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Atomistic Simulations Of Twin Facets Associated With Three-Dimensional { []011 } Twins In Magnesium, Qiyu Zeng, Mingyu Gong, Houyu Ma, Yao Shen, Jian-Feng Nie, Jian Wang, Yue Liu Jul 2023

Atomistic Simulations Of Twin Facets Associated With Three-Dimensional { []011 } Twins In Magnesium, Qiyu Zeng, Mingyu Gong, Houyu Ma, Yao Shen, Jian-Feng Nie, Jian Wang, Yue Liu

Department of Mechanical and Materials Engineering: Faculty Publications

Twinning is a deformation mechanism that creates three-dimensional (3D) twin domains through the migration of twin facets. This occurs via the nucleation and glide of twinning disconnections (TDs), which can pile up to create twin facets. A comprehensive under- standing of twin facets associated with 3D twins, including their atomic structures and energies, is crucial for understanding deformation twinning. In this study, we propose a molecular statics/dynamics (MS/MD) approach to determine characteristic twin facets enclosing 3D non-equilibrium/equilibrium { [] 011 } twin domains, which has been much less studied than the counterpart { [] 012 } twin domains. The stability …


Triverus Infiltration And Cleaning Report 2023, Unh Stormwater Center Jul 2023

Triverus Infiltration And Cleaning Report 2023, Unh Stormwater Center

UNH Stormwater Center

No abstract provided.


Advancements In Middle School Agricultural Education: An Examination Of Emerging Trends And Exemplary Programs, Jacob P. Englin Jul 2023

Advancements In Middle School Agricultural Education: An Examination Of Emerging Trends And Exemplary Programs, Jacob P. Englin

LSU Master's Theses

Recent trends in agricultural education have demonstrated that the number of middle school programs and students has been increasing. Despite this, middle school agricultural education students, teachers, and programs often have been considered to be underserved. For example, teachers at this level have expressed that they often lacked the training and resources to meet the needs of this diverse learning population. Even so, middle school agricultural education teachers have continued to provide quality learning experiences for their students. In response, this investigation’s purpose was to examine current trends of middle school agricultural education and the quality of learning conducted by …


Development And Testing Of A Mapcheck3-Based Patient-Specific Qa Method For Prime Intensity Modulators Used With Bolus Electron Conformal Therapy, James T. Crist Jul 2023

Development And Testing Of A Mapcheck3-Based Patient-Specific Qa Method For Prime Intensity Modulators Used With Bolus Electron Conformal Therapy, James T. Crist

LSU Master's Theses

Purpose: Irregular surfaces in bolus electron conformal therapy (BECT) create target volume dose inhomogeneity, which off-axis intensity modulation (IM) can reduce. This research developed and tested a patient-specific clinical quality assurance (QA) procedure for fabricated Passive Radiotherapy Intensity Modulation for Electrons (PRIME) devices used for IM-BECT delivery.

Methods: To evaluate MapCheck3 (MC3) diode array accuracy, electron dose measurements beneath PRIME devices were compared with scanned measurements in a water phantom. Lateral dose profile comparisons were made for 35 combinations of five beam energies (7-20MeV) and seven PRIME devices - converging and diverging island blocks (pins) having 100-68.8% intensities. To evaluate …


Gender (In)Equity In Global Mental Health Research: A Call To Action, The Women In Global Mental Health Research Group, Kelly Rose-Clarke Jul 2023

Gender (In)Equity In Global Mental Health Research: A Call To Action, The Women In Global Mental Health Research Group, Kelly Rose-Clarke

Faculty Publications

In this commentary, we build on work by Gurung and colleagues which highlighted gender inequity in the global mental health research workforce in Nepal (Gurung et al., 2021). We seek to increase awareness of the under-representation of women in global mental health research and its consequences, and we call for change. By women, we refer to all people who identify as women, including trans people. The commentary is informed by conversations with women who are global mental health researchers in the Global North and South at various stages of their careers.


Impact Of Social Emotional Learning On Exclusionary Discipline, Joanna T. Carrillo Rowley Jul 2023

Impact Of Social Emotional Learning On Exclusionary Discipline, Joanna T. Carrillo Rowley

Education Theses and Dissertations

A middle school campus in a Southeast urban community used a Plan-Do-Study-Act (PDSA) Cycle, an inquiry method in improvement science, to address high exclusionary discipline rates by implementing Social Emotional Learning (SEL) strategies and Restorative Practices (RP) to transform school culture. A reform to a comprehensive discipline program was developed to minimize the amount of exclusionary discipline outcomes (in-school suspension [ISS], out-of- school suspension [OSS], and expulsion) among students while increasing student attendance rates, student achievement, and teacher retention. Three distinct cycles will be examined, each concentrating on a different problem of practice and intervention. These methods were introduced, practiced, …


Using Active Student Responding And Competition Via Kahoot! To Improve Student Academic Engagement At College Level, Brittany Pearson Jul 2023

Using Active Student Responding And Competition Via Kahoot! To Improve Student Academic Engagement At College Level, Brittany Pearson

USF Tampa Graduate Theses and Dissertations

Active student responding (ASR) is an effective intervention used in schools to improve student engagement and academic performance. Among the various ASR modalities, online applications have received much more attention than low-tech ASR modalities due to the widespread use of smartphones and the availability of mobile applications. One totable online application is Kahoot!, which offers a range of interactive features. Considering the limited existing research on using ASR at the college level, particularly, using Kahoot!, this study examined the use of Kahoot! to improve academic engagement in college students. The study was conducted with one undergraduate class in applied behavior …


Neural Network Models For Generating Synthetic Flight Data, Nathaniel Sisson Jul 2023

Neural Network Models For Generating Synthetic Flight Data, Nathaniel Sisson

Doctoral Dissertations and Master's Theses

Flight test data is a valuable resource used in many aerospace applications. However, procuring a sufficiently large database of flight test data poses several challenges. Nominal flight tests can be expensive and time-consuming and require much post-processing depending on the availability of sensors and the quality of the sensor output. Flight test performed outside of nominal flight conditions, or flight tests in which failures are introduced, add to the inherent risk and danger associated with flight tests. The most popular alternative to flight test, numerical simulations, may fail to fully capture all non-linear behavior. While flight tests will always be …


Digitally Rethinking Hunter V Southam, Lisa M. Austin, Andrea Slane Jul 2023

Digitally Rethinking Hunter V Southam, Lisa M. Austin, Andrea Slane

Osgoode Hall Law Journal

Lawful access—the legal regime that authorizes various methods used by law enforcement to intercept, search, or seize information for investigatory purposes—has been subject to much debate in Canada. However, those debates need a new solution space for the digital age. This must be able to incorporate new technological solutions for minimizing rights infringements and provide new forms of accountability and safeguards against misuse. This is not simply a matter of adopting the popular framework of “privacy by design,” or even a reworked “lawful access by design.” We argue that an appreciation of the challenges of the digital world requires us …


Promoting National Unity In Nigeria: The Roles Of Library And Information Professionals., Marcus Oladotun Aragbaye, Blessing Oyemah John, Emmanuel Akande Jul 2023

Promoting National Unity In Nigeria: The Roles Of Library And Information Professionals., Marcus Oladotun Aragbaye, Blessing Oyemah John, Emmanuel Akande

Library Philosophy and Practice (e-journal)

This study explores the importance of national unity in Nigeria and how it can lead to progress. Library professionals can play a key role in promoting diversity and inclusivity, which are essential for peaceful coexistence. National unity can be achieved through common goals, open communication, and collaboration. Access to timely and accurate information is also crucial in achieving social cohesion. The study highlights the responsibilities of LIS professionals in promoting national unity, such as ethical standards, financial information and vocational training, providing authorized sources of information, incorporating Indigenous knowledge into the curriculum, among other things. Collaboration between government agencies and …


Board Of Directors Meeting Minutes (July 10, 2023), Dmacc Jul 2023

Board Of Directors Meeting Minutes (July 10, 2023), Dmacc

Board of Directors Meeting Minutes

This file contains the minutes from the Des Moines Area Community College Board meeting held on July 10, 2023.


Microfabrication Of Silicon Carbide And Metallized Polymers Using A Femtosecond Laser, Joseph Taylor Eddy Jul 2023

Microfabrication Of Silicon Carbide And Metallized Polymers Using A Femtosecond Laser, Joseph Taylor Eddy

Theses and Dissertations

Femtosecond lasers deliver a high peak concentration of optical power while maintaining low average power. With an accompanying optical setup, this power can be focused and used for high-precision fabrication of metallized polymers via ablation, creating conductive structures on a thin film. These lasers can also be harnessed in tandem with hydrofluoric acid and the two-photon absorption principle to selectively etch silicon carbide, a very durable and machining-resistant semiconductor with desirable properties. This thesis presents improvements made to the Laser-Assisted Chemical Etching (LACE) technique and the ablation system. ��, the two- photon absorption coefficient of silicon carbide, is measured and …


Holocene Rice Rats (Genus Oryzomys) From The Upper Mississippi River Drainage Basin, Hugh H. Genoways Jul 2023

Holocene Rice Rats (Genus Oryzomys) From The Upper Mississippi River Drainage Basin, Hugh H. Genoways

Zea E-Books Collection

The expansion and collapse of the geographic range of the Texas rice rat (Oryzomys texensis) in the upper Mississippi River drainage basin at the end of the Holocene was a unique event in North American mammals. In a period of about 4000 years with a point of origin near the American Bottom in Illinois, these small rodents extended their geographic range in a straight-line distance of over 950 km to the west into Nebraska and the same distance to the east into Pennsylvania. Then in less than 400 years this range expansion collapsed back to a point where …


Mitigating Landslide Hazards In Qena Governorate Of Egypt: A Gis-Based Neutrosophic Paprika Approach, Nabil M. Abdelaziz, Safa Al-Saeed Jul 2023

Mitigating Landslide Hazards In Qena Governorate Of Egypt: A Gis-Based Neutrosophic Paprika Approach, Nabil M. Abdelaziz, Safa Al-Saeed

Neutrosophic Systems with Applications

This paper presents a novel approach to landslide susceptibility assessment in the Qena Governorate, Egypt, integrating the neutrosophic Multi-Criteria Decision-Making (MCDM) method, the Potentially All Pairwise RanKings of all possible Alternatives (PAPRIKA), and the ArcGIS weighted overlay technique. The research focuses on the quantification and prioritization of eight criteria: slope, aspect, proximity to road, soil type, proximity to river, land cover, elevation, and Lithology. These factors are evaluated under the uncertainty and indeterminacy of the neutrosophic environment by employing the PAPRIKA method. The results of the analysis are visualized and interpreted using ArcGIS weighted overlay, offering spatially explicit insights into …


The Effect Of Heat Treatment And Chemical Treatment On Natural Fibre To The Durability Of Wood Plastic Composites – A Review, Nuratiqah Asyiqin Mohd Nasharudin, Nur Fatihah Sulaiman, Nurul Aziemah Mohammad, Wan Nor Raihan Wan Jaafar, Falah Abu Dr., Siti Norasmah Surip Jul 2023

The Effect Of Heat Treatment And Chemical Treatment On Natural Fibre To The Durability Of Wood Plastic Composites – A Review, Nuratiqah Asyiqin Mohd Nasharudin, Nur Fatihah Sulaiman, Nurul Aziemah Mohammad, Wan Nor Raihan Wan Jaafar, Falah Abu Dr., Siti Norasmah Surip

Journal of Materials Exploration and Findings

The application of WPC is not only limited to indoor applications but has been extended to exterior applications where properties of WPC could compromise during service life. WPC was derived from wood fiber of various sizes to reinforce polymers. Wood fiber has the advantage of a cheaper price, being abundantly available, and ease of processing, however, the critical factor is its hydrophilic nature, where moisture absorption is likely to occur. Thus, treatments for reducing the hydrophilicity of wood fibers are applied. By treatment of wood fiber, the surface impurities were removed, leaving the roughened surface of fibers, thus providing a …


Myc Regulates Csf1 Expression Via Microrna 17/20a To Modulate Tumor-Associated Macrophages In Osteosarcoma, Ryan Shuck, Atreyi Dasgupta, Nino Rainusso, Cristian Coarfa, Jason T Yustein Jul 2023

Myc Regulates Csf1 Expression Via Microrna 17/20a To Modulate Tumor-Associated Macrophages In Osteosarcoma, Ryan Shuck, Atreyi Dasgupta, Nino Rainusso, Cristian Coarfa, Jason T Yustein

Faculty, Staff and Students Publications

Osteosarcoma (OS) is the most common primary bone tumor of childhood. Approximately 20%-30% of OSs carry amplification of chromosome 8q24, which harbors the oncogene c-MYC and correlates with a poor prognosis. To understand the mechanisms that underlie the ability of MYC to alter both the tumor and its surrounding tumor microenvironment (TME), we generated and molecularly characterized an osteoblast-specific Cre-Lox-Stop-Lox-c-MycT58A p53fl/+ knockin genetically engineered mouse model (GEMM). Phenotypically, the Myc-knockin GEMM had rapid tumor development with a high incidence of metastasis. MYC-dependent gene signatures in our murine model demonstrated significant homology to the human hyperactivated MYC OS. We established that …


Ηow To Use Artificial Intelligence (Ai) As A Resource, Methodological And Analysis Tool In Qualitative Research?, Prokopis Christou Jul 2023

Ηow To Use Artificial Intelligence (Ai) As A Resource, Methodological And Analysis Tool In Qualitative Research?, Prokopis Christou

The Qualitative Report

Artificial Intelligence (AI) has had far-reaching effects in research and the academic world. It has been used in many ways by the scientific community within the context of qualitative research, such as literature and systematic reviews, for conceptualization purposes, thematic and content analysis. It has however prompted concerns and questions about the potential for unreliable research, bias, and unethical behavior in the outcomes of AI-produced research. The purpose this paper is to examine the current use of AI in research, its strengths and limitations, dilemmas and ethical considerations from theoretical critical perspective principles, while delivering five key considerations for the …


Cationic Divalent Metal Sites (M = Mn, Fe, Co) Operating As Both Nitrene-Transfer Agents And Lewis Acids Toward Mediating The Synthesis Of Three- And Five-Membered N-Heterocycles, Suraj Kumar Sahoo, Brent Harfmann, Lin Ai, Qiuwen Wang, Sudip Mohapatra, Amitava Choudhury, Pericles Stavropoulos Jul 2023

Cationic Divalent Metal Sites (M = Mn, Fe, Co) Operating As Both Nitrene-Transfer Agents And Lewis Acids Toward Mediating The Synthesis Of Three- And Five-Membered N-Heterocycles, Suraj Kumar Sahoo, Brent Harfmann, Lin Ai, Qiuwen Wang, Sudip Mohapatra, Amitava Choudhury, Pericles Stavropoulos

Chemistry Faculty Research & Creative Works

The tripodal compounds [(TMG3trphen)MII-solv](PF6)2 (M = Mn, Fe, Co; solv = MeCN, DMF) and bipodal analogues [(TMG2biphen)MII(NCMe)x](PF6)2 (x = 3 for Mn, Fe; x = 2 for Co) and [(TMG2biphen)MIICl2] have been synthesized with ligands that feature a triaryl- or diarylmethyl-amine framework and superbasic tetramethylguanidinyl residues (TMG). The dicationic M(II) sites mediate catalytic nitrene-transfer reactions between the imidoiodinane PhI═NTs (Ts = tosyl) and a panel of styrenes in MeCN to afford aziridines and low yields of imidazolines (upon …


Differentials And Predictors Of Food Insecurity Among Federally Qualified Health Center Target Populations In Philadelphia: A Cross-Sectional Study, Galicano Kai Inguito, Brandon Joa, James Gardner, Eric N Fung, Laura Layer, Karen Fritz Jul 2023

Differentials And Predictors Of Food Insecurity Among Federally Qualified Health Center Target Populations In Philadelphia: A Cross-Sectional Study, Galicano Kai Inguito, Brandon Joa, James Gardner, Eric N Fung, Laura Layer, Karen Fritz

Department of Medicine Faculty Papers

BACKGROUND: Over the past decade, the prevalence of food insecurity declined in the United States but curiously climbed in Philadelphia, Pennsylvania, a sizable metropolitan area where many households experience food insecurity and are dependent on programs like SNAP. Therefore, we aimed to determine the burden of food insecurity among populations near Philadelphia Federally Qualified Health Center (FQHC) clinic sites.

METHODS: This cross-sectional study was conducted in North Philadelphia, a populous and impoverished section of Philadelphia with many zip codes reporting 30-45% or more of the population below the federal poverty line. Students and clinicians affiliated with a local FQHC conducted …


Re: Approval Letter For The Butte Priority Soils Operable Unit, Superfund Stormwater Operation And Maintenance (O&M); Mountain Con Sw Channel Diversion, Request For Change (Rfc)-Bsb Sitewide-2023-001 (Dated June 29, 2023), Nikia Greene Jul 2023

Re: Approval Letter For The Butte Priority Soils Operable Unit, Superfund Stormwater Operation And Maintenance (O&M); Mountain Con Sw Channel Diversion, Request For Change (Rfc)-Bsb Sitewide-2023-001 (Dated June 29, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Calibration Of The Johnson–Cook Model At High Temperatures For An Ultra-High Strength Crnimov Steel, Mario F. Buchely, S. Chakraborty, V. Athavale, Laura Bartlett, Ronald J. O'Malley, D. Field, K. Limmer, K. Sebeck Jul 2023

Calibration Of The Johnson–Cook Model At High Temperatures For An Ultra-High Strength Crnimov Steel, Mario F. Buchely, S. Chakraborty, V. Athavale, Laura Bartlett, Ronald J. O'Malley, D. Field, K. Limmer, K. Sebeck

Materials Science and Engineering Faculty Research & Creative Works

This paper presents a study on the thermo-mechanical behavior of an ultra-high strength CrNiMoV steel at high temperatures and medium strain rates through hot tensile tests. The material was examined in two conditions: as-cast/heat-treated (AC/HT) and as-rolled (AR). Tensile tests were conducted at temperatures of 800,900,1000,1100, and 1200°C, and strain rates of 0.1,1, and 10s−1. Inclusion and porosity analysis was also performed on the tensile specimens. The results revealed that the flow stress decreased by approximately 70% on average from 800°C to 1200°C, while increasing by approximately 32% on average from 0.1s−1 to 10s−1 in strain rate. The elongation exhibited …


Messages From The Provost, Georgia Southern University Jul 2023

Messages From The Provost, Georgia Southern University

Messages from the Provost

Unity in Diversity

Excellence in Action

Power in Knowledge

Fluent in Success

Presentation & Accolades


The Essential Work Of Fracture In Peridynamics, Christer Stenström, Kjell Eriksson, Florin Bobaru, Stefan Golling, Pär Jonsén Jul 2023

The Essential Work Of Fracture In Peridynamics, Christer Stenström, Kjell Eriksson, Florin Bobaru, Stefan Golling, Pär Jonsén

Department of Mechanical and Materials Engineering: Faculty Publications

In this work, the essential work of fracture (EWF) method is introduced for a peridynamic (PD) material model to characterize fracture toughness of ductile materials. First, an analytical derivation for the path-independence of the PD J -integral is provided. Thereafter, the classical J -integral and PD J-integral are computed on a number of analytical crack problems, for subsequent investigation on how it performs under large scale yielding of thin sheets. To represent a highly nonlinear elastic behavior, a new adaptive bond stiffness calibration and a modified bonddamage model with gradual softening are proposed. The model is employed for two …


Effect Of Internal Curing And Shrinkage-Mitigating Materials On Microstructural Characteristics Of Fiber-Reinforced Mortar, Kamran Aghaee, Kamal Khayat Jul 2023

Effect Of Internal Curing And Shrinkage-Mitigating Materials On Microstructural Characteristics Of Fiber-Reinforced Mortar, Kamran Aghaee, Kamal Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Internal curing (IC) and other shrinkage mitigating materials are employed to reduce shrinkage and risk of cracking. This study investigates the efficiency of individual versus combined use of IC and shrinkage mitigating materials on key characteristics of fiber-reinforced mortar (FRM). The investigated mixtures include a 25% pre-saturated lightweight sand (LWS) that is added individually and combined with 10% CaO-based expansive agent (EA) and 2% shrinkage reducing admixture (SRA). This elucidates the synergistic effect of high content IC and EA/SRA on macro- and micro-mechanical characteristics of FRM, especially at the interface of the matrix with fibers. Mechanical properties, microstructural characteristics, and …


An Authoethnographic Study Of My Biliteracy Writing Practices As An Akan Speaker Of English: Implications For L 2 Writing, Gabriel Opare Jul 2023

An Authoethnographic Study Of My Biliteracy Writing Practices As An Akan Speaker Of English: Implications For L 2 Writing, Gabriel Opare

Theses and Dissertations

In this thesis, I discuss my academic literacy socialization practices, particularly my linguistic and social adjustments in US graduate school. This autoethnographic study utilizes stories and evidentiality (corpus from my graduate school papers) as self-reflective epistemologies to understand my literate practices in a US academic discourse community. Contributing to the scholarship on the academic socialization of transnational graduate students in the US, I discuss and analyze my stories and experiences around academic writing practices in navigating graduate school's academic requirements and expectations in the context of higher education in the United States. By focusing on my lived experiences as a …


Quantifying Uncertainties In Direct-Numerical-Simulation Statistics Due To Wall-Normal Numerics And Grids, Peng E. S. Chen, Xiaowei Zhu, Yipeng Shi, Xiang I. A. Yang Jul 2023

Quantifying Uncertainties In Direct-Numerical-Simulation Statistics Due To Wall-Normal Numerics And Grids, Peng E. S. Chen, Xiaowei Zhu, Yipeng Shi, Xiang I. A. Yang

Mechanical and Materials Engineering Faculty Publications and Presentations

This paper takes the perspective of a user of direct-numerical-simulation (DNS) data and quantifies the uncertainties in DNS statistics for plane channel flows. We focus on high-order statistics, such as skewness, kurtosis, and viscous dissipation, and quantify the uncertainties due to wall-normal numerics and grids while minimizing the sampling error and the discretization error in the wall-parallel directions. Two grid distributions and four discretization methods are considered, which are representative of the existing DNSs. Our results show that the available DNS data contain at least a 7% uncertainty in the computed mean viscous dissipation in the buffer layer. Moreover, since …


On Teaching Multi-Criteria Decision Making With A Robot Assistant, Chen Zhang, Hakan Saraoglu, David A. Louton Jul 2023

On Teaching Multi-Criteria Decision Making With A Robot Assistant, Chen Zhang, Hakan Saraoglu, David A. Louton

Information Systems and Analytics Department Faculty Conference Proceedings

We propose a system and method for a robot assistant for teaching multi-attribute decision making (MCDM). Through questions and answers in natural language, the robot assistant learns the user’s preferences on multiple criteria involving a selection decision and makes recommendations using data on each criterion and the learned user preferences. It will include a use-case demonstration where NAO the robot will assist a human in forming a simple portfolio of mutual funds. Presenters will illustrate the architecture of the robot assisted MCDM and describe a method that is extensively used to structure complex decision problems and has been applied to …


Sportsman's Paradox: Conservationism And Social Progress In Modern Louisiana, Jacob T. Gautreaux Jul 2023

Sportsman's Paradox: Conservationism And Social Progress In Modern Louisiana, Jacob T. Gautreaux

LSU Doctoral Dissertations

Over the nineteenth and early twentieth centuries, sportsmen increasingly identified Louisiana as a destined paradise due to the abundant flora and fauna. Confirmed in the legendary visits of Theodore Roosevelt in the early 1900s, the conception soon served a dual purpose as individuals like the Tabasco Sauce patriarch, E. A. McIlhenny, coopted the visualization as a lure for business investment into the nascent industrial interests within the coastal region of the state. However, it should be noted that in the 1930s and beyond, cultural conservationists like McIlhenny and Caroline Dormon preserved elements of under-documented cultures throughout the state, although usually …


Mct4-Dependent Lactate Secretion Suppresses Antitumor Immunity In Lkb1-Deficient Lung Adenocarcinoma, Yu Qian, Ana Galan-Cobo, Irene Guijarro, Minghao Dang, David Molkentine, Fahao Zhang, Jing Wang, Edwin Parra, Apekshya Panda, Jacy Fang, Ferdinandos Skoulidis, Ignacio I Wistuba, Svena Verma, Taha Merghoub, Jedd D Wolchok, Kwok-Kin Wong, Ralph J Deberardinis, John D Minna, Natalie I Vokes, Catherine B Meador, Justin F Gainor, Linghua Wang, Alexandre Reuben, John V Heymach Jul 2023

Mct4-Dependent Lactate Secretion Suppresses Antitumor Immunity In Lkb1-Deficient Lung Adenocarcinoma, Yu Qian, Ana Galan-Cobo, Irene Guijarro, Minghao Dang, David Molkentine, Fahao Zhang, Jing Wang, Edwin Parra, Apekshya Panda, Jacy Fang, Ferdinandos Skoulidis, Ignacio I Wistuba, Svena Verma, Taha Merghoub, Jedd D Wolchok, Kwok-Kin Wong, Ralph J Deberardinis, John D Minna, Natalie I Vokes, Catherine B Meador, Justin F Gainor, Linghua Wang, Alexandre Reuben, John V Heymach

Faculty, Staff and Student Publications

Inactivating STK11/LKB1 mutations are genomic drivers of primary resistance to immunotherapy in KRAS-mutated lung adenocarcinoma (LUAD), although the underlying mechanisms remain unelucidated. We find that LKB1 loss results in enhanced lactate production and secretion via the MCT4 transporter. Single-cell RNA profiling of murine models indicates that LKB1-deficient tumors have increased M2 macrophage polarization and hypofunctional T cells, effects that could be recapitulated by the addition of exogenous lactate and abrogated by MCT4 knockdown or therapeutic blockade of the lactate receptor GPR81 expressed on immune cells. Furthermore, MCT4 knockout reverses the resistance to PD-1 blockade induced by LKB1 loss in syngeneic …


Real-Time Environmental Surveillance Of Sars-Cov-2 Aerosols, Joseph V Puthussery, Kevin R Mcbrearty, Brookelyn M Doherty, Woodrow D Gardiner, Jordan P Magrecki, Traci L Bricker, Adrianus C M Boon, Carla M Yuede, John R Cirrito, Et Al. Jul 2023

Real-Time Environmental Surveillance Of Sars-Cov-2 Aerosols, Joseph V Puthussery, Kevin R Mcbrearty, Brookelyn M Doherty, Woodrow D Gardiner, Jordan P Magrecki, Traci L Bricker, Adrianus C M Boon, Carla M Yuede, John R Cirrito, Et Al.

2020-Current year OA Pubs

Real-time surveillance of airborne SARS-CoV-2 virus is a technological gap that has eluded the scientific community since the beginning of the COVID-19 pandemic. Offline air sampling techniques for SARS-CoV-2 detection suffer from longer turnaround times and require skilled labor. Here, we present a proof-of-concept pathogen Air Quality (pAQ) monitor for real-time (5 min time resolution) direct detection of SARS-CoV-2 aerosols. The system synergistically integrates a high flow (~1000 lpm) wet cyclone air sampler and a nanobody-based ultrasensitive micro-immunoelectrode biosensor. The wet cyclone showed comparable or better virus sampling performance than commercially available samplers. Laboratory experiments demonstrate a device sensitivity of …