Regional Variation Of Underlying Kidney Diseases In Children Undergoing Chronic Kidney Replacement Therapy Around The Globe., Dagmara Borzych-Dużałka, Marjolein Bonthuis, Uma Ali, Yok-Chin Yap, Michael Manno, Yihui Zhai, Reyner Loza, Seema Hashmi, Naye Choi, Kenza Soulami, Judith Exantus, Mohamed S. Al Riyami, Sameh Mabrouk, Marbella Ma Angeles, Cristina Zelaya-Camacho, Henny Adriani Puspitasari, Syed Saimul Huque, Francisco Cano, Kar Hui Ng, Sevcan A. Bakkaloğlu, Jerome Harambat, Kitty J. Jager, Bradley A. Warady, Franz Schaefer

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: There is a scarcity of information regarding the distribution of the diseases leading to kidney failure (KF) in children living in the emerging world. We used registry data to provide a global overview of the underlying disease spectrum in children commencing kidney replacement therapy (KRT).

METHODS: We analyzed KF causes among 23,620 children and adolescents commencing maintenance KRT in 80 countries, using data from the IPNA Global KRT Registry (including ESPN/ERA Registry), the International Pediatric Dialysis Network (IPDN), the United States Renal Data System (USRDS), and the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA). The analysis considered …

Tribute To The Dead Is Honor To The Living: Uncovering The Evolution Of Funerary Monuments In Black Cemeteries Throughout Charleston, Sc, Lorena Garrod

All Theses

Black burial grounds throughout Charleston have long been understudied, and their funerary architecture even less so. Within the City of Charleston’s Urban Growth Boundary, many undocumented Black cemeteries are threatened by development. Previous scholarship is scant, as these sites have gone without dedicated research for many years. As awareness of their historical significance grows, attempts are being made to document and understand Black burial grounds, both within the context of Charleston, but more so within the context of the descendant communities these burial grounds serve. To this end, this research asked the question, “What material and formal shifts can be …

The Geography Of Race: A Spatial Analysis Of Free People Of Color In The City Of Charleston (1790-1861), Alexandra Ullman

All Theses

In Charleston, South Carolina, for all but one year from 1790 to 1860, the enslaved and free Black population outnumbered that of the white. Through manumission, the process of an enslaved person gaining their freedom, the free Black population grew substantially and reached a peak in South Carolina during the nineteenth century. This large community of free people of color (FPOC), shifted the social climate by upsetting the balance of white power, thus increasing racial conflict, tension, and legislation that aimed to control the movement of FPOC.

Despite FPOC comprising a significant portion of the total population of Charleston, there …

The Whaler’S Empire: Industry, Environment, And American Expansion In The Pacific Ocean, Andrew J. Hiner

All Theses

The American whaling industry reached its peak in the mid nineteenth century, numbering over seven hundred vessels and reaching from the South Atlantic to Arctic Oceans. The rise of this maritime trade coincided with the emergence of the nation’s industrial revolution at home, a revolution which employed the product of whaling—namely whale oil—as a lubricant for machinery. Historians have often overlooked the use of this commodity in manufacturing, focusing instead on whale oil’s use as an illuminant. Examining the relation between the whaling and manufacturing industries offers new insights into how ocean environments played a role in domestic production. It …

Commodified Suffering: True Crime Podcasting, Gendered Violence, And The Culture Of Apathy”, Alaysia Lewis

All Theses

This study examines the linguistic patterns of true crime podcast hosts, as well as what potential impacts these language choices have on audiences. Through an analysis of literature regarding true crime media, listener motivations, and the effects of true crime media consumption on listeners, themes of apathy and desensitization, female pain as entertainment, and commodification of harm against women were found. This serves as a case study of the popular true crime podcast Crime Junkie, observing the language patterns used by the hosts before and after their involvement in a controversy that included accusations of plagiarism, commodification, and unethical journalistic …

Identity, Party, And Politics: A Discourse Analysis Of Democratic Elites In Pod Save America, Geneva Lei P. Luteria

All Theses

The rise of popular podcasts has shaped public discourse and influenced millions worldwide on how they ought to think, imagine, and act about controversial subjects. Podcasts create an avenue for stories about power and technology to co-create a narrative that viewers buy into. This thesis analyzes one of these essential podcasts, Pod Save America, in how Democratic elite guests approach identity politics, a phenomenon best described as advocacy based on one position’s in society. I begin the thesis by considering the differences in scholarly interpretation of how identity politics functions conceptually and practically. Then, I integrate ideas about how …

Romanticizing 'Monsters': Sexualized Digital Fandom Of The Menendez Brothers, Kimberly M. Brooks

All Theses

This study was conducted to explore the expressions of sexualized fandom and parasocial relationships within the context of true crime. The Menendez Brothers were chosen as the case to focus on due to the Netflix dramatization ‘Monsters: The Lyle and Erik Menendez Story’ release and online popularity. Reddit was the platform chosen for data collection because of the longstanding presence of true crime followers participating in dialogue on the platform. The r/MenendezBrothers thread was chosen to collect data from because of its large following and large number of weekly contributions. Sprinklr, the social media analytics platform, was employed to gather …

Communicating Sustainability: Exploring How Nongovernmental Organizations In Ghana Use Internal Communication For Philanthropic Development, Ama A. Assenso-Onyinah

All Theses

Internal communication is an important area in organizational structure. In the NGO sector, it can be used strategically to navigate resource constraints. The main objective of this study is to highlight the importance of internal communication and its role in navigating resource dependency in NGOs in Ghana. In recent times, NGOs in Ghana have been struggling as funding drops, especially after the stop order by the US government on USAID. Using qualitative data drawn from six participants who work with NGOs in Ghana, the study identified internal communication as a foundational structure to philanthropic partnerships. Through the lens of resource …

Women In The Chancery Court Of Maryland From 1669 To 1679, Emily A. Cole

All Theses

This project examines women who appeared in the Chancery Court of Maryland from 1669 to 1679. This thesis used the Archives of Maryland Online and the volume of proceedings of the Chancery Court. Across the three chapters, I argue that historians have largely ignored these proceedings, and that women did not appear in court out of empowerment but rather out of legal duty and requirement. I examined how these women appeared in both their legal status and the types of positions they held. This included the life cycle women typically followed from wife to widow to remarriage. They also appeared …

Rainbow Row: Tourism, Color, And The Making Of A Civic Icon, 1930s – 1960s, Samantha E. Threlkeld

All Theses

This thesis investigates the emergence of Rainbow Row in Charleston, South Carolina, as a civic and tourism icon through an integrated analysis of visual culture, preservation governance, and material evidence. While Rainbow Row has become one of the most recognizable images of Charleston’s historic district, the chronology and cultural mechanisms through which its colorful façades were produced, interpreted, and disseminated have remained largely unstudied. This study addresses the primary research question: How Rainbow Row’s painted façades were leveraged in marketing and tourism narratives between the 1930s and the 1960s, and what those representations reveal about the construction of Charleston’s civic …

“Tyranny” As Concept: Semantic Change And The Formation Of Colonial Political Consciousness In The New Hampshire Gazette, 1756–1783, Antonio Worley

All Theses

Historians of the American Revolution have frequently viewed terms such as tyranny as a stable ideological category, associated with corruption and resistance to arbitrary power. This thesis instead reconceptualizes ‘tyranny’ as an evolving and historically contingent Koselleckian concept. Drawing on a comprehensive analysis of the New Hampshire Gazette from 1756 to 1783, this study combines close reading with computational methods, including word frequency analysis and word embeddings, to chart the evolution of the semantic field surrounding “tyranny” over time.

Prior to the Stamp Act of 1765, ‘tyranny’ was used primarily in a religious and moral framework which was shaped by …

The Development And Evaluation Of A Group Therapy Program For Perinatal Loss In Rural Appalachia, Hope O'Neill

Electronic Theses and Dissertations

Perinatal loss can have vast adverse psychological consequences and has limited psychotherapeutic options to assist with those outcomes. Currently, there is no gold standard psychotherapy for the treatment of perinatal grief. Group therapy has proven to be an effective modality for various populations and has been shown to be beneficial for perinatal loss and the subsequent psychological outcomes. This study utilized a previously conducted systematic review to develop and evaluate a group psychotherapy for perinatal loss. The ten sessions of the group were completed by two participants and several constructs were explored pre- and post-intervention: grief, depression, anxiety, post-traumatic stress, …

Academic Self-Efficacy Of Black, White, And Hispanic Students Pursuing Professional Education Degrees And Licensure At An Hbcu In Midwest Ohio, Nathan Boles

Electronic Theses and Dissertations

The purpose of this comparative quantitative study was to determine, using three self-efficacy scales, General Self-Efficacy (GSE), Academic Self-Efficacy (ASE), and Educational Self-Efficacy (ESE), the differences in academic and educational self-efficacy among Black, White, and Hispanic students seeking a Professional Education degree and licensure at a Historically Black College and University in Midwest Ohio. Pre-service students’ self-efficacy and goal commitment can affect their likelihood of graduating with a license and may directly affect the number of novice teachers of color in the classroom. The literature examines factors that disrupt students’ self-efficacy, academic confidence, and persistence through the theoretical frameworks of …

Stochastic Universal Differential Equations For Epidemiological Modeling: Uncertainty Quantification In Disease Transmission Dynamics, Alice Menaya Armah-Bonney

Electronic Theses and Dissertations

Epidemic forecasting requires not only predictions of expected case counts, but also quantification of uncertainty, although existing surrogate modeling frameworks for agent-based models remain fundamentally deterministic. In this thesis a Stochastic Universal Differential Equation framework is presented that extends the deterministic Universal Differential Equation approach by incorporating a learnable stochastic diffusion term, enabling calibrated probabilistic forecasts while preserving the mechanistic interpretability and computational efficiency of the deterministic baseline. In doing so, a two-phase training algorithm is introduced to ensure stable convergence and the framework is validated against the ensemble output from ExaEpi, an exascale agent-based model of a COVID-19 outbreak …

Perceptions Of Effective Co-Teaching Partnerships In High School Inclusive Classrooms, Korri-Lee S. Wood

Electronic Theses and Dissertations

The purpose of this qualitative study was to examine the characteristics and contextual factors that general education and special education teachers perceive as essential for effective co-teaching partnerships in high school inclusive classrooms. The study, which involved in-depth interviews with general and special education teachers in co-teaching partnerships, was conducted within a constructivist paradigm to shed light on interpersonal, communicative, and systemic variables that contribute to a positive, productive co-teaching experience. Purposeful sampling was employed to select general and special education teachers who were part of co-teaching partnerships. Thematic analysis was used to analyze data from semi-structured interviews, and an …

University Student Mental Health: Service Utilization, Equity Gaps, And Strategies To Improve Access, Richard Mutua Kilonzo

Electronic Theses and Dissertations

Student mental health and access to care are pressing concerns in higher education. This study assesses mental health outcomes and access to campus mental health services at East Tennessee State University. Survey data from the 2023–2024 Healthy Minds Study were analyzed to report the prevalence of depression, anxiety, and suicidal ideation across the student population. The study evaluates disparities in these outcomes and barriers to care across student groups, with particular attention to equity-impacted students, especially sexual and gender minority students.

Findings indicate widespread psychological distress alongside persistent barriers, including long wait times, limited-service availability, and stigma-related concerns. These barriers …

Bergsonian Blend: Subjective Temporality Within Modernist Aesthetics Of Mental Illness, Lydia Victoria Gervais

Electronic Theses and Dissertations

Henri Bergson was a modernist French philosopher who wrote extensively on the topic of the lived experience of time, which he called durée, or duration. His contemporary, Sigmund Freud, was developing psychoanalytic theory in a growing field of psychological study, which serves as a prominent ancestor to modern psychiatry and current psychoanalytical literary studies. Fiction writers of the 1900s absorbed the zeitgeist of melded chronology and consciousness, interweaving themes of time and trauma in their works. Utilizing Henri Bergson’s durée as a philosophical framework, I examine the moralization of time-consciousness in connection with mental illness and investigate representations of …

The Influence Of Intervention Strategies On Students With Disabilities Who Exhibit Challenging Behaviors In Rural Public Schools: Teacher Perceptions, Ben B. Robertson

Electronic Theses and Dissertations

This phenomenological qualitative study addressed rural teachers' perceptions of the influence of intervention strategies on students with disabilities who exhibit challenging behaviors. The purpose of this study was to examine teachers’ perceptions of the effect of intervention strategies on academic achievement, student behavior outcomes, and teacher self-efficacy through the lens of Bandura’s Social Cognitive Theory. This theory is a complex, dynamic interaction among people, their behaviors, and their environments. Data collection included 14 individual interviews, conducted on Zoom with educators from one school district in Southern Virginia, including seven general education teachers and seven special education teachers. Data analysis strategies …

Machine-Learning Landslide Susceptibility And Runout Modeling In The Nolichucky River Gorge After Hurricane Helene, Grace Braver

Electronic Theses and Dissertations

Extreme rainfall from Hurricane Helene (September 2024) triggered widespread landslides across the southern Appalachian region, highlighting the need for rapid landslide susceptibility assessments that capture both landslide initiation and downstream runout. Traditional susceptibility models often focus solely on initiation zones, limiting their ability to identify which slopes will generate destructive landslides or where material will travel. This study addresses that gap by (1) integrating Geographic Information System (GIS)-based machine learning susceptibility modeling using ArcGIS Pro: Maximum Entropy (MaxEnt) and Random Forest-Based and Boosted Classification and Regression (FBBC) and (2) the U.S. Geological Survey (USGS) Grfin (Growth, Flow, and Inundation) runout …

Media Portrayal Of High-Profile Female Victims Of Sexual Harassment, Chinenye Nwaneri

Electronic Theses and Dissertations

This rhetorical study investigated how the Nigerian media portray high-profile female victims of sexual harassment. The research was undertaken in response to concerns that media narratives often reinforce gender stereotypes and influence public perceptions of victims. Focusing on the sexual harassment allegations made by senator Natasha Akpoti-Uduaghan against Senate president Godswill Akpabio, the study analyzed newspaper coverage from Daily Trust and Vanguard between February and December 2025. Using Critical Discourse Analysis within the framework of Feminist Media Theory, the research examined how language and framing shaped the representation of the female accuser. The findings reveal that media coverage constructed the …

Wrky Transcription Factors: Integral Regulators Of Defence Responses To Biotic Stress In Crops, Dongjiao Wang, Ruize Zhang, Wenhui Zou, Yuanyuan Zhang, Wanying Zhao, Tingting Sun, Qibin Wu, Zheng Qing Fu, Youxiong Que

Faculty Publications

Crops are continually challenged by biotic stresses, including fungal, bacterial and viral pathogens and insect pests, which cause substantial yield and quality losses worldwide. WRKY transcription factors constitute a plant-specific and functionally diverse family that is central to immune regulation. Recent advances in genomic resources and multi-omics approaches have accelerated the identification and functional characterisation of WRKYs in crops. This review summarises the structural features and classification of WRKY genes and their genome-wide distribution across crop species. It also synthesises WRKY-centred regulatory modules that mediate resistance to major classes of biotic stress. In antifungal defence, WRKYs reinforce pattern- and effector-triggered …

Risk Factors For The Development Of Food Allergy In Infants And Children: A Systematic Review And Meta-Analysis, Nazmul Islam, Alexandro W L Chu, Falana Sheriff, Farid Foroutan, Gordon H Guyatt, Romina Brignardello-Petersen, Paul Oykhman, Alfonso Iorio, Ariel Izcovich, Katherine M Morrison, Yetiani Roldan Benitez, Rachel J Couban, Dorota Borovsky, Yiming Zhang, Leonardo Ologundudu, Keerthana Pasumarthi, Syed Fahad Farooq, Kyle Tong, Wang-Choi Tang, Haseeb Faisal, Muhammad Faran Khalid, Mohammad Saad Asif, Shannon French, Susan Waserman, R Sharon Chinthrajah, Hugh A Sampson, S Shahzad Mustafa, Jay A Lieberman, Kirsi M Järvinen, Sally Bailey, Philippe Bégin, Scott H Sicherer, Jennifer Gerdts, Melanie Carver, Lynda Mitchell, Kelly Cleary, Matthew J Greenhawt, Julie Wang, Aikaterini Anagnostou, Marcus S Shaker, Anita Chandra-Puri, Patricia C Fulkerson, Robert A Wood, Derek K Chu

Faculty, Staff and Students Publications

Importance: The incidence and risk (predictive) factors for early life food allergy development remain uncertain.

Objective: To estimate the incidence and quantify risk factors for food allergy development.

Data sources: MEDLINE and Embase were systematically searched to January 1, 2025. Data were analyzed from June 1, 2025, to November 25, 2025.

Study selection: Incidence estimates included studies confirming food allergy via food challenge. Risk factor analyses included cohort, case-control, and cross-sectional studies in any language assessing children younger than 6 years using multivariable analyses.

Data extraction and synthesis: Paired reviewers independently extracted data. Random-effects meta-analyses pooled incidence and adjusted odds …

Bridging Access Gaps In Radiotherapy: Knowledge-Based Planning In A Resource-Constrained Clinical Setting, Milton E Ixquiac Cabrera, Erick O Montenegro, Matthew Schmidt, Baozhou Sun, James A Kavanaugh, Taoran Li, Angel Velarde, Vicky De Falla, Francisco Reynoso

Faculty, Staff and Students Publications

Background/purpose: Radiotherapy access in low- and middle-income countries (LMICs) is severely limited by shortages of trained personnel, high patient volumes, and large waiting times for manual treatment planning. Knowledge-based planning (KBP) has shown promise in high-income settings, yet its feasibility in resource-constrained environments remains underexplored. This study aimed to evaluate the feasibility of adapting a KBP model developed at a high-income institution for clinical use at Liga Nacional Contra el Cáncer (LNCC) in Guatemala for gynecological radiotherapy planning.

Materials and methods: A RapidPlan KBP model (Varian-Siemens Healthineers, Palo Alto, CA, USA) originally developed at Washington University in St. Louis using …

Adhesion G Protein-Coupled Receptors, Tobias Langenhan, Garret R Anderson, Demet Araç, Gabriela Aust, Monserrat Avila-Zozaya, Sofie Morsing Bagger, Patrick Barth, Sandra Berndt, Stephen C Blacklow, Beatriz Blanco-Redondo, Antony A Boucard, James P Bridges, Lara-Sophie Brodmerkel, Kathleen M Caron, Yin Kwan Chung, Andrew N Dates, Virginea De Araujo Farias, Daniel Del Toro, Joseph G Duman, Felix B Engel, David M Favara, Caroline J Formstone, Chaoyu Fu, Alain Garcia De Las Bayonas, Anastasia Georgiadi, David E Gloriam, Randy A Hall, Jörg Hamann, Peter W Hildebrand, Cheng-Chih Hsiao, Bill X Huang, Jonathan A Javitch, Hee-Yong Kim, Robert J Kittel, Gunnar Kleinau, Richard Leduc, Ines Liebscher, Hsi-Hsien Lin, Joshua Linnert, Marie-Gabrielle Ludwig, David C Martinelli, Signe Mathiasen, Daniel Matúš, Mariam Melkumyan, Ana L Moreno-Salinas, Jan Mulder, Michael A Nash, Kasturi Pal, Daniel T Pederick, Nicole A Perry-Hauser, Xianhua Piao, Yu-Qi Ping, Dimitris G Placantonakis, Fabian Pohl, Simone Prömel, Mette M Rosenkilde, Laurent Sabbagh, Richard C Sando, Patrick Scheerer, Torsten Schöneberg, Elena Seiradake, Mareike Selcho, Florian Seufert, Abhishek K Singh, Georgios Skiniotis, Katja Spiess, Norbert Sträter, David Strutt, Thomas C Südhof, Jinpeng Sun, Gregory G Tall, Doreen Thor, Douglas G Tilley, Kimberley F Tolias, Mario Vallon, Erwin G Van Meir, Benoit Vanhollebeke, Giselle R Wiggin, Uwe Wolfrum, Jie Yan, Nathan A Zaidman, Yimin Zou, Nicole Scholz

Faculty, Staff and Students Publications

Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive …

Adhesion G Protein-Coupled Receptors, Tobias Langenhan, Garret R Anderson, Demet Araç, Gabriela Aust, Monserrat Avila-Zozaya, Sofie Morsing Bagger, Patrick Barth, Sandra Berndt, Stephen C Blacklow, Beatriz Blanco-Redondo, Antony A Boucard, James P Bridges, Lara-Sophie Brodmerkel, Kathleen M Caron, Yin Kwan Chung, Andrew N Dates, Virginea De Araujo Farias, Daniel Del Toro, Joseph G Duman, Felix B Engel, David M Favara, Caroline J Formstone, Chaoyu Fu, Alain Garcia De Las Bayonas, Anastasia Georgiadi, David E Gloriam, Randy A Hall, Jörg Hamann, Peter W Hildebrand, Cheng-Chih Hsiao, Bill X Huang, Jonathan A Javitch, Hee-Yong Kim, Robert J Kittel, Gunnar Kleinau, Richard Leduc, Ines Liebscher, Hsi-Hsien Lin, Joshua Linnert, Marie-Gabrielle Ludwig, David C Martinelli, Signe Mathiasen, Daniel Matúš, Mariam Melkumyan, Ana L Moreno-Salinas, Jan Mulder, Michael A Nash, Kasturi Pal, Daniel T Pederick, Nicole A Perry-Hauser, Xianhua Piao, Yu-Qi Ping, Dimitris G Placantonakis, Fabian Pohl, Simone Prömel, Mette M Rosenkilde, Laurent Sabbagh, Richard C Sando, Patrick Scheerer, Torsten Schöneberg, Elena Seiradake, Mareike Selcho, Florian Seufert, Abhishek K Singh, Georgios Skiniotis, Katja Spiess, Norbert Sträter, David Strutt, Thomas C Südhof, Jinpeng Sun, Gregory G Tall, Doreen Thor, Douglas G Tilley, Kimberley F Tolias, Mario Vallon, Erwin G Van Meir, Benoit Vanhollebeke, Giselle R Wiggin, Uwe Wolfrum, Jie Yan, Nathan A Zaidman, Yimin Zou, Nicole Scholz

Faculty, Staff and Students Publications

Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive …

Mif-Cd74 Signaling Drives Immune Modulation In Medulloblastoma, Benjamin Draper, Zhen You, Dean Thompson, Xu Guo, Alaide Morcavallo, Diego Chillon Pino, Carlos Lorenzo Gido Nery, Sumana Shrestha, Chantelle E Bowers, Courtney Himsworth, Alberto Delaidelli, Bethany Remeniuk, Sonia Morlando, Brandon Wade, Freya Gordon, Yara Sanchez-Corrales, Bei Hopkins, Natalie Monteiro, Darren Locke, Miao Liu, Jacob Torrejon Diaz, Kevin Greenslade, Barbara Martins Da Costa, Karen Barker, Colin Kwok, Olumide Ogunbiyi, Anya Fletcher, Stacey Richardson, Carlos Custodia, Rafael Roque, Thomas Jackson, Regan Barfoot, Sergi Castellano, Rebecca M Hill, Olivier Saulnier, Thomas S Jacques, Michael D Taylor, Claudia C Faria, Olivier Ayrault, Poul H Sorensen, John Anderson, Louis Chesler, L Frank Huang, Steven C Clifford, Laura K Donovan

Faculty, Staff and Students Publications

Background: Relapsed medulloblastoma remains a significant therapeutic challenge as it is near universally fatal. The tumor microenvironment of medulloblastoma plays a critical role in tumor progression, influencing tumor growth, immune evasion, and therapeutic resistance. We hypothesized that defining tumor-immune interactions in diagnostic and relapsed medulloblastoma may uncover mechanisms of immune evasion and identify novel therapeutic targets.

Methods: We analyzed paired primary and recurrent RNA-sequencing data from 140 medulloblastoma patients to profile immune cell composition and validate spatial relationships within the TME. To identify key tumor-immune interactions, we developed a novel algorithm to detect receptor-ligand pairs using single-cell RNA-sequencing data. These …

Weaving Ideology: Textiles In Florentine And Venetian Painting Of The Cinquecento, Ruben Verità

Art and Art History Honors Projects

Renaissance art historical scholarship has largely ignored the political and cultural significance woven into the representation of textiles, as well as their communicative potential in paintings. In this study, I examine how textiles in their various forms carry the potential to go beyond their normative categorization as decoration. Through a comparative analysis of the paintings produced in two politically distinct polities—Florence and Venice—during the sixteenth century, I integrate Louis Althusser’s theory of ideology and Michael Baxandall’s period eye to elucidate how painted fabric was not the representation of a passive decorative ornament. Rather, it was an active and legible proxy …

Fructose: Metabolic Signal And Modern Hazard, Richard J Johnson, Miguel A Lanaspa, Dean R Tolan, Marcus D Goncalves, Samir Softic, Kimber L Stanhope, Laura G Sánchez-Lozada, Mark A Herman, Joshua D Rabinowitz

Faculty, Staff and Students Publications

There is much interest in the role of sweeteners such as table sugar (sucrose) and high-fructose corn syrup in obesity and metabolic disease. Both sweeteners consist of glucose and fructose, two six-carbon isomeric sugars. Whereas glucose ingestion may promote obesity through its effects to stimulate insulin secretion, fructose has unique metabolic effects that promote triglyceride synthesis and fat accumulation. These effects arise from fructose's well-known role as a signal of metabolic plenty. Under modern conditions of overnutrition, chronic excess fructose drives features of metabolic syndrome. Emerging evidence further links fructose to cancer and dementia. Here we review the biochemical, molecular …

Inclusion And Equity In Early Childhood Special Education, Maranda Martinez

Electronic Theses, Projects, and Dissertations

The present study examined equity and inclusion in early childhood special education through the lived experiences of administrators, educators, and caregivers. Despite decades of legislation, preschool students of color with dis/abilities continue to experience disproportionate identification for special education, exclusionary discipline, and limited access to inclusive settings (DHHS & DE, 2023; NCD, 2018). Grounded in Disability Critical Race Theory (DisCrit), this study explores how intersecting systems of racism and ableism shape early childhood educational access and opportunity.

Guided by a phenomenological approach with a transformative paradigm, data were collected through semi-structured interviews with eighteen participants including administrators, early childhood special …

Impact Of Affirmative Care For Lgbtqsia2+ Youth In Foster Care, Jody Brown

Electronic Theses, Projects, and Dissertations

One of the major challenges within the child welfare system is that LGBTQSIA2+ youth often face discrimination, stigma and have limited access to mental health services. Although previous research has identified LGBTQSIA2+ youth being overrepresented in foster care, they face distinctive vulnerabilities that are inadequately addressed in present policies within child welfare practices. Despite experiencing higher levels of placement instability and being at greater risk of anxiety, depression and psychological distress, there remain gaps in tangible support and evaluating the effectiveness of intersectionality of lived experiences of LGBTQSIA2+ youth in the foster care. The purpose of this qualitative phenomenological research …