Digital Commons Network^™

Usa V. Dion Williams

2024 Decisions

USDC for the Western District of Pennsylvania

Investigating The Impact Of Intervention Design Specialists In Bedford County Public Schools: A Collective Case Study, Brian W. Wilson

Graduate Dissertations and Theses

Educators are focused on helping students achieve academic success. One method that has gained popularity in recent years is multi-tiered systems of support. Tiering systems of support is not a new concept in the field of education. Tiering systems of support rely on the basic concepts of a Response to Intervention (RTI) model for academic and behavioral support. In an RTI model, the level of intervention is increased based on the effectiveness of the intervention on an individual student’s progress toward an established goal. Tiered systems of support create a structured RTI model with leveled systems of support that can …

Investigation Of Using Natural Deep Eutectic Solvents (Nades) For Extraction Of Bioactive Compounds From Aronia Melanocarpa Fruit, Melek Zor

Turkish Journal of Agriculture and Forestry

In this study, for the extraction of polyphenolic compounds found in high amounts in aronia fruit, three different extraction methods (classical, ultrasound, ultrasonic), three different traditional solvents (water, ethanol, acidified 80% methanol) as well as five different natural deep eutectic solvents (NADES) were used. Color indices as L*, a*, b*, C* and H° values, total phenolic, total flavonoid, total monomeric anthocyanin, total antioxidant capacity (DPPH, ABTS and FRAP assays) and phenolic compounds of aronia fruit extracts were analyzed. There were significant differences in the measured parameters depending on the extraction method and solvent type. Extracts in ultrasound extraction and classical …

Recognising Ecological Reflexivity: An Alternative Approach To Partnership Capabilities For Collaborative Governance, Joanna Stanberry, David F. Murphy, Janis Bragan Balda

International Business and Entrepreneurship Faculty Publications

Ecological reflexivity provides a key lever for the implementation of the Sustainable Development Goals (SDGs) but is underexplored in one prominent context: collaborative governance particularly associated with SDG 17. Using an exploratory study and novel approach to Q methodology, we investigate capabilities needed for advancing collaborative governance and cross-sector partnering through an exploratory study. Rather than treating these capacities as universal standards or aims for collaboration between varied stakeholders, they were offered as options that actors may value and choose to advance (or not). Local sustainability-focused actors in North West England sorted capabilities as statements, which discursively reframe multi-stakeholder partnership …

Abiding Presence, Abundant Provision: Water Imagery Within The Temple Motif, Mindy N. Ziegler

Masters Theses

This thesis highlights the richness of the New Testament Christological truths in the Fourth Gospel by tracing the connections John made to the Old Testament history and traditions. John wrote his Gospel account after nearly a lifetime of reflection on the Christ-event and its significance. What had been misunderstood while Jesus walked among his disciples had been illuminated by the Spirit through many years of reflection and study. The New Testament, including the Fourth Gospel, was not written in a vacuum, but drew on a rich and colorful history of Yahweh’s revelation to his people that spanned millennia. The Evangelist’s …

Teaching Reading Comprehension To English Language Learners In A System With A Low Proportion Of Language Minority Students, Chutikarn Cotham

Educational Specialist, 2020-current

This study investigated reading instruction for English language learners (ELLs) by examining teachers' experiences and perspectives on teaching ELL students reading comprehension in an educational system with a low proportion of language minority students. The study addressed the prevalent concern of reading comprehension difficulties among ELLs and the need to bridge the gap between research-based strategies and practices in public schools. Semi-structured interviews were conducted with four educators actively engaged in teaching ELLs at the upper elementary through high school levels. Thematic analysis of the data revealed several themes that were sorted into four main categories: training, curriculum, experience, and …

Michael Williams, Jr. V. Edward Spagel

2024 Decisions

USDC for the Western District of Pennsylvania

Aaron Bressi V. Northumberland County Court

2024 Decisions

USDC for the Middle District of Pennsylvania

Franklin Ramirez-Perez V. Attorney General United States Of America

2024 Decisions

Agency

Amy Spahr V. Amy Collins

2024 Decisions

USDC for the District of Delaware

Ifeoma Ezekwo V. Adam Jacobs

2024 Decisions

USDC for the District of New Jersey

Barry Portnoy V. Commissioner Of Internal Revenue

2024 Decisions

Tax Court

Wandrea Russo V. Bryn Mawr Trust Co

2024 Decisions

USDC for the Eastern District of Pennsylvania

Dying Right: Supporting Anti-Cancer Therapy Through Immunogenic Cell Death, Elizabeth Schmitz

Theses & Dissertations

The primary goal of most anti-cancer therapy is to eradicate neoplastic cells. Simultaneously, neoplastic cell death is the first step of the cancer-immunity cycle, which starts with the release of antigens from cancer cells and ends with T-cell directed killing of cancer cells, in addition to long-standing memory to tumor antigens encountered. Immunogenic damage-associated-molecular patterns (DAMPs) are endogenous cell molecules repurposed in times of insurmountable cell stress (e.g., CALR, ATP, HMGB1) to facilitate communication between dying cells and adaptive immune cells, acting as adjuvants for the cancer-immunity cycle, in a cellular fate termed immunogenic cell death (ICD). It …

Telehealth For Healthy Aging: A Multi-Level, Multi-Methods Approach, Vaibhavi Mone

Theses & Dissertations

Telehealth, rapidly adopted during the pandemic, has shown its usefulness and limitations, yet was not designed with older adults in mind. This dissertation encompasses three interconnected studies exploring telehealth utilization for Medicare Annual Wellness Visits (AWVs) among older adults, provider perspectives on telehealth AWVs, and the impact of teleconferencing on primary care providers' knowledge and confidence in geriatric care. The objectives are to determine patient characteristics using telehealth AWV (study 1), understand provider perspectives on telehealth AWV (study 2), and evaluate the effectiveness of geriatrics education through telehealth (study 3). Study 1 investigates the changes in AWV utilization among 18,405 …

Delivery Of Small Molecule Using Polymeric Nanoparticles For The Treatment Of Alcoholic Liver Disease And Its Pharmacokinetics And Biodistribution In Mice, Jingyi Ma

Theses & Dissertations

Alcoholic liver disease is a challenging chronic disease worldwide. Alcohol abuse and subsequent inflammation, oxidative stress, and disordered lipid metabolism result in liver damage. This dissertation aims to develop a reliable therapeutic strategy for alcoholic liver disease treatment. We have employed polymeric nanoparticles as the delivery system to the liver and utilized PDE4B inhibitor as a novel approach for alcoholic liver disease treatment.

Chapter 1 is an overview of alcoholic liver disease, including the background, pathology, risk factors, and current treatment. In addition, the application of PDE4 inhibitors in alcoholic liver disease was discussed, suggesting a promising avenue for future …

Role Of Pycr2 In Colorectal Cancer, Raju Lama Tamang

Theses & Dissertations

Despite significant progress in clinical management, colorectal cancer (CRC) remains the 3rd most common cause of cancer-related deaths. A positive association of PYCR2 (Pyrroline-5-carboxylate reductase-2), a terminal enzyme of proline metabolism, with CRC aggressiveness was recently reported including by us. However, how PYCR2 promotes colon carcinogenesis remains ill understood. In our studies, comprehensive in-silico and biochemical evaluations were performed along with genetic manipulations and in-vivo tumor growth assays to gain mechanistic understanding. Results showed that PYCR2 expression was significantly upregulated in CRC and associated with poor patient survival specifically among PYCR isoforms (PYCR-1, -2 and -3). Genetic inhibition of PYCR2 …

The Dormition And The Assumption: Whatever Happened To Mary?, Michele Jennings

Marian Library Blog Archive

With the Solemnity of the Assumption of the Blessed Virgin Mary approaching, we explore the Dormition of the Theotokos, a related feast day in Orthodox traditions.

Central Nervous System Antiviral Pharmacology, Sean N. Avedissian

Theses & Dissertations

Soon after viral infection, viruses like Human Immunodeficiency Virus (HIV) and SARS-CoV-2 can disseminate throughout the body and establish reservoirs in the central nervous system (CNS). The persistence of viruses in cells of these reservoirs is a major obstacle to virus eradication. This is due to the abundance of cells/receptors that these viruses utilize to gain entry into cells found at these various reservoir sites. Consequently, these same anatomical sites also may be pharmacologic sanctuaries, as evidenced by concentrations of antiretroviral drugs (ARVs) and antivirals (AVs) that are lower in reservoirs than those in peripheral blood; in some cases, these …

Legal Regime Of The Application Process For Gmo Products In Türkiye, Ünal Yildiz, Özgür Temi̇z, Kami̇l Hali̇loğlu, Nesri̇n Yildiz

Turkish Journal of Agriculture and Forestry

In Turkiye, in accordance with EU harmonization laws, Biosafety Act No. 5977 entered into force on 18.09.2010. The basic legislation regarding the application process is composed of the Biosafety Act, Regulations on Genetically Modified Organisms and Their Products, and Regulations on Working Procedures and Principles of Biosafety Board and Committees. Biosafety legislation foresees a special application procedure for GMO food, food products, feed, and other products. The application regulated in the Biosafety Law is a special administrative procedure in nature. The primary objective of this study is to explain the legal regime of this application procedure. While explaining this issue, …

Evaluation Of Turkish Shallot Genetic Resources For Morphological, Biochemical And Sensory Properties, Gülay Beşi̇rli̇

Turkish Journal of Agriculture and Forestry

Shallots, a subspecies of onion, are considered the gourmet onion and are preferred especially in French and Asian cooking. Its unique taste and aroma especially being caramelized through heat treatment increases its importance for boutique restaurants and niche tables. This study examined the morphological, biochemical, and sensory properties of seven generatively (GMSY-2, GMSY-3, GMSY-4, GMSY-5, GMSY-6, GMSY-7, GMSY-8) and one vegetatively propagated (GMSY-1) shallot genotypes in 2021 and 2022. Sixteen morphological and fifteen biometric features of UPOV were used in characterization. Total phenolic content, total antioxidant capacity, and total monomeric anthocyanin and pyruvic acid contents were determined as biochemical markers. …

Cognitive Reappraisal: The Bridge Between Cognitive Load And Emotion, Rebecca Brockbank, David F. Feldon

Instructional Technology and Learning Sciences Faculty Publications

Within this integrative review, cognitive load theory (CLT) is asserted as a powerful framework for conceptualizing human cognitive processes within learning. The relationship between cognition and emotion is then examined and further integrated within the scope of CLT. Emotion regulation strategies are discussed and adaptive strategies are proposed as being of particular relevance to broadening the theoretical and practical impacts of CLT. Central to the argument of this review is the use of cognitive reappraisal as a potential mitigator of cognitive load. Cognitive reappraisal involves reframing or reassessing understandings or beliefs that underlie an emotional response, which may mitigate cognitive …

Inequities Beyond Surplus Equity: Fixing The Limited Remedies Of Tyler, Julie Gilgoff

San Diego Law Review

When the Supreme Court declared “home equity theft” policies a Fifth Amendment taking in Tyler v. Hennepin County, a diverse coalition celebrated its holding. To the unsuspecting, the Tyler decision appears to be motivated by fairness in returning surplus equity to an elderly African-American tax-delinquent homeowner. But when low-income homeowners lose their greatest asset due to even minimal tax debt, returning a fraction of the value (the surplus) is hardly an adequate remedy. This Article refocuses attention away from the invalidation of “home equity theft” policies to larger inequities in the U.S. property tax system that have a disparate …

Cutting Zoning Down To Size: Reevaluating The Legal Vulnerability Of Urban Minimum Lot Sizes, Charles Gardner

San Diego Law Review

Minimum lot sizes are among the most common forms of land use regulation in the United States, existing even in those jurisdictions that have not adopted traditional use-based zoning. Although scholarly and judicial attention has focused on the minimums of an acre or more that are typically found in suburban areas, recent research has identified substantial economic benefits to reforming and reducing the lower minimums present in city neighborhoods. This Article argues that these minimums, often requiring 5,000 square feet or more per home in areas served by city sewer and water, may be vulnerable to litigation on the basis …

Narrowing “The Gap”: Counter Gray Zone Operations, Raul (Pete) Pedrozo

International Law Studies

China is exploiting "The Gap" by conducting provocative Gray Zone operations to challenge its neighbors' sovereignty and sovereign rights, as well as their navigational rights and freedoms, in waters off their coast in the East China Sea, Taiwan Strait, and South China Sea. By engaging in malign activities that fall below the threshold of an "armed attack," China anticipates it can incrementally advance its interests without eliciting a military response from the targeted States. Diplomatic protests and third-party dispute settlement have not convinced China to halt its aggressive behavior. This article suggests States should use non-lethal counter-piracy tactics, techniques, and …

Remote Work And The Desire For Meaningful Work: The Unexpected Moderating Effects Of Age And Childrearing, Adriana Rae Meredith

Master's Theses

The COVID-19 pandemic sent the world into lock down. Since then, organizations have been wrestling with how to navigate the many opinions, as well as research-backed advantages and disadvantages of in-office work, hybrid work, and remote work. In addition to shaking up the ways in which work is done, the pandemic shutdowns caused some to re-evaluate why they do the work they do. The current study aimed to examine the relationship between remote work and an employee’s desire for meaningful work to increase understanding of how remote work can be used as a strategic element of job design rather than …

Deep-Learning Approaches To Predict Remaining Useful Life Of Hard Disks, Rohan Mohapatra

Master's Theses

On a daily basis, data centers process huge volumes of data using inexpensive hard disks. Data stored in these disks serve a range of critical functional needs from financial, and healthcare to aerospace. As such, premature disk failure and consequent loss of data can be catastrophic. To mitigate the risk of failures, cloud storage providers perform condition-based monitoring and replace hard disks before they fail. By estimating the remaining useful life (RUL) of hard disk drives, one can predict the time-to-failure of a particular device and replace it at the right time, ensuring maximum utilization whilst reducing operational costs. We …

“It Makes Me Wonder, How I Keep From Goin’ Under:” Deconstructing Cultural Strengths In The Stories Of Black College And University Students, Sikeza C. Fowlks

Master's Theses

To deconstruct conceptualizations of Black cultural resiliency outside of the perception of the current dominant culture, the present study interviewed Black university and college students for their narratives about their perceptions of Black culture and how they navigate systemic oppression. To create a full conceptualization of Black issues and cultural resilience this study explored the current literature around Black experiences of racism and its relationship to Race-Based Trauma. Additionally, the researcher expanded upon current interventions used to mitigate Race-Based Trauma and how Black culture is currently defined within systemic oppression. To answer the study’s research question framework around Black cultural …

Sterling Apt Llc V. Norvell

All Decisions

In this nonpayment proceeding, the tenant moved to dismiss, arguing there was no valid lease in effect. The court granted the motion. Despite the landlord's argument that acceptance of ERAP payments created an implied lease, the court held that this did not apply to rent-stabilized tenancies. The court distinguished cases involving unregulated tenancies and emphasized that the appropriate course of action for the landlord was to pursue a holdover proceeding for failure to renew the lease.

Design And Implementation Of A Modular, Standalone Microfluidic Flow Control Platform For Cell Culture Applications, Meng-Chun Hsu

Theses

Microfluidics, a technology of manipulating small quantities of fluids (0.1-10 µL), has drawn interest as an emerging platform for biomedical and chemical applications since its debut due to several advantages, including better precision in flow rate control, smaller required sample sizes, lower costs of analyses, and shorter turnaround times. Well-defined fluid flows are the hallmark feature of microfluidic culture systems and enable precise control over biophysical and biochemical cues at the cellular scale. One key demand for microfluidics is to control the delivered fluid flows to downstream applications. This is generally achieved via two major components – valves and pumps. …