Digital Commons Network^™

Solar-Powered Microgrids In Northern California: An Opportunity For Resilience, Marina Riddle

Master's Projects and Capstones

Planned and unplanned power outages have been increasing in frequency and duration, negatively impacting all public sectors, and threatening public safety. These outages are deadly to those who rely on medical devices. As climate change-fueled extreme weather events (wildfires, earthquakes, storms, etc.) also increase in frequency, our electrical grid must be prepared to bounce back. Microgrids provide necessary redundancy and reliability. Through a novel GIS suitability analysis, based on solar radiation, land use type, local energy demand, distance to transmission lines, distance to roads, and slope, optimal locations for solar-powered microgrids throughout Northern California were determined. The counties of Fresno, …

Does Probiotic Supplementation Help Decrease Symptoms In Adults Previously Diagnosed With Major Depressive Disorder?, Alexa Hammock, Hayley Loiselle

Physician Assistant Capstones, 2020-current

Objective: To assess the effect of probiotic supplementation on clinical symptoms of major depressive disorder in adults. Design: Systematic literature review. Methods: Searches were performed on PubMed using the terms “adults with depression and probiotics”. The limits on PubMed were set to include randomized control trials, studies on adults, studies done within the last 10 years, studies done on patients that did not have depression, studies that did not use the Beck Depression Inventory, and studies that focused on other conditions. Results: Three studies were found that met search criteria: Reninghaus et al., Schaub et al., and Chahwan et al. …

Organic Dining Behaviour In British Restaurants, Lokman Dinc, Rong Huang

Plymouth Business School

The organic food market has experienced significant growth in recent decades all over the world. Within the context of the UK, a remarkable rise can be seen considering the recent popularisation of organic food products. With these trends in mind, the aim of this research is to develop better understanding of organic dining behaviour in British restaurants. To achieve this aim, this research used questionnaire technique and analyse the data using SEM.The key findings of the research confirmed that a range of factors, including advertisements through social media, knowledge, price, taste, quality, availability, and labelling, all significantly influence consumer intention …

Tipping The Mesoscales: Advances In Multipeak Bragg Coherent Diffraction Imaging, J. Nicholas Porter

Theses and Dissertations

Material failure begins with strain between atoms and cascades upward into macroscopic damage such as cracks. Therefore, our ability to predict (and therefore prevent) material failure is largely limited by our understanding of this process. This understanding, however, has been impeded by the difficulty of directly observing such phenomena. In this thesis, I discuss recent advances in Bragg coherent diffraction imaging (BCDI) which produce three-dimensional, mesoscopic images of interior strain in microcrystals. In particular, I present a novel algorithm, based on the concept of cyclic-constrained optimization (CCO), for the rapid, coupled reconstruction of a microcrystal from multiple Bragg diffraction patterns. …

Fabrication And Characterization Of Flexible Microelectrode Arrays On Kapton Polyimide For Implantable Spinal Cord Stimulation Applications, Nabil Jamhour

Theses and Dissertations

Recent advances in spinal cord stimulation (SCS) technology have made a significant impact in the treatment of chronic pain which is a prevalent issue amongst 20% of the population in developed nations. A few medical device manufactures have developed SCS devices that have been studied in clinical environments and reported to be effective and safe for commercial use. However, the current SCS devices available are bulky, rigid, and still present infection, fibrosis, discomfort, pulse delivery challenges and other concerns for patients. In this study, flexible electrodes processed on Kapton® polyimide films by physical vapor and inkjet deposition are fabricated and …

Students’ Perception Of Possibilities Of Using Business Process Modeling To Improve Organizations, Małgorzata Oleś-Filiks

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: The main aim of this article is to analyze the knowledge of the students – future users of these systems – of the awareness of the use and possibilities of using business process modeling in improving the organization. Design/Methodology/Approach: The research was carried out using the CAWI method. The questionnaire prepared for this purpose was first verified with the participation of experts in the field of business process modeling and then made available to students to fill in on the servers of the Faculty of Management of the University of Warsaw. The study concerned general knowledge of concepts related …

Optimizing Sepsis Management Through Enhanced Protocol Compliance In The Emergency Department, Oscar J. Castillo

Master's Projects and Capstones

Problem: The Quality Improvement (QI) Project focused on improving early sepsis management and sepsis bundle adherence among Emergency Department (ED) nurses to decrease sepsis mortality rates and avoidable length of hospital stays (LOS).

Context: A group of Clinical Nurse Leaders (CNL) students evaluated sepsis protocol compliance at Hospital A's ED, which provides critical care for patients with various medical conditions. The CNL students concentrated on patients identified with sepsis for the QI Project.

Interventions: Limitations and time did not allow for the implementation of interventions. Recommendations offered to management included increasing sepsis training biannually and intravenous placement skills, offering sepsis …

Limiting Privilege: Upward Mobility Within Higher Education In Socialist Poland, Agata Zysiak

Central European Studies

State socialism tried to industrialize, urbanize, encourage the more frequent washing of hands, urge people to leave the church, emancipate women, and electrify cities—all within a single lifetime. Central to these initiatives was extending educational opportunities to the working class and creating a vision of an egalitarian socialist university that offered advancement for all. Limiting Privilege: Upward Mobility Within Higher Education in Socialist Poland traces the possibilities and limits of this goal by looking at a model socialist university established in 1945 in the working-class city of Łódź, Poland. Initially a flagship project of socialist modernization, the university tried to …

Personal Leadership Development Plan, Tristan Parker

Mechanical Engineering and Materials Science Independent Study

If there is one thing I have learned this semester from this course, it's that typing someone’s personality based on a limited amount of characteristics or somewhat abstract qualities is tough! This is true even when typing oneself, as I feel like my feelings or attitudes towards the world are constantly changing. Considering this, I tend to place more merit in long-term habits or qualities that shape who a person is. Based on my personal experience, I would type myself on the Myers-Briggs Chart as an ISTP, or the Virtuoso.

An Empirical Study Of Machine Learning Techniques For Accurate Stock Price Forecasting, Daniel Paliulis, Hari Patchigolla

Honors Scholar Theses

This paper presents a comprehensive approach to predicting future stock prices of companies using machine learning and time series analysis. The research problem is centered around addressing the complexity and emotion-driven nature of stock investment decisions. To create an objective determinant in stock decisions, we propose a machine learning model utilizing time series data from major companies, including Amazon, Apple, Google, Nvidia, Meta, Tesla, Salesforce, Intel, and Microsoft. We explore the use of Long Short-Term Memory (LSTM) neural networks, to capture the temporal dynamics of stock prices. These models are designed to process sequential data, maintaining short term and long …

Assessing Leadership In Business: A Critical Investigation Of Mary Barra, Krisha Patel

Honors Scholar Theses

Understanding what makes a good leader is a topic of ongoing interest in the practice of business. Research to-date has distinguished between being a manager and being a leader and also has established a set of principles to consider in assessing leadership. In this thesis, I draw upon principles of leadership, including emotional intelligence; vision creation; inspiring others; leading in good and difficult times; fostering, developing, and recognizing others; and creating a winning culture to offer a critical assessment of Mary Barra as a leader within the business arena.

Using A Three-Dimensional Theoretical Orientation Matching Model To Predict Therapeutic Outcomes, Daniel Rhodes

Electronic Theses and Dissertations

Matching helpers and clients in a therapeutic setting is inefficient and ineffective. So far, there are no significant and enduring variables that reliably match helpers and clients that lead to positive therapeutic outcomes. This study attempts to match helper and client using theoretical orientation. It uses a quantitative methodology to predict therapeutic outcomes given match quality in the therapeutic dyad. Participants were 30 dyadic pairs—consisting of one helper and one client—who had a pre-existing therapeutic relationship. Each was given an assessment tool, used to measure their theoretical orientation to psychotherapy. Results showed no statistically significant relationships between theoretical orientation match …

Interactive Effects Of Sublethal Concentrations Of Fracking Biocides And Abandoned Mine Drainage On Amphipod Behavior, Kelly Lenhart

Electronic Theses and Dissertations

This thesis examined the sublethal effects of three pollutants, namely glutaraldehyde, 4,4-dimethyloxazolidine (DMO), and abandoned mine drainage (AMD), on amphipods. The primary objective was to investigate their combined effects on amphipods. The three pollutants, despite having the potential to combine in the environment, have not been studied to determine their potential for detrimental interactive effects which could result in unexpected environmental damage.

The research employed a series of experimental setups involving controlled exposure of amphipods to varying, putatively sublethal, concentrations of the chemicals of interest. Subsequently, effects were assessed via both behavioral and feeding assessments. To facilitate this analysis, novel …

Air-Jet Bioprinting Of Stem Cell-Encapsulated Alginate Micro-Droplets For Organoid Biomanufacturing, Mirabella B. Stump

Electronic Theses and Dissertations

Biomanufactured 3D-organoids show promise for modeling and treating various conditions, particularly insulin-dependent diabetes mellitus (type-1 diabetes). Pancreatic islet organoids serve as sustainable sources of insulin-producing β-cells, potentially restoring insulin regulation in patients and providing a long-term solution for diabetes. Hydrogel droplet printing is an emerging technique in regenerative medicine due to its advantageous tunability and biocompatibility; however, challenges of consistency, quality control, and scalability persist. To address these issues, we developed a novel air-jetting based droplet bioprinting system for the generation of monodispersed alginate micro-droplets. The objective of this project was to incorporate human induced pluripotent stem cells (hiPSCs) into …

Large - Scale Manufacturing Of Fluorescent Perfluorocarbon Nanoemulsions For Oxygen Delivery, Anneliese Troidle

Electronic Theses and Dissertations

Over 100,000 Americans are currently waiting for a life – saving organ transplant, yet 17 patients die daily waiting for a transplant they will never receive [1]. Preservation of organs is an area that has seen innovation throughout the years and can improve rates of transplantation, yet vascularized composite allotransplantation preservation has not followed suit [2]. Current standard of care is use of electrolyte solutions such as Histidine – Tryptophan – Ketoglutarate (HTK) or University of Wisconsin (UW) Solution, yet these perfusates lack an oxygen carrying component [3]. Hemoglobin – based oxygen carriers (HBOCs) …

Retreat Village Design In Letchworth State Park Region: An Architecture Development In A Highly Valued State Park Meets The Triple Bottom Line Of Sustainability, Jing Hua

Theses

Letchworth State Park, located in Livingston and Wyoming counties, New York, renowned as the “Grand Canyon of the East”, is one of the most scenically magnificent areas in the eastern United States. However, there are no well-developed leisure centers around or in the park. The lack of good accommodations, in contrast to the availability of restaurants with local character, leisure activities, and other supporting facilities in the area, fails to fully achieve the development potential of the natural scenery of the region. This thesis demonstrates that a retreat complex village that brings people closer to the natural landscape of Letchworth …

Evaluating The Impact Of Biosimilars In The Drug Market, Olivia Sitter

Theses

Drug pricing has increase to the point where many Americans are unable to afford prescriptions for both long- and short-term diseases. Within the last decade, U.S lawmakers have changed legislation so that biosimilars can be added into the drug market in hopes of creating affordable products. Biosimilars allow more options for consumers and add increased competition for manufactures which should decrease the overall price of the original biopharmaceutical the biosimilar is modeled after. In current research, the impact of biosimilars within the European Union has been investigated heavily, but the US approved biosimilars much later and there is less information …

Robochurch: Baptizing Bots And Sanctifying Silicon?, Peter Bellini

Witness

No abstract provided.

Galonsky V. East 17th Llc

All Decisions

No abstract provided.

Top Tips For Effective Use Of Periodontal Instruments In Primary Care, Morag Powell, Ruth Potterton, Ewen Mccoll

Peninsula Dental School

Stabilisation of primary disease is a key pillar of successful treatment and in addition to managing caries, managing periodontal disease is a crucial component of a successful treatment plan. The recent European Federation of Periodontology (EFP) S3 level clinical practice guidelines (CPG)1 are evidence‐based clinical guidelines providing recommendations to treat periodontitis. Crucial to successful implementation of these recommendations is delivering behavioural change and non-surgical instrumentation. Often this is given passing attention with insufficient time allocated to behaviour change in treatment planning. Similarly, poorly maintained periodontal instruments and equipment not used to their full utility or design can lead to poorer …

Modeling Of Frontal Polymerization Of Carbon Fiber And Dicyclopentadiene Woven Composites With Stochastic Material Uncertainty, Ahmadreza Mohammad Sharifi, Dong-Jun Kwon, S. Z. H. Shah, Juhyeong Lee

Mechanical and Aerospace Engineering Faculty Publications

A novel finite element modeling framework is proposed for simulating dicyclopentadiene (DCPD) frontal polymerization in carbon fiber (CF) woven composites. A mesoscale CF/DCPD representative volume element (RVE) model was developed with two triggering directions, resulting in out-of-plane and in-plane DCPD polymerization. The Arrhenius equation coupled with a modified Prout-Tompkins autocatalytic model was used to evaluate the dynamic DCPD polymerization process. The rate and degree of DCPD cure were calculated by the material property uncertainties of DCPD with and without random void inclusions (3% used as a reference in this work). The DCPD frontal polymerization in CF/DCPD composite was strongly influenced …

Metformin Alleviates Hepatic Iron Overload And Ferroptosis Through Ampk-Ferroportin Pathway In Hfd-Induced Nafld, Fangzhi Yue, Ying Shi, Shanyu Wu, Lin Xing, Dan He, Lin Wei, Anqi Qiu, Ryan D. Russell, Dongmei Zhang

Health & Human Performance Faculty Publications

Highlights

• Metformin alleviates HIO and ferroptosis in HFD-induced NAFLD

• FPN is involved in the molecular mechanism of metformin on HIO in HFD-induced NAFLD

• Metformin upregulates FPN expression by reducing lysosomal ubiquitination degradation

Summary

Metformin prevents progression of non-alcoholic fatty liver disease (NAFLD). However, the potential mechanism is not entirely understood. Ferroptosis, a recently recognized nonapoptotic form of regulated cell death, has been reported to be involved in the pathogenesis of NAFLD. Here, we investigated the effects of metformin on ferroptosis and its potential mechanism in NAFLD. We found that metformin prevented the progression of NAFLD, and alleviated hepatic iron …

Supplementary Information On Early-Stage Floating Offshore Wind Platform Designs, Emma Edwards, Anna Holcombe, Scott Brown, Edward Ransley, Martyn Hann, Deborah Greaves

Faculty of Science and Engineering Datasets

This document serves as supplementary information to the authors' review paper on early-stage floating offshore wind turbine (FOWT) platform designs. The review paper is the second part in a study on FOWT platform designs, following a review of FOWT platforms which currently have or have previously had a prototype, demonstration, or farm scale project at-sea. The present review covers 86 past and current early-stage platform designs, ranging from early conceptual designs to platforms which have undergone lab tests simulating extreme conditions. In this supplementary information document, more details are provided about all 86 platforms reviewed. For each device, the following …

The Normative Requirement For Shared Decision Making (Sdm) In Healthcare Ethics, Margaret Nornor-Quadjie

Electronic Theses and Dissertations

Medicine and medical technology started to advance after World War II. During that period, the practice of medicine became technical. A lot began to happen in the biomedical world during the period after WWII that attracted comments, criticisms, and analyses from scholars. Perhaps, the 1947 Doctors’ Trial at the Nuremberg Tribunal and the Nuremberg Code may be said to be the defining moment for bioethics. These events eventually led to, in the United States, the passage of the National Research Act of 1974 that established the Institutional Review Board system and the National Commission for Protection of Human Subjects of …

Comparative Functional And Genomic Analysis Of Protein Targets Of Sexual Selection In Primates, Brianna Ports

Electronic Theses and Dissertations

Sexual selection is driven by the differential reproductive success of individuals, which is influenced by competition for mates and mate choice. In primates, this selective pressure has been attributed to the development of distinct anatomical, physiological, and behavioral characteristics. By employing comparative functional and genomic methodologies, this study aimed to assess the repercussions of primate sexual selection. To better understand the mechanisms driving sexually selected traits, an unbiased genome-wide analysis was used to associate rates of protein evolution with relative testes size and sexual size dimorphism. While previous research focused on the rapid evolution of male reproductive proteins in response …

Factors Affecting Adoption Of Tiktok Among Students In The Dhaka City Area., Mahafizur R. Jim, Muhammad I. Alam

Business Review

This study investigates the factors affecting adoption of TikTok among the students in Dhaka city area. A structured survey questionnaire was developed through the survey tool, Google form and data were obtained from 529 respondents living in various locations of Dhaka city by an online survey method through using the social media platform, Facebook. Moreover, the multiple regression analysis was performed to test the research hypotheses. Results show that students perceive this app in a different way and do not consider this app as a great source of enjoyment. Moreover, they do not perceive this app as a decent media …

Implementing A Standard Work Process For Food Insecurity Screening, Referral, And Connection Tracking In A Safety-Net Clinic, Aisha Keplinger

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Social determinants of health (SDOH) screening and referral programs are crucial to achieving health equity, fundamental to providing the best care, and are critical to the United States’ pursuit of the Institute for Healthcare Improvement’s (IHI) Triple Aim (Berwick et al., 2008). Employing the PRECEDE-PROCEED model, a systematic screening and referral program was implemented at a safety-net clinic to increase SDOH screening and referral rates, and to identify the number of patients who connect with community resources. The program was guided by the IHI Triple Aim framework and evaluated using the Institute of Medicine (IOM) Six Aims of Healthcare Quality …

Early Cellular And Molecular Signatures Correlate With Severity Of West Nile Virus Infection, Sameet Mehta, Xiaomei Wang, Brent Vander Wyk, Shannon E Ronca, Heather Kang, Chih-Hung Chou, Benoit Fatou, Kinga K Smolen, Ofer Levy, Clary B Clish, Ramnik J Xavier, Hanno Steen, David A Hafler, J Christopher Love, Alex K Shalek, Leying Guan, Kristy O Murray, Steven H Kleinstein, Ruth R Montgomery

Faculty, Staff and Students Publications

Infection with West Nile virus (WNV) drives a wide range of responses, from asymptomatic to flu-like symptoms/fever or severe cases of encephalitis and death. To identify cellular and molecular signatures distinguishing WNV severity, we employed systems profiling of peripheral blood from asymptomatic and severely ill individuals infected with WNV. We interrogated immune responses longitudinally from acute infection through convalescence employing single-cell protein and transcriptional profiling complemented with matched serum proteomics and metabolomics as well as multi-omics analysis. At the acute time point, we detected both elevation of pro-inflammatory markers in innate immune cell types and reduction of regulatory T cell …

Targeting Eif4a Triggers An Interferon Response To Synergize With Chemotherapy And Suppress Triple-Negative Breast Cancer, Anna Malovannaya, Xueying Yuan, Lucas C Reineke, Nadia Lieu, Yang Gao, Diego A Pedroza, Sebastian J Calderon, Alex J Smith, Clark Hamor, Kazem Safari, Sara Savage, Bing Zhang, Jianling Zhou, Luisa M Solis, Susan G Hilsenbeck, Cheng Fan, Charles M Perou, Jeffrey M Rosen

Faculty, Staff and Students Publications

Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA translation represents an attractive cancer therapy. Here, we show that therapeutically targeting the RNA helicase eIF4A with zotatifin, the first-in-class eIF4A inhibitor, exerts pleiotropic effects on both tumor cells and the tumor immune microenvironment in a diverse cohort of syngeneic triple-negative breast cancer (TNBC) mouse models. Zotatifin not only suppresses tumor cell proliferation but also directly repolarizes macrophages toward an M1-like phenotype and inhibits neutrophil infiltration, which sensitizes tumors to immune checkpoint blockade. Mechanistic studies revealed that zotatifin reprograms the tumor translational landscape, inhibits the translation of Sox4 …

Gatekeeping At Bio

Faculty, Staff and Students Publications

No abstract provided.