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Optimization Of Light Spectrum During Coral Grow-Out, Daisy N. Ponce Aug 2023

Optimization Of Light Spectrum During Coral Grow-Out, Daisy N. Ponce

All HCAS Student Capstones, Theses, and Dissertations

Direct and indirect anthropogenic stressors have led to a global decline of coral populations. Coral restoration aims to mitigate this loss and facilitate reef recovery. In particular, the sexual propagation of corals ex situ allows for the production and outplant of genetically diverse coral recruits on the reef. However, optimization at ex situ coral nurseries is required to scale-up production. This project aims to investigate and develop methods that reduce the duration of grow-out ex situ by determining the optimal light spectrum under which to rear for sexual recruits of the tropical scleractinian coral species Pseudodiploria strigosa and P. …


A Critical Inter-Subunit Interaction For The Transmission Of The Allosteric Signal In The Agrobacterium Tumefaciens Adp-Glucose Pyrophosphorylase, Hiral Patel, Gabriela Martinez-Ramirez Ms., Emily Dobrzynski, Alberto A. Iglesias, Dali Liu, Miguel Ballicora Aug 2023

A Critical Inter-Subunit Interaction For The Transmission Of The Allosteric Signal In The Agrobacterium Tumefaciens Adp-Glucose Pyrophosphorylase, Hiral Patel, Gabriela Martinez-Ramirez Ms., Emily Dobrzynski, Alberto A. Iglesias, Dali Liu, Miguel Ballicora

Chemistry: Faculty Publications and Other Works

ADP-glucose pyrophosphorylase is a key regulatory enzyme involved in starch and glycogen synthesis in plants and bacteria, respectively. It has been hypothesized that inter-subunit communications are important for the allosteric effect in this enzyme. However, no specific interactions have been identified as part of the regulatory signal. The enzyme from Agrobacterium tumefaciens is a homotetramer allosterically regulated by fructose 6-phosphate and pyruvate. Three pairs of distinct subunit-subunit interfaces are present. Here we focus on an interface that features two symmetrical interactions between Arg11 and Asp141 from one subunit with residues Asp141 and Arg11 of the neighbor subunit, respectively. Previously, scanning …


Regulation Of Stress Responses And Membrane Morphology By Dspa In Synechocystis Sp. Pcc 6803, Rebekah Kathryn White Aug 2023

Regulation Of Stress Responses And Membrane Morphology By Dspa In Synechocystis Sp. Pcc 6803, Rebekah Kathryn White

Theses and Dissertations

In the world of microorganisms, cyanobacteria are a uniquely skilled powerhouse. They participate in global nutrient and carbon cycling. They have the ability to photosynthesize, which allows them to use sunlight and carbon dioxide to produce cellular energy. However, photosynthesis has a lot of points were environmental stresses can interfere, increasing the chances of oxidative stress and nutrient imbalances that can amplify deleterious effects. One regulator in particular will be the target of this study. DspA, also known as Hik33, is a histidine kinase that perceives and regulates multiple overlapping stress responses. In this project, abiotic stress effects will be …


August 8, 2023 Ereporter, University Of Alabama At Birmingham Aug 2023

August 8, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Supporting The “Virtuous Cycle” In Urban Ecosystems: How Research Can Inform Plans, Policies, And Projects That Impact Urban Resilience, Michele Romilini, Sophie S. Parker, Gregory B. Pauly, Eric M. Wood Aug 2023

Supporting The “Virtuous Cycle” In Urban Ecosystems: How Research Can Inform Plans, Policies, And Projects That Impact Urban Resilience, Michele Romilini, Sophie S. Parker, Gregory B. Pauly, Eric M. Wood

Center for Urban Resilience Scholarship

No abstract provided.


Final Approved Request For Change Bg-2023-01 To Final Bpsou Hydrocarbon Sampling And Treatability Study Quality Assurance Project Plan (Qapp), Josh Bryson Aug 2023

Final Approved Request For Change Bg-2023-01 To Final Bpsou Hydrocarbon Sampling And Treatability Study Quality Assurance Project Plan (Qapp), Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Improving Peripheral Nerve Regeneration Through Rehabilitation And Biomaterial-Based Drug Delivery Strategies, Yunfan Kong Aug 2023

Improving Peripheral Nerve Regeneration Through Rehabilitation And Biomaterial-Based Drug Delivery Strategies, Yunfan Kong

Theses & Dissertations

Peripheral nerve injury (PNI) is a common problem worldwide, with trauma being a common cause. PNI can lead to loss of sensory and motor functions, chronic neuropathic pain, and mental health issues, significantly impacting patients' family life, work, and social situation. Recent studies revealed that beyond the topical injury site at peripheral nerves, PNIs can also induce dysfunctions in the central nervous system (CNS) by causing maladaptive plasticity, which will result in exaggeration and exacerbation of the pathological condition caused by primary injuries. The common therapy strategies for PNI treatment are using sutures, nerve autografts or conduits in cases requiring …


Genteel Culture, Legal Education, And Constitutional Controversy In Early Virginia, Matthew J. Steilen Aug 2023

Genteel Culture, Legal Education, And Constitutional Controversy In Early Virginia, Matthew J. Steilen

Journal Articles

This article focuses on the movement to reform legal education in early national Virginia, offering a fresh perspective by examining the connection between legal education and society and culture. It challenges the notion that constitutional ideas were the primary driving force behind reforms and argues that social status and “manners” played a more significant role. Wealthy elites in Virginia associated manners with education, sending their sons to college to become gentlemen, as it secured their aspirations to gentility and their influence over society and politics. Reformers sought to capitalize on this connection by educating a generation of university-trained, genteel lawyers …


Crop Monitoring And Nutrient Prediction Using Satellite Imagery And Soil Data, Olatunde D. Akanbi, Brian Gonzalez Hernandez, Erika I. Barcelos, Arafath Nihar, Laura S. Bruckman, Yinghui Wu, Jeffrey Yarus, Roger H. French Aug 2023

Crop Monitoring And Nutrient Prediction Using Satellite Imagery And Soil Data, Olatunde D. Akanbi, Brian Gonzalez Hernandez, Erika I. Barcelos, Arafath Nihar, Laura S. Bruckman, Yinghui Wu, Jeffrey Yarus, Roger H. French

Student Scholarship

No abstract provided.


Molecular Mechanisms Of Snorna-Ll-15 Crosstalk In Adipocyte Lipolysis And Nk Cell Rejuvenation, Yaohua Zhang, Zilong Zhao, Lisa A Huang, Yuan Liu, Jun Yao, Chengcao Sun, Yajuan Li, Zhao Zhang, Youqiong Ye, Fei Yuan, Tina K Nguyen, Nikhil Reddy Garlapati, Andrew Wu, Sergey D Egranov, Abigail S Caudle, Aysegul A Sahin, Bora Lim, Laura Beretta, George A Calin, Dihua Yu, Mien-Chie Hung, Michael A Curran, Katayoun Rezvani, Boyi Gan, Zhi Tan, Leng Han, Chunru Lin, Liuqing Yang Aug 2023

Molecular Mechanisms Of Snorna-Ll-15 Crosstalk In Adipocyte Lipolysis And Nk Cell Rejuvenation, Yaohua Zhang, Zilong Zhao, Lisa A Huang, Yuan Liu, Jun Yao, Chengcao Sun, Yajuan Li, Zhao Zhang, Youqiong Ye, Fei Yuan, Tina K Nguyen, Nikhil Reddy Garlapati, Andrew Wu, Sergey D Egranov, Abigail S Caudle, Aysegul A Sahin, Bora Lim, Laura Beretta, George A Calin, Dihua Yu, Mien-Chie Hung, Michael A Curran, Katayoun Rezvani, Boyi Gan, Zhi Tan, Leng Han, Chunru Lin, Liuqing Yang

Faculty, Staff and Student Publications

Obesity, in which the functional importance of small nucleolar RNAs (snoRNAs) remains elusive, correlates with risk for many cancer types. Here, we identify that the serum copies of adipocyte-expressed SNORD46 correlate with body mass index (BMI), and serum SNORD46 antagonizes interleukin-15 (IL-15) signaling. Mechanically, SNORD46 binds IL-15 via G11, and G11A (a mutation that significantly enhances binding affinity) knockin drives obesity in mice. Functionally, SNORD46 blocks IL-15-induced, FER kinase-dependent phosphorylation of platelet glycoprotein 4 (CD36) and monoglyceride lipase (MGLL) in adipocytes, leading to inhibited lipolysis and browning. In natural killer (NK) cells, SNORD46 suppresses the IL-15-dependent autophagy, leading to reduced …


Ten Questions Concerning Smart And Healthy Built Environments For Older Adults, Sanjay Kumar, Samuel H. Underwood, Julie L. Masters, Natalie A. Manley, Iason Konstantzos, Josephine Lau, Ryan Haller, Lily M. Wang Aug 2023

Ten Questions Concerning Smart And Healthy Built Environments For Older Adults, Sanjay Kumar, Samuel H. Underwood, Julie L. Masters, Natalie A. Manley, Iason Konstantzos, Josephine Lau, Ryan Haller, Lily M. Wang

Durham School of Architectural Engineering and Construction: Faculty Publications

In the past decade, the term ‘global aging’ has gained much attention among researchers, policymakers, civil societies, and governments worldwide. The continuous decline in fertility rates and increased life expectancy have resulted in an ongoing demographic transition where the share of adults aged 65 or older is increasing and outnumbering children younger than five years. In the United States and other developed countries, this rapid demographic transition is expected to continue to strain the existing health infrastructure as it becomes increasingly challenging to ensure healthy living environments for older adults. The ten questions and answers in this paper have been …


Gambaran Kejadian Computer Vision Syndrome Dan Faktor Risikonya Pada Mahasiswa Fkm Ui Di Masa Pandemi Covid-19, Rahadian Muhamad Shadik, Baiduri Widanarko Aug 2023

Gambaran Kejadian Computer Vision Syndrome Dan Faktor Risikonya Pada Mahasiswa Fkm Ui Di Masa Pandemi Covid-19, Rahadian Muhamad Shadik, Baiduri Widanarko

National Journal of Occupational Health and Safety

Due to the Covid-19 pandemic, many activities that were previously carried out offline have turned into online, including the education sector. This condition increased the use duration of electronic devices with digital screens/VDT, especially among students. It is one of the risk factors for Computer Vision Syndrome. Apart from duration, several risk factors are also associated with Computer Vision Syndrome. The aims of this study are to see an overview of Computer Vision Syndrome incidence and analyze the relationship between Computer Vision Syndrome incidence and its risk factors in regular (S1) and postgraduate (S2) students, FKM UI during the Covid-19 …


Synthesis Of Sustainable Polyethylene Mimics Through Ring-Opening Metathesis Polymerization, Brandon Zhang Aug 2023

Synthesis Of Sustainable Polyethylene Mimics Through Ring-Opening Metathesis Polymerization, Brandon Zhang

Theses

Polyethylene is the most produced plastic in the world due to its versatility and ubiquitous applications. The production and use of polyethylene however pose sustainability issues such as using petroleum resources and the persistence of its waste in landfills and oceans. Though not every issue can be addressed simultaneously, the more critical issue is to develop a polyethylene that can degrade within a few months instead of hundreds of years. A possible solution is to synthesize a polyethylene mimic, consisting of long chain of methylene groups with an occasional input of a functional group while maintaining similar properties as that …


Effects Of High School Engineering Course Availability And Participation On Engineering School Recruitment, Discipline Selection, Persistence Attitudes, And Self-Efficacy, Kristin S. Sandberg Aug 2023

Effects Of High School Engineering Course Availability And Participation On Engineering School Recruitment, Discipline Selection, Persistence Attitudes, And Self-Efficacy, Kristin S. Sandberg

Theses and Dissertations

The need for engineers in the workforce continues to grow. Filling this need requires recruiting future engineers to colleges and universities and retaining them through to degree completion. However, this is easier said than done. Universities are tasked with attempting to keep up with the demand for new engineers and companies are searching for new engineers to recruit. One avenue that has been established in the attempt to reach students for engineering is offering engineering or STEM classes in K-12 schools.

This dissertation looked at engineering classes offered at the high school level. These courses were analyzed for relationships with …


Script-Based Design Toolkit For Digitally Fabricated Concrete Applied To Terrain-Responsive Retaining Wall Design, Nada Abdel-Aziz Aug 2023

Script-Based Design Toolkit For Digitally Fabricated Concrete Applied To Terrain-Responsive Retaining Wall Design, Nada Abdel-Aziz

Theses and Dissertations

The potential of digitally fabricated concrete (DFC) to produce terrain responsive designs has not been thoroughly investigated. Existing research indicates diverse benefits of DFC, such as the rapid fabrication of customized geometries. This research clarifies the advantages and design processes involved in creating site-specific DFC structures. Existing literature is analyzed to provide an overview of fabrication methods and their impacts and constraints on design. Parametric scripting is used to develop an interactive toolkit that integrates aesthetic, structural, and fabrication considerations into the design process. This toolkit specifically focuses on unreinforced retaining walls with interchangeable modules for terrain analysis, wall form …


Resource Optimization Of Edge Servers Dealing With Priority-Based Workloads By Utilizing Service Level Objective-Aware Virtual Rebalancing, Amna Shahid Aug 2023

Resource Optimization Of Edge Servers Dealing With Priority-Based Workloads By Utilizing Service Level Objective-Aware Virtual Rebalancing, Amna Shahid

Theses and Dissertations

IoT enables profitable communication between sensor/actuator devices and the cloud. Slow network causing Edge data to lack Cloud analytics hinders real-time analytics adoption. VRebalance solves priority-based workload performance for stream processing at the Edge. BO is used in VRebalance to prioritize workloads and find optimal resource configurations for efficient resource management. Apache Storm platform was used with RIoTBench IoT benchmark tool for real-time stream processing. Tools were used to evaluate VRebalance. Study shows VRebalance is more effective than traditional methods, meeting SLO targets despite system changes. VRebalance decreased SLO violation rates by almost 30% for static priority-based workloads and 52.2% …


Experiences Of First-Generation Students In A Large Public University In Ghana : A Phenomenological Study, Jacob Oppong Nkansah Aug 2023

Experiences Of First-Generation Students In A Large Public University In Ghana : A Phenomenological Study, Jacob Oppong Nkansah

Lingnan Theses (Doctoral degree)

In this study, first-generation students (FGS) experiences in the higher education system of Ghana were explored. Only a few studies in Africa, notably Ghana, have focused on the concept of FGS. FGS are conceptualized as learners whose parents didn’t complete or attend university and are the first in their nuclear families to seek for higher education. This research looked into FGS experiences at the University of Education Winneba, which is a large public university viewed as a haven for FGS in Ghana because of its mandate to train teachers for immediate employment. The study explored FGS motivations for pursuing higher …


It's Nerve Racking: The Lived Experiences Of New Graduate Clinical Care Nurses Using Simulation As Part Of An Orientation Program, Robert L. Kerner Jr. Aug 2023

It's Nerve Racking: The Lived Experiences Of New Graduate Clinical Care Nurses Using Simulation As Part Of An Orientation Program, Robert L. Kerner Jr.

Dissertations

The nursing profession has adopted high fidelity simulation (HFS) on the premise that it provides suitable opportunities for experiential learning in a non-threatening environment and it will improve clinical skills and critical thinking through repetition and reflective practice. Numerous quantitative studies have examined the effect of HFS on skill acquisition, critical thinking and teamwork, predominantly with experienced clinicians. The voice of the learner has been conspicuously absent in the discussion. The phenomenon of interest in this study was the experience of simulation for new graduate nurses. The participants were recruited using a purposive technique, and each underwent a comprehensive interview, …


Analisis Kasus Kecelakaan Pemboran Pada Industri Migas Di Pt.X Berdasarkan Faktor Manusia Tahun 2022, Siti Khodijah, Mufti Wirawan Aug 2023

Analisis Kasus Kecelakaan Pemboran Pada Industri Migas Di Pt.X Berdasarkan Faktor Manusia Tahun 2022, Siti Khodijah, Mufti Wirawan

National Journal of Occupational Health and Safety

Oil and gas drilling activities have associated high risks. 80% of the causes of drilling accidents are caused by human performance. In 2020, drilling activities at PT. X accounts for 3 out of 8 accidents and the common cause that occurs due to human factors. Unsafe acts are the main cause of drilling accidents in the oil and gas industry. This study discusses the analysis of cases of oil and gas drilling accidents at PT.X from the point of view of human factors. The purpose of this study is to analyze the contributing factors of active and latent failure and …


Increasing Exercise In Individuals With Autism Spectrum Disorder: A Systematic Review Of Instructional Strategies, Jacob Moak Aug 2023

Increasing Exercise In Individuals With Autism Spectrum Disorder: A Systematic Review Of Instructional Strategies, Jacob Moak

Seton Hall University Dissertations and Theses (ETDs)

It has been found that children with autism spectrum disorder (ASD) are 1.6 times more likely to be obese compared to neurotypically developing children. Individuals with ASD often struggle with motor skills and experience sensory processing difficulties, which can make it difficult to participate in regular physical activity. Because of this, it is crucial to find exercise methods that are enjoyable, practical and that are tailored to the specific needs of individuals with ASD in order to help them maintain a healthy lifestyle. The current systematic review investigated the research literature on interventions used to teach exercise to individuals with …


The Effectiveness Of Microcurrent Neurofeedback On Depression, Anxiety, Post-Traumatic Stress Disorder, And Quality Of Life, Gloria Duke, Courtney N. Yotter, Beverly Sharifian, Gary Duke, Sandra Petersen Aug 2023

The Effectiveness Of Microcurrent Neurofeedback On Depression, Anxiety, Post-Traumatic Stress Disorder, And Quality Of Life, Gloria Duke, Courtney N. Yotter, Beverly Sharifian, Gary Duke, Sandra Petersen

Nursing Faculty Publications and Presentations

Background: The world faces a mental health crisis with elevated rates of depression, anxiety, and post-traumatic stress, leaving a profound impact on daily quality of life (QOL). Current treatments show varying degrees of efficacy and carry burdensome challenges. Evidence exists for use of an innovative neurotechnology to reduce symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD), but the science is lacking for use in the general population. Purposes: The purpose of this pilot study was to explore the effects of microcurrent neurofeedback on depression, anxiety, PTSD symptoms, and QOL in adults. Methodology: This was a one-group, exploratory pilot study …


Vertical Federated Learning Using Autoencoders With Applications In Electrocardiograms, Wesley William Chorney Aug 2023

Vertical Federated Learning Using Autoencoders With Applications In Electrocardiograms, Wesley William Chorney

Theses and Dissertations

Federated learning is a framework in machine learning that allows for training a model while maintaining data privacy. Moreover, it allows clients with their own data to collaborate in order to build a stronger, shared model. Federated learning is of particular interest to healthcare data, since it is of the utmost importance to respect patient privacy while still building useful diagnostic tools. However, healthcare data can be complicated — data format might differ across providers, leading to unexpected inputs and incompatibility between different providers. For example, electrocardiograms might differ in sampling rate or number of leads used, meaning that a …


Distributionally Robust Unsupervised Domain Adaptation And Its Applications In 2d And 3d Image Analysis, Yibin Wang Aug 2023

Distributionally Robust Unsupervised Domain Adaptation And Its Applications In 2d And 3d Image Analysis, Yibin Wang

Theses and Dissertations

Obtaining ground-truth label information from real-world data along with uncertainty quantification can be challenging or even infeasible. In the absence of labeled data for a certain task, unsupervised domain adaptation (UDA) techniques have shown great accomplishment by learning transferable knowledge from labeled source domain data and adapting it to unlabeled target domain data, yet uncertainties are still a big concern under domain shifts. Distributionally robust learning (DRL) is emerging as a high-potential technique for building reliable learning systems that are robust to distribution shifts. In this research, a distributionally robust unsupervised domain adaptation (DRUDA) method is proposed to enhance the …


Elucidating Self-Assembly Of Semiconducting Polymers In The Presence Of A Low Molecular Weight Gelator, Madhubhashini Lakdusinghe Aug 2023

Elucidating Self-Assembly Of Semiconducting Polymers In The Presence Of A Low Molecular Weight Gelator, Madhubhashini Lakdusinghe

Theses and Dissertations

Semiconducting polymers with a conjugated backbone are important for energy storage, conversion, and biomedical field applications. The self-assembly process of these polymers in solutions depends on the polymer concentration and quality of the solvent. The electrical properties of thin films obtained from the solution phase depend on the self-assembled process. Thin films of conjugated polymer gels with percolating networks of self-assembled structures display improved electrical conductivities. In this dissertation, we studied the impact of the secondary gel matrix formed by a low molecular weight gelator, on the self-assembly of conjugated polymers, the preservation of assembled structures in dried gel films …


Comparing Current Consistency And Electrical Resistance Of Wearable Photovoltaic Cells Pre- And Post-Laundering And Pre- And Post-Corrosion Resistance Testing Conditions., Amit Talukder Aug 2023

Comparing Current Consistency And Electrical Resistance Of Wearable Photovoltaic Cells Pre- And Post-Laundering And Pre- And Post-Corrosion Resistance Testing Conditions., Amit Talukder

Theses and Dissertations

Photovoltaic(PV) technology is promising due to its natural availability among energy harvesting technologies. There is a growing need for sustainable power sources that can function without being connected to a power source or needing regular battery replacements. Wearable PV cells are gaining popularity in different applications. However, most companies produce wearable PVs for terrestrial applications. Research on wearable PV applications for the marine environment remains limited because these cells suffer from several issues. This research compares commercially sourced wearable PV cells' maximum current consistency and electrical resistance for two testing conditions. The researcher followed standardized methods for these two laundering …


Dune To Shore: The Relationship Between Vegetative Dune Systems And Shoreline Stability In Barrier Islands, Walter Hastings Hogue Aug 2023

Dune To Shore: The Relationship Between Vegetative Dune Systems And Shoreline Stability In Barrier Islands, Walter Hastings Hogue

Theses and Dissertations

Dauphin, Petit Bois, and Horn Island form the Alabama gulf-barrier chain directly south of Mobile Bay. Many studies have targeted local climate stressors and the flux of longshore currents as factors for erosional and accretional changes on these islands, but little attention is paid to the degradation of their vegetative dune-systems as a contributor to their shoreline morphology (Hanley et al., 2014; Smith, 2018; Byrnes, 2010). This study fills this literary gap, utilizing GIS raster classification and Digital Shoreline Analysis System to measure vegetative health and shoreline change on these islands and verify a relationship between these two factors. The …


The Effects Of Mechanical Strain On Vascular Calcification And The Canonical Wnt Pathway, Hannah E. Douglas Aug 2023

The Effects Of Mechanical Strain On Vascular Calcification And The Canonical Wnt Pathway, Hannah E. Douglas

Theses and Dissertations

Cardiovascular disease is a significant health crisis, representing 32% of deaths worldwide in 2019. Vascular calcification (VC), a major contributor to cardiovascular disease, is a regulated biomineralization process whose exact mechanisms are unknown. Additionally, vascular smooth muscle cells (VSMCs) significantly contribute to VC by undergoing a phenotypic switch and differentiating into osteoblast-like cells. When factors like hypertension cause disturbed laminar flow in the body’s vasculature, the mechanical stress promotes the phenotypic switch and calcification of VSMCs via mechanotransduction. VC is also induced by the Wnt pathway, which is activated via mineral imbalance and mechanical stimulation. However, the exact mechanisms behind …


Leaf Area Index And Aboveground Biomass Estimation Of Populus And Its Hybrids Using Terrestrial Lidar, Surya Adhikari Aug 2023

Leaf Area Index And Aboveground Biomass Estimation Of Populus And Its Hybrids Using Terrestrial Lidar, Surya Adhikari

Theses and Dissertations

Short rotation woody crops (SRWC) eastern cottonwood (Populus deltoides) and hybrid poplar plantations were established in 2021 in Pontotoc and Oktibbeha counties of Mississippi to study the biomass potential of SRWC for biofuel production. We used a novel backpack LiDAR system to measure forest metrics and harvested sample trees to build aboveground biomass (AGB) and leaf area index (LAI) equations. The results showed that LiDAR-derived variables accurately estimated aboveground biomass (R2 =0.81 and 29.22 % RMSE). However, the LAI estimation results showed that the LiDAR metrics moderately explained field measurements of LAI (R2 =0.31 and 18.05% …


Nanoscale Modeling Of Membrane Systems Under Mechanical Deformation In Traumatic Brain Injury Using Molecular Dynamics, Anh Thi Ngoc Vo Aug 2023

Nanoscale Modeling Of Membrane Systems Under Mechanical Deformation In Traumatic Brain Injury Using Molecular Dynamics, Anh Thi Ngoc Vo

Theses and Dissertations

Neuronal membrane disruption and mechanoporation are nanoscale damage mechanisms that critically affect brain cell viability during traumatic brain injury (TBI). These nanoscale cellular impairments are elusive in experiments and necessitate in silico approaches such as molecular dynamics (MD) simulations. Implementing MD, this research aims to investigate the effects of different key factors related to membrane deformation and damage, including force field resolutions, lipid compositions, and loading conditions.

To examine the impact of force field resolution, MD deformation simulations were conducted on 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) lipid bilayer membranes, using all-atom (AA), united-atom (UA), and coarse-grained Martini (CG-M) force fields. The mechanical responses …


The Cosolvent And Association Effect On Polymer Behaviors, Xiangyu Zhang Aug 2023

The Cosolvent And Association Effect On Polymer Behaviors, Xiangyu Zhang

Theses and Dissertations

The blending or mixing is extensively utilized in diverse processes of polymers to bring about advantageous properties, but the behavior becomes intriguing when associations are involved and multi-solvents are used. Explanations based on chemistry-specific arguments are less than satisfactory in abstracting essential features, and lack the general applicability across various systems. So, this work focuses on capturing the physical force governing the phenomenon of interest by using a generic model. Highly non-trivial behaviors of polymers are often observed in multi-solvent solutions. It is known that polymers swell and dissolve in good solvents, while they tend to collapse and aggregate in …