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Cellular And Molecular Basis Of Cd4+ T Cell Help At The Effector Phase During Immunotherapy Of Mhc-Ii Negative Tumors, Samuel Oche Ameh

Arts & Sciences Graduate Student Theses and Dissertations

Immune checkpoint therapies (ICT) have shown promise in treating solid tumors, providing cures and durable protection in some cases. However, only a subset of patients benefits from ICT, indicating a need for a deeper understanding of the requirements for successful therapy. In both mice and humans, αβ T cells are key mediators of spontaneous and ICT-induced anti-tumor responses. While the anti-tumor roles of CD8+ T cells are well-studied, the role of CD4+ T cells, particularly in ICT for MHC-II negative tumors, is less understood. New insights into how CD4+ T cells modulate CD8+ T cells during ICT may lead to …

Off The Guardrails: Opportunities And Caveats For Name Image Likeness And The [Student] Athlete Influencer, Maureen Weston

Texas A&M Law Review

The landscape of college athletics is undergoing a seismic shift with the advent of Name, Image, and Likeness (“NIL”) opportunities for student-athletes. In Off the Guardrails: Opportunities and Caveats for Name Image Likeness and the [Student] Athlete Influencer, Professor Maureen A. Weston examines the evolving terrain, tracing the journey from the National Collegiate Athletic Association’s (“NCAA’s”) rigid amateurism policies to the current era of NIL legislation and its implications. This Article navigates the complex intersection of athlete empowerment, entrepreneurial ventures, and regulatory challenges, shedding light on the multifaceted opportunities and risks for athletes in the burgeoning NIL market.

Delving …

Good Lawyers, Good Sports?: The Professional Identity Of Sports Lawyers Representing Not-For-Profit Entities, Bruce Green

Texas A&M Law Review

ABA accreditation standards require law schools to develop students’ professional identity, including by encouraging “an intentional exploration of” the legal profession’s “values [and] guiding principles.” This Essay invites legal academia as well as practitioners to explore issues of legal ethics, professionalism, and, especially, professional identity in the context of a new area of legal practice: sports lawyers’ representation of “NIL collectives,” which are not-forprofit entities that college boosters establish to enable college athletes to benefit financially from their name, image and likeness (“NIL”). The work of sports lawyers advising NIL collectives offers an interesting case study for considering how professional …

Constructing Death Worlds: Israel’S Occupation Of Palestine, Nichole S. Arel

Seton Hall University Dissertations and Theses (ETDs)

Achille Mbembe’s seminal work Necropolitics explains how the ultimate power of sovereignty is not exercised as Michel Foucault asserts in his theory of biopower in life over death, but rather in relegating certain populations to deathworlds, a place between the living and the dead. For over half of a century, Israel has illegally occupied both the West Bank and Gaza and exerted almost total control over the territories. It controls infrastructure such as roads, building permits, and water rights while also regulating the freedom of movement of Palestinians within and outside the West Bank's borders in addition to various other …

Matter Of Friedman V New York State Div. Of Hous. & Community Renewal

All Decisions

The tenants in a rent-stabilized apartment building sought to overturn DHCR's determination that the building was exempt from rent stabilization due to substantial rehabilitation. The court denied the tenants' petition, finding that DHCR's determination was supported by the evidence and was not arbitrary or capricious. The court also found that DHCR was not required to conduct an in-person inspection of the premises before making its determination.

Variability And Error In Measurement Of Infant Formula Powder And Water: An Experimental Study, Richard R. Rosenkranz, Ana Gonzalez-Alvarez, Chris Acosta, Andrew Hooyman, Jose R. Hidalgo, Cindyromina Ballasteros-Paniagua, Sara K. Rosenkranz

Physical Therapy Faculty Articles and Research

Introduction: Formula feeding is the only viable nutrition alternative for infants 0–6mos who cannot breastfeed. Among the drawbacks of formula feeding, however, is potential dilution or concentration errors in the formula during preparation that may lead to infant health issues. The present study aimed to investigate the accuracy of caregiver measurements as they prepared infant formula under multiple conditions, compared with manufacturer specifications.

Methods: A diverse sample of caregivers (N = 84) participated in this cross-over experimental study. Participants hand-scooped infant formula powder and poured water to prepare 4oz. and 7oz. feedings, using both a standardized set of …

College Athlete Unionization, Roberto Corrada

Texas A&M Law Review

The U.S. Supreme Court’s landmark 2021 decision in NCAA v. Alston has opened the door to serious consideration of the potential for college athlete unionization and collective bargaining. The ruling, highlighted by Justice Kavanaugh’s concurring opinion, suggests collective bargaining as a potential solution to the National Collegiate Athletic Association’s (“NCAA’s”) antitrust vulnerabilities. This Article delves into the initial legal and strategic questions surrounding the prospect of unionization, focusing particularly on NCAA Division I football and basketball, due to their significant revenue generation making them prime candidates for unionization efforts.

The National Labor Relations Board (“NLRB” or “Board”) is positioned to …

Waste Management Process And Malaria-Induced Child Mortality In Côte D’Ivoire., Kouame N'Guessan

Walden Dissertations and Doctoral Studies

Malaria-induced child mortality is a Sub-Saharan African phenomenon, and Côte d'Ivoire, in West Africa, has one of the highest rates. This general qualitative study investigates waste management as a potential factor of malaria-induced child mortality to inform policy changes and fill a gap in the body of knowledge. The study is grounded in Skocpol's policy feedback theoretical framework. The research question explored aspects of waste management in Côte d'Ivoire which contribute to the high rate of malaria-induced child mortality. Eighteen participants, equally divided into three groups, were purposely recruited via email and WhatsApp messages for semi-structured interviews using a smartphone …

The Lived Experiences Of Black Male Students With Non-Black Teachers And Staff In New Orleans, Emmanuel Paul

Walden Dissertations and Doctoral Studies

Academicians, administrators, and policymakers in New Orleans have pointed toward a disproportionate academic and life-cycle outcome where Black American males are particularly disadvantaged as compared to White students. An often-cited cause of these disproportionate outcomes for Black male students is inequality and mistreatment in schools. Therefore, this study explored the educational experiences of 10 Black males aged 18 or over from four alternative public schools in New Orleans via individual interviews. The purpose of this hermeneutic phenomenological qualitative investigation was to explore Black male students’ encounters with non-Black teachers and staff in New Orleans and gain their perspective on their …

Essential Resource Barriers And Perceived Implications Among Military Parents Of Autistic Children, Ann Bayron-Freay

Walden Dissertations and Doctoral Studies

Elevated mental health issues and health care accessibility challenges may be exacerbated by the stressors experienced by military parents of autistic children. The purpose of this interpretative phenomenological analysis was to explore how military parents with autistic children experienced and perceived essential resource barriers. Parent perceptions of the obstacles they experienced with essential resource accessibility led to significant difficulties being identified. The stress process model was used to frame the concepts in this research. Data were collected from semistructured interviews with eight active duty or recently retired military parents who had at least one autistic child during their service. Themes …

The Impact Of Viet Nam’S Socialization Policy On Education And Health Equity Among Disadvantaged Children, Trang Quynh Nguyen

Walden Dissertations and Doctoral Studies

The Xa hoi hoa (socialization) policy was officially adopted by the government of Viet Nam in the late 1990s as a coping strategy for its acute funding shortage in public services with the intent of improving social equity. There was hardly any assessment on the policy to learn its impact on social equity as documented in its key document. Using secondary data from UNICEF’s Multiple Indicator Cluster Surveys conducted in Viet Nam and Viet Nam Household Living Standards Surveys, this study examined the policy’s impact on education and health outcomes among disadvantaged children’s cohorts: the rural, the ethnic minorities and …

Cefiderocol Heteroresistance Associated With Mutations In Tonb-Dependent Receptor Genes In Pseudomonas Aeruginosa Of Clinical Origin, Stephanie L Egge, Samie A Rizvi, Shelby R Simar, Manuel Alcalde, Jose R W Martinez, An Q Dinh, Truc T Tran, Samuel A Shelburne, Jose M Munita, Cesar A Arias, Morgan Hakki, William R Miller

Faculty, Staff and Student Publications

The siderophore-cephalosporin cefiderocol (FDC) presents a promising treatment option for carbapenem-resistant (CR) P. aeruginosa (PA). FDC circumvents traditional porin and efflux-mediated resistance by utilizing TonB-dependent receptors (TBDRs) to access the periplasmic space. Emerging FDC resistance has been associated with loss of function mutations within TBDR genes or the regulatory genes controlling TBDR expression. Further, difficulties with antimicrobial susceptibility testing (AST) and unexpected negative clinical treatment outcomes have prompted concerns for heteroresistance, where a single lineage isolate contains resistant subpopulations not detectable by standard AST. This study aimed to evaluate the prevalence of TBDR mutations among clinical isolates of P. aeruginosa …

Experimental And Fe Investigations Of Backfill Cover On Large-Diameter Grp Pipes, Abdulmuttalib I. Said, Yahya Jabbar Hussein, Mohammed Hazim Mohammed, Abbas A. Allawi

Faculty Publications

This paper presents experimental investigations on buried Glass Reinforced Plastic (GRP) pipes with a diameter of 1400 mm. The tested pipes were buried in dense, gravelly sand and subjected to traffic loads to study the effects of backfill cover on pipe deflection. The experimental program included tests on three GRP pipes with backfill covers of 100 cm, 75 cm, and 50 cm. The maximum traffic loads applied to the pipe–soil system corresponded to Iraqi Truck Type 3 (AASHTO Htype). Vertical deflections of the pipes were monitored during the application of these loads. The experimental results showed that, as the backfill …

A Machine Learning Model For Risk Stratification Of Postdiagnosis Diabetic Ketoacidosis Hospitalization In Pediatric Type 1 Diabetes: Retrospective Study

Faculty, Staff and Students Publications

BACKGROUND: Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in pediatric type 1 diabetes (T1D), occurring in approximately 20% of patients, with an economic cost of $5.1 billion/year in the United States. Despite multiple risk factors for postdiagnosis DKA, there is still a need for explainable, clinic-ready models that accurately predict DKA hospitalization in established patients with pediatric T1D.

OBJECTIVE: We aimed to develop an interpretable machine learning model to predict the risk of postdiagnosis DKA hospitalization in children with T1D using routinely collected time-series of electronic health record (EHR) data.

METHODS: We conducted a retrospective case-control …

Grounded In Liquidity: Writing And Identity In Third Space, Alicja Syska, Carina Buckley, L Heggie

School of Law, Humanities and Social Sciences

This paper argues that writing for publication has the potential to support the creation, negotiation, and stabilising of the professional identities of third space (Whitchurch, 2013) practitioners in higher education. Caught in the impermanence and unpredictability of ‘liquid life’ (Bauman, 2005), third space opens up unique opportunities in writing that afford its practitioners a means of building and sustaining identity. Third space expands academic writing beyond its normative constraints, creating a tension between the apparent permanence and solidity of writing and the liquidity that allows for the negotiation of meaning andidentity. As such, writing, particularly for dissemination, provides third space …

Introduction To The Traffic Coordination System For Space (Tracss), Christine Joseph

Small Satellite Conference

This paper presents an overview of the Department of Commerce’s Traffic Coordination System for Space (TraCSS), its planned architecture, and the basic space situational awareness (SSA) and space traffic coordination (STC) services which it will provide.

In 2018, the White House’s Space Policy Directive-3 identified the Department of Commerce (DOC) as the lead agency for civil SSA, directing transfer of that responsibility from the Department of Defense (DoD), which has historically offered that function to all space operators. This will allow the DoD to focus on its critical space domain awareness needs and mission, while DOC can drive spaceflight safety, …

Design And Testing Of A Resilient Cots Point Of Load Converter For Deep Space Cubesats, Jacob Cook, Phil Bland, Robert Howie

Small Satellite Conference

To support the development of the upcoming Binar Space Program 12U Explorer Class platform, currently being designed for lunar and interplanetary research applications, the design and testing of a modular Gallium Nitride (GaN) based Point of Load (PoL) converter is being undertaken. The converter has been designed to supply power to high-transient-current loads, such as communications systems, by regulating down a higher voltage derived from a range of common CubeSat battery configurations to a target voltage of 5V. The system consists of parallel-connected linear regulator and buck converter stages which deliver power to the load through a high-side current sense …

Maximizing Autonomy On A Small Satellite Platform, Per Bodin, Danilo Costales, Anders Edfors

Small Satellite Conference

OHB Sweden's future generation InnoSat microsatellite platforms will see a large upgrade in the platform's functionality maximizing onboard autonomy. In this paper, three development lines will be presented each contributing to maximizing efficiency and autonomy on a small satellite platform.

The InnoSat platform is a flexible platform concept with a recurring catalog of units, recurrent onboard software and mission control software, and heritage AIT processes. Two InnoSat missions are currently flying: Swedish National Space Agency's MATS and the commercial bring-into-use satellite GMS-T. Two more InnoSat derived missions will be launched in 2024: ESA's Arctic Weather Satellite and Satlantis' Garai-A. In …

Living Dead Forests: Assessing Detrital Services In Puget Sound Pseudotsuga Menziesii Ecosystems, Forrest Becker

Capstone Collection

Coarse woody debris (CWD), the detrital result of down wood recruitment, contributes to wildlife habitat, nutrient cycling, morphological processes like soil formation, and each forest’s sense of place but if undermanaged can fuel wildfires or obstruct stakeholder use. Despite its ubiquity in Puget Sound Douglas fir (Pseudotsuga menziesii) forests in Washington, USA, few studies quantify the exact ecosystem services which down wood provides. This study seeks to understand how forest managers can estimate the ecosystem services of down wood and how human communities perceive down wood management between community, public, and private Douglas fir (P. menziesii) …

"Like Grasping At Wisps Of Smoke:" Interactional And Educational Challenges For College Students With Invisible Chronic Physical And Mental Conditions, Jennifer A. Butler, Daniel P. Modaff

Communication and Theater Association of Minnesota Journal

Past research has explored the experiences of college students with chronic conditions from a variety of methodologies; however, student-driven, longer-term qualitative data is needed to explore how students with chronic conditions describe the challenges they face in attempting to manage their conditions and succeed in college. The current study gathered qualitative data in the form of daily journal entries over a 14-day period (pre-pandemic) from 23 college students who self-identified as having a chronic physical or mental condition. The themes were discussed through the lens of communication theory of resilience. We envision the management of student chronic illness as resiliency …

Volume 47, 2024 Communication And Theater Association Of Minnesota Journal

Communication and Theater Association of Minnesota Journal

Complete digitized volume (volume 47) of Communication and Theater Association of Minnesota Journal.

Deep Purple Payload Qualifies For Nasa Launch, Could Provide New Method For Real-Time Space-Domain Awareness, Jordan Smilo, Frank Ravizza, John Ganino, Jordan Karburn, Lance Simms, Darrell Carter, Princess Corral, Michael Wong, Aaron Godfrey, Brian Bauman, Cohl Houldin Hatala, Ryan Fellini, Lisle Hagler, Wim De Vries, Alex Pertica, Ben Bahney

Small Satellite Conference

In January 2024, the Lawrence Livermore National Laboratory (LLNL) Space Program fully assembled and qualified its Deep Purple payload. It will be on board NASA's Pathfinder Technology Demonstrator-R (PTD-R), scheduled to launch on the SpaceX Transporter 11 in July 2024.

The Livermore team designed, developed, qualified, and delivered the Deep Purple payload in approximately one year and has now been integrated into the PTD-R satellite, a 6U (36 cm x 23 cm x 10 cm) bus constructed by a Laboratory Collaborative Research and Development Agreement (CRADA) partner Terran Orbital.

NASA's Small Spacecraft Technology Programs' PTD-R space vehicle containing the Deep …

Leveraging Cross-Industry Knowledge To Improve The Design Of Space Systems, Jay Lewis, Christian M. Fuchs

Small Satellite Conference

There are valuable satellites that fail early and almost none have been repaired or investigated. Other industries benefit from feedback loops that use failure analysis to accelerate design and manufacturing improvements.¹⁷ Historically the cost of a repair mission would be so high it wouldn't be considered. The cost of space debris mitigation missions can be reduced by leveraging the learning other industries have experienced. Lowering the cost of repair missions will enable more debris mitigation, learn more about why missions failed, and lead to fewer failures and lower costs.

Many space programs rely on outdated processes that increase costs, …

Ua94/6 Pershing Rifles Company B, 3rd Regiment Reunion Album, Stewart Wade

Student/Alumni Personal Papers

Reunion album created by Stewart Wade for the 2024 Pershing Rifles & Rebelettes reunion.

Great Games Need Great Leaders: From Masters To Publication, Matthew Dyet

Staff Scholarship - Australia & Dubai

This talk was given to the SAE Graduate Seminar and looked at the whole process of writing the book Great Games Need Great Leaders. It covers the Masters research that informed the book, the process of interviewing experts from the games industry and other fields, and the writing of the book itself.

Immunological Feedback Loops Generate Parasite Persistence Thresholds That Explain Variation In Infection Duration, Clayton E. Cressler, Daniel C.G. Metz, David A. Chang Van Oordt, Andrea L. Graham

School of Biological Sciences: Faculty Publications

Infection duration affects individual host fitness and between-host transmission. Whether an infection is cleared or becomes chronic depends on the complex interaction between host immune responses and parasite growth. Empirical and theoretical studies have suggested that there are critical thresholds of parasite dose that can determine clearance versus chronicity, driven by the ability of the parasite to manipulate host immunity. However, the mammalian immune response is characterized by strong positive and negative feedback loops that could generate duration thresholds even in the absence of direct immunomodulation. Here, we derive and analyse a simple model for the interaction between T-cell subpopulations …

Constraints On Solar Axions Using The Profile Likelihood Ratio Method With The Supercdms Experiments, Shilun Liu

Physics Theses and Dissertations

Dark matter plays an essential role in understanding modern physics and particles beyond the Standard Model. Evidence suggests that dark matter accounts for approximately 85% of the universe’s matter, and 26.8% of its mass-energy composition. Key candidates for dark matter include unidentified subatomic particles like Weakly Interacting Massive Particles (WIMPs) and axions. The Super Cryogenic Dark Matter Search (SuperCDMS) employs direct detection methods to identify these elusive particles using cryogenic technologies. Su- perCDMS Soudan is the latest completed CDMS experiment in Minnesota, in preparation for the next phase experiments of SuperCDMS SNOLAB in Sudbury, Canada. At SNOLAB, the Cryogenic Underground …

Usa V. Jonathan Goerig

2024 Decisions

USDC for the Eastern District of Pennsylvania

Jane Doe V. Centerville Clinics Inc

2024 Decisions

USDC for the Western District of Pennsylvania

Stephen Krahling V. Merck & Co Inc

2024 Decisions

USDC for the Eastern District of Pennsylvania