Briggs Library Faculty Publications

"A WOMAN CAN DO ANYTHING IF SHE PUTS HER MIND ON IT."' This conviction propelled the career choices of Helen Marie Bennett in the late nineteenth and early twentieth centuries and the vocational message she communicated. Bennett commenced her wide-ranging life's pursuits in western South Dakota, where she was raised, and brought them to culmination in Chicago, where she became a leader in the emerging field of vocational guidance. She firmly believed that all paths should be open to women and that women had a responsibility to find and follow their own vocation. Bennett's life experiences and interests sparked and …

Better Medicine, Lehigh Valley Health Network

Better Medicine

No abstract provided.

Ai: Friend Or Foe? (And What Business Leaders Need To Know), Singapore Management University

Perspectives@SMU

Artificial intelligence presents significant opportunities for business – as well as not insignificant threats to humanity – and governance frameworks are urgently needed to create a fair and equitable future under AI

Strategies To Build An Impactful Institutional Repository: A Case Study Of Singapore Management University, Pin Pin Yeo

Research Collection Library

An institutional repository (IR) was launched in 2010 for a young university in Singapore. The motivations of setting up an IR were to dissemination the research output through open access, to promote the university and researchers, and to help increase their research impact. A review was conducted on the strategies to build the IR. Some quantitative and qualitative performance indicators were selected and used to measure the success of the IR. The findings of the review were presented and strategies that were successful in building the IR were having a workflow process between the research information system and the repository, …

How Information Centres Have Been Key Players In The Development Of Our Business Schools​, Rajendra Munoo

Research Collection Library

No abstract provided.

Honors Oracle, October 2021, Marshall University Honors College

Honors Oracle

Marshall University’s Honors College newsletter.

Marshall Magazine Autumn 2021, Marshall University

Marshall Magazine

No abstract provided.

Engineering At San Jose State University, Fall 2021, San Jose State University, Charles W. Davidson College Of Engineering

Engineering at San Jose State University

No abstract provided.

Santa Clara Magazine, Volume 62 Number 2, Fall 2021, Santa Clara University

Santa Clara Magazine

18 - WE ARE THE CHAMPIONS The pandemic stole an entire year of games from them. But this team still won it all. Written by Harold Gutmann. Illustrated by Liam Eisenberg.

26 - INFORMED BY STRUGGLE. How hardship forged a sense of gratitude in SCU finance professor Meir Statman and his wife, Navah. Written by Deborah Lohse.

30 - TWEETING GOOD There’s a Bronco who finds hope, God, and cat pictures online. We talk with @padreSJ. Interviewed by Leslie Griffy. Illustrated by Kyle Hilton.

34 - SIGNALS FROM A CHANGING PLANET. The imprints of humans on the environment spell a …

Civichon 1.0: City In A Village, Catalogue For Civichon Exhibition In Vienna Biennale 2021, Albert L. Park, Kyong Park, Annie Pedret

EnviroLab Asia

No abstract provided.

Profile: A Model For Living And Learning, Communications And Marketing

Profile (1996-)

In this issue: Campaign Results; Janet Schrunk Ericksen Named Acting Chancellor; UMN Morris Legacy Spans Four Generations; Giving News; Campus News Briefs; The Big Picture; Alumni News; Class Notes; Cougar News

2021–2022 Bulletin Of Information, Notre Dame Law School

Bulletins of Information

CONTENTS

• Admissions Information
• Academic Calendar
• Tuition and Fees
• Academic Requirements
• Off-Campus Programs
• Senior Administrative Leadership
• Hoynes Code

Incident Light And Morphology Determine Coral Productivity Along A Shallow To Mesophotic Depth Gradient, Michael P. Lesser, Marc Slattery, Curtis D. Mobley

Faculty and Student Publications

While the effects of irradiance on coral productivity are well known, corals along a shallow to mesophotic depth gradient (10–100 m) experience incident irradiances determined by the optical properties of the water column, coral morphology, and reef topography. Modeling of productivity (i.e., carbon fixation) using empirical data shows that hemispherical colonies photosynthetically fix significantly greater amounts of carbon across all depths, and throughout the day, compared with plating and branching morphologies. In addition, topography (i.e., substrate angle) further influences the rate of productivity of corals but does not change the hierarchy of coral morphologies relative to productivity. The differences in …

Carbon Forward: Advanced Markets For Value-Added Products From Coal, Rodney Andrews

National Coal Council Reports

No abstract provided.

The 4th Annual Undergraduate Fall Symposium Category Winners, West Virginia University

Fall Undergraduate Research Symposium

No abstract provided.

4th Annual Fall Undergraduate Research Symposium, West Virginia University

Fall Undergraduate Research Symposium

No abstract provided.

Taylor: A Magazine For Taylor University Alumni, Parents And Friends (Fall 2021), Taylor University

The Taylor Magazine (1963-Present)

The Fall 2021 edition of Taylor Magazine, published by Taylor University in Upland, Indiana.

Faith-Based Social Entrepreneurial Orientation: A Case Study Of Evangelicals, Richard Clark

Business as Mission Theses and Dissertations

The focus of this study is the experiences of eight individual evangelical social entrepreneurs within their congregations. What type of legitimacy do they seek and/or receive for? Do they sense any pressure to conform/motivations to act relative to their congregation’s values/identity? Do these relationships encourage or discourage their entrepreneurial orientation/intensity and in what ways?

The primary research question is “how does embeddedness in an evangelical faith community affect the experiences and expression of social entrepreneurial orientation and intensity for evangelical faith-based social entrepreneurs, if at all?”

The study identifies three types of congregations in terms of their relationship to the …