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Articles 10981 - 11010 of 1103055
Full-Text Articles in Entire DC Network
Neutrosophication As A General Framework For Regret Theory, Grey System Theory, And Three-Way Decision Models, Florentin Smarandache
Neutrosophication As A General Framework For Regret Theory, Grey System Theory, And Three-Way Decision Models, Florentin Smarandache
Neutrosophic Sets and Systems
No abstract provided.
Neutrosophic Logic As A Framework For Managing Uncertainty In Artificial Intelligence, Conf. Univ. Dr. N. Grigorie Lăcrița, Craiova Craiova, Romania Romania
Neutrosophic Logic As A Framework For Managing Uncertainty In Artificial Intelligence, Conf. Univ. Dr. N. Grigorie Lăcrița, Craiova Craiova, Romania Romania
Neutrosophic Sets and Systems
No abstract provided.
On Operations Of Indetermsoft Sets, Savita Rathee, Diksha Goyal, Meenakshi Hooda, Ridam Girdhar, Savita Ahlawat
On Operations Of Indetermsoft Sets, Savita Rathee, Diksha Goyal, Meenakshi Hooda, Ridam Girdhar, Savita Ahlawat
Neutrosophic Sets and Systems
No abstract provided.
Applied Neutrosophic Triplets In Ai Decision Systems: Introduction To An Ongoing Case Study Across Agentic, Swarm, Rag, And Pipeline Architectures, Jean-Sebastien Beaulieu
Applied Neutrosophic Triplets In Ai Decision Systems: Introduction To An Ongoing Case Study Across Agentic, Swarm, Rag, And Pipeline Architectures, Jean-Sebastien Beaulieu
Neutrosophic Sets and Systems
No abstract provided.
Foundations Of Type-1 Neutrosophic Topological Modules, Hussain Wahish, Adel Al-Odhari, Abdulwahed Mhdi, Basheer Al-Refaei, Khaled Alhamadi
Foundations Of Type-1 Neutrosophic Topological Modules, Hussain Wahish, Adel Al-Odhari, Abdulwahed Mhdi, Basheer Al-Refaei, Khaled Alhamadi
Neutrosophic Sets and Systems
No abstract provided.
Neutrosophic Sets And Systems, Vol. 99,2026, Florentin Smarandache, Mohamed Abdel-Basset, Maikel. Leyva Vazquez
Neutrosophic Sets And Systems, Vol. 99,2026, Florentin Smarandache, Mohamed Abdel-Basset, Maikel. Leyva Vazquez
Neutrosophic Sets and Systems
No abstract provided.
Cloud-Based Ai Framework For Ev Charging Forecasting And Infrastructure Optimization, Jerry Gao, Neeraja Abhinav Buch, Thuan Chau, Yumeng Sheng, Rong Wang, Siri Kadalbal
Cloud-Based Ai Framework For Ev Charging Forecasting And Infrastructure Optimization, Jerry Gao, Neeraja Abhinav Buch, Thuan Chau, Yumeng Sheng, Rong Wang, Siri Kadalbal
Faculty Research, Scholarly, and Creative Activity
The growing use of electric vehicles (EVs) has created a strong need for smart, data-driven charging management systems that can support large-scale and sustainable infrastructure. This study introduces a modular cloud-based framework that combines artificial intelligence and machine learning to provide predictive insights for energy demand and station expansion. The system mainly consists of two complementary models. The first is an AutoRegressive Integrated Moving Average (ARIMA) model that forecasts charging energy demand using transactional data from Palo Alto. The second is a Light Gradient Boosting Machine (LightGBM) model that predicts optimal charging-station locations using spatial data from the U.S. Department …
Perceived Concepts Which Influence Initial Methamphetamine Use Amongst Young Latina Women, Rebeca Rivera
Perceived Concepts Which Influence Initial Methamphetamine Use Amongst Young Latina Women, Rebeca Rivera
Walden Dissertations and Doctoral Studies
No abstract provided.
Examining Parental Self-Efficacy And Its Impact On Teacher Ratings Of Student Adjustment, Moderated By Ses, Russell Craig
Examining Parental Self-Efficacy And Its Impact On Teacher Ratings Of Student Adjustment, Moderated By Ses, Russell Craig
Walden Dissertations and Doctoral Studies
No abstract provided.
Fiscal And Monetary Policies For Inclusive Growth In Developing And Emerging Markets, Collins Anosike
Fiscal And Monetary Policies For Inclusive Growth In Developing And Emerging Markets, Collins Anosike
Journal of Global Awareness
The study examined the effects of monetary and fiscal policies in attaining inclusive growth for some developing countries and emerging markets. The study selected 20 countries and grouped them into group one and group two. The study is unique because it captures a broader range of countries compared to previous studies and shows their effect on economic growth. We use panel data and employ OLS regression and Johansen cointegration. We examine how each variable, general government expenditure, gross national expenditure, total revenue, official exchange rate, broad money, and deposit interest rate, affects the dependent variable (real GDP) from 1980 to …
Examining The Use Of Digital Journal Entries In A Special Education Course To Build Understanding Of Global Competence, Lema Kabashi, Leslie Rogers
Examining The Use Of Digital Journal Entries In A Special Education Course To Build Understanding Of Global Competence, Lema Kabashi, Leslie Rogers
Journal of Global Awareness
Teacher education programs increasingly emphasize the development of global competence (GC), particularly within experience-based learning contexts such as study abroad. This mixed-methods study examined teacher candidates’ (TCs) development of GC during a four-week study abroad experience by analyzing evidence from digital reflective journal entries and changes in self-reported perceptions across three time points. Data were collected from teacher candidates across two four-week summer sessions using digital journals and a Global Competence Self-Evaluation Survey. Qualitative content analysis was employed to identify the frequency with which three global competency areas were evidenced in the journal entries, while quantitative analyses examined changes in …
Letter From The Editor, Jay Nathan
Dreams Intervention Program: A Web-Based Classroom For Universal Human Values (Uhv), Roseline Florence Gomes, Lijo Thomas, Preethi Nanjundan
Dreams Intervention Program: A Web-Based Classroom For Universal Human Values (Uhv), Roseline Florence Gomes, Lijo Thomas, Preethi Nanjundan
Northeast Journal of Complex Systems (NEJCS)
The study investigated the implementation and processes of the DREAMS Intervention Program (DIP) web-based classroom model for understanding Universal Human Values (UHV) among college-going youth mentors. The DREAMS (Desire, Readiness, Empowerment, Action, Mastery for Success) Intervention Program (DIP) is a transformative five-stage model that fosters psychosocial development and leadership skills among children and adolescents. This evidence-based three-year After-School-Program (ASP) was guided through the theoretical lens of motivation, goal-setting, and self-determination that pairs middle school underperformers with college-going youth mentors and senior adults from local communities. Universal Human Values (UHV) are deep-rooted values that are needed in the contemporary educational system …
The Machine For Its Own Sake: Tolkien's Critique Of Instrumental Reason And The Modern Ecological Ethos, Ahmad J. El-Youssef
The Machine For Its Own Sake: Tolkien's Critique Of Instrumental Reason And The Modern Ecological Ethos, Ahmad J. El-Youssef
Journal of Tolkien Research
This essay examines J.R.R. Tolkien's legendarium as a systematic critique of instrumental reason, positioning his work as a vital philosophical resource for diagnosing and navigating the Anthropocene. Rather than a simplistic anti-technology stance, Tolkien's concept of the "Machine" represents a teleological logic that reduces the living world to a standing reserve, paralleling contemporary ecological crises. Through analysis of key narratives, particularly the industrialisation of Isengard, the corruption of the Shire, and the restoration of Lothlórien, this study demonstrates how Tolkien dramatises the ontological flattening inherent in instrumentalist domination. The essay contrasts this with Tolkien's alternative ethos of sub-creation and stewardship, …
Wibbly-Wobbly Timey-Wimey Inklings: Tolkien And Lewis’S Relative Dimensions In Space-Time, Kristine Larsen
Wibbly-Wobbly Timey-Wimey Inklings: Tolkien And Lewis’S Relative Dimensions In Space-Time, Kristine Larsen
Journal of Tolkien Research
As noted in Tolkien's letters, around 1936 he and C.S. Lewis agreed to each try their hand at writing "an excursionary 'Thriller'" – essentially science fiction – "each discovering myth." They supposedly “tossed up,” with Lewis drawing a "Space-journey" and Tolkien a "Time-journey" (Letters 39). The standard answer is that this bet resulted in a trio of published space-travel novels for Lewis (Out of the Silent Planet [1938], Perelandra [1943], and That Hideous Strength [1945]) and two incomplete and abandoned time-travel projects for Tolkien, The Lost Road (incomplete typescript dating to 1937 [LR 8]) and The Notion …
Did The Year 2025 Force African Journalism To Confront Its Future? A Review Of Scholarship And Practice, Gregory Gondwe
Did The Year 2025 Force African Journalism To Confront Its Future? A Review Of Scholarship And Practice, Gregory Gondwe
Communication Studies Faculty Publications
No abstract provided.
The Beauty Of Gray: Embracing The Role Of Community Courts And The Professionals Who Work At The Boundary Of Court And Community, Amanda N. Berman
The Beauty Of Gray: Embracing The Role Of Community Courts And The Professionals Who Work At The Boundary Of Court And Community, Amanda N. Berman
NULR Online
No abstract provided.
Pfas Mixture Composition And Internal Exposure Profiles Shape Biological Responses Under Field-Realistic Exposure, Alan M. Vajda, Jill A. Jenkins, David W. Bertolatus, Denis R. Leblanc, Christopher J. Martyniuk, Zachary R. Hopkins, Andrea K. Tokranov, Abigail R. Dethloff, Joseph C. Tucker, Rainer Lohmann, Larry B. Barber
Pfas Mixture Composition And Internal Exposure Profiles Shape Biological Responses Under Field-Realistic Exposure, Alan M. Vajda, Jill A. Jenkins, David W. Bertolatus, Denis R. Leblanc, Christopher J. Martyniuk, Zachary R. Hopkins, Andrea K. Tokranov, Abigail R. Dethloff, Joseph C. Tucker, Rainer Lohmann, Larry B. Barber
Graduate School of Oceanography Faculty Publications
Per- and polyfluoroalkyl substances (PFAS) occur as complex mixtures, yet mixture-dependent biological effects under environmentally realistic exposure conditions remain poorly understood. We conducted multiyear (2018, 2019, 2021) continuous-flow, field-based exposures of male fathead minnows (Pimephales promelas) using a low-PFAS reference well (REF; sum of measured PFAS (∑PFAS) 0.1–0.2 μg L–1) and PFAS-contaminated groundwater from a fire-training area (FTA) at Joint Base Cape Cod, Massachusetts. Dilution treatments enabled separation of concentration and mixture effects. Groundwater from well FTA1 was perfluorooctanesulfonate (PFOS) dominated (∑PFAS 10–31 μg L–1), whereas groundwater from well FTA2 had higher concentrations and …
Bridging Images And Language In Radiology: A Comprehensive Prisma Systematic Review Of Transformer Vision-Language Models And Clinical Readiness, Mohammad T. Khasawneh Dr., Sadaf Tabatabaee
Bridging Images And Language In Radiology: A Comprehensive Prisma Systematic Review Of Transformer Vision-Language Models And Clinical Readiness, Mohammad T. Khasawneh Dr., Sadaf Tabatabaee
Systems Science and Industrial Engineering Student Scholarship
Transformer vision-language models (VLMs) promise end-to-end automation of radiology reporting and related multimodal tasks. However, evidence remains fragmented across datasets, architectures, evaluation practices, and levels of clinical validation, limiting fair comparison and safe translation into practice. Following PRISMA 2020/PRISMA-S, search engines including PubMed, IEEE Xplore, Web of Science, and Google Scholar were systematically searched for peer-reviewed, English-language studies published between 2019 and 2025 that used paired radiology images and free-text reports. Dual reviewers screened records and extracted data using a locked schema covering datasets, modalities, architectures, training objectives, evaluation metrics, and indicators of clinical readiness. Free-text model descriptions were normalized …
Influence Of Polyvinyl Alcohol Content On Starch-Based Bioplastic Reinforced With Chitosan And Microcrystalline Cellulose, Bagus Kharisma Putra, Andoko Andoko, Mochamad Viky Afandy, Muhammad Faizullah Pasha, Riduwan Prasetya
Influence Of Polyvinyl Alcohol Content On Starch-Based Bioplastic Reinforced With Chitosan And Microcrystalline Cellulose, Bagus Kharisma Putra, Andoko Andoko, Mochamad Viky Afandy, Muhammad Faizullah Pasha, Riduwan Prasetya
Chimica et Natura Acta
Starch-based bioplastics are promising sustainable alternatives to petroleum-based plastics; however, their limited mechanical strength and stability restrict broader packaging applications. This study investigates the influence of polyvinyl alcohol (PVA) content on the structural and functional properties of starch-based bioplastic films reinforced with chitosan and microcrystalline cellulose (MCC). Films prepared by solution casting with varying PVA compositions were characterized in terms of density, mechanical properties, thermal stability, biodegradation behavior, antibacterial activity, and structural features. Increasing PVA content produced denser film structures with improved tensile strength and thermal stability, while elongation at break reached its maximum at the intermediate formulation, indicating a …
Brain Age Prediction In Generalized Anxiety Disorder Using A Convolutional Neural Network, Corey Richier, André Zugman, Anita Harrewijn, Elise M Cardinale, Parmis Khosravi, Moji Aghajani, Willem B Bruin, Kevin Hilbert, Narcis Cardoner, Daniel Porta-Casteràs, Marta Cano, Savannah Gosnell, Ramiro Salas, Andrea P Jackowski, Pedro M Pan, Giovanni A Salum, Karina S Blair, James R Blair, Mohammed R Milad, Katie L Burkhouse, K Luan Phan, Heidi K Schroeder, Jeffrey R Strawn, Katja Beesdo-Baum, Neda Jahanshad, Sophia I Thomopoulos, Jared A Nielsen, Jordan W Smoller, Jair C Soares, Benson Mwangi, Mon-Ju Wu, Giovana B Zunta-Soares, Michal Assaf, Gretchen J Diefenbach, Paolo Brambilla, Eleonora Maggioni, David Hofmann, Thomas Straube, Carmen Andreescu, Rebecca B Price, Gisele G Manfro, Federica Agosta, Elisa Canu, Camilla Cividini, Massimo Filippi, Milutin Kostić, Ana Munjiza Jovanovic, Brenda Benson, Gabrielle F Freitag, Ellen Leibenluft, Grace V Ringlein, Kathryn Werwath, Hannah Zwiebel, Hans J Grabe, Sandra Van Der Auwera, Katharina Wittfeld, Henry Völzke, Robin Bülow, Nicholas L Balderston, Monique Ernst, Lilianne R Mujica-Parodi, Helena Van Nieuwenhuizen, Hugo D Critchley, Elena Makovac, Matteo Mancini, Frances Meeten, Cristina Ottaviani, Gregory A Fonzo, Martin P Paulus, Murray B Stein, Raquel E Gur, Ruben C Gur, Antonia N Kaczkurkin, Bart Larsen, Theodore D Satterthwaite, Jennifer Harper, Michael T Perino, Chad M Sylvester, Qiongru Yu, Patrick Mcclure, Francisco Pereira, Ulrike Lueken, Dick J Veltman, Paul M Thompson, Nynke A Groenewold, Janna Marie Bas-Hoogendam, Dan J Stein, Nic J A Van Der Wee, Anderson M Winkler, Daniel S Pine, Chelsea K Sawyers
Brain Age Prediction In Generalized Anxiety Disorder Using A Convolutional Neural Network, Corey Richier, André Zugman, Anita Harrewijn, Elise M Cardinale, Parmis Khosravi, Moji Aghajani, Willem B Bruin, Kevin Hilbert, Narcis Cardoner, Daniel Porta-Casteràs, Marta Cano, Savannah Gosnell, Ramiro Salas, Andrea P Jackowski, Pedro M Pan, Giovanni A Salum, Karina S Blair, James R Blair, Mohammed R Milad, Katie L Burkhouse, K Luan Phan, Heidi K Schroeder, Jeffrey R Strawn, Katja Beesdo-Baum, Neda Jahanshad, Sophia I Thomopoulos, Jared A Nielsen, Jordan W Smoller, Jair C Soares, Benson Mwangi, Mon-Ju Wu, Giovana B Zunta-Soares, Michal Assaf, Gretchen J Diefenbach, Paolo Brambilla, Eleonora Maggioni, David Hofmann, Thomas Straube, Carmen Andreescu, Rebecca B Price, Gisele G Manfro, Federica Agosta, Elisa Canu, Camilla Cividini, Massimo Filippi, Milutin Kostić, Ana Munjiza Jovanovic, Brenda Benson, Gabrielle F Freitag, Ellen Leibenluft, Grace V Ringlein, Kathryn Werwath, Hannah Zwiebel, Hans J Grabe, Sandra Van Der Auwera, Katharina Wittfeld, Henry Völzke, Robin Bülow, Nicholas L Balderston, Monique Ernst, Lilianne R Mujica-Parodi, Helena Van Nieuwenhuizen, Hugo D Critchley, Elena Makovac, Matteo Mancini, Frances Meeten, Cristina Ottaviani, Gregory A Fonzo, Martin P Paulus, Murray B Stein, Raquel E Gur, Ruben C Gur, Antonia N Kaczkurkin, Bart Larsen, Theodore D Satterthwaite, Jennifer Harper, Michael T Perino, Chad M Sylvester, Qiongru Yu, Patrick Mcclure, Francisco Pereira, Ulrike Lueken, Dick J Veltman, Paul M Thompson, Nynke A Groenewold, Janna Marie Bas-Hoogendam, Dan J Stein, Nic J A Van Der Wee, Anderson M Winkler, Daniel S Pine, Chelsea K Sawyers
Faculty, Staff and Student Publications
Higher predicted brain age difference has been associated with several psychiatric disorders. Generalized anxiety disorder (GAD) is associated with markers of accelerated aging. In this study, we determined brain predicted age difference (PAD) in individuals with GAD and healthy controls (HC) as well as group differences in PAD variability using voxel-wise structural MRI. The training dataset included 3511 controls, and the testing dataset included 1595 individuals with GAD and 4552 HC from the ENIGMA-Anxiety GAD Working Group. A convolutional neural network model using four input modalities per subject and a model ensemble approach was used to predict brain age. The …
Stoker-Fired Laboratory Boiler As A Tool For Optimising The Solid Fuel Combustion Process, Przemysław Rompalski, Justyna Guzy-Proc, Mariusz Kieczek
Stoker-Fired Laboratory Boiler As A Tool For Optimising The Solid Fuel Combustion Process, Przemysław Rompalski, Justyna Guzy-Proc, Mariusz Kieczek
Journal of Sustainable Mining
This paper presents the results of quality testing performed on a stoker-fired laboratory boiler to present the technical potential of the boiler as a tool for optimising the combustion process of prepared solid fuels (granulate, energy blend) in the context of current demands related to the decarbonisation policy. The comprehensive testing of such fuels at a laboratory scale makes it possible to gain deep insights into the quality parameters of the fuel, flue gas and combustion waste, as well as to determine the combustion process parameters before the fuel is introduced for combustion in broader power engineering and household boilers. …
Comparative Analysis Of Transportation Emissions And Policy In Lahore And Los Angeles, Laiba Rehman
Comparative Analysis Of Transportation Emissions And Policy In Lahore And Los Angeles, Laiba Rehman
Master's Projects and Capstones
In 2023, exposure to air pollution killed 7.9 million people globally, becoming the second leading cause of death worldwide. Transportation emissions are among the primary drivers of this burden especially in rapidly urbanizing cities where vehicle fleets are growing faster than regulatory frameworks respond. This study examines the contribution of transportation emissions to urban air quality, public health and climate change in Lahore, Pakistan and Los Angeles, California. First, it employs a secondary data analysis of PM2.5 and ozone concentrations and vehicle fleet composition in each city, followed by an analysis of emission inventories. Second, it evaluates the regulatory …
Let Freedom Read: Exploring Mississippi’S Defiance Of National Book Banning Trends, Olivia S. Hoover
Let Freedom Read: Exploring Mississippi’S Defiance Of National Book Banning Trends, Olivia S. Hoover
Undergraduate Honors Theses
Why have book bans have surged so dramatically across the United States in recent years, especially as they have become a defining political project for conservative lawmakers? At the center of this uptick in book bans lies a confusing puzzle: while book bans overwhelmingly occur in Republican-dominated states, Mississippi, despite its conservative political landscape, has seen almost none, even as states like Florida have enacted more than a thousand in a single year. Much of the existing scholarship on book bans focuses on national patterns of them or on the lawmakers and advocacy groups driving these bans, leaving a gap …
Deforestation Dynamics In The Amazon: Impacts, Socio-Environmental Drivers And Restoration Pathways, Maria Natalia Rodriguez
Deforestation Dynamics In The Amazon: Impacts, Socio-Environmental Drivers And Restoration Pathways, Maria Natalia Rodriguez
Master's Projects and Capstones
The Amazon, which is the largest tropical rainforest in the world, experienced 542,581 km² of forest loss between the years 2000 and 2020. The process of deforestation endangers the ecological system results which maintain ecosystem connectivity and the Earth's climate system. The Amazon rainforest supplies essential ecological services which include maintaining soil fertility, storing carbon, purifying water and climate stability. The fundamental ecosystem of this area faces new threats because of increasing forest destruction. The research study adopts a combined methodology that uses Geographic Information Systems (GIS) with a comprehensive literature review to study Amazon deforestation patterns and its driving …
Commencement Of The Class Of 2026, Illinois Math And Science Academy
Commencement Of The Class Of 2026, Illinois Math And Science Academy
Ceremony
PROGRAM
POMP & CIRCUMSTANCE From Military Marches Op.39, No.1 Edward Elgar
PLEDGE OF ALLEGIANCE Angel Castillo Campa, Class of 2026
REFLECTIONS ON GRADUATION DAY Molly Federici, Class of 2026
INTRODUCTION OF COMMENCEMENT SPEAKER Eric Brown Chair, Board of Trustees
COMMENCEMENT ADDRESS Kendell Byrd ‘13, Buzzfeed Engineer on Tech and Entertainment
PRESENTATION OF THE CLASS OF 2026 Angela Rowley, Ed.D., Principal and Chief Academic Officer
ACCEPTANCE OF THE CLASS OF 2026 Evan M. Glazer, Ph.D., President
PRESENTATION OF DIPLOMAS AND MEDALLIONS
Eric Brown Chair, Board of Trustees,Evan M. Glazer, Ph.D., President
Manuel Donelson, Dean of Student Support and Equity
Paul Gaszak, …
Justice On Autopilot: Comparing Predictive Litigation And Data Justice In Bay Area Municipal Governments, Darris M. Thomas
Justice On Autopilot: Comparing Predictive Litigation And Data Justice In Bay Area Municipal Governments, Darris M. Thomas
Master's Projects and Capstones
This Capstone project examines how Bay Area municipal governments, specifically the City and County of San Francisco, Alameda County, San Mateo County, and Santa Clara County, are adopting and governing predictive litigation technologies, and what these practices reveal about the possibilities and limitations of data justice in advancing racial equity, transparency, and public accountability. Drawing on a qualitative, comparative case study methodology analyzing procurement contracts, AI governance policies, California Public Records Act (CPRA) disclosures, and semi-structured interviews gathered across fifteen municipal legal institutions, the research applies an interdisciplinary theoretical framework synthesizing John Rawls’s distributive fairness, Nancy Fraser’s recognition justice, Tom …
What Complexity Costs: Growth, Productive Capability, And The Vulnerability Of Interconnectedness, Pete Mcniff
What Complexity Costs: Growth, Productive Capability, And The Vulnerability Of Interconnectedness, Pete Mcniff
Master's Theses
Growth depends on the sophistication of what an economy can produce, but economies that have specialized more deeply depend on the market access that sustains it. I test whether this dependence makes complex economies more vulnerable when access is disrupted, computing the Economic Complexity Index (ECI) from firm-level records in the U.S. Census of Manufactures (1850--1880) and using the Panic of 1873 as a natural experiment to measure county-level market access shocks from railroad bond defaults following Dutta (2024) and Donaldson and Hornbeck (2016). ECI predicts production and employment growth across all three decade windows, with the association strengthening as …
The Impact Of Sovereign Wealth Funds On Emerging Markets: A Behavioral Analysis Of Investment Decisions And Market Reactions, Grant A. Mosshart
The Impact Of Sovereign Wealth Funds On Emerging Markets: A Behavioral Analysis Of Investment Decisions And Market Reactions, Grant A. Mosshart
Senior Honors Theses
Sovereign Wealth Funds (SWFs) are increasingly influential in emerging markets, yet the behavioral drivers behind their investments remain underexplored. In this paper, an analysis of SWF capital’s impact on economic development and the psychological factors, such as optimism bias and herding, that shape these decisions is examined. Utilizing a mixed-methods comparative study, the research analyzes Saudi Arabia’s Public Investment Fund (PIF) and Singapore’s Temasek Holdings. Event study analysis reveals a divergent impact: the PIF’s high-profile developmental commitment to India generated a positive 5-day Cumulative Abnormal Return of +2.05%, confirming a macro-level “seal of approval” signaling effect. By contrast, Temasek’s commercially …
How Fe(Ii)/2-Oxoglutarate Oxygenase Chooses Chlorination Over Hydroxylation: Electric Field-Driven Ligand Exchange Governs C-Cl Formation, Simahudeen Bathir Jaber Sathik Rifayee, Midhun George Thomas, Anandhu Krishnan, Kritika Gupta, Carter Davis, Tatyana Karabencheva-Christova, Christo Z. Christov
How Fe(Ii)/2-Oxoglutarate Oxygenase Chooses Chlorination Over Hydroxylation: Electric Field-Driven Ligand Exchange Governs C-Cl Formation, Simahudeen Bathir Jaber Sathik Rifayee, Midhun George Thomas, Anandhu Krishnan, Kritika Gupta, Carter Davis, Tatyana Karabencheva-Christova, Christo Z. Christov
Michigan Tech Publications
Non-heme Fe(II)/2-oxoglutarate (2OG)-dependent halogenases catalyze highly selective C-H halogenation. BesD is a non-heme Fe(II)/2OG halogenase that performs regio- and stereoselective chlorination of the l-lysine (l-Lys) substrate. Understanding the mechanism by which halogenation is favored over canonical hydroxylation is essential for guiding enzyme engineering efforts aimed at converting hydroxylases into halogenases. Here, we combine molecular dynamics (MD) and hybrid quantum mechanics/molecular mechanics (QM/MM) calculations to elucidate the origin of chlorination selectivity in BesD and variants derived from a homologous hydroxylase. Our results indicate that, although the initial inline Cl-Fe(III)-OH intermediate is inherently predisposed toward hydroxylation, it undergoes a two-step isomerization in …