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Paediatric Strategy Forum For Medicinal Product Development Of Pi3-K, Mtor, Akt And Gsk3Β Inhibitors In Children And Adolescents With Cancer, Andrew Dj Pearson, Steven G Dubois, Margaret E Macy, Teresa De Rojas, Martha Donoghue, Susan Weiner, Holly Knoderer, Ronald Bernardi, Vickie Buenger, Guillaume Canaud, Lewis Cantley, John Chung, Elizabeth Fox, John Friend, Julia Glade-Bender, Igor Gorbatchevsky, Lia Gore, Abha Gupta, Douglas S Hawkins, Dejan Juric, Leigh Anna Lang, Danielle Leach, Danny Liaw, Giovanni Lesa, Franca Ligas, Gavin Lindberg, Wendy Lindberg, Donna Ludwinski, Lynley Marshall, Andrew Mazar, Joe Mcdonough, Karsten Nysom, Christopher Ours, Alberto Pappo, D William Parsons, Amy Rosenfeld, Nicole Scobie, Malcolm Smith, Danielle Taylor, Brenda Weigel, Amy Weinstein, Dominik Karres, Gilles Vassal Aug 2024

Paediatric Strategy Forum For Medicinal Product Development Of Pi3-K, Mtor, Akt And Gsk3Β Inhibitors In Children And Adolescents With Cancer, Andrew Dj Pearson, Steven G Dubois, Margaret E Macy, Teresa De Rojas, Martha Donoghue, Susan Weiner, Holly Knoderer, Ronald Bernardi, Vickie Buenger, Guillaume Canaud, Lewis Cantley, John Chung, Elizabeth Fox, John Friend, Julia Glade-Bender, Igor Gorbatchevsky, Lia Gore, Abha Gupta, Douglas S Hawkins, Dejan Juric, Leigh Anna Lang, Danielle Leach, Danny Liaw, Giovanni Lesa, Franca Ligas, Gavin Lindberg, Wendy Lindberg, Donna Ludwinski, Lynley Marshall, Andrew Mazar, Joe Mcdonough, Karsten Nysom, Christopher Ours, Alberto Pappo, D William Parsons, Amy Rosenfeld, Nicole Scobie, Malcolm Smith, Danielle Taylor, Brenda Weigel, Amy Weinstein, Dominik Karres, Gilles Vassal

Faculty, Staff and Students Publications

Phosphatidylinositol 3-kinase (PI3-K) signalling pathway is a crucial path in cancer for cell survival and thus represents an intriguing target for new paediatric anti-cancer drugs. However, the unique clinical toxicities of targeting this pathway (resulting in hyperglycaemia) difficulties combining with chemotherapy, rarity of mutations in childhood tumours and concomitant mutations have resulted in major barriers to clinical translation of these inhibitors in treating both adults and children. Mutations in PIK3CA predict response to PI3-K inhibitors in adult cancers. The same mutations occur in children as in adults, but they are significantly less frequent in paediatrics. In children, high-grade gliomas, especially …

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Informed Consent Document Delivery: Effects On Appalachian Caregivers' Comprehension, Trust In Researchers, And Willingness To Participate, Tess A. Simpson Aug 2024

Informed Consent Document Delivery: Effects On Appalachian Caregivers' Comprehension, Trust In Researchers, And Willingness To Participate, Tess A. Simpson

Electronic Theses and Dissertations

The purpose of the present study was to investigate whether altering an informed consent document (ICD), in ways that either promote or inhibit accessibility, would affect potential participants’ willingness to participate in a child development laboratory-based study. Specifically, I was interested in assessing the willingness to participate of historically underrepresented groups, especially Appalachian caregiver-child dyads. I altered three parameters of a previously approved and employed ICD to explore whether these parameters impacted Appalachian caregivers’ comprehension of the study, willingness to participate, and trust in the researchers. The manipulated parameters included reading level, utilization of illustrative pictures, and inclusion of text-to-speech …

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Pilz Domain-Containing Proteins Regulate Motility In Acinetobacter Baumannii, Gabriel Smith Aug 2024

Pilz Domain-Containing Proteins Regulate Motility In Acinetobacter Baumannii, Gabriel Smith

Electronic Theses and Dissertations

Acinetobacter baumannii is an increasingly multidrug-resistant pathogen contributing to hospital-acquired infections, necessitating a greater understanding of how it interacts with its surroundings. Many bacteria utilize different methods of bacterial motility to move about and interact with these surroundings. A bacterial second messenger, cyclic diguanosine monophosphate (c-di-GMP), can regulate various motility factors that are potentially advantageous for survival in and adaptation to their environment. Concentrations of c-di-GMP are regulated by specific synthesizing and degrading enzymes. Controlled levels of c-di-GMP allow interaction between the c-di-GMP and its binding effectors that induce changes in bacterial phenotypes such as biofilm formation and motility. A …

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Linking Physiology, Epidemiology, And Demography: Understanding How Lianas Outcompete Trees In A Changing World, Hannes De Deurwaerder, Matteo Detto, Marco Visser, Stefan A. Schnitzer, Stephen W. Pacala Aug 2024

Linking Physiology, Epidemiology, And Demography: Understanding How Lianas Outcompete Trees In A Changing World, Hannes De Deurwaerder, Matteo Detto, Marco Visser, Stefan A. Schnitzer, Stephen W. Pacala

Biological Sciences Faculty Research and Publications

Extending and safeguarding tropical forest ecosystems is critical for combating climate change and biodiversity loss. One of its constituents, lianas, is spreading and increasing in abundance on a global scale. This is particularly concerning as lianas negatively impact forests’ carbon fluxes, dynamics, and overall resilience, potentially exacerbating both crises. While possibly linked to climate-change-induced atmospheric CO2 elevation and drought intensification, the reasons behind their increasing abundance remain elusive. Prior research shows distinct physiological differences between lianas and trees, but it is unclear whether these differences confer a demographic advantage to lianas with climate change. Guided by extensive datasets collected …

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Of Cells And Tissues: Identifying The Elements Of A Diabetic Cardiac In Vitro Study Model, Ivana Hernandez Aug 2024

Of Cells And Tissues: Identifying The Elements Of A Diabetic Cardiac In Vitro Study Model, Ivana Hernandez

Open Access Theses & Dissertations

This study aimed to elucidate the impact of advanced glycation end products (AGEs) and glucose shock on cardiomyocyte viability, gene expression, cardiac biomarkers, and cardiac contractility. Firstly, AGEs were generated in-house, and their concentration was confirmed using absorbance measurements. AC16 cardiomyocytes were then exposed to varying doses of AGEs, resulting in dose-dependent decreases in cell viability. The maximum tolerated dose of AGEs was determined, revealing significant downregulation of the cardiac gene gap junction alpha 1 (GJA1). Furthermore, the study assessed the effects of AGEs, glucose shock, and their combination on biomarkers, cardiac myosin heavy chain (MHC), and connexin-43 (Cx-43) in …

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Neural Networks For Decisions Under Uncertainty, Edwin Tomy George Aug 2024

Neural Networks For Decisions Under Uncertainty, Edwin Tomy George

Open Access Theses & Dissertations

Neural networks are used in many real-world applications, ranging from classification tasks to medical diagnostics. For each task, a neural network is typically able to make predictions due to its ability to extract meaningful patterns from processing large amounts of data. Thus, given the increases in available data in recent decades, the performance of neural networks in making accurate predictions has greatly increased. However, this data often comes with ingrained uncertainties due to measurement errors or the inherent variability of individual data points. Neural networks can learn despite the errors in the overall data, but what if we want them …

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Border Soundscapes: Latinidad, Belonging, And Sense Of Place In The Paso Del Norte Region., Josã© Manuel Flores Fuentes Aug 2024

Border Soundscapes: Latinidad, Belonging, And Sense Of Place In The Paso Del Norte Region., Josã© Manuel Flores Fuentes

Open Access Theses & Dissertations

This dissertation explores the acoustic ecologies of the Juárez-El Paso border, investigating how soundscapes shape and reflect the cultural identity, sense of belonging, and sense of place within this unique transnational region. Guided by the theoretical lenses of belonging (Kohut, Tajfel, Turner, Hooks), sense of place (Feld & Basso), and habitus (Bourdieu), the research takes a phenomenological approach, informed by Merleau-Ponty's concepts of perception and Ceraso's notion of embodied listening. The study analyzes soundscape samples through Krause's categories of biophonies, geophonies, and anthropophonies, uncovering how these sounds contribute to the development of Latino identity and cultural cohesion in the borderlands.Focusing …

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The Riddle Of Religious Language, Luke Hillman Aug 2024

The Riddle Of Religious Language, Luke Hillman

Graduate Theses and Dissertations

The following project analyzes religious life through the lens of religious language. Motivated by ideas of Wittgenstein and Wittgensteinians, religious language is shown to be nonsensical, and yet significant. Wittgenstein connects how we understand language with how we understand life, and this connection extends to religious life. This project offers an answer to how religious language is unique by comparing religious language to riddles and the process of answering riddles. In addition, religious language becomes understandable with imagination, a relationship with the transcendent, and an understanding of the kinds of language present in religious discourse. These ideas are solidified with …

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The Impact Of Algorithmic Control And Algorithmic Management In Online Labor Platforms, Yaping Zhu Aug 2024

The Impact Of Algorithmic Control And Algorithmic Management In Online Labor Platforms, Yaping Zhu

Graduate Theses and Dissertations

Online labor platforms (OLPs) are transforming the way organizations operate and how people work. Platform work has been characterized as promoting autonomy and flexibility. Workers interact with a platform rather than human managers to accomplish tasks and they have the freedom to decide when, where, and how much to work. Yet, platform workers increasingly bemoan working conditions, revealing that the expected autonomy and flexibility benefits of platform work have not materialized. Current IS research sheds light on this phenomenon by explaining that platform organizations use algorithms to manage and control workers (i.e., algorithmic control). Yet, our understanding of how algorithmic …

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A Mixed Methods Study Exploring The Impact Of Embedded Trauma-Informed Practices On Academic-Related Behaviors Of Students Who Have Experienced Trauma And The Relationship Between Trauma-Informed Practices And Student Benchmark Growth Data, Sarah Isaac Aug 2024

A Mixed Methods Study Exploring The Impact Of Embedded Trauma-Informed Practices On Academic-Related Behaviors Of Students Who Have Experienced Trauma And The Relationship Between Trauma-Informed Practices And Student Benchmark Growth Data, Sarah Isaac

Graduate Theses and Dissertations

This mixed methods study examined the relationship between school-based embedded trauma-informed practices and academic-related outcomes for students. While there is minimal empirical evidence supporting the impact of trauma-informed practices on the academic success of students who have experienced trauma, there is some qualitative, quantitative, and anecdotal data supporting outcomes stemming from trauma-informed practices in the research. The research questions guiding this study were (1) What impact does the implementation of embedded trauma-informed practices have on the academic-related behaviors of students who have experienced trauma? and (2) What is the relationship between benchmark growth scores for students with an ACE score …

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Rural-Urban Migration And The Extent Of Urbanization: A Case Study Of Rural Migrants From Northern Ghana To Accra, Daniel Kissi-Somuah Aug 2024

Rural-Urban Migration And The Extent Of Urbanization: A Case Study Of Rural Migrants From Northern Ghana To Accra, Daniel Kissi-Somuah

Graduate Theses and Dissertations

This study delves into the dynamics of rural-to-urban migration, emphasizing its impact on urbanization in the unique context of Ghana. As migration patterns evolve globally, understanding the motivations and challenges of internal migration is crucial for informed policy-making. The case study focuses on migrants from Northern Ghana to Accra, exploring factors propelling urbanization, challenges in urban job searches, and proposing strategies for managing urbanization. The research uses a comprehensive methodology to draw on extensive data from the 2021 Population and Housing Census. Utilizing thematic reports on migration, economic activities, background characteristics, and education, the study employs descriptive and inferential statistical …

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Molecular Beam Epitaxy Of Gesn On Iii-V Substrates For Photonic Applications, Calbi Gunder Aug 2024

Molecular Beam Epitaxy Of Gesn On Iii-V Substrates For Photonic Applications, Calbi Gunder

Graduate Theses and Dissertations

This dissertation explores the advancement of germanium-tin (GeSn) as a tuneable narrow bandgap material, crucial for the development of high-efficiency photodetectors and laser devices in near- and mid-infrared technologies. We investigate the synthesis challenges, particularly the lattice mismatch between GeSn alloys and substrates, which significantly affects their crystalline and optical qualities. Through molecular beam epitaxy, we examine the growth of Ge and GeSn on GaAs (001) substrates, employing Ge/GaAs and Ge/AlAs buffer layers to investigate these challenges. Our findings, characterized by X-ray diffraction, atomic force microscopy, reflection high-energy electron diffraction, and photoluminescence, demonstrate the production of high-quality Ge layers, achieving …

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“Wa Ya See?”: An Autoethnographic Exploration Of The Nuanced Experiences Of A Black, Quare, Afro-Caribbean, Asylum Seeker In The United States Higher Education., Travis A. Richards Aug 2024

“Wa Ya See?”: An Autoethnographic Exploration Of The Nuanced Experiences Of A Black, Quare, Afro-Caribbean, Asylum Seeker In The United States Higher Education., Travis A. Richards

LMU Theses and Dissertations

In the 2022-2023 academic year, nearly one million international students from over 200 countries enrolled in U.S. higher education institutions, marking a 12% increase from the previous year (Martel & Baer, 2022). Despite representing 5.6% of the total U.S. higher education population, asylum-seeking students remained an overlooked demographic, underscoring the challenges faced by marginalized groups within academia (Buchholz, 2023). This research focused on the experience of a Black, Quare, Afro-Caribbean, asylum-seeking doctoral student, employing autoethnographic methods to examine the complex intersections of race, sexuality, and transnational identity. Grounded in Intersectionality Theory (Crenshaw, 1991), Critical Race Theory (Bell, 1995), Quare Theory …

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A Case For Increasing Taxes On Cigarettes, Vapes And Oral Nicotine Pouches, Ken, Cyprian Mostert, Olalekan Ayo-Yusuf, Manasi Kumar, Andrew Aballa, Willie Njoroge, Edna Bosire, Linda Khakali, John Thomi, Lukoye Atwoli, Zul Merali Aug 2024

A Case For Increasing Taxes On Cigarettes, Vapes And Oral Nicotine Pouches, Ken, Cyprian Mostert, Olalekan Ayo-Yusuf, Manasi Kumar, Andrew Aballa, Willie Njoroge, Edna Bosire, Linda Khakali, John Thomi, Lukoye Atwoli, Zul Merali

Population Health, East Africa

No abstract provided.

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Fostering Students’ Development Of Productive Representation Systems For Infinite Series, Derek Eckman, Kyeong Hah Roh Aug 2024

Fostering Students’ Development Of Productive Representation Systems For Infinite Series, Derek Eckman, Kyeong Hah Roh

The Mathematics Enthusiast

Students’ development of reasoning through algebraic symbols is a crucial component of most mathematics courses. This paper reports the journey of one second-semester calculus student, Cedric, as he attempted to reason about and create algebraic representations for arbitrary partial sums and infinite series through two exploratory teaching interviews. We report Cedric’s symbolizing activity in terms of Eckman's (2023) expression framework, focusing on Cedric’s development and attribution of meaning to a personal expression template for denoting partial sums and series. Specifically, we describe how Cedric leveraged his initial meanings for partial sums to create personal expressions to reason about infinite series. …

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(Don’T Fear) The Factors: An Item-Level Meta-Analysis Of The Fear Of Covid-19 Scale’S Factor Structure And Measurement Invariance, William P. Jimenez, Asiye Zeytonli, Yasmine Nabulsi, Xiaoxiao Hu Aug 2024

(Don’T Fear) The Factors: An Item-Level Meta-Analysis Of The Fear Of Covid-19 Scale’S Factor Structure And Measurement Invariance, William P. Jimenez, Asiye Zeytonli, Yasmine Nabulsi, Xiaoxiao Hu

Psychology Faculty Publications

The global COVID-19 pandemic saw marked research and clinical interest in evaluating pandemic-related distress, namely fear and anxiety regarding infection and death. The most widely used and earliest developed measure of COVID-19 distress is Ahorsu et al. (2022) seven-item Fear of COVID-19 Scale (FCV-19S). To investigate the factor structure and measurement equivalence of the FCV-19S, we conducted an item-level meta-analysis synthesizing 1155 effect sizes across k = 55 independent samples comprising N = 71,161 individuals. We found that a two-factor measurement model comprising a four-item Emotional factor and a three-item Psychosomatic factor exhibits better fit than the originally proposed single-factor …

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Differential Behavior Of Conformational Dynamics In Active And Inactive States Of Cannabinoid Receptor 1, Ugochi H. Isu, Adithya Polasa, Mahmoud Moradi Aug 2024

Differential Behavior Of Conformational Dynamics In Active And Inactive States Of Cannabinoid Receptor 1, Ugochi H. Isu, Adithya Polasa, Mahmoud Moradi

Chemistry & Biochemistry Faculty Publications and Presentations

Cannabinoid receptor 1 (CB1) is a G protein-coupled receptor that regulates critical physiological processes including pain, appetite, and cognition. Understanding the conformational dynamics of CB1 associated with transitions between inactive and active signaling states is imperative for developing targeted modulators. Using microsecond-level all-atom molecular dynamics simulations, we identified marked differences in the conformational ensembles of inactive and active CB1 in apo. The inactive state exhibited substantially increased structural heterogeneity and plasticity compared to the more rigidified active state in the absence of stabilizing ligands. Transmembrane helices TM3 and TM7 were identified as distinguishing factors modulating the state-dependent dynamics. TM7 …

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A New Look At Russia-China Relations: Implications, Expectations And Reality, Aidana Bolat Aug 2024

A New Look At Russia-China Relations: Implications, Expectations And Reality, Aidana Bolat

Dartmouth College Master’s Theses

This thesis examines the nature of the evolving relationship between Russia and China from 2018 to 2024, focusing on political, economic, and security aspects. The research aims to determine whether their interactions are an alliance, a partnership, or a more complex arrangement. The study takes a multidimensional approach: analyzing political cooperation through their participation in international organizations such as the UN, SCO, and BRICS, mutual support in UN voting records, diplomatic commitments, and regional political strategies. Economic cooperation is assessed through trade dynamics and analysis of official trade data. Security cooperation is examined by examining arms sales, joint military exercises, …

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The Impact Of Ectopic Expression Of A Plant Elicitor Peptide In Bacillus Subtilis On Nematode Resistance In Soybean Through Seed Treatment, Abeer Alnasrawi Aug 2024

The Impact Of Ectopic Expression Of A Plant Elicitor Peptide In Bacillus Subtilis On Nematode Resistance In Soybean Through Seed Treatment, Abeer Alnasrawi

Graduate Theses and Dissertations

Soybean (Glycine max) is the most beneficial legume crop because it is a source of protein as well as oil for humans and livestock. Soybean is the second most planted crop in the United States following corn and it is also the fourth planted crop worldwide. However, the soybean cyst nematode (Heterodera glycines, SCN) is the most damaging pest of soybean in the United States, accounting for more than twice as much yield loss as the following cause of yield loss in soybean. Therefore, there is a pressing need to develop alternative management strategies to control SCN infection in soybeans. …

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Harry Potter And The Immersive Space: A Rhetorical Analysis Of The Wizarding World Of Harry Potter, Kendra Bolin Aug 2024

Harry Potter And The Immersive Space: A Rhetorical Analysis Of The Wizarding World Of Harry Potter, Kendra Bolin

Electronic Theses and Dissertations

The ability of humans to share stories has changed over time. From myths shared around a campfire to the introduction of cinema, we can now tell massive, immersive stories on an epic scale. One example of this is the storytelling present in theme parks. Present-day theme parks are continuously growing and expanding each year both in size and attendance. The continued success of these theme parks and the rhetorical influences of their audiences is a cultural phenomenon that deserves rhetorical scrutiny. My analysis looks at how one theme park, the Wizarding World of Harry Potter in Orlando, Florida, immerses guests …

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Unraveling The Complex Dynamics Of Cardiac Fibrosis: Ccn1 As A Novel Regulator Of Scar Collagen Architecture And Structural Integrity In Myocardial Infarction., Annalara Garland Fischer Aug 2024

Unraveling The Complex Dynamics Of Cardiac Fibrosis: Ccn1 As A Novel Regulator Of Scar Collagen Architecture And Structural Integrity In Myocardial Infarction., Annalara Garland Fischer

Electronic Theses and Dissertations

Expansion of the extracellular matrix (ECM), known as fibrosis, accompanies nearly all forms of cardiac disease; however, its most significant and complex manifestations arise following a myocardial infarction (MI). This process, principally led by fibroblasts, constitutes a necessary and adaptive response acutely to fill the void from cardiomyocyte necrosis following ischemic injury due to the heart’s lack of regenerative capacity. This acute response never fully resolves and contributes to ongoing collagen accumulation in non-infarcted regions, leading to diminished ventricular compliance, ongoing myocyte loss, and attrition in function—culminating in heart failure. Further, recent research demonstrates that concomitant with progressive increases in …

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Exosomal Cannabidiol: A Promising Candidate For Targeted Oral Delivery Against Breast Cancer., Disha Nagesh Moholkar Aug 2024

Exosomal Cannabidiol: A Promising Candidate For Targeted Oral Delivery Against Breast Cancer., Disha Nagesh Moholkar

Electronic Theses and Dissertations

Cancer therapies are limited by lack of specificity, selectivity and numerous adverse effects. Repurposing potential anticancer compounds with appropriate drug carriers can help overcome these drawbacks. In our present study, we address the major obstacle for cannabidiol (CBD): its low oral bioavailability, using exosomes. Exosomes (Exo) are promising non-toxic and biocompatible drug delivery vehicles Our project aims are to address the research gap by formulating exosomal cannabidiol (ExoCBD): a tumor-targeted oral delivery system for the treatment of breast cancer. The targeting approach relies on the overexpression of folate receptors at the tumor site by using folic acid functionalized exosomes (FA-Exo). …

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What Is A Person? How Does One Become A Morally Good Person? The Intuitive View!, Tancredo Tivane Aug 2024

What Is A Person? How Does One Become A Morally Good Person? The Intuitive View!, Tancredo Tivane

Graduate Theses and Dissertations

This thesis centers around two philosophical problems: the concept of a person and the process by which one becomes a morally good person. Drawing on the works of philosophers such as Harry Frankfurt, Strawson, and A.J. Ayer, it begins with an inquiry into what it means to be a person. It argues that while humanhood, with its rational capacities, is a contingent rather than a necessary condition, it can serve as an accurate predictor of personhood. The thesis posits that personhood is an achievement rather than an inherent state, facilitated by interactions within a social framework that refine these rational …

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Moore’S Paradox, The First-Person, And Self-Knowledge, Matthew Warren Aug 2024

Moore’S Paradox, The First-Person, And Self-Knowledge, Matthew Warren

Graduate Theses and Dissertations

This thesis argues that Wittgenstein’s remarks on Moore’s paradox can be useful in resolving several debates concerning self-knowledge, particularly as that knowledge is manifested in avowals of belief, taking the form of sentences like “I believe that P”. Usually, sentences like these are taken to have a special first-person authority, epistemically privileged in comparison to their third-person counterparts ("He believes that P") and yet free from any reliance on evidence or observation in order to be made justifiably. It is also assumed that these avowals are functioning uniformly as reports on the speaker's mental state. Often, accounts of self-knowledge are …

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Table Of Contents - Cardozo Law Review, Volume 45, Issue 6 Aug 2024

Table Of Contents - Cardozo Law Review, Volume 45, Issue 6

Cardozo Law Review

No abstract provided.

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Bridging The Gap: Ai And The Hidden Structure Of Consciousness, Emily Barnes, James Hutson Aug 2024

Bridging The Gap: Ai And The Hidden Structure Of Consciousness, Emily Barnes, James Hutson

Faculty Scholarship

The quest to develop Artificial Intelligence (AI) systems that possess human-like consciousness necessitates a deep dive into both theoretical and practical aspects underpinning this ambitious goal. This article builds on initial philosophical explorations of AI consciousness by examining the intricate and often hidden structures that may facilitate conscious experiences in AI. Drawing from concepts in cognitive science and neuroscience, the article elucidates how AI systems can be designed to replicate the structural and functional aspects of human consciousness. The discussion includes the Hierarchy of Spatial Belongings proposed by Forti (2024), frameworks like the Integrated Information Theory (IIT), and models linking …

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Regrounding The Unworldly: Carnap’S Politically Engaged Logical Pluralism, Noah Friedman-Biglin Aug 2024

Regrounding The Unworldly: Carnap’S Politically Engaged Logical Pluralism, Noah Friedman-Biglin

Faculty Research, Scholarly, and Creative Activity

Recent discussions of logical pluralism trace its origins to Rudolf Carnap’s principle of tolerance; indeed, the principle is seen as one of Carnap’s lasting philosophical contributions. In this paper, I will argue that Carnap’s reasons for adopting this principle are not purely logical, but are rather founded in the Vienna Circle’s manifesto—a programmatic document that brings the Circle’s philosophical work together with a program of social change. Building on work by Uebel, Romizi, and others, I argue that we must understand the principle in light of Carnap’s role in writing the manifesto, and thus as integrated into the larger philosophical …

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Building Resilience To Contagious Diseases In High Contact Services: An Investigation Of Customers’ Willingness To Dine-In At Restaurants In The Era Of Covid, Hongli Ye Aug 2024

Building Resilience To Contagious Diseases In High Contact Services: An Investigation Of Customers’ Willingness To Dine-In At Restaurants In The Era Of Covid, Hongli Ye

All Dissertations

High customer contact services play a crucial role in our economy, providing essential interactions and experiences that drive numerous industries. However, the COVID-19 pandemic has posed significant challenges to these sectors due to their inherent characteristics, requiring close and frequent interactions. To rebound from the disruptions caused by such a contagious disease, service providers must adopt innovative strategies. Thus, this dissertation addresses the dynamic nature of building resilience strategies in high-contact services, which are affected by contagious diseases. In doing so, we propose an integrative framework that outlines essential new service resilience components, based on the CDC guidelines, to conventional …

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The Role Of Kinases Signaling In Organogenesis, Fatemeh Nasehi Aug 2024

The Role Of Kinases Signaling In Organogenesis, Fatemeh Nasehi

All Dissertations

Kinases are crucial regulators of organ development and differentiation. This thesis investi- gates the roles of TAK1, TGFbeta-Activate Kinase 1 (TAK1/Map3K7), and Akt3 kinases in skeletal, cardiac muscle, and cartilage. TAK1 is pivotal for the differentiation of various organ systems, including sinoatrial node and cartilage, and is responsible for phosphorylat- ing a diverse array of downstream kinases. We identified several novel proteins, including phospho-Akts, that are upregulated in response to TAK1 activation. We discovered severe Dilated Cardiomyopathy (DCM) and cartilage defects in Akt3 mutant mice. Although this mouse mutant has been studied for over two decades, we are the first …

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How Far Does The Apple Fall? Intergenerational Processes Underlying The Attainment Of Decent Work And Implications For Occupational Health And Well-Being, Baylor A. Graham Aug 2024

How Far Does The Apple Fall? Intergenerational Processes Underlying The Attainment Of Decent Work And Implications For Occupational Health And Well-Being, Baylor A. Graham

All Dissertations

Despite decades of progress spurred by the Decent Work Agenda (International Labor Organization, 1999), efforts to improve working conditions, ensure fair wages, and establish health and well-being as fundamental standards in employment practices continue to be sorely needed. The burden of inadequate decent work has demonstrated profound effects on individual health and well-being. However, the effects of inadequate decent work are rarely investigated over long periods of time and are entirely unexplored in relation to effects on children as they age and enter the workforce themselves. Accordingly, this dissertation investigated the intergenerational effects of decent work, extending beyond the immediate …

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