Digital Commons Network^™

Polycationic Nanoparticle Delivery Of Nucleic Acids For The Treatment Of Fibrosis In Alcohol-Associated Liver Diseases, Chuhan Zhang

Theses & Dissertations

Alcohol-associated liver disease (AALD) is a major cause of liver disorders worldwide. Current treatment options are limited, especially for AALD-related fibrosis. Targeted therapies are urgently needed for severe forms of AALD. In my project, dual-functioning nanoparticles for the effective delivery of antifibrotic RNA were designed and developed, together with combined CXCR4 inhibition or CD44 targeting as a way to improve the treatment of AALD fibrosis. An alcoholic fibrosis model of moderate alcohol consumption with secondary liver insult was built for evaluation of nanoparticle performance in vivo. In Chapter 2, a cholesterol-modified polymeric CXCR4 inhibitor (Chol-PCX) was synthesized and used to …

Privacy Lost: How The Montana Supreme Court Undercuts The Right Of Privacy, Kevin Frazier

Seattle Journal of Technology, Environmental, & Innovation Law

In 1972, Montanans ratified a new constitution that included a “right of privacy.” The plain text of the provision fails to express the intent of the Framers who not only intended to afford Montanans a right, but also to impose a responsibility on the State to continuously and thoroughly examine State practices in light of evolving means of invading residents’ privacy. This intent has gone unrealized despite the fact that the intent of the Framers is clear, readily available, and the primary source state courts ought to use when interpreting the Constitution. This article delves into the transcripts of the …

Conviction On Interpretation, Advocate Adaptability, And The Future Of Emojis And Emoticons As Evidence, Samantha Lyons

Seattle Journal of Technology, Environmental, & Innovation Law

The dawning of the digital age introduced new and unique interpretive quandaries for judges and litigators alike. These quandaries include (but are not limited to) misinterpretation of pictorial slang as used in instant messaging, new or collateral meanings invented by phrases paired with specific emoticons or emojis, and the existence of emojis alone as communicative accessories.

This Note analyzes how lawyers and judges have essential free reign to treat emojis as they see fit: a prosecutor can argue, even in good faith, that the inclusion of an emoji depicting an open flame means the sender knew the heroin he sold …

From Hashtag To Hash Value: Using The Hash Value Model To Report Child Sex Abuse Material, Jessica Mcgarvie

Seattle Journal of Technology, Environmental, & Innovation Law

In the summer of 2021, Apple announced it would release a Child Safety Feature (CSF) aimed at reducing Child Sex Abuse Materials (CSAM) on its platform. The CSF would scan all images a user uploaded to their iCloud for CSAM, and Apple would report an account with 30 or more flagged images to the National Center for Missing and Exploited Children. Despite Apple’s good intentions, they received intense backlash, with many critics arguing the proposed CSF eroded a user’s privacy. This article explores the technology behind Apple’s CSF and compares it to similar features used by other prominent tech companies. …

A New Right Is The Wrong Tactic: Bring Legal Actions Against States For Internet Shutdowns Instead Of Working Towards A Human Right To The Internet (Part 1), Jay Conrad

Seattle Journal of Technology, Environmental, & Innovation Law

A New Right is the Wrong Tactic: Bring Legal Actions Against States for Internet Shutdowns Instead of Working Towards a Human Right to the Internet (Part 1) is the first of a two-part series dealing with an increasingly prevalent threat to human rights: State-sanctioned Internet shutdowns. Part 1 details the current tactics and impacts of Internet shutdowns and which human rights are most likely to be violated by or during a shutdown. Part 2 will address the deficiencies of advocating for Internet access to be a recognized human right as a means of combatting shutdowns. Despite the popularity of this …

Macro And Micro-Nutrient Accumulation And Partitioning In Soybean Affected By Water And Nitrogen Supply, Ingrid Silva Setubal, Aderson Soares De Andrade Júnior, Silvestre Paulino Da Silva, Artenisa Cerqueira Rodrigues, Aurenívia Bonifácio, Evandro Henrique Figueiredo Moura Da Silva, Paulo Fernando De Melo Jorge Vieira, Rafael De Souza Miranda, Nicolas Cafaro La Menza, Henrique Antunes De Souza

West Central Research and Extension Center, North Platte

This study aimed to investigate the influence of water availability and nitrogen fertilization on plant growth, nutrient dynamics, and variables related to soybean crop yield. Trials were performed in Teresina, Piauí, Brazil, using randomized blocks in a split-split plot arrangement. The plots corresponded to water regimes (full and deficient), the split plots to N fertilization (0 and 1000 kg ha^-1 N-urea), and the split-split plots to harvest times of soybean plants (16, 23, 30, 37, 44, 58, 65, 79 and 86 days after emergence), with three replicates. In general, the accumulation and partitioning of nitrogen (N), phosphorus (P), potassium …

Targeting The Cxcr1/2 Axis In Pancreatic Ductal Adenocarcinoma, Caitlin Molczyk

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is notoriously challenging to diagnose and treat. This tumor has an aggressive phenotype and benign clinical features until severe disease dissemination, which makes it too late to eradicate. Although it is only the 10th most common cancer in the United States, it is the fourth leading cause of cancer-related deaths. The treatment options are complicated further due to tumor heterogeneity, meaning not all tumor cells are in the same state phenotypically or epigenetically. They also express cytokines, chemokines, and receptors differently. Here we explore the usage of CXCR1 and CXCR2 and their ligands in PDAC tumor …

Routing Battery-Constrained Delivery Drones In A Depot Network: A Business Model And Its Optimization-Simulation Assessment, Yanchao Liu

Industrial and Systems Engineering Faculty Research Publications

This paper proposes a novel business model for on-demand package shipment services using drones, and evaluates different modeling and solution approaches for the drone routing problem that underpins the service operation. In the proposed service, customers’ shipment orders of arbitrary origins and destinations, payload weights and bid values are collected every five minutes, and available drones from multiple depots are then dispatched to fulfill a subset of these orders in a way to maximize profit. A drone path starts from a depot, serves one or more customer orders in sequence, and ends at a depot for battery recharging, which incurs …

Targeted Therapies For Improving The Treatment Of Sonic Hedgehog And Myc Driven Medulloblastoma, Bharti Sethi

Theses & Dissertations

The aim of this thesis to develop a novel potent dual inhibitor to target BDR4/PI3K and MDM2/ XIAP pathways to treat medulloblastoma. A series of new analogs were synthesized, characterized, and evaluated in vitro and in vivo using xenograft and orthotopic mouse models.

In Chapter 1 an overview of Blood brain barrier such as their components, physiology, current drug delivery system and nanomedicines to treat medulloblastoma.

Chapter 2 includes synthesis of new molecule MDP5, targeting both BRD4 and PI3K pathways. We used X-ray crystal structures and molecular modeling approach to confirm the interactions between MDP5 with BD domains from both …

Mntnbuoe-2-Pyp Sensitizes Castrate Resistant Prostate Cancer To Androgen Deprivation Therapies, Ariel Moats

Theses & Dissertations

Prostate cancer is the second leading cause of cancer related deaths in men in the United States. Treatment for prostate cancer, such as androgen deprivation therapy, radiation, and surgery are effective until resistant cells arise and develop castration resistant prostate cancer (CRPC). CRPC is often difficult to treat due to androgen-independent signaling and growth. Here we target the altered redox balance in prostate cancer with MnTnBuOE-2-PyP (BuOE), a superoxide dismutase (SOD) mimic and ADT treatments. We investigated prostate cancer growth with BuOE and multiple ADT treatments in CRPC cell line models, C42B and 22Rv1. Our results show BuOE and ADT …

Evaluating The Impact Of Routine Enteral Iron Fortification On Gastrointestinal Dysbiosis In Premature Infants, Matthew Van Ormer

Theses & Dissertations

The gastrointestinal microbiome in preterm infants bears significant influence on optimal outcomes – dysbiosis is shown to substantially increase the risk of the life-threatening necrotizing enterocolitis, whereas optimal microbiome composition improves nutrient digestion and immune function. Iron is a vital nutrient especially during the perinatal window of rapid hemoglobin production, tissue growth, and foundational neurological development. However, excess colonic iron exhibits potent oxidation capacity and alters the competitive environment of microbes – potentially facilitating the proliferation of pathological bacterial strains in the gut. Of note, breastfed preterm infants routinely receive iron fortification starting at 14 days of life and are …

Mechanisms Of Mutated Myosin Vb Mediated Cholestasis In Microvillus Inclusion Disease, Melissa S. Holzapfel

Theses & Dissertations

Microvillus inclusion disease (MVID) is a constitutive intestinal epithelial disease which causes definitive intestinal failure and cholestatic liver disease primarily caused by mutations in the Myosin Vb gene. Genotype-clinical phenotype associations suggest that the progression of liver disease can be predicted through a correlation between myosin Vb residual function and variable retention of bile salt transport machinery in intestinal enterocytes and liver hepatocytes. We proposed that aberrant distribution of bile salt transport proteins disrupts enterohepatic regulation of bile acids and contributes to the progression of cholestatic liver disease. To investigate the genotype-phenotype correlation, samples from MVID patients were evaluated for …

Occupational Therapy's Role In Helping Individuals In The Us Justice System Transition From Incarceration To The Community, Kathryn E. Foster

Occupational Therapy Capstone Presentations

Individuals with cognitive disabilities face unique challenges in their transition and integration from prison settings. Occupational therapy offers tailored, client-centered reentry services to address their needs and the evidence on impact is limited. The purpose of this project was to examine the efficacy of strengths-based, occupational therapy-led reentry services on the reentry of individuals on probation and parole with a cognitive challenge into society following incarceration. I used a retrospective, mixed methods design to complete this project. Community-based reentry services were provided post-release in the local St. Louis community. Participants included both occupational therapy practitioners tracking process and impact measures, …

Assessing Gender Differences In Usd Students In The Consumption Of Pornography, Abbey Selleck

Honors Thesis

While pornography consumption has been studied many times in the past decade, little has been done on assessing the gender differences behind it. This study sought out to find those differences. A total of 306 University of South Dakota students participated in an online pornography survey. There was 231 females and 75 males. When asked about intentionally consuming pornography, there was 241 responses, 180 females and 61 males. Of those responses, 57 males (93%) and 142 females (79%) said they intentionally consume pornography. As hypothesized, a higher percentage of men said they consumed porn regularly (34%) than did women (4%). …

Cystic Duct Morphology And Heister Valves: A Cadaveric Study, Cierra R. Goerish

Theses & Dissertations

Continued occurrence of cholelithiasis, gallstones, commonly results in cholecystectomy, removal of the gallbladder. Having a comprehensive anatomical, histological, and physiological knowledge of the biliary apparatus is imperative in clinical medicine today. Additionally, the functionality of cystic duct (CD) Heister valves (HV) has been speculatory since being reported in 1732. This study summarizes the morphology, orientation, and variability of the gross biliary system and provides data to help justify HV functionality.

Cadaveric dissection was utilized for gross observation and analysis of the biliary system. The angulation of the CD was found primarily as an acute angle; however, obtuse angulation could be …

Doctor Of Medicine Commencement: May 6, 2023, University Of North Dakota

UND Commencement Programs

UND Doctor of Medicine Commencement program from May 6, 2023.

School Of Law Commencement: May 6, 2023, University Of North Dakota

UND Commencement Programs

UND School of Law Commencement program from May 6, 2023.

Vulnerability Of Juveniles To False Confessions, Amanda Ghibaudo

Undergraduate Honors Theses

In criminal proceedings, confessions have long been recognized as the gold standard of evidence. Understandably, many people question why someone would willingly confess to a crime that they did not commit. However, in the event of an interrogation, police often use psychologically coercive interrogation techniques that may make suspects, especially juveniles, more susceptible to false confessions. This paper intends to assess the vulnerability of juveniles to false confessions and the legal implications of such confessions. The reality is that false confessions ruin innocent lives. Synthesizing existing literature on relevant U.S. Supreme Court cases, juvenile interrogation procedures, and the dispositional vulnerabilities …

The History Of Wrongful Birth And The Future Of Reproductive Technologies, Luke Isaac Haqq

Minnesota Journal of Law, Science & Technology

No abstract provided.

The Brain On Death Row: Reconciling Neuroscience & Categorical Exemptions From Execution, Alexa Johnson-Gomez

Minnesota Journal of Law, Science & Technology

No abstract provided.

The Health Care Industry Is Ready For A Revolution: Its Privacy Laws Are Not, Erin Rutherford

Minnesota Journal of Law, Science & Technology

No abstract provided.

To Hear Or Not To Hear: How “Best Interest” Determinations Can Help In The Cochlear Implant Debate, Tessa Wright

Minnesota Journal of Law, Science & Technology

No abstract provided.

Implementation Of A Nurse-Led Clinical Algorithm For Pressure Injury Prevention Associated With Non-Invasive Ventilation Medical Device Use, Capri Steinkuhler, Kaitlin Rogge

Doctor of Nursing Practice Projects: College of Nursing

Purpose and Aims

Medical device related pressure injuries (PI) account for as much as 61-81% of all hospital reported wound incidents (Gefen et al., 2020) and are frequently caused by respiratory devices such as non-invasive ventilation (NIV). Use of NIV in critically ill patients dramatically increased during the pandemic. PI are one of the leading causes of injury to hospitalized patients and lengthens hospital stays (National Pressure Injury Advisory Panel [NPIAP], 2019). The NPIAP recommends routine skin assessment under devices, proper mask fit, protective barrier, moisture reduction, and interdisciplinary collaboration to prevent PIs from NIV masks. This feasibility study’s purpose …

2022 Spectrum Policy Initiative Conference Outcomes Report, Braham Stevenson, Jackson Mcneal, Sean Harms, Xelef Botan

Colorado Technology Law Journal

No abstract provided.

The Exacerbating Role Of Technological And Connectivity Challenges On Older Detroiters’ Health In A Pandemic, Nicholas Schroeck, Carrie Leach

Seattle Journal of Technology, Environmental, & Innovation Law

The COVID-19 pandemic hit communities of color hard. The City of Detroit was particularly vulnerable to COVID-19 due to racial, socioeconomic, and environmental health factors. To analyze the exacerbating role of technology and connectivity challenges on older Detroiters' health in a pandemic, we first examined Detroit’s demographics. This analysis involved looking at the continued evolution of the City's population toward older adults, as well as the impact of COVID-19 and the healthcare services on Detroit’s elder population. Next, we examined Detroit’s internet access challenges, including the presence of digital exclusion among older adults in Detroit, the impact of COVID-19 on …

Indo-Pacific Conflicts Will Be Reimagined In Outer Space Exploration, Michael Incorvaia

Seattle Journal of Technology, Environmental, & Innovation Law

This article will focus on the effects of international treaties and how they can be utilized to govern the future of outer space exploration. The discussion will include evaluating how modern changes in technology have created a need for updated outer space-specific treaties to ensure that outer space does not become a contentious zone between countries. This article will begin by exploring the developments in outer space that have created a new space race. Then, it will discuss the Indo-Pacific conflict and why the current multilateral treaty strategy that is used in the region will not be effective in outer …

A Brief Review Of Selected Research-Based Strategies For Helping Young Singers Match Pitch, Dirk Myers

Electronic Theses & Dissertations

The purpose of this review of literature was to identify ways to help varying levels of novice singers manage and improve their vocal pitch matching ability. The review identified the work of prominent pedagogues and researchers. The literature review revealed that techniques aiding the novice singer yield varying levels of success. Most of the research showed that remedial techniques work best in small groups, one-on-one settings, and solo singing. The research did not address the issue of effective teaching and its effect with regard to student achievement (e.g., classroom management and issues related to effective or ineffective teaching ability).

The Great Unlearning, Catherine Mccrory Pears

Electronic Theses and Dissertations

The Great Unlearning is a conceptual exploration: sifting through experiences and objects to overcome psychological pain, expectations of society, individual upbringing, and outside influences in an ongoing quest for authenticity. To both embrace personal history and honor loved ones while letting go of lingering negativity is challenging. Using objects culled from my life, examining the past, and incorporating items gathered along my path through nature, the work seeks personal healing while promoting the power of all people to break from indoctrination, group think, and mob mentality to make better choices to live a satisfying and peaceful existence…hopefully in a democratic …

Framework For Applicability Of Fidic Red Book (1999) For Contracts Governed By Law No. 182 Of The Year 2018 For Regulating Contracts Concluded By Public Entities, Fredy Ayad

Theses and Dissertations

An administrative contract is a type of contract that the administrative body enters in order to achieve a public interest. In Egypt, administrative contracts are governed by Law No. 182 of the year 2018 for Regulating Contracts concluded by Public Entities, which has been promulgated in October 2018. This Law includes several mandatory rules, which will govern over any conditions in the construction contract.

The FIDIC Red Book 1999 is widely used in Egypt and the Middle East in private sector and is currently also being utilized by governmental bodies. However, some contractors are not aware of the major deviations …

Channel Island Foxes (Urocyon Littoralis) Are Viable Seed Dispersal Agents Of Toyon, Savannah L. Bartel, Juliann T. Schamel, Bridget A. Parrino, Melissa K. Marshall, John L. Orrock

Western North American Naturalist

Mammals that consume fleshy fruit and deposit viable seeds in their scat can be important agents of seed dispersal for plants. Despite the knowledge that the island fox (Urocyon littoralis) consumes large quantities of fleshy fruits, it is unknown whether seeds survive digestion by island foxes and are able to germinate. In order to evaluate whether island foxes are agents of viable seed dispersal on the Channel Islands, we collected island fox scat on Santa Cruz Island in February 2021 and conducted germination assays on digested seeds found in scat. We compared the germinability and germination rates of …