Digital Commons Network^™

Hydraulic Habitat Suitability For The Rio Grande Silvery Minnow At The Los Chavez Irrigation Outfall, New Mexico, Haley A. Ormsbee

Civil Engineering ETDs

It is essential to manage the Middle Rio Grande for aquatic species to preserve the native biodiversity of the river. During periods of low flow, endangered species such as the Rio Grande Silvery Minnow (RGSM) may get trapped in a drying reach without the ability to escape from isolated pools. Very little is known about how areas of refuge, such as irrigational outfall channels, buffer RGSM from stream flow intermittency. Hence, there is a crucial need to quantify available habitat for RGSM in areas of refuge. This study aims to make connections between flow regimes and physical-habitat conditions to help …

A Comparison Of Different Stomatal Density Phenotypes Of Hordeum Vulgare Under Varied Watering Regimes Reveals Superior Genotypes With Enhanced Drought Tolerance, Brittany Clare Robertson, Yong Han, Chengdao Li

Grain and Other Field Crops Research Articles

Enhancing the water-use efficiency (WUE) of barley cultivars may safeguard yield deficits during periods of low rainfall. Reduced stomatal density is linked to enhanced WUE, leading to improved drought resistance across plant genera. In this study, 10 barley varieties exhibiting a range of stomatal density phenotypes were grown under differing soil water contents to determine whether stomatal density influences the capacity of genotypes to resist low water availability. The low-stomatal-density genotype Hindmarsh showed the least impact on biomass production during early development, with a 37.13% decrease in dry biomass during drought treatment. Low-stomatal-density genotypes additionally outcompeted high-stomatal-density genotypes under water-deprivation …

Model-Free Sliding Mode Control In The Lateral And Direction Dynamics Of An Aircraft, Nicholas Hutson

Theses

Traditional control methods require extensive tuning or a derivation of a system model making them increasingly antiquated for use on new, more complex systems. Sliding Mode Control has emerged as a more effective alternative as a control method that can directly handle nonlinear systems with increased robustness while guaranteeing stability. However, it is still limited by the need for a system model for the derivation of the controller form. This work proposes a new model-free control method based on Sliding Mode Control referred to as Model-Free Sliding Mode Control where the form of the controller is only dependent on system …

A Search Of M31 For Giant Radio Pulses From Radio Pulsars And Magnetars, David Saroff

Theses

We present results of a 40-hour survey of the nearby galaxy M31 for giant radio pulses (GRPs) from radio pulsars using the Green Bank Radio telescope (GBT) in the 300 MHz to 400 MHz band. We note that GRPs from known pulsars in the Milky Way or its nearest companion galaxies, the Magellanic clouds, if relocated to M31, would not be detectable with the GBT in the 300 MHz to 400 MHz band. However, the brightest GRPs from a pulsar in M31, like the Crab pulsar B0531+21, are within a factor of 2 of detectability. Our observations cover a projected …

Dust Reverberation Mapping Of Active Galactic Nuclei: Effects Of Survey Duration And Sampling, Shaelyn Shadwell

Theses

In the next few years, large-scale surveys with a time domain element, such as the ten-year Legacy Survey of Space and Time (LSST), will produce an immense data set to study variable and transient astronomical sources such as active galactic nuclei (AGN). AGN are located at the center of most galaxies and have five major components: a supermassive black hole (SMBH), an accretion disk, the broad-line region (BLR), a dusty circumnuclear torus, and the narrow-line region (NLR). The torus is believed to have a two-component structure: a geometrically thin circumnuclear disk and a hollow dusty cone along the polar axis. …

Using Natural Language Processing To Support Software Security Requirement Development, Spencer Herzog

Theses

The advent of Natural Language Processing (NLP) tools has had profound effects upon the software requirements engineering process. Engineering requirements are a key part of software development, guiding the overall process and ensuring that the resulting software can properly accomplish the desired results without any issues. NLP tools have been used alongside requirements engineering for many years, in a variety of tasks. Our study investigates the uses of NLP tools, including OpenAI's large language model (LLM) tool ChatGPT as well as a novel Natural Language Inference (NLI) model that our team proposed, for the use of classification of various software …

Noise-Resilient And Adaptive Distributed Control Techniques For Microgrids, Seyed Iman Habibi

Electrical and Computer Engineering ETDs

This dissertation focuses on addressing the critical tasks of secondary control in microgrids, particularly in the islanding operating mode. The presence of noise in sensors and communication links necessitates the design of a noise-resilient secondary control approach. In response, this dissertation introduces the Nonlinear Generalized Minimum Variance (NGMV) control approach into the islanded AC and DC microgrid's secondary control system. The effectiveness of the proposed approach is demonstrated through MATLAB simulations. Additionally, the dissertation presents an adaptive, model-free, and data-driven control approach for secondary voltage control in AC microgrids, addressing uncertainties. By employing Unfalsified Adaptive Control (UAC), the approach selects …

Neuroaffirmative Approaches To Extended Reality: Empowering Individuals With Autism Spectrum Condition Through Immersive Learning Environments, James Hutson, Caitlyn Mcginley

Faculty Scholarship

Traditional teaching and working environments often prioritize extroverted qualities, disadvantaging individuals with conditions that impact social engagement, such as autism spectrum condition (ASC). These individuals usually thrive in calmer, low-key learning environments but face challenges in lecture-style classes, and traditional office environments leading to marginalization in academic and professional settings. This study explores the neuroaffirming potential of extended reality (XR) in creating immersive learning and working environments tailored to the unique needs of individuals with ASC. By focusing on four key factors—indirect social engagement, digital communication preferences, sensory sensitivity, and avatar-based communication—XR technologies can provide a supportive and accommodating environment …

A Data-Light And Trajectory-Based Machine Learning Approach For The Online Prediction Of Flight Time Of Arrival, Zhe Zheng, Bo Zou, Wenbin Wei, Wen Tian

Faculty Research, Scholarly, and Creative Activity

The ability to accurately predict flight time of arrival in real time during a flight is critical to the efficiency and reliability of aviation system operations. This paper proposes a data-light and trajectory-based machine learning approach for the online prediction of estimated time of arrival at terminal airspace boundary (ETA_TAB) and estimated landing time (ELDT), while a flight is airborne. Rather than requiring a large volume of data on aircraft aerodynamics, en-route weather, and traffic, this approach uses only flight trajectory information on latitude, longitude, and speed. The approach consists of four modules: (a) reconstructing the sequence of trajectory points …

A Review For Green Energy Machine Learning And Ai Services, Yukta Mehta, Rui Xu, Benjamin Lim, Jane Wu, Jerry Gao

Faculty Research, Scholarly, and Creative Activity

There is a growing demand for Green AI (Artificial Intelligence) technologies in the market and society, as it emerges as a promising technology. Green AI technologies are used to create sustainable solutions and reduce the environmental impact of AI. This paper focuses on describing the services of Green AI and the challenges associated with it at the community level. This article also highlights the accuracy levels of machine learning algorithms for various time periods. The process of choosing the appropriate input parameters for weather, locations, and complexity is outlined in this paper to examine the ML algorithms. For correcting the …

Vol 68 #4, Melanie Argo

MPLA Newsletter

No abstract provided.

Gamma Secretase Activating Protein Promotes End-Organ Dysfunction After Bacterial Pneumonia, Meredith S. Gwin, Mikhail F. Alexeyev, Aron M. Geurts, Ji Young Lee, Chun Zhou, Xi-Ming Yang, Michael V. Cohen, James M. Downey, Robert A. Barrington, Domenico Spadafora, Jonathon P. Audia, Dara W. Frank, Sarah Voth, Viktoriya V. Pastukh, Jessica Bell, Linn Ayers, Dhananjay T. Tambe, Amy R. Nelson, Ron Balczon, Mike T. Lin, Troy Stevens

University Faculty and Staff Publications

Pneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) link- ing infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the hypothesis that gamma-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dys- function following bacterial pneumonia. First-in-kind Gsap knockout rats were generated. Wild-type and knockout rats possessed simi- lar body weights, organ weights, circulating blood cell counts, arterial blood gases, and cardiac indices at baseline. Intratracheal Pseudomonas aeruginosa infection caused acute lung injury and a hyperdynamic circulatory state. …

Gamma Secretase Activating Protein Promotes End-Organ Dysfunction After Bacterial Pneumonia, Meredith S. Gwin, Mikhail F. Alexeyev, Aron M. Geurts, Ji Young Lee, Chun Zhou, Xi-Ming Yang, Michael V. Cohen, James M. Downey, Robert A. Barrington, Domenico Spadafora, Jonathon P. Audia, Dara W. Frank, Sarah Voth, Viktoriya V. Pastukh, Jessica Bell, Linn Ayers, Dhananjay T. Tambe, Amy R. Nelson, Ron Balczon, Mike T. Lin, Troy Stevens

University Faculty and Staff Publications

Pneumonia elicits the production of cytotoxic beta amyloid (Aβ) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Aβ is unknown. Here, we tested the hypothesis that gamma-secretase activating protein (GSAP), which contributes to the amyloidogenic pathway in the brain, promotes end-organ dysfunction following bacterial pneumonia. First-in-kind Gsap knockout rats were generated. Wild-type and knockout rats possessed similar body weights, organ weights, circulating blood cell counts, arterial blood gases, and cardiac indices at baseline. Intratracheal Pseudomonas aeruginosa infection caused acute lung injury and a hyperdynamic circulatory state. Whereas infection led …

The Relationship Between Colorado Teacher Salary And Colorado Teacher Turnover, Jason Lee Seybert

Dissertations

This secondary research study used quantitative research methods to gather and analyze statistical data on specific factors that have been demonstrated to impact teacher retention and assessed their relative importance in impacting teacher turnover. The data utilized for this study were peer-reviewed, publicly available, government data collected by the Colorado Department of Education. The time period examined in this study was the school years of 2015-2019. The study found teacher salary was a significant determinant of teacher retention in Colorado. When controlling for other potentially important factors, such as academic performance, English language learners, socioeconomic status, minority students, and setting …

Experiences Of Middle School Students With Visual Impairments Accessing Technologies In Inclusive Classrooms, Anitha Muthukumaran

Dissertations

As the educational environment is moving more towards a technology-rich system, students with visual impairments (VI) educated in general education classrooms must be guaranteed equitable access to content curricula. The purpose of this study was to understand the experiences of middle school students with VI when accessing and using technologies in general education classrooms. In this multiple case study, three middle school students with VI were observed in general education settings for two school days. In addition to the students, general education teachers and teachers of students with VI (TVI) also participated in the study to understand how best they …

A Bayesian Approach To Unit Lindley Mixed Model, Nirajan Bam

Dissertations

In the applied filed of many areas such as Business and Economics, Physical, Biological, Medical, Environmental, and Social Sciences, Psychology, and Educations outcome measurements like rates, proportions, and fractions are common. Researchers have proven that using normal linear regression to analyze the relationship between outcome measurements such as rates and proportions and a set of independent variables can violates key assumptions of the method. Transformation techniques are usually applied to correct the assumptions, but this practice can violate the probability property of bounded nature of outcome variables. Even though beta regression was one of the popular methods to analyze bounded …

Co-Targeting Nucleus Accumbens Associate 1 And Nf-Κb Signaling Synergistically Inhibits Melanoma Growth, Lixiang Gu, Xingcong Ren, Chrispus Ngule, Xiaofang Xiong, Jianxun Song, Zhiguo Li, Jin-Ming Yang

Markey Cancer Center Faculty Publications

Nucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the NACC1 gene, which is amplified and overexpressed in various human cancers and has been appreciated as one of the top potential cancer driver genes. NAC1 has therefore been explored as a potential therapeutic target for managing malignant tumors. Here, we show that NAC1 is a negative regulator of NF-κB signaling, and NAC1 depletion enhances the level of the nuclear NF-κB in human melanoma. Furthermore, the inhibition of NF-κB signaling significantly potentiates the antineoplastic activity of the NAC1 inhibition in both the cultured melanoma cells and xenograft tumors. This study …

Identification Of Immunodominant T Cell Epitopes Induced By Natural Zika Virus Infection, Christopher S. Eickhoff, Krystal A. Meza, Frances E. Terry, Chase G. Colbert, Azra Blazevic, Andres H. Gutiérrez, E. Taylor Stone, James D. Brien, Amelia K. Pinto, Hana M. El Sahly, Mark J. Mulligan, Nadine Rouphael, Maria L. Alcaide, Kay M. Tomashek, Chris Focht, William D. Martin, Leonard Moise, Anne S. De Groot, Daniel F. Hoft

Markey Cancer Center Faculty Publications

Zika virus (ZIKV) is a flavivirus primarily transmitted by Aedes species mosquitoes, first discovered in Africa in 1947, that disseminated through Southeast Asia and the Pacific Islands in the 2000s. The first ZIKV infections in the Americas were identified in 2014, and infections exploded through populations in Brazil and other countries in 2015/16. ZIKV infection during pregnancy can cause severe brain and eye defects in offspring, and infection in adults has been associated with higher risks of Guillain-Barré syndrome. We initiated a study to describe the natural history of Zika (the disease) and the immune response to infection, for which …

Metabolic Disruption Induced By Mtor Signaling Pathway Inhibition In Regulatory T-Cell Expansion For Clinical Application, Roberto Gedaly, Gabriel Orozco, Alexandre P. Ancheta, Mackenzie Donoho, Siddharth Desai, Fanny Chapelin, Aman Khurana, Lillie J. Lewis, Cuiping Zhang, Francesc Marti

Markey Cancer Center Faculty Publications

Background: Regulatory T cell (Treg) therapy is considered an alternative approach to induce tolerance in transplantation. If successful, this therapy may have implications on immunosuppression minimization/withdrawal to reduce drug-induced toxicity in patients. The aim of this study was to assess the efficacy of the mTORC1/C2 inhibitor, AZD8055, in the manufacturing of clinically competent Treg cells and compare the effects with those induced by rapamycin (RAPA), another mTOR inhibitor commonly used in Treg expansion protocols.

Methods: Primary human Treg cells were isolated from leukapheresis product. Cell viability, expansion rates, suppressive function, autophagy, mitochondrial unfolded protein response (mitoUPR), and cell metabolic profile …

Phosphatase And Pseudo-Phosphatase Functions Of Phosphatase Of Regenerating Liver 3 (Prl-3) Are Insensitive To Divalent Metals In Vitro, Jeffery T. Jolly, Ty C. Cheatham, Jessica S. Blackburn

Markey Cancer Center Faculty Publications

Phosphatase of regenerating liver 3 (PRL-3) is associated with cancer metastasis and has been shown to interact with the cyclin and CBS domain divalent metal cation transport mediator (CNNM) family of proteins to regulate the intracellular concentration of magnesium and other divalent metals. Despite PRL-3’s importance in cancer, factors that regulate PRL-3’s phosphatase activity and its interactions with CNNM proteins remain unknown. Here, we show that divalent metal ions, including magnesium, calcium, and manganese, have no impact on PRL-3’s structure, stability, phosphatase activity, or CNNM binding capacity, indicating that PRL-3 does not act as a metal sensor, despite its interaction …

Portable Optical Spectroscopic Assay For Non-Destructive Measurement Of Key Metabolic Parameters On In Vitro Cancer Cells And Organotypic Fresh Tumor Slices, Jing Yan, Carlos Frederico Lima Goncalves, Madison O. Korfhage, Zahid Hasan, Teresa Whei-Mei Fan, Xiaoqin Wang, Caigang Zhu

Markey Cancer Center Faculty Publications

To enable non-destructive metabolic characterizations on in vitro cancer cells and organotypic tumor models for therapeutic studies in an easy-to-access way, we report a highly portable optical spectroscopic assay for simultaneous measurement of glucose uptake and mitochondrial function on various cancer models with high sensitivity. Well-established breast cancer cell lines (MCF-7 and MDA-MB-231) were used to validate the optical spectroscopic assay for metabolic characterizations, while fresh tumor samples harvested from both animals and human cancer patients were used to test the feasibility of our optical metabolic assay for non-destructive measurement of key metabolic parameters on organotypic tumor slices. Our optical …

Structures Of The Insecticidal Toxin Complex Subunit Xpta2 Highlight Roles For Flexible Domains, Cole L. Martin, David W. Chester, Christopher D. Radka, Lurong Pan, Zhengrong Yang, Rachel C. Hart, Elad M. Binshtein, Zhao Wang, Lisa Nagy, Lawrence J. Delucas, Stephen G. Aller

Markey Cancer Center Faculty Publications

The Toxin Complex (Tc) superfamily consists of toxin translocases that contribute to the targeting, delivery, and cytotoxicity of certain pathogenic Gram-negative bacteria. Membrane receptor targeting is driven by the A-subunit (TcA), which comprises IgG-like receptor binding domains (RBDs) at the surface. To better understand XptA2, an insect specific TcA secreted by the symbiont X. nematophilus from the intestine of entomopathogenic nematodes, we determined structures by X-ray crystallography and cryo-EM. Contrary to a previous report, XptA2 is pentameric. RBD-B exhibits an indentation from crystal packing that indicates loose association with the shell and a hotspot for possible receptor binding or a …

Prairie Protector: Student Development Of Systems Thinking Habits In The Context Of Agroecosystems, Erin Ingram, Jennifer Keshwani

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Introduction: The Great Plains ecosystem offers an opportunity for young people to gain knowledge about intricate systems through practical learning. The spread of woody plants into grasslands, known as the “Green Glacier,” poses a risk to biodiversity and animal production. Although effective management strategies exist, some land managers are reluctant to use them. It is critical to cultivate a scientifically literate population that can think systematically and make informed decisions based on STEM principles to address such complex agroecosystem problems.

Methods: In this study, semi-structured focus group discussions with high school students were analyzed to determine whether Prairie …

Cross-Cutting Skills: The Role Of Major, Maureen Snow Andrade, Eugene Seeley, Ron Miller

International Journal for Business Education

Employers want recent college graduates prepared with skills that cut across majors, such as written and oral communication, teamwork, ethical decision-making, critical thinking, and applying knowledge in real-life situations. What is largely unknown is if some fields of study lend themselves to producing these desired skills over others. This is particularly relevant to schools of business, which strive to help students develop professional career skills and often emphasize a range of practical, hands-on, engaged learning activities. This study focused on obtaining the insights of hiring managers about desired skills and areas of study that prepare students with these skills. Survey …

Low Internal Air Space In Plants With Crassulacean Acid Metabolism May Be An Anatomical Spandrel, Alistair Leverett, Anne Borland, Emma Inge, Samantha Hartzell

Civil and Environmental Engineering Faculty Publications and Presentations

Crassulacean Acid Metabolism (CAM) is a photosynthetic adaptation found in at least 38 plant families. Typically, the anatomy of CAM plants is characterised by large photosynthetic cells and a low percentage of leaf volume comprised of internal air space (% IAS). It has been suggested that reduced mesophyll conductance (g_m) arising from low % IAS benefits CAM plants by preventing the movement of CO₂ out of cells and ultimately minimising leakage of CO₂ from leaves into the atmosphere during day-time decarboxylation. Here, we propose that low % IAS does not provide any adaptive benefit to …

Theoretical And Experimental Study Of Active Magnetic Bearing Control Integrated On Bently's Rotor Kit, Arturo Mario Flores

Master's Theses

This thesis focuses on the comprehensive study of controlling a customized Active Magnetic Bearing (AMB) installed on Bently Nevada’s RK4 rotor kit in Cal Poly’s Vibrations and Rotordynamics Lab. The AMB was uniquely designed and manufactured by a Cal Poly senior project team to fit Bently’s rotor kit and the results of this research are distinctive to the custom system. To achieve practical functionality of the AMB system, we designed a controller a Virtual Instrument (VI) using the National Instrument software, LabVIEW. From the experimental study, we calibrated the programming to find unknown parameters of the AMB system and validated …

Web Based Management System For Housing Society, Likhitha Reddy Eddala

Electronic Theses, Projects, and Dissertations

Web Based Management System for Housing Society plays a major role in our day-to-day life. We develop a global web dependent application using AngularJS, Node JS and MySQL, with Xampp as the server to make an effective management system. This system is designed to provide a user-friendly and efficient platform for managing all the details of daily notices, monthly meetings, events, payments, maids etc., This system mainly consists of three modules, they are: Admin, User and Security. Each module here serves specific features and functionalities present within society. Admin module provides the features for managing user, houses, security, maids, notices, …

Subject-Specific Human Knee Fea Models For Transtibial Amputees Vs Control Tibial Cartilage Pressure In Gait, Cycling And Elliptical Training, Ali Yazdkhasti

Master's Theses

Millions of individuals around the globe are impacted by osteoarthritis, which is the prevailing type of arthritis. This condition arises as a result of gradual deterioration of the protective cartilage that safeguards the ends of the bones. This is especially true of transtibial amputees, who have a significantly higher incidence of osteoarthritis of the knee in their intact limb than non-amputees. Engaging in regular physical activity, managing weight effectively, and undergoing specific treatments can potentially slow down the advancement of the disease and enhance pain relief and joint function. Nevertheless, the relationship between the type of exercise and its impact …

A Case For Educational Communication On Sustainable Stormwater Management Sites Using Interpretive Methods: Applications For Utah State University, Lilian Taft

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Humans are increasingly urbanizing landscapes, lowering the land’s ability to infiltrate stormwater, increasing surface water runoff. This, combined with decreasing water availability in the Intermountain West, produces the issue of sustainable stormwater management. Professionals are moving toward green stormwater infrastructure (GSI), but public is often not aware of stormwater’s impacts on natural environments or what the purpose of GSI is. Stormwater management design techniques are evolving to use visible, sustainable methods celebrating stormwater, rather than treating the valuable resource as a disposable nuisance, channeling it underground and out of sight. Artful Rainwater Design (ARD), a technique coined by Stuart Echols …

An Evaluation Of Waste And Well Water Quality For Agriculture Production Around Erbil City, Iraq, Abdulqader M. Youni, Dlshad A. Darwesh

Baghdad Science Journal

Erbil city is located in the northern Iraq with a population of over one million people. Due to water crises farmers usually use wastewater and well water for the agricultural production. In this study six stations were designed to sample waste water and three from well water to define waste water and ground water characteristics. In this study, Residual Na+ Carbonate, Mg++ hazard, salinity hazard, Kelley index, %sodium, total hardness, permeability index, potential salinity, sodium adsorption ratio, and Irrigation Water Quality Index (IWQI) were determined. The order of average cation concentrations in water was Mg2+> Ca2+ > Na+ > K+. While the …