Digital Commons Network^™

Characterization And Individual-Level Prediction Of Cognitive State In The First Year After 'Mild' Stroke, Juan Pablo Saa, Tamara Tse, Gerald Choon-Huat Koh, Philip Yap, Carolyn M. Baum, David E. Uribe-Rivera, Saras M. Windecker, Henry Ma, Stephen M. Davis, Geoffrey A. Donnan, Leeanne M. Carey

2020-Current year OA Pubs

BACKGROUND: Mild stroke affects more than half the stroke population, yet there is limited evidence characterizing cognition over time in this population, especially with predictive approaches applicable at the individual-level. We aimed to identify patterns of recovery and the best combination of demographic, clinical, and lifestyle factors predicting individual-level cognitive state at 3- and 12-months after mild stroke.

METHODS: In this prospective cohort study, the Montreal Cognitive Assessment (MoCA) was administered at 3-7 days, 3- and 12-months post-stroke. Raw changes in MoCA and impairment rates (defined as MoCA<24 points) were compared between assessment time-points. Trajectory clusters were identified using variations of ≥1 point in MoCA scores. To further compare clusters, additional assessments administered at 3- and 12-months were included. Gamma and Quantile mixed-effects regression were used to predict individual MoCA scores over time, using baseline clinical and demographic variables. Model predictions were fitted for each stroke survivor and evaluated using model cross-validation to identify the overall best predictors of cognitive recovery.

RESULTS: Participants' (n = 119) MoCA scores improved from baseline to 3-months …

Trauma Patients Have Reduced Ex Vivo Flow-Dependent Platelet Hemostatic Capacity In A Microfluidic Model Of Vessel Injury, Kimberly A. Thomas, Rassam M. G. Rassam, Ronit Kar, Devin M. Dishong, Katelin C. Rahn, Ricardo Fonseca, Melissa Canas, Jose Aldana, Hussain Afzal, Kelly Bochicchio, Matthew D. Neal, Grant V. Bochicchio, Philip C. Spinella, Susan M. Shea

2020-Current year OA Pubs

Trauma is the leading cause of death in individuals up to 45 years of age. Alterations in platelet function are a critical component of trauma-induced coagulopathy (TIC), yet these changes and the potential resulting dysfunction is incompletely understood. The lack of clinical assays available to explore platelet function in this patient population has hindered detailed understanding of the role of platelets in TIC. The objective of this study was to assess trauma patient ex vivo flow-dependent platelet hemostatic capacity in a microfluidic model. We hypothesized that trauma patients would have flow-regime dependent alterations in platelet function. Blood was collected from …

Interbody Material Composition And Bone Morphogenetic Protein-2—Risks And Benefits Of Utilization: A Narrative Review, Rohit Bhan, Francisco Narro Garcia, Brian J. Neumann, Mark J. Lambrechts

2020-Current year OA Pubs

No abstract provided.

Arid1a Loss Is Associated With Increased Nrf2 Signaling In Human Head And Neck Squamous Cell Carcinomas, Vinh Nguyen, Travis P. Schrank, Michael B. Major, Bernard E. Weissman

2020-Current year OA Pubs

Prior to the next generation sequencing and characterization of the tumor genome landscape, mutations in the SWI/SNF chromatin remodeling complex and the KEAP1-NRF2 signaling pathway were underappreciated. While these two classes of mutations appeared to independently contribute to tumor development, recent reports have demonstrated a mechanistic link between these two regulatory mechanisms in specific cancer types and cell models. In this work, we expand upon these data by exploring the relationship between mutations in BAF and PBAF subunits of the SWI/SNF complex and activation of NRF2 signal transduction across many cancer types. ARID1A/B mutations were strongly associated with NRF2 transcriptional …

Characterization Of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels In Oligodendrocytes., Kyle A Lyman, Ye Han, Andrew P Robinson, Samuel E Weinberg, Daniel W Fisher, Robert J Heuermann, Reagan E Lyman, Dong Kyu Kim, Andreas Ludwig, Navdeep S Chandel, Mark D Does, Stephen D Miller, Dane M Chetkovich

2020-Current year OA Pubs

Mature oligodendrocytes (OLG) are the myelin-forming cells of the central nervous system. Recent work has shown a dynamic role for these cells in the plasticity of neural circuits, leading to a renewed interest in voltage-sensitive currents in OLG. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and their respective current (I

Proceedings Of The 11th Annual Deep Brain Stimulation Think Tank: Pushing The Forefront Of Neuromodulation With Functional Network Mapping, Biomarkers For Adaptive Dbs, Bioethical Dilemmas, Ai-Guided Neuromodulation, And Translational Advancements, Kara A Johnson, Nico U F Dosenbach, Evan M Gordon, Et Al.

2020-Current year OA Pubs

The Deep Brain Stimulation (DBS) Think Tank XI was held on August 9-11, 2023 in Gainesville, Florida with the theme of "Pushing the Forefront of Neuromodulation". The keynote speaker was Dr. Nico Dosenbach from Washington University in St. Louis, Missouri. He presented his research recently published in Nature inn a collaboration with Dr. Evan Gordon to identify and characterize the somato-cognitive action network (SCAN), which has redefined the motor homunculus and has led to new hypotheses about the integrative networks underpinning therapeutic DBS. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers, and …

Post-Traumatic Stress And Future Substance Use Outcomes: Leveraging Antecedent Factors To Stratify Risk, Henri M Garrison-Desany, Stacey L House, Et Al.

2020-Current year OA Pubs

BACKGROUND: Post-traumatic stress disorder (PTSD) and substance use (tobacco, alcohol, and cannabis) are highly comorbid. Many factors affect this relationship, including sociodemographic and psychosocial characteristics, other prior traumas, and physical health. However, few prior studies have investigated this prospectively, examining new substance use and the extent to which a wide range of factors may modify the relationship to PTSD.

METHODS: The Advancing Understanding of RecOvery afteR traumA (AURORA) study is a prospective cohort of adults presenting at emergency departments (N = 2,943). Participants self-reported PTSD symptoms and the frequency and quantity of tobacco, alcohol, and cannabis use at six total …

Modular Horizontal Network Within Mouse Primary Visual Cortex, Andreas Burkhalter, Weiqing Ji, Andrew M Meier, Rinaldo D D'Souza

2020-Current year OA Pubs

Interactions between feedback connections from higher cortical areas and local horizontal connections within primary visual cortex (V1) were shown to play a role in contextual processing in different behavioral states. Layer 1 (L1) is an important part of the underlying network. This cell-sparse layer is a target of feedback and local inputs, and nexus for contacts onto apical dendrites of projection neurons in the layers below. Importantly, L1 is a site for coupling inputs from the outside world with internal information. To determine whether all of these circuit elements overlap in L1, we labeled the horizontal network within mouse V1 …

Recarving The Future: Bridging Car T-Cell Therapy Gaps With Synthetic Biology, Engineering, And Economic Insights, Alaa Ali, John F Dipersio

2020-Current year OA Pubs

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematologic malignancies, offering remarkable remission rates in otherwise refractory conditions. However, its expansion into broader oncological applications faces significant hurdles, including limited efficacy in solid tumors, safety concerns related to toxicity, and logistical challenges in manufacturing and scalability. This review critically examines the latest advancements aimed at overcoming these obstacles, highlighting innovations in CAR T-cell engineering, novel antigen targeting strategies, and improvements in delivery and persistence within the tumor microenvironment. We also discuss the development of allogeneic CAR T cells as off-the-shelf therapies, strategies to mitigate adverse effects, and …

Perspectives Of Traditional Herbal Medicines In Treating Retinitis Pigmentosa, Shihui Liu, Toshihiko Matsuo, Chie Matsuo, Takumi Abe, Jinghua Chen, Chi Sun, Qing Zhao

2020-Current year OA Pubs

Medicinal plants, also known as herbs, have been discovered and utilized in traditional medical practice since prehistoric times. Medicinal plants have been proven rich in thousands of natural products that hold great potential for the development of new drugs. Previously, we reviewed the types of Chinese traditional medicines that a Tang Dynasty monk Jianzhen (Japanese: Ganjin) brought to Japan from China in 742. This article aims to review the origin of Kampo (Japanese traditional medicine), and to present the overview of neurodegenerative diseases and retinitis pigmentosa as well as medicinal plants in some depth. Through the study of medical history …

Centering Intersectional Breast Cancer Screening Experiences Among Black, Latina, And White Women: A Qualitative Analysis, Sienna Ruiz, Kamilah Abdur-Rashid, Rachel L Mintz, Maggie Britton, Ana A Baumann, Graham A Colditz, Ashley J Housten

2020-Current year OA Pubs

OBJECTIVE: Mammography screening guidelines in the United States highlight the importance of informing and involving women when making their breast cancer screening decisions. However, the complexity of interpreting and applying these population-level guidelines can contribute to patient burden. Patient-centered communication strategies can alleviate patient burden, but few consider perspectives from racially and ethnically marginalized populations. We examine diverse women's perspectives on screening to characterize patient-centered experiences.

METHODS: We conducted 28 focus groups with 134 non-Latina Black (

RESULTS: We identified three themes: (1) personal relationships with primary care providers, (2) potential impacts of cancer on families, and (3) interactions with …

Can Micro-Expressions Be Used As A Biomarker For Autism Spectrum Disorder, Mindi Ruan, Na Zhang, Xiangxu Yu, Wenqi Li, Chuanbo Hu, Paula J Webster, Lynn K Paul, Shuo Wang, Xin Li

2020-Current year OA Pubs

INTRODUCTION: Early and accurate diagnosis of autism spectrum disorder (ASD) is crucial for effective intervention, yet it remains a significant challenge due to its complexity and variability. Micro-expressions are rapid, involuntary facial movements indicative of underlying emotional states. It is unknown whether micro-expression can serve as a valid bio-marker for ASD diagnosis.

METHODS: This study introduces a novel machine-learning (ML) framework that advances ASD diagnostics by focusing on facial micro-expressions. We applied cutting-edge algorithms to detect and analyze these micro-expressions from video data, aiming to identify distinctive patterns that could differentiate individuals with ASD from typically developing peers. Our computational …

Cell-Type-Specific Consolidation Of Learned Motor Memories In The Neocortex, Rebecca Dicicco

Harriet L Wilkes Honors College Theses 2020 - Present

Motor learning is crucial for diverse behaviors, yet the neural mechanisms that consolidate the learning remain poorly understood. A recent study (Majumder et al., 2023) found that inhibiting Calcium/calmodulin-dependent protein kinase II (CaMKII) in pyramidal tract (PT) neurons, but not Intratelencephalic (IT) neurons, in the Anterior Lateral Motor cortex (ALM) disrupt motor learning. This suggests a cell-type-specific reliance on CaMKII for inducing synaptic plasticity during motor skill acquisition. This project aims to explore how the brain consolidates the acquired motor skill as a long-term memory. We hypothesize that following motor learning, CaMKII in PT, but not IT, cells activates the …

“Biological Warfare: Can A War Be Justly Fought Using Biological Weapons?”, Gabrielle Emilio Fagundes

Harriet L Wilkes Honors College Theses 2020 - Present

Biological agents and toxins have been used as weapons offensively as early as 1320 BCE. Modern ability to manipulate and control biological materials has raised concerns as to how wars will be fought in the future. The Geneva Protocol of 1925 and the subsequent Geneva Conventions have clearly determined biological warfare as unethical and illegal due to the devastating effects it has on both combatants and noncombatants. The International Humanitarian Laws, based on the fourth Geneva Convention, are used as guidelines for fighting just and legal wars. Although the use of biological weaponry has been banned for almost a century, …

Are Electric Cars Really More Carbon Efficient Than Gasoline Cars?, Aethena Fitzgerald

Harriet L Wilkes Honors College Theses 2020 - Present

Ever since the invention of the wheel, humans have been trying to find faster and more efficient modes of transportation. The evolution from the first horse-drawn carriages to the currently popular electric vehicles marks a big improvement in speed and reliability. Today, modern society relies heavily on cars, the most popular mode of transportation. There are two main classes of automobiles: fossil fuel (gasoline and diesel) and electric. Fossil fuel cars are known for their carbon inefficiency, which leads to large amounts of greenhouse gases being emitted into the Earth’s atmosphere. In recent years, electric vehicles have gained limited popularity …

Elyrion's Harmony: A 2d Video Game, Jovan Fuller

Harriet L Wilkes Honors College Theses 2020 - Present

Elyrion's Harmony' is a 2D side-scrolling game in the fantasy genre. It takes place on the planet Elyrion. Elyrion is home to multiple countries, including Earth, Water, Air, and Fire. The player plays as Lyra, a citizen of Earth who witnesses her village's destruction by the malevolent sorcerer, Malachor. Seeking to tear the world asunder, Malachor's chaos disrupts the once-harmonious planet. As Lyra, players navigate diverse landscapes and battle elemental challenges to save her world.

Mosgraphgen: A Novel Tool To Generate Multi-Omics Signaling Graphs To Facilitate Integrative And Interpretable Graph Ai Model Development, Heming Zhang, Dekang Cao, Zirui Chen, Xiuyuan Zhang, Yixin Chen, Cole Sessions, Carlos Cruchaga, Philip Payne, Guangfu Li, Michael Province, Fuhai Li

2020-Current year OA Pubs

MOTIVATION: Multi-omics data, i.e. genomics, epigenomics, transcriptomics, proteomics, characterize cellular complex signaling systems from multi-level and multi-view and provide a holistic view of complex cellular signaling pathways. However, it remains challenging to integrate and interpret multi-omics data for mining critical biomarkers. Graph AI models have been widely used to analyze graph-structure datasets, and are ideal for integrative multi-omics data analysis because they can naturally integrate and represent multi-omics data as a biologically meaningful multi-level signaling graph and interpret multi-omics data via graph node and edge ranking analysis. Nevertheless, it is nontrivial for graph-AI model developers to pre-analyze multi-omics data and …

Development And Testing Of A Small Wave Energy Converter For Numerical Simulation Validation, Westin Johnson

Harriet L Wilkes Honors College Theses 2020 - Present

Wave energy converters (WECs) are marine renewable energy devices designed to harness the potential and kinetic energy present in waves and convert it into electrical energy. This energy can then be stored or directed to power coastal cities or offshore installations. This thesis discusses a small-scale (~2m diameter) wave energy converter developed to gather open-water performance data for validating the numerical simulation of a 4-body oscillating body type WEC design. This WEC underwent numerical simulation using both WEC-Sim and ProteusDS, and these results were subsequently compared to the in-water testing data to validate the accuracy of the simulation. This research …

The Enigma Of The Successful Psychopath: An In-Depth Examination, Josette Mobley

Harriet L Wilkes Honors College Theses 2020 - Present

In this thesis, I examine three psychological characteristics – psychopathy, autism, and intelligence – and consider how they are related. Psychopathy is a condition that has long captured the public imagination. Articles and blogs are devoted to murderers with psychopathic features. Movies and TV shows have been based on real-life famous psychopaths narrating the horrible crimes they have committed. Psychopathy is a personality disorder characterized by a lack of empathy and guilt, manipulation of other people, and violent antisocial behavior. Intelligence is the ability to acquire and apply knowledge and skills. “Successful psychopaths” are those who have all the traits …

Invictus: Nigredo & Calcinatio, Christian Soares Deoliveira

Harriet L Wilkes Honors College Theses 2020 - Present

Invictus is a narrative virtual reality (VR) game which makes use of 16th century alchemical concepts on becoming spiritually whole. As an alchemist, the player begins their first steps in achieving The Great Work – a state of perfect being; synonymous with creating The Philosopher’s Stone. To begin, players embark into a stage called Nigredo, where the many is transmuted into one through the processes of alchemical Fire – calcination – as a method of purification. Players begin in an alchemical laboratory, learning about and preparing the first stage and process. To experience being transmuted by the power of Fire, …

Could Solar Energy Be Our Future? Literary Analysis, Tyler Martin

Harriet L Wilkes Honors College Theses 2020 - Present

As energy consumption increases, the need for an efficient, cheap-to-make, and low-maintenance power converter is increasingly sought after. Solar energy has the potential to fill all these requirements as it is not only the most abundant source of energy on the planet, but the devices themselves require little to no cost post-installation. Solar cells convert photon particles into flowing current, producing voltage by merely remaining stationary, something that fossil fuel production cannot achieve. The efficiency of these devices has drastically improved over the last 30 years, jumping from less than 10% to nearly 30%, and with some of the practices …

From Fast Fashion To Slow Fashion, Grace Xiong

Harriet L Wilkes Honors College Theses 2020 - Present

Fast fashion is an industry that capitalizes on the ever quick and changing fashion trends of our society. To keep up with the demand, many fast fashion corporations find themselves adopting certain practices that have generated a significant amount of environmental and social concerns. However, in a society that endorses the constant grooming of oneself into an image that fits the look of a particular group, corporations are not willing to let this opportunity for great profit go to waste. This paper will first examine the effects of the fashion industry on the environment in general, analyze the ideas of …

Investigating Preservice Secondary Teachers’ Understanding And Enactment Of The Standards‑Based Practices During Microteaching, Deepika Menon, Diana S. Chang, Rosetta W. Ngugi

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Reform efforts in K–12 science education have been gaining pace ever since the introduction of the Next Generation Science Standards (NGSS). The new vision calls for reconsidering teacher preparation programs to prepare future teachers who are confident and competent in delivering NGSS-based instruction. This study investigated the development of 27 preservice secondary science and mathematics teachers’ (PSTs’) knowledge and skills as they understand, interpret, and implement the NGSS, particularly science and engineering practices (SEPs), within the context of microteaching during a STEM methods course. Primary data sources include 12 videos of 40-minute-long microteaching lessons, self-reflections, semistructured and focus-group interviews, and …

Critical Dialogue And Capacity-Building Projects Reduced Alcohol And Substance Use In A Randomized Clinical Trial Among Formerly Incarcerated Men, Alexis Jemal, Kari Kugler, Douglas C Smith, Rogério M Pinto, Salma Musaad

Faculty, Staff and Students Publications

Background:

Rates of alcohol and/or substance use (ASU) among residents of predominantly Black and marginalized communities are similar to ASU rates in White communities. Yet ASU has worse consequences in predominantly Black and marginalized communities (e.g., higher incarceration).

Objective:

We randomized participants to one of 16 intervention conditions using a 2⁴ full factorial design to optimize a multilevel intervention reducing ASU among 602 formerly incarcerated men with substance-use-disorders (SUD). Candidate intervention components included (1) critical dialogue (CD; six weekly 2-hour-long group sessions vs. no CD sessions), (2) Quality of Life Wheel (QLW; six weekly 1-hour-long group sessions vs. no …

The Effectiveness Of Resistance Exercises Performed On Stable And Unstable Surfaces In Relation To Torso Activation, Radim Jebavy, Dusan Blazek, Helena Vomackova, Jan Vavra, Jan Busta, Anna Pisz, Petr Stastny

Baltic Journal of Health and Physical Activity

Introduction: Deep stabilization system (DSS) strength and endurance are crucial for injury prevention and athletic performance. Training surfaces can influence training outcomes; therefore, this study aimed to compare the impact of performing strength trunk exercises on unstable and stable surfaces with conventional trunk exercises. Materials and Methods: DSS and trunk stability were assessed before and after 10 weeks of three different training interventions among twenty elite futsal players. Each intervention included 25 strength training sessions. Pre- and post-tests encompassed various measurements, including diaphragm, trunk flexion, trunk back extension, hip flexion, intraabdominal pressure, side plank, pronation, and supination tests. Results: Conventional …

Application Of Augmented Reality (Ar) In Vocational Education: A Systematic Literature Review, Supriyanto Supriyanto, Quienera Joshua, Ade Gafar Abdullah, Emmanuel Obobi Tettehfio, Sulaeman Deni Ramdani

Jurnal Pendidikan Vokasi

Augmented Reality (AR) is a technology that combines two-dimensional and or three-dimensional virtual objects into a real environment and then projects these virtual objects in reality in real time. Through this AR technology, users can see virtual objects added to the real world with contextual information. In education, AR has been widely used to complement the standard curriculum. Text, graphics, video, and audio can be superimposed into the student's real-time environment. This article aims to examine how the application and impact of the use of AR in vocational education. The Systematic Literature Review (SLR) method is used to identify, study, …

Breaking Down Computer Networking Instructional Videos: Automatic Summarization With Video Attributes And Language Models, Totok Sukardiyono, Muhammad Irfan Luthfi, Nisa Dwi Septiyanti

Elinvo (Electronics, Informatics, and Vocational Education)

Instructional videos have become a popular tool for teaching complex topics in computer networking. However, these videos can often be lengthy and time-consuming, making it difficult for learners to obtain the key information they need. In this study, we propose an approach that leverages automatic summarization and language models to generate concise and informative summaries of instructional videos. To enhance the performance of the summarization algorithm, we also incorporate video attributes that provide contextual information about the video content. Using a dataset of computer networking tutorials, we evaluate the effectiveness of the proposed method and show that it significantly improves …

The Evaluation Of Village Building Program/Thematic Real Work Lecture (Kknt) Mbkm's Implementation At Uin Sunan Kalijaga, Muyassaroh Muyassaroh, Sudiyatno Sudiyatno, Nur Hidayanto Pancoro Setyo Putro, Rahma Yunita, Syafiqurrahman Syafiqurrahman

Jurnal Penelitian dan Evaluasi Pendidikan

This study aims to determine the standards of MBKM Thematic KKN, how the implementation of this program at UIN Sunan Kalijaga, as well as to determine the gap between the existing standards and the form of implementation. This evaluation research uses the descrepancy evaluation model with a descriptive qualitative approach. Data collection in this study used interview techniques, documentation, and was equipped with an open questionnaire. The data sources in this study at the interview stage were 7 resource persons 1 Head of PPM UIN Sunan Kalijaga, 2 Field Supervisor (DPL), 2 heads of Study Programs and 2 students, as …

Factor Analysis Of The Relationship Of Curiosity And Device Addiction Through Motivation To Digital Literacy In The Context Of Smart Learning, Yeka Hendriyani, Muhammad Anwar, Hendra Hidayat, Elsa Sabrina, Pardjono Pardjono, Erni Marlina Sari

Jurnal Pendidikan Vokasi

This study aims to investigate the relationship between curiosity and device addiction factors and motivation towards digital literacy in the context of smart learning. This study used a qualitative approach involving 228 students majoring in Electronics Engineering Education at Universitas Negeri Padang. Data were collected through a Likert-scale questionnaire with a saturated sampling method, ensuring all relevant respondents were involved. To evaluate the measurement model of the research questions, Structural Equation Modeling (SEM) analysis was used. The results revealed that digital literacy is significantly influenced by three main factors: curiosity, gadget addiction and app addiction. Furthermore, the study found that …

Comparison Of Convolutional Neural Network Architecture On Detection Of Helmet Use By Humans, H. Hartatik, Muhammad Khoirul Anam

Elinvo (Electronics, Informatics, and Vocational Education)

The helmet is one of the protective equipment for the head when driving. Although it is a protector, some criminals misuse helmets to disguise their identities, such as robbery at ATMs. Some places have put a sticker not to wear a helmet in the ATM room. However, this advice is often violated. The research adopted the Convolutional Neural Network (CNN) algorithm to identify humans who use helmets and do not use helmets based on digital images. Several CNN models, such as MobileNet-V2, ResNet-50, and VGG-16, were compared in performance. The experiment was carried out using a dataset consisting of 3,207 …