Digital Commons Network^™

Vegf-B Prevents Excessive Angiogenesis By Inhibiting Fgf2/Fgfr1 Pathway, Chunsik Lee, David M Ornitz, Et Al.

2020-Current year OA Pubs

Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases. It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms. Using comprehensive in vitro and in vivo methods and models, we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting …

Exome-Based New Allele-Specific Pcr Markers And Transferability For Sodicity Tolerance In Bread Wheat (Triticum Aestivum L.), Roopali Bhoite, Rosemary Smith, Urmil Bansal, Mirza Dowla, Harbans Bariana, Darshan L. Sharma

Grain and Other Field Crops Research Articles

Targeted exome-based genotype by sequencing (t-GBS), a sequencing technology that tags SNPs and haplotypes in gene-rich regions was used in previous genome-wide association studies (GWAS) for sodicity tolerance in bread wheat. Thirty-nine novel SNPs including 18 haplotypes for yield and yield-components were identified. The present study aimed at developing SNP-derived markers by precisely locating new SNPs on ~180 bp allelic sequence of t-GBS, marker validation, and SNP functional characterization based on its exonic location. We identified unknown locations of significant SNPs/haplotypes by aligning allelic sequences on to IWGSC RefSeqv1.0 on respective chromosomes. Eighteen out of the target 39 SNP locations …

A Thesis On The Human Genetic Basis Of Severe Pneumococcal Infection In Papua New Guinea, Emma Catherine Walker

Arts & Sciences Graduate Student Theses and Dissertations

Pneumonia remains a major cause of childhood mortality, especially in under-resourced communities. The profound morbidity of pediatric pneumonia in Papua New Guinea (PNG) compels innovative approaches to ameliorate disease. While the high incidence of pneumonia has been ascribed to environmental factors, we here identify a heritable allele increasing risk of severe pneumonia. In a pilot study, whole exome sequencing reveals a single nucleotide variant (SNV) in coenzyme Q6 (COQ6), a mitochondrial enzyme essential for ubiquinone biosynthesis. Significant association of SNV homozygosity with pneumonia replicates in an independently recruited cohort (p=0.036). Mice homozygous for the murine variant exhibit increased mortality after …

Advances In The Radiological Evaluation Of And Theranostics For Glioblastoma, Grayson W Hooper, Shehbaz Ansari, Jason M Johnson, Daniel T Ginat

Faculty, Staff and Student Publications

Imaging is essential for evaluating patients with glioblastoma. Traditionally a multimodality undertaking, CT, including CT cerebral blood profusion, PET/CT with traditional fluorine-18 fluorodeoxyglucose (18F-FDG), and MRI have been the mainstays for diagnosis and post-therapeutic assessment. However, recent advances in these modalities, in league with the emerging fields of radiomics and theranostics, may prove helpful in improving diagnostic accuracy and treating the disease.

Comparative Proteomic Analysis Of Exosomes Derived From Endothelial Cells And Schwann Cells, Lei Wang, Xuerong Lu, Michael Chopp, Chao Li, Yi Zhang, Alexandra Szalad, Xian Shuang Liu, Zhenggang Zhang

Neurology Articles

Exosomes derived from endothelial cells and Schwann cells have been employed as novel treatments of neurological diseases, including peripheral neuropathy. Exosomal cargo plays a critical role in mediating recipient cell function. In this study, we thus performed a comprehensive proteomic analysis of exosomes derived from healthy mouse dermal microvascular endothelial cells (EC-Exo) and healthy mouse Schwann cells (SC-Exo). We detected 1,817and 1,579 proteins in EC-Exo and SC-Exo, respectively. Among them, 1506 proteins were present in both EC-Exo and SC-Exo, while 311 and 73 proteins were detected only in EC-Exo and SC-Exo, respectively. Bioinformatic analysis revealed that EC-Exo enriched proteins were …

Don't Fear The Artificial Intelligence: A Systematic Review Of Machine Learning For Prostate Cancer Detection In Pathology, Aaryn Frewing, Alexander B. Gibson, Richard Robertson, Paul Urie, Dennis Della Corte

Faculty Publications

The adoption of whole slide image (WSI) scanners in clinical practice was accelerated by US Food and Drug Administration approval in 2017, which allowed primary pathologic diagnoses to be made on scanned images. Images in the digital domain allow the application of pathology artificial intelligence (AI), including clinical decision support with algorithms performing specific diagnoses.1,2 These algorithms, if trained properly, could go beyond the ability of human observation to detect and quantify features that are not recognizable by human perception.1,3,4

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

Dean Of Engineering Joins Farms Board

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Douglas M. Chabries, professor of Electrical and Computer Engineering and Dean of the College of Engineering and Technology at BYU, has accepted an invitation to become a member of the board of directors of FARMS. He brings to the board some new research perspectives and a wealth of university administrative experience.

Preliminary Study Identifies Possible Sources For Nephi's Ore

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

The efforts begun by Warren and Michaela Aston to identify important sites along the Lehi trail eventually evolved into a FARMS project and exploration to Southern Oman's Dhofar region in 1992. The remote area of Wadi Sayq in that region has been identified as a location that appears to meet all of the criteria one can infer from the text of the Book of Mormon for the coastal site named Bountiful by Lehi and his family, where they lived while building a ship for their ocean crossing.

The Legacy Of The Builder: Joseph T. Jones And The Development Of Gulfport, Mississippi, Reagan Grimsley

Journal of Mississippi History

No abstract provided.

Otto Karl Wiesenburg: A Racial Moderate Who Helped Crack The Walls Of The Mississippi "Closed Society", Charles M. Dollar

Journal of Mississippi History

No abstract provided.

National Education Policy 2020 And Changing Role Of Libraries, Yashwant S. Chaudhari Mr.

Library Philosophy and Practice (e-journal)

The present paper attempts to determine the National education policy 2020 and the role of libraries and information centers. However, these prospects have not been revealed clearly in NEP. However, libraries with quality collections of digital resources must communicate quality education. According to NEP 2020, several educational levels will be introduced, including fundamental education, preparatory education, middle education, secondary education, under-graduation, post-graduation education stage, Research Stage, and Lifelong learning stage. NEP has emphasized the significance of libraries in a number of areas, including the preservation of national heritage and the promotion of reading culture. Additionally, through practicing fixed librarianship, library …

Does Loyalty Program Membership Lead To Repeat Purchase: A Demographic Analysis With Customer Profiling And Machine Learning, Reeti Agarwal

Management Dynamics

Background: The current study was undertaken to find out the various benefits customers perceive as accruing from being members of loyalty programs of departmental stores. The study outspreads Yi and Jeon’s (2003) work assimilated along with the diverse advantages framework advocated by Mimouni-Chaabane and Volle (2010) from the perspective of departmental stores in India. Objective: The primary aim of the current study is to find out different groups of customers based on their perception of loyalty program benefits and to identify their demographic profile. Material and methods: The scale relating to observed loyalty program benefits was authenticated in respect of …

A New Planning Proposal For Achieving Residents’ Thermal Comfort In Hot Arid Climate- Based On Simulation Model, Mohamed A. Eid, Randa M. A. Mahmoud, Amr Sayed Hassan Abdallah

Mansoura Engineering Journal

This paper aims to propose a new planning approach that achieves residents' thermal comfort inside the courtyards of residential complexes based on the improvement of the urban canyon ratio in the current residential complex in New Assiut city as a base case, including their role in boosting social interaction and improving residents’ Outdoor thermal comfort (OTC) and courtyard air quality. This new planning proposal is based on the planning of old Arab cities that encourages liveability, walkability, social interaction, and sustainability. Then, improvement of urban canyon ratios for the new planning proposal was simulated and optimized using ENVI-met 5. Eight …

A Nonstandard Finite Difference Numerical Solution For The Equal-Width Wave Equation, H. A. Elagamy, Z. F. Abushaeer, Galal I. El-Baghdady

Mansoura Engineering Journal

This study aims to develop an unconditionally stable numerical scheme for the equalwidth wave equation. An unconventional finite difference discretization is employed to accomplish this. The John von Neumann methodology is used to examine the stability of the suggested method, and the suggested scheme's precision is established. Numerical results with comparisons are shown to demonstrate the viability of the suggested approach for the equal-width wave equation.

Integrated Water Quality Assessment In Damietta Branch Intakes At Dakahlia Governorate, Egypt, M. Elbagoury, H. Omara, Bakenaz A. Zeidan

Mansoura Engineering Journal

The water quality of the Damietta branch evaluated and assessed using the water quality index (WQI), including twenty-one physical, chemical, and biological parameters (Temperature, Turbidity, Chlorine, Electrical Conductivity, Total Dissolved Solids, pH, Chloride, Total Alkalinity, Total Hardness, Dissolved Oxygen, Chemical Oxygen Demand, Biological Oxygen Demand, Nitrogen, Sulfate, Calcium, Total phosphorus, Sodium, Potassium, Nitrate, Magnesium, and Total Coliform) measured at eleven different drinking water intake stations in Dakahlia governorate along the Damietta branch of the Nile river for four successive years from 2018 to 2021. The scale for evaluating the water quality of the Damietta branch of the Nile River is …

Exact/Partial Cipher-Text Retrieval On The Encrypted Cloud Database Using Sckha Algorithm, Samia Souror, Mohammed Badawy, Nawal El-Fishawy

Mansoura Engineering Journal

Searchable encryption techniques are intelligent tools that attempt to solve the challenge of querying stored data on untrusted cloud servers while preserving data confidentiality. This paper proposes simple, powerful, and practical Searchable Symmetric Encryption (SSE) scheme which capable of executing SQL (Structural Query Language) queries over encrypted cloud databases. Our scheme improves the efficiency of the search over encrypted data by using the SCKHA (Symmetric Cipher based on Key Hashing Algorithm) algorithm instead of using the bloom filter technique which causes the problem of the false positives. We built a complicated index structure for the encrypted data by combining the …

Medical School Watercooler Newsletter - August 17, 2023, Lindsey Lyle

Watercooler Newsletter

This is the August 17, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• USA SRFC receives grant to support' Food as Medicine initiative
• Basic medical sciences graduate student receives esteemed Gilliam fellowship
• All of Us research program seeks participants
• USA mourns loss of Cindy sheets, M.D.. retires pediatrics faculty member
• Register now: CME opportunities for opioids and ethics credits

Effects Of Digestion, Cell Culture Media, And Mucous On The Physical Properties, Cellular Effects, And Translocation Of Polystyrene And Polymethacrylate Nanoparticles, Zainab Jabor, Steev Sutton

Pharmacy Student Publications

The discovery of plastic and metal nanoparticles in organisms, foods, and beverages has generated numerous studies on the effects of these particles on the barrier cells and their subsequent absorption into the body. Following ingestion, nanoparticles travel down the gastrointestinal tract (GIT), and their physicochemical characteristics change in response to the change in proteins and pH during their digestion. We measured the translocation of digested nanoparticles across a co-culture monolayer of Caco-2 and various combinations (1:9, 5:5, and 9:1) of HT29-MTX-E12. The in vitro model of the intestine was used to determine the translocation of digested 20 nm polymethacrylate (PMA) …

The Indiana Statesman, Move In Guide 2023, Indiana State University

Student Newspaper

Move In Guide 2023

Particle Drift Potential Of Mesotrione And Rimsulfuron Plus Thifensulfuron-Methyl Tank Mixture In A Low-Speed Wind Tunnel, Milan Brankov, Guilherme Sousa Alves, Bruno Canella Vieira, Milos Zaric, Greg R. Kruger

West Central Research and Extension Center, North Platte

Particle drift happens during herbicide application when droplets travel outside the intended site. Different nozzles produce various range of droplets, so they play a very important role in coverage and drift occasions. When nozzles produce small droplets, the potential for off-target movement is very high. Another important factor determining particle drift is the distance between crops. Wind velocity gives the energy to herbicide particles to move away from the target place. Therefore, a drift simulation of herbicide (mesotrione and rimsulfuron plus thifensulfuron-methyl mixture) was done in a wind tunnel, using different nozzles Extended Range (XR) and Turbo TeeJet Induction (TTI). …

Katanning Research Station Showcase: Projects And Initiatives, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock research reports

An overview of current projects run from Katanning Research Station.

Katanning Research Station is a sheep, pasture and cropping research hub. The digital agriculture technologies and management systems are designed to lift productivity and lower greenhouse gas emissions. The research includes the:

• genetics (breeding values) of feed intake efficiency in sheep
• impact of feed supplements and forage combinations on methane production of sheep
• evaluation of novel pasture species to develop livestock systems of green feed year round
• saltland rehabilitation program that aims to halt and reverse salinity (surface water management and groundwater drainage), and provide out-of-season feed (the planting of …

Contractors State License Board, Lindsay Thompson, Katie Gonzalez

California Regulatory Law Reporter

No abstract provided.

Public Utilities Commission, Shiloh Wallack, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.

Spatiotemporal Dynamics Of The Marine Invertebrate Community Associated With Amathia Verticillata, Emily Masini Zavacki, Nathalie Reyns Phd, Michel Boudrias Phd, Jeff Crooks Phd

Theses

Non-indigenous species (NIS) are often thought to have negative consequences on ecosystems. However, some NIS are ecosystem engineers, organisms that modify and/or create habitats by changing physical structure (either biogenic or abiotic), such as Amathia verticillata (previously Zoobotryon verticillatum [delle Chiaje, 1822]), a non-indigenous bryozoan with a global distribution. The role of NIS as ecosystem engineers can be complicated due to the mix of impacts that they may have on the ecosystem. Thus, the role of A. verticillata as an ecosystem engineer may shift our understanding about its ecological role on anthropogenic structures, such as docks through an urbanized area, …

Trust, Distrust And Control Interplay In Interorganizational Relations, Agnieszka Padzik-Wołos, Anna Pikos, Dominika Latusek

European Management Studies

Purpose: The purpose of this paper is to provide a systematic literature review of research on the interplay between trust, distrust and control in interorganizational relations. The authors aim at diagnosing the current state of research along with gaps in the literature and then outlining opportunities for further research. The paper fulfills the aims by exploring the literature in four fields: (1) the understanding of trust, distrust and control, (2) interplay between trust and control, (3) relation between control and distrust and (4) relation between trust, distrust and control. Design/methodology/approach: The systematic literature review was conducted following the framework in …

The Minutes Of The Marshall University Staff Council Meeting, August 2023, Marshall University Staff Council

Staff Council Minutes

No abstract provided.

Researchers Find Walkable Communities Are Healthier For Both Mom And Baby, Robbin Ray

Media Relations

No abstract provided.

Preparing For V2x Deployment: Evaluating Current Anonymity Implementations, And Developing A Framework For Gauging Roadside Unit Networkability, Daniel Arnaudov Sharp

Theses and Dissertations

In this thesis we answer two questions relating to the impending deployment of V2X. We answer, "What is the state of current privacy measures implemented to prevent tracking and promote anonymity?" We answer this by showing that tracking methods used to circumvent changing IDs are possible. We also show through conservative calculations that this problem will not go away on its own and requires direct effort. We also answer, "Is the available production V2X hardware ready for scalable deployment?" To do this we develop a framework for evaluating RSUs and many of their core functions related to deployment, scalability, and …

Designed For Better Control: Using Kinematic And Dynamic Metrics To Optimize Robot Manipulator Design, John R. Morrell

Theses and Dissertations

In the field of control theory, optimal performance is generally defined as the best possible controlled performance given a static, unchangeable plant system. However, principled design of the underlying system can make designing effective controllers easier and dramatically improve the final control performance beyond what any finely tuned controller could achieve alone. This work develops performance metrics for serial robot arms which help guide the design and optimization of the structure of the arm to achieve greater final performance. First, a kinematic (motion-based) metric called the Actuator Independence Metric (AIM) measures the uniqueness of the movement capabilities of the different …