Digital Commons Network^™

Pharmaco-Proteogenomic Characterization Of Liver Cancer Organoids For Precision Oncology, Gaohua Wu, Yingcheng Wu, Youpei Lin, Dayun Lu, Yuanli Song, Peng Cui, Zijian Yang, Chen Sang, Guohe Song, Shangli Cai, Yuanchuang Li, Hanqing Lin, Shu Zhang, Xiaoying Wang, Shuangjian Qiu, Xiaoming Zhang, Guoqiang Hua, Junqiang Li, Jian Zhou, Zhi Dai, Xiangdong Wang, Li Ding, Pei Wang, Daming Gao, Bing Zhang, Henry Rodriguez, Jia Fan, Hans Clevers, Hu Zhou, Yidi Sun, Qiang Gao

Faculty, Staff and Students Publications

Organoid models have the potential to recapitulate the biological and pharmacotypic features of parental tumors. Nevertheless, integrative pharmaco-proteogenomics analysis for drug response features and biomarker investigation for precision therapy of patients with liver cancer are still lacking. We established a patient-derived liver cancer organoid biobank (LICOB) that comprehensively represents the histological and molecular characteristics of various liver cancer types as determined by multiomics profiling, including genomic, epigenomic, transcriptomic, and proteomic analysis. Proteogenomic profiling of LICOB identified proliferative and metabolic organoid subtypes linked to patient prognosis. High-throughput drug screening revealed distinct response patterns of each subtype that were associated with specific …

Surface-Doped Zinc Gallate Colloidal Nanoparticles Exhibit Ph-Dependent Radioluminescence With Enhancement In Acidic Media, Amar S Kumbhar, Jianguo Wen, Zhiping Luo

Faculty, Staff and Student Publications

As abnormal acidic pH symbolizes dysfunctions of cells, it is highly desirable to develop pH-sensitive luminescent materials for diagnosing disease and imaging-guided therapy using high-energy radiation. Herein, we explored near-infrared-emitting Cr-doped zinc gallate ZnGa2O4 nanoparticles (NPs) in colloidal solutions with different pH levels under X-ray excitation. Ultrasmall NPs were synthesized via a facile hydrothermal method by controlling the addition of ammonium hydroxide precursor and reaction time, and structural characterization revealed Cr dopants on the surface of NPs. The synthesized NPs exhibited different photoluminescence and radioluminescence mechanisms, confirming the surface distribution of activators. It was observed that the colloidal NPs emit …

Morphological And Electrical Variance In Polysilicon Thin Film Transistors Crystallized By Flash Lamp Annealing, Glenn Packard

Theses

This work is a wide-reaching study of the factors that impact the in-situ crystallization of thin films of amorphous silicon into low-temperature polycrystalline silicon (LTPS) by flash lamp annealing (FLA) on glass substrates, which is used to develop thin film transistors (TFTs) with an eye towards display applications. The body of research surrounding FLA LTPS is thus advanced by identifying several challenges towards industrial integration and exploring solutions involving device configuration, novel methods of dopant introduction and activation, and novel TFT material systems. It is unlikely that FLA will ever produce LTPS superior to the laser-annealing techniques currently dominating the …

Forensic Investigation Of Small-Scale Digital Devices: A Futuristic View, Farkhund Iqbal, Aasia Jaffri, Zainab Khalid, Aine Macdermott, Qazi Ejaz Ali, Patrick C. K. Hung

All Works

Small-scale digital devices like smartphones, smart toys, drones, gaming consoles, tablets, and other personal data assistants have now become ingrained constituents in our daily lives. These devices store massive amounts of data related to individual traits of users, their routine operations, medical histories, and financial information. At the same time, with continuously evolving technology, the diversity in operating systems, client storage localities, remote/cloud storages and backups, and encryption practices renders the forensic analysis task multi-faceted. This makes forensic investigators having to deal with an array of novel challenges. This study reviews the forensic frameworks and procedures used in investigating small-scale …

Comprehensive Analysis Of The Prognostic Significance Of The Trim Family In The Context Of Tp53 Mutations In Cancers, Trung Vu, Annaliese Fowler, Nami Mccarty

Faculty, Staff and Student Publications

The p53 protein is an important tumor suppressor, and TP53 mutations are frequently associated with poor prognosis in various cancers. Mutations in TP53 result in a loss of p53 function and enhanced expression of cell cycle genes, contributing to the development and progression of cancer. Meanwhile, several tripartite motif (TRIM) proteins are known to regulate cell growth and cell cycle transition. However, the prognostic values between TP53 and TRIM family genes in cancer are unknown. In this study, we analyzed the relationship between the

Emerging Therapies For Antibody-Mediated Rejection In Kidney Transplantation, Farah Abuazzam, Casey Dubrawka, Tarek Abdulhadi, Gwendolyn Amurao, Louai Alrata, Dema Yaseen Alsabbagh, Omar Alomar, Tarek Alhamad

2020-Current year OA Pubs

Despite the advances in immunosuppressive medications, antibody-mediated rejection (AMR) continues to be a major cause of kidney allograft failure and remains a barrier to improving long-term allograft survival. Recently, there have been significant advances in the understanding of the pathophysiological process of AMR, along with the development of new therapeutic options. Additionally, surveillance protocols with donor-derived cell-free DNA and gene profile testing have been established, leading to the early detection of AMR. A multitude of clinical trials are ongoing, opening numerous opportunities for improving outcome in kidney transplant recipients. In this brief review, we discuss the emerging therapies for managing …

Exfoliation And Spray Deposition Of Graphene Nanoplatelets In Ethyl Acetate And Acetone: Implications For Additive Manufacturing Of Low-Cost Electrodes And Heat Sinks, Muhammed Ramazan Oduncu, Zhifan Ke, Bingyuan Zhao, Zhongxia Shang, Robin Simpson, Haiyan Wang, Alexander Wei

Department of Chemistry Faculty Publications

Nonaqueous dispersions of graphene nanoplatelets (GrNPs) can be used to prepare thin films and coatings free of surfactants, but typically involve polar organic solvents with high boiling points and low exposure limits. Here, we describe the mechanochemical exfoliation and dispersion of GrNPs in volatile aprotic solvents such as ethyl acetate (EtOAc) and acetone, which rank favorably in green solvent selection guides. GrNPs in powder form were exfoliated with a solvent on a horizontal ball mill for 48 h and then sonicated at moderate power to produce suspensions in excess of 300 μg/mL with minimum loss of dispersion stability over 7 …

Babesa Sewage Treatment Plant As A Vital Artificial Wetland Habitat For A Multitude Of Avian Species, Pelden Nima, Mahendra Timsina, Tenzin Jamtsho, Pema Khandu

Research outputs 2022 to 2026

This study aimed to glean basic ecological aspects on diversity and abundance, temporal variation and guild composition of the birds at Babesa Sewage Treatment Plant (STP). The line transect method was used as the sampling technique from November 2021 to October 2022. A total of 80 species belonging to 58 genera, 29 families, and 11 orders were detected, of which three, namely, River Lapwing Vanellus duvaucelii, Falcated Duck Mareca falcata, and Ferruginous Duck Aythya nyroca, are ‘Near Threatened’ with the remaining being ‘Least Concern’. The highest species richness was recorded in the winter (6.29), the highest species diversity in the …

Predictive Modeling Of Cave Entrance Locations: Relationships Between Surface And Subsurface Morphology, William Blitch, Adia R. Sovie, Benjamin W. Tobin

International Journal of Speleology

Cave entrances directly connect the surface and subsurface geomorphology in karst landscapes. Understanding the spatial distribution of these features can help identify areas on the landscape that are critical to flow in the karst groundwater system. Sinkholes and springs are major locations of inflow and outflow from the groundwater system, respectively, however not all sinkholes and springs are equally connected to the main conduit system. Predicting where on the landscape zones of high connectivity exist is a challenge because cave entrances are difficult to detect and imperfectly documented. Wildlife research has a similar issue of understanding the complexities of where …

Eurozone: Central Bank Swap To Denmark, 2008, Salil Gupta

Journal of Financial Crises

Danish banks faced substantial losses on loans to the slowing construction sector in the run-up to the Global Financial Crisis (GFC) of 2007–09. The acceleration of the crisis in 2008 raised funding costs and froze foreign funding markets for Danish banks. The Danish central bank, the Danmarks Nationalbank (DN), responded by injecting liquidity and seeking to reassure bank counterparties about the soundness of the financial system. In October 2008, the DN established a swap agreement with the European Central Bank (ECB) under which it could receive up to EUR 12.0 billion (USD 16.8 billion) in exchange for Danish krone. The …

Bite-Sized Quantitative Reasoning Essays: A Review Of Numbers Don’T Lie: 71 Stories To Help Us Understand The Modern World (2020), By Vaclav Smil, Samuel L. Tunstall

Numeracy

In Numbers Don’t Lie: 71 Stories to Help Us Understand the Modern World (2020), Vaclav Smil draws on his interdisciplinary background in science, public policy, and history to provide readers with 71 short essays that help us better understand aspects of the world–including its people, environment, energy consumption, and present crises (among other things). In most of his essays, Smil utilizes both data and reasoning with data to shed light on diverse topics, with issues ranging from happiness rankings and vaccine payoffs to chicken production and diesel engines. Though the book arguably has some flaws, its easy-to-digest essays–many of which …

The Relationship Between Identity Styles And Conformity: Perspectives Of Students At Islamic Azad University – Shahr-E Rey Branch, Ameer Maadal, Salwa Al-Majali, Saba Nader Zadeh

An-Najah University Journal for Research - B (Humanities)

The present correlational, quantitative research aimed to examine the relationship between identity styles and conformity. To do so, a probability sample of 365 students were selected from Islamic Azad University – Shahr-e Rey Branch, Iran. among whom the conformity and identity styles questionnaires were distributed. The degrees of correlation between these two variables were determined by Pearson's bivariate correlation coefficient. The findings showed that there is a positive correlation between each of these identity styles and conformity. However, this relationship was only significant between the diffuse/avoidant identity style and conformity. The limitations and suggestions for further research are also mentioned …

Contexts Of Transformation And Integration In Palestinian Media Institutions In The Digital Age, Osama Abdallah, Ahmad Hamouda

An-Najah University Journal for Research - B (Humanities)

In this study, we sought to provide an accurate and detailed diagnosis of the transformations witnessed by Palestinian media institutions in light of the new environment of communication, and to know how Palestinian media institutions can establish a new communication model within their organizational structures in line with the new environment of communication in the digital age. It also discussed the mechanisms used by professional journalists in traditional Palestinian media institutions to deal with the contents produced by citizen journalists. In this context, we posed the following problem: What are the contexts of transformation and integration of traditional Palestinian media …

Fostering Human Dimension Of Smart Cities: Lessons From Jakarta For Nusantara, Indonesia’S New Capital City In The Making, Wicaksono Sarosa, Nurulitha Andini Susetyo, Marsa Nur Aulianisa, Mahbub Ridhoo Maulaa, Pradamas Giffary

Smart City

A city’s problems often arise as the population grows and urbanization happens. This process is linear to the development of information-and-communication technologies (ICT), especially in urban areas. As a result, cities have adopted an initiative to solve the problems which are popularly known as the smart city. Over decades, the idea of a smart city has evolved from a mere technological modernization to advanced utilization through community involvement. However, in practice, smart city ideas and initiatives often put a heavy emphasis on technical aspects and ignored the more human side, which has caused a digital divide. This paper argues that …

Cytochrome P450 Gene Families: Role In Plant Secondary Metabolites Production And Plant Defense, Panchali Chakraborty, Ashok Biswas, Susmita Dey, Tuli Bhattacharjee, Swapan Chakrabarty

Michigan Tech Publications

Cytochrome P450s (CYPs) are the most prominent family of enzymes involved in NADPH- and O2-dependent hydroxylation processes throughout all spheres of life. CYPs are crucial for the detoxification of xenobiotics in plants, insects, and other organisms. In addition to performing this function, CYPs serve as flexible catalysts and are essential for producing secondary metabolites, antioxidants, and phytohormones in higher plants. Numerous biotic and abiotic stresses frequently affect the growth and development of plants. They cause a dramatic decrease in crop yield and a deterioration in crop quality. Plants protect themselves against these stresses through different mechanisms, which are accomplished by …

Sarah Ehlen Receives Alumni Merit Award, Lindenwood University

Archived Lindenwood Press Releases

No abstract provided.

Using Machine Learning To Assist Auditory Processing Evaluation, Hasitha Wimalarathna, Sangamanatha Veeranna, Minh Vu Duong, Chris Allan Prof, Sumit K. Agrawal, Prudence Allen, Jagath Samarabandu, Hanif M. Ladak

Electrical and Computer Engineering Publications

Introduction: Approximately 0.2–5% of school-age children complain of listening difficulties in the absence of hearing loss. These children are often referred to an audiologist for an auditory processing disorder (APD) assessment. Adequate experience and training is necessary to arrive at an accurate diagnosis due to the heterogeneity of the disorder.

Objectives: The main goal of the study was to determine if machine learning (ML) can be used to analyze data from the APD clinical test battery to accurately categorize children with suspected APD into clinical sub-groups, similar to expert labels.

Methods: The study retrospectively collected data from 134 children referred …

Change Detection Of Open-Pit Mines Based On Fm-Unet++ And Gf-2 Satellite Images, Du Shouhang, Li Wei, Xing Jianghe, Zhang Chengye, She Changchao, Wang Shaoyu, Li Jun

Coal Geology & Exploration

Automatic extraction of land use change information in open-pit mines using the remote sensing and deep learning technology is of great significance for the mining monitoring and ecological environmental protection. A novel deep learning model FM-UNet++ was constructed for the change of land use types in complex and heterogeneous mining scenarios, and the automatic change detection of open-pit mines was achieved using the Gaofen-2 (GF-2) satellite images. Firstly, the change detection dataset of open-pit mine was produced through data surveys and visual interpretation, which was augmented by data enhancement. Secondly, the FM-UNet++ for open-pit mine change detection was constructed by …

Here Comes The Strain: Analyzing Defensive Pass Rush In American Football With Player Tracking Data, Quang Nguyen, Ronald Yurko, Gregory J. Matthews

Mathematics and Statistics: Faculty Publications and Other Works

In American football, a pass rush is an attempt by the defensive team to disrupt the offense and prevent the quarterback (QB) from completing a pass. Existing metrics for assessing pass rush performance are either discrete-time quantities or based on subjective judgment. Using player tracking data, we propose STRAIN, a novel metric for evaluating pass rushers in the National Football League (NFL) at the continuous-time within-play level. Inspired by the concept of strain rate in materials science, STRAIN is a simple and interpretable means for measuring defensive pressure in football. It is a directly-observed statistic as a function of two …

Modulating Water Distribution And The Intramicellar Assembly Of Sequence-Defined Ionic Peptoid Block Copolymers By The Ionic Monomer Position, Bailee N. Barrett, Chi Huan Tung, Guan Rong Huang, Istiak Hossain, Chang Woo Do, Vijay T. John, Wei Ren Chen, Donghui Zhang

Faculty Publications

The intramicellar mass heterogeneity of a series of sequence-defined ionic peptoid block copolymers carrying a single charged monomer has been determined through contrast variation small-angle neutron scattering analysis. We observe that the internal micellar structure, namely, the number density radial distributions of invasive water and peptoid polymer, is significantly impacted by the location of the ionic monomer. By positioning the ionic monomer progressively closer to the hydrophilic/hydrophobic block junction, the micelles become less compact with increasing levels of chain folding and invasive water to accommodate electrostatic repulsion among the ionic monomers via solvation. This results in increasingly smaller micellar aggregates …

Interiority And Agency: Exploring Self In Context With Others In The Act Of Creation, Barbara Young

Interiority

This investigation seeks to extend the discourse on interiority. I am an interior designer and, therefore, pose questions as they relate to design process, specifically that the concern regarding interiority is not necessarily something to design for, but as designers, it affects how and what we design. The presented cases are artistic explorations that provided an opportunity to interrogate interiority as it relates to my cognitive and creative process. Through an auto-ethnographic account, I present two acts of making. In the creation process, I interrogate meaning-making and perception that constitutes my subjective interiority, which can only be understood in context. …

Pillars Of Persistence: Factors That Influence Persistence Of First-Generation Students At 4-Year Public Institutions, Robert Stephen Wayland

Theses and Dissertations

In the past few decades, increased use of federal student loans has created an enormous financial burden for many first-generation and low-income students who attend 4-year public postsecondary institutions to attain a degree. Reaching those educational goals for many undergraduate students and how they reach their goals has been at the heart of much debate. The use of federal student loans and grants are paramount for many first-generation and low-income students in their pursuit of all benefits that accompany a postsecondary degree. There had been and will continue to be considerable consequences for the accumulation of debt through the use …

Underground Coal Gasification Field Tests In China: History And Prospects, Qin Yong, Yi Tongsheng, Yang Lei, Zhou Yongfeng, Wang Jun, Wang Lingxia

Coal Geology & Exploration

To achieve peak carbon dioxide emissions and carbon neutrality in China, a low-carbon and efficient coal energy structure is essential for the sustainable energy development of China. Underground coal gasification (UCG) is an important strategy for transforming the coal energy structure in China. Based on the review of previous literature, this study analyzes the exploration history of the UCG field tests in China and delivers the prospects of UCG industrialization in China. The analytical results show that the development and field tests of UCG technologies in China have experienced five stages, namely the initial attempt, silence/recovery, extensive explorations, making technological …

Construction And Engineering Applications Of Block Model For Coal Seam Value Considering The Variations In Coal Seam Thickness And Quality, Liu Feiyue, Yang Ke, Yang Tianhong, Kan Lei, Fu Kai

Coal Geology & Exploration

The variations in coal seam thickness and coal quality parameters (i.e., calorific value, volatile matter, ash content, and sulfur content) determine the spatial distribution of coal prices. The accurate characterization of coal seams’ economic value plays an important role in the rational mining and utilization of coal resources. This study first determined that the geological attributes of coal seams including their thickness and coal quality are regional variables. Based on this, this study discretized geological bodies in the study area using a block model. Then, using a geostatistical method, this study obtained the experimental semivariograms of coal seam thickness and …

Fluctuating Hydrodynamics And The Rayleigh–Plateau Instability, Bryn Barker, John B. Bell, Alejandro L. Garcia

Faculty Research, Scholarly, and Creative Activity

The Rayleigh–Plateau instability occurs when surface tension makes a fluid column become unstable to small perturbations. At nanometer scales, thermal fluctuations are comparable to interfacial energy densities. Consequently, at these scales, thermal fluctuations play a significant role in the dynamics of the instability. These microscopic effects have previously been investigated numerically using particle-based simulations, such as molecular dynamics (MD), and stochastic partial differential equation–based hydrodynamic models, such as stochastic lubrication theory. In this paper, we present an incompressible fluctuating hydrodynamics model with a diffuse-interface formulation for binary fluid mixtures designed for the study of stochastic interfacial phenomena. An efficient numerical …

Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 66 – West Ruby Dump, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 174 – Buffalo South And Bres No 174 – Buffalo Ditch, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Liposomes For The Treatment Of Brain Cancer—A Review, Richu Raju, Waad H. Abuwatfa, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release their payload controllably. Although research into liposomes for brain cancer treatment is still in its infancy, these systems have great potential to fundamentally change the drug delivery landscape. This review paper attempts to consolidate relevant literature regarding the delivery to the brain using nanocarriers, particularly liposomes. The paper first briefly explains conventional treatment modalities for cancer, followed …

Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 31 – Waste Dump #5, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Applicability Evaluation Technology Of Perforating Parameters In Different Reservoirs, Bi Gang, Wu Jiemin, Yang Shangyu, Li Mengmeng, Han Fei, Wang Xin, Cui Ying

Coal Geology & Exploration

Perforating parameters have an important impact on the productivity of oil and gas wells. Currently, the optimization of perforating parameters is mostly based on single factor analysis, with no multi-factor comprehensive evaluation analysis performed. In this paper, the finite element simulation method was used to analyze and study the influence law of perforating parameters on wellhead flow under different reservoir conditions. Firstly, a geometric model of pressure drop in reservoir with perforation completion was established to simulate the fluid flow after perforation. In this way, the influence laws of perforating parameters, anisotropy parameters and natural fracture parameters on the pressure …