Digital Commons Network^™

Investigating The Oncogenic Role Of Nkx3.1 In Prostate Cancer, Audris Budreika

Master's Theses

Prostate cancer is a unique disease in that it is fueled by androgen receptor (AR) signaling. In the clinic, AR signaling is disrupted by removing androgens via chemical castration and employing AR-antagonists such as enzalutamide. Unfortunately, these therapies are short-lived, resistance sets in, and tumors evolve to a form of the disease called castration-resistant prostate cancer (CRPC). At this stage, therapeutic options are virtually exhausted and palliative care is pursued. There is a growing need to characterize other molecular players that cooperate with AR or play a unique role in CRPC on their own. One such potential candidate is the …

Characterization Of Cd11c-Expressing Gut-Associated T Cells, Ana Cvetkovic

Master's Theses

Our immune system is a remarkable defense network that protects our bodies from a range of threats. Its’ intricate machinery comprises of messenger and effector cells that work together to coordinate an effective immune response. Traditionally, T lymphocytes have been considered effectors: they receive instructions from messengers, known as Antigen Presenting Cells (APCs), that alter T-cell activation state and behavior. In the gut, Dendritic Cells (DCs) are the APCs that most often instruct T cells. To accomplish their messenger role, DCs express CD11c at high levels, a surface marker involved in cell-to-cell signaling and phagocytosis. As such, CD11c expression has …

The Effects Of Conditional Loss Of Myosin Binding Protein H-Like On Cardiac Function, Hope Victoria Burnham

Master's Theses

Dilated cardiomyopathy (DCM) is a common cause of heart failure with a strong hereditary component. Mutations in the myosin-binding protein H-like (MYBPHL) gene are linked to hereditary DCM, atrial fibrillation, and atrioventricular arrhythmias. MyBP-HL is a sarcomeric protein that is highly expressed in the atria with only scarce, distinct clusters of MyBP-HL positive cells in the ventricles, mostly in or surrounding the ventricular conduction system (VCS). Constitutive knock-out of MyBP-HL in mice causes atrial dilation, ventricular dysfunction, arrhythmia, and DCM. Whether MyBP-HL plays a developmental role, or if knock-down in adulthood will recapitulate a similar phenotype has yet to be …

Relationship Between Anti-Seizure Medication And Behaviors That Challenge In Older Persons With Intellectual Disability And Epilepsy: A Review, Rohit Shankar

Peninsula Medical School

Introduction: There is increased focus on the negative impact of the overprescribing of medication, specifically psychotropic medication, including anti-seizure medications (ASM), in people with Intellectual Disability (ID). This is particularly important for the older adult population, where multi-morbidity and polypharmacy are more common. ASMs are associated with psychiatric and behavioral adverse effects. Furthermore, there is growing awareness of the anticholinergic burden for older adults with epilepsy and ID and the relationship with behaviors that challenge (BtC). Areas covered: This review defines the older adult population and outlines the relationship between epilepsy and ID. BtC is outlined in the context of …

Dissenting Opinion?, Richard Collins

Tribal Law Journal

Johnson v. M’Intosh is important for its extensive description of the racist Doctrine of Discovery. But its holding had no bearing on legal rights of American Indian nations. The opinion’s articulation of tribal rights to land ownership and retained sovereignty were correctly stated.

The International Law Of Colonialism: Johnson V. M’Intosh And The Doctrine Of Discovery Applied Worldwide, Robert J. Miller

Tribal Law Journal

The United States Supreme Court’s first Indian law case, Johnson v. M’Intosh, was decided in 1823. In that case, the Court summarized and then applied four hundred years of international law and colonization to the Indigenous nations and peoples within the United States. Johnson is still the law in the United States today and has also influenced the jurisprudence and histories of other settler colonial countries around the world. Johnson has been cited scores of times by courts in New Zealand, Australia, and Canada, as well as by the British Privy Council. The elements or factors that make up this …

Bizindan Miinawa (Listen Again), Matthew L.M. Fletcher

Tribal Law Journal

Johnson v. McIntosh was as fake as John Wayne’s teeth. That one was a property dispute, remember? Two wealthy, privileged, and powerful white people squared off over thousands of acres of land acquired from Indigenous nations who called the vast valley of Eagle River home. On one side, you had a former United States Supreme Court Justice; on the other, you had a wealthy political benefactor/beneficiary. No tribal nations or Indigenous peoples to be seen or heard from. And of course, the competing property claims at issue barely overlapped, if at all, thanks to stipulations of the parties at the …

Environmental Justice Is A Civil Rights Issue, Secretary Deb Haaland

Tribal Law Journal

No abstract provided.

Amber Klein Petitoner/ Appellee V. Melvin James Klein Respondent/ Appellant : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from ruling of the Honorable Judge Marvin D. Bagley of the Sixth District in and for Sanpete County as to a Decree of Divorce.

Brody N. Miles, Attorney for Melvin James Klein Appellant

Douglas Neeley, Attorney for Amber Klein Appellee

Bella & Sons Realty Llc V. Polanco

All Decisions

The landlord's non-payment proceeding was dismissed due to significant defects in the rent demand. The tenant successfully argued that the rent demand was defective because it did not align with the landlord's rent ledger and included amounts already paid. The court found these defects rendered the demand invalid, leading to dismissal of the case.

The Role Of Middle Management In Influencing Corporate Culture Change Success, Robert Aaron Parsons

Walden Dissertations and Doctoral Studies

Failure of organizations’ strategic change initiatives typically leads to continued mitigated financial performance. Grounded in transformational leadership theory, the purpose of this qualitative multiple case study was to identify and explore strategies and processes middle managers use to support and implement organizational culture change initiatives to increase organizational financial performance. The participants were four middle managers from two transportation companies in Ohio that experienced thriving organizational culture changes to increase organizational financial performance. Data were collected using semistructured interviews and reviewing public financial statements. Data were analyzed using thematic analysis, and three principal themes emerged: participating in organizational culture change …

Elucidating Enterococcal Mechanisms Underlying Recurrent Urinary Tract Infections, Baylie Hochstedler-Kramer

Dissertations

Urinary tract infection (UTI) is one of the most common bacterial infections globally and can lead to life-threatening complications. UTI disproportionately affects females, with the majority of females being treated for at least one UTI in their lifetime. Of the females who develop UTI in their lifetime, almost one third will develop recurrence within six months after initial treatment and many will struggle with UTI recurrence for long spans of their lives. Although recurrent UTI has previously been attributed to persistence of Escherichia coli, recent studies utilizing more sensitive detection methods have shown Enterococcus faecalis is strongly associated with recurrent …

Absolute Quantification Of Human Myosin And Titin Isoforms In Disease By A Mass Spectrometry Approach, Nitha Aima Muntu

Master's Theses

Heart failure (HF) is the leading cause of death worldwide and produces an immense economic burden. Dilated cardiomyopathy (DCM), characterized by contractile weakness and chamber dilation, is a significant cause of HF. The sarcomeric proteins play a crucial role in regulating the contractile properties of the heart. As the primary motor protein, the expression of cardiac myosin isoforms (α-MHC and β-MHC) dictates the performance and cardiac energy utilization of the sarcomere. Titin is the giant spring protein in the sarcomere, and titin isoform expression impacts the passive stiffness of the myocardium. Small changes in the α-MHC/β-MHC and titin isoform ratios …

A Comprehensive Review And Meta-Analysis Of Breast Cancer Gene Expression Data: Understanding The Molecular Complexity Of A Silent Epidemic, Ifeanyichukwu O. Nwosu

Theses and Dissertations

Breast cancer is the most frequently diagnosed cancer type and the leading cause of cancer death; it accounts for 23% of total cases and 14% of deaths, with over 2 million new cases diagnosed and 600,000 deaths in 2020. This is a huge public health burden. Traditionally, clinical subtypes of breast cancer are defined based on a patient's immunohistochemistry profile. These profiles are determined by the combined expression status of three receptors: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. It has also been observed that women of African descent, more commonly present with ER, PR and …

Students As Value Co-Creators In The Business Education Ecosystem, Maria Petrescu, John Gironda, Anjala S. Krishen, Adina Dudau, J. Ricky Fergurson, Steven A. Stewart, Philip Kitchen, Monica Fine

Publications

Departing from the dyadic paradigm of students versus business schools in marketing and business education, this article utilizes a pluralistic perspective to account for and investigate various stakeholder groups’ value expectations and roles as we develop and examine a value co-creation ecosystem framework for marketing and business education. Service-Dominant Logic and Authority Theory are used as theoretical lenses along with a mixed-method approach to conduct three studies: (a) a fuzzy-set qualitative comparative analysis (fsQCA), (b) a qualitative conceptual mapping content analysis, and (c) a three-round quantitative Delphi study. The results provide insights into the differing elements of value and level …

Bridging The Global Divide In Ai Regulation: A Proposal For A Contextual, Coherent, And Commensurable Framework, Sangchul Park

Washington International Law Journal

As debates on potential societal harm from artificial intelligence (AI) culminate in legislation and international norms, a global divide is emerging in both AI regulatory frameworks and international governance structures. In terms of local regulatory frameworks, the European Union (E.U.), Canada, and Brazil follow a “horizontal” or “lateral” approach that postulates the homogeneity of AI, seeks to identify common causes of harm, and demands uniform human interventions. In contrast, the United States (U.S.), the United Kingdom (U.K.), Israel, and Switzerland (and potentially China) have pursued a “context-specific” or “modular” approach, tailoring regulations to the specific use cases of AI systems. …

Nakomidizo: An Anishinaabe Law Response To Two-Hundred Years Of Johnson V. M'Intosh And The Doctrines Of Discovery And Implicit Divesture, Kekek Jason Stark

Faculty Law Review Articles

Responding to the history involved in the establishment and perpetuation of the doctrines of discovery and implicit divesture, this article critiques how federal Indian law has been developed to support the diminishment of tribal sovereignty through the perpetuation of historical assimilation policies. In response, this article will show that the diminishment of tribal sovereignty through the perpetuation of historical assimilation policies can be overcome with the effective implementation of tribal law principles. To counter the narrative of diminished sovereignty, I offer an understanding of the trust responsibility from an Anishinaabe law perspective. In particular, the revitalization of tribal law through …

Role Of Vegfa In Intervertebral Disc Pathoanatomy And Low Back Pain, Ryan Potter

McKelvey School of Engineering Graduate Student Theses & Dissertations

Chronic low back pain (LBP) affects more than 80% of Americans and causes significant disability and staggering public health costs. Despite this astonishing prevalence, there are currently no disease modifying therapies. Intervertebral disc (IVD) degeneration accounts for a considerable proportion of LBP, but the precise mechanisms driving the painful pathoanatomy are not understood. The degenerating IVD exhibits a complex array of inflammatory and physiologic changes, and many are associated with the presentation of LBP. For example, the presence of nerves and blood vessels in degenerate IVDs have been identified in patients and animals presenting with LBP symptoms. However, no studies …

Judicial Perspectives On Sentencing Mentally Ill Violent Offenders In New York, Vinita Puri

Walden Dissertations and Doctoral Studies

Mass incarceration is a public health crisis in the United States. Scholarly research has shown that incarceration may lead to exacerbated psychiatric conditions and increased recidivism risk. Lawmakers and policymakers have turned toward therapeutic jurisprudence (TJ) to develop and implement trauma-informed crime prevention and intervention strategies that focus on diverting individuals from prisons and into community-based treatment. New York legislators have expanded problem-solving courts (e.g., mental health courts), psychiatric treatment facilities, public housing supports, and law enforcement training. In this generic qualitative study, five criminal court judges in New York shared their perspectives on TJ and trauma-informed approaches to sentencing …

Exploring Human Capital Development: Perspectives Of Young Adults (Aged 18-25) In Lagos, Nigeria, Omobola Omotimirin

Walden Dissertations and Doctoral Studies

Under-utilization of youth human capital and youth delusion, has the attendant effect of increased crime, insecurity, deplorable infrastructure, loss of foreign investment, revenue loss, etc. The large population of young adults (age 18-25) in Lagos State, Nigeria, is a source of human capital development. There is little to no literature on the young adults’ (age 18-25) perspectives on their human capital development in Lagos State. The purpose of this study was to understand the perspectives of young adults (age 18-25) on their human capital development needs. Research questions focused on understanding young adults’ perception on human capital development; how youth …

Sleep Restores An Optimal Computational Regime In Cortical Networks, Yifan Xu

Arts & Sciences Graduate Student Theses and Dissertations

Computation within the brain necessitates consistency and robustness, as no complex system can function effectively without these fundamental attributes. However, maintaining this robustness requires active efforts due to the inevitable perturbations (Turrigiano & Nelson, 2004). To unlock the unifying principle of how brain works, it is essential to identify an optimal set point that the system strives to maintain and restore, ensuring stability and functionality. Our lab recently demonstrated that cortical dynamics are homeostatically organized around criticality (Ma et al., 2019), a computational regime that optimizes information processing, such as information capacity and dynamic range (Shew & Plenz, 2013). This …

Nakomidizo: An Anishinaabe Law Response To Two-Hundred Years Of Johnson V. M’Intosh And The Doctrines Of Discovery And Implicit Divesture, Kekek Jason Stark

Tribal Law Journal

Responding to the history involved in the establishment and perpetuation of the doctrines of discovery and implicit divesture, this article critiques how federal Indian law has been developed to support the diminishment of tribal sovereignty through the perpetuation of historical assimilation policies. In response, this article will show that the diminishment of tribal sovereignty through the perpetuation of historical assimilation policies can be overcome with the effective implementation of tribal law principles. To counter the narrative of diminished sovereignty, I offer an understanding of the trust responsibility from an Anishinaabe law perspective. In particular, the revitalization of tribal law through …

Exploring Successful Strategies For Small Business Owners’ Access To Financing, Emmanuel Innocent

Walden Dissertations and Doctoral Studies

Considered the drivers of innovations and the engine of the economy, small and medium enterprises (SMEs) represent 99% of U.S. firms. However, nearly 80% of SMEs fail in their 1st year of operation, causing substantial financial hardship to the small business owners and significant loss of tax revenues to local and federal governments. Grounded in the theory of planned behavior, the purpose of this qualitative, pragmatic inquiry was to explore successful strategies that some small business owners use to gain access to financing for their businesses. The participants comprised six small business owners in Norfolk County, Massachusetts, United States, who …

Competition In The Banking Industry: An Empirical Study, Angela Smith Mcgee

Walden Dissertations and Doctoral Studies

According to recent studies, U.S. bank customers have been dissatisfied with banks and bank fees; therefore, some bank CEOs need to understand the relationship between the rise of cryptocurrencies, third-party payment services, and traditional bank startups. Using Porter’s five forces theory, the purpose of this quantitative, ex post facto, study was to determine if the dollar value of U.S. cryptocurrency startups, and U.S. third-party payment service startups predict U.S. bank startups. The sample of twenty-four records consisted of initial public offerings (IPO’s) within each month of the two-year period aggregated by variable dollars publicly listed in the Securities and Exchange …

Advances In Chalcogenide Crystal Growth, Anna Berseneva

Theses and Dissertations

Chalcogenides are the cornerstone of the semiconductor and thermoelectric industries and are up-and-coming materials for superconductors, catalysis, and battery applications. Challenges in the synthesis of those materials emerge from the chalcogen’s volatility and the tendencies of chalcogenide to react with even trace quantities of oxygen. Nonetheless, many techniques have been applied to the growth of chalcogenide single crystals, which are convenient for structure determinations and intrinsic property measurements. This dissertation will detail synthetic strategies applied to the crystal growth of novel chalcogenide materials via molten flux preparation (Chapters 2, 4, and 5), hydrothermal synthesis (Chapter 1 and 3), and single-crystal-to-single …

Thermodynamic Modeling Of Uranium Nitride With Select Actinides And Fission Products, Eric Reece Mcmanus

Theses and Dissertations

Uranium mononitride fuel is being investigated as a potential nuclear fuel for a Westinghouse lead-cooled fast reactor due to factors such as its high uranium density, high melting point, and favorable thermal conductivity. To obtain an understanding of the thermochemical behavior of UN fission products and minor actinides, thermodynamic data was obtained from various resources to create a database to represent the behavior of the fuel. This database was used to generate an Ellingham diagram to represent the relative thermodynamic stability of the phases over the reactor temperature range. A simulation was run computing the equilibrium state of the fuel, …

A Formative Process Evaluation Of Social Care Programming In A Health Care System Serving A Predominantly Rural State, Samuel Bethel

Theses and Dissertations

Health and social care continue to integrate, but relatively little is known about how social care is designed, implemented, and maintained across the health care continuum. This is especially true for health systems serving rural and under-resourced communities. To fill these gaps, this dissertation project applied formative process evaluation methods to a single case study of the largest health care system serving a predominantly rural state and its integrated social care programming. Data were collected from in-depth, semi-structured interviews following a purposeful and snowball sampling method among key informants for the design, implementation, and maintenance of social care programming as …

Erodibility Of Sand-Silt-Xanthan Gum Mixtures, Edwin Kotey

Theses and Dissertations

The high frequency of earthen embankment failure recorded during floods has led to the general rule that embankments should not be overtopped. This notwithstanding, overtopping cannot be entirely avoided particularly during extreme events, such as winter storms and hurricanes. Reducing soil erodibility is thus fundamental to prevent and control disasters caused by embankment failure. Recent studies have explored the use of environmentally friendly additives, such as biopolymers, to improve soil properties. Geotechnical tests have shown that biopolymers can effectively increase soil strength, but little is known about biopolymer-treated soil resistance to erosion by flowing water. Results of flume experiments to …

Ndls Communicator: Week Of 08.19.24, Notre Dame Law School

NDLS Communicator

The Latest News

• Notre Dame Law School launches Intellectual Property Externship led by alumna Jenna Tracy '19 J.D.
• ND Law’s Exoneration Justice Clinic receives generous gift to expand exoneree reentry services

Student News

• Notre Dame Law students gain experience through summer in-house legal work at major corporate firms
• The Supreme Court Historical Society announced that Dennis Wieboldt is the recipient of the 2024 Henry J. Abraham Early Career Research Grant. Wieboldt is a Richard and Peggy Notebaert Premier Fellow at the Graduate School and a Edward J. Murphy Fellow at the Law School.
• The Exoneration Justice Clinic was mentioned in …

Design, Synthesis, And Evaluation Of Oleyl-Wrh Peptides For Sirna Delivery, Mrigank Shekhar Rai, Muhammad Imran Sajid, Jonathan Moreno, Keykavous Parang, Rakesh Kumar Tiwari

Pharmacy Faculty Articles and Research

Delivering nucleic acid therapeutics across cell membranes is a significant challenge. Cell-penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) show promise for siRNA delivery. To improve siRNA delivery and silence a model STAT3 gene, we hypothesized that oleyl acylation to CPPs, specifically (WRH)n, would enhance STAT3 silencing efficiency in breast and ovarian cancer cells. Using Fmoc/tBu solid-phase peptide chemistry, we synthesized, purified, and characterized the oleyl-conjugated (WRH)n (n = 1–4) peptides. The peptide/siRNA complexes were non-cytotoxic at N/P 40 (~20 μM) against MDA-MB-231, MCF-7, SK-OV-3, and HEK-293 cells after 72 h incubation. All peptide/siRNA complexes showed serum …