Digital Commons Network^™

Stat3 Modulates Cd4+ T Mitochondrial Dynamics And Function In Aging, Emelia Zukowski, Marco Sannella, Jack Donato Rockhold, Gabriella H. Kalantar, Jingting Yu, Sara Santacruz‐Calvo, Madison K. Kuhn, Nasun Hah, Ling Ouyang, Tzu‐Wen Wang, Lyanne Murphy, Heather Marszalkowski, Kaleigh Gibney, Micah J. Drummond, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath

Health Sciences Faculty Publications

Aging promotes numerous intracellular changes in T cells that impact their effector function. Our data show that aging promotes an increase in the localization of STAT3 to the mitochondria (mitoSTAT3), which promotes changes in mitochondrial dynamics and function and T‐cell cytokine production. Mechanistically, mitoSTAT3 increased the activity of aging T‐cell mitochondria by increasing complex II. Limiting mitoSTAT3 using a mitochondria‐targeted STAT3 inhibitor, Mtcur‐1 lowered complex II activity, prevented age‐induced changes in mitochondrial dynamics and function, and reduced Th17 inflammation. Exogenous expression of a constitutively phosphorylated form of STAT3 in T cells from young adults mimicked changes in mitochondrial dynamics and …

Transportation Planning In An Aging Society, Shengxiao (Alex) Li

PSU Transportation Seminars

By 2030, all Baby Boomers (those born between 1946 and 1964) will be 65 and older in the U.S. However, the understanding of how Baby Boomers travel differently from the previous generations, and the opportunities and challenges of older people's travel, do not keep pace with the increasing number of older people. This presentation starts with an overview of transportation policies for older people and challenges, followed by several empirical studies investigating older people's generational travel differences, vehicle ownership over the life course, and the interaction of technology usage and travel among older people. It concludes with a policy agenda …

Understanding First-Year Rn Turnover And Retention Strategies: An Integrative Review, Kelly Rose Swirple

Doctoral Dissertations and Projects

The purpose of this integrative review was to identify themes within the literature related to the first-year turnover of new graduate nurses within the hospital setting and what nursing leaders can do or have done to increase retention. This review was not intended to evaluate specific interventions implemented in response to turnover, such as nurse residencies, transition to practice, and mentorship programs. This review’s overall purpose was to better understand why new nurses leave their jobs within the first 12 to 24 months, the best practices to reduce first-year turnover, and how nursing leaders best support new graduates. According to …

Detection And Prevention Of Type 2 Diabetes For Women With A History Of Gestational Diabetes: An Integrative Review, Pamela Brinn

Doctoral Dissertations and Projects

Gestational diabetes mellitus, among the most frequent complications occurring during pregnancy, affects approximately 8% 10% of pregnant women. These women are at a much higher risk of developing type 2 diabetes mellitus later in life. Concerningly, during the transition from obstetrical care to primary care, women with gestational diabetes often miss the required follow-up testing, preventive care, and education on lifestyle changes that could prevent or delay the development of type 2 diabetes mellitus. This integrative review analyzed current evidence on detecting and preventing type 2 diabetes mellitus in women with a history of gestational diabetes. Four essential themes appeared …

Reducing Readmission Rates In Adult Patients (18–25 Years) With Alcohol And Substance Use Disorder Through Implementation Of Care Coordination Strategy: An Integrative Review, Godswill Evouka

Doctoral Dissertations and Projects

Alcohol and substance use disorders are a major issue in adults ages 18 to 25. According to the 2021 National Survey on Drug Use and Health, 6.6 million young adults ages 18 to 25 reported that they drank alcohol in the past month, and 2.4 million young adults ages 18 to 25 reported heavy alcohol use in the past. Over 20 million alcohol use cases were reported in the past year in the United States. Further, 21.6% of patients with drug use disorders were readmitted to hospitals within 30 days of discharge. Adults ages 18 to 25 years who are …

Recommendations To Solve The Problem Of Low Map Growth Reading Scores For Ninth And Tenth Grade Students At Christopher Columbus High School, Luis M. Villanueva

Doctoral Dissertations and Projects

The purpose of this study was to provide recommendations to solve the problem of low Reading scores on the Measure of Academic Progress (MAP) Growth test for ninth and tenth graders at Christopher Columbus High School (CCHS) in Florida. The problem was that 52.7% of the students at CCHS that took the MAP Growth test during the 2021-2022 school year were not at their corresponding grade level in Reading (CCHS, 2022). The rationale for this study was that it is critical to assist the first and second-year students at CCHS in improving their reading competencies – one of two sections, …

A Qualitative Analysis Of Corporate Responsibility For The Education Of U.S. Citizens, Heidi Leslie O'Donnell

Doctoral Dissertations and Projects

Educated and trained workers represent the primary critical success factor needed for all organizations to achieve their mission. Organizations depend on a constant flow of educated applicants competing for their jobs at any given time. Traditionally, public, private, and charter schools prepared U.S. citizens for college, trade schools, military, or university, enabling them to then compete successfully for jobs of the era. Today, a myriad of problems face these schools, including disruptive change, uninvolved parents, lack for funding, teacher unions, politics, school overcrowding, COVID-19, outdated training methods, security, race issues, and more. The result is that this education model is …

Implementation Of Nutritional Screening In Adults (Ages 19-65) With Major Depressive Disorder: An Integrative Review, Laurie S. Stephens

Doctoral Dissertations and Projects

The World Health Organization estimates the total percentage of depression at 3.8% and projects it to be the leading cause of global disability by 2030 (WHO, 2023). The economic burden for adults with major depressive disorder in the United States is estimated at a staggering annual cost of 236 billion dollars (Greenberg et al., 2018). Nutritional psychiatry is a growing subspecialty focused upon how diet can improve mental health outcomes. The evidence shows a correlation between diet and depression, influencing questions on how this translates to current dietary recommendations and treatment. An integrative review of current literature was performed to …

A Phenomenological Study Of Teachers' Lived Experiences With Cell Phones In The Classroom, Matthew Dado

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to discover high school teachers' experiences with cell phones in the classrooms during instructional time at Quaker High School. The theory guiding this study is Jean Piaget's constructivism theory, as it argues that knowledge is produced, and meaning is formed through the experiences of one's physical or mental actions in their environment. The methodology for this dissertation includes a study design that utilizes a phenomenological study method and consists of thirteen teachers from various backgrounds and locations. The setting for the study is a high school in Pittsburgh, PA. The data collection and …

Comparison Of Post Discharge Telephone Call Methods And Their Impact On Patient Outcomes And Satisfaction: An Integrative Review, Amanda Thacker Mikolay

Doctoral Dissertations and Projects

Discharge planning and education may directly influence patient outcomes, including patient satisfaction and readmission rates. Discharge techniques and follow-up practices vary across departments and facilities. Follow-up telephone calls after patient discharge are commonly utilized; however, delivery techniques differ across health care areas. The purpose of this integrative review is to explore the various techniques of initiating postdischarge follow-up phone calls and their impact on patient outcomes and satisfaction. For this review, the conceptual definition of a telephone follow-up call is a particular method of contacting a patient after discharge. Methods examined in this review were calls by a registered nurse/advanced …

Crossroads In History That Determined Whether Sun Valley Would Be Built, John W. Lundin

Works by Local Authors

No abstract provided.

Oral History Interview: Cheryl Mchenry, Whio-Tv News Anchor, Cheryl Mchenry, Elizabeth Barker, Matthew Brown

Miami Valley Personalities: Their Stories, Their Words

Oral history interview with Cheryl McHenry, who took her first job at WHIO-TV as a news reporter in 1981.

Faculty Feed, October 13, 2023, College Of Arts & Sciences

News, Magazines and Reports

Recent student and faculty accomplishments.

Interval-Valued Fermatean Neutrosophic Shortest Path Problem Via Score Function, Said Broumi, S. Krishna Prabha, Vakkas Uluçay

Neutrosophic Systems with Applications

Contemporary mathematical techniques have been crafted to address the uncertainty of numerous real-world settings, including Fermatean neutrosophic fuzzy set theory. Fermatean neutrosophic fuzzy set is an extension of combining Fermatean and neutrosophic sets. A Fermatean neutrosophic set was developed to enable the analytical management of ambiguous data from relatively typical real-world decision-making scenarios. Decision-makers find it challenging to determine the degree of membership (MG) and non-membership (NG) with sharp values due to the insufficient data provided. Intervals MG and NG are suitable options in these circumstances. In this article, the shortest route issue is formulated using an interval set of …

Ppp1r12c Promotes Atrial Hypocontractility In Atrial Fibrillation, Frederick W Damen, Laurin M Hanft, Ken S Lizama, Anahita Aboonabi, Andrielle E Capote, Yuriana Aguilar-Sanchez, Benjamin Levin, Zhenbo Han, Arvind Sridhar, Jacob Grand, Jody Martin, Joseph G Akar, Chad M Warren, R John Solaro, Sang-Ging Ong, Dawood Darbar, Kerry S Mcdonald, Craig J Goergen, Beata M Wolska, Dobromir Dobrev, Xander H T Wehrens, Mark D Mccauley

Faculty, Staff and Students Publications

Background: Atrial fibrillation (AF)-the most common sustained cardiac arrhythmia-increases thromboembolic stroke risk 5-fold. Although atrial hypocontractility contributes to stroke risk in AF, the molecular mechanisms reducing myofilament contractile function remain unknown. We tested the hypothesis that increased expression of PPP1R12C (protein phosphatase 1 regulatory subunit 12C)-the PP1 (protein phosphatase 1) regulatory subunit targeting MLC2a (atrial myosin light chain 2)-causes hypophosphorylation of MLC2a and results in atrial hypocontractility.

Methods: Right atrial appendage tissues were isolated from human patients with AF versus sinus rhythm controls. Western blots, coimmunoprecipitation, and phosphorylation studies were performed to examine how the PP1c (PP1 catalytic subunit)-PPP1R12C interaction …

The Diamond, October 13, 2023, Dordt University

Dordt Diamond

• Front Page: Defender Crazies Re-Ignites Dordt Athletics; Somdi Baccam: The Man Behind the Camera; Marine Band Shares Gift of Music with Dordt Community
• News: Dordt Adds Off Campus Study Program in Baltimore; What Happens if the Government Shuts Down?; Caleb Meulenberg Brings Industry Experience to the Ag Teach [sic] Program
• Feature: International Friendship Family Program Shares Culture; Senior Recital Highlights Violin and Organ; Dordt Chapel: Hearing God's Voice; What Do Professors Do Over Heartland?
• Arts & Entertainment: Kylie Sorensen Takes the Stage in Senior Voice Recital; Beautiful Things: Dordt Worship Releases New Singles; D'Arte Club Hosts …

Contemplation Of Improvement Efforts To Manage Combined Sewer Overflows †, Younghan Edwin Jung, Myung Jeong, Hwandon Jun, Trevor Smith

Civil Engineering & Construction: Faculty Publications

Combined sewer overflow (CSO) is a significant environmental concern and public health risk (e.g., water contamination, eutrophication, and beach closure). The Environmental Protection Agency (EPA) has introduced the National Pollutant Discharge Elimination System (NPDES) permitting program to regulate and address this matter. This program mandates the control of CSOs for more than 700 municipalities obligated to devise Long-term Control Plans (LTCPs) to curb combined sewer overflows and reduce them to safe levels. The LTCP involves diverse strategies, including sewer separation, green infrastructure improvements, and conventional gray infrastructure upgrades. This study investigates several municipalities’ solutions for CSO problems that use conventional …

World War Two Glider Borne Forces: The Role Of British Doctrine In Effective Military Change, John W. Stegall

Masters Theses

The United States’ National Defense Strategy has shifted from fighting an asymmetrical, fourth generation adversary utilizing counterinsurgency and unconventional warfare to preparing for a peer/near peer conventional conflict focused on the Pacific and Central Europe. Modern maneuver commanders and operational planners can apply the economy of force, criticality of speed plus precision in kinetic engagements, value of highly trained, task organized small units, and technological incorporation knowledge gathered from analyzing the World War II glider operations executed by Germany, Great Britain, and the United States. Gliders were sailplanes that had a higher ratio of lift to drag than a motorized …

Use Of Recycled Aggregate Concrete In Structural Members: A Review Focused On Southeast Asia, Ram Prasad Neupane, Thanongsak Imjai, Natt Makul, Reyes Garcia, Boksun Kim, Sandeep Chaudhary

School of Engineering, Computing and Mathematics

This article presents a comprehensive review on the use of recycled concrete aggregate (RCA) and recycled aggregate concrete (RAC) in construction, with emphasis on structural applications and identification of challenges and opportunities of RCA/RAC materials in Southeast Asia. For the first time and as a first step towards potential standardization of RCA/RAC in Southeast Asia, the article critically examines the physical and mechanical performance of RCA and RAC in structural applications. Global aggregate demand is projected to surpass 50 billion tons by 2025, with major Asian countries accounting for 62% of consumption. At the same time, the global annual production …

A Hermeneutic Phenomenological Study Of American And British Military Bandmasters’ Experiences And The Influence On The Development Of The American Public School Band Movement, Michael L. Burrage

Doctoral Dissertations and Projects

This study investigates the history of British and American Military Bandmasters’ lived experiences through a Phenomenological Hermeneutic Analysis construct to the development of the Public-School Band movement. This thesis aims to provide insight through transcribed interviews, historical documentation, and pre-recorded transcriptions of the thoughts and practical influences of developing the effectiveness of band teacher preparation in American public school band programs. A better understanding of these advances warrants a comprehensive overview of military band history and a sense of how the curriculum process, formation, and growth in British and American Military Bands influenced approaches and philosophical thought through experiences of …

Experiences Of Middle School Teachers Implementing The Flipped Classroom Method With Lack Of Student Preparedness: A Transcendental Phenomenological Study, Kristine K. Hickman

Doctoral Dissertations and Projects

The purpose of this qualitative, transcendental phenomenological study was to describe the lived experiences of middle school teachers in the United States implementing the flipped classroom model (FCM) when students are not coming to class prepared. The FCM is a framework in which students engage in passive learning activities at home by watching videos uploaded by their teachers so that they can engage in active learning activities in the classroom. The theory guiding this study is Vygotsky’s social-constructivism theory as it promotes critical thinking and problem-solving skills through collaboration, which are very important skills required of today’s 21st century learners. …

First-Year Teacher Stress And The Impact On Teacher-Student Relationships, Andrea Michelle Forcum

Doctoral Dissertations and Projects

The purpose of this case study is to understand how stress impacts first-year, 7th-12th grade teachers’ relationships with their students at Green County Schools. The theory guiding this study is the cognitive appraisal theory from Lazarus and Folkman, as it describes the impact of a person’s appraisal of stress and how it influences the perspective of individuals. As first-year teachers are framing their experiences for the first time, this approach helps contextualize how they cope and affect their relationships. This framework will serve as a framework for all the research and data collection. The method used for this case study …

How The Input-Process-Output Model Affects The Decoding Of Internal Strategic Financial Communication By Non-Financial Branch Managers, Andrew James Schell

Doctoral Dissertations and Projects

The purpose of this instrumental case study was to explore how non-financial branch managers at US mortgage companies processed the decoding of internal strategic financial communication (ISFC) when the message was encoded by the language of numbers (LON). The LON includes Generally Accepted Accounting Principles (GAAP). A non-financial branch manager is an individual who manages a mortgage company branch office and may not possess LON decoding proficiency. This lack of LON decoding proficiency could result in ISFC decoding errors, potentially resulting in unintended financial consequences. Financial miscommunication is connected to the failure of over 50% of new small businesses each …

A Phenomenological Study On Perceived Academic And Social Factors That Attribute To The Collegiate Success Or Failure Of Low-Income, First-Generation Black Males, Tre' Antonio Finklea

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to analyze and discover the factors that contributed to the success or failure of first-generation Black male collegiates at four-year institutions and effectively provide an in-depth understanding of these issues. The theory guiding this study was Tinto’s theory of integration, which focuses on the norms of academic and social integration. Related to this theory was a series of studies that presented the idea that students’ involvement in the social environment and educational setups were critical to their success and retention in college. Participants completed a questionnaire to determine their eligibility for the study. …

Machine Learning‑Assisted Low‑Dimensional Electrocatalysts Design For Hydrogen Evolution Reaction, Jin Li, Naiteng Wu, Jian Zhang, Hong‑Hui Wu, Kunming Pan, Yingxue Wang, Guilong Liu, Xianming Liu, Zhenpeng Yao, Qiaobao Zhang

Department of Chemistry: Faculty Publications

Efficient electrocatalysts are crucial for hydrogen generation from electrolyzing water. Nevertheless, the conventional "trial and error" method for producing advanced electrocatalysts is not only cost-ineffective but also time-consuming and labor-intensive. Fortunately, the advancement of machine learning brings new opportunities for electrocatalysts discovery and design. By analyzing experimental and theoretical data, machine learning can effectively predict their hydrogen evolution reaction (HER) performance. This review summarizes recent developments in machine learning for low-dimensional electrocatalysts, including zero-dimension nanoparticles and nanoclusters, one-dimensional nanotubes and nanowires, two-dimensional nanosheets, as well as other electrocatalysts. In particular, the effects of descriptors and algorithms on screening low-dimensional electrocatalysts …

Bpsou Buffalo Gulch Forebay Parcel 2023 Expedited Well Abandonment Plan, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Deep Learning For Plant Bioinformatics: An Explainable Gradient-Based Approach For Disease Detection, Muhammad Shoaib, Babar Shah, Nasir Sayed, Farman Ali, Rafi Ullah, Irfan Hussain

All Works

Emerging in the realm of bioinformatics, plant bioinformatics integrates computational and statistical methods to study plant genomes, transcriptomes, and proteomes. With the introduction of high-throughput sequencing technologies and other omics data, the demand for automated methods to analyze and interpret these data has increased. We propose a novel explainable gradient-based approach EG-CNN model for both omics data and hyperspectral images to predict the type of attack on plants in this study. We gathered gene expression, metabolite, and hyperspectral image data from plants afflicted with four prevalent diseases: powdery mildew, rust, leaf spot, and blight. Our proposed EG-CNN model employs a …

Evaluation Of Novel Jointless Engineered Cementitious Composites Ultrathin Whitetopping (Ecc-Utw), Ricardo Hungria

LSU Doctoral Dissertations

Ultrathin Whitetopping (UTW) is a rehabilitation technique that consists of placing a thin layer of concrete over a damaged asphalt pavement. While UTWs have demonstrated satisfactory performance in field tests, the inherent brittleness of concrete has led to the appearance of distresses. To address these distresses, Engineered Cementitious Composites (ECC) have been proposed for UTW applications, thanks to their exceptional attributes, including tensile ductility, flexural performance, and fatigue resistance. In this study, an ECC-UTW was constructed to investigate its potential as a viable solution. The project comprised two 18.3 m ECC sections with different thicknesses, namely 63.5 mm and 101.6 …

Centering Intersectional Sustainability In Leadership Education: A Case For The Sustainable Development Goals, Kate Sheridan, Whitney Mcintyre Miller, Rian Satterwhite

Education Faculty Articles and Research

Sustainability leadership has the transformative potential of helping to center an array of skills and mindsets needed for leaders and leaderful organizations and collectives to successfully address the many interrelated and connected challenges of the 21st century. This article makes the case that the United Nations Sustainable Development Goals (SDGs) are a useful framework for integrating sustainability into leadership education and development broadly and can advance these needed skill sets and learning orientations. Leadership educators should consider centering this in their work in order to effectively prepare learners for the challenges of today and tomorrow.

Guide-Specific Loss Of Efficiency And Off-Target Reduction With Cas9 Variants, Liang Zhang, Wei He, Rongjie Fu, Shuyue Wang, Yiwen Chen

Faculty, Staff and Student Publications

High-fidelity clustered regularly interspaced palindromic repeats (CRISPR)-associated protein 9 (Cas9) variants have been developed to reduce the off-target effects of CRISPR systems at a cost of efficiency loss. To systematically evaluate the efficiency and off-target tolerance of Cas9 variants in complex with different single guide RNAs (sgRNAs), we applied high-throughput viability screens and a synthetic paired sgRNA-target system to assess thousands of sgRNAs in combination with two high-fidelity Cas9 variants HiFi and LZ3. Comparing these variants against wild-type SpCas9, we found that ∼20% of sgRNAs are associated with a significant loss of efficiency when complexed with either HiFi or LZ3. …