Digital Commons Network^™

Beth Boyd V. Shriners Hospitals For Children

2026 Decisions

USDC for the Western District of Pennsylvania

Quantitative Proteomics For The Investigation Of Phosphoprotein Phosphatase 1 And 3 Substrate Specificities, Galini Poimenidou

Dartmouth College Ph.D Dissertations

Reversible phosphorylation is a crucial post-translational modification (PTM) that modulates a variety of signaling pathways intracellularly, with aberrant protein phosphorylation being a hallmark of many human diseases. Kinases, which catalyze phosphorylation of their substrates, have been extensively studied in the context of the signaling pathways they regulate and their effects on cellular processes. In contrast, phosphoprotein phosphatases (PPPs), which catalyze the removal of phosphate groups from substrate proteins, have only recently come to the research spotlight. For a long time, protein phosphatases were deemed unspecific housekeeping enzymes, but they are now known to display exquisite substrate specificity. Phosphoprotein phosphatase 1 …

Engineering Ferrate(Vi) For Water And Wastewater Treatment: Translating Science Into Technology, Zepei Tang, Zhenli He, Yang Deng

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Over the past five decades, ferrate(VI) (FeO42–) for water and wastewater treatment has remained largely at the laboratory scale, with limited pilot- and full-scale implementation. This gap between sustained research and scarce real-world deployment places the technology in the Valley of Death─a high-risk stage of development─and highlights the need for an engineering-centric approach to enable practical application. This article presents an engineering framework to guide the development and translation of ferrate(VI) technology for water and wastewater treatment. From a system perspective, ferrate(VI) technology comprises three core subsystems: generation, treatment, and solid–liquid separation. Technology maturity depends on both the advancement of …

The "Quiet Professionals": Oral Histories Of The United States Special Forces Veterans Of The Global War On Terror, Chase Rumbley

Electronic Theses and Dissertations

This thesis examines how United States Army Special Forces veterans of the Global War on Terror narrate the identity of the "Quiet Professional" across training, deployment, and post-service life. Drawing on oral history interviews with four retired Green Berets, as well as archival and material culture analysis, the study approaches Special Forces as a distinctive military institution shaped by narrative, institutional formation, and war. It argues that Special Forces ethos is not a fixed warrior identity, but a lived and contested achievement produced through rites of passage, embodied hardship, informal legitimacy, and collective memory. Participants describe becoming Special Forces as …

Artificial Intelligence-Assisted Neuropharmacology: Reshaping Drug Discovery And Translational Strategies For Neurological Diseases ​, Pri̇yanka Rathee, Suni̇thi̇ Lohan, Sari̇ta Khatkar, Neelam Mali̇k, Esra Akkol, Renu Sehrawat, Pooja Rathee, Anurag Khatkar

Turkish Journal of Medical Sciences

The rapid expansion of data-driven technologies, particularly machine learning (ML) and artificial intelligence (AI), has substantially influenced biomedical research and drug discovery. In neuropharmacology, the availability of large-scale genomic, proteomic, chemical, and clinical datasets has stimulated the adoption of AI-based approaches to address persistent challenges in neurological drug development, including high attrition rates and the scarcity of disease-modifying therapies. Unlike prior reviews that broadly discuss AI applications in drug discovery or neurology, this narrative review focuses specifically on neuropharmacology, with an emphasis on translational relevance, disease-oriented examples, and real-world constraints. We critically examine the application of AI and ML across …

Asthma Data In Türkiye Between 2016 And 2022: A Nationwide Descriptive And Observational Study Covering The Entire Adult Population, Kurtuluş Aksu, Gürgün Tuğçe Vural Solak, Nai̇m Ata, Mustafa Hami̇dullah Türkkani, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Funda Aksu

Turkish Journal of Medical Sciences

Background/aim: Determining the current burden of asthma in countries is important in the diagnosis and follow-up of asthma patients and for the development of national health policies. Our study aimed to clarify the epidemiological and clinical data regarding asthmatic adults in Türkiye.

Materials and methods: The study was designed as a nationwide descriptive, observational cross-sectional study. Data on adult patients who were followed with the diagnosis of asthma in all public, private, and university hospitals in Türkiye between January 2016 and December 2022 were obtained from the e-Nabız database of the Ministry of Health and analyzed.

Results: The number of …

Johnson & Johnson V. Samsung Bioepis Co Ltd

2026 Decisions

USDC for the District of New Jersey

Front Matter

Texas A&M Law Review

Front Matter.

The Deregulation Of Cancer, Daniel G. Aaron

Texas A&M Law Review

Fifty years ago, the U.S. embarked on a radical new path. Under pressure from the environmental movement, Congress passed an array of statutes aimed at regulating carcinogens out of our world. This regulatory experiment sprawled from air and water to food and consumer products.

Legal scholars have paid scant attention to this wave of cancer regulation despite its size and importance and the public’s apparent interest in avoiding carcinogens. But there is a growing literature finding flaws with individual regimes within the framework, such as the Clean Air Act, the Toxic Substances Control Act, and the Tobacco Control Act. In …

Individualized Cannabis Reparations, Scott Bloomberg

Texas A&M Law Review

This Article makes an argument that should be obvious. The best way for governments to right the wrongs of cannabis prohibition is to give money to people with cannabis offenses. Nonetheless, this straightforward reform has been consistently overlooked, dismissed, or minimized by policymakers and scholars alike, eschewed in favor of other social equity programs that do not right those wrongs nearly as effectively. Governments have indeed invested hundreds of millions of cannabis tax dollars in social equity licensing programs and community reinvestment initiatives. These programs—while often worthwhile—do not benefit the vast majority of people with past cannabis offenses.

Governments should …

Hester's Dubious Roots And Legacy: Open Fields Doctrine Under Scrutiny, Laura K. Donohue

Texas A&M Law Review

For over a century, open fields doctrine has shaped Fourth Amendment law, denying people the right to be secure on their own property. Its impact has steadily expanded, with the result that, by some estimates, the government can now engage in warrantless surveillance of some 96% of private land and buildings regardless of fences, postings, the distance from public roads or byways, or the use to which the property is put. An originalist approach throws the doctrine into disarray: at the time of the Founding, common law protected the curtilage, which extended to the fields, barns, storehouses, and other buildings …

The Unexplored Future Of State Copyrights And Patents In Ai-Generated Creations, Timothy J. Mcfarlin

Texas A&M Law Review

This is the first article to broadly explore the possibility of state copyrights and patents in AI-generated creations and what it could portend for the future of intellectual property law.

The U.S. Constitution delegates to Congress, via Article I, the power to pass laws “securing for limited times to authors and inventors the exclusive right to their respective writings and discoveries.” It reserves to the states or to the people, via the Tenth Amendment, certain unspecified powers not delegated to the federal government. These could include the power to recognize exclusive rights in “writings and discoveries” generated by artificially intelligent …

"The Silence Of The Farms": Suppressing Speech And Trampling Transparency To Shield Big Ag, Erin Okuno

Texas A&M Law Review

Do you really know where your last meal came from and whether it was safe to eat? Most people are not aware of the often appalling conditions at agricultural production facilities (aptly known as “factory farms”), including worker injuries and abuse, contaminated food, and environmental pollution, as well as the horrific ways in which the animals are kept, raised, and slaughtered. In the face of these concerning conditions and alarmingly frequent food recalls—including millions of pounds of contaminated meat—it would seem prudent to increase transparency at factory farms, but historically, they have operated behind a shield of secrecy due to …

Regulating Data Monetization, Peter Ormerod

Texas A&M Law Review

Companies today generate hundreds of billions of dollars each year by collecting massive amounts of information about human activity and wringing predictive insights from it. The scale of these influence activities is stunning: your driving habits dictate your car insurance rates, buying the wrong thing will increase your borrowing costs, and the information ecosystem you inhabit is finely tuned for keeping your attention available to the highest bidder.

States have recently enacted new consumer privacy laws that confer on individuals a series of generally applicable rights over their personal information. But this approach has proven ineffective at disciplining firms’ data …

Resolving Bankruptcy's Non-Voting Impaired Class Issue Using The Nonfactor Solution, Jacob Harrington

Texas A&M Law Review

In chapter 11 bankruptcy voting procedures, the issue of non-voting impaired classes can be a complicated issue, but the Southern District of Texas’s new “nonfactor” approach can be used as a lens through which different solutions to this issue may be understood. The United States Bankruptcy Code states that a bankruptcy plan may only be confirmed if every impaired class votes to accept the plan. But despite the statute’s apparent clarity, different jurisdictions’ solutions vary, some deeming non-voting impaired classes to plan. This Note demystifies the Bankruptcy Code’s approach to this matter, examines the different jurisdictional approaches to this issue, …

Adjudicating 35 U.S.C. § 112(A): The "Person Of Ordinary Skill In The Art" Conundrum And How To Address It, Matthew T. Simmons

Texas A&M Law Review

A viable alternative for adjudicating issues under 35 U.S.C. § 112(a) of the Patent Act is needed due to the difficulties of trying these issues to a lay jury. Congress agreed when it enacted the America Invents Act (“AIA”), which created alternative proceedings for challenging patent validity post-grant, including post-grant review (“PGR”) and inter partes review (“IPR”). In theory, PGR proceedings permit the Patent Trial and Appeal Board of the United States Patent and Trademark Office to adjudicate whether one or more claims of a patent are valid on § 112 grounds. In practice, history has shown that the limitations …

Empowering E-Commerce Using Fog Computing To Distributed Nodes Management With Data Centers, Wael Hadeed, Nagham Sultan, Mohammed Yousif

Mesopotamian Journal of Big Data

Cloud computing has always been an essential part of big data analytics, providing several significant benefits such as pooled resources, availability on-demand, and quick scalability. Nevertheless, handling data-intensive workflows in such highly changing environments is still a problem. Excessively allocating resources may unnecessarily increase the operating cost, while insufficiently allocating resources may cause Service Level Agreement (SLA) violations and drop in the Quality of Service (QoS). This document explores the issues around data center deployment in the fast-changing e-commerce industry where continuous technological increments are vital to satisfying ever-changing customer needs. The main aim is to manufacture a sophisticated resource …

The Fate Of Atkins In A Post-Dobbs Era: How State Discretion Risks Harm To Intellectually Disabled And Black Defendants, Chole Quinn Sotomayor

Cardozo Journal of Equal Rights and Social Justice (ERSJ) Blog

The Supreme Court’s stance on the death penalty has evolved over time. In Furman v. Georgia, the Court held that the death penalty violated the Eighth Amendment, only to reinstate it in Gregg v. Georgia four years later.  As the Court continued to interpret “evolving standards of decency,” it later categorically barred the execution of defendants with an intellectual disability in Atkins v. Virginia.  To determine if an individual is intellectually disabled, they must demonstrate subaverage adaptive skills that existed before age eighteen.  The Court has also recognized that IQ scores carry a ±5 margin of error and has …

Inequality And Well-Being, Sarah E. Boslaugh

Theses

Human well-being has been a topic of interest to philosophers at least since the time of Aristotle, and well-being has also been a core concern of social scientists since the birth of the discipline in the late 18^th century. Some theories of well-being include economic inequality as a factor, and multiple ways to measure this factor have been developed; as with well-being, there is no single best measure of economic inequality and the choice of which measure to use may be based on both theoretical and practical reasons. I argue that income inequality should always be included as a …

Artificial Intelligence In Low-Dose Computed Tomography Lung Cancer Screening: Clinical Integration, Validation, And Translational Challenges, Valeria Vanessa Varela Betancourt, Archana Acharya, Nusrat Jahan, Udit Kapahi, Insharah Khalid, Syed Maaz Shah, Hassan Ibrahim, Bushra Nawaz, Shazma Shayan, Maia Valls Palacios Reese, Sheeza Nadeem, Manju Rai

Student Publications

Lung cancer remains the leading cause of cancer-related mortality worldwide, largely due to late-stage diagnosis. Low-dose computed tomography (LDCT) screening has demonstrated significant mortality reduction in high-risk populations; however, its widespread implementation is limited by high false-positive rates, inter-reader variability, and substantial workflow burden. Artificial intelligence (AI) has emerged as a promising adjunct to address these challenges by enhancing diagnostic consistency, efficiency, and risk stratification in LDCT-based screening. This narrative review aims to synthesize current evidence on AI methodologies, clinical applications, validation studies, and translational challenges in LDCT-based lung cancer screening. A structured literature search was conducted across PubMed, Scopus, …

Usa V. Brock Cochran

2026 Decisions

USDC for the Western District of Pennsylvania

Dapk2 Regulates Pkm2 Phosphorylation At Threonine 45 To Facilitate Disturbed Flow-Induced Atherosclerosis, Shuai Guo, Long Xu, Yixin Chen, Yuan Zhao, Yuting Zhang, Runfa Yu, Kaixiang Cao, Litao Wang, Wenjia Ai, Jiang-Yun Luo, Lu Lu, Jun He, Yuan Zhou, Li Wang, Andrew H Baker, Yuqing Huo, Yiming Xu

Faculty, Staff and Students Publications

Background: Oscillatory shear stress (OSS), resulting from disturbed blood flow, is implicated in atherosclerotic plaque formation by incompletely understood mechanisms. This study aims to elucidate the involvement of death-associated protein kinase (DAPK) 2 in OSS-induced endothelial cell (EC) activation and atherosclerosis.

Methods: Publicly available resources, including genome-wide microarray, RNA sequencing, and single-cell RNA sequencing, were utilized to identify key OSS-sensitive regulatory factors. Techniques such as mass spectrometry, immunoprecipitation, proximity ligation assay, and RNA sequencing were employed to identify pyruvate kinase M2 (PKM2) as the binding protein of DAPK2 and determine the specific site of PKM2 phosphorylation by DAPK2. To assess …

Retinal Microvascular And Neuroretinal Structural Changes In Pulmonary Arterial Hypertension Assessed By Octa: A Comparative Study ​, Murat Erdağ, Tunahan Çalişkan, Hakan Yildirim, Tarik Kivrak, Mehmet Canleblebi̇ci̇, Ali̇ Dal, Mehmet Balbaba

Turkish Journal of Medical Sciences

Background/aim: Pulmonary arterial hypertension (PAH) is a progressive disorder with systemic vasculopathy, and noninvasive assessment remains challenging. The retina, sharing anatomical similarities with the cerebral microcirculation, is an accessible site for visualizing systemic vascular compromise. This study quantitatively evaluated retinal microvascular and neuroretinal structural changes in PAH patients compared to healthy controls using optical coherence tomography angiography (OCTA).

Materials and methods: In this single-center, cross-sectional case-control study, 40 patients with group 1 PAH and 38 healthy controls were enrolled. For statistical independence, only the right eye of each participant was analyzed (total: 78 eyes). All participants underwent high-resolution OCTA imaging. …

Post-Exposure Prophylaxis For Hiv Among Healthcare Workers In Türkiye: A Descriptive, Multicenter Retrospective Study, Veysel Akca, İlkay Akbulut, Gül Ruhsar Yilmaz, Alper Tahmaz, Nefi̇se Öztoprak Çuvalci, İlknur Esen Yildiz, Mehmet Çabalak, Şeyma Topal, Özgür Günal, Bi̇rcan Kayaaslan, Fatma Eser, Tuba Damar Çakirca, Deni̇z Ölmez, Ali̇ye Baştuğ, Fi̇rdevs Aksoy, Hani̇fe Nur Karakoç Parlayan, Beyza Süllü, Damla Verendağ, Hatun Öztürk Çeri̇k, Mehmet Ali̇ Aşan, Ayhan Akbulut, Gülden Eser Karlidağ, Behi̇ce Kurtaran, Hüsnü Pullukçu, Turhan Togan

Turkish Journal of Medical Sciences

Background/aim: Post-exposure prophylaxis (PEP) for human immunodeficiency virus (HIV) plays a vital role in preventing transmission among healthcare workers following occupational exposure. Despite its clinical importance, epidemiological data regarding PEP implementation in Türkiye remain scarce. This study aimed to assess PEP practices, prophylactic treatment regimens, and follow-up outcomes among healthcare workers at risk of occupational HIV exposure.

Materials and methods: This retrospective, multicenter study was conducted between January 2020 and December 2024 across 16 healthcare facilities participating in the National HIV/AIDS Working Group. Healthcare workers aged 18 years and older who presented for evaluation following occupational exposure to HIV were …

Academic Senate - Agenda, 04/14/2026, Academic Senate

Academic Senate Agendas

No abstract provided.

As-1006-26 Resolution On Changes In Academic Senate Grants Review Committee Membership, Grants Review Committee

Academic Senate Resolutions

Resolves that the attached modification to the Grants Review Committee be adopted beginning fall 2026.

Hypertext Transfer Protocol Fingerprinting: Techniques For Attacker-In-The-Middle Proxy Detection, Evasion, And Counter-Evasion, Jensen George Wood

Theses and Dissertations

Attacker-in-the-middle (AitM) phishing toolkits have emerged as a critical threat to enterprise and individual security by enabling adversaries to bypass multi-factor authentication (MFA) and compromise cloud-based accounts at scale. Traditional detection techniques--such as IP blocklists or content-based detection methods--are often ineffective against these increasingly sophisticated attacks. We propose a novel method that detects malicious proxies by identifying artifacts they introduce into HTTP request headers. To evaluate our approach, we systematically analyze traffic passed through several open-source AitM toolkits and proxies, identifying distinct modifications to header structures and content, then formalize these features as YARA rules for automated use. To validate …

The Justice Department’S Bid To Avoid Accountability, Bruce A. Green, Rebecca Roiphe

Other Publications

No abstract provided.

Jeremy Miller V. Monsanto Co

2026 Decisions

USDC for the District of Delaware

Mastery By Mistakes: Reframing Failure In Higher Education Skill-Based Teaching And Assessment, Maura Metheny

JWU Dissertations & Theses

Experiencing a mistake, error or failure while learning generates an additional inquiry process that activates prior knowledge and increases retention of subsequent feedback and new material (Kapur, 2008). The use of errors to guide practice has been shown to lead to skill-mastery and expertise (Ericsson et al., 1993). When classrooms are psychologically safe environments where penalty-free exploration and knowledge application are encouraged, students gain a deeper understanding of the content (Tulis, 2013). This qualitative exploratory descriptive study aimed to understand the ways that undergraduate faculty in skill-based disciplines involve errors, mistakes and failures in teaching and …