Digital Commons Network^™

The Involvement Of Hepatic Cytochrome P450s In The Cytotoxicity Of Lapatinib, Xiaobo He, Matthew Bryant, Xuan Qin, Feng Li, Ji-Eun Seo, Xiaoqing Guo, Nan Mei, Lei Guo

Faculty, Staff and Students Publications

Lapatinib, an oral tyrosine kinase inhibitor used as a first-line treatment for HER2-positive breast cancer, has been reported to be associated with hepatotoxicity; however, the underlying mechanisms remain unclear. In this study, we report that lapatinib causes cytotoxicity in multiple types of hepatic cells, including primary human hepatocytes, HepaRG cells, and HepG2 cells. A 24-h treatment with lapatinib induced cell cycle disturbances, apoptosis, and DNA damage, and decreased the protein levels of topoisomerase in HepG2 cells. We investigated the role of cytochrome P450 (CYP)-mediated metabolism in lapatinib-induced cytotoxicity using our previously established HepG2 cell lines, which express each of 14 …

Breaking The Non-Compete Cycle: A Legal And Economic Analysis Of The Ftc's Power Move, Stephen Fox

University of Cincinnati Law Review

No abstract provided.

Start-Stop System And Operating Strategy For Increased Efficiency While Maintaining Comfort Thanks To Effective Prevention Of False Starts, Konrad Hirschbeck

Defensive Publications Series

No abstract provided.

Direct Coupling From An Asynchronous Machine To The Generator In A Hybrid Drivetrain, Konrad Hirschbeck

Defensive Publications Series

No abstract provided.

Miracle On The High Seas, A True Story: A Case Of Faith, Heroism, Love, And Compassion, Emilio Iodice

The Journal of Values-Based Leadership

No abstract provided.

Top Directed, Bottom Driven: Subaru Tackles Waste (Interview With Denise Coogan, Subaru), Elizabeth Gingerich

The Journal of Values-Based Leadership

No abstract provided.

Ethical Leadership: A Study Of Behaviors Of Leaders In Higher Education Today, Jonathan Hubchen, Samuel L. Wyatt, Michael Burnett

The Journal of Values-Based Leadership

The primary purpose of this study was to determine the behaviors of an ethical leader as perceived by tenured and tenure-track faculty at a research university (RU/VH) in the southeastern portion of the United States. The researcher utilized a researcher-designed survey instrument which consisted of twenty possible behaviors of an ethical leader and selected demographic characteristics.

Examination of the study results revealed that the majority of respondents were male (66.20%) and tenured (75.00%). Additionally, the largest group were Professors (49.60%), and had been at the study institution for less than l0 years (38.20%). The characteristics that were most related to …

Three Conditions For Vertical Leadership Development: Impact Of Personal Experiences, Kevin Coopersmith

The Journal of Values-Based Leadership

Vertical leadership development, an emerging body of leadership research based around expanding an individual’s capacity to think, make decisions, and understand themselves and the world around them, stands as a unique solution to address the leadership skills gap at a time of global complexity and change. Petrie’s (2015) model of the three conditions for vertical leadership development to take place was analyzed through the lived experiences of eight leaders who had successfully completed personal development plans and shared their experiences through a narrative-based qualitative study. Of the eight participants, three participants filled all three conditions and demonstrated a higher level …

A Journey To Managing Stress: My Story, James J. Lynch

The Journal of Values-Based Leadership

No abstract provided.

People, Processes, Systems, And Leadership — Keys To Organizational Performance, Cam Caldwell, Khalfan R. Al Asmi, Zulaikah Albusaidi, Rayan Esmaail

The Journal of Values-Based Leadership

Current evidence about successful organizations emphasizes the importance of integrated organizational factors that combine to convey a consistent message to employees that is the essence of an effective organizational culture (Beer, 2009; Shein & Schein, 2016). Although there is much that is positive about the achievements that some organizations are making to create a sustainable organizational culture, there is also overwhelming evidence that organizations and their leaders are struggling to earn the commitment and followership of their employees (Clifton & Harter, 2019; Edelman, 2023).

Robust Gasification Trial Results For A Variety Of Difficult-To-Recycle Packaging-Related Materials, Bruce A. Welt

Journal of Applied Packaging Research

Currently, recycling requires nearly absolute sorting of materials to accommodate the limited capabilities of existing recycling infrastructure. Whether a material is “recyclable” depends more on the method of recycling than the material itself. Our dependence upon sorting has limited success of recycling and has stifled our ability to achieve circular economy sustainability with plastic packaging materials. Our dependence upon sorting is rooted in our material-specific recycling processes. However, newer robust recycling processes are commercially available that reduce or eliminate the need to sort waste, and can convert mixed waste into primary feedstock chemicals, such as methanol for subsequent manufacture of …

Critically Analyzing The Meanings Of “Critical” Media Literacy, W. James Potter

Journal of Media Literacy Education

This study provides a critical analysis into how authors of publications about critical media literacy express what they mean by the term. The use of multiple strategies to examine the degree to which these authors exhibit a sharing of meaning led to the conclusion that there are far more differences than commonalities across definitions of critical media literacy. The implications of this conclusion raise important questions about the value of a literature where authors seem to express so many different meanings for the concept that they use to label their common concern.

Media Literacy Education For Parents: A Systematic Literature Review, Alicia Haywood, Sabrina Sembiante

Journal of Media Literacy Education

This systematic literature review examines emergent approaches toward media literacy education for parents. Method guidelines for review originated from the 2020 update of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The review sample consists of twelve studies, six originating in the United States, and six from other parts of the world. Findings include: (a) assessments of parent needs, interest in media literacy education, and receptiveness to learning, (b) integration of media literacy education with parental mediation instruction toward positive, healthy child development and socialization - shifts attention from reactive management of media effects to issue prevention …

Industrial Education 4.0: The Role Of Human, Technology, And Data Literacy, Suparno Suparno, Dedi Purwana, Agus Wibowo, Bagus Shandy Narmaditya

Journal of Media Literacy Education

This study aims to confirm the effect of industrial education 4.0 on data, technology, and human literacy among postgraduate students in Indonesia. The research adopted covariance-based structural equation modeling by employing AMOS 25 to examine the relationship between variables. The model estimation was performed using confirmatory factor analysis as a standard model for measuring industrial education 4.0 and involved structural model analysis to confirm the hypotheses. The population in this research paper was 2.958 postgraduate students in 32 study programs, while the sample was 312 respondents, which was determined using the proportional random sampling technique. This study tested the three …

Everyday Engagement With Mobile Phones In An Urban Slum In Delhi, Simranjeet Kaur, Sunita Singh

Journal of Media Literacy Education

This ethnographic case study presents findings of an 18-month research study focusing on the ways in which families residing in an urban slum were using mobile phones and how this use supported literacy practices. Data collection included participant observations and interviews with 42 participants including parents, children and community members. Results of the data analysis indicated that in this urban slum, most participants owned a mobile phone which provided multiple entry points to learning. The phones ushered in new ways of brokering knowledge where children acted as ‘experts’ and enabled parents to perform everyday tasks while parents mediated as cultural …

Back Matter

Purdue Journal of Service-Learning and International Engagement

No abstract provided.

Biowall Development For The West Lafayette Public Library, Dhanurja De Silva, Yalin Lu, Siqi He, Ajay Dalal, Bill Hutzel

Purdue Journal of Service-Learning and International Engagement

A group of multidisciplinary Purdue students are working together to design, assemble, and install a Biowall in the Children’s section of the West Lafayette Public Library. A Biowall is a plant-based filter that improves Indoor Environmental Quality by cleaning indoor air and adding a natural aesthetic to the building space. Purdue has been developing Biowall technology since 2012, and this project involves redesigning it to fit into the available space at the library. The new Biowall design incorporates a watering mechanism that allows for children to get actively involved in maintaining the Biowall and learning about sustainability. This project also …

Library Steam Kits: Developing Circulatable Curriculum For Community Steam Learning, Daphne Fauber, Ashley Fletcher

Purdue Journal of Service-Learning and International Engagement

Public libraries serve as repositories for a movement described as cultivation of the Library of Things. In the wake of COVID-19, the West Lafayette Public Library enhanced its existing Library of Things collection through the creation of science, technology, engineering, art, and mathematics (STEAM) kits. Since 2017, the West Lafayette Public Library has held regular free STEAM programs for the community; those programs were put on hold during the height of the COVID-19 pandemic, which concurred with a library renovation. These kits provide the community with the ability to learn STEAM concepts at home engaging, hands-on activities that may otherwise …

Indianapolis Gems Club: Engagement In Informal Mathematics And Science Learning, Maria Eloisa Nuguid

Purdue Journal of Service-Learning and International Engagement

There continues to be a need for the representation of women in science, technology, engineering, and mathematics (STEM) fields. To address this need, the Girls Excelling in Mathematics and Science (GEMS) research team at Purdue started a GEMS club at Lew Wallace School in Indianapolis, referred to as Indy GEMS Club. GEMS research assistants Maria Eloisa Nuguid, Yi Zhu, and Grace Gochnauer worked with Professor Elizabeth Suazo-Flores. This article is a description of the first Indy GEMS Club experience that consisted of hands-on activities created by GEMS founder Laura Reasoner Jones. The activities were hidden Legos, cup stacking, building a …

The Complexities Of Green Infrastructure, Troy Weber

Purdue Journal of Service-Learning and International Engagement

The Wabash River is the most extensive river system in Indiana. The river drains two-thirds of Indiana’s 92 counties, which can have issues associated with stormwater runoff (Weist, 1981). As precipitation runs off impervious surfaces, it can carry high concentrations of pollutants, such as excess nitrogen and phosphorus, pet waste, and automobile fuel. Prior to impervious runoff entering the river, preexisting contaminants include industrial waste (acid mine drainage and oil field brines), municipal waste, and sediment (Weist, 1981). Thus, stormwater runoff can negatively impact the Wabash River watershed. On top of this pollution, Lafayette and West Lafayette have combined sewer …

Stimulating The Interest Of Young Learners In Physics Through Storytelling And Stem Activities, Emmanuel Babalola, Wonjin Yu, Hillary Ongoyo Omoze, Zainab Saka, Favour Ojike, Iyanu Adedeji, Zhu Yue

Purdue Journal of Service-Learning and International Engagement

The Physics is Fun Project is an initiative funded by Purdue’s Office of Engagement and aims to promote an interest in physics among young learners aged 5 to 12. The project’s unique approach blends instructional design and motivational design to create an engaging and relevant learning experience. Development of the project was guided by the analyze, design, develop, implement, and evaluate (ADDIE) framework and Keller’s attention, relevance, confidence, and satisfaction (ARCS) theory and utilized storytelling and hands-on learning strategies to bring physics to life through the story of a young physics enthusiast who is passionate about building a dream car. …

Service-Learning In Action: Lafayette, Indiana, Rain Garden Installation, Elizabeth Mccleery

Purdue Journal of Service-Learning and International Engagement

Indiana’s Wabash River is being polluted with contaminated water runoff from precipitation events. A lack of pervious land cover has led to an accumulation of fertilizer, sediment, and waste in the river. Green infrastructure, a stormwater management practice that mimics the natural ecosystem, is one of the most effective ways to prevent pollution from stormwater runoff and benefit the community. This project consisted of a rain garden installation at the Lafayette Fueling Station, a site where frequent water drainage and water runoff into the Wabash occurs. The rain garden will allow on-site water infiltration during rain events and promote natural …

Getting Off On The Right Foot: Addressing Severe Lymphedema Through A Novel Shoe Design, Carl R. Russell Iii, Anjollie M. Ramakrishna, Christopher H. Johns Iii, Alana V. Van Wijnen

Purdue Journal of Service-Learning and International Engagement

Engineering Projects in Community Service (EPICS) is a service-learning design program run by the College of Engineering at Purdue University. EPICS teaches students design skills by providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. Biomedical Engineering is a team within EPICS that strives to serve community partners through biomedical applications. HR is a patient who suffers from severe lymphedema. This condition results in her foot swelling three times its original size and requires her to utilize weekly leg compression therapy. Prescription shoes are slightly adequate. However, they lead to sores and pain …

Editorial, Elizabeth B. Brite

Purdue Journal of Service-Learning and International Engagement

No abstract provided.

Virtual Machine Images Preconfigured With Security Scripts For Data Protection And Alerting, Brandon Maltzman, Scott Tyler Ellis, Hauke Vagts, Jim Miller, Devon Beanish, Assaf Namer

Defensive Publications Series

Developers use interactive development environments (IDEs) to create and share documents that contain live code, equations, visualizations, narrative text, etc. as part of the artificial intelligence/ machine learning (AI/ML) development process. Virtual machines that run IDEs may have access to private and/or sensitive data used during model training or use. For data security and compliance, it is necessary to highlight and track the VMs that have been in contact with sensitive information. This disclosure describes techniques to automatically identify and label the presence of sensitive data in virtual machines and disks as part of machine learning. Custom VM images are …

The Impact Of Using Instagram On The Purchase Decision Of Pink Marketing Customers: (An Applied Study Of The Beauty Centers In Amman), Elaph Nayef Alhamad, Abdel-Aziz Ahmad Sharabati Prof. Dr.

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

The article aims to investigate the effect of using Instagram on the purchase decisions of Pink Marketing Customers. This study uses a quantitative descriptive cause-effect and cross-sectional approach. To implement this study, data were collected from 41 beauty centers in Amman using a questionnaire. After confirming the suitability of the data, it was coded against SPSS. Then normal distribution, validity, and reliability of the tool were assured, followed by descriptive analysis and correlation between the variables. Finally, the effect was tested by multiple regressions. The study showed many results, most notably the presence of an effect of using Instagram with …

Asset Pricing And Modern Portfolio Theory: An Application To Portfolio Optimization Of Different Moroccan And Multinational Assets Using Excel And Python Programming Analysis, Mohamed Amine Chafik, Faouzi Boussedra

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

One of the problems considered in financial mathematics is finding portfolios of given financial assets that minimize risk for targeted returns. The set of such portfolios is called the envelope of the assets. Traditionally, this problem is solved as a calculus minimization problem involving partial derivatives and Lagrange multipliers. The mean-variance framework is the preferred method for picking investments for many retail and institutional investors. Meanwhile, big data and the real-time economy have created new asset allocation challenges and opportunities. These changes have been thoroughly recorded, and portfolio management firms constantly incorporate the data into complex models. In this study, …

واقع االستثمار في الميزة التكنولوجية أحد محركات الحوكمة الرقمية في صناعة النفط العراقية - دراسة حالة في شركة نفط البصرة-, Ahmad Ali Salih, Muhammad Abbas Fanar Al-Hamdani

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

هدف المقال للتعرف على واقع االستثمار في الميزة التكنولوجية، واعتمدت الدراسة على استراتيجية دراسة الحالة ألن مجال الدراسة هو شركة نفط البصرة )شركة واحدة(، تكّون مجتمع الدراسة من )3084( فرداَ من جميع العاملين في مختلف المستويات اإلدارية

ونظرا لكبر حجم ً مجتمع الدراسة وصعوبة تطبيق الدراسة عليه تم اللجوء إلى أسلوب سحب العينة بالطريقة العشوائية البسيطة من دون فردا كما تم ً إرجاع، وكان حجم العينة المالئم )359( . اعتماد االستبانة أداة لقياس متغيرات الدراسة من خالل جمع البيانات ومن ثم تحليلها باستخدام أساليب اإلحصاء الوصفي والتي تتمثل في الوسط الحسابي واإلنحراف المعياري وقيمة اختبار )t )وتوصلت الدراسة إلى العديد …

فاعلية نظم المعلومات المحاسبية في ضوء متطلبات الحوكمة الرقمية: دراسة تحليلية, Alaa A.D. Taha, Shaima M. S. Ibrahim

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

هدف البحث الكشف عن تأثير متطلبات الحوكمة الرقمية في تعزيز فاعلية نظم المعلومات المحاسبية في المصارف التجارية الخاصة العراقية. اذ يقدم البحث الحالي نموذج مفاهيمي مقترح يجادل بأن الامتثال للقوانين والتعليمات، والخصوصية، والأمان، والشفافية هي مكونات أساسية للحوكمة الرقمية، والتي تؤثر بشكل إيجابي ومعنوي على فاعلية أنظمة المعلومات المحاسبية. تم تصميم نموذج القياس والهيكلي باستخدام أسلوب نمذجة المعادلات الهيكلية المستند الى طريقة المربعات الجزئية او الصغرى، كما تم توظيف برمجية (SmartPLSv.3.9.6) كأداة احصائية. تم اختبار فرضية رئيسة واحدة وأربعة أخرى فرعية، وذلك باستخدام دراسة استقصائية شملت (121) محاسباً ومدققاً في (45) مصرفاً خاصاً في العراق. ووجد المؤلفون أدلة تجريبية تدعم …

فاعلية تطبيق مبني على الذكاء االصطناعي في تنمية مهارات التفكير المنطقي والدافعية نحو تعلم مادة الحاسوب في األردن, Enas M. Sawalmeh, Khaleel M. Al-Said

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

هدف المقال الكشف عن فاعلية تطبيق مبني على الذكاء االصطناعي في تنمية مهارات التفكير المنطقي والدافعية نحو تعلم مادة الحاسوب لدى طلبة الصف الثامن األساسي في األردن واعتمد المنهج شبه التجريبي ولتحقيق أهداف الدراسة تم اعداد اختبار مهارات التفكير المنطقي كما تم تطوير مقياس الدافعية نحو تعلم، وتم التأكد من صدقهما وثباتهما وطبقتا على أفراد الدراسة من )45( طالباً وطالبة من مدرسة الريادة الدولية- التعليم الخاص في العاصمة عمان، مجموعة ضابطة وعدد أفرادها )23( طالباً وطالبة درست بالطريقة االعتيادية برمجية سكراتش ومجموعة تجريبية عدد أفرادها )22(

طالبا وطالبة درست عن طريقة ُ تطبيق مبني على الذكاء االصطناعي خالل الفصل الثاني …