Digital Commons Network^™

Loss Of The Methylarginine Reader Function Of Snd1 Confers Resistance To Hepatocellular Carcinoma, Tanner Wright, Yalong Wang, Sabrina A Stratton, Manu Sebastian, Bin Liu, Mark T Bedford

Faculty, Staff and Student Publications

Staphylococcal nuclease Tudor domain containing 1 (SND1) protein is an oncogene that 'reads' methylarginine marks through its Tudor domain. Specifically, it recognizes methylation marks deposited by protein arginine methyltransferase 5 (PRMT5), which is also known to promote tumorigenesis. Although SND1 can drive hepatocellular carcinoma (HCC), it is unclear whether the SND1 Tudor domain is needed to promote HCC. We sought to identify the biological role of the SND1 Tudor domain in normal and tumorigenic settings by developing two genetically engineered SND1 mouse models, an Snd1 knockout (Snd1 KO) and an Snd1 Tudor domain-mutated (Snd1 KI) mouse, whose mutant SND1 can …

Blobcut: A Contrastive Learning Method To Support Small Blob Detection In Medical Imaging, Teng Li, Yanzhe Xu, Teresa Wu, Jennifer R Charlton, Kevin M Bennett, Firas Al-Hindawi

2020-Current year OA Pubs

Medical imaging-based biomarkers derived from small objects (e.g., cell nuclei) play a crucial role in medical applications. However, detecting and segmenting small objects (a.k.a. blobs) remains a challenging task. In this research, we propose a novel 3D small blob detector called BlobCUT. BlobCUT is an unpaired image-to-image (I2I) translation model that falls under the Contrastive Unpaired Translation paradigm. It employs a blob synthesis module to generate synthetic 3D blobs with corresponding masks. This is incorporated into the iterative model training as the ground truth. The I2I translation process is designed with two constraints: (1) a convexity consistency constraint that relies …

Robust Zero Modes In Non-Hermitian Systems Without Global Symmetries, Jose D. H. Rivero, Courtney Fleming, Bingkun Qi, Liang Feng, Li Ge

Publications and Research

We present an approach to achieve zero modes in lattice models that do not rely on any symmetry or topology of the bulk, which are robust against disorder in the bulk of any type and strength. Such symmetry-free zero modes (SFZMs) are formed by attaching a single site or small cluster with zero mode(s) to the bulk, which serves as the “nucleus” that expands to the entire lattice. We identify the requirements on the couplings between this boundary and the bulk, which reveals that this approach is intrinsically non-Hermitian. We then provide several examples with either an arbitrary or structured …

Functional Analysis Of Recurrent Cdc20 Promoter Variants In Human Melanoma, Paula M Godoy, Abimbola Oyedeji, Jacqueline L Mudd, Vasilios A Morikis, Anna P Zarov, Gregory D Longmore, Ryan C Fields, Charles K Kaufman

2020-Current year OA Pubs

Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks. Melanoma is heavily burdened by non-coding variants, representing over 99% of total genetic variation, including the well-characterized TERT promoter mutation. However, the compendium of regulatory non-coding variants is likely still functionally under-characterized. We developed a pipeline to identify hotspots, i.e. recurrently mutated regions, in melanoma containing putatively functional non-coding somatic variants that are located within predicted melanoma-specific regulatory regions. We identified hundreds of statistically significant hotspots, including the hotspot containing the TERT promoter variants, …

Study Of Radon Concentrations In Some Of Public Ground Water Wells, Sana'a - Yemen, Ahmed Khalid Abdul-Rahim, Najwa Ahmed Al-Maqtari

Hadhramout University Journal of Natural & Applied Sciences

This study aims to assess radon-222 concentration levels in public ground water wells in Sana'a city, Yemen. Forty-three well water samples were collected from the study area. The alpha spectroscopy method was used to measure the samples using a RAD7 detector. The radon concentrations were in the range from 0.82 ± 0.38 Bq/L to 38.73 ± 2.98 Bq/L. A moderate correlation of radon levels with aquifer type was observed. Also, weak correlations of radon levels with electric conductivity, pH, and temperature, and no correlation with measured heavy metals were observed. Annual effective dose rates () were calculated and were found …

Urgensi Perlindungan Data Pribadi Pada Sistem Elektronik Untuk Anak Di Bawah Umur Di Indonesia Serta Perbandingan Regulasi Dengan Uni Eropa (General Data Protection Regulation), Dzikrina Laili Kusumadewi, Akhmad Budi Cahyono

Lex Patrimonium

Childrens are inseparable from using technology. Using this technology also has a negative impact, which is misuse of one's personal data. This threat is quite troublesome, especially for children, in the eyes of the law, that are considered as incompetent individuals. Unfortunately, Regulation Number 27/2022 concerning Personal Data Protection does not regulate and explain in detail the protections that children can get for the security of their personal data. Therefore, this research will discuss child regulations, sanctions, and compensation in protecting personal data; child rights provisions; and the comparison. The aim is to provide an explanation of what provisions have …

Spatial And Temporal Variations Of Microplastics Within Humboldt Bay, California, Isabelle M. Marcus, Tamara B. Barriquand, Rebecca M. Thompson, Bennett C. Hosselkus, Cole T. Hutson, Michael Jacobs, Connor Mcneil, Leah Newton, Stephanie M. Olivarez, Jeffrey Abell

CSU Journal of Sustainability and Climate Change

This study aimed to quantify microplastic (MP) concentration and analyze the spatial and temporal variabilities of the concentrations during the tidal cycle in Humboldt Bay, California. To get an approximation of MP concentration, both water and sediment samples were taken at five different stations, twice during one tidal cycle. Sampling was conducted during two different cruises, on the 19th and 21st of September 2020. The samples were processed in the lab using a density separation procedure and filtration. MP concentrations in the different samples were determined using an average optical microscopy count. Comparison of the water column MP concentrations during …

Science And Solutions For A Warming World, Kim Cobb

Sustainability Seminar Series

Kim Cobb, Director, Institute at Brown for Environment and Society and Professor, Dept of Earth, Environmental, and Planetary Sciences & Environment and Society, Brown University, presents this week's seminar.

The Negative Stigma Surrounding Mathematics, Marissa A. Greisen

PSU McNair Scholars Online Journal

There is a negative stigma that surrounds mathematics in our education system. It is important to bring notice to this for the benefit of future students. There is a lot of research claiming that math is looked down on, but they do not answer why, or what we can do to fix it. Why is there a greater negative stigma around math and not other subjects? What roles to teachers, parents, and peers play in this stigma? In this article, I created a survey for people to answer questions regarding their opinion on math, who they believe typically does well …

Contemporary Library Censorship Tactics: Reviewing The Literature, Lex Faller

PSU McNair Scholars Online Journal

Library censorship efforts in the U.S. have broken records annually since 2021, spurred by social, technological, and political developments. These censorship efforts most frequently target diverse media representing Black, Indigenous, and people of color (BIPOC) and/or lesbian, gay, bisexual+, trans+, queer, intersex, and asexual+ (LGBTQIA+) communities in and at libraries. The current surge in attempts to censor library materials constitutes part of a greater conservative political strategy in the contemporary culture wars. This literature review analyzes the academic and professional literature alongside the gray literature regarding these censorship efforts to make sense of these trends. By investigating bodies of knowledge …

E-Vehicles Emergency Volumetric Flow Pump With Wheel Speed/E-Machine Speed For Towing Function, Konrad Hirschbeck

Defensive Publications Series

No abstract provided.

Continual Learning System With Sentence Embeddings, Anonymous

Defensive Publications Series

Recent improvements in computing power and ambient technologies have opened up new perspectives in ambient intelligence and proactive software systems. The need emerges for an ambient and supportive system that deeply understands the user's needs and preferences under the current context. In this work, we propose a recommendation system that aggregates and understands the current situation and continuously learns from the user’s decision history. To leverage a rich pool of contextual data, the system dynamically changes the strategy and scope for contextualization and encodes multimodal data into unified embeddings. A contextual similarity database consisting of these embeddings is leveraged for …

The Level Of Job Security Among Public School Teachers In The Bani Obaid District, Raya Gharram, Nouwar Al-Hamad

Jordan Journal of Applied Science-Humanities Series

This study aimed to identify the level of job security among public school teachers in the Bani Obeid District from their perspective. The descriptive survey method was utilized due to its relevance to the study's objectives, and a sample of 357 male and female teachers was chosen using the simple random method. To achieve the study's objectives, a questionnaire consisting of 24 items was developed to measure the level of job security among teachers. The results indicated that the level of job security for public school teachers in the Bani Obeid District was high. Additionally, the results showed no statistically …

The Degree Of Using Cloud Computing Applications In The E-Learning Environment And Its Obstacles For Secondary School Students In The Capital Amman Governorate From The Viewpoint Of Their Teachers, Rehab Ibrahim, Fawaz Shehadeh

Jordan Journal of Applied Science-Humanities Series

This study aimed to reveal the extent of cloud computing application usage in the e-learning environment and the obstacles faced by secondary school students in the Capital Governorate of Amman from the perspective of their teachers. The study adopted a descriptive survey method, and a questionnaire, comprising 30 items, was developed to collect data. This questionnaire consisted of two parts: the first to measure the extent of cloud computing application usage in the e-learning environment for secondary school students in the Amman governorate, and the second to identify obstacles related to cloud computing applications in the e-learning environment. The validity …

The Effect Of Employing Artificial Intelligence Tools In Dry Laboratories On Laboratory Performance Skills And Anxiety Levels From The Perspective Of Secondary School Students, Osamah Al-Dalalah

Jordan Journal of Applied Science-Humanities Series

This study aimed to identify the effect of employing artificial intelligence tools in dry laboratories on laboratory performance skills and anxiety levels from the perspective of secondary school students. The study sample consisted of 104 secondary school students in Madinah, and it included two types of variables: An independent variable, which is the use of artificial intelligence tools in dry laboratories, and dependent variables, which are laboratory performance skills and laboratory performance anxiety. The results showed a significant impact of employing artificial intelligence tools in dry laboratories on developing laboratory performance skills and reducing the level of laboratory performance anxiety. …

Offenseval 2023: Offensive Language Identification In The Age Of Large Language Models, Marcos Zampieri, Sara Rosenthal, Preslav Nakov, Alphaeus Dmonte, Tharindu Ranasinghe

Natural Language Processing Faculty Publications

The OffensEval shared tasks organized as part of SemEval-2019-2020 were very popular, attracting over 1300 participating teams. The two editions of the shared task helped advance the state of the art in offensive language identification by providing the community with benchmark datasets in Arabic, Danish, English, Greek, and Turkish. The datasets were annotated using the OLID hierarchical taxonomy, which since then has become the de facto standard in general offensive language identification research and was widely used beyond OffensEval. We present a survey of OffensEval and related competitions, and we discuss the main lessons learned. We further evaluate the performance …

Chapin Church Council Minutes 2014, Chapin United Methodist Church

Methodist Local Church Records

No abstract provided.

Chapin Church Council Minutes 2015, Chapin United Methodist Church

Methodist Local Church Records

No abstract provided.

Chapin Church Council Minutes 2016, Chapin United Methodist Church

Methodist Local Church Records

No abstract provided.

Spartan Daily, November 28, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 161, Issue 40

Cover And Contents

Turkish Journal of Earth Sciences

No abstract provided.

Closing The Gap: Leveraging Aes-Ni To Balance Adversarial Advantage And Honest User Performance In Argon2i, Nicholas Harrell, Nathaniel Krakauer

CERIAS Technical Reports

The challenge of providing data privacy and integrity while maintaining efficient performance for honest users is a persistent concern in cryptography. Attackers exploit advances in parallel hardware and custom circuit hardware to gain an advantage over regular users. One such method is the use of Application-Specific Integrated Circuits (ASICs) to optimize key derivation function (KDF) algorithms, giving adversaries a significant advantage in password guessing and recovery attacks. Other examples include using graphical processing units (GPUs) and field programmable gate arrays (FPGAs). We propose a focused approach to close the gap between adversarial advantage and honest user performance by leveraging the …

Vaccination Status, Views, And Opinions On The Covid-19 Vaccine, Zuri Dale

COVID Research

The Spring 2023 Tigers Care Vaccination Status and Views/Opinion Survey sought to capture perspectives on COVID-19 vaccination within the Texas Southern University community during spring festivities, engaging 126 respondents. Findings revealed that 86.29% were fully vaccinated, predominantly with the Pfizer vaccine. Among respondents, 78% had received a booster, and 42% expressed willingness to get a new booster in 2023.

Hesitancy was reported by 40% of participants, driven by concerns about long-term effects and vaccine safety. Factors like medical consultations and research helped change minds among hesitant individuals. A small segment (9.68%) remained unvaccinated, largely citing personal choice or distrust in …

Improving Shallow Water Nautical Charts Via Operational Automated Machine Learning-Based Bathymetry Extraction From Airborne Lidar Point Clouds, Kim Lowell, Brian Miles

Center for Coastal and Ocean Mapping

A proof-of-concept clustering-based approach to automatically extracting shallow water bathymetric soundings from airborne LiDAR point clouds has been converted to software-engineered code and continues to evolve. This has brought enhancements including the conversion of extracted bathymetric soundings to area-based maps. The original testbed was 2016 500m-by-500m NOAA LiDAR tiles near Key West, Florida; currently being evaluated are 2022 tiles north of Miami Beach. Accuracy evaluation for the two data sets suggest the clustering approach is instrument-neutral, readily adaptable, and requires minimal human intervention. The analytical approach that couples a widely used approach used for sonar data (CHRT – “Cube with …

The Geo/Thermochronology Of Dismal Island (Marguerite Bay, Antarctic Peninsula), Fati̇h Karaoğlan, Burcu Karataş, Yavuz Özdemi̇r, Erhan Gülyüz, Oleg Vassilev, Mahmut Oğuz Selbesoğlu, Semi̇h Gi̇ldi̇r

Turkish Journal of Earth Sciences

Dismal Island is located at the entrance of Marguerite Bay between Adelaide Island to the northeast and Alexander Island to the southwest within the Antarctic Peninsula (AP). Its unique position between Alexander and Adelaide islands provides the opportunity to perform testing and link these regions through Cenozoic magmatism and tectonics due to the subduction of the Pacific plate beneath the AP along the northern margin. Dismal Island was visited in February 2021 within the framework of the sixth Turkish Antarctic Expedition (TAE-VI). Thirteen samples were collected for petrography, geochronology, and low-temperature thermochronology (LTT). Of the samples, 3 were dated using …

November 28, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Applicability Of Real-Time Ppp Technique In Polar Regions As An Accurate And Efficient Real-Time Positioning System, Reha Meti̇n Alkan, Serdar Erol, Bi̇lal Mutlu

Turkish Journal of Earth Sciences

The polar regions, which include the Arctic and Antarctic areas, attract the attention of people every day, and issues that are closely related to the future of humanity make these regions even more important. Accurate and reliable positioning in polar regions is very critical for scientific research projects and also for commercial, touristic, and other human activities. In this study, the usability and the accuracy performance of the real-time precise point positioning (RT-PPP) technique in high-latitude polar regions with harsh environmental and extreme atmospheric conditions were investigated. Within that framework, the GNSS dataset of six IGS multi-GNSS stations located at …

Webgis-Based Data Center Design For Polar Science Studies: Simulation Of Türkiye, Müge Şenel, Hasan Hakan Yavaşoğlu, Burcu Özsoy, Hi̇mmet Karaman, Mustafa Ümi̇t Gümüşay

Turkish Journal of Earth Sciences

Scientific studies concentrated in Antarctica hold great value and importance for humanity. Research projects are conducted in various disciplines on the continent, where nearly 100 research stations from 30 countries are established. Despite the challenges posed by Antarctica's natural structure, unique environment, difficult working conditions, and limited logistics opportunities, scientific research conducted there is indispensable due to the valuable information it offers. In pursuit of accessing this information, Turkish Antarctic expeditions have been organized since 2017. In this study, a polar data center was established through a web-based geographic information system (WebGIS), a significant infrastructure for the continuity of scientific …

Equation-Based And Data-Driven Modeling: Open-Source Software Current State And Future Directions, Lagrande Gunnell, Bethany Nicholson, John Hedengren

Faculty Publications

A review of current trends in scientific computing reveals a broad shift to open-source and higher-level programming languages such as Python and growing career opportunities over the next decade. Open-source modeling tools accelerate innovation in equation-based and data-driven applications. Significant resources have been deployed to develop data-driven tools (PyTorch, TensorFlow, Scikit-learn) from tech companies that rely on machine learning services to meet business needs while keeping the foundational tools open. Open-source equation-based tools such as Pyomo, CasADi, Gekko, and JuMP are also gaining momentum according to user community and development pace metrics. Integration of data-driven and principles-based tools is emerging. …

Accuracy Assessment Of Glacier Depth Monitoring Based On Uav-Gpr On Horseshoe Island, Antarctica, Mahmut Oğuz Selbesoğlu, Mustafa Fahri̇ Karabulut, Özgün Oktar, Burak Akpinar, Oleg Vassilev, Mehmet Arkali, Şeyma Nur Tufan, Alptuğ Şeref Ayyildiz, Esra Günaydin, Ati̇lla Yilmaz, Doğaç Baybars Işiler, Burcu Özsoy

Turkish Journal of Earth Sciences

Unmanned aerial systems have a wide range of uses in studying the impacts of climate change over several fields. Recently, its combination with a ground-penetrating radar (GPR) technology has been demonstrated to be highly effective for surveying glaciers, especially in difficult and inaccessible terrains like Antarctica. In this context, this study focused on exploring the potential of using an unmanned aerial vehicle (UAV)-GPR to measure the depth of glaciers on Horseshoe Island, West Antarctica. The data were collected during the seventh Turkish Antarctic Expedition (TAE-VII) in February and March 2023, within the scope of the international project titled "Glacier monitoring …