Digital Commons Network^™

Dissecting The Complex Genomic Landscape Underlying Oxidative Stress Resistance Using Natural Variation In Yeast, Sonali Lakshika Anne Lenaduwe

Graduate Theses and Dissertations

Stress is experienced across the tree of life. Survival in fluctuating environments depends on a robust genetic architecture. This dissertation examines the genetic and metabolic determinants underlying one such adaptive response: cross-protection. Leveraging natural variation in the stress responses of budding yeast, Saccharomyces cerevisiae, I examine the genetic variation contributing to ethanol-induced cross-protection against oxidative stress. Acquired stress resistance, in which mild pre-exposure improves survival to subsequent stresses, is prevalent across diverse organisms and can involve both same-stress and cross-protection. Using high-throughput bulk segregant analysis (BSA-seq) and advanced intercross mapping populations derived from natural yeast isolates, I identify quantitative trait …

Study On The Effects Of Molecular Layer Deposition Coating And Mechanical Pressure On Lithium Metal Anodes, Cameron Mondl

Graduate Theses and Dissertations

Lithium (Li) metal is a highly promising anode material for next-generation energy storage systems due to its outstanding theoretical capacity and low electrochemical potential. However, its commercialization implementation has been hindered due to interfacial instability and uncontrollable dendrite formation, leading to poor cycling efficiency and thermal runaway. Among the most promising stabilization strategies, protective interfacial coatings have emerged as an effective solution to promote more uniform Li deposition and suppress erratic morphological inconsistencies. In particular, molecular layer deposition (MLD) enables uniform film thickness through layer-by-layer deposits, offering a highly versatile approach to protective interfacial layers. In addition to interfacial engineering, …

Developmental Mathematics As A Potential Barrier To Degree Completion In Community Colleges, Cynthia Bernice Fletcher

Graduate Theses and Dissertations

Developmental mathematics is often seen as a barrier to student progression in community colleges, especially for students pursuing Associate of Science degrees requiring math coursework. This quantitative, ex post facto, non-experimental study examined how developmental mathematics factors predicted Associate of Science degree completion at a two-year community college in the West South-Central United States. Specifically, it assessed how academic performance in developmental mathematics, placement method, math pathway, and number of developmental math courses related to Associate of Science degree completion, as well as differences across student subgroups. Archival institutional data were used for first-time-in-college students across four cohorts: 2018, 2019, …

Hitler's Foreign Legions: Non-German Recruitment And Formations In The Waffen Ss, Jacob O'Bannon

Graduate Theses and Dissertations

During the Nazi regime, the armed bodyguard of the National Socialist Party the, the SS grew rapidly and eventually recruited foreign manpower. This thesis analyzes the rapid expansion of the SS as an armed military force and traces their forays into non-German states to recruit as the demands of World War II increased. The SS fielded thirty-eight divisions by the end of the war with hundreds of thousands of members not being from Germany. This rapid expansion, undertaken with soldiers from a variety of backgrounds, created a series of fractures between the ideological tenets of the SS and their practices. …

You Can Get Your Mail Sent There While You’Re Sleeping On The Street: A Community-Forward Analysis On The Role And Function Of The Northwest Arkansas Non-Profit Industry, Kaci Churchill

Graduate Theses and Dissertations

Nonprofit services are frequently sought by community members experiencing material hardship, particularly at junctures where employment- and state-based compensation fail to provide sufficiently. While barriers to aid provision have been examined from the perspective of nonprofits, various accessibility issues for community members seeking to obtain support are an under evaluated factor that influence the efficacy of nonprofits in carrying forth their mission. This qualitative study seeks to understand commonly experienced barriers to support facing resource-seeking community members. Semi-structured interviews with Northwest Arkansas community members, a region highly saturated with well-funded nonprofit agencies, shed light on recurring obstacles, and provide theoretical …

Genre Prediction Using Rnns And Llm-Enhanced Video Game Review Data, Gabriel Young

Graduate Theses and Dissertations

LLMs (Large Language Models) are powerful tools for engaging with textual data, carrying many advantages over classical NLP (Natural Language Processing) and ML (Machine Learning) approaches. However, a classical ML model can still be faster, more efficient to run, and accessible than an LLM. We seek to gain the benefits of LLM text comprehension and preserve them in a classical ML model, a hybrid approach. The LLM operates on text to surface relevant information and associations in our problem space, then the ML model trains on the LLM output. The model may learn from the LLM and provide a more …

Integrating People And Technology: Exploring The Validation Of The King And Hughes Hrd, Technology Ethics, And Leadership Scale, Hannah King

Graduate Theses and Dissertations

People and technologies have coexisted within organizations for centuries. In the wave of the fourth and fifth industrial revolutions, however, organizations must place an emphasis on ethically integrating new technologies, like artificial intelligence, alongside people in order to sustain a competitive advantage in the marketplace. A review of the literature identified a need for more research examining ethics in the use of technology by HRD professionals. The purpose of this descriptive research study was to assess the relationship between HRD activities, ethics, and technology and examine the influence that an organization’s code of ethics has on their integration. This study …

Structural Relaxation In Glass-Forming Liquids At Extreme Pressure: Photon-Correlation Spectroscopy And Constrained Thermodynamic Surface Modeling, Kevin Wayne Lyon

Graduate Theses and Dissertations

Structural relaxation in glass-forming liquids is strongly dependent on both temperature and pressure, yet direct measurement of structural α-relaxation under multi-gigapascal compression has remained experimentally challenging. This work extends depolarized photon correlation spectroscopy (DPCS) to pressures approaching 5 GPa in a diamond anvil cell, representing the highest-pressure implementation of this technique and enabling direct measurement of the structural α-relaxation in a pure liquid at extreme compression. This capability provides access to dynamical regimes previously unexplored by photon correlation spectroscopy and establishes a platform for probing glassy dynamics at high pressure. To describe these measurements, a constrained relaxation-time surface framework is …

An Efficient Implementation Of Gibbs-Duhem Integration For Solid-Liquid Phase Coexistence In Binary Lennard-Jones System With Relevance To Aav Capsid Separation, Muhi Muntaka

Graduate Theses and Dissertations

Gene therapy using adeno-associated viruses (AAVs) holds promise for treating genetic diseases, but high manufacturing costs limit its widespread use. A major challenge is separating functional (full) AAV capsids from non-functional (empty) ones, which are produced in similar amounts and have nearly identical structures. Conventional purification methods, such as density gradient ultracentrifugation and chromatography, face drawbacks like low yield, poor scalability, and high cost, often requiring multi-step processes. Recently, selective crystallization has emerged as a promising alternative, offering improved efficiency, scalability, and product quality. However, optimizing this method requires a deep understanding of thermodynamic phase behavior in multicomponent systems. In …

Understanding How Ai Chatbots Act As Gatekeepers When Recommending Destinations, Ayden Alexandra Carmack

Graduate Theses and Dissertations

As artificial intelligence chatbots become a primary tool for travel discovery, questions arise about whose destinations get recommended and how. This study examines how ChatGPT (OpenAI), Claude (Anthropic), and Google Gemini function as algorithmic gatekeepers in travel recommendations, drawing on gatekeeping theory, framing theory, and growing scholarship on AI bias in tourism. Using a content analysis of 135 AI-generated responses to 15 standardized travel prompts (45 per platform, each run three times) this study coded destination selection patterns, dominant narrative frames, and informational omissions across platforms. Results show that 88.9% of recommended destinations were classified as high-income nations, with Japan, …

From Phenology To Yield Zones: Functional Clustering Of Satellite Time Series For Crop Growth Monitoring, Ikram Morso

Graduate Theses and Dissertations

Remote sensing and land surface phenology provide a strong basis for characterizing crop development, but their usefulness for within-field yield-zone delineation depends on whether crop development is analyzed as a phenological trajectory and whether the resulting zones are evaluated with spatially defensible statistics. These questions are especially relevant in soybean production because soybean is one of the most important row crops in the United States and the country’s dominant oilseed crop. This relevance is strong in Arkansas, where soybean is a major component of agricultural production. In soybean production, within-field yield variability reflects the combined influence of soil properties, stand …

Validation Of Rice Tissue Sampling For In-Season Nutrient Management Of Nitrogen, Phosphorus, And Potassium, Tanner Smith

Graduate Theses and Dissertations

Nitrogen (N), phosphorus (P), and potassium (K) are the 3 most important nutrients involved in rice (Oryza sativa L.) growth and development. Tissue sampling has been proven to be a potential tool to provide inseason information about plant nutrient concentrations at specified timings and growth stages. With increased interest in tissue sampling and improving nutrient management effectiveness, more information is needed to validate plant tissue concentrations at which additional fertilizer inputs may be warranted. Experiments were conducted in 2024 and 2025 at the Rice Research and Extension Center (RREC) near Stuttgart, Ark.; Pine Tree Research Station (PTRS) near Colt, Ark.; …

Sel & Hil Integrations For Real-Time Cyber Threat Modeling, Risk Assessment, And Result Validation, Zachary Coel Harris

Graduate Theses and Dissertations

The electrical power grid is one of the most critical infrastructure systems, with virtually every other critical system relying on its electricity to operate effectively [1]. One failure in the electrical grid can have cascading effects, reducing, or outright stopping the operation of services vital to people’s lives. Ensuring continuous availability of the electrical grid is vital. This constant need for availability poses a challenge to identify potential cyber-attacks and their impacts. The grid is constantly growing with the addition of DERs (Distributed Energy Resources). Common DERs, such as photovoltaic systems or wind farms, can provide primary or secondary generation …

Lumbopelvic Kinematics And Muscular Co-Contractions In Walking Prior To And Immediately Following A Bout Of Prolonged Standing., Stephanie Cotariu

Graduate Theses and Dissertations

Background: Prolonged standing is a common daily activity in a wide array of occupations, and approximately 44% of sample populations develop low back pain (LBP) during prolonged standing. Prolonged standing-induced LBP developers (“Pain Developers”) are three times more likely to develop clinical LBP and can therefore be considered a pre-clinical LBP population. Changes in typical gait have been observed in LBP patients, and walking has been hypothesized as being protective or preventive against LBP development. However, it is unknown whether Pain Developers exhibit similar kinematic adaptations to chronic LBP patients during common daily activities, such as walking. The exact muscular …

Assessing The Potential Of Taming Chicken Gut Commensal Bacteria Using Random Transposon Mutagenesis, Arjun Chapagain

Graduate Theses and Dissertations

The chicken gut microbiome comprises hundreds of bacterial species whose functional roles remain largely unknown, in part because the tools needed to experimentally manipulate these organisms in their native community context have not been systematically developed or validated. This dissertation addresses the gap through three connected research chapters that progressively build a framework for transposon-based genetic delivery in the chicken cecal microbiome, moving from community-wide accessibility mapping to vector optimization to library preparation refinement. In Chapter 2, we established the community-level insertion landscape in chicken cecal metagenome using Himar transposon delivery via RP4 conjugation and aligned Tn-seq reads to a …

Solid Embedded Telemetry, Pranav Balasubramanian Natarajan

Graduate Theses and Dissertations

This thesis explores the integration of the Solid decentralized data framework within embedded and legacy energy control systems to enable secure, access-controlled, and interoperable data exchange. Two implementations were developed to evaluate Solid’s practical applicability: an ESP32 client implementing Solid-OIDC authentication and telemetry publication to a Solid Pod, and a Modbus-to-Solid bridge translating Modbus RTU communications into RDF-based data for bidirectional control. Experimental evaluation highlighted the effects of task scheduling and blocking operations on the ESP32, and polling-based communication latency within the Modbus bridge. These findings reveal the architectural and computational trade-offs involved in extending Solid to constrained or protocol-bound …

Effects Of Wetting And Drying On Nutrient Mobilization In Aquatic Systems, Karessa Grace De La Paz

Graduate Theses and Dissertations

Wetting and drying cycles are a fundamental, but underexplored, control on nutrient mobilization and transport in aquatic ecosystems. Such intermittency impacts approximately 60% of the world's streams and rivers, and the extent is expected to increase with future climate change. Additionally, aging reservoir infrastructure is driving restoration efforts, like large-scale drawdowns, that can expose benthic sediments to extended dry periods before refilling. Despite the prevalence of wet-dry cycles, how they influence nutrient transport and mobilization across different aquatic ecosystems remains poorly understood. To address this gap, this thesis presents two complementary studies exploring nutrient dynamics in Arkansas aquatic ecosystems that …

Recovery And Evaluation Of A Germanium Infrared Camera, Michael Paszek

Graduate Theses and Dissertations

Short-wave infrared imagers made of germanium are a promising way to extend silicon-compatible imaging beyond the visible spectrum. They also use mature CMOS fabrication and readout electronics. This thesis details the recovery, initialization, and evaluation of a germanium focal plane array (FPA) infrared camera system using both a sealed TriWave camera and a modular prototype platform. Functionality was restored to this legacy hardware, and repeatable testing workflows were established for evaluating packaged infrared imagers under controlled indoor and outdoor conditions. The prototype used a custom software interface named Merlott for evaluation, and it followed a standard sequence that included checking …

How Consumer Awareness Of Sustainability And Labor Practices Shape Fast Fashion Purchase Intentions, Sydney Smith

Graduate Theses and Dissertations

This study examines how consumer awareness of sustainability issues and unethical labor practices influences fast fashion purchase intentions. Grounded in the Theory of Planned Behavior and supported by the Symbolic Interaction Theory, the research explores how awareness, subjective norms, perceived behavioral control, and price sensitive shape consumer decision-making. A quantitative research design was employed using a self-administered online survey distributed via social media platforms. The final sample included 187 participants, and data were analyzed using descriptive statistics, correlation analyses, and multiple linear regression. Findings revealed that although participants reported moderate to high levels of awareness, this awareness did not significantly …

Entrepreneurial Ingenuity Of Buffalo's Brewers From 1870 To 1972, Olivia Harbol

History Theses

This thesis looks at Buffalo’s legacy breweries from 1870 to 1972.  Buffalo had a dynamic brewing past with over 30 breweries in existence on the eve of Prohibition. Buffalo’s breweries always displayed remarkable entrepreneurial ingenuity, which allowed them to adapt, change, and shift their businesses to survive. The brewers faced setbacks well before Prohibition ranging from fires to overcompetition to licensing challenges to outside brewers poaching their local markets. In covering Prohibition challenges, this thesis will only look at local brewers’ attempts to survive inside the law.  Plenty of work has already been done on illegal forms of coping.  In …

The Effect Of Hydroflow Devices On Calcium Carbonate Buildup., Holton Shults

Master of Engineering Theses

Water containing high levels of dissolved minerals, mainly calcium and magnesium, is known as hard water, which is commonly found across the world due to calcium’s abundance in the earth’s crust. Hard water can lead to calcium carbonate buildup (also referred to as limescale) that reduces flow, clogs pipes, and lowers heat exchanger efficiency, all of which can drive up costs. This work evaluated two commercially available chemical-free treatment devices from HydroFLOW USA LLC, called the Pearl Plus and s38 devices. These electromagnetic devices are designed to alter calcium carbonate crystal structure, potentially reducing the amount of calcium …

The Political Transformation Of Corporate America, 2001–2022, Reilly S. Steel

Faculty Scholarship

This article reconciles conflicting views about the political landscape of corporate America with new data on the revealed political preferences of 97,469 corporate directors and executives at 9,005 different U.S. companies. Driven largely by turnover, I find that average observed ideology for directors and executives has shifted meaningfully to the left over time, changing from modestly conservative in 2001 to roughly centrist by 2022. This finding supports a middle-ground position between conventional wisdom casting “big business” as a conservative stronghold and revisionist views holding the opposite. Counterfactual simulations and a difference-in-differences design suggest multifaceted reasons for these changes, and hand-collected …

Poor Esg: Regressive Effects Of Climate Stewardship, Zohar Goshen, Assaf Hamdani, Alex Raskolnikov

Faculty Scholarship

The rise of inequality and global warming are the two ultimate challenges of our time. After decades of congressional failure to address climate change, the private sector has stepped in and adopted a set of environmental, social, and governance (ESG) policies as a market-based solution to a public policy failure. ESG advocates hope that corporate executives would save our planet. Where Congress failed, ESG will succeed.

This Article argues that if ESG-driven climate stewardship ever achieves the scale necessary to have a real impact on global warming, it will hurt the poor. Legislative interventions to combat climate change are nearly …

Mechanisms Of Synergy Between Nanosecond Pulsed Electric Field (Nspef) And Cold Atmospheric Pressure Plasma Discharge (Cap) In Pancreatic Cancer: The Role Of Ros-Mediated Oxidative Stress And Apoptosis, Zobia Minhas

Biomedical Sciences Theses & Dissertations

Pancreatic ductal adenocarcinoma is a highly lethal malignancy characterized by poor prognosis and resistance to conventional therapies. Novel treatment strategies are needed to overcome this resistance. Non-thermal physical modalities, including nanosecond pulsed electric field (nsPEF) and cold atmospheric pressure plasma discharge (CAP), have emerged as potential anticancer approaches; however, the mechanisms underlying their combined effects remain unclear.

This study evaluated whether nsPEF enhances CAP-induced cytotoxicity and investigated the associated molecular mechanisms using the murine Pan02 pancreatic cancer cell line. Cell viability was assessed by WST-1 metabolic activity assays and electric cell–substrate impedance sensing (ECIS). Intracellular reactive oxygen species (ROS) were …

Adapt-On-Demand: Enabling Flexible And Scalable Adaptive Radiotherapy Through Workflow Automation, Sean Domal, Min Geon Choi, Justin Visak, Ruiqi Li, Taoran Li, Boon-Keng Kevin Teo, Xiaodong Zhao, Matthew Schmidt, Eric Laugeman, David Parsons, Yang Kyun Park, Shahed Badiyan, David Sher, Mu-Han Lin

2020-Current year OA Pubs

PURPOSE: CT-guided adaptive radiotherapy (CTgART) offers significant clinical benefits, but its utilization is often limited by resource demands and rigid workflows. This study presents a flexible and scalable "Adapt-on-Demand" (AOD) framework that integrates the adaptive capabilities of the Varian Ethos platform with the high-throughput IGRT delivery of the Varian Halcyon, supported by automated scripting.

METHODS: We developed an end-to-end dual-platform workflow that dynamically transitions between ART and IGRT delivery based on patient needs. Key components include Eclipse Scripting API (ESAPI) automation to streamline adapted plan ingestion from the Ethos Treatment Planning and Management System (TPMS) export directory, compatibility conversion for …

Preterm Birth Increases Susceptibility To Hyperglycemia-Induced Kidney Injury With Sex-Specific Differences In Structural And Molecular Responses, Rachel K Dailey, Aleksandra Cwiek, Logan C Hamil, Sage Timberline, Ayyappa Kumar Sista Kameshwar, Masako Suzuki, Jaya Isaac, Kimberly Deronde, Mark Conaway, Kevin M Bennett, Edwin J Baldelomar, Matthew R Hoch, Kimberly J Reidy, Jennifer R Charlton

2020-Current year OA Pubs

BACKGROUND: Preterm birth increases the long-term risk of diabetes and chronic kidney disease (CKD), yet its impact on diabetic kidney disease (DKD) is unclear. We previously showed that male preterm mice with diabetes develop early features of DKD, including reduced podocyte density, decreased renin expression, activation of angiogenesis pathways, and impaired endothelial-podocyte signaling. Here, we examine whether preterm birth similarly accelerates DKD progression in female mice and compare structural and transcriptomic outcomes in the females to the prior male cohort to assess sex-specific differences.

METHODS: Preterm mice were delivered by Caesarean section at 19 days post conception (dpc) and term …

Sympathetic And Parasympathetic Ganglion Blocks For Treatment Of Long Covid-19 Symptoms: A Scoping Review, Abhay Tyagi, Khushboo Singh, Preet Mohinder Singh, Frederic J Gerges

2020-Current year OA Pubs

BACKGROUND: Long COVID-19 affects approximately 10-30% of individuals who are infected with SARS-CoV-2 and is associated with persistent functional impairment and reduced quality of life. The heterogeneous, multisystemic nature and nonspecific symptomatology of long COVID-19 makes its treatment challenging. This scoping review evaluates existing evidence on sympathetic and parasympathetic ganglion blocks as potential interventions for patients suffering from long COVID-19.

OBJECTIVE: Our primary objective was to assess the effectiveness of sympathetic and parasympathetic ganglion blocks in treating patients with long COVID-19 by identifying the most commonly reported symptoms, symptom response to different block regimens, and any adverse effects associated with …

Computational Fluid Dynamics-Based Risk Stratification Of Modified Blalock-Taussig-Thomas Shunt Thrombogenicity, Yi Qiao, Ethan Penn, Jacob Miller, Scott Bugenhagen, Ram Rohatgi, Kelsey Mercer, Blaire Kulp, Jinli Wang, Pirooz Eghtesady, Guy M Genin, Edon J Rabinowitz, David Bark

2020-Current year OA Pubs

BACKGROUND: The modified Blalock-Taussig-Thomas shunt (mBTTS) is a critical palliative procedure for infants with single-ventricle physiology, but thrombosis-related occlusion affects 8% to 12% of infants and carries nearly 50% mortality. Meanwhile, existing antithrombotic strategies fail to address the hemodynamic factors driving thrombosis, highlighting the need for a deeper understanding of flow dynamics in shunt failure.

OBJECTIVES: This study aims to identify how mBTTS geometry influences hemodynamics and thrombosis risk, providing quantitative guidance for surgical planning and shunt design optimization.

METHODS: We used patient-specific imaging data to test 54 idealized mBTTS configurations, systematically varying key geometric factors: pulmonary artery diameter, shunt …

A Covalent Allosteric Molecular Glue Suppresses Nrf2-Dependent Cancer Growth, Nilotpal Roy, Ilah Bok, Harit Panda, Dhaval P Bhatt, Emily M Wilkerson, Soma Saeidi, Paul Zolkind, Michael B Major, Et Al.

2020-Current year OA Pubs

UNLABELLED: The NRF2 transcription factor is constitutively active in cancer, in which it functions to maintain oxidative homeostasis and reprogram cellular metabolism. NRF2-active tumors exhibit NRF2 dependency and resistance to chemotherapy/radiotherapy (RT). In this study, we characterize VVD-065, a first-in-class NRF2 inhibitor that acts via an unprecedented allosteric molecular glue mechanism. In the absence of stress or mutation, NRF2 is rapidly degraded by the Kelch-like ECH-associated protein 1 (KEAP1)-cullin3 (CUL3) ubiquitin-ligase complex. VVD-065 specifically and covalently engages Cys151 on KEAP1, which in turn promotes KEAP1-CUL3 complex formation, leading to enhancement of NRF2 degradation. Previously reported Cys151-directed compounds decrease KEAP1-CUL3 interactions …

An Open-Label, Clinical Feasibility Study Of The Efficacy Of Remdesivir For Long-Covid, Helen Neilens, Victoria Allgar, Kayle-Anne Sands, Jade Chynoweth, Amber Lord, Paigan J Aspinall, Helen Hambly, Anton Barnett, Lindsay Skipper, Tom Bewick, Ian Maidment, Hairil Abdul Razak, Ruth Ashton, David Strain, Karen Knapp, Mark A Faghy

Peninsula Medical School

BACKGROUND: Long COVID (LC) affects around two million people in the UK and over 65 million people globally. Antiviral medications have shown positive effects in reducing the risk of progression to severe disease in high-risk patients during an acute SARS-CoV-2 infection and have improved outcomes in those living with LC. Research testing the feasibility and efficacy of antiviral medications is ongoing, and clinical trials should determine the use of Remdesivir and its impact on LC symptoms, patient-reported outcomes, quality of life and functional status.

METHODS: Seventy-two patients ≥ 18 years of age who have a confirmed LC diagnosis will be …