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Articles 123721 - 123750 of 1114252
Full-Text Articles in Entire DC Network
The Relevance Of Gender For Excellent Research And Innovation: An Opinion, Yvonne Galligan
The Relevance Of Gender For Excellent Research And Innovation: An Opinion, Yvonne Galligan
Irish Journal of Academic Practice
This piece argues that the integration of sex and/or gender in research improves the quality of the research, contributes to excellence in the research process and makes the outcomes beneficial to society.
A Virtual World For Troubleshooting Distributed Systems, Sundarrajan Raman
A Virtual World For Troubleshooting Distributed Systems, Sundarrajan Raman
Defensive Publications Series
An observerse is proposed, to provide users of cloud-based distributed systems with tools for streamlined debugging and root cause analysis. The observerse serves as an observability platform, incorporating aspects of virtual reality technology to help users efficiently navigate the system to resolve operational issues.
Using Code Review Repositories And Changelists To Train Large Language Models For Code Generation, Joseph Johnson Jr, Shiblee Hasan, Emmanouil Koukoumidis
Using Code Review Repositories And Changelists To Train Large Language Models For Code Generation, Joseph Johnson Jr, Shiblee Hasan, Emmanouil Koukoumidis
Defensive Publications Series
While large language models (LLMs) can generate code, training of such models has not made use of data generated during the collaborative code review process that is a standard part of software development. This disclosure describes techniques that utilize historical code review data (including reviewer comments and corresponding code edits) available within organization internal code repositories to train LLMs to generate code. The historical code review data can be used for model tuning, to train an LLM via reinforcement learning from human feedback (RLHF), and/or via prompt engineering. The trained model can be utilized to generate code starting from code …
The Contribution Of Intellectual Property Awarensss And The Motivation Of Comic Creators To Product Innovation, Ngurah Rangga Wiwesa, Rahmi Setiawati, Dani Bintang Apriliyanto, Wan Hartini Wan Zainodin Dr, Putri Anindya Ravinta
The Contribution Of Intellectual Property Awarensss And The Motivation Of Comic Creators To Product Innovation, Ngurah Rangga Wiwesa, Rahmi Setiawati, Dani Bintang Apriliyanto, Wan Hartini Wan Zainodin Dr, Putri Anindya Ravinta
Jurnal Sosial Humaniora Terapan
Comics are not only in the artistic sector but also in the industrial sector, which has economic value in society and is included in the creative industry. As works of creativity, the comic industry needs to be recognized as intellectual works that have economic value and receive legal protection. Therefore, it is necessary to know the role of awareness of intellectual property rights and the motivation of comic creators in innovating in developing their products and measuring understanding of comics as a part of the creative industry. The population of this research is high school/vocational school and university students in …
Splitting And Authorising Card Payments Across Multiple Users Online Via A Single Payment Token, Samuel Oliver
Splitting And Authorising Card Payments Across Multiple Users Online Via A Single Payment Token, Samuel Oliver
Defensive Publications Series
The present disclosure relates to a method for splitting and authorizing payments online using tokens. The present disclosure demonstrates how a token based on card or payment account reference of a cardholder can be used to trigger payments from multiple accounts to split the total transaction cost based on a set of pre-determined rules. The method allows users to link multiple payment accounts to a single lead token, which in turn can be used to make payments from said accounts according to a set of rules. Generating a single lead token, allows this payment splitting method to be used at …
Effects Of Sex And Estrous Cycle On Intravenous Oxycodone Self-Administration And The Reinstatement Of Oxycodone-Seeking Behavior In Rats, Nicole M. Hinds, Ireneusz D. Wojtas, Corinne A. Gallagher, Claire M. Corbett, Daniel F. Manvich
Effects Of Sex And Estrous Cycle On Intravenous Oxycodone Self-Administration And The Reinstatement Of Oxycodone-Seeking Behavior In Rats, Nicole M. Hinds, Ireneusz D. Wojtas, Corinne A. Gallagher, Claire M. Corbett, Daniel F. Manvich
Rowan-Virtua School of Osteopathic Medicine Departmental Research
The increasing misuse of both prescription and illicit opioids has culminated in a national healthcare crisis in the United States. Oxycodone is among the most widely prescribed and misused opioid pain relievers and has been associated with a high risk for transition to compulsive opioid use. Here, we sought to examine potential sex differences and estrous cycle-dependent effects on the reinforcing efficacy of oxycodone, as well as on stress-induced or cue-induced oxycodone-seeking behavior, using intravenous (IV) oxycodone self-administration and reinstatement procedures. In experiment 1, adult male and female Long-Evans rats were trained to self-administer 0.03 mg/kg/inf oxycodone according to a …
Simulated Mechanical Control Of Nitellopsis Obtusa Under Mesocosm Conditions, Alyssa M. Haram, Ryan M. Wersal
Simulated Mechanical Control Of Nitellopsis Obtusa Under Mesocosm Conditions, Alyssa M. Haram, Ryan M. Wersal
Biological Sciences Department Publications
Management efforts to control starry stonewort [Nitellopsis obtusa (Desvaux in Loiseleur) J. Groves] have been limited to stressing the thalli and have not been able to directly target the reproductive bulbils. Smaller-scale efforts such as the use of hand pulling can be employed, but hand pulling is not realistic for larger infestations. This research was conducted to test the effects of clipping stress on N. obtusa to provide a baseline for the effect of stress on the production of bulbils and the regrowth of thalli. Mesocosms were set up under greenhouse conditions to test the effects on N. obtusa of …
Budding Uninhibited By Benzimidazoles-1 (Bub1) Regulates Egfr Signaling By Reducing Egfr Internalization, Shyam Nyati, Grant Young, Corey Speers, Mukesh K. Nyati, Alnawaz Rehemtulla
Budding Uninhibited By Benzimidazoles-1 (Bub1) Regulates Egfr Signaling By Reducing Egfr Internalization, Shyam Nyati, Grant Young, Corey Speers, Mukesh K. Nyati, Alnawaz Rehemtulla
Radiation Oncology Articles
EGFR signaling initiates upon ligand binding which leads to activation and internalization of the receptor-ligand complex. Here, we evaluated if BUB1 impacted EGFR signaling by regulating EGFR receptor internalization and activation. BUB1 was ablated genomically (siRNA) or biochemically (2OH-BNPP1) in cells. EGF ligand was used to initiate EGFR signaling while disuccinimidyl suberate (DSS) was used for cross linking cellular proteins. EGFR signaling was measured by western immunoblotting and receptor internalization was evaluated by fluorescent microscopy (pEGFR (pY1068) colocalization with early endosome marker EEA1). siRNA mediated BUB1 depletion led to an overall increase in total EGFR levels and more phospho-EGFR (Y845, …
Biomat (Biomechanics Multiactivity Transformer) Model, Mohsen Sharifi Renani
Biomat (Biomechanics Multiactivity Transformer) Model, Mohsen Sharifi Renani
BioMAT (Biomechanics Multiactivity Transformer)
No abstract provided.
Sociocultural Barriers For Female Participation In Stem: A Case Of Saudi Women In Cybersecurity, Alanoud Aljuaid, Xiang Michelle Liu
Sociocultural Barriers For Female Participation In Stem: A Case Of Saudi Women In Cybersecurity, Alanoud Aljuaid, Xiang Michelle Liu
Journal of Cybersecurity Education, Research and Practice
The participation of women in Science, Technology, Engineering, and Mathematics (STEM) workforces is overwhelmingly low as compared to their male counterparts. The low uptake of cybersecurity careers has been documented in the previous studies conducted in the contexts of the West and Eastern worlds. However, most of the past studies mainly covered the Western world leaving more knowledge gaps in the context of Middle Eastern countries such as Saudi Arabia. Thus, to fill the existing knowledge gaps, the current study focused on women in Saudi Arabia. The aim of the study was to investigate the factors behind the underrepresentation of …
Psychological Perspectives On The Presentation Of Video Evidence: How Perceivers Weight What Is Seen And Unseen, Yael Granot, David Igliozzi
Psychological Perspectives On The Presentation Of Video Evidence: How Perceivers Weight What Is Seen And Unseen, Yael Granot, David Igliozzi
Psychology: Faculty Publications
Video evidence is proliferating in the courtroom, outpacing the incremental advances in policies governing its use. Psychological research on attention and perception indicates that people are vulnerable to numerous biases in how they interpret video. The dynamic format of such evidence directs attention in distinct ways, and the visual system selectively captures some pieces of information at the expense of others. Thus, perceivers who must make decisions about video evidence are vulnerable to overweighting the information they see, underweighting the information they do not see, and being overconfident about their interpretation of what they see. We marshal emerging research on …
A Rapid Cell-Free Expression And Screening Platform For Antibody Discovery, Andrew C Hunt, Bastian Vögeli, Ahmed O Hassan, Laura Guerrero, Weston Kightlinger, Danielle J Yoesep, Antje Krüger, Madison Dewinter, Michael S Diamond, Ashty S Karim, Michael C Jewett
A Rapid Cell-Free Expression And Screening Platform For Antibody Discovery, Andrew C Hunt, Bastian Vögeli, Ahmed O Hassan, Laura Guerrero, Weston Kightlinger, Danielle J Yoesep, Antje Krüger, Madison Dewinter, Michael S Diamond, Ashty S Karim, Michael C Jewett
2020-Current year OA Pubs
Antibody discovery is bottlenecked by the individual expression and evaluation of antigen-specific hits. Here, we address this bottleneck by developing a workflow combining cell-free DNA template generation, cell-free protein synthesis, and binding measurements of antibody fragments in a process that takes hours rather than weeks. We apply this workflow to evaluate 135 previously published antibodies targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including all 8 antibodies previously granted emergency use authorization for coronavirus disease 2019 (COVID-19), and demonstrate identification of the most potent antibodies. We also evaluate 119 anti-SARS-CoV-2 antibodies from a mouse immunized with the SARS-CoV-2 spike …
High-Temperature Phonon-Assisted Upconversion Photoluminescence Of Monolayer Wse2, Fengkai Meng, Xiaodong Yang, Jie Gao
High-Temperature Phonon-Assisted Upconversion Photoluminescence Of Monolayer Wse2, Fengkai Meng, Xiaodong Yang, Jie Gao
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Phonon-assisted up conversion photoluminescence (UPL) is an anti-Stokes process emitting photons of energy higher than the excitation photons, with up conversion energy gain provided by optical phonons. Atomically thin transition metal dichalcogenides provide a promising platform for exploring the phonon-assisted UPL process due to their strong phonon-exciton interactions. Here, high-temperature phonon-assisted UPL process in monolayer WSe2 is investigated, aiming to understand the role of phonon population and the number of phonons involved in the UPL process at elevated temperatures. It is demonstrated that the integrated intensity of UPL emission significantly increases by two orders of magnitude as the temperature rises …
Face Readers: The Frontier Of Computer Vision And Math Learning, Beverly Woolf, Margrit Betke, Hao Yu, Sarah Adel Bargal, Ivan Arroyo, John J. Magee Iv, Danielle Allessio, William Rebelsky
Face Readers: The Frontier Of Computer Vision And Math Learning, Beverly Woolf, Margrit Betke, Hao Yu, Sarah Adel Bargal, Ivan Arroyo, John J. Magee Iv, Danielle Allessio, William Rebelsky
Computer Science
The future of AI-assisted individualized learning includes computer vision to inform intelligent tutors and teachers about student affect, motivation and performance. Facial expression recognition is essential in recognizing subtle differences when students ask for hints or fail to solve problems. Facial features and classification labels enable intelligent tutors to predict students’ performance and recommend activities. Videos can capture students’ faces and model their effort and progress; machine learning classifiers can support intelligent tutors to provide interventions. One goal of this research is to support deep dives by teachers to identify students’ individual needs through facial expression and to provide immediate …
How Effective Are Seta Programs Anyway: Learning And Forgetting In Security Awareness Training, David Sikolia, David Biros, Tianjian Zhang
How Effective Are Seta Programs Anyway: Learning And Forgetting In Security Awareness Training, David Sikolia, David Biros, Tianjian Zhang
Journal of Cybersecurity Education, Research and Practice
Prevalent security threats caused by human errors necessitate security education, training, and awareness (SETA) programs in organizations. Despite strong theoretical foundations in behavioral cybersecurity, field evidence on the effectiveness of SETA programs in mitigating actual threats is scarce. Specifically, with a broad range of cybersecurity knowledge crammed into in a single SETA session, it is unclear how effective different types of knowledge are in mitigating human errors in a longitudinal setting. his study investigates how knowledge gained through SETA programs affects human errors in cybersecurity to fill the longitudinal void. In a baseline experiment, we establish that SETA programs reduce …
Private Equity Blues: Warner Music Group, Nonesuch Records, And Jazz In The Era Of Financialization, Dale Chapman
Private Equity Blues: Warner Music Group, Nonesuch Records, And Jazz In The Era Of Financialization, Dale Chapman
All Faculty Scholarship
Since the 1980s, the Nonesuch label, a longstanding subsidiary of the Warner Music Group (WMG), has become noteworthy for its steady market performance during a period of volatility for media multinationals. Nonesuch Records, having once been an adventurous boutique classical label under Teresa Sterne, has developed over the last three decades as a creatively idiosyncratic and commercially successful adult imprint under Robert Hurwitz, the erstwhile director of the Munich-based Edition of Contemporary Music jazz label. Nonesuch has not historically been understood as a jazz label, though it has served as a home for a few jazz acts, including Bill Frisell, …
Anonymity And Gender Effects On Online Trolling And Cybervictimization, Gang Lee, Annalyssia Soonah
Anonymity And Gender Effects On Online Trolling And Cybervictimization, Gang Lee, Annalyssia Soonah
Journal of Cybersecurity Education, Research and Practice
The purpose of this study was to investigate the effects of the anonymity of the internet and gender differences in online trolling and cybervictimization. A sample of 151 college students attending a southeastern university completed a survey to assess their internet activities and online trolling and cybervictimization. Multivariate analyses of logistic regression and ordinary least squares regression were used to analyze online trolling and cybervictimization. The results indicated that the anonymity measure was not a significant predictor of online trolling and cybervictimization. Female students were less likely than male students to engage in online trolling, but there was no gender …
Experimental Study: The Effect Of Pore Shape, Geometrical Heterogeneity, And Flow Rate On The Repetitive Two-Phase Fluid Transport In Microfluidic Porous Media, Seunghee Kim, Jingtao Zhang, Sangjin Ryu
Experimental Study: The Effect Of Pore Shape, Geometrical Heterogeneity, And Flow Rate On The Repetitive Two-Phase Fluid Transport In Microfluidic Porous Media, Seunghee Kim, Jingtao Zhang, Sangjin Ryu
Department of Civil and Environmental Engineering: Faculty Publications
Geologic subsurface energy storage, such as porous-media compressed-air energy storage (PM-CAES) and underground hydrogen storage (UHS), involves the multi-phase fluid transport in structurally disordered or heterogeneous porous media (e.g., soils and rocks). Furthermore, such multi-phase fluid transport is likely to repeatedly occur due to successive fluid injections and extractions, thus, resulting in cyclic drainage–imbibition processes. To complement our preceding study, we conducted a follow-up study with microfluidic pore-network devices with a square solid shape (Type II) to further advance our understanding on the effect of the pore shape (aspect ratio, Type I: 5–6 > Type II: ~1), pore-space heterogeneity (coefficient of …
Thermal Performance Of Thin-Shell Concrete Dome Structures, Daira Sofia Velasco Vega
Thermal Performance Of Thin-Shell Concrete Dome Structures, Daira Sofia Velasco Vega
Undergraduate Honors Theses
The objective of this research is to evaluate an insulated concrete thin-shell dome structure for thermal flux with various depths of soil coverings. Computational thermal analysis is performed to model temperature fluctuations inside a representative section of an experimental concrete dome structure during all four seasons of northern Utah. The results are compared against the baseline of a traditional insulated wood-framed building envelope and indicate that thermal flux is significantly reduced in the earth-sheltered concrete dome structure with foam on the outside of the concrete. The addition of soil dampens the amplitude of the flux and increases the time lag …
Customer Value Co-Creation: Environmental Sustainability As A Tourist Experience, Esi A. Elliot, Russell P. Adams, Ernest Kafui Kwasi Tsetse
Customer Value Co-Creation: Environmental Sustainability As A Tourist Experience, Esi A. Elliot, Russell P. Adams, Ernest Kafui Kwasi Tsetse
International Business and Entrepreneurship Faculty Publications
Increasingly, environmental sustainability has become an important consideration for customer value co-creation, which is collaboration between a firm-provider and its customers to jointly create value. Our research question is therefore “how does customer value co-creation (CVC) enhance environmental sustainability?” We argue that attention to CVC globally would significantly enhance environmental sustainability in emerging markets. The findings of the study revealed that firms that do not enhance customer engagement and their environmental sustainability will lose patronage. Secondly, the attitude of most of these tourists who continually visit unclean tourism destinations such as littered beaches and polluted water bodies would continue to …
Messaging Matters: Ideological Influence Online Year 3 Final Report, Matthew L. Jensen, Shane Connelly, Shaila Miranda, Hairong Song, Ares Boira Lopez, Cecilia Gordon, Joseph Stewart, National Counterterrorism Innovation, Technology, And Education Center
Messaging Matters: Ideological Influence Online Year 3 Final Report, Matthew L. Jensen, Shane Connelly, Shaila Miranda, Hairong Song, Ares Boira Lopez, Cecilia Gordon, Joseph Stewart, National Counterterrorism Innovation, Technology, And Education Center
Reports, Projects, and Research
Our objective is to provide Department of Homeland Security (DHS) decision-makers and associated partners with insights about processes extreme ideological groups use to recruit members, harness social identities, mobilize communication around issues, increase commitment to extremism, and incite violent action. Iterating between analyzing extremist microblog archives and lab experiments, our research team is systematically examining messaging content and strategies that foreshadow extreme cognitions, affect, and behaviors. This year's activities focus on English language content most germane to understanding domestic terrorism incidents that may occur within the U.S. Our work provides insights into how messaging content and strategies promoting and foreshadowing …
Can Video Comparison Facilitate Children's Stem Learning?, Alexis Rene Colwell
Can Video Comparison Facilitate Children's Stem Learning?, Alexis Rene Colwell
Theses and Dissertations
The goal of the current study was to examine the effectiveness of a video comparison activity in teaching 6- and 7-year-old children that a diagonal brace provides stability in structures, which is an important engineering principle. Children were randomly assigned to one of three groups: Comparison, Single Model, or No Training. The children in the Comparison group saw two metal towers in a training video where the researcher pushed on the towers to demonstrate that one was stable (diagonal brace tower), and one was unstable (horizontal crosspiece tower). Children in the Single Model group saw a video of the one …
Cast Iron Repair Through Directed Energy Deposition And Ancillary Processing Modes, Jakob D. Hamilton
Cast Iron Repair Through Directed Energy Deposition And Ancillary Processing Modes, Jakob D. Hamilton
Theses
A cast iron repair process that restores above 80% of the original tensile strength without thermal pre-conditioning is presented. Cast iron, an integral alloy to transportation and agricultural sectors, is a difficult alloy to repair owing to the presence of discrete graphite flakes and the tendency to form brittle iron-carbide phases and porosity. Preheating and post-process annealing assist in preventing premature fracturing but are economically and environmentally impractical for large castings. Thus, methods that circumvent these limitations while avoiding defect formation are crucial. Laser-based directed energy deposition (DED) offers a highly controllable method of remanufacturing cast iron and high carbon …
Presence And Identity Of Babesia Microti In Ireland, A. Zintl, A. Mcmanus, M. Galan, M. Diquattro, L. Giuffredi, N. Charbonnel, J. Gray, C. Holland, Peter Stuart
Presence And Identity Of Babesia Microti In Ireland, A. Zintl, A. Mcmanus, M. Galan, M. Diquattro, L. Giuffredi, N. Charbonnel, J. Gray, C. Holland, Peter Stuart
Publications
Babesia microti is a tick-transmitted protozoan parasite of wildlife that can also cause serious disease in humans. It is now well established that B. microti represents an assemblage of different strains or species, only some of which are important zoonotic pathogens. Therefore, in order to assess the potential public health risk associated with B. microti in any given location, it is important to determine the strains that are present. This is the first study on the presence and identity of B. microti in Ireland. Overall, 314 wood mice (Apodemus sylvaticus), 243 bank voles (Myodes glareolus) and 634 questing Ixodes ricinus …
Compete To Learn: Toward Cybersecurity As A Sport, Tj Oconnor, Dane Brown, Jasmine Jackson, Bryson Payne, Suzanna Schmeelk
Compete To Learn: Toward Cybersecurity As A Sport, Tj Oconnor, Dane Brown, Jasmine Jackson, Bryson Payne, Suzanna Schmeelk
Journal of Cybersecurity Education, Research and Practice
To support the workforce gap of skilled cybersecurity professionals, gamified pedagogical approaches for teaching cybersecurity have exponentially grown over the last two decades. During this same period, e-sports developed into a multi-billion dollar industry and became a staple on college campuses. In this work, we explore the opportunity to integrate e-sports and gamified cybersecurity approaches into the inaugural US Cyber Games Team. During this tenure, we learned many lessons about recruiting, assessing, and training cybersecurity teams. We share our approach, materials, and lessons learned to serve as a model for fielding amateur cybersecurity teams for future competition.
Editorial - 2023 - 1, Hossain Shahriar, Herbert J. Mattord, Michael E. Whitman
Editorial - 2023 - 1, Hossain Shahriar, Herbert J. Mattord, Michael E. Whitman
Journal of Cybersecurity Education, Research and Practice
No abstract provided.
Examination Of Cybersecurity Technologies, Practices, Challenges, And Wish List In K-12 School Districts, Florence Martin, Julie Bacak, Erik Jon Byker, Weichao Wang, Jonathan Wagner, Lynn Ahlgrim-Delzell
Examination Of Cybersecurity Technologies, Practices, Challenges, And Wish List In K-12 School Districts, Florence Martin, Julie Bacak, Erik Jon Byker, Weichao Wang, Jonathan Wagner, Lynn Ahlgrim-Delzell
Journal of Cybersecurity Education, Research and Practice
With the growth in digital teaching and learning, there has been a sharp rise in the number of cybersecurity attacks on K-12 school networks. This has demonstrated a need for security technologies and cybersecurity education. This study examined security technologies used, effective security practices, challenges, concerns, and wish list of technology leaders in K-12 settings. Data collected from 23 district websites and from interviews with 12 district technology leaders were analyzed. Top security practices included cloud-based technologies, segregated network/V-LAN, two-factor authentication, limiting access, and use of Clever or Class Link. Top challenges included keeping users informed, lack of buy-in from …
A Systematic Mapping Study On Gamification Applications For Undergraduate Cybersecurity Education, Sherri Weitl-Harms, Adam Spanier, John Hastings, Matthew Rokusek
A Systematic Mapping Study On Gamification Applications For Undergraduate Cybersecurity Education, Sherri Weitl-Harms, Adam Spanier, John Hastings, Matthew Rokusek
Journal of Cybersecurity Education, Research and Practice
Gamification in education presents a number of benefits that can theoretically facilitate higher engagement and motivation among students when learning complex, technical concepts. As an innovative, high-potential educational tool, many educators and researchers are attempting to implement more effective gamification into undergraduate coursework. Cyber Security Operations (CSO) education is no exception. CSO education traditionally requires comprehension of complex concepts requiring a high level of technical and abstract thinking. By properly applying gamification to complex CSO concepts, engagement in students should see an increase. While an increase is expected, no comprehensive study of CSO gamification applications (GA) has yet been undertaken …
Electrically-Evoked Referred Sensations Induce Embodiment Of Rubber Limb, Anthony Nguyen, Brooke Draggoo, Brooklyn Tobias, Payton Dubose, Katharine Polasek
Electrically-Evoked Referred Sensations Induce Embodiment Of Rubber Limb, Anthony Nguyen, Brooke Draggoo, Brooklyn Tobias, Payton Dubose, Katharine Polasek
Faculty Publications
Introduction: Electrical stimulation is increasingly relevant in a variety of medical treatments. In this study, the quality of referred sensations evoked using surface electrical stimulation was evaluated using the rubber hand and foot illusions.
Methods: The rubber hand and foot illusions were attempted under 4 conditions: (1) multi-location tapping; (2) one-location tapping; (3) electrical stimulation of sensation referred to the hand or foot; (4) asynchronous control. The strength of each illusion was quantified using a questionnaire and proprioceptive drift, where a stronger response suggested embodiment of the rubber limb.
Results: 45 able-bodied individuals and two individuals with amputations participated in …
Age-Related Alterations In Meningeal Immunity Drive Impaired Cns Lymphatic Drainage, Justin Rustenhoven, Georgios Pavlou, Steffen E Storck, Taitea Dykstra, Siling Du, Zhengpeng Wan, Daniel Quintero, Joshua P Scallan, Igor Smirnov, Roger D Kamm, Jonathan Kipnis
Age-Related Alterations In Meningeal Immunity Drive Impaired Cns Lymphatic Drainage, Justin Rustenhoven, Georgios Pavlou, Steffen E Storck, Taitea Dykstra, Siling Du, Zhengpeng Wan, Daniel Quintero, Joshua P Scallan, Igor Smirnov, Roger D Kamm, Jonathan Kipnis
2020-Current year OA Pubs
The meningeal lymphatic network enables the drainage of cerebrospinal fluid (CSF) and facilitates the removal of central nervous system (CNS) waste. During aging and in Alzheimer's disease, impaired meningeal lymphatic drainage promotes the buildup of toxic misfolded proteins in the CNS. Reversing this age-related dysfunction represents a promising strategy to augment CNS waste clearance; however, the mechanisms underlying this decline remain elusive. Here, we demonstrate that age-related alterations in meningeal immunity underlie this lymphatic impairment. Single-cell RNA sequencing of meningeal lymphatic endothelial cells from aged mice revealed their response to IFNγ, which was increased in the aged meninges due to …