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Continuous Bioprocessing: Technology For Next-Generation Biopharmaceutical Manufacturing Development Of A Python-Coded Bench-Scale Raman-Based Continuous Bioprocess Platform, Christine Urrea

KGI Theses and Dissertations

Current industrial practices for producing biopharmaceuticals include fed-batch production with batch isolation and purification. Nonproductive hold-up steps and manual offline measurements are common in batch processing which increases processing time and contributes to a high cost of production. Current market trends and cost pressures in the biopharmaceutical industry are creating a push to innovate bioprocessing platforms. Continuous bioprocessing has been considered a solution to the current limitations of batch production of biopharmaceuticals. Continuous bioprocessing involves intensifying individual processing steps by eliminating hold-up steps through a continuous operation to increase productivity, which results in advantages such as lower capital and production …

Impact Of Emotional Processing On Working Memory In Preadolescents With High Autistic And Anxiety Traits, Teagan Mullins

Psychology ETDs

Adolescence is an important neurodevelopmental period that confers both opportunity for positive change, and a risk for emerging psychopathology. In particular, anxiety disorders and autism spectrum disorder (ASD) both cause significant challenges during adolescence that impact individuals throughout their lifespan. Notably, functional impacts of anxiety and ASD are not limited to those who meet diagnostic criteria, and can be present at sub-clinical levels. However, despite high rates of co-morbidity of ASD and anxiety symptomology, the degree to which the neural bases of anxiety are similar or qualitatively different in individuals with and without autistic traits is unknown. One candidate neurobehavioral …

Journey With A Purpose, Walter Prescher

Doctor of Ministry Projects and Theses

The modern church is in bondage from years of trauma rooted in the Post-Christendom decline. As the church has responded to the trauma it is enduring, it has responded by becoming stagnant as it seeks to maintain any relevance it still has. What the modern church is going through has strong parallels with the Hebrew people who were in bondage in Egypt and were delivered through the wilderness into the promised land of Canaan. Following this example, this dissertation walks church leadership through an understanding of the traumatized church and presents a what a modern-day Exodus journey could look like …

"Prodigals Of Traitors: American Pows During The Korean War, Brainwashing, And National Security", Brett Fearer

History Theses and Dissertations

American prisoners of war (POW) in Korea endured unimaginable hardship and pain while in captivity. American POWs suffered through long marches through the freezing mountains of Korea, were given little food or medical attention, and were sometimes executed on the spot when captured. Upon reaching the permanent POW camps along the Yalu River, POWs encountered a new challenge: Communist indoctrination. When the war ended, twenty-one American POWs chose to stay behind with their Chinese captors instead of returning. Additionally, American POWs were accused of collaborating with the enemy, and some military officials and journalists were suspicious of some POWs having …

A Southern People: The Choctaw Nation From Removal Through The Civil War, Josh Phillips

History Theses and Dissertations

While scholars have begun in recent years to give more attention to the Civil War in the Trans-Mississippi region (including the Indian Territory), few have attempted to provide nuanced and comprehensive explanations for the actions of native peoples who took part in the conflict. While the pre-removal era of Choctaw history has received copious attention, the thirty years between removal and the Civil War have received only sparse examination. Historians who have written about this period have typically either gone into very little detail about why the Choctaws sided with the Confederacy or they have identified only one or two …

2023 Spring Commencement Program For The University Of Arkansas At Little Rock., University Of Arkansas At Little Rock. Records And Registration

Commencement Programs

No abstract provided.

The Railsplitter And The Pathfinder: The Relationship Between Abraham Lincoln And John C. Frémont, Kourtney Yantis

Electronic Theses & Dissertations

This study serves as an analysis of the connections between Abraham Lincoln as President of the United States and John Charles Frémont as a Civil War general. Lincoln’s position within history is solid, unlike that of John C. Frémont. The thesis will elevate Frémont to a higher status as a historical figure by arguing that the emancipation edict that he issued for Missouri in August of 1861 would influence Abraham Lincoln’s preliminary emancipation proclamation of September 1862, even though Lincoln repealed Frémont’s decree. In biographies of each man, their interactions are merely a small part of the stories of their …

A Mechanics-Based Analytical Solution For Restrained Beams With Application To Progressive Collapse Behavior, Leven Deputy

Civil and Environmental Engineering Theses and Dissertations

This dissertation presents an axially restrained beam (ARB) model that incorporates axial-flexural interaction throughout the entire static load-deflection curve: the elastic material range, the plastic, flexural dominant range, the range beyond plastic flexure with increasing catenary effect, and the full catenary range. Energy methods are applied to static load-deflection curves to determine dynamic load-deflection relationships. Specifically, this dissertation considers the two conditions; Pinned-Pinned-Pinned (PPP) which has no flexural resistance at the boundaries, and Fixed-Fixed-Fixed FFF (also Pinned-Fixed-Pinned, PFP) condition which provides the beam with flexural resistance at the boundaries equal to flexural capacity of the beam. Behavior is explained analytically …

The Mechanization Of Humanity, Joshua Lipe

Research Papers

No abstract provided.

Protein Dynamics In Allostery And Computer-Aided Drug Design, Mayar Mohamed

Chemistry Theses and Dissertations

Molecular dynamics (MD) simulation is a powerful and versatile computational tool, that can be used in a wide range of applications from studying complex biological processes such as allostery to investigating the process of the protein-ligand binding in different computer-aided drug design implementations. In this work, various structural and drug discovery projects were performed by combining the state-of-art techniques molecular dynamics simulations, virtual screening, and binding free energy calculations with the innovative Markov State Model analysis and the machine learning techniques.

In the first project, the role of A’a helix as a key player in the transition between the light …

Eudaimonist Exemplarism And Saints, Brian C. Clark

Religious Studies Theses and Dissertations

Contemporary moral philosophy tends to treat saints as either maximally moral and thus exemplary only for those who share their ideals or as so morally excellent that they are inimitable and “Other.” Thus, the saint is practically useless as a model for plain persons. Moreover, in the case of Christian saints, modern moral theories tend not to account for their religious and theological dimensions. As a remedy, this dissertation argues for thinking about the exemplarity of saints in eudaimonist and theologically naturalist terms. Christian saints exemplify what Christians consider human flourishing, revising natural accounts of human flourishing but preserving the …

Educating A Denomination: Albert C. Outler And American Theological Education, 1925 - 1974, Lane Davis

Religious Studies Theses and Dissertations

This dissertation provides a critical biography of Albert C. Outler, a prominent historian and theologian in modern Methodism and analyzes three significant emphases in his work: ecumenism, theology and psychology, and Methodist doctrine. The study begins with Outler's formative education and his ministry as a Methodist pastor in Georgia. Outler's doctoral education at Yale focused his work on discovering the connections of the "common history" of all Christians. The study then considers Outler’s extensive work in three interconnected disciplines: ecumenical studies, the study of religion and psychology, and Methodist theology and doctrine. The connection between these diverse subjects lies in …

Optimizing Tumor Xenograft Experiments Using Bayesian Linear And Nonlinear Mixed Modelling And Reinforcement Learning, Mary Lena Bleile

Statistical Science Theses and Dissertations

Tumor xenograft experiments are a popular tool of cancer biology research. In a typical such experiment, one implants a set of animals with an aliquot of the human tumor of interest, applies various treatments of interest, and observes the subsequent response. Efficient analysis of the data from these experiments is therefore of utmost importance. This dissertation proposes three methods for optimizing cancer treatment and data analysis in the tumor xenograft context. The first of these is applicable to tumor xenograft experiments in general, and the second two seek to optimize the combination of radiotherapy with immunotherapy in the tumor xenograft …

Modeling And Characterization Of Cmos Logic Gates Under Large Signal Rf Injection, Zahra Abedi

Electrical and Computer Engineering ETDs

This research addresses the issue of electromagnetic interference (EMI) in digital electronics, which can cause undesired behavior in active electronic components and systems. As technology advances and transistor size decreases, devices become more susceptible to EMI. In addition, as voltage is scaled down to save energy, silicon chips become more susceptible to soft errors. While there are several ways to mitigate the impact of severe EMI on digital systems, minimal electromagnetic coupling can still cause significant problems. We develop analytical models to predict device upset due to EMI. The study focuses on identifying vulnerable parameters of operation related to device …

Black Women Can Jump: The Untold Stories Of Black Women In Higer Education, Jennifer Jones

Education Policy and Leadership Theses and Dissertations

Black women have been a part of American Higher education for over a century (Gregory, 2002). Black women have encountered professional and personal barriers, yet they have made significant advances. Black faculty and administrators have juggled family and community responsibilities, and research state that Black women have more degrees than any group in the United States. However, they seem almost invisible in colleges and universities (Okoli, et al., 2020). Research also suggests disparities for Black women faculty in higher education compared to their white counterparts in tenure, pay, and rank. “Black female administrators in white academe are an endangered species. …

Lipoxin A4 (Lxa4) Reduces Alkali-Induced Corneal Inflammation And Neovascularization And Upregulates A Repair Transcriptome, Jiucheng He, Thang L. Pham, Azucena H. Kakazu, Abhilash Ponnath, Khanh V. Do, Haydee E.P. Bazan

School of Graduate Studies Faculty Publications

Purpose: To investigate the anti-inflammatory and anti-angiogenic effects of the bioactive lipid mediator LXA4 on a rat model of severe corneal alkali injury. Methods: To induce a corneal alkali injury in the right eyes of anesthetized Sprague Dawley rats. They were injured with a Φ 4 mm filter paper disc soaked in 1 N NaOH placed on the center of the cornea. After injury, the rats were treated topically with LXA4 (65 ng/20 μL) or vehicle three times a day for 14 days. Corneal opacity, neovascularization (NV), and hyphema were recorded and evaluated in a blind manner. Pro-inflammatory cytokine expression …

Child Soldiers & Juveniles In Gangs: Opposite Sides Of The Same Coin With Dissimilar Legal Liabilities In International And American Constitutional Law, Jason Blevins

Master's Theses

No abstract provided.

Visualized Algorithm Engineering On Two Graph Partitioning Problems, Zizhen Chen

Computer Science and Engineering Theses and Dissertations

Concepts of graph theory are frequently used by computer scientists as abstractions when modeling a problem. Partitioning a graph (or a network) into smaller parts is one of the fundamental algorithmic operations that plays a key role in classifying and clustering. Since the early 1970s, graph partitioning rapidly expanded for applications in wide areas. It applies in both engineering applications, as well as research. Current technology generates massive data (“Big Data”) from business interactions and social exchanges, so high-performance algorithms of partitioning graphs are a critical need.

This dissertation presents engineering models for two graph partitioning problems arising from completely …

Landslide Forecast In Taiwan Based On Machine Learning In The Gis Field, Yi Shen

Honors Capstones

Landslides can pose a significant risk to life, property, and infrastructure in mountainous regions, and can be triggered by various factors, including intense rainfall, earthquakes, and water level changes. Machine learning is commonly used to forecast landslides, based on statistical relationships between past landslides and multiple variables to create a general forecasting model. However, these models often require large amounts of data to achieve accurate results. This project aims to use only a few variables but take advantage of both their spatial distribution and temporal trends to improve the accuracy of landslide forecasts. This approach is tested in Taiwan, a …

Commencement Program: 2023, Governors State University

Commencement Documents and Videos

Ralph Anthony Sansone and Bhargavi Kasetti delivered the Student Addresses.

Myrna Montgomery performed "Lift Ev'ry Voice and Sing".

Lluvia Hernandez-Aguirre was recognized as the Student Trustee.

Sylvia Puente received the Honorary Doctor of Human Letters Degree.

At The End Of Life: Conceptualizing Human Dignity And Assisted Suicide Debates In Contemporary Germany, Edith-Marie Green

Honors Theses

As medicine improves and breakthroughs on cures for illnesses formerly thought deadly continue to develop, the global population continues to age. This has introduced new concerns about aging and end-of-life health care. One proposed end-of-life healthcare solution is assisted suicide, although the practice is not without its controversies. The case of assisted suicide in Germany is of particular interest for a variety of reasons, and the practice has not had an easy path there. A series of debates in 2015 led to the practice being banned, but that ban was overturned in 2020 by Germany’s Constitutional Court. While assisted suicide …

Differences In French Law Pertaining To Refugees From Former Colonies: A Case Study Of North Africa And Indochina, Lauren Bergin

Honors Theses

Colonial relations between colonizer and colonized are an interesting yet often understudied part of the legal field. This thesis will focus on these links within the relationship between France and two of its former colonies: North Africa and Indochina. In order to discover more information on these relationships, I take a historical approach focusing on legal documents, debates, and decrees, both from the French government and international bodies and representatives such as the United Nations High Commissioner for Refugees. The resulting discoveries show that French legal documents were far more concerned with North Africa compared to Indochina, both regarding asylum …

The “Afro In Afrolatinidad”: Examining Afrolatinx Experiences Of Blackness Through And Afrolatin Critical Theory Of Race, Celine Maria Ayala Ph.D

Sociology ETDs

Scholars of Afrolatinidad across disciplines often use their work to highlight the diversity of the Latinx community (Cahuas, 2019). Those who highlight Blackness in Latinidad tend to do so by merging Chicanx, and other Latinx theories with theories of Blackness that are centered on African American experiences. Although important, these works only tell one side of a multivariant story. Using a critical, diasporic, intersectional theoretical approach, which I call an Afrolatin Critical Theory of Race (ACTR), along with 30 semi-structured in-depth interviews, I find that Afrolatinx folk navigate Blackness, educational attainment and language in ways that debunk the myth of …

The Gayborhood Was Never Here For Some Of Us! Health Consequences Of Racialized Exclusion Among U.S. Sexual Minorities Across The Lifecourse, Kasim Ortiz

Sociology ETDs

Sexual minorities exhibit elevated rates of cigarette smoking, although disparate patterns exist when examining racial/ethnic differences among sexual minorities in the United States. Evidence suggests examining differing neighborhood contexts may help illuminate drivers of tobacco-related outcomes among sexual minorities, especially with respect to racial/ethnic variations among this understudied population. Adapting a framework of whiteness and health, the current project examined the role of racial residential segregation and neighborhood disadvantage as neighborhood contexts significantly associated with cigarette smoking across the adult lifespan. Using data from the 2010 Social Justice Sexual Project, merged with U.S. Census data, I find that residing in …

3d Printing Of Earthen Materials: Toward The Carbon-Zero Construction, Shiva Bhusal

Civil Engineering ETDs

In recent years, digital manufacturing techniques in the architecture and construction industry have rapidly gained attention, especially with 3D printing, also called additive manufacturing. The use of cement has been common in modern construction and is now being explored for 3D printing. However, due to cement's contribution to approximately 7 percent of global carbon emissions and its high cost, research on sustainable and greener materials has gained attention. Previous studies on alternative construction have examined the mechanical and rheological properties of soil mixes, but not much attention has been given to printability evaluation, shrinkage, and cracking, which can affect the …

Connecting Social And Ecological Systems In Small-Scale Fisheries In The Philippines, Sara Eisler Marriott

Dissertations

Nearly 50% of all marine fish capture in the Philippines is from artisanal fisheries, most of which is un- or under-reported. As in many emerging nations around the world, the Philippines cannot fully address overfishing by managing only half of the catch that comes from commercial fisheries. Marine reserves are a popular governance strategy for conservation and of growing interest for fisheries management. Many marine reserves in the Philippines, however, are not considered effective. In 2014, Rare, an international NGO, implemented a community-based management program to increase the effectiveness of the marine reserves, and while it found biomass increased, there …

Spring Commencement: May 13, 2023, University Of North Dakota

UND Commencement Programs

UND Spring Commencement program from May 13, 2023.

Understanding The Lived Experience Of The Embodiments Of Catholic Social Teaching By Doctoral Alumni From A School Of Education Of An Independent Catholic University: A Phenomenological Study, George Munjanattu

Graduate Theses, Dissertations, and Capstones

This study set out to understand how the doctoral alumni from the School of Education of an independent Catholic university experience embodiments of Catholic Social Teaching in their everyday lived experiences. The conceptual framework of seven Catholic teaching embodiments allowed the researcher to explore the perspectives of the doctoral alumni about their experiences with their values and beliefs about family, community, solidarity, human dignity, different responsibilities in their lives, care for creation, and their current engagement with various social justice activities. This research was a phenomenological qualitative study using interviews and artifacts review. Twelve participants were interviewed to explore their …

Determining The Utilization Of Trial-Based Functional Analyses In A Clinical Setting, Cayla Thomas

Thesis Projects

The functional analysis (FA) methodology is the gold standard of functional assessments to inform function-based interventions in applied behavior analysis. Behavior analysts report underuse of the FA methodology in clinical practice due to lack of time and resources and safety concerns. The trial-based FA (TBFA) is a brief form of the FA that is conducted in the natural environment and to date has mainly been conducted in classrooms. When compared with a standard FA, TBFAs take less consecutive time to complete, there are fewer instances of maladaptive behavior, data collection is simpler, and data analysis requires less expertise. The current …

Density And Nest Success Of Shrub-Dependent Birds On Formerly Strip-Mined Lands, Luke Headings

Electronic Theses & Dissertations

As bird populations continue to decline across North America, it is important to understand the benefits that disturbed habitats can have for breeding birds. One of the major land disturbances and causes of habitat loss in the United States is surface mining, which often results in altered vegetative communities. The primary goal of this study was to evaluate the relationships between bird populations, habitat, previous and current land use, and densities of invasive plant species on formerly strip-mined land. Due to the proliferation of invasive shrub species in post-mined landscapes, we sought to determine the effects of post-mined habitat features …