Digital Commons Network^™

Impact Of Silicon Ion Irradiation On Aluminum Nitride-Transduced Microelectromechanical Resonators, David D. Lynes, Joshua Young, Eric Lang, Hengky Chandrahalim

Faculty Publications

Microelectromechanical systems (MEMS) resonators use is widespread, from electronic filters and oscillators to physical sensors such as accelerometers and gyroscopes. These devices' ubiquity, small size, and low power consumption make them ideal for use in systems such as CubeSats, micro aerial vehicles, autonomous underwater vehicles, and micro-robots operating in radiation environments. Radiation's interaction with materials manifests as atomic displacement and ionization, resulting in mechanical and electronic property changes, photocurrents, and charge buildup. This study examines silicon (Si) ion irradiation's interaction with piezoelectrically transduced MEMS resonators. Furthermore, the effect of adding a dielectric silicon oxide (SiO₂) thin film is …

Long Non-Coding Rna Snhg8 Drives Stress Granule Formation In Tauopathies, Reshma Bhagat, Miguel A Minaya, Arun Renganathan, Muneshwar Mehra, Jacob Marsh, Rita Martinez, Abdallah M Eteleeb, Alissa L Nana, Salvatore Spina, William W Seeley, Lea T Grinberg, Celeste M Karch

2020-Current year OA Pubs

Tauopathies are a heterogenous group of neurodegenerative disorders characterized by tau aggregation in the brain. In a subset of tauopathies, rare mutations in the MAPT gene, which encodes the tau protein, are sufficient to cause disease; however, the events downstream of MAPT mutations are poorly understood. Here, we investigate the role of long non-coding RNAs (lncRNAs), transcripts >200 nucleotides with low/no coding potential that regulate transcription and translation, and their role in tauopathy. Using stem cell derived neurons from patients carrying a MAPT p.P301L, IVS10 + 16, or p.R406W mutation and CRISPR-corrected isogenic controls, we identified transcriptomic changes that occur …

A Human Mitofusin 2 Mutation Can Cause Mitophagic Cardiomyopathy, Antonietta Franco, Jiajia Li, Daniel P Kelly, Ray E Hershberger, Ali J Marian, Renate M Lewis, Moshi Song, Xiawei Dang, Alina D Schmidt, Mary E Mathyer, John R Edwards, Cristina De Guzman Strong, Gerald W Dorn

2020-Current year OA Pubs

Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is 15-20× over-represented in clinical cardiomyopathy, whereas this specific mutation is not reported as a cause of MFN2 mutant-induced peripheral neuropathy, Charcot-Marie-Tooth disease type 2A (CMT2A). Accordingly, we interrogated the enzymatic, biophysical, and functional characteristics of MFN2 Q400 versus wild-type and CMT2A-causing MFN2 mutants. All MFN2 mutants had impaired mitochondrial fusion, the canonical MFN2 function. Compared to MFN2 T105M that lacked catalytic GTPase activity and exhibited normal …

Quality And Reliability Of Spanish-Language Youtube Videos On Breast Cancer, Fernando C. Diaz, Michael Lapelusa, Hansapani Rodrigo, Ismael Polo Perez, Dailis S. Corria Cedeno, Henry Kwang

School of Medicine Publications

As the number of Spanish- speaking patients with cancer in the USA grows, it is vital that reliable online breast cancer information is available in Spanish. The main objective of our study was to determine the quality and reliability of online videos in Spanish regarding breast cancer. We conducted a YouTube search using the phrase "cancer de mama" (breast cancer) and graded their quality and reliability using the Journal of the American Medical Association (JAMA) Benchmark Criteria, Global Quality Score (GQS), and the Modified DISCERN Questionnaire. Videos were characterized by descriptive variables. Videos were primarily from Spain (36.4%) and Mexico …

Digital Twins Of The Living Knee: From Measurements To Model, Thor Erik Andreassen

Electronic Theses and Dissertations

Modern medicine has dramatically improved the lives of many. In orthopaedics, robotic surgery has given clinicians superior accuracy when performing interventions over conventional methods. Nevertheless, while these and many other methods are available to ensure treatments are performed successfully, far fewer methods exist to predict the proper treatment option for a given person. Clinicians are forced to categorize individuals, choosing the best treatment on “average.” However, many individuals differ significantly from the “average” person, for which many of these treatments are designed. Going forward, a method of testing, evaluating, and predicting different treatment options' short- and long-term effects on an …

Kinematic Analysis Of Gait And Deep Knee Flexion For Pre- And Post-Operative Total Knee Arthroplasty, Samantha Collins

Electronic Theses and Dissertations

Osteoarthritis (OA) is a form of arthritis that develops in the joint due to overuse and aging causing pain, discomfort, and disability. Total Knee Arthroplasty (TKA) is a surgical procedure performed when OA symptoms are severe with an estimated 600,000 patients in the United States currently receiving TKA. Studies have reported dissatisfaction of the knee for 14-39% of patients. This study collected knee kinematics before and after surgery using stereo radiography for precise measurement of gait and deep knee flexion activities. Results showed healthy knee kinematics were not restored and no significant changes could be seen from OA kinematics in …

Seeking Sisterhood: An Exploratory Qualitative Inquiry Into The Sorority Rejection Experiences Of Black Women, Jasmine Michelle Pulce

Electronic Theses and Dissertations

In response to a call to fill the gap left by previous studies on collegiate sorority rejection, this study explored the meaning Black women ascribe to experiences of rejection from historically Black sororities. Using Black feminist thought and sista circle methodology, this study introduced narratives from five Black women who came together to comprise a collective standpoint. To better understand this phenomenon, study participants completed individual interviews, two Sista Circles, and one reflection survey. Three main findings were the interconnectedness of Black Greek-letter organizations and Black subcommunities at predominantly white institutions, the nonlinear nature of the Black sorority rejection experience, …

Effects Of Jaw Clenching And Mental Stress On Persistent Inward Currents Estimated By Two Different Methods, Ricardo N. O. Mesquita, Janet L. Taylor, Gabriel S. Trajano, Aleš Holobar, Basílio A. M. Gonçalves, Anthony J. Blazevich

Research outputs 2022 to 2026

Spinal motoneuron firing depends greatly on persistent inward currents (PICs), which in turn are facilitated by the neuromodulators serotonin and noradrenaline. The aim of this study was to determine whether jaw clenching (JC) and mental stress (MS), which may increase neuromodulator release, facilitate PICs in human motoneurons. The paired motor unit (MU) technique was used to estimate PIC contribution to motoneuron firing. Surface electromyograms were collected using a 32-channel matrix on gastrocnemius medialis (GM) during voluntary, ramp, plantar flexor contractions. MU discharges were identified, and delta frequency ( F), a measure of recruitment–derecruitment hysteresis, was calculated. Additionally, another technique was …

P2y2 Purinergic Receptor Gene Deletion Protects Mice From Bacterial Endotoxin And Sepsis-Associated Liver Injury And Mortality, Janielle P Maynard, Kelsey M Stayer, Eric Dybbro, Subapradha Narayanan, Aalekhya Biswas, Saliha Pathan, Krishnakant Soni, Abu Hena Mostafa Kamal, Chandra Shekar R Ambati, Nagireddy Putluri, Moreshwar S Desai, Sundararajah Thevananther

Faculty, Staff and Students Publications

Prostate cancer (PCa) remains a leading cause of mortality among American men, with metastatic and recurrent disease posing significant therapeutic challenges due to a limited comprehension of the underlying biological processes governing disease initiation, dormancy, and progression. The conventional use of PCa cell lines has proven inadequate in elucidating the intricate molecular mechanisms driving PCa carcinogenesis, hindering the development of effective treatments. To address this gap, patient-derived primary cell cultures have been developed and play a pivotal role in unraveling the pathophysiological intricacies unique to PCa in each individual, offering valuable insights for translational research. This review explores the applications …

Mems Cantilever Biosensors Driven By Fringe Effect: Voltage-Amplitude Response Of Parametric Resonance, Miguel A. Martinez, Dumitru I. Caruntu

Mechanical Engineering Faculty Publications

This paper deals with voltage-amplitude response of fringing field/effect actuated micro-electromechanical system (MEMS) cantilever beam resonator biosensors at parametric resonance. The system consists of a flexible electrode (cantilever beam) and a fixed electrode (ground plate) in parallel, connected through an AC voltage source. The electrostatic force induced is due to the parallel-plate capacitance, which is directly related to the overlapping area of the two electrodes (Palmer’s Formula). In addition, fringing field electrostatic actuation must be accounted for. This is due to the bending of electric field lines from the ground plate to the top and side walls of the cantilever …

Amplitude-Voltage Response Of Parametric Resonance Of Electrostatically Actuated Circular Membranes, Marcos Alipi, Dumitru I. Caruntu

Mechanical Engineering Faculty Publications

This paper deals with the amplitude-voltage response of parametric resonance of electrostatically actuated MEMS circular membranes resonator for sensing applications. The system consists of a flexible circular membrane over a parallel ground plate. A soft AC voltage is applied between the MEMS membrane and ground plate to actuate the membrane near its first natural frequency. Two methods of investigation are used in this research, namely the method of multiple scales (MMS), and the reduced order model (ROM). These methods were used to solve for the voltage response of the MEMS analytically and numerically. This work also reports the effects the …

Baseline Leptin Predicts Response To Metformin In Adolescents With Type 1 Diabetes And Increased Body Mass Index, Ashutosh Sabharwal, Ingrid Libman, Fida Bacha, Kristen J Nadeau, Mustafa Tosur, Maria J Redondo

Faculty, Staff and Students Publications

No abstract provided.

Emergent Radiotherapy For Brain And Leptomeningeal Metastases: A Narrative Review, Vyshak Venur, Balamurugan Vellayappan, Joshua Palmer, Lia M Halasz, Jonathan T Yang, Molly Blau, Yolanda D Tseng, Samuel T Chao, John H Suh, Matthew Foote, Kristin J Redmond, Stephanie E Combs, Eric L Chang, Arjun Sahgal, Simon S Lo

Faculty, Staff and Students Publications

Background and objective: As novel systemic therapies allow patients to live longer with cancer, the risk of developing central nervous system (CNS) metastases increases and providers will more frequently encounter emergent presentation of brain metastases (BM) and leptomeningeal metastases (LM). Management of these metastases requires appropriate work-up and well-coordinated multidisciplinary care. We set out to perform a review of emergent radiotherapy (RT) for CNS metastases, specifically focusing on BM and LM.

Methods: We review the appropriate pathways for workup and initial management of BM and LM, while reviewing the literature supporting emergent treatment of these entities with surgery, systemic anti-cancer …

Refining Chimeric Antigen Receptors Via Barcoded Protein Domain Combination Pooled Screening, Pradyot Bhattacharya, Yibin Chen, Linjie Guo, Chunchao Zhang, Erica J Di Pierro, Gengwen Tian, Gabriel A Barragan, Pavel Sumazin, Leonid S Metelitsa

Faculty, Staff and Students Publications

Chimeric antigen receptor (CAR)-T cells represent a promising frontier in cancer immunotherapy. However, the current process for developing new CAR constructs is time consuming and inefficient. To address this challenge and expedite the evaluation and comparison of full-length CAR designs, we have devised a novel cloning strategy. This strategy involves the sequential assembly of individual CAR domains using blunt ligation, with each domain being assigned a unique DNA barcode. Applying this method, we successfully generated 360 CAR constructs that specifically target clinically validated tumor antigens CD19 and GD2. By quantifying changes in barcode frequencies through next-generation sequencing, we characterize CARs …

Best Therapeutic Practices In The Management Of Obstetric Sepsis, Gabriel Petre Gorecki, Oana Denisa Balalau, Diana Elena Comandasu, Anca Daniela Stanescu, Dana Rodica Tomescu

Journal of Mind and Medical Sciences

Background. Physiological changes that occur during pregnancy make maternal sepsis a difficult condition to diagnose and treat, still having a fairly high mortality rate. Consequently, an early diagnosis and prompt therapeutic management of sepsis can significantly decrease mortality. The purpose of this study is to review literature data that present current practices in the management of obstetric sepsis. Methods. To collect the data required for the study, we performed a search of published articles in the PubMed and Google Scholar databases related to obstetric sepsis. Research paper articles from the period 2012-2022 were included in the analysis. In addition, 145 …

Psychological Violence And Manipulative Behavior In Couple: A Focus On Personality Traits, Carmela Mento, Clara Lombardo, Nicholas Whithorn, Maria Rosaria Anna Muscatello, Antonio Bruno, Maura Casablanca, Maria Catena Silvestri

Journal of Mind and Medical Sciences

Psychological violence is characterized by systematic denigration and humiliation of the partner (victim). It is an insidious and manipulative behavior put in place to ensure that the victim begins to doubt themselves, and their own judgments, to the point of feeling confused and wrong. This behavior pattern is called Gaslighting and the personality traits are characterized by lack of empathy, psychopathy, narcissism and Machiavellianism. These three conditions are part of the so-called dark triad and distinguished by the lack of empathy. The aim of this study is to explore psychological aspects and consequences of Gaslighting phenomena. This systematic review was …

It’S All About Fishing: Robert Ellis Jenkins (1940-2023) And His Life Among Freshwater Fishes Of Virginia And The Redhorse Suckers, Eric J. Hilton

Southeastern Fishes Council Proceedings

Robert (Bob) Ellis Jenkins passed away in Salem, Virginia, on Wednesday, July 12, 2023. Bob was born February 9, 1940 in Brooklyn, New York. As a child, Bob took an early interest in natural history, and was a particularly avid fisherman. He attended Roanoke College (Salem, VA) as an undergraduate and entered into a Masters degree program at Virginia Tech (Blacksburg, VA), only to leave before finishing for a position at the NOAA Systematics Lab based at the Smithsonian Institution’s National Museum of Natural History. He eventually became faculty at his alma mater, Roanoke College, where he would spend virtually …

Design And Application Of Circular Edge-Fed Linearly Polarized Patch Antenna With Enhanced Bandwidth And Gain For Respiratory Monitoring Systems, Mo’Ath Akram Al Hayek

Thesis/ Dissertation Defenses

This Master's thesis explores the design and application of a circular edge-fed patch antenna for respiratory monitoring systems. The antenna, fabricated from a thin copper adhesive sheet, demonstrates compatibility with textile materials of low thickness and a relative permittivity of 1.3. Using CST Studio Suite 3D EM simulation software, the antenna's design was optimized through extensive trials, achieving improved bandwidth and gain. Our findings indicate that the antenna successfully differentiates between various breathing patterns, including slow, normal, and fast breathing rates. The study's managerial and research implications extend to healthcare, wearable technology sectors, and the broader scientific community. The research …

Investigating The Gut Microbiota Of Skeleton Shrimp, Jason Rosales

Trick to the Treat of Internships and Research

No abstract provided.

Mentorship In Counselor Education: A Scoping Review, Gideon Litherland, Gretchen Schulthes, Edward Ewe, Kaj Kayij-Wint, Kok-Mun Ng

Teaching and Supervision in Counseling

Mentorship has been widely lauded as meaningful for trainees in their professional development. To better understand the gaps in the scholarship of mentorship in counselor education, a scoping review was conducted to examine peer-reviewed research from 2005-2020. Results found eligible articles (n = 18) met the eligibility criteria. Implications from this study include improving conceptual rigor of mentorship outcomes in counselor education research, further investigating how underrepresented identities may benefit from mentorship, and tailoring mentorship interventions for the learning context and graduate level for counselor education students.

Book Review: I Was A Nascar Redneck: Recollections Of The Transformation Of A Yankee Farm Boy To A Southern Redneck In The Golden Era Of Nascar And Beyond., Quinn Beekwilder, Daniel Dean

Journal of Motorsport Culture & History

No abstract provided.

Primary Care Physician Supply And Population Health Outcomes In Florida, 2010-2019, Maxwell E. Droznin, Julia Fashner

HCA Healthcare Journal of Medicine

Background

Primary care physicians play vital roles in the prevention and management of chronic disease. With increasing rates of chronic disease and a national primary care physician shortage, the role that primary care physician supply has on health outcomes in Florida is not well understood. The objective of this study was to investigate the relationship between primary care physician supply (PCPS) and population health outcomes of obesity, life expectancy, coronary artery disease hospitalization, and death rate as reported by county in the state of Florida for the years 2010, 2013, 2016, and 2019.

Methods

This was a retrospective, cross-sectional study. …

U. S. Experiment Station Near Vicksburg, Mississippi

Southwest Mississippi Region

This postcard features a color illustration of an aerial view of the United States Waterways Experiment Station, a series of buildings and other structures, streets, and trees. The title is printed in the upper right of the card and the location is printed in the lower left edge.

U. S. Army Engineer Waterways Experiment Station Reservation Laboratory Complex Entrance, Vicksburg, Mississippi

Southwest Mississippi Region

This postcard features the main entrance to the reservation laboratory complex of the U. S. Army Engineer Waterways Experiment Station, a driveway divided by a median bearing the sign for the facility . A long, tan, brick building with eight brick columns across the front is pictured behind the driveway. A large tree is on the left end of the building, a flagpole with the United States flag stands in the middle in front of the building and trees are seen behind the building. A paragraph on the back of the card states "U. S. Army Engineer Waterways Experiment Station, …

Scale Model Of Niagara Falls, Waterways Experiment Station, Corps Of Engineers, U. S. Army, Vicksburg, Mississippi

Southwest Mississippi Region

This postcard features a color image of two women seated while observing a scale model of Niagara Falls. The woman on the left is wearing a dark dress and holding a rod out toward the model and the woman on the right is wearing a red dress. The back of the card contains the following information: "Waterway Experiment Station, Corps of Engineers, U. S. Army, Vicksburg, Mississippi...Showing a scale model of Niagara Falls, constructed for test purposes. Open daily to the public Monday through Friday, with free guided tours at 10 a.m. and 2 p.m."

Mississippi River Scale Model, Waterways Experiment Station, Corps Of Engineers, U. S. Army, Vicksburg, Mississippi

Southwest Mississippi Region

This postcard features a color image of two women and one man observing the Mississippi River flood control model at the Waterways Experiment Station, Corps of Engineers, U. S. Army, in Vicksburg, Mississippi. One woman is wearing a bright red dress and the other woman is wearing a black dress. The man is wearing a white shirt and gray pants. A line of white structures is pictured behind the model. Signs for "Grants Canal" and "Delta, LA "are shown within the model. The back of the card includes the following information: "Waterway Experiment Station, Corps of Engineers, U. S. Army, …

Mississippi River Flood Control Model, Waterways Experiment Station, Corps Of Engineers, U. S. Army, Vicksburg, Mississippi

Southwest Mississippi Region

This postcard features a color image of two women observing the Mississippi River flood control model at the Waterways Experiment Station, Corps of Engineers, U. S. Army, in Vicksburg, Mississippi. One woman is wearing a bright red dress and the other woman is wearing a black dress. A blue car is pictured parked on the street near the model and a small white structure is to the left behind the model. The back of the card includes the following information: "Waterway Experiment Station, Corps of Engineers, U. S. Army, Vicksburg, Mississippi...Showing a section of the Mississippi River flood control model. …

Air View Of The Masonite Plant, Laurel, Mississippi

Pine Belt Region

This postcard features a color illustration of the Masonite (engineered wood) plant in Laurel, Mississippi, a series of buildings beside a small body of water. A water tower is near the water and a steam or smoke is billowing from a nearby smoke stack. A field of trees is seen on the other side of the water. The title of the card is printed along the top of the image.

Winning Back Attendance: Effects Of Winning Performance, Online Search, And The Mlb Rule Changes For More Dynamic Games, Rhino Kim, Sue Ryung Chang

Asia Marketing Journal

As Major League Baseball (MLB)’s continuous decline in popularity has caused its game attendance to drop gradually, the league makes a desperate attempt such as game rule changes to remain relevant. Along with the introduction of new rules to make games more dynamic such as the pitch clock, bigger bases, and defensive shift limitations, it is important for MLB franchises to understand drivers for game attendance. We focus on the effect of accumulated winning performance of the two teams on game attendance, one of the key drivers of game attendance, and investigate how it is influenced by consumer and industry …

Generative Ai Based Adaptive Welcome Messages For Business Chat, Ashish Duggal, Sophie Shen, Jp Suh, Frank Vanzile, Ben Welch, Eunju Tae, Bryant Nguyen, Geoff Cox

Defensive Publications Series

Chats with a business entity typically include a welcome message that introduces the entity and sets the tone for the conversation. A well-written welcome message can improve customer satisfaction and can lead to improved outcomes such as higher sales. However, drafting customized welcome messages on an ongoing basis can be time consuming and is a creative challenge. This disclosure describes techniques to automatically generate suggestions for welcome messages using suitable artificial intelligence techniques, such as generative AI models. The generated suggestions are presented to entities such as businesses/merchants that implement online chat functionality. The suggestions are customized for each entity …