Digital Commons Network^™

All The Rumors Are True: Verification, Actual Malice, And Celebrity Gossip, Jasmine E. Mcnealy

Missouri Law Review

More than half of Americans get their news from social media. These spaces – social media platforms, video and audio recommender systems, social news and gossip boards – have their own fact-checking and editorial cultures that, although not the exact same as those found in newsrooms, offer similar controls for the distribution of information. While imperfect, just like the controls of traditional media, these fact-checking cultures may offer a response to recent US judicial rejection of actual malice and provide a route of inquiry for courts examining evidence to determine if a defamation plaintiff has met the heightened standard. This …

Half Past Inexcusable: The Lanham Act Needs To Disassociate With The Doctrine Of Laches, Jared Gillen

Missouri Law Review

Who condones time’s ability to place such an incessant stranglehold on one’s emotions? Well, no one, but it is inevitable: time dictates every facet of life. For example, a brief glance at the clock elicits a myriad of potential responses. One possibility is anticipation: painstakingly watching the clock count down the hours, minutes, and seconds until the weekend. The feeling is excruciating. However, the instant the minute hand aligns with that pesky 12 provides an instantaneous, captivating sense of relief. There is no feeling like 5 PM. Conversely, no amount of begging or pleading with Father Time can change the …

Form Over Substance: How Tort Reform Policy Prevailed Over Constitutional Protection, Kate Frerking

Missouri Law Review

Tort reform has become a prominent and contested issue as legislatures around the country are seeking to reconsider and rewrite the rules of civil tort litigation. Missouri, like many other states, focuses its effort on legislative remedy limitations in the form of statutory caps on noneconomic damages—attractive targets for nationwide reform efforts. There is uncertainty as to whether, and to what extent, this reform measure implicates the constitutional right to trial by jury. The Missouri Supreme Court addressed this issue in Ordinola v. University Physician Associates, and it affirmed the statutory caps on noneconomic damages imposed by the Missouri General …

Risky Routes: Modified Personal Vehicles, Public Safety, And Postal Services Under The Federal Tort Claims Act, Mary J. Smith

Missouri Law Review

Who says the holiday spirit ever goes out of season? It is beginning to look a lot like Christmas year-round on many doorsteps as packages from online retailers pile up, and postal carriers share an element of Santa’s stress: timely delivery. In 2021, the United States Postal Service (“USPS”) delivered roughly 128.9 billion pieces of mail across 233,171 mail routes. Demand for e-goods is at an all-time high, and the pressure to manage the demand might lead to a prioritization of success over safety. Unlike their urban counterparts, rural USPS offices are often unequipped to handle high volumes of delivery …

Dark Clouds Looming: The Uncertain Safety Of Welfare Benefits For Probationers And Parolees, Anthony M. Whalen

Missouri Law Review

How much is thirty dollars per month worth to the average American? For many, it is not much—it can be the cost of a streaming subscription or a ticket to a baseball game. For others, however, thirty dollars is the cost of freedom from incarceration. In January 2019, Randall Graves failed to meet the conditions of his probation, which required that he pay a monthly intervention fee of thirty dollars to the Department of Corrections instead of serving his six-year prison sentence. To some, thirty dollars may not be worth much, but to Graves, it was a metric of freedom.

Femtechnodystopia, Leah R. Fowler, Michael Ulrich

Faculty Scholarship

Reproductive rights, as we have long understood them, are dead. But at the same time history seems to be moving backward, technology moves relentlessly forward. Femtech products, a category of consumer technology addressing an array of “female” health needs, seem poised to fill gaps created by states and stakeholders eager to limit birth control and abortion access and increase pregnancy surveillance and fetal rights. Period and fertility tracking applications could supplement or replace other contraception. Early digital alerts to missed periods can improve the chances of obtaining a legal abortion in states with ever-shrinking windows of availability or prompt behavioral …

After Mccleskey, Robert L. Tsai

Faculty Scholarship

In the 1987 decision, McCleskey v. Kemp, the Supreme Court rejected a black death row inmate's argument that significant racial disparities in the administration of Georgia's capital punishment laws violated the Fourteenth Amendment's Equal Protection Clause. In brushing aside the most sophisticated empirical study of a state 's capital practices to date, that ruling seemingly slammed the door on structural inequality claims against the criminal justice system. Most accounts of the case end after noting the ruling's incompatibility with more robust theories of equality and meditating on the deep sense of demoralization felt by social justice advocates. One might …

Targeting Fatty Acid Reprogramming Suppresses Carm1-Expressing Ovarian Cancer, Simona Lombardi, Aaron R Goldman, Hsin-Yao Tang, Andrew V Kossenkov, Heng Liu, Meenhard Herlyn, Rugang Zhang

Faculty, Staff and Student Publications

The arginine methyltransferase CARM1 exhibits high expression levels in several human cancers, with the trend also observed in ovarian cancer. However, therapeutic approaches targeting tumors that overexpress CARM1 have not been explored. Cancer cells exploit metabolic reprogramming such as fatty acids for their survival. Here we report that CARM1 promotes monounsaturated fatty acid synthesis and fatty acid reprogramming represents a metabolic vulnerability for CARM1-expressing ovarian cancer. CARM1 promotes the expression of genes encoding rate-limiting enzymes of de novo fatty acid metabolism such as acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FASN). In addition, CARM1 upregulates stearoyl-CoA desaturase 1 (SCD1) …

Survival Outcomes Of Patients With Mycosis Fungoides Involving The External Ear And Ear Canal, Alex J Wilkinson, Marc-Elie Nader, Dianna Roberts, Madeleine Duvic, Jillian R Gunther, Paul W Gidley

Faculty, Staff and Student Publications

OBJECTIVES/HYPOTHESIS: Mycosis Fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. Disease involvement of specific locations may be more significant than simply the symptoms associated with that site; it is possible that involvement of certain sites could be associated with poor prognosis. We aimed to evaluate the outcomes of patients with MF with documented involvement of the EAC and external ear.

STUDY DESIGN: Retrospective analysis.

METHODS: We retrospectively reviewed 40 patients with MF that were treated by otologists between 2012 and 2021.

RESULTS: We report the largest series of patients with MF involving the external ear and EAC. …

Efficacy And Adverse Effects Of Ketamine Versus Electroconvulsive Therapy For Major Depressive Disorder: A Systematic Review And Meta-Analysis, Debora De A Simoes Moreira, Luís Eduardo Gauer, Guilherme Teixeira, Amanda Carolina Fonseca Da Silva, Stefanie Cavalcanti

Faculty, Staff and Student Publications

Background: ECT is considered the fastest and most effective treatment for TRD. Ketamine seems to be an attractive alternative due to its rapid-onset antidepressant effects and impact on suicidal thoughts. This study aimed to compare efficacy and tolerability of ECT and ketamine for different depression outcomes (PROSPERO/CRD42022349220).

Methods: We searched MEDLINE, Web of Science, Embase, PsycINFO, Google Scholar, Cochrane Library and trial registries, which were the ClinicalTrials.gov and the World Health Organization's International Clinical Trials Registry Platform, without restrictions on publication date.

Selection criteria: randomized controlled trials or cohorts comparing ketamine versus ECT in patients with TRD.

Results: Eight studies …

Concomitant Targeting Of Flt3 And Btk Overcomes Flt3 Inhibitor Resistance In Acute Myeloid Leukemia Through The Inhibition Of Autophagy, Weiguo Zhang, Guopan Yu, Hongying Zhang, Mahesh Basyal, Charlie Ly, Vivian Ruvolo, Seemana Bhattacharya, Qi Zhang, Gautam Borthakur, Venkata Battula, Marina Konopleva, William G Rice, Michael Andreeff

Faculty, Staff and Student Publications

Strategies to overcome resistance to FMS-like tyrosine kinase 3 (FLT3)-targeted therapy in acute myeloid leukemia (AML) are urgently needed. We identified autophagy as one of the resistance mechanisms, induced by hypoxia and the bone marrow microenvironment via activation of Bruton tyrosine kinase (BTK). Suppressing autophagy/BTK sensitized FLT3- mutated AML to FLT3 inhibitor-induced apoptosis. Furthermore, co-targeting FLT3/BTK/aurora kinases with a novel multikinase inhibitor CG-806 (luxeptinib) induced profound apoptosis in FLT3-mutated AML by co-suppressing FLT3/BTK, antagonizing autophagy, and causing leukemia cell death in FLT3-wildtype AML by aurora kinase-mediated G2/M arrest and polyploidy, in addition to FLT3 inhibition. Thus, CG-806 exerted profound anti-leukemia …

A Role For Protein Arginine Methyltransferase 7 In Repetitive And Mild Traumatic Brain Injury, Christina H Acosta, Garrett A Clemons, Cristiane T Citadin, William C Carr, Mariana Sayuri Berto Udo, Henry W Sanicola, Jamie B Toms, J Dedrick Jordan, Bharat Guthikonda, Celeste Yin-Chieh Wu, Reggie Hui-Chao Lee, Hung Wen Lin

Faculty, Staff and Student Publications

Mild traumatic brain injury affects the largest proportion of individuals in the United States and world-wide. Pre-clinical studies of repetitive and mild traumatic brain injury (rmTBI) have been limited in their ability to recapitulate human pathology (i.e. diffuse rotational injury). We used the closed-head impact model of engineered rotation acceleration (CHIMERA) to simulate rotational injury observed in patients and to study the pathological outcomes post-rmTBI using C57BL/6J mice. Enhanced cytokine production was observed in both the cortex and hippocampus to suggest neuroinflammation. Furthermore, microglia were assessed via enhanced iba1 protein levels and morphological changes using immunofluorescence. In addition, LC/MS analyses …

Trpv4 Expression In The Renal Tubule Is Necessary For Maintaining Whole Body K+ Homeostasis, Anna Stavniichuk, Kyrylo Pyrshev, Oleg Zaika, Viktor N Tomilin, Mariya Kordysh, David Križaj

Faculty, Staff and Student Publications

The Ca2+-permeable transient receptor potential vanilloid type 4 (TRPV4) channel serves as the sensor of tubular flow, thus being well suited to govern mechanosensitive K+ transport in the distal renal tubule. Here, we directly tested whether the TRPV4 function is significant in affecting K+ balance. We used balance metabolic cage experiments and systemic measurements with different K+ feeding regimens [high (5% K+), regular (0.9% K+), and low (<0.01% K+)] in newly created transgenic mice with selective TRPV4 deletion in the renal tubule (TRPV4fl/fl-Pax8Cre) and their littermate controls (TRPV4fl/fl). Deletion was verified by the absence of TRPV4 protein expression and lack of TRPV4-dependent Ca2+ influx. There were no differences in plasma electrolytes, urinary volume, and K+ levels at baseline. In contrast, plasma K+ levels were significantly elevated in TRPV4fl/fl-Pax8Cre mice on high K+ intake. K+-loaded knockout mice exhibited lower urinary K+ levels than TRPV4fl/fl mice, which was accompanied by higher aldosterone levels by day 7. Moreover, TRPV4fl/fl-Pax8Cre mice had more efficient renal K+ conservation and higher plasma K+ levels in the state of dietary K+ deficiency. H+-K+-ATPase levels were significantly increased in TRPV4fl/fl-Pax8Cre mice …

Dusp22 Rearrangement Is Associated With A Distinctive Immunophenotype But Not Outcome In Patients With Systemic Alk-Negative Anaplastic Large Cell Lymphoma, Lianqun Qiu, Guilin Tang, Shaoying Li, Francisco Vega, Pei Lin, Wei Wang, Luis Malpica, Roberto N Miranda, Sergej Konoplev, Zhenya Tang, Hong Fang, L Jeffrey Medeiros, Jie Xu

Faculty, Staff and Student Publications

DUSP22 rearrangement (R) has been associated with a favorable outcome in systemic ALK-negative anaplastic large cell lymphoma (ALCL). However, a recent study found that patients with DUSP22-R ALK-negative ALCL have a poorer prognosis than was reported initially. In this study, we compared the clinicopathological features and outcomes of patients with ALKnegative ALCL with DUSP22-R (n=22) versus those without DUSP22-R (DUSP22-NR; n=59). Patients with DUSP22-R ALCL were younger than those with DUSP22-NR neoplasms (P=0.049). DUSP22-R ALK-negative ALCL cases were more often positive for CD15, CD8, and less frequently expressed pSTAT3Tyr705, PD-L1, granzyme B and EMA (all P0.05), but was significantly shorter …

Antioxidant Activity And Total Phenolic Compounds Of Commiphora Gileadensis Extracts Obtained By Ultrasonic-Assisted Extraction, With Monitoring Antiaging And Cytotoxicity Activities, Hani Ahmed, Marwan M A Rashed, Marwan Almoiliqy, Mohammed Abdalla, Mohanad Bashari, Zhu Hailin, Ahmed Eibaid, Jinpeng Wang, Li-Ping Jiang

Faculty, Staff and Student Publications

Commiphora gileadensis (C. gileadensis) has been identified and linked with various health benefits and pharmaceutical potential for its phytochemical activities and chemical constituents. This study aimed to evaluate ultrasonic‐assisted extraction (USE) technique for total phenols content from C. gileadensis leaf compared to the hydrodistillation extraction (HDE). Our results showed that the USE operating conditions were identified as: MeOH·H2O solvent‐to‐fresh sample ratio of 80:20 (v/v); ultrasonic power/frequency at 150 W/20 kHz; and a temperature of 40 ± 1°C; subjected to acoustic waves intermittently for a calculated time (5 min) during the total programmed time of 12 min. The USE …

Metabolic Adaptation To Consume Butyrate Under Prolonged Resource Exhaustion, Sophia Katz, Claudia Grajeda-Iglesias, Bella Agranovich, Alia Ghrayeb, Ifat Abramovich, Eyal Gottlieb

Faculty, Staff and Student Publications

Bacteria must often survive following the exhaustion of their external growth resources. Fitting with this need, many bacterial species that cannot sporulate, can enter a state known as long term stationary phase (LTSP) in which they can persist for years within spent media. Several recent studies have revealed the dynamics of genetic adaptation of Escherichia coli under LTSP. Yet, the metabolic consequences of such genetic adaptation were not addressed. Here, we characterized the metabolic changes LTSP populations experience, over the first 32 days under LTSP. This allowed us to link genetic adaptations observed in a convergent manner across LTSP populations …

5s Rrna Pseudogene Transcripts Are Associated With Interferon Production And Inflammatory Responses In Alcohol-Associated Hepatitis, Jianguo Wu, Adam Kim, Xiaoqin Wu, Semanti Ray, Daniela S Allende, Annette Bellar, Srinivasan Dasarathy, Laura E Nagy

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: Interferon (IFN) signaling is critical to the pathogenesis of alcohol-associated hepatitis (AH), yet the mechanisms for activation of this system are elusive. We hypothesize that host-derived 5S rRNA pseudogene (RNA5SP) transcripts regulate IFN production and modify immunity in AH.

APPROACH AND RESULTS: Mining of transcriptomic datasets revealed that in patients with severe alcohol-associated hepatitis (sAH), hepatic expression of genes regulated by IFNs was perturbed and gene sets involved in IFN production were enriched. RNA5SP transcripts were also increased and correlated with expression of type I IFNs. Interestingly, inflammatory mediators upregulated in sAH, but not in other liver …

Belief And Success Health Management Self-Efficacy: A National Survey Of Black Adults, Stephanie Y. Store

Dissertations, Theses, and Capstone Projects

Minority populations, such as Black adults of non-Latinx descent, are more likely to develop chronic diseases and complications related to disease severity when compared to Non-Latinx Whites (NLW). Furthermore, Black adults of non-Latinx descent people are less likely to engage and maintain health promoting behaviors (HPB) to prevent disease development. HPB are effective in preventing or delaying chronic disease. This research explores the relative impact of aspects of health, built environment and key demographic domains on HMSE of a national sample of Black adults. Methods: Hierarchical regression modeling was performed utilizing data from the 2018 National Survey of Health Attitudes …

Beyond The Songs On The Vistula: Chopin And Poland, A Mythical Construction, Juan Carlos Fernandez-Nieto

Dissertations, Theses, and Capstone Projects

Poland and Chopin are two concepts that cannot be separated, for they form an entity of their own. However, the story of both subjects has often been manufactured to offer a view of the patriotism and the connection of Chopin with his country, which promoted the creation of the nation. At the same time, the circumstances that propitiated the rise of nationalism and the social unrest that ended with World War I were the same that promoted the myth of Chopin. Therefore, this research is focused on the analysis of the facts and the context that created the myth of …

Propensity Score Analysis And Machine Learning: A Comparison And Application To Post-Secondary Education Data, Khudodod Khudododov

Dissertations, Theses, and Capstone Projects

Estimation methods to identify the causal relationships between dependent and independent variables are fundamental to social science research. For social workers, these methods provide crucial knowledge about different factors' complex relationships with a particular issue. Such knowledge helps social workers be better micro, mezzo, and macro change agents.

Different causal estimation methods exist, from randomized controlled studies to methods involving observational studies. In observational studies, which is the focus of this dissertation, participants self-select into intervention. This behavior makes causal estimation more challenging. Since participants self-select into intervention or treatment, there are observed and unobserved differences between participants in the …

Gaps Of Speculation: Refusing Representation In Queer And Postcolonial Fiction, Sarah Schwartz

Dissertations, Theses, and Capstone Projects

This dissertation examines how queer and postcolonial novels respond to the archive as a determiner of what stories we can and cannot tell through formal experimentation that omits expected elements. Focusing on the subject- and object-making power and the tekhne of inclusion and exclusion that shape the modern archive, I analyze how novels spanning the late nineteenth century to the early twenty-first century refuse to mimetically reproduce bodies that were traditionally made the object of that knowledge in ways legible to the familiar archival forms. Instead, these novels turn the exclusion of the archive back on itself by manifesting lacunae …

Evolutions In Suicide Bombing: Exploring The Relationship Between The Tactic And Its Application By Non-State Armed Groups Across Various Conflict Zones Over Time, David E. Firester

Dissertations, Theses, and Capstone Projects

The following dissertation considers variations in the use of suicide bombing by Non-State Armed Groups (NSAGs), at the organizational level of analysis. It is both a quantitative and qualitative assessment of the conditions under which insurgents that accept the practice’s legitimacy have applied it to a range of specified target sets. The broad focus of this endeavor centers on unpacking insurgent groups’ behaviors across a number of unique battlespaces, but the main question I seek to answer is: what decision dynamics accompany violent non-state actors’ use of suicide bombing and how do we interpret their behavioral interaction across various conflict …

Mood: A Zine Exploring The Value Of Youth-Oriented Media, Patricia K. Paul

Dissertations, Theses, and Capstone Projects

Media is a constant, persistent force in human lives that informs and influences through published, broadcasted, and digitally mediated formats. Mass media industries produce and distribute content consumed by diverse audiences, though the facilitators represent only a fraction of the demographics they serve.

Youth denote one of the most frequently misrepresented groups, with very few practical opportunities for young people to make decisions about the texts available to them. A jarring absence of youth participation in media creation at all levels suggests cultural contributions through art exclude young people's authentic perspectives and desires. Moreover, media portrayals of youth cannot adequately …

The Impact Of Semantics And Syntax On Lexical Retrieval In Individuals With Aphasia, Marta M. Korytkowska

Dissertations, Theses, and Capstone Projects

Nearly all people with aphasia (PWA) report difficulty with lexical retrieval (i.e., anomia). While there are several tasks used to measure lexical retrieval, each poses different degrees and types of challenges. For example, some studies have found that PWA performance varies depending on the type of lexical retrieval task. The tasks that have been used include lexical retrieval in isolation tasks (such as picture-naming), lexical retrieval in sentence level tasks (such as narration tasks), and lexical retrieval in sentence-completion tasks. Some studies have found no differences between the accuracy of lexical retrieval in isolation and at the sentence level (e.g., …

A Gift To My Self: A Psychoanalytic Approach To Understanding The Experiences Of Women Who Choose Not To Have Children, Irina D. Tchania

Dissertations, Theses, and Capstone Projects

Although motherhood has long been a normative female experience, individual decisions regarding bearing and mothering children vary among women. Partly due to shifts in gender roles and contemporary societal expectations, the conflation of womanhood with motherhood – and the centrality of motherhood within female identity – is being increasingly challenged. Women who choose to remain childless make up a growing, unique, and understudied population group. Decisions regarding intentional childlessness have been considered through the lenses of sociology and feminist critique, while psychologically and psychoanalytically oriented scholarship is more limited. This study aimed to further our understanding of the voluntarily childless …

Emancipatory And Retributive Labor: Conflicting Representations Of Enslaved Labor In Us And Caribbean Literature, 1830–1855, Michael Druffel

Dissertations, Theses, and Capstone Projects

Emancipatory and Retributive Labor follows the development of a concept that I call emancipatory labor as it appeared in the US and Caribbean during the period 1830 to 1855. Emancipatory labor is a subversive tactic in which enslaved people in the United States and Caribbean redefined a portion of their labor in capitalist terms. Re-theorizing a portion of enslaved labor stakes a claim to agency and humanity according to Western, humanistic logic. Examples of the types of labor being redefined include selling commodities, hiring time, and working “extras” for wages. I use enslaved person Lunsford Lane’s 1842 narrative as a …

Jus Soli And Jus Sanguinis: Politics, Race, Culture, And Citizenship In The Dominican Republic And Haiti, Guido A. Proano

Dissertations, Theses, and Capstone Projects

The promulgation of laws such as the Dominican Republic’s Constitutional Court’s Judgment TC-168-13 serves as a basis upon which to argue the major impediments presented by the Dominican government to deny Haitians and Dominicans of Haitians descent citizenship. The right to citizenship is based on legal principles of jus soli and jus sanguinis and is recognized in a series of international legal documents. Following a Marxist framework, this research demonstrates the uncounted possible relationships between modern social forces and politics that have been working closely following European productions of knowledge for decades against Haitians and Dominicans of Haitian descent in …

Numbered, Weighed, Divided: Revolution And/As Apocalypse In The Modern Liberal Tradition, Asher J. Wycoff

Dissertations, Theses, and Capstone Projects

A long-standing political-theological critique contends that liberalism lacks the capacity to address theological challenges, and qualitative political challenges more generally. This charge is prevalent in our current age of crises, when the capacity to address such challenges is essential to any political tradition’s self-legitimation. I argue that the liberal tradition, broadly conceived, has long contended with theological challenges, particularly during modern revolutionary periods. Theological discourses, especially eschatological ones, circulate widely in these moments. Modern political actors impute cosmic significance to the events of their present, with a central analogy crystallizing between revolution and apocalypse. Reading major theorists of three modern …

Babel, Daniel Horowitz

Dissertations, Theses, and Capstone Projects

This thesis is a series of three memoiristic essays around the vortex of identity. The first is an exploration of how childhood overmedication split the continuity of the author’s self-conception. The second traces the slipperiness of Jewish and Queer identifications detailing their synthesis in the klezmer revival in New York City in late 1980s and early 90s. The third is a polyphonic narration of the recovery of a lost klezmer’s life story in the face of the silence of time and slaughter.

Examining The Role Of Evidence-Based Suspicion In Racial Disparities In Wrongful Convictions, Jacqueline Katzman

Dissertations, Theses, and Capstone Projects

There are clear racial disparities in the rates of wrongful convictions, with Black exonerees disproportionately represented among the population of those exonerated, in DNA and non-DNA exonerations alike (National Registry of Exonerations, 2022; Innocence Project, 2022). This racial disparity also exists for those exonerees who were wrongfully convicted, at least in part, because an eyewitness mistakenly identified them. For decades, when eyewitness scholars explored racial bias, they focused on the cross-race effect or own-race bias among eyewitnesses, a bias positing that witness performance suffers when a witness is asked to make an identification of a cross-race face (Lee & Penrod, …