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Articles 65521 - 65550 of 1196180
Full-Text Articles in Entire DC Network
An Adaptive Neutrosophic Large Neighborhood Search And Its Application, Jun Jiang, Fangwei Zhang, Yiying Pan, Rui Wang, Zhu Han
An Adaptive Neutrosophic Large Neighborhood Search And Its Application, Jun Jiang, Fangwei Zhang, Yiying Pan, Rui Wang, Zhu Han
Neutrosophic Sets and Systems
the improvement degree in the new solution, which causes fuzziness and uncertainty in the operator score. To solve the aforementioned problem, the main innovation of this study is to propose an adaptive neutrosophic large neighborhood search (ANLNS). Specifically, the main work is as follows. Firstly, the number of times each operator scores are quantified by constructing NSs, thereby analyzing algorithm performance and preventing the idealization of scores. Secondly, a novel neutrosophic utility function and score function are proposed to assign an appropriate score for the operator within a reasonable interval. Finally, the effectiveness and robustness of the proposed ANLNS is …
Analyzing Interdisciplinary Education In General Medicine Using Smarandache's Multivalued Logic Hypothesis Theory And Plithogenic Probability, Dolores Hernandez De La Cantera, Rosangela Caicedo Quiroz, Mairim Lago Queija, Jeanntte Rodriguez Gonzalez, Maikel Y. Leyva Vazquez
Analyzing Interdisciplinary Education In General Medicine Using Smarandache's Multivalued Logic Hypothesis Theory And Plithogenic Probability, Dolores Hernandez De La Cantera, Rosangela Caicedo Quiroz, Mairim Lago Queija, Jeanntte Rodriguez Gonzalez, Maikel Y. Leyva Vazquez
Neutrosophic Sets and Systems
Smarandache extended the concept of falsifiability to include hypotheses that involve multiple values. Smarandache's extension of classical logic introduces Partial Falsifiability within multi-valued logic, which allows for the inclusion of partial truth values, uncertainties, and false values, unlike traditional falsifiability which only classifies hypotheses as completely true or false. Using this approach this study investigates specifically the concept of interdisciplinarity in the field of integral general medicine, with a specific emphasis on the integration of nursing procedures. The method employs sentiment analysis of scientific questions using the Consensus tool and plithogenic statistics to assess complex hypotheses. The findings indicate that …
Addressing The Mathematical Achievement Gap Through Improvements In School Facilities: The Case Of Fort Bend Isd School District In Texas, Damian K. Viltz
Addressing The Mathematical Achievement Gap Through Improvements In School Facilities: The Case Of Fort Bend Isd School District In Texas, Damian K. Viltz
All Dissertations
In 1966, Americans were introduced to the term achievement gap by James S. Coleman, a Johns Hopkins sociologist. Coleman et al.’s (1966) study explained most of the gap between the achievement of America’s White and Black students. Since that study was published, scholars have identified strategies to close the achievement gap. Accordingly, my research investigated the possibility of using the quality of school facilities as a potential strategy to enhance learning equity across racial categories. My findings may fuel policies targeting the development of local communities through inclusive learning achievements.
My empirical methodology was sustained by an expanded theoretical framework …
What Are The Potential Drivers Of Nil Perception Among Student-Athletes?, Fred E. Washington
What Are The Potential Drivers Of Nil Perception Among Student-Athletes?, Fred E. Washington
All Dissertations
This dissertation investigated the impact of the NCAA's Name, Image, and Likeness (NIL) policy on student-athletes' college choice. By synthesizing existing academic literature on NIL and college choice models, the study established a comprehensive theoretical framework. The research employed quantitative methods, gathering data through a survey to explore their perceptions and experiences with NIL. The analysis revealed that NIL significantly influenced college selection, with factors such as scholarship type, sport type, and geographic background of the athletes playing crucial roles. Interestingly, most respondents were aware of NIL policies before starting their college search. Demographic insights showed a slight female majority …
Optimization Of Solar Energy Efficiency Using Neural Network Controllers With Direct Current Converters, Kasim Ali Mohammad
Optimization Of Solar Energy Efficiency Using Neural Network Controllers With Direct Current Converters, Kasim Ali Mohammad
All Dissertations
Photovoltaic (PV) systems offer a renewable energy source by converting sunlight into electricity. This dissertation enhances PV system performance using advanced control mechanisms and DC-DC converters. PV systems, influenced by variables such as irradiance and temperature, require efficient Maximum Power Point Tracking (MPPT) for optimal energy conversion. Traditional MPPT methods like the Perturbation and Observation (P&O) algorithm often struggle with rapidly changing conditions. While Artificial Neural Networks (ANN) and Recurrent Neural Networks (RNN) have been explored for control purposes, this research applies Positive Output Super Lift Luo (P/O SLL), and Ultra Lift Luo (ULL) converters integrated with ANN and RNN …
Sustainable Energy-Generating Pads As Future Alternative Energy Source For Road Infrastructure, Kazi Meharajul Kabir
Sustainable Energy-Generating Pads As Future Alternative Energy Source For Road Infrastructure, Kazi Meharajul Kabir
All Dissertations
The world is experiencing a significant environmental crisis due to its dependence on fossil fuels for energy and transportation, which is leading to global warming and climate change. The global climate crisis demonstrates the urgent need to transition to renewable energy sources, making research on sustainable energy-generating systems increasingly important. PZT cells present an alternative energy-generating source but face challenges such as brittleness, low-frequency operation, and high-temperature sensitivity, which cause performance degradation. Additionally, issues like impedance matching and fluctuations in PZT-based energy systems contribute to significant energy generation losses. Research into composite materials, design optimizations, temperature-stabilized materials, fabrication techniques, and …
Signatures Of Selection, Gene Flow, And Genetic Drift On The Genomes Of A Recent Avian Radiation, Flor Brigitte Hernandez Camacho
Signatures Of Selection, Gene Flow, And Genetic Drift On The Genomes Of A Recent Avian Radiation, Flor Brigitte Hernandez Camacho
Open Access Theses & Dissertations
Speciation is not a discrete event but rather a gradual process that occurs along a continuum. Initially, populations remain genetically and reproductively connected, but they become reproductively isolated as the process of speciation progresses. Advances in DNA sequencing technology has helped our understanding of the processes that contribute to changes in the genetic composition of populations over the progression of speciation, also known as drivers of evolution (i.e. genetic drift, mutation, selection, and gene flow). Among them, hybridization, or the interbreeding between distinct lineages, is increasingly recognized as a natural process that can have significant consequences to the speciation process. …
Method Development For The Quantification Of Critically Valuable Elements In Permian Basin Produced Waters, Carley Oliver
Method Development For The Quantification Of Critically Valuable Elements In Permian Basin Produced Waters, Carley Oliver
Open Access Theses & Dissertations
Produced waters (PW) are a major byproduct of the oil and gas industrial hydraulic fracturing processes that create a major waste disposal issue with a need for disposal, treatment, and reuse method developments. The current primary disposal method is subsurface injection, which can lead to high pressures in the subsurface. PWs are often highly saline from mineral leaching due to long residence in subsurface reservoirs. According to the USGS National Minerals Information Center, bromine, calcium chloride, iodine, lithium, magnesium, and sodium chloride have been found in and extracted from these domestic subsurface brines, suggesting that there may be other economically …
Establishment Of A Novel Prairie Vole (Microtus Ochrogaster) Sars-Cov-2 Infection And Transmission Model, Stephanie Rebecca Kehl
Establishment Of A Novel Prairie Vole (Microtus Ochrogaster) Sars-Cov-2 Infection And Transmission Model, Stephanie Rebecca Kehl
Open Access Theses & Dissertations
Considering that the number of SARS-CoV-2 cases and deaths continues to increase three years after the onset of the pandemic, the need for animal models to study disease pathology and test antiviral effectiveness remains paramount. Prairie voles offer unique advantages as an infection model, such as mirroring human social behavior, including pair bonding and biparental offspring rearing, having inducible estrus and ovulation cycles, and not being overly domesticated. Based on the sequence homology of the vole ACE2 receptor to that of other species that are susceptible to SARS-CoV-2, such as the ferret and hamster, we hypothesized that the vole ACE2 …
Essays On Esg, Trang Pham
Essays On Esg, Trang Pham
Open Access Theses & Dissertations
The dissertation consists of two essays. The first essay examines the effect of local corruption on a firmâ??s environmental, social, and governance (ESG) performance by taking into account the role of liberalism in each state. I propose that since liberals are generally more environmentally and socially concerned than conservatives, ESG performance of firms located in states with liberal views will be less negatively impacted by the local corruption than conservative-leaning states. The results provide some support for my projection. I find that for a particular level of corruption, firms located in states with liberal leaning views exhibit better ESG performance …
“We Need To Wake Our World Up”: Collegiate Athletes’ Communicative Constitution Of Activism, Lillian B. Feder, Diane L. Jackson, Sean M. Eddington
“We Need To Wake Our World Up”: Collegiate Athletes’ Communicative Constitution Of Activism, Lillian B. Feder, Diane L. Jackson, Sean M. Eddington
College of Communication Faculty Research and Publications
This study examines National Collegiate Athletic Association (NCAA) Division I athletes’ experiences engaging in activism through the lens of the communicative constitution of organizations. Specifically, we investigated the modalities and approaches collegiate athletes employ in their activism. Findings indicate that collegiate athletes gravitate toward online and offline channels, and fiscal, ideological, and organizational activities as modalities for their activist efforts. We also uncovered that collegiate athletes’ inclination to call-in versus call-out is characterized by their willingness to engage with the recipients of their cause-related messages. This inquiry demonstrates the discursive and material nature of collegiate athlete activism, highlighting the call-in …
Enhancing Ethical Competency: A Review Of Ethical Instruction For Law Enforcement, Alexis Turner
Enhancing Ethical Competency: A Review Of Ethical Instruction For Law Enforcement, Alexis Turner
Electronic Theses and Dissertations
As public confidence in policing has dropped, demand for ethical behavior from law enforcement officers has grown, and correspondingly, a better understanding of ethics training and ethical acquisition processes has become paramount. Though much literature exists on related topics, understanding of the ethics training for law enforcement officers as it currently exists, has remained murky. This research aimed to gain a better understanding of ethics training for law enforcement in the United States, and as such, to fill the aforementioned gap in the literature. Four research questions were explored in this study including the understanding of current pre-service and in-service …
The Adaptation Wedge: Capacity-Building Scenarios For India’S Cities, Jagan Shah
The Adaptation Wedge: Capacity-Building Scenarios For India’S Cities, Jagan Shah
Midwest Social Sciences Journal
The increasing frequency and severity of floods, heat waves, and storm surges impacting global cities, combined with the growing morbidity in public health, necessitates prompt and effective climate action. Adaptation and mitigation require adequate and appropriate institutional, technical, and societal capacities—all of which are in short supply in most low- and middle-income country cities that are experiencing growth while suffering vulnerabilities. Although national governments are alerted to climate risk and the imperatives of planning, financing, and managing climate transitions, their responses to capacity constraints and approaches to capacity building display neither urgency nor scale. We use a scenario-building methodology to …
Notes On The Future Possibilities Of Engaged Anthropological Research: Why Decolonizing Anthropology Needs Black Diasporic Feminist Theory And Methodologies, Meryleen Mena
Midwest Social Sciences Journal
While in the past decade there have been more ethnographic accounts that shed light on minoritized stories and demystify the specific challenges that women and femmes experience during their research, much is desired to prepare students and junior scholars from marginalized identities for fieldwork research. Reflecting on a moment of precarity in the context of pre-impeachment São Paulo, I explain why the integration of Black diasporic feminist thought, method, and praxis is critical to further decolonizing efforts in anthropology. Beyond reflection, this narrative calls for sustained politically active engagement to establish an anthropology of liberation.
Unveiling Key Features: A Comparative Study Of Machine Learning Models For Alzheimer's Detection, Cailean Bushnell
Unveiling Key Features: A Comparative Study Of Machine Learning Models For Alzheimer's Detection, Cailean Bushnell
All Graduate Reports and Creative Projects, Fall 2023 to Present
This thesis rigorously evaluates the application of an array of natural language processing (NLP) techniques and machine learning models to identify linguistic signatures indicative of dementia, as sourced from the DementiaBank Pitt corpus. Utilizing a binary classification paradigm, this study meticulously integrates sophisticated embedding methods—including Doc2Vec, Word2Vec, GloVe, and BERT—with traditional machine learning algorithms such as Random Forest, Multinomial Naïve Bayes, ADA boost, KNN classifier, and Logistic Regression, alongside deep learning architectures like LSTM, Bi-LSTM, and CNN-LSTM. The efficacy of these methodologies is evaluated based on their capacity to differentiate between transcribed speech impacted by dementia and that from control …
Sustainable Waste-To-Bioproducts Engineering Center Laboratory Safety Project, Claudine Mock
Sustainable Waste-To-Bioproducts Engineering Center Laboratory Safety Project, Claudine Mock
All Graduate Reports and Creative Projects, Fall 2023 to Present
Laboratory accidents are common in teaching and research labs; these accidents can be injurious or even fatal. The consequences of each type of laboratory accident are different based on the activities performed and the hazardous materials used in each facility. However, the most common issue related to laboratory accidents is the lack of proper safety measures (e.g., poor handling of hazardous materials, not reporting incidents immediately, etc.). This project aimed to establish and strengthen best practices and procedures to ensure laboratory safety at the Utah State University Sustainable Waste-to-Bioproducts Engineering Center. To achieve this goal, different practices and measures were …
Introduction To Landscape Architecture State Standards And Curriculum For Utah High Schools, Joseph Pancoast
Introduction To Landscape Architecture State Standards And Curriculum For Utah High Schools, Joseph Pancoast
All Graduate Reports and Creative Projects, Fall 2023 to Present
Utah State University (USU) offers a successful Introduction to Landscape Architecture class for college students; this class increases awareness and understanding of landscape architecture as a profession. Though this is a wonderful resource offered at the college level, high school is a key time for career awareness. Unfortunately, there is a lack of student awareness surrounding the profession of landscape architecture. In Utah and the rest of the United States, there are currently no in-person Introduction to Landscape Architecture classes available in a high school setting to increase awareness and understanding for students in a high school setting. Providing a …
Bizindan Miinawa (Listen Again), Matthew L.M. Fletcher
Bizindan Miinawa (Listen Again), Matthew L.M. Fletcher
Articles
Johnson v. McIntosh was as fake as John Wayne’s teeth. That one was a property dispute, remember? Two wealthy, privileged, and powerful white people squared off over thousands of acres of land acquired from Indigenous nations who called the vast valley of Eagle River home. On one side, you had a former United States Supreme Court Justice; on the other, you had a wealthy political benefactor/beneficiary. No tribal nations or Indigenous peoples to be seen or heard from. And of course, the competing property claims at issue barely overlapped, if at all, thanks to stipulations of the parties at the …
Sexual Assault Victims Face A Penalty For Adjacent Consent, Jillian J. Jordan, Roseanna Sommers
Sexual Assault Victims Face A Penalty For Adjacent Consent, Jillian J. Jordan, Roseanna Sommers
Articles
Sexual assault is pervasively underreported, and victims are often blamed and stigmatized. We highlight an important but overlooked factor that may contribute to these outcomes: adjacent consent. Even when a rape is objected to verbally and physically, and accomplished only through violent force, respondents see the victim as less virtuous and deserving of support if she previously consented to something sexual with her perpetrator (e.g., kissing, foreplay, sex on a prior occasion). Our findings are striking in an age of “no means no” and “affirmative consent”—and notably hold among even young and politically progressive respondents who do not otherwise disapprove …
The T2-Flair Mismatch Sign In Oncologic Neuroradiology: History, Current Use, Emerging Data, And Future Directions, Samir A Dagher, Riley Hideo Lochner, Burak Berksu Ozkara, Donald F Schomer, Max Wintermark, F Eymen Ucisik
The T2-Flair Mismatch Sign In Oncologic Neuroradiology: History, Current Use, Emerging Data, And Future Directions, Samir A Dagher, Riley Hideo Lochner, Burak Berksu Ozkara, Donald F Schomer, Max Wintermark, F Eymen Ucisik
Faculty, Staff and Student Publications
The T2-Fluid-Attenuated Inversion Recovery (T2-FLAIR) mismatch sign is a radiogenomic marker that is easily discernible on preoperative conventional MR imaging. Application of strict criteria (adult population, cerebral hemisphere location, and classic imaging morphology) permits the noninvasive preoperative diagnosis of isocitrate dehydrogenase (IDH)-mutant 1p/19q-non-codeleted diffuse astrocytoma with near-perfect specificity, albeit with variably low sensitivity. This leads to improved preoperative planning and patient counseling. More recent research has shown that the application of less strict criteria compromises the near-perfect specificity of the sign but remains adequate for ruling out IDH-wildtype (glioblastoma) phenotype, which bears a far grimmer prognosis compared to IDH-mutant diffuse …
Poly(Adp-Ribose) Polymerase-1 Regulates Pyroptosis Independent Function Of Nlrp3 Inflammasome In Neutrophil Extracellular Trap Formation, Louis J Delinois, Atul Sharma, Ashwin K Ramesh, Laurel D Boatright, Qun Li, Hongbo R Luo, Jyotika Sharma
Poly(Adp-Ribose) Polymerase-1 Regulates Pyroptosis Independent Function Of Nlrp3 Inflammasome In Neutrophil Extracellular Trap Formation, Louis J Delinois, Atul Sharma, Ashwin K Ramesh, Laurel D Boatright, Qun Li, Hongbo R Luo, Jyotika Sharma
Faculty, Staff and Student Publications
Neutrophil extracellular traps (NETs) function to control infectious agents as well as to propagate inflammatory response in a variety of disease conditions. DNA damage associated with chromatin decondensation and NACHT domain-leucine-rich repeat-and pyrin domain-containing protein 3 (NLRP3) inflammasome activation have emerged as crucial events in NET formation, but the link between the two processes is unknown. In this study, we demonstrate that poly(ADP-ribose) polymerase-1 (PARP-1), a key DNA repair enzyme, regulates NET formation triggered by NLRP3 inflammasome activation in neutrophils. Activation of mouse neutrophils with canonical NLRP3 stimulants LPS and nigericin induced NET formation, which was significantly abrogated by pharmacological …
Pbi-05204, A Supercritical Co2 Extract Of Nerium Oleander, Suppresses Glioblastoma Stem Cells By Inhibiting Grp78 And Inducing Programmed Necroptotic Cell, Sharmistha Chakraborty, Daoyan Wei, Megan Tran, Frederick F Lang, Robert A Newman
Pbi-05204, A Supercritical Co2 Extract Of Nerium Oleander, Suppresses Glioblastoma Stem Cells By Inhibiting Grp78 And Inducing Programmed Necroptotic Cell, Sharmistha Chakraborty, Daoyan Wei, Megan Tran, Frederick F Lang, Robert A Newman
Faculty, Staff and Student Publications
Successful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs) and the underlying mechanisms. Treatment with PBI-05204 significantly reduced both the number and size of tumor spheres derived from patient-derived GSCs (GBM9, GSC28 and TS543), and suppressed the tumorigenesis of GBM9 xenografts. Moreover, PBI-05204 treatment led to a significant decrease in the expression of CD44 and NANOG, crucial markers of progenitor stem cells, in GBM9 and GSC28 GSCs. This treatment also down-regulated GRP78 expression …
Mapping The Single-Cell Differentiation Landscape Of Osteosarcoma, Danh D Truong, Corey Weistuch, Kevin A Murgas, Prasad Admane, Bridgette L King, Salah-E Lamhamedi-Cherradi, Najat C Daw, Nancy Gordon, Vidya Gopalakrishnan, Richard G Gorlick, Neeta Somaiah, Joseph O Deasy, Antonios G Mikos, Allen Tannenbaum, Joseph Ludwig
Mapping The Single-Cell Differentiation Landscape Of Osteosarcoma, Danh D Truong, Corey Weistuch, Kevin A Murgas, Prasad Admane, Bridgette L King, Salah-E Lamhamedi-Cherradi, Najat C Daw, Nancy Gordon, Vidya Gopalakrishnan, Richard G Gorlick, Neeta Somaiah, Joseph O Deasy, Antonios G Mikos, Allen Tannenbaum, Joseph Ludwig
Faculty, Staff and Student Publications
Purpose: The genetic intratumoral heterogeneity observed in human osteosarcomas poses challenges for drug development and the study of cell fate, plasticity, and differentiation, which are processes linked to tumor grade, cell metastasis, and survival.
Experimental design: To pinpoint errors in osteosarcoma differentiation, we transcriptionally profiled 31,527 cells from a tissue-engineered model that directs mesenchymal stem cells toward adipogenic and osteoblastic fates. Incorporating preexisting chondrocyte data, we applied trajectory analysis and non-negative matrix factorization to generate the first human mesenchymal differentiation atlas.
Results: This "roadmap" served as a reference to delineate the cellular composition of morphologically complex osteosarcoma tumors and quantify …
Tumoral Interferon Beta Induces An Immune-Stimulatory Phenotype In Tumor-Associated Macrophages In Melanoma Brain Metastases, Julia Gellert, Dennis A Agardy, Swaminathan Kumar, Alexandros Kourtesakis, Tamara Boschert, Michael O Breckwoldt, Wolfgang Wick, Michael A Davies, Michael Platten, Theresa Bunse
Tumoral Interferon Beta Induces An Immune-Stimulatory Phenotype In Tumor-Associated Macrophages In Melanoma Brain Metastases, Julia Gellert, Dennis A Agardy, Swaminathan Kumar, Alexandros Kourtesakis, Tamara Boschert, Michael O Breckwoldt, Wolfgang Wick, Michael A Davies, Michael Platten, Theresa Bunse
Faculty, Staff and Student Publications
Type I interferons (IFN) are immune-stimulatory cytokines involved in antiviral and antitumor immune responses. They enhance the efficacy of immunogenic anticancer therapies such as radiotherapy by activating both innate and adaptive immune cells. Macrophages are one of the most abundant innate immune cells in the immune microenvironment of melanoma brain metastases (MBM) and can exert potent immune-suppressive functions. Here, we investigate the potential of tumoral type I IFNs to repolarize tumor-associated macrophages (TAM) in two murine MBM models and assess the effects of radiotherapy-induced type I IFN on TAMs in a transcriptomic MBM patient dataset. In mice, we describe a …
Nf1 Mutation Disrupts Activity-Dependent Oligodendroglial Plasticity And Motor Learning In Mice, Yuan Pan, Jared D Hysinger, Belgin Yalçın, James J Lennon, Youkyeong Gloria Byun, Nicole F Schindler, Jit Chatterjee, Lijun Ni, Haojun Xu, Karen Malacon, Samin M Jahan, Alexis E Ivec, Benjamin E Aghoghovwia, Christopher W Mount, Surya Nagaraja, Suzanne Scheaffer, Laura D Attardi, David H Gutmann, Michelle Monje
Nf1 Mutation Disrupts Activity-Dependent Oligodendroglial Plasticity And Motor Learning In Mice, Yuan Pan, Jared D Hysinger, Belgin Yalçın, James J Lennon, Youkyeong Gloria Byun, Nicole F Schindler, Jit Chatterjee, Lijun Ni, Haojun Xu, Karen Malacon, Samin M Jahan, Alexis E Ivec, Benjamin E Aghoghovwia, Christopher W Mount, Surya Nagaraja, Suzanne Scheaffer, Laura D Attardi, David H Gutmann, Michelle Monje
Faculty, Staff and Student Publications
Neurogenetic disorders, such as neurofibromatosis type 1 (NF1), can cause cognitive and motor impairments, traditionally attributed to intrinsic neuronal defects such as disruption of synaptic function. Activity-regulated oligodendroglial plasticity also contributes to cognitive and motor functions by tuning neural circuit dynamics. However, the relevance of oligodendroglial plasticity to neurological dysfunction in NF1 is unclear. Here we explore the contribution of oligodendrocyte progenitor cells (OPCs) to pathological features of the NF1 syndrome in mice. Both male and female littermates (4-24 weeks of age) were used equally in this study. We demonstrate that mice with global or OPC-specific Nf1 heterozygosity exhibit defects …
Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk For Breast Cancer, Xiaohui Sun, Shiv P Verma, Guochong Jia, Xinjun Wang, Jie Ping, Xiao-Ou Shu, Andriy Derkach, Qiuyin Cai, Xiaolin Liang, Jirong Long, Kenneth Offit, Jung H Oh, Anne S Reiner, Gordon P Watt, Meghan Woods, Yaohua Yang, Christine B Ambrosone, Stefan Ambs, Yu Chen, Patrick Concannon, Montserrat Garcia-Closas, Jian Gu, Christopher A Haiman, Jennifer J Hu, Dezheng Huo, Esther M John, Julia A Knight, Christopher I Li, Charles F Lynch, Lene Mellemkjær, Katherine L Nathanson, Barbara Nemesure, Olufunmilayo I Olopade, Andrew F Olshan, Tuya Pal, Julie R Palmer, Michael F Press, Maureen Sanderson, Dale P Sandler, Melissa A Troester, Wei Zheng, Jonine L Bernstein, Matthew F Buas, Xiang Shu
Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk For Breast Cancer, Xiaohui Sun, Shiv P Verma, Guochong Jia, Xinjun Wang, Jie Ping, Xiao-Ou Shu, Andriy Derkach, Qiuyin Cai, Xiaolin Liang, Jirong Long, Kenneth Offit, Jung H Oh, Anne S Reiner, Gordon P Watt, Meghan Woods, Yaohua Yang, Christine B Ambrosone, Stefan Ambs, Yu Chen, Patrick Concannon, Montserrat Garcia-Closas, Jian Gu, Christopher A Haiman, Jennifer J Hu, Dezheng Huo, Esther M John, Julia A Knight, Christopher I Li, Charles F Lynch, Lene Mellemkjær, Katherine L Nathanson, Barbara Nemesure, Olufunmilayo I Olopade, Andrew F Olshan, Tuya Pal, Julie R Palmer, Michael F Press, Maureen Sanderson, Dale P Sandler, Melissa A Troester, Wei Zheng, Jonine L Bernstein, Matthew F Buas, Xiang Shu
Faculty, Staff and Student Publications
Breast cancer includes several subtypes with distinct characteristic biological, pathologic, and clinical features. Elucidating subtype-specific genetic etiology could provide insights into the heterogeneity of breast cancer to facilitate the development of improved prevention and treatment approaches. In this study, we conducted pairwise case-case comparisons among five breast cancer subtypes by applying a case-case genome-wide association study (CC-GWAS) approach to summary statistics data of the Breast Cancer Association Consortium. The approach identified 13 statistically significant loci and eight suggestive loci, the majority of which were identified from comparisons between triple-negative breast cancer (TNBC) and luminal A breast cancer. Associations of lead …
Cluster-Based Toxicity Estimation Of Osteoradionecrosis Via Unsupervised Machine Learning: Moving Beyond Single Dose-Parameter Normal Tissue Complication Probability By Using Whole Dose-Volume Histograms For Cohort Risk Stratification, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Cem Dede, Travis C Salzillo, Lisanne V Van Dijk, Stephen Y Lai, Clifton D Fuller
Cluster-Based Toxicity Estimation Of Osteoradionecrosis Via Unsupervised Machine Learning: Moving Beyond Single Dose-Parameter Normal Tissue Complication Probability By Using Whole Dose-Volume Histograms For Cohort Risk Stratification, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Cem Dede, Travis C Salzillo, Lisanne V Van Dijk, Stephen Y Lai, Clifton D Fuller
Faculty, Staff and Student Publications
PURPOSE: Given the limitations of extant models for normal tissue complication probability estimation for osteoradionecrosis (ORN) of the mandible, the purpose of this study was to enrich statistical inference by exploiting structural properties of data and provide a clinically reliable model for ORN risk evaluation through an unsupervised-learning analysis that incorporates the whole radiation dose distribution on the mandible.
METHODS AND MATERIALS: The analysis was conducted on retrospective data of 1259 patients with head and neck cancer treated at The University of Texas MD Anderson Cancer Center between 2005 and 2015. During a minimum 12-month posttherapy follow-up period, 173 patients …
A Biallelic Variant Of The Rna Exosome Gene, Exosc4, Associated With Neurodevelopmental Defects Impairs Rna Exosome Function And Translation, Milo B Fasken, Sara W Leung, Lauryn A Cureton, Maha Al-Awadi, Adila Al-Kindy, Sohail Khoshnevis, Almundher Al-Maawali, Anita H Corbett
A Biallelic Variant Of The Rna Exosome Gene, Exosc4, Associated With Neurodevelopmental Defects Impairs Rna Exosome Function And Translation, Milo B Fasken, Sara W Leung, Lauryn A Cureton, Maha Al-Awadi, Adila Al-Kindy, Sohail Khoshnevis, Almundher Al-Maawali, Anita H Corbett
Faculty, Staff and Student Publications
The RNA exosome is an evolutionarily conserved complex required for both precise RNA processing and decay. Pathogenic variants in EXOSC genes, which encode structural subunits of this complex, are linked to several autosomal recessive disorders. Here, we describe a missense allele of the EXOSC4 gene that causes a collection of clinical features in two affected siblings. This missense variant (NM_019037.3: exon3:c.560T>C) changes a leucine residue within a conserved region of EXOSC4 to proline (p.Leu187Pro). The two affected individuals show prenatal growth restriction, failure to thrive, global developmental delay, intracerebral and basal ganglia calcifications, and kidney failure. Homozygosity for the …
T-Cell-Rich Hodgkin Lymphoma With Features Of Classic Hodgkin Lymphoma And Nodular Lymphocyte-Predominant Hodgkin Lymphoma: A Borderline Category With Overlapping Morphologic And Immunophenotypic Features, Siba El Hussein, Hong Fang, Fatima Zahra Jelloul, Wei Wang, Sanam Loghavi, Jonathan W Friedberg, Andrew G Evans, Jie Xu, L Jeffrey Medeiros
T-Cell-Rich Hodgkin Lymphoma With Features Of Classic Hodgkin Lymphoma And Nodular Lymphocyte-Predominant Hodgkin Lymphoma: A Borderline Category With Overlapping Morphologic And Immunophenotypic Features, Siba El Hussein, Hong Fang, Fatima Zahra Jelloul, Wei Wang, Sanam Loghavi, Jonathan W Friedberg, Andrew G Evans, Jie Xu, L Jeffrey Medeiros
Faculty, Staff and Student Publications
Context.—: It is known that a subset of cases of classic Hodgkin lymphoma (CHL) with B-cell-rich nodules (lymphocyte-rich CHL) exhibits morphologic and immunophenotypic features that overlap with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), raising diagnostic difficulties that can be resolved in most cases by performing an adequate battery of immunohistochemical studies.
Objective.—: To fully characterize cases of T-cell-rich Hodgkin lymphoma where a specific diagnosis of NLPHL (ie, pattern D) or CHL could not be made even after complete immunophenotypic investigation.
Design.—: The clinical, immunomorphologic, and molecular (when applicable) presentation of 3 cases of T-cell-rich Hodgkin lymphoma was thoroughly investigated.
Results.—: These …
Disparities In Exposure To Tobacco On Television Or Streaming Platforms, Henry K Onyeaka, Onyema G Chido-Amajuoyi, Itunu Sokale, Kobi V Ajayi, A Eden Evins, Sanjay Shete
Disparities In Exposure To Tobacco On Television Or Streaming Platforms, Henry K Onyeaka, Onyema G Chido-Amajuoyi, Itunu Sokale, Kobi V Ajayi, A Eden Evins, Sanjay Shete
Faculty, Staff and Student Publications
Importance: With the rise in popularity of streaming platforms concerns about exposure to tobacco advertising and promotion have emerged. While tobacco marketing and promotion through traditional television (TV) media channels has been extensively studied, less is known about exposure to tobacco through TV or streaming platforms and its associated factors.
Objective: To examine the prevalence and factors associated with exposure to tobacco products advertised, marketed, or promoted on TV or streaming platforms among US adults.
Design, setting, and participants: This cross-sectional study used data from the National Cancer Institute's Health Information National Trends Survey (HINTS 6), conducted from March 7 …