Digital Commons Network^™

Myeloid Fth1 Deficiency Protects Mice From Colitis And Colitis-Associated Colorectal Cancer Via Reducing Dmt1-Imported Iron And Stat3 Activation, Zhaoli Liu, Mariella Arcos, David R. Martin, Xiang Xue

Pathology Research and Scholarship

BACKGROUND: Myeloid cells are critical for iron and immune homeostasis. Ferritin heavy chain (FTH1) is essential for intracellular iron storage. Myeloid FTH1 is important in the pathogenesis of many inflammatory diseases. However, the role of myeloid FTH1 in colitis and colitis-associated cancer has not been determined.

METHODS: Myeloid FTH1 deficient and wild-type mice were treated with dextran sodium sulfate (DSS) or azoxymethane (AOM)-DSS to compare their susceptibility to acute colitis or colitis-associated cancer.

RESULTS: Myeloid FTH1-deficient mice fed with a high-iron diet were less susceptible to DSS-induced acute colitis than wild type mice. Mechanistic studies showed that myeloid FTH1 deficiency …

Performance Evaluation Of E-Ticketing Technologies On Asphalt Paving Projects In New Mexico, Gena C. Robertson

Civil Engineering ETDs

The collection and processing of paper tickets for construction material delivery is an inefficient and antiquated practice that exposes inspectors on highway paving projects to substantial safety risks. An alternative to the collection of paper tickets is e-Ticketing, which uses web-based systems to deliver similar information. This research documented a current paper ticketing process and compared it to an e-Ticketing process that was implemented on several pilot projects. Data were obtained using stakeholder meetings, personnel interviews, and surveys. When compared to a paper ticketing system, e-Ticketing was shown to have fewer opportunities for error, require fewer decision points, and provide …

Development Of The Navigator: A Lagrangian Smart Sensing System To Characterize Aquatic Ecosystems., Aashish Sanjay Khandelwal

Civil Engineering ETDs

Most freshwater aquatic studies rely on Eulerian monitoring, i.e., water quality and quantity are monitored using grab samples or semi-continuous sensors deployed at fixed cross-sections. While Eulerian monitoring is practical, it provides a limited understanding of spatial and temporal heterogeneity and their effects on environmental processes. This dissertation summarizes the design and application of The Navigator, an alternative Lagrangian monitoring system that offers cost-effective solutions for in-situ, real-time data collection in lotic and lentic freshwater ecosystems such as streams, rivers, ponds, and reservoirs. The Navigator features a suite of methods – an autonomous surface vehicle (ASV) with GPS and LTE …

Synthetic Biology Enabled Modification Of Bone Cells And Impact On Bone Mineral Resorption, Dulce C. Hayes

Biomedical Sciences ETDs

Development of a cell culture based bone model can contribute to biomedical research by producing a reproducible model system that mimics a bone remodeling disorder and reduces the use of animals in research studies. Synthetic biology was used to engineer osteoblast cell lines to alter a key protein in the RANKL pathway in efforts to control the bone remodeling process. Osteoblast cell lines, K7M2 and MC3T3-E1 Subclone 4 were engineered to express osteoprotegerin (OPG) and inhibit OPG expression, respectively. The upregulation of OPG expression was confirmed with Real Time PCR and Quantikine® Immunoassay. To identify the functionality of the engineered …

Evolve Path Tracer: Early Detection Of Malicious Addresses In Cryptocurrency, Ling Cheng, Feida Zhu, Yong Wang, Ruicheng Liang, Huiwen Liu

Research Collection School Of Computing and Information Systems

With the boom of cryptocurrency and its concomitant financial risk concerns, detecting fraudulent behaviors and associated malicious addresses has been drawing significant research effort. Most existing studies, however, rely on the full history features or full-fledged address transaction networks, both of which are unavailable in the problem of early malicious address detection and therefore failing them for the task. To detect fraudulent behaviors of malicious addresses in the early stage, we present Evolve Path Tracer, which consists of Evolve Path Encoder LSTM, Evolve Path Graph GCN, and Hierarchical Survival Predictor. Specifically, in addition to the general address features, we propose …

The Future Of Cryptocurrency And Blockchain Technology In Finance, Wanyi Wong, Alan @ Ali Madjelisi Megargel

Research Collection School Of Computing and Information Systems

Cryptocurrencies have been all the rage in recent years, with many being drawn to their appeal as speculative investment assets. Its proponents also champion the secure and decentralised nature of the technology it is based on, called the blockchain. Given the secure nature of blockchain technology, the idea of adopting cryptocurrencies as legal tender currency has also been mooted and experimented with – with the most famous example being the Central American nation of El Salvador’s bold move to adopting the cryptocurrency Bitcoin as legal tender in September 2021. In theory, this would provide a solution to the high transaction …

Generalization Through Diversity: Improving Unsupervised Environment Design, Wenjun Li, Pradeep Varakantham, Dexun Li

Research Collection School Of Computing and Information Systems

Agent decision making using Reinforcement Learning (RL) heavily relies on either a model or simulator of the environment (e.g., moving in an 8x8 maze with three rooms, playing Chess on an 8x8 board). Due to this dependence, small changes in the environment (e.g., positions of obstacles in the maze, size of the board) can severely affect the effectiveness of the policy learned by the agent. To that end, existing work has proposed training RL agents on an adaptive curriculum of environments (generated automatically) to improve performance on out-of-distribution (OOD) test scenarios. Specifically, existing research has employed the potential for the …

Context-Aware Event Forecasting Via Graph Disentanglement, Yunshan Ma, Chenchen Ye, Zijian Wu, Xiang Wang, Yixin Cao, Tat-Seng Chua

Research Collection School Of Computing and Information Systems

Event forecasting has been a demanding and challenging task throughout the entire human history. It plays a pivotal role in crisis alarming and disaster prevention in various aspects of the whole society. The task of event forecasting aims to model the relational and temporal patterns based on historical events and makes forecasting to what will happen in the future. Most existing studies on event forecasting formulate it as a problem of link prediction on temporal event graphs. However, such pure structured formulation suffers from two main limitations: 1) most events fall into general and high-level types in the event ontology, …

Numgpt: Improving Numeracy Ability Of Generative Pre-Trained Models, Zhihua Jin, Xin Jiang, Xiangbo Wang, Qun Liu, Yong Wang, Xiaozhe Ren, Huamin Qu

Research Collection School Of Computing and Information Systems

Existing generative pre-trained language models (e.g., GPT) focus on modeling the language structure and semantics of general texts. However, those models do not consider the numerical properties of numbers and cannot perform robustly on numerical reasoning tasks (e.g., math word problems and measurement estimation). In this paper, we propose NumGPT, a generative pre-trained model that explicitly models the numerical properties of numbers in texts. Specifically, it leverages a prototype-based numeral embedding to encode the mantissa of the number and an individual embedding to encode the exponent of the number. A numeral-aware loss function is designed to integrate numerals into the …

A Computational Approach For The Discovery And Characterization Of Oligonucleotide Aptamers For Protein Targets, Godfred Sabbih

Masters Theses and Doctoral Dissertations

Aptamers are short polynucleotide chains that can bind with very high affinities to a broad range of chemical and biomolecular targets, including proteins, cells, viruses, microorganisms, toxins, and chemical compounds. They are analogous to antibodies with applications in therapeutic delivery, biosensors, and diagnostics, but possess the advantages of easy production and lower immunogenicity than antibodies. They are produced by the experimental method known as the systematic evolution of ligands by exponential enrichment (SELEX). SELEX is a powerful experimental method for selecting oligonucleotide aptamers for chemical or biomolecular targets of interest. The SELEX protocol has seen several modifications since its development …

A Computational Investigation Of Predicting Wind Tunnel Results For Selected Hypersonic Wing Test Structures, James Snuggs

Masters Theses and Doctoral Dissertations

A CFD methodology for simulating various configurations of three selected wings in Purdue University’s Boeing Air Force Office of Scientific Research Mach 6 Quiet Tunnel (BAM6QT) is presented. The NASA-developed computational fluid dynamics (CFD) code, FUN3D, is used to calculate forces, moments, and temperature gradients. Wings with an attached elevon are also simulated, and the large wing with elevon case is used to study a moving elevon as well as static elevon deflections. A threshold frequency is found for the moving elevon where the moment imparted by the elevon increases with frequency. An attempt is made to detect unsteadiness around …

The Impact Of Focused Advising On Retention And Completion In The Community College Setting, Peter O'Brien

Masters Theses and Doctoral Dissertations

The purpose of the study was to investigate and describe the impact of Focused Advising on retention and completion in the community college setting. This study examined one initiative known as Academic Foci or sometimes referred to as Guided Pathways as a viable tool for increasing the number of completers at an institution. The basis of the model was to place students into groups/foci of similar academic interests such as business, computer, or health sciences. With the aid of their advisor, the student made a move forward, and they will have made an informed decision about a chosen major. Once …

Secondary Teachers' Perceptions On Their Competency And Self-Efficacy Levels Associated With An Integrated Professional Development Approach To Teaching United States History, Darwin Anthony Galloway

Masters Theses and Doctoral Dissertations

The study assessed a multifaceted professional development approach and its impact on teacher competency and self-efficacy. The professional development approach considered in this study reflected an integration of Content Immersion Mini-institutes, Public History Field Experiences, and Collaborative Pedagogical workshops offered to middle school and high school United States history teachers. The major focus of the study was scaled exit surveys and free response questions completed by teachers in six school districts in northeastern Tennessee, who were part of a Teaching American History Grant program sponsored by Tennessee’s First Frontier Consortium. These extant exit surveys were used to determine the relationship …

Integrating Human Psychology Into Car-Following Models For Accurate Response Prediction: A Realistic Approach, Faiza Khan

Masters Theses and Doctoral Dissertations

Car-following models traditionally focus on vehicle kinematics or dynamics parameters without considering human psychology. However, recent research has attempted to incorporate psychology into car-following models. Despite these efforts, there are limitations in understanding the psychological triggers that influence individual drivers' responses. To address this gap, we propose a new car-following model based on the Theory of Planned Behavior (TPB), which incorporates a human element by utilizing concepts of psychology. To gather the data pertaining to human input a questionnaire was carefully developed utilizing the Theory of Planned Behavior. Data collection and analysis were done through a survey using google forms. …

Towards Intelligent Runtime Framework For Distributed Heterogeneous Systems, Polykarpos Thomadakis

Computer Science Theses & Dissertations

Scientific applications strive for increased memory and computing performance, requiring massive amounts of data and time to produce results. Applications utilize large-scale, parallel computing platforms with advanced architectures to accommodate their needs. However, developing performance-portable applications for modern, heterogeneous platforms requires lots of effort and expertise in both the application and systems domains. This is more relevant for unstructured applications whose workflow is not statically predictable due to their heavily data-dependent nature. One possible solution for this problem is the introduction of an intelligent Domain-Specific Language (iDSL) that transparently helps to maintain correctness, hides the idiosyncrasies of lowlevel hardware, and …

Near- And Far- Field Optical Response Of Ensembles Of Nanostructures, Lauren Zundel

Physics & Astronomy ETDs

The ability of metallic nanostructures to support collective oscillations of their conduction electrons, known as surface plasmons, makes them attractive candidates for a wide range of applications in areas as diverse as cancer therapy, biosensing, and solar energy harvesting. These applications are especially promising for periodic arrays of nanostructures, which can support collective modes known as lattice resonances, and for nanostructures with extreme aspect ratios that give rise to enhanced light-matter interaction. In this Thesis, we employ a coupled dipole model to theoretically explore the lattice resonances supported by complex arrays of nanoparticles containing multiple nanoparticles per unit cell. We …

High-Power Laser Cooling And Temperature-Dependent Fluorescence Studies Of Ytterbium Doped Silica, Brian Topper

Optical Science and Engineering ETDs

Experimental observation of optical refrigeration using ytterbium doped silica glass in recent years has created a new solution for heat mitigation in high-power laser systems, nonlinear fiber experiments, integrated photonics, and precision metrology. Current efforts of different groups focus on compositional optimization, fiber fabrication, and investigating how much silica can be cooled with a laser. At the start of this work, the best effort in laser cooling ytterbium doped silica saw cooling by 6 K from room temperature. This dissertation follows the experimental efforts that culminated in the increase of this initial record by one order of magnitude. Comprehensive spectroscopic …

Super-Resolution Microscopy With Color Centers In Diamond, Forrest A. Hubert

Optical Science and Engineering ETDs

This dissertation explores the development and application of diamond color centers, specifically the silicon-vacancy (SiV) and nitrogen-vacancy (NV) centers, in super-resolution microscopy and magnetic imaging techniques. It demonstrates the potential of SiV centers as photostable fluorophores in stimulated emission depletion (STED) microscopy, with a resolution of approximately 90 nm. The research also presents a method for nanoscale magnetic microscopy using NV centers by combining charge state depletion (CSD) microscopy with optically detected magnetic resonance (ODMR) to image magnetic fields produced by 30 nm iron-oxide nanoparticles. The individual magnetic feature width reaches ~100 nm while resolving magnetic field patterns from nanoparticles …

Seismic Analysis Of The Upper & Lower Falls Of The Yellowstone River, Loring Schaible

Earth and Planetary Sciences ETDs

Twelve years of concurrent hydrologic and continuous seismic data along with temporary seismic data demonstrate that the Upper and Lower Falls of the Grand Canyon of the Yellowstone River comprise a highly localized source of 0.5-5 Hz seismic energy that overwhelms anthropogenic contributions. In aggregate, seismic amplitude from 2008-2019 is linearly related to discharge with a correlation coefficient of 0.96. Repeated deviations from this linear relationship persist for 1-2 weeks prior to the date that Yellowstone Lake becomes clear of winter ice coverage. Seismic efficiency increases by ~50-250% during this period of ice-breakup, during which lake ice flows into the …

Hydrothermal Liquefaction Of Wastewater Sludges For Energy Resource Recovery, Carl L. Abadam

Civil Engineering ETDs

This study aims to identify how variabilities in wastewater process configurations impact the biocrude yields from sludges processed and stabilized by hydrothermal liquefaction. Clean and renewable energy sources are vital to ensure a sustainable future. However, the current consumption of fossil fuels limits the ability to achieve this goal. Hydrothermal liquefaction (HTL) is a thermochemical process that converts wet biomass to valuable biocrude oil and biochar while reducing solid masses. Wastewater sludges were sampled across three facilities with varying influent design capacities and biological treatment configurations. Lipids extracted via solvent extraction and biocrudes produced from HTL were determined gravimetrically. Relative …

Role Of Endophytic Fungi On Arsenic Uptake In Solution: Insights For Bioremediation, Taylor Lillian Busch

Civil Engineering ETDs

Hazardous metals mobilized from natural deposits and mining legacy are environmental and human health concerns. The waters of our partner Native American communities affected by uranium and gold mining legacy exceed the EPA MCL of 10 µg/L arsenic (As). Bioremediation is a novel technology that uses native resources to remediate metals in the soil and groundwater. Plant-fungi symbiosis for bioremediation is widely studied, but the role of endophytic fungi in metal uptake is not well understood. The objectives of this study are to 1) determine As uptake by symbiotic endophyte Cadophora sp. and little bluestem grass (Schizachyrium scoparium) …

Identifying The Required Ecological Flow For Sediment Movement In The Río Chama: Field Data Informed Visual Spatial Model, Cristian Kremer

Civil Engineering ETDs

The continuous alteration of flow regimes in rivers has led to negative impacts on habitats and biotic communities, causing irreversible effects on river biodiversity. Implementing e-flows in management strategies can repair historical mismanagement, prevent further degradation, and restore ecosystem services. In the case of the Rio Chama, damming has altered its hydrological regime, affecting sediment transport. Experts recommend specific e-flow conditions for the Rio Chama to improve ecological conditions, in particular a bankfull discharge of 70 m³s^-1 every 2 years for sediment flushing and channel maintenance. The Río Gallina, a tributary of the Rio Chama, plays a …

Combining Semi-Continuous And Discrete Water Quality Data To Characterize Solute Transport, Biogeochemical Processes, And Wildfire Disturbances In Fluvial Systems, Justin Rae Nichols

Civil Engineering ETDs

In the past decade, high-frequency water quality sondes have become more abundant in watersheds across North America and Europe and are gaining a foothold in Asia and South America. In this dissertation, three relevant topics associated with high-frequency data are investigated, i.e., the impact of winter’s precipitation on surface water quality and stream metabolism, the longitudinal propagation of wildfire disturbances through a fluvial network, and the use of machine learning with high-frequency data to estimate fluvial nutrient processing. First, we found that significant snow precipitation can cause surface water anoxia and declines in stream metabolism. Second, our data illustrate that …

Towards Sustainable Water Management: Soil Analysis, Modeling, And Sensor Implementation On A Micro-Basin Chile's Los Lagos Region, Tammy N. Huynh

Civil Engineering ETDs

The Los Lagos region of Chile is experiencing ecological and socioeconomic challenges because of climate change. Despite efforts by the agricultural sector to understand and manage water resources, the lack of basic water quantification data affects their ability to effectively plan and implement water management strategies. This research aims to address this critical issue through three key objectives. First, characterize soil properties related to texture and structure in a micro-basin of the Los Lagos region. Secondly, it aims to investigate the hydrologic budget of the micro-basin with an emphasis on soil moisture using the Soil Moisture Routing model (SMR). Lastly, …

News Media Framing Of Disabilities In Ghana: Journalistic Practices Amidst Advocacy Calls For Change, Pamela Ofori Boateng

Communication ETDs

The study contributes to expanding scholarly research on media portrayals of people with disabilities in Ghana. Drawing on theories of framing, ableism, and intersectionality, I analyzed news stories published in Graphic.com.gh. in 2021 and 2022 to explore how the editorial practices framed people with disabilities and how framing patterns revealed change and continuity in representation. The findings affirmed a shift to using more diverse and appropriate language to represent people with disabilities more fairly and accurately; the categorization of most of the disability stories under “General News,” which suggests the significance attached to disability related stories; and the …

A Comparison Of Fixed Versus Moving Eulerian Meshes For 1-D Radiative Shock Problems, Dylan Weatherred

Nuclear Engineering ETDs

Testing codes used to solve the radiation-hydrodynamics equations requires the use of radiative shock problems. These problems contain stiff shocks and test the coupling of the material motion and the energy exchange between the radiation and material. However, these problems are difficult to solve due to large differences in time scale between radiation and material equations, resolving shocks, and modeling radiation and material interactions. This thesis will look to solve radiative shock problems in 1-D using the Eulerian formulation on fixed and moving meshes. The moving mesh method proposed takes advantage of the more simple Eulerian formulation of the radiation …

Miniature, Submersible Electromagnetic Pumps Of Molten Lead And Sodium For Gen-Iv Nuclear Reactors Development, Ragai M. Altamimi

Nuclear Engineering ETDs

Heavy metals and alkali Liquid Metals are suitable coolants for Generation IV terrestrial nuclear reactors for operating at elevated temperatures for achieving plant thermal efficiency more than 40% and the thermochemical generation of hydrogen fuel. In addition, the low vapor pressure of these liquids eliminates the need for a pressure vessel and instead operates slightly below ambient pressure. A primary issue with the uses of these coolants is their compatibility with nuclear fuel, cladding and core structure materials at elevated temperatures more than 500oC. Therefore, in pile and out-of-pile test loops have been constructed or being considered for quantifying the …

Big Data Policing Capacity Measurement, Ronald J. Coleman

New Mexico Law Review

Big data, algorithms, and computing technologies are revolutionizing policing. Cell phone data. Transportation data. Purchasing data. Social media and internet data. Facial recognition and biometric data. Use of these and other forms of data to investigate, and even predict, criminal activity is law enforcement’s presumptive future. Indeed, law enforcement in several major cities have already begun to develop a big data policing mindset, and new forms of data have played a central role in high-profile matters featured in the Serial and To Live and Die in LA podcasts, as well as in the Supreme Court’s leading privacy and criminal procedure …

Virtual Learning Environments And Digital Twins: Enhancing Accessibility, Diversity, And Flexibility In Training Secondary Educational Administrators, James Hutson, Robert Steffes, Joe Weber

Faculty Scholarship

This study investigates the potential of Virtual Learning Environments (VLEs) and digital twins to overcome geo-graphical, scheduling, and diversity barriers in the training of secondary educational administrators. Recognizing the limitations in traditional in-person visits to schools-particularly for graduate students in rural areas and those working fulltime with dependents-and the current ethnic composition of educational administrators, where White individuals comprise 64.5% of the population in the US (71.01% for principals), this research explores how VLEs can democratize access and foster diversity in educational leadership training. Over the academic year 2022–2023, pre- and post-engagement surveys were administered to students in a Visionary …

Military Women In World Cinema: A 20th Century History And Filmography, Introduction, Deborah A. Deacon, Stacy Fowler

Faculty Articles

From British soldier Flora Sandes to the fame World War II Night Witches of the Soviet Air Force, women across the globe stepped up to defend their countries during every major and minor conflict of the twentieth century, and filmmakers have long attempted to capture their stories.

This book analyzes real and fictional military women's portrayals in world cinema, including movies from Israel, the United Kingdom, Italy, China, France, the Soviet Union, and others. It includes theatrical releases, direct-to-video productions, and made-for-television films.

Chapters, organized by decade, address topics including the women's sexuality, maternal and marital status, leadership skills, actual …