Digital Commons Network^™

Biophysical Evaluation Of Rhesus Macaque Fc Gamma Receptors Reveals Similar Igg Fc Glycoform Preferences To Human Receptors, Andrew R. Crowley, Nana Yaw Osei-Owusu, Gillian Dekkers, Wenda Gao, Manfred Wuhrer, Diogo M. Magnani, Keith A. Reimann, Seth H. Pincus, Gestur Vidarsson, Margaret E. Ackerman

School of Medicine Faculty Publications

Rhesus macaques are a common non-human primate model used in the evaluation of human monoclonal antibodies, molecules whose effector functions depend on a conserved N-linked glycan in the Fc region. This carbohydrate is a target of glycoengineering efforts aimed at altering antibody effector function by modulating the affinity of Fcγ receptors. For example, a reduction in the overall core fucose content is one such strategy that can increase antibody-mediated cellular cytotoxicity by increasing Fc-FcγRIIIa affinity. While the position of the Fc glycan is conserved in macaques, differences in the frequency of glycoforms and the use of an alternate monosaccharide in …

Assessing The Success Of The 2020 Kansas State Research And Extension Summer Research Program: A Virtual Research Experience, Lonnie Hobbs, Jr., Zelia Z. Wiley, Raymond Thomas

Professional Agricultural Workers Journal

Ethnic minorities, and specifically African American students are not participating in graduate programs at the same rate as non-minority students. In 2006, Kansas State University College of Agriculture Diversity Programs Office (DPO) established the Kansas State Research and Extension (KSRE) Summer Research Fellows Program to expose African American and other ethnic minority students to the agricultural sciences graduate research opportunities. Due to the Covid-19 pandemic, the 2020 KSRE Summer Research Fellows Program was held virtually to protect the health and safety of participants. The purpose of this study was to evaluate the effectiveness of the virtual program. Data from five …

Expression, Purification And Refolding Of A Human Na V 1.7 Voltage Sensing Domain With Native-Like Toxin Binding Properties, Ryan V. Schroder, Leah S. Cohen, Ping Wang, Joekeem D. Arizala, Sébastien F. Poget

Publications and Research

The voltage-gated sodium channel NaV1.7 is an important target for drug development due to its role in pain perception. Recombinant expression of full-length channels and their use for biophysical characterization of interactions with potential drug candidates is challenging due to the protein size and complexity. To overcome this issue, we developed a protocol for the recombinant expression in E. coli and refolding into lipids of the isolated voltage sensing domain (VSD) of repeat II of NaV1.7, obtaining yields of about 2 mg of refolded VSD from 1 L bacterial cell culture. This VSD is known to be involved in the …

Ucc Minutes, October 12, 2021, University Curriculum Council

UCC Agendas/Minutes

No abstract provided.

Interview With Greg Kieffer, Greg Kieffer, Aaron Cervantez, Leslie Torres, Stephanie Medellin

Community Historical Archaeology Project with Schools (CHAPS) Oral Histories

No abstract provided.

Advancing Behavioral Health Literacy, James Scollione

Journal of Social, Behavioral, and Health Sciences

Accessing, comprehending, and using information to make informed decisions and improve one’s overall health or well-being are the foci of health literacy. The concept of behavioral health was introduced in the early 1980s and, since then, it has influenced new ideas (e.g., behavioral health literacy and integrated behavioral health care) and gained research and public attention. My aim is to provide an overview of definitions (i.e., health literacy, mental health literacy, and behavioral health literacy) and their connection to each other. I propose an expanded and honed definition of behavioral health literacy to enhance the behavioral health literacy and well-being …

Niche Applications And Flexible Devices For Wave Energy Conversion: A Review, Emiliano Renzi, Simone Michele, Siming Zheng, Siya Jin, Deborah Greaves

School of Engineering, Computing and Mathematics

We review wave energy conversion technologies for niche applications, i.e., kilowatt-scale systems that allow for more agile design, faster deployment and easier operation than utility scale systems. The wave energy converters for niche markets analysed in this paper are classified into breakwater-integrated, hybrid, devices for special applications. We show that niche markets are emerging as a very vibrant landscape, with several such technologies having now achieved operational stage, and others undergoing full-scale sea trials. This review also includes flexible devices, which started as niche applications in the 1980s and are now close to commercial maturity. We discuss the strong potential …

Criteria And Standards For Healthcare Buildings Design Through Sustainability Criteria., Ahmed El Deep, Sherif Sheta, Wael Moustafa

Mansoura Engineering Journal

Increased interest in providing health care services at all levels through the understanding of modern societies of the importance of good health of the individual and society health is as defined by the World Health Organization "WHO" World Health Organization is a state integration between the three elements physical, psychological and social" , In the past, the idea of health care facilities and hospitals rely on something to offer the services of the hos[ital., but the modern from New Paradigms. It is based on the requirements of the patient and confort. We find in the new model for building health …

Urban Areas Development Through The Process Of Environmental Impact Assessment., Riyadh Alshamiri

Mansoura Engineering Journal

The research aims to describe and analyze the environmental impact Assessment of urban areas, and to identify deficiencies that emerges from the environmental impact Assessment process, and access to the expected solutions of Environmental Impact Assessment System in the urban areas development. To achieve the aim of research and through the analytical method, the search begins by giving a theoretical background for environmental impact Assessment and the urban areas development. Then identify the gaps of environmental impact Assessment process in the urban area development and expected solutions from this process. Eventually, the paper provides a number of findings and recommendations …

Characteristics Of Plan Poiseuille Flows Under The Effect Of Electro-Magnetics Fields., A. El-Zahaby, M. Bassiouny, A. Khalil, E. El-Shenawy, E. El-Agouz, M. Amro

Mansoura Engineering Journal

The fully developed flow between two parallel plates in an electrically conducting fluid under the acting of electromagnetic fields is solved analytically. The value of flow rate. Velocity. Share stress and skin friction coefficient at the plates are derived. It is noticed that the electromagnetic forces are able to derive the flow in the absence of the pressure gradient also; the flow characteristics are largely changed when the electromagnetic fields are applied in the presence of the pressure gradient. The change in velocity. Shear stress and skin friction coefficient are represented as a function of the geometrical ratio between the …

Who Do College Students Turn To For Financial Aid And Student Loan Advice, And Is It Advice Worth Following?, Casandra E. Harper, Lisa Scheese, Enyu Zhou, Rajeev Darolia

Journal of Student Financial Aid

In this article, we examine the sources of information that college students turn to as they make decisions related to financial aid and student loans. Based on interview data from 25 undergraduate students from one public, four-year institution, our results reveal a great amount of variation in the number and nature of sources on which students rely. Across nearly all cases, students believed their access to assistance to be insufficient. This was true even for students with parents who attended college—commonly considered to be a high-quality source of support for students, when available—as students often found their advice outdated, confusing, …

Hidden Inequality: Financial Aid Information Available To College Students With Disabilities Attending Public Four-Year Institutions, Emily L. Perlow, Ryan S. Wells, Mujtaba Hedayet, Jenny Xia, Heather Maclean, Emily Ding, Angela Mccall

Journal of Student Financial Aid

College students with disabilities often encounter systems and processes that do not serve them well. Financial aid, structured in ways that can be particularly burdensome to students with disabilities, is one such system. This study used web-based content analysis of the largest public four-year institution in each state to explore how institutions explain and provide information and resources related to financial aid and whether they are equitable, consistent, and useful for students with disabilities specifically. The findings suggest that available information most often does not assist students in understanding how their disability-related needs can be supported or hindered by financial …

The Impact Of Light Spectrum And Intensity On The Growth, Physiology, And Antioxidant Activity Of Lettuce (Lactuca Sativa L.), Shiren J. Mohamed, Hail Z. Rihan, Naofel Aljafer, Michael P. Fuller

School of Biological and Marine Sciences

This study focused on the physiology, growth and antioxidant activity response of hydroponically grown lettuce (Lactuca sativa L.) under sole-source LED lighting of differing spectra. Lighting spectra were provided by differing combinations of LEDs of three different peak wavelengths, (Blue 435, Blue 450, and Red 663 nm) with ratios of B450/R663: 1.25 ± 0.1, B450/R663: 1.25 ± 0.1, and B450/R663 1:1 at two light intensities of photosynthetically active radiation (PAR) (270 μmol m−2 s−1 and 60 μmol m−2 s−1). A further experiment was conducted, in which Blue and Red LEDs were supplemented with Green (Blue 450, Red 663, and Green …

Collagen-Based Biomaterials With Possible Therapeutic Effects, Ramona Mihaela Nedelcuţă, Gigi Călin, Mihai Cristian Nedelcuţă, Vlad Dumitru Baleanu, Dragos Virgil Davitoiu, Bogdan Socea, Bogdan-Petre Stănoiu

Journal of Mind and Medical Sciences

Epidermolysis bullosa (EB) is a rare, serious genetic disease, incurable through the current means. Apart from this initial definition, there was later some ease in the definition of the disease, including the manifestations of toxic epidermal necrolysis and Stevens Johnson syndrome in this entity. In medical practice, there are cases that do not overlap with the description in the literature, thus the treatment must be adapted and personalized to the particularities. We present the case of a female new-born, with "de novo" mutation for the early-onset antenatal epidermolysis and our personalized therapeutic management, based on collagen from bovine corneas by …

Therapeutic Efficacy Of Mesenchymal Stem Cells For Cardiovascular Diseases, Dragana Radoje Miloradovic, Dragica Radoje Pavlovic, Miodrag Bozidar Stojkovic, Sanja Bratislav Bojic, Vladislav Bogdan Volarevic, Marina Milosav Gazdic Jankovic, Biljana Tomislav Ljujic

Journal of Mind and Medical Sciences

Despite the improvements in pharmacological and surgical treatments, cardiovascular diseases (CVDs) are the number one cause of death worldwide. During the last two decades, the search for new therapies has been revolutionized with the growing knowledge of stem cell biology. Due to their huge differentiation capacity and paracrine effects, mesenchymal stem cells (MSCs) are a promising tool for the treatment of CVDs. The encouraging outcomes of preclinical studies using MSCs as a treatment for diseased myocardium have set the scene for worldwide clinical trials. In this review, we overview either complete or ongoing clinical trials using MSCs for the therapy …

Ai, Ml, And Algorithms, Oh My: How Technology Affects Search Results, Marydee Ojala

Midwest Business Librarian Summit (MBLS)

AI, ML, and Algorithms, Oh My: How Technology Affects Search Results

There’s no doubt that artificial/augmented intelligence, machine learning, and algorithms affect your search results. Most business researchers understand that their web searches are influenced by the underlying technologies and that the algorithms in play are numerous and not disclosed by search engine companies. However, AI is also used by our library subscription databases—you know, the ones we pay money for. Learn the five basic things you should know about the effect of these technologies on your search results.

Jim Murry Memorial Memory Book, Evan Barrett

Supplementary Materials

Booklet remembering the legacy of Jim Murry.

Ada News - 10/11/2021, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

The Echo: October 11, 2021, Taylor University

2021-2022 (Volume 109)

Taylor names new provost, VP of marketing — Mask mandate lifts while vaccine rate sits at 35% — Upland grant to grow downtown — New intercultural resources available online — Dairy Queen coming to Gas City — Unified Robotics Championship to be held at Taylor — A sneak peek into Walnut Creek Market — Josiah Friesen shares his music composition process — We love the DC staff — Support your peers at shop the loop — This may be the best advice you’ve been given — Smith pursues music career while being a full-time student — Art departments previews showcases …

Human 5’-Tailed Mirtrons Are Processed By Rnasep, Mohammad Farid Zia

Dissertations

Approximately a thousand microRNAs (miRNAs) are documented from human cells. A third appear to transit non-canonical pathways that typically bypass processing by Drosha, the dedicated nuclear miRNA producing enzyme. The largest class of non-canonical miRNAs are mirtrons which eschew Drosha to mature through spliceosome activity. While mirtrons are found in several configurations, the vast majority of human mirtron species are 5’-tailed. For these mirtrons, a 3’ splice site defines the 3’ end of their hairpin precursor while a “tail” of variable length separates the 5’ base of the hairpin from the nearest splice site. How this tail is removed is …

Executive Committee Resolution Sr 21-22-01, Marshall University Faculty Senate

Resolutions

No abstract provided.

Multi-Organs-On-Chips For Testing Small-Molecule Drugs: Challenges And Perspectives., Berivan Cecen, Christina Karavasili, Mubashir Nazir, Anant Bhusal, Elvan Dogan, Fatemeh Shahriyari, Sedef Tamburaci, Melda Buyukoz, Leyla Didem Kozaci, Amir K Miri

Henry M. Rowan College of Engineering Departmental Research

Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug-body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance …

What Kind Of Information Does The Era Of Climate Change Require?, Jo Guldi

History Faculty Publications

This article explores the promise of institutions and infrastructures associated with democ- racy to limit the worst consequences of climate change. The article highlights the appar- ent conflict between expert governance on the one hand, and, on the other hand, calls for democratization that reflect the diverse perspectives of groups whose rights and labor have been exploited over historical timescales. Drawing on the history of bureaucracy and governance, this article argues that the apparent contradiction between the two poles of discourse can be reconciled by a system of information infrastructure designed to cre- ate a robust, accountable system of environmental …

Uncovering Disease Mechanisms In A Novel Mouse Model Expressing Humanized Apoeε4 And Trem2*R47h., Kevin P Kotredes, Adrian Oblak, Ravi S Pandey, Peter Bor-Chian Lin, Dylan Garceau, Harriet M. Jackson, Asli Uyar, Rita O'Rourke, Sarah O'Rourke, Cynthia Ingraham, Daria Bednarycek, Melisa Belanger, Zackary Cope, Kate E Foley, Benjamin A Logsdon, Lara M Mangravite, Stacey J Sukoff Rizzo, Paul R Territo, Gregory W. Carter, Michael Sasner, Bruce T Lamb, Gareth R Howell

Faculty Research 2021

Late-onset Alzheimer's disease (AD; LOAD) is the most common human neurodegenerative disease, however, the availability and efficacy of disease-modifying interventions is severely lacking. Despite exceptional efforts to understand disease progression via legacy amyloidogenic transgene mouse models, focus on disease translation with innovative mouse strains that better model the complexity of human AD is required to accelerate the development of future treatment modalities. LOAD within the human population is a polygenic and environmentally influenced disease with many risk factors acting in concert to produce disease processes parallel to those often muted by the early and aggressive aggregate formation in popular mouse …

2021-October-11-Calling The Games, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY –  (October 11, 2021) They predict match-ups, hype up the crowd, and call the game as they see it.

They share information about player stats and also help newcomers – and veteran audience members too – understand what is happening during the game, as well as behind the scenes (…or screens).

And the four students at East Tennessee State University who are casters for esports during the upcoming year will tell you they also get to have an amazing amount of fun.

Introducing Levi Everroad, Spencer Jedrzejek, Chris Moser and Colleen Sharkey.  They are all students at ETSU …

Addressing The Learning Loss During The Covid-19 Pandemic Through The Adaptation Of Virtual Platforms, Nazrul I. Khandaker, Anika Nawar Mayeesha, Violeta Escandon Correa, Toralv Munro, Andrew Singh, Matthew Khargie, Ality Aghedo, Jasmin Budhan, Krishna Mahabir, Belal A. Sayeed

Publications and Research

The York College-hosted NASA MAA (MUREP AEROSPACE ACADEMY) has always played a pivotal role in minimizing the learning loss during the summer months, which was heightened during the pandemic. Support from AT&T, Con Edison and NASA enabled the MAA program at York College to offer a virtual STEM education with an earth science concentration to 1000 plus underserved K1-12 students from the community last summer, including 160 high school students. Two factors made this endeavor fruitful: allowing additional time to engage in STEM lessons and increasing self-motivation to successfully accomplish assigned tasks. Students built partnerships and resolved technical issues with …

An Extensive Virtual Outreach Approach By Spe Dhaka University Chapter For Geoscience Education Amidst The Covid-19 Pandemic, Noshin Sharmili, Anika Nawar Mayeesha, Syed Humayun Akhter, Nazrul I. Khandaker

Publications and Research

The Society of Petroleum Engineers (SPE) Dhaka University (DU) Chapter in Bangladesh commenced its journey on 1st October 2007. From the beginning, it has always been students-centered and fixated to pique broader geoscience disciplined-based interests of the members and arrange several annual seminars, conferences, lecture programs, workshops, and general meetings. Many of these webinars were led by distinguished geoscience professionals known domestically and globally. Engaging and inspiring students, particularly females, in practical and innovative thinking concerning the present energy crisis and exploring the world’s energy sectors remain the central theme in its offerings. The SPE DU Chapter organized a wide …

Determination Of Sustainable Zones For Groundwater Abstraction From The Multi-Layered Aquifer System In The Bengal Basin, Bangladesh, Anwar Zahid, Muhammad Qumrul Hassan, Nazrul I. Khandaker

Publications and Research

The use of deep groundwater (±300 m deep) is becoming an important issue in the Bengal Basin, due to both water quality problems and an acute shortage of available water in upper aquifers. In southeastern Bangladesh, multi-layered aquifer conditions exist with arsenic contamination at shallow depths, and high iron and brackish groundwater occurring mainly in the deeper layers. Many previous studies have offered explanations for the high concentrations of dissolved arsenic in groundwater - most of which proposed that the arsenic is derived from geo-genic sources and its release in groundwater is through natural processes, not the result of anthropogenic …

The Importance Of Monitoring To Assess The Impact Of Climate Change On Groundwater Resources In Bangladesh, Muhammad Qumrul Hassan, Anwar Zahid, Nazrul I. Khandaker

Publications and Research

Groundwater is the major source of fresh water across much of the world, but there has been very little study on the impacts of climate change on this precious and finite resource. Rising levels of greenhouse gases are likely to increase the global average surface temperature over the next 100 years, raise sea levels and reduce soil moisture. The amount of water stored in the soil is fundamentally important to agriculture and influences the rate of actual evaporation, groundwater recharge and runoff. Rising sea levels would cause the tidal saltwater wedge to intrude further upstream in rivers, with resulting changes …

Particulate Oxalate-To-Sulfate Ratio As An Aqueous Processing Marker: Similarity Across Field Campaigns And Limitations, Miguel Ricardo A. Hilario, Ewan Crosbie, Paola Angela Bañaga, Grace Betito, Rachel A. Braun, Maria Obiminda L. Cambaliza, Andrea F. Corral, Melliza Templonuevo Cruz, Jackie E. Dibb, Genevieve Rose Lorenzo, Alexander B. Macdonald, Claire E. Robinson, Michael Shook, James Bernard Simpas, Connor Stahl, Edward Winstead, Luke Ziemba, Armin Sorooshian

Physics Faculty Publications

Leveraging aerosol data from multiple airborne and surface-based field campaigns encompassing diverse environmental conditions, we calculate statistics of the oxalate-sulfate mass ratio (median: 0.0217; 95% confidence interval: 0.0154 – 0.0296; R = 0.76; N = 2948). Ground-based measurements of the oxalate-sulfate ratio fall within our 95% confidence interval, suggesting the range is robust within the mixed layer for the submicrometer particle size range. We demonstrate that dust and biomass burning emissions can separately bias this ratio towards higher values by at least one order of magnitude. In the absence of these confounding factors, the 95% confidence interval of the ratio …