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2023-12-01 Minutes & Appendices, Longwood University

1964-Present ~ Board of Visitors Meeting Minutes

No abstract provided.

Idasanutlin And Navitoclax Induce Synergistic Apoptotic Cell Death In T-Cell Acute Lymphoblastic Leukemia, Kimberly B Johansson, Megan S Zimmerman, Iryna V Dmytrenko, Feng Gao, Daniel C Link

2020-Current year OA Pubs

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy in which activating mutations in the Notch pathway are thought to contribute to transformation, in part, by activating c-Myc. Increased c-Myc expression induces oncogenic stress that can trigger apoptosis through the MDM2-p53 tumor suppressor pathway. Since the great majority of T-ALL cases carry inactivating mutations upstream in this pathway but maintain wildtype MDM2 and TP53, we hypothesized that T-ALL would be selectively sensitive to MDM2 inhibition. Treatment with idasanutlin, an MDM2 inhibitor, induced only modest apoptosis in T-ALL cells but upregulated the pro-apoptotic BH3 domain genes BAX and BBC3, prompting …

Development Of A Potassium Permanganate Catalyst-Infused Fuel Grain For Hydrogen Peroxide Hybrid Thruster Ignition Enhancement, Ryan J. Thibaudeau

All Graduate Theses and Dissertations, Fall 2023 to Present

This thesis describes and addresses the need for reliable ignition in small satellite hybrid propulsion systems using hydrogen peroxide. It describes process of creating custom 3D printed ABS plastic fuel grains with small amounts of catalysts. These catalysts lead to a more reliable and energy-efficient ignition of a hybrid rocked propulsion system using catalyst-infused ABS and high-test hydrogen peroxide (HTP). Hydrogen peroxide is a high-density oxidizer and therefore more volumetrically efficient for a small satellite using hybrid rocket technology when compared to gaseous oxygen (GOX). The traditional ignition methods of hybrid rocket propulsion systems using HTP are compared to and …

Impacts Of Area-Wide Air Pollution On Multimodal Traffic: Comparing Pedestrian, Motor Vehicle, And Transit Volumes In Utah, Prachanda Tiwari

All Graduate Theses and Dissertations, Fall 2023 to Present

The impact of area-wide air pollution on multimodal traffic volumes has been underexplored. Thus, this research investigates the effect of area-wide air pollution on pedestrian volumes, motor volumes, and transit ridership across two urban areas in Utah for two years (2018 and 2019). The research employed multilevel modeling to study this effect. The model results showed an overall decrease in pedestrian volumes in both study areas, while driving volumes saw both increases and decreases in different locations. Transit ridership saw an increase during days with moderate air quality in one particular study area. Median income, vehicle ownership, and higher street …

Subjective Wellbeing Of Undergraduate Engineering Students: A Mixed Methods Study, Muhammad Asghar

All Graduate Theses and Dissertations, Fall 2023 to Present

In higher education, the prevalence of mental health issues among students has raised concerns regarding their overall success and wellbeing. While existing research often focuses on identifying and addressing mental health problems, there is a lack of emphasis on understanding the positive contributors to students' mental health. In this study, I expand the concept of mental health beyond the absence of negative mental health states to include the presence of positive mental health aspects through the concept of Subjective Wellbeing (SWB) (feeling that your life is going well, not badly), of engineering undergraduate participants. Both qualitative and quantitative data were …

Comparing Scaling Approaches To Estimate Unimpaired Streamflow Timeseries And Seasonal Flow Metrics At Ungauged Streams, Karl Christensen

All Graduate Theses and Dissertations, Fall 2023 to Present

River ecosystems are controlled in part by natural variation in the flow regime and streamflow alterations that impair these natural variations often have negative impacts for aquatic species. Flow metrics describing attributes of the natural flow regime can inform environmental water management goals to maintain and restore river ecosystems by mirroring critical aspects of the natural flow regime. However, unimpaired daily streamflow data needed to calculate these flow metrics is not always readily available. Statistical scaling approaches present an opportunity to estimate unimpaired flow metrics at ungauged locations to better address environmental water management objectives. This study evaluates a suite …

Consensus Modeling As A Cultural Practice: A Case Study From A Seventh-Grade Science Classroom, Sara Louise Miconi Gailey

All Graduate Theses and Dissertations, Fall 2023 to Present

Recent reforms in science education aim to involve K-12 students in practices similar to those of professional scientists. These reforms promote student collaboration and science practices including developing models and engaging in scientific argumentation with evidence. Small group work in science classrooms has increased following the reforms. However, while small group collaboration has gained popularity, research suggests that it does not always lead to equitable participation. This qualitative case study uses discourse analysis to examine how two small groups of students in a seventh-grade science class develop consensus models of a phenomenon and how students are socialized to participate in …

Virtual Structures Based Autonomous Formation Flying Control For Small Satellites, Tyson K. Smith

All Graduate Theses and Dissertations, Fall 2023 to Present

Many space organizations have a growing need to fly several small satellites close together in order to collect and correlate data from different satellite sensors. To do this requires teams of engineers monitoring the satellites orbits and planning maneuvers for the satellites every time the satellite leaves its desired trajectory or formation. This task of maintaining the satellites orbits quickly becomes an arduous and expensive feat for satellite operations centers. This research develops and analyzes algorithms that allow satellites to autonomously control their orbit and formation without human intervention. This goal is accomplished by developing and evaluating a decentralized, optimization-based …

Understanding The Effects Of A Mobile Flow Visualization Learning Tool On Engineering Undergraduate Interest In Fluid Mechanics, Lori M. Openshaw

All Graduate Theses and Dissertations, Fall 2023 to Present

Fluid mechanics is a difficult engineering course that tends to act as a weed-out course for undergraduate students. Despite this, fluid mechanics is critical, with related careers in disciplines such as Mechanical, Aerospace, Civil, Environmental, Biological, Ocean, and Naval engineering. Within these fields, there is a lack of graduates with sufficient fluid mechanics knowledge to fill the available positions. One solution to this career pipeline is to increase student interest and understanding of fluid mechanics.

Efforts to make fluid mechanics more interesting and easily understood include curricular changes such as emphasizing historical aspects of fluids, computer simulations that model complex …

Quantifying The Effect Of Stable Stratification On Low-Reynolds Number Flow Past A Horizontal Cylinder, Holland Kartchner

All Graduate Theses and Dissertations, Fall 2023 to Present

In this research, we study the behavior of flow around a cylinder in the presence of stable stratification, which refers to variations in density throughout the fluid. This phenomenon is observed in natural and industrial settings. We use computer simulations to analyze how stratification affects the flow patterns created by the cylinder. Specifically, we investigate situations where the stratification is perpendicular to the flow direction, and the wake exhibits two-dimensional characteristics. We use spectral-element method based computational fluids dynamics to simulate the phenomena. During the simulations, we vary two important parameters: the Densimetric Froude Number (Fr) and the …

Effects Of Indole Derivative Idc16 On Cell Proliferation, Transfection, And Alternative Splicing In Production Of Lentiviral Vectors By Transient Co-Transfection, Nataly Mier

All Graduate Theses and Dissertations, Fall 2023 to Present

Viruses can efficiently introduce genetic material into a variety of cells through cell infection. Therefore, viral vectors, defined as virus-based gene delivery systems, effectively transfer functional gene constructs to target cells. Among different viral vectors, lentiviral vectors are of interest due to the advantages offered to research and therapeutic applications. Low productivity of lentiviral vectors in mammalian producer cells and high production cost, however, remain barriers to the vectors’ routinary use, particularly in clinical settings.

Since most lentiviral vectors are derived from human immunodeficiency virus type I, their genome has been engineered to increase safety. Nevertheless, modifications of the lentiviral …

Navigating Roadblocks In Utah's Path Towards Curbing Greenhouse Gas Emissions, Emily K. Fletcher

All Graduate Theses and Dissertations, Fall 2023 to Present

In places where discussions about climate change have become highly political and divided, community groups have attempted to connect rival political parties by focusing on improving air quality. This topic is often less politically charged. The effects of climate change have been disproportionately felt by marginalized communities around the world. In the west side of the Salt Lake Valley, many communities are more likely to experience the negative consequences of a drying lake, a problem that Utah and other regions are currently facing, compared to others in the valley. This research focuses on the individuals who have signed the Utah …

Restoration Strategies For Wetlands In The Arid West: Seeding And Planting Approaches For Lakeshore Ecosystems, Jes Braun

All Graduate Theses and Dissertations, Fall 2023 to Present

Wetlands are widely recognized for their valuable benefits such as providing habitat, improving water quality, and reducing the impacts of flooding. However, wetlands face threats from development, drought, and invasive species. This is particularly apparent in the arid west, where upstream water use and drought make water scarcer and contribute to dramatically changing water levels. Here, I investigated revegetation techniques for lakeshore wetlands, using Utah Lake as a case study. Although recent management efforts have minimized invasive Phragmites cover, the desired plant communities are not returning as quickly as needed, highlighting the need to research restoration techniques. Through my research, …

In-Situ Optical Measurements Of High Temperature Combustion Plumes, Cara Frischkorn

All Graduate Theses and Dissertations, Fall 2023 to Present

Rocket motors are critical to the human exploration of space and to the United States missile defense systems. The design and manufacturing of these motors requires extensive simulation and testing to assure the motors will perform as intended and to minimize safety risks. Taking data from inside the rocket motors during tests is extremely difficult due to the intense temperatures inside the motor as it burns; most instrumentation cannot survive in this environment. The research discussed in this thesis aims to develop an instrumentation system composed of a fiberoptic cable which conducts light from the interior of a rocket motor …

Analysis Of Student Behavior And Score Prediction In Assistments Online Learning, Aswani Yaramala

All Graduate Theses and Dissertations, Fall 2023 to Present

Understanding and analyzing student behavior is paramount in enhancing online learning, and this thesis delves into the subject by presenting an in-depth analysis of student behavior and score prediction in the ASSISTments online learning platform. We used data from the EDM Cup 2023 Kaggle Competition to answer four key questions. First, we explored how students seeking hints and explanations affect their performance in assignments, shedding light on the role of guidance in learning. Second, we looked at the connection between students mastering specific skills and their performance in related assignments, giving insights into the effectiveness of curriculum alignment. Third, we …

Solar Flare Prediction From Extremely Imbalanced Multivariate Time Series Data Using Minimally Random Convolutional Kernel Transform, Kartik Saini

All Graduate Theses and Dissertations, Fall 2023 to Present

Solar flares are characterized by sudden bursts of electromagnetic radiation from the Sun's surface, and caused by the changes in magnetic field states in solar active regions. Earth and its surrounding space environment can suffer from various negative impacts caused by solar flares ranging from electronic communication disruption to radiation exposure-based health risks to the astronauts. In this paper, we address the solar flare prediction problem from magnetic field parameter-based multivariate time series (MVTS) data using multiple state-of-the-art machine learning classifiers that include MINImally RandOm Convolutional KErnel Transform (MINIROCKET), Support Vector Machine (SVM), Canonical Interval Forest (CIF), Multiple Representations SEQuence …

Impact Of Moisture Content And Composition On Flow Properties Of Dairy Powders, Katelynn Palmer

All Graduate Theses and Dissertations, Fall 2023 to Present

Milk protein concentrate (MPC) and isolate (MPI), and milk permeate powder (MPP) are functional dairy powder products that are used in food applications worldwide. It is critical that environmental factors and physical powder characteristics during production and storage are controlled. When dairy powders are exposed to non-ideal conditions (high moisture, varying temperatures,) they can quickly become very sticky, and clumpy. When powders become sticky, their ability to easily flow is reduced. As a result, processing and storing the powders effectively and sustainably becomes very difficult.

In the first study, an analysis method was created to test the general flow behavior …

Designing And Studying Redox-Active Molecules For Energy Storage And Desalination, Wenda Wu

All Graduate Theses and Dissertations, Fall 2023 to Present

Since the fast growth of the global population, energy scarcity has become a new threat to modern society. Those commonly seen resources like fossil, coal, and natural gas are nonrenewable energies, which cannot be replenished by human-scale time. In contrast, wind, solar, and hydropower are the three main renewable green energies under development with great efforts around the world. However, the intermittent character of these powers raises a new question: how to store them properly on large scales? By 2021, more than 90% of the electricity storage was taken by Lithium-ion batteries (LIBs). The usage of lithium brings concerns about …

Understanding The Pizza Baking Properties Of Low Moisture Part Skim (Lmps) Mozzarella Cheese, Anjali Verma

All Graduate Theses and Dissertations, Fall 2023 to Present

Mozzarella cheese is expected to melt, stretch, release free oil and exhibit browning and blistering when baked on pizza. This research aimed to investigate the effects of different starter cultures (based on lactose and galactose utilizing ability) and calcium levels on the functionality of Mozzarella cheese when baked on pizza. Four combinations of starter cultures using S. thermophilus (STI 06)-control, Lac⁺ Gal⁺ L. helveticus (LH 32), and Lac^- Gal⁺ adjunct culture L. helveticus (LH 7995) were used to make the cheese samples. Various tests were conducted over a seven-week period to evaluate their baking properties. The …

The Private Pilot Check Ride: Applying The Spacing Effect Theory To Predict Time To Proficiency For The Practical Test, Michael Scott Harwin

Theses and Dissertations

This study examined the relationship between a set of targeted factors and the total flight time students needed to become ready to take the private pilot check ride. The study was grounded in Ebbinghaus’s (1885/1913/2013) forgetting curve theory and spacing effect, and Ausubel’s (1963) theory of meaningful learning. The research factors included (a) training time to proficiency, which represented the number of training days needed to become check-ride ready; (b) flight training program (Part 61 vs. Part 141); (c) organization offering the training program (2- or 4-year college/university vs. FBO); (d) scheduling policy (mandated vs. student-driven); and demographical variables, which …

Climate Change And The Shifting Geography Of Coral-Reef Development, Victor Rodriguez-Ruano

Theses and Dissertations

Coral-reef development is modulated by growth processes that deposit calcium carbonate onto the reef, such as calcification, and destructive processes that remove calcium carbonate from the reef, such as bioerosion. Wherever calcification rates exceed bioerosion rates, there is a net accretion of the reef through time, but where bioerosion rates exceed calcification rates, there is a net destruction of the reef through time. A reef’s framework is the legacy of the interaction of these processes throughout a reef’s history. Studying the fossil frameworks of reefs can shed light on the environmental factors that have controlled reef development in the past, …

Investigating The Effects Of Collagen Alignment And Tricalcium Phosphate Incorporation On Osteoblast Cell Response, Kathryn Elizabeth Bock

Theses and Dissertations

Every year, over 20 million people globally are affected by bone tissue loss due to disease or trauma. Bone tissue engineering (BTE) is touted as a promising approach to promote bone tissue repair and regeneration. In this realm, development of collagen-based scaffolds incorporated with a bioceramic is often attempted to generate tissue scaffolds that resemble the organic and inorganic composition of native bone. In addition, a variety of different collagen processing techniques have been employed to produce anisotropically aligned scaffolds that can provide the essential biochemical and structural cues to guide cell response. While there have been numerous studies on …

Viscosity Of Adsorbent Slurries For Washcoating Applications, Nitish Chauhan

Theses and Dissertations

The viscosity of adsorbent slurries is pivotal in understanding their rheological behavior, yet, the research on adsorbent slurry viscosity has been limited. This study addresses this gap by analyzing porous and non-porous solutes' behavior in solvents and then applying it to the washcoating adsorbents on ceramic substrates. By examining MIL-101 (Cr), glass beads, silica nanoparticles, and Titania, the study aims to comprehend the viscosity variations of each solute in the solvents, water and ethanol. A key observation from this study was the significant role of wetting in determining viscosity, as initial results found that MIL-101 (Cr) exhibited the highest viscosity …

Component Approach For A Combined Hurricane Wind And Rainwater Damage And Time Related Expenses Model In Mid/High-Rise Buildings, Zhuoxuan Wei

Theses and Dissertations

This dissertation focuses on mid/high-rise commercial residential buildings (MHRB) vulnerable to wind-driven rainwater ingress during hurricanes. The author developed the WHIP-MHRB model, a new probabilistic vulnerability model funded by the Wind Hazard Infrastructure Performance Center (WHIP-C). This model combines the estimates of rainwater ingress, distribution and propagation, and damage assessments, and time-related expenses (TRE) predictions for MHRB during hurricanes. Embedded within WHIP-MHRB is the WHIP-TRE model, which forecasts repair times, delay times, downtime, and recovery times post-hurricane explicitly.

Furthermore, taking advantage of the new model, this study presents two approaches to address the combined wind and rain vulnerabilities of MHRB …

Stability And Control Flight Testing Of A Modified Cessna 172, Tatiana Dirrigl Forbes

Theses and Dissertations

The Cessna 172N is a small, fixed-wing, single-engine aircraft. The modified Cessna 172N included a swapped engine to a Lycoming O-360-A4M, tuned exhaust, and variable timing ignition installed. Test flights on this aircraft were performed order to evaluate the stability and control characteristics of the Cessna 172N, and compare them with the regulations in the Title 14 CFR Part 23 Airworthiness Standards for Normal, Utility, Acrobatic, and Commuter Category Airplanes. The flight test consisted of four separate tests performed during a single flight, departing from and returning to Melbourne Orlando International airport (KMLB). The data was collected through static and …

Stochastic Optimal Control Of Conditional Mckean-Vlasov Equations With Jump And Markovian Switching, Charles Samuel Conly Sharp

Theses and Dissertations

This thesis obtains a number of results in stochastic optimal control for conditional McKean-Vlasov equations with jump and Markovian switching. First, we prove the uniqueness of the solutions and derive a relevant version of Itô's formula. We provide the dynamic programming principle and prove the associated verification theorem. A stochastic maximum principle is established. Further, we derive the relationship between dynamic programming and the stochastic maximum principle. Additionally, we utilize our stochastic maximum principle result for a mean-variance portfolio selection problem.

Development Of A Physics-Informed Neural Network For Prediction Of Blood Flow, Marcello Vittorio Mattei Di Eugenio

Theses and Dissertations

Abstract—Objective: We propose a new neural network architecture that accepts point clouds and outputs 3D velocity profiles for aneurysm geometries. Methods: We generated a synthetic aneurysm 3D flow dataset using CFD and used it to train our model architecture and compare it with other popular architectures like U-net and PointNet. We incorporate tools for improving model performance such as incorporating a distance function, a physics-informed loss to enforce the law of mass conservation, and the Huber loss to learn patterns across heterogeneous velocity components of multiple dimensions. Results: The tools implemented together with our architecture achieved the best performance on …

Design Space Visualization And Exploration For Many Goal Problems Under Uncertainity, Niharika Balaji

Theses and Dissertations

ABSTRACT

Designing a complex engineered system is challenging due to many conflicting goals, uncertainties, and multiple interactions. Traditional optimization approaches often yield single-point solutions, which may not be suitable for early design stages due to their susceptibility to changes in conditions and uncertainties. To address this challenge, a satisficing approach is employed. This approach enables designers to effectively navigate the design space and identify satisficing solutions that balance conflicting goals in the face of uncertainties and changes in conditions. From a systems design perspective, we view design as an iterative process that involves making informed decisions based on available information …

The Relationship Between Biofouling Adhesion And Frequency Of Mechanical Cleaning To Control The Recruitment To Clear Coatings, Dylan Thomas Eggers

Theses and Dissertations

There is a need to control biofouling on sensors and transparent windows in the marine environment. Clear silicone coatings offer a method to reduce the adhesion strength of marine organisms to the surface, however, these also require mechanical cleaning to maintain the surfaces free of fouling. This research evaluated the performance of eighty seven formulations and took the top two candidates to investigate a) the frequencies of wiping required by a brush to maintain two coatings and uncoated glass surfaces free of fouling and b) the effects of clear silicone coatings fouling release properties on required frequencies. The panels were …

Underwater Image Enhancement: A Pipeline For Underwater Computer Visions, Humberto Lebron Rivera

Theses and Dissertations

Ocean exploration has surged in popularity and significance in recent years, including diverse areas like maritime archeology, underwater resources, and submerged structure inspection. The activities mentioned above heavily depend on vision and imagery, a challenge in the unpredictable marine world. This thesis presents a conditional generative adversarial network model for image-to-image translation problems. We designed and trained the model with the end goal of enhancing underwater images. Five metrics were employed for validation to quantify our model’s resulting enhanced images. By doing so, we aim to establish a pipeline that can leverage aerial computer vision algorithms for marine applications.

Our …